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F Ruatta, L Derosa, B Escudier, E Colomba, A Guida, G Baciarello, Y Loriot, K Fizazi, L Albiges
BACKGROUND: Bone metastases (BMs) are associated with significant morbidity and shorter survival in renal cell carcinoma (RCC). Our purpose was to identify prognostic factors for overall survival (OS) in RCC patients with BMs. METHODS: Data from patients with BMs from RCC treated at Gustave Roussy between April 1992 and March 2016 were retrospectively collected. Age, sex, Eastern Cooperative Oncology Group-Performance Status, Memorial Sloan-Kettering Cancer Center (MSKCC) risk groups, histology, number and site of bone lesions, concomitant metastases (presence and sites), therapy for BMs (radical resection or palliative surgery, radiotherapy and other local and systemic treatments) and time from diagnosis to BMs were analysed...
December 11, 2018: European Journal of Cancer
Jared A Mereness, Soumyaroop Bhattacharya, Qian Wang, Yue Ren, Gloria S Pryhuber, Thomas J Mariani
Basement membrane (BM) is an essential part of the extracellular matrix (ECM) that plays a crucial role in mechanical support and signaling to epithelial cells during lung development, homeostasis and repair. Abnormal composition and remodeling of the lung ECM have been associated with developmental abnormalities observed in multiple pediatric and adult respiratory diseases. Collagen VI (COL6) is a well-studied muscle BM component, but its role in the lung and its effect on pulmonary epithelium is largely undetermined...
2018: PloS One
Gemma Molero, Ryan Joynson, Francisco J Pinera-Chavez, Laura-Jayne Gardiner, Carolina Rivera-Amado, Anthony Hall, Matthew P Reynolds
One of the major challenges for plant scientists is increasing wheat (Triticum aestivum) yield potential (YP). A significant bottleneck for increasing YP is achieving increased biomass through optimization of Radiation Use Efficiency (RUE) along the crop cycle. Exotic material such as landraces and synthetic wheat has been incorporated into breeding programs in an attempt to alleviate this, however their contribution to YP is still unclear. To understand the genetic basis of biomass accumulation and RUE we applied genome-wide association study (GWAS) to a panel of 150 elite spring wheat genotypes including many landrace and synthetically derived lines...
December 13, 2018: Plant Biotechnology Journal
Silin Zhang, Yunhe Xiong, Yixian Zhang, Hongmei Zhao
Interactions between the tumor cells and bone marrow (BM) microenvironment promote survival, growth, and chemoresistance of acute myeloid leukemia (AML). The mTOR pathway plays a key role in mediating the AML-BM microenvironment interactions. Here, we report the anti-AML activity of a natural monomer extracted from the Chinese medicinal herb Evodia rutaecarpa, dihydroevocarpine. Our results showed that dihydroevocarpine-induced cytotoxicity, apoptosis, and G0/G1 arrest in AML cells, and inhibited the tumor growth in an AML xenograft model...
December 12, 2018: Journal of Cellular Physiology
Shlomit Yehudai-Resheff, Shira Attias-Turgeman, Rawan Sabbah, Tal Gabay, Raneem Musallam, Anna Friedman-Dror, Tsila Zuckerman
Hematopoietic progenitors, residing in the bone marrow (BM) niche, are supported by mesenchymal stromal cells (MSCs). Cytogenetic and molecular aberrations in these progenitors lead to acute myeloid leukemia (AML). The BM-MSC role in leukemogenesis is not fully elucidated. In the current study, an ex-vivo system of patient's own stroma (POS), best mimicking the in-vivo BM niche, has been developed aiming to unravel interactions and crosstalk between MSCs and AML cells. POS derived from AML patients at diagnosis (Dx), relapse (Rx) and remission (Rm) was compared with healthy donor MSCs in terms of their morphology, growth pattern, support of leukemia cell viability and cytokine profile...
December 13, 2018: International Journal of Cancer. Journal International du Cancer
Kingsley O Asiedu, Munira Ferdousi, Phuongnga T Ton, Stephen S Adler, Peter L Choyke, Noriko Sato
BACKGROUND: Bone fracture healing is dependent upon the rapid migration and engraftment of bone marrow (BM) progenitor and stem cells to the site of injury. Stromal cell-derived factor-1 plays a crucial role in recruiting BM cells expressing its receptor CXCR4. Recently, a CXCR4 antagonist, plerixafor, has been used to mobilize BM cells into the blood in efforts to enhance cell migration to sites of injury presumably improving healing. In this study, we employed zirconium-89 (89 Zr)-oxine-labeled BM cells imaged with positron emission tomography (PET)/computed tomography (CT) to visualize and quantitate BM cell trafficking following acute bone injury and to investigate the effect of plerixafor on BM cell homing...
December 13, 2018: EJNMMI Research
Hui Lin, Xiaoyang Du, Lijuan Li, Caijun Zheng, Silu Tao
A novel pyrene-imidazole derivative (PyPI), which can form effcient π-π stacking in solid film, has been utilized in organic solar cells (OSCs). The stacking of small a molecule PyPI can facilitate a charge transfer and suppress fullerene aggregation. As a result, PTB7-Th: PyPI: PC71 BM based ternary OSC exhibits a high power conversion efficiency (PCE) of 10.36%, which presents a 15.88% increase from the binary device (8.94%). Concurrently, the ternary OSC shows a much better thermal and light illumination stability...
2018: Frontiers in Chemistry
Mohamed-Rachid Boulassel, Zahra Al Qarni, Ikram Burney, Hammad Khan, Abeer Al-Zubaidi, Amal Al Naamani, Huda Al-Hinai, Amira Al-Badi, Rizwan Nabi Qureshi, Vinodh Panjwani, Khalil Al Farsi
Due to their immunoregulatory properties, several specialized cell subsets, including regulatory T (Treg), invariant natural killer T (iNKT) and regulatory B (Breg) cells, are involved in the pathogenesis of non-Hodgkin lymphoma (NHL). However, the interaction between various cells remains to be elucidated. The aim of the present study was to evaluate the levels of Treg, iNKT and Breg cell subsets and their interrelationships in the peripheral blood (PB) and bone marrow (BM) of patients with B-cell NHL who received rituximab-based regimens and achieved a complete remission...
December 2018: Molecular and Clinical Oncology
Fabio Morandi, Alberto L Horenstein, Federica Costa, Nicola Giuliani, Vito Pistoia, Fabio Malavasi
Multiple Myeloma (MM) is a hematological cancer characterized by proliferation of malignant plasma cells in the bone marrow (BM). MM represents the second most frequent hematological malignancy, accounting 1% of all cancer and 13% of hematological tumors, with ~9,000 new cases per year. Patients with monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic smoldering MM (SMM) usually evolve to active MM in the presence of increased tumor burden, symptoms and organ damage. Despite the role of high dose chemotherapy in combination with autologous stem cell transplantation and the introduction of new treatments, the prognosis of MM patients is still poor, and novel therapeutic approaches have been tested in the last years, including new immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies (mAbs)...
2018: Frontiers in Immunology
Pauline Roussille, Gaelle Tachon, Claire Villalva, Serge Milin, Eric Frouin, Julie Godet, Antoine Berger, Sheik Emambux, Christos Petropoulos, Michel Wager, Lucie Karayan-Tapon, David Tougeron
Background: Colorectal cancers (CRC) with brain metastases (BM) are scarcely described. The main objective of this study was to determine the molecular profile of CRC with BM. Methods: We included 82 CRC patients with BM. KRAS , NRAS , BRAF and mismatch repair (MMR) status were investigated on primary tumors ( n = 82) and BM ( n = 38). ALK, ROS1, cMET, HER-2, PD-1, PD-L1, CD3 and CD8 status were evaluated by immunohistochemistry, and when recommended, by fluorescence in situ hybridization. Results: In primary tumors, KRAS , NRAS and BRAF mutations were observed in 56%, 6%, and 6% of cases, respectively...
December 10, 2018: Cancers
Emma L Bostock, Bryn T Edwards, Matthew F Jacques, Jake T S Pogson, Neil D Reeves, Gladys L Onambele-Pearson, Christopher I Morse
The aim of this study was to determine the response to an oral glucose tolerance test (OGTT) in adult males with Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD), and to investigate whether body composition contributes to any variance in the glucose response. Twenty-eight adult males with dystrophinopathy (BMD, n = 13; DMD, n = 15) and 12 non-dystrophic controls, ingested 75 g oral anhydrous glucose solution. Fingertip capillary samples were assessed for glucose at 30-min intervals over 2-h post glucose ingestion...
December 7, 2018: Nutrients
(no author information available yet)
OBJECTIVEAlthough the conformity index (CI) and the gradient index (GI), which were proposed by Paddick and colleagues, are both logically considered to correlate with good posttreatment results after stereotactic radiosurgery (SRS), this hypothesis has not been confirmed clinically. The authors' aim was to reappraise whether high CI values correlate with reduced tumor progression rates, and whether low GI values correlate with reduced complication incidences.METHODSThis was an institutional review board-approved, retrospective cohort study conducted using a prospectively accumulated database including 3271 patients who underwent Gamma Knife SRS for brain metastases (BMs) during the 1998-2016 period...
December 1, 2018: Journal of Neurosurgery
(no author information available yet)
OBJECTIVEWith the aging of the population, increasing numbers of elderly patients with brain metastasis (BM) are undergoing stereotactic radiosurgery (SRS). Among recently reported prognostic grading indexes, only the basic score for brain metastases (BSBM) is applicable to patients 65 years or older. However, the major weakness of this system is that no BM-related factors are graded. This prompted the authors to develop a new grading system, the elderly-specific (ES)-BSBM.METHODSFor this IRB-approved, retrospective cohort study, the authors used their prospectively accumulated database comprising 3267 consecutive patients undergoing Gamma Knife SRS for BMs during the 1998-2016 period at the Mito GammaHouse...
December 1, 2018: Journal of Neurosurgery
Khaled F Al-Massri, Lamiaa A Ahmed, Hanan S El-Abhar
Peripheral neuropathy is a common adverse effect observed during use of paclitaxel (PTX) as chemotherapy. The present investigation was directed to estimate the modulatory effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on pregabalin (PGB) treatment in PTX-induced peripheral neuropathy. Neuropathic pain was induced in rats by injecting PTX (2 mg/kg, i.p) 4 times every other day. Rats were then treated with PGB (30 mg/kg/day, p.o.) for 21 days with or without a single intravenous administration of BM-MSCs...
December 10, 2018: Behavioural Brain Research
Jun Wang, Jie Dai, Xuan Yang, Xiaoya Yu, Steven R Emory, Xueqing Yong, Jinhua Xu, Ling Mei, Jinbing Xie, Ning Han, Xuejin Zhang, Gang Ruan
Quantum dots (QDs) have emerged as a major class of fluorescent probes with unique optical properties, but applying QDs for imaging specific intracellular entities in live cells has been hindered by the poor performance of targeted intracellular delivery of QDs due to various cellular transport barriers. We describe a novel QD nanoprobe design, which is termed a cosolvent-bare hydrophobic QD-biomolecule (cS-bQD-BM, or 'SDot' for short), combining a cosolvent, a bare hydrophobic nanoparticle surface, ultrasmall size and biomolecular function...
December 13, 2018: Nanoscale
Bing Xu, Ian Pelse, Shruti Agarkar, Shunichiro Ito, Junxiang Zhang, Xueping Yi, Yoshiki Chujo, Seth Marder, Franky So, John R Reynolds
Three structurally disordered terpolymer derivatives of PffBT4T-2OD (PCE11), prepared by replacing a varied amount of bithiophene linkers with single thiophenes, were found to exhibit reduced aggregation in solution with increasing thiophene content, while important redox and optoelectronic properties remained similar to those of PffBT4T-2OD. Solar cells based on random terpolymer-PC71 BM blends exhibited average power conversion efficiencies of over 9.5% when processed with preheated substrates, with fill factors above 70%, exceeding those from PffBT4T-2OD...
December 13, 2018: ACS Applied Materials & Interfaces
Xiaoyi Wang, Zongsheng Zhao, Hongwei Zhang, Jixue Hou, Wenlei Feng, Meng Zhang, Jun Guo, Jie Xia, Quanhu Ge, Xueling Chen, Xiangwei Wu
Mesenchymal stem or stromal cells (MSCs) are identified as sources of pluripotent stem cells with varying degrees of plasticity. Endothelial progenitor cells (EPCs) originate from either bone marrow (BM) or peripheral blood and can mature into cells that line the lumen of blood vessels. MSC and EPC therapies exhibit promising results in a variety of diseases. The current study described the simultaneous isolation of EPCs and MSCs from murine BM using a straightforward approach. The method is based on differences in attachment time and trypsin sensitivity of MSCs and EPCs...
December 2018: Experimental and Therapeutic Medicine
Noemi Puig, Bruno Paiva, Marta Lasa, Leire Burgos, Jose J Perez, Juana Merino, Cristina Moreno, Maria-Belen Vidriales, Dolores Gómez Toboso, Maria-Teresa Cedena, Enrique M Ocio, Ramon Lecumberri, Alfonso García de Coca, Jorge Labrador, Maria-Esther Gonzalez, Luis Palomera, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Albert Oriol, Isabel Krsnik, Albert Pérez-Montaña, Javier de la Rubia, Jose-Enrique de la Puerta, Felipe de Arriba, Felipe Prosper, Joaquin Martinez-Lopez, Quentin Lecrevisse, Javier Verde, Maria-Victoria Mateos, Juan-Jose Lahuerta, Alberto Orfao, Jesús F San Miguel
Early diagnosis and risk stratification are key to improve outcomes in light-chain (AL) amyloidosis. Here we used multidimensional-flow-cytometry (MFC) to characterize bone marrow (BM) plasma cells (PCs) from a series of 166 patients including newly-diagnosed AL amyloidosis (N = 94), MGUS (N = 20) and multiple myeloma (MM, N = 52) vs. healthy adults (N = 30). MFC detected clonality in virtually all AL amyloidosis (99%) patients. Furthermore, we developed an automated risk-stratification system based on BMPCs features, with independent prognostic impact on progression-free and overall survival of AL amyloidosis patients (hazard ratio: ≥ 2...
December 12, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Mitsuo Nunome, Keiji Kinoshita, Satoshi Ishishita, Yasushige Ohmori, Atsushi Murai, Yoichi Matsuda
The genetic characteristics and diversity of 21 experimental chicken lines registered with the National BioResource Project of Japan were examined using mitochondrial D-loop sequences and 54 microsatellite DNA markers. A total of 12 haplotypes were detected in the 500-bp mitochondrial DNA sequences of the hypervariable segment I for 349 individuals of 21 lines. The 12 haplotypes belonged to three (A, D, and E) haplogroups, out of the seven (A-H) common haplogroups in domestic chickens and red junglefowls. The haplogroups A and D were widely represented in indigenous chickens in the Asian and Pacific regions, and the haplogroup E was the most prevalent in domestic chickens...
December 13, 2018: Experimental Animals
Akiko Shitara, Lenka Malec, Seham Ebrahim, Desu Chen, Christopher Bleck, Matthew P Hoffman, Roberto Weigert
Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur...
December 12, 2018: Molecular Biology of the Cell
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