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https://www.readbyqxmd.com/read/30076591/clinical-value-of-inflammation-based-prognostic-scores-to-predict-the-resectability-of-hyperbilirubinemia-patients-with-potentially-resectable-hilar-cholangiocarcinoma
#1
Hai-Jie Hu, Yan-Wen Jin, Rong-Xing Zhou, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Fei Liu, Nan-Sheng Cheng, Fu-Yu Li
BACKGROUND: We aimed to examine whether inflammation-based prognostic scores could predict tumor resectability in a cohort of hilar cholangiocarcinoma patients with preoperative hyperbilirubinemia. We also sought to investigate the prognostic factors associated with overall survival in the subgroup of patients with an R0 resection. METHODS: A total of 173 patients with potentially resectable hilar cholangiocarcinoma, as judged by radiological examinations, were included...
August 3, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29740014/different-patterns-of-epileptiform-like-activity-are-generated-in-the-sclerotic-hippocampus-from-patients-with-drug-resistant-temporal-lobe-epilepsy
#2
Selvin Z Reyes-Garcia, Carla A Scorza, Noemi S Araújo, Nancy N Ortiz-Villatoro, Anaclara Prada Jardim, Ricardo Centeno, Elza Márcia Targas Yacubian, Jean Faber, Esper A Cavalheiro
Human hippocampal slice preparations from patients with temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) are excellent material for the characterization of epileptiform-like activity. However, it is still unknown if hippocampal regions as cornu Ammonis (CA) 1, CA3 and CA4, generate population epileptiform-like activity. Here, we investigated epileptiform activities of the subiculum, CA1, CA2, CA3, CA4 (induced by elevation of extracellular potassium concentration) and the dentate gyrus (induced with hilar stimulation and elevation of potassium concentration) from sclerotic hippocampi of patients with drug-resistant TLE...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/28932613/primary-pulmonary-lymphoma-presenting-with-superior-vena-cava-syndrome-in-a-young-female
#3
Divya Salhan, Prakash Verma, Tun Win Naing, Ebad Ur Rehman, Saroj Kandel, Danillo Enriquez, Joseph Quist, Frances Schmidt
Primary Pulmonary Diffuse Large B Cell Lymphoma (PPDLBCL) is an extremely rare entity, which exhibits an aggressive behavior by compressing local blood vessels. It represents only 0.04% of all lymphoma cases and is extremely rare in young age. We present a case of a primary pulmonary lymphoma with superior vena cava syndrome (SVCS) in a young female. 27-year-old African American female presented with fever, cough, and facial puffiness for 2 weeks and unintentional weight loss. Chest examination showed decreased breath sounds and dullness on percussion on right side...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/28709070/ethanol-production-in-a-simultaneous-saccharification-and-fermentation-process-with-interconnected-reactors-employing-hydrodynamic-cavitation-pretreated-sugarcane-bagasse-as-raw-material
#4
Ruly Terán Hilares, João Vitor Ienny, Paulo Franco Marcelino, Muhammad Ajaz Ahmed, Felipe A F Antunes, Silvio Silvério da Silva, Júlio César Dos Santos
In this study, sugarcane bagasse (SCB) pretreated with alkali assisted hydrodynamic cavitation (HC) was investigated for simultaneous saccharification and fermentation (SSF) process for bioethanol production in interconnected column reactors using immobilized Scheffersomyces stipitis NRRL-Y7124. Initially, HC was employed for the evaluation of the reagent used in alkaline pretreatment. Alkalis (NaOH, KOH, Na2CO3, Ca(OH)2) and NaOH recycled black liquor (successive batches) were used and their pretreatment effectiveness was assessed considering the solid composition and its enzymatic digestibility...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28606280/-importance-of-segmental-lymph-nodes-in-the-pathological-staging-of-non-small-cell-lung-cancer
#5
J D Huang, X D Li, R Q Wang, H Huang, H C Ouyang, H Yang
Objective: To explore the role of the segmental lymph node dissection in the pathologic staging of non-small cell lung cancer. Methods: A total of 370 consecutive non-small cell lung cancer patients who underwent radical resection between August 2008 and July 2016 were retrospectively reviewed. All the operations were performed by the same group of surgeons. The relationship of the segmental lymph nodes with pathological stages after radical resection was analyzed in order to explore the role of the lymph node dissection in the pathologic staging of non-small cell lung cancer (using the 7th edition of the American Joint Committee on Cancer and Union for International Cancer Control TNM classification for lung cancer )...
June 13, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28290711/visualising-a-rare-and-complex-case-of-advanced-hilar-cholangiocarcinoma
#6
Jia Qu, Albert Fung, Paul Kelly, Gordon Tait, Paul D Greig, Anne Agur, Ian D McGilvray, Jodie Jenkinson
The Toronto Video Atlas of Liver, Pancreas, Biliary, and Transplant Surgery (TVASurg) is a free online library of three-dimensional (3D) animation-enhanced surgical videos, designed to instruct surgical fellows in hepato-pancreato-biliary (HPB) and transplant procedures. The video 'Klatskin tumours: Extended left hepatectomy with complex portal vein reconstruction and in situ cold perfusion of the liver', which is available to watch at http://TVASurg.ca , is a unique and valuable visual resource for surgeons in training to assist them in learning this rare procedure...
January 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/27914884/clinical-presentation-diagnosis-and-survival-in-cholangiocarcinoma-a-prospective-study
#7
Larisa Vasilieva, Stefanos I Papadhimitriou, Alexandra Alexopoulou, Ioannis Kostopoulos, Konstantinos Papiris, Dimitrios Pavlidis, Dimitrios Xinopoulos, Andreas Romanos, Spyridon P Dourakis
BACKGROUND AND STUDY AIMS: The diagnosis of cholangiocarcinoma (CCA) is difficult. The present study aimed to assess the clinical features, diagnosis, and survival in CCA. PATIENTS AND METHODS: This is a prospective study on 46 patients with CCA who underwent endoscopic retrograde cholangiopancreatography (ERCP) or surgical resection and 20 controls with a clinical and ERCP suspicion for CCA in whom surgical biopsy and/or 4-year follow-up showed a benign biliary stricture...
December 2016: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/27888509/functional-properties-of-granule-cells-with-hilar-basal-dendrites-in-the-epileptic-dentate-gyrus
#8
Tony Kelly, Heinz Beck
OBJECTIVE: The maturation of adult-born granule cells and their functional integration into the network is thought to play a key role in the proper functioning of the dentate gyrus. In temporal lobe epilepsy, adult-born granule cells in the dentate gyrus develop abnormally and possess a hilar basal dendrite (HBD). Although morphological studies have shown that these HBDs have synapses, little is known about the functional properties of these HBDs or the intrinsic and network properties of the granule cells that possess these aberrant dendrites...
January 2017: Epilepsia
https://www.readbyqxmd.com/read/27581393/neural-cell-proliferation-and-survival-in-the-hippocampus-of-adult-cav-2-1-calcium-ion-channel-mutant-mice
#9
Fikru Nigussie, Pei-San Huang, Kris Lukauskis, Bhupinder Bawa, Eid Moussa, Louise C Abbott
Tottering mutant mice carry a mutation in the pore-forming subunit (α1A) of CaV 2.1 (P/Q-type) voltage-gated calcium ion (Ca2+ ) channels resulting in reduced neuronal Ca2+ current density. We assessed male tottering mice for spatial learning using the Morris water maze. Tottering mice performed worse than wild type mice, suggesting abnormal hippocampal function. Because Ca2+ influx via voltage-dependent Ca2+ channels regulates neuronal survival and function, we assessed hippocampus volume and cell density using hematoxylin and eosin stained serial sections...
November 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27549595/defining-the-chance-of-statistical-cure-among-patients-with-extrahepatic-biliary-tract-cancer
#10
Gaya Spolverato, Fabio Bagante, Cecilia G Ethun, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley Krasnick, Emily Winslow, Clifford Cho, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: While surgery offers the best curative-intent treatment, many patients with biliary tract malignancies have poor long-term outcomes. We sought to apply a non-mixture cure model to calculate the cure fraction and the time to cure after surgery of patients with peri-hilar cholangiocarcinoma (PHCC) or gallbladder cancer (GBC). METHODS: Using the Extrahepatic Biliary Malignancy Consortium, 576 patients who underwent curative-intent surgery for gallbladder carcinoma or peri-hilar cholangiocarcinoma between 1998 and 2014 at 10 major hepatobiliary institutions were identified and included in the analysis...
January 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/27358676/predictors-of-long-term-survival-after-hepatic-resection-for-hilar-cholangiocarcinoma-a-retrospective-study-of-5-year-survivors
#11
Mohamed Abd ElWahab, Ayman El Nakeeb, Ehab El Hanafy, Ahmad M Sultan, Ahmed Elghawalby, Waleed Askr, Mahmoud Ali, Mohamed Abd El Gawad, Tarek Salah
AIM: To determine predictors of long term survival after resection of hilar cholangiocarcinoma (HC) by comparing patients surviving > 5 years with those who survived < 5 years. METHODS: This is a retrospective study of patients with pathologically proven HC who underwent surgical resection at the Gastroenterology Surgical Center, Mansoura University, Egypt between January 2002 and April 2013. All data of the patients were collected from the medical records...
June 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27343073/mucosa-associated-lymphoid-tissue-malt-lymphoma-as-an-unusual-cause-of-malignant-hilar-biliary-stricture-a-case-report-with-literature-review
#12
REVIEW
Yong Keun Park, Jee Eun Choi, Woon Yong Jung, Sung Kyu Song, Jong In Lee, Chul-Woon Chung
BACKGROUND: Biliary strictures at the hilum of the liver arise from heterogeneous etiologies. The majority is malignant entities, but some may have benign etiologies. It is difficult to distinguish between malignant and benign biliary strictures preoperatively. It has been reported that 5~15 % of preoperative diagnoses of hilar cholangiocarcinoma turn out to be benign lesions or even other types of malignancies. Primary non-Hodgkin's lymphoma of the extrahepatic bile duct is very rare, with only a few cases reported as mucosa-associated lymphoid tissue (MALT) lymphoma arising from the hepatic duct bifurcation...
June 24, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27221813/biliary-brush-cytology-revisited
#13
Shafqat Mehmood, Asif Loya, Muhammed Aasim Yusuf
PURPOSE: To evaluate the diagnostic yield of biliary brush cytology and the factors affecting positive results in patients with biliary strictures. PATIENTS AND METHODS: The medical records of all patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) with biliary brush cytology at our institution from November 2004 to December 2013 were reviewed in this retrospective study. The yield of positive brush cytology and the factors affecting positive yield, such as stricture location, age, gender and preprocedure CA 19...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27190750/clinical-value-of-preoperative-serum-ca-19-9-and-ca-125-levels-in-predicting-the-resectability-of-hilar-cholangiocarcinoma
#14
Hai-Jie Hu, Hui Mao, Yong-Qiong Tan, Anuj Shrestha, Wen-Jie Ma, Qin Yang, Jun-Ke Wang, Nan-Sheng Cheng, Fu-Yu Li
BACKGROUND: To examine the predictive value of tumor markers for evaluating tumor resectability in patients with hilar cholangiocarcinoma and to explore the prognostic effect of various preoperative factors on resectability in patients with potentially resectable tumors. Patients with potentially resectable tumors judged by radiologic examination were included. The receiver operating characteristic (ROC) analysis was conducted to evaluate serum carbohydrate antigenic determinant 19-9 (CA 19-9), carbohydrate antigen 125 (CA 125) and carcino embryonie antigen levels on tumor resectability...
2016: SpringerPlus
https://www.readbyqxmd.com/read/26759510/pulmonary-and-extra-pulmonary-manifestations-of-sarcoidosis
#15
Sasan Tavana, Masoumeh Alizadeh, Seyed Amir Mohajerani, Seyed Mohammadreza Hashemian
BACKGROUND: Sarcoidosis is a systemic multi-organ granulomatous disease of unknown etiology that is characterized by the presence of granuloma in various organs. The clinical features of sarcoidosis are heterogeneous but pulmonary involvement is cardinal manifestations. The aim of this study was to determine radiologic, clinical and laboratory findings of patients with sarcoidosis. PATIENTS AND METHODS: In a cross-sectional study, all patients visiting sarcoidosis clinic were enrolled in the study...
July 2015: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/26427701/cholangiocarcinoma-from-molecular-biology-to-treatment
#16
REVIEW
Ana F Brito, Ana M Abrantes, João C Encarnação, José G Tralhão, Maria F Botelho
Cholangiocarcinoma is a rare tumor originating in the bile ducts, which, according to their anatomical location, is classified as intrahepatic, extrahepatic and hilar. Nevertheless, incidence rates have increased markedly in recent decades. With respect to tumor biology, several genetic alterations correlated with resistance to chemotherapy and radiotherapy have been identified. Here, we highlight changes in KRAS and TP53 genes that are normally associated with a more aggressive phenotype. Also IL-6 and some proteins of the BCL-2 family appear to be involved in the resistance that the cholangiocarcinoma presents toward conventional therapies...
November 2015: Medical Oncology
https://www.readbyqxmd.com/read/26010951/robot-assisted-sialolithotomy-with-sialendoscopy-for-the-management-of-large-submandibular-gland-stones
#17
Christopher Razavi, Celine Pascheles, Ghassan Samara, Mark Marzouk
OBJECTIVES/HYPOTHESIS: The objectives of this study were to describe robot-assisted sialolithotomy with sialendoscopy (RASS) for the management of large palpable hilar submandibular gland (SMG) stones and analyze procedural success and lingual nerve damage following RASS in comparison to the combined transoral sialendoscopic approach. STUDY DESIGN: Retrospective chart review. METHODS: A retrospective chart review was performed on patients with large palpable hilar SMG stones managed with RASS following institutional review board approval...
February 2016: Laryngoscope
https://www.readbyqxmd.com/read/25911877/external-beam-radiation-therapy-with-or-without-concurrent-chemotherapy-for-patients-with-unresectable-locally-advanced-hilar-cholangiocarcinoma
#18
COMPARATIVE STUDY
San-Chi Chen, Ming-Huang Chen, Chung-Pin Li, Ming-Han Chen, Peter Mu-Hsin Chang, Chun-Yu Liu, Cheng-Hwai Tzeng, Yu-Ming Liu, Sang-Hue Yen, Yee Chao, Pin-I Huang
BACKGROUND/AIMS: To evaluate the efficacy of concurrent chemoradiotherapy (CCRT) compared to radiotherapy (RT) for unresectable, locally advanced hilar cholangiocarcinoma (HCCA). METHODOLOGY: Between 2001 and 2010, 34 patients with unresectable locally advanced HCCA at our institute were reviewed. Eighteen patients received RT and 16 patients received CCRT. Survivals and multivariate analyses were performed to explore potential variables affecting survivals. RESULTS: There were 18 males and 16 females, with a median age of 72 years and median follow-up time 9...
January 2015: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25603176/melatonin-stimulates-dendrite-formation-and-complexity-in-the-hilar-zone-of-the-rat-hippocampus-participation-of-the-ca-calmodulin-complex
#19
Aline Domínguez-Alonso, Marcela Valdés-Tovar, Héctor Solís-Chagoyán, Gloria Benítez-King
Melatonin (MEL), the main product synthesized by the pineal gland, stimulates early and late stages of neurodevelopment in the adult brain. MEL increases dendrite length, thickness and complexity in the hilar and mossy neurons of hippocampus. Dendrite formation involves activation of Ca2+/Calmodulin (CaM)-dependent kinase II (CaMKII) by CaM. Previous work showed that MEL increased the synthesis and translocation of CaM, suggesting that MEL activates CaM-dependent enzymes by this pathway. In this work we investigated whether MEL stimulates dendrite formation by CaMKII activation in organotypic cultures from adult rat hippocampus...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25550829/preoperative-serum-ca19-9-levels-is-an-independent-prognostic-factor-in-patients-with-resected-hilar-cholangiocarcinoma
#20
Wen-Ke Cai, Jia-Ji Lin, Gong-Hao He, Hua Wang, Jun-Hua Lu, Guang-Shun Yang
To investigate the appropriate cutoff point of CA19-9 for prognosis and other potential prognostic factors that may affect survival of patients with hilar cholangiocarcinoma (HC) after radical surgery. 168 patients who had undergone radical surgery for hilar cholangiocarcinoma and resultant macroscopic curative resection (R0 and R1) were discreetly selected for analyses. Categorized versions were used in univariate model to determine the appropriate cutoff point of CA19-9. CA19-9 and other clinicopathologic factors were analyzed for influence on survival by univariate and multivariate methods...
2014: International Journal of Clinical and Experimental Pathology
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