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https://www.readbyqxmd.com/read/30103023/17%C3%AE-ethinyl-androst-5-ene-3%C3%AE-17%C3%AE-diol-a-novel-potent-oral-radioprotective-agent-confers-radioprotection-of-hematopoietic-stem-and-progenitor-cells-in-a-granulocyte-colony-stimulating-factor-independent-manner
#1
Fan Bai, Limei Wang, Zhongtang Li, Lirong Yi, Zongchao Zuo, Cheng Zhang, Yajun Shan, Chao Yang, Renjun Peng, Rifang Yang, Zuyin Yu, Yuwen Cong
PURPOSE: The risk of radiation exposure is considered to have increased in recent years. For convenience and simple administration, development of an effective orally administered radioprotective agent is highly desirable. The steroid 5-AED has been evaluated as both a radioprotector and a radiomitigator in mice and nonhuman primates, however, poor oral bioavailability has limited its development, while a variant compound, 17α-Ethinyl-androst-5-ene-3β, 17β-diol (EAD), exhibits significant oral bioavailability...
August 10, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30101404/correction-to-cell-dynamics-during-differentiation-therapy-with-all-trans-retinoic-acid-in-acute-promyelocytic-leukemia
#2
Kazuyuki Sato, Hirotaka Sakai, Yusuke Saiki, Akiko Uchida, Yu Uemura, Satoshi Yokoi, Yuka Tsuruoka, Yuji Nishio, Manabu Matsunawa, Yoshinori Suzuki, Yasushi Isobe, Masayuki Kato, Naoto Tomita, Yasuyuki Inoue, Ikuo Miura
In the original publication of the article, Table 2 was published incorrectly. The column names were swapped under the column heading "Prom (%)". The correct column names are PB and BM.
August 12, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/30100536/clinical-characteristics-and-etiology-of-bacterial-meningitis-in-chinese-children-28-days-of-age-january-2014-december-2016-a-multicenter-retrospective-study
#3
Chi Li, Wen-Ya Feng, Ai-Wei Lin, Guo Zheng, Yan-Chun Wang, Yan-Jun Han, Jian-Min Zhong, Jing Bi, Qiong Luo, Fang-Chao Zhao, Ping Jin, Ling-Yun Guo, Na Li, Jie Yu, Xiao-Tao Yang, Jun Liang, Ji-Kui Deng, Yong-Jun Li, Yu-Jiao Wang, Xiong-Ying Yu, Dong-Meng Wang, Liang Ru, Juan Chen, Yong-Hong Yang, Qiao-Zhi Yang, Gang Liu
OBJECTIVE: To explore the clinical characteristics and etiology of bacterial meningitis (BM) in Chinese children. METHOD: BM cases in children 28days to 18 years old were collected from January 2014-December 2016 and screened according to World Health Organization standards. Clinical features, pathogens, and resistance patterns were analyzed. RESULTS: Overall, 837 cases were classified into five age groups: 28 days-2 months (17.0%), 3-11 months (27...
July 6, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/30100167/distinct-bone-marrow-sources-of-pleiotrophin-control-hematopoietic-stem-cell-maintenance-and-regeneration
#4
Heather A Himburg, Christina M Termini, Lauren Schlussel, Jenny Kan, Michelle Li, Liman Zhao, Tiancheng Fang, Joshua P Sasine, Vivian Y Chang, John P Chute
Bone marrow (BM) perivascular stromal cells and vascular endothelial cells (ECs) are essential for hematopoietic stem cell (HSC) maintenance, but the roles of distinct niche compartments during HSC regeneration are less understood. Here we show that Leptin receptor-expressing (LepR+) BM stromal cells and ECs dichotomously regulate HSC maintenance and regeneration via secretion of pleiotrophin (PTN). BM stromal cells are the key source of PTN during steady-state hematopoiesis because its deletion from stromal cells, but not hematopoietic cells, osteoblasts, or ECs, depletes the HSC pool...
July 30, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/30099697/low-dose-gamma-knife-radiosurgery-plus-whole-brain-radiation-therapy-for-patients-with-5-or-more-brain-metastases-with-or-without-meningeal-dissemination
#5
Akifumi Miyakawa, Yuta Shibamoto, Shinya Takemoto, Tatsuo Hirai, Toru Serizawa
PURPOSE/OBJECTIVE(S): Radiosurgery plus whole-brain radiotherapy (WBRT) has been reported to be useful for patients with ≤ 4 brain metastases (BM), but we hypothesized that similar treatment may be applicable to patients with ≥ 5 BM with or without meningeal dissemination. The purpose of this study was to evaluate the efficacy and toxicity of low-dose Gamma Knife (GK) followed by WBRT for patients with advanced BM. MATERIALS/METHODS: Major eligibility criteria for this phase II study were: (1) ≥ 5 BM with or without meningeal dissemination and (2) the largest tumor diameter ≤ 4 cm...
August 11, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30099609/peak-oxygen-uptake-ventilatory-threshold-and-arterial-stiffness-in-adolescents
#6
Eero A Haapala, Jari A Laukkanen, Tim Takken, Urho M Kujala, Taija Finni
PURPOSE: To investigate the associations of peak oxygen uptake ([Formula: see text]) and [Formula: see text] at ventilatory threshold ([Formula: see text] at VT) with arterial stiffness in adolescents. METHODS: The participants were 55 adolescents (36 girls, 19 boys) aged 16-19 years. Aortic pulse wave velocity (PWVao) and augmentation index (AIx%) were measured by non-invasive oscillometric device from right brachial artery level. [Formula: see text] was directly measured during a maximal ramp test on a cycle ergometer...
August 11, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/30098635/cardiorespiratory-responses-to-heavy-military-load-carriage-over-complex-terrain
#7
David P Looney, William R Santee, Laurie A Blanchard, Anthony J Karis, Alyssa J Carter, Adam W Potter
This study examined complex terrain march performance and cardiorespiratory responses when carrying different Soldier loads. Nine active duty military personnel (age, 21 ± 3 yr; height, 1.72 ± 0.07 m; body mass (BM), 83.4 ± 12.9 kg) attended two test visits during which they completed consecutive laps around a 2.5-km mixed terrain course with either a fighting load (30% BM) or an approach load (45% BM). Respiratory rate and heart rate data were collected using physiological status monitors. Training impulse (TRIMP) scores were calculated using Banister's formula to provide an integrated measure of both time and cardiorespiratory demands...
November 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/30098307/the-effect-of-contralateral-prophylactic-mastectomy-on-breast-related-charges-a-5-year-analysis
#8
Jesse R Smith, Jennifer Jaffe, Jaclyn Pruitt, Katharine Yao, Mark Sisco, Kristine Kuchta, Chi E Wang, Michael A Howard
BACKGROUND AND OBJECTIVES: The purpose of this study was to determine charges following unilateral mastectomy (UM) and bilateral mastectomy (BM) for patients with unilateral breast cancer (UBC). We hypothesized that BM may be associated with fewer charges over time. METHODS: A retrospective review was conducted of patients with UBC treated between 2006 and 2010 with UM and BM in a large healthcare system. Institutional billing data were investigated for 5 years postoperatively to calculate the immediate and subsequent charges of all inpatient and outpatient breast-related care associated with the initial diagnosis for a subset of patients identified using propensity score matching method...
August 11, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30098200/the-corneal-basement-membranes-and-stromal-fibrosis
#9
Carla S Medeiros, Gustavo K Marino, Marcony R Santhiago, Steven E Wilson
Purpose: The purpose of this review was to provide detailed insights into the pathophysiology of myofibroblast-mediated fibrosis (scarring or late haze) after corneal injury, surgery, or infection. Method: Literature review. Results: The epithelium and epithelial basement membrane (EBM) and/or endothelium and Descemet's basement membrane (BM) are commonly disrupted after corneal injuries, surgeries, and infections. Regeneration of these critical regulatory structures relies on the coordinated production of BM components, including laminins, nidogens, perlecan, and collagen type IV by epithelial, endothelial, and keratocyte cells...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30098190/change-of-%C3%AE-zone-parapapillary-atrophy-during-axial-elongation-boramae-myopia-cohort-study-report-3
#10
Kyoung Min Lee, Ho-Kyung Choung, Martha Kim, Sohee Oh, Seok Hwan Kim
Purpose: To investigate changes of β-zone parapapillary atrophy (PPA) during axial elongation. Methods: Change of β-zone PPA was evaluated by spectral-domain optical coherence tomography (SD-OCT) in myopic children for 2 years, prospectively. Using the infrared images acquired by a fixed scan circle in the glaucoma progression analysis (GPA) mode, the retinal pigment epithelial opening (RPEO) and the clinical disc margin (CDM) were manually delineated. The area and position of β-zone PPA was calculated as the differences from those of the RPEO and CDM, respectively...
August 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/30097518/sialidase-down-regulation-reduces-non-hdl-cholesterol-inhibits-leukocyte-transmigration-and-attenuates-atherosclerosis-in-apoe-knockout-mice
#11
Elizabeth J White, Gabriel Gyulay, Šárka Lhoták, Magdalena M Szewczyk, Taryne Chong, Mark T Fuller, Omid Dadoo, Alison E Fox-Robichaud, Richard C Austin, Bernardo Trigatti, Suleiman A Igdoura
Atherosclerosis is a complex disease that involves alterations in lipoprotein metabolism and inflammation. Protein and lipid glycosylation events, such as sialylation, contribute to the development of atherosclerosis and are regulated by specific glycosidases, including sialidases. To evaluate the effect of the sialidase neuraminidase 1 (NEU1) on atherogenesis, here we generated apolipoprotein E (ApoE)-deficient mice that express hypomorphic levels of NEU1 ( Neu1hypo Apoe-/- ). We found that the hypomorphic NEU1 expression in male Apoe-/- mice reduces serum levels of very-low-density lipoprotein (VLDL) and LDL cholesterol, diminishes infiltration of inflammatory cells into lesions, and decreases aortic sinus atherosclerosis...
August 10, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30097155/leucine-rich-alpha-2-glycoprotein-in-the-cerebrospinal-fluid-is-a-potential-inflammatory-biomarker-for-meningitis
#12
Pin Fee Chong, Yasunari Sakai, Hiroyuki Torisu, Tamami Tanaka, Kenji Furuno, Yumi Mizuno, Shouichi Ohga, Toshiro Hara, Ryutaro Kira
BACKGROUND: Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for inflammatory diseases. We evaluated the levels of LRG, interleukin (IL)-6, and tumor necrosis factor (TNF)-α in the cerebrospinal fluid (CSF) of children with meningitis. METHODS: CSF samples from 10 patients with bacterial meningitis (BM) and 10 with aseptic meningitis (AM) were evaluated. Samples from 10 patients with febrile status (FS) were used as controls. LRG levels were measured using a two-site enzyme immunoassay...
September 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30096433/mechanical-stretch-induces-antioxidant-responses-and-osteogenic-differentiation-in-human-mesenchymal-stem-cells-through-activation-of-the-ampk-sirt1-signaling-pathway
#13
Xi Chen, Jinku Yan, Fan He, Dongyan Zhong, Huilin Yang, Ming Pei, Zong-Ping Luo
Mesenchymal stem cells (MSCs) are promising cell sources for regenerative medicine. Growing evidence has indicated that mechanical stimuli are crucial for their lineage-specific differentiation. However, the effect of mechanical loading on redox balance and the intracellular antioxidant system in MSCs was unknown. In this study, human bone marrow-derived MSCs (BM-MSCs) were subjected to cyclic stretch at the magnitude of 2.5%, 5%, and 10%. Cell proliferation, intracellular reactive oxygen species (ROS), expression of antioxidant enzymes, and osteogenic differentiation were evaluated...
August 7, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30095215/mir-182-5p-overexpression-inhibits-chondrogenesis-by-down-regulating-pthlh
#14
Ming Bai, Heping Yin, Jian Zhao, Yang Li, Yimin Wu
BACKGROUND: Human bone marrow mesenchymal stem cells (hBM-MSC) have the ability of differentiating into chondrocytes and osteoblasts. miR-182-5p promotes osteoclastogenesis and bone metastasis by up-regulating the expression of parathyroid hormone-like hormone (PTHLH). However, the function of miR-182-5p in chondrogenesis is still unknown. METHODS: Mimic or inhibitor of miR-182-5p were used to upregulate or knock-down miR-182-5p expression respectively. We analyzed chondrogenesis by Safranin O staining and Blyscan™ Sulfated Glycosaminoglycan Assay...
August 10, 2018: Cell Biology International
https://www.readbyqxmd.com/read/30094224/the-prevention-of-brain-metastases-in-non-small-cell-lung-cancer-by-prophylactic-cranial-irradiation
#15
REVIEW
Willem J A Witlox, Bram L T Ramaekers, Jaap D Zindler, Daniëlle B P Eekers, Judith G M van Loon, Lizza E L Hendriks, Anne-Marie C Dingemans, Dirk K M De Ruysscher
Background: Non-small cell lung cancer (NSCLC) patients frequently develop brain metastases (BM), even though the initial imaging with brain CT or MRI was negative. Stage III patients have the highest risk to develop BM, with an incidence of approximately 30%. BM can lead to neurocognitive disorders, loss of quality of life (QoL), and they are the most important factors influencing patient's overall survival (OS). Although a radical local treatment of BM may be possible with primary radiosurgery or after resection, the prognosis often remains poor...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30092500/t-dm1-and-brain-metastases-clinical-outcome-in-her2-positive-metastatic-breast-cancer
#16
Alessandra Fabi, Daniele Alesini, Enrichetta Valle, Luca Moscetti, Roberta Caputo, Michele Caruso, Luisa Carbognin, Mariangela Ciccarese, Nicla La Verde, Grazia Arpino, Katia Cannita, Ida Paris, Daniele Santini, Filippo Montemurro, Michelangelo Russillo, Gianluigi Ferretti, Gianfranco Filippelli, Rosalba Rossello, Agnese Fabbri, Alberto Zambelli, Vita Leonardi, Anna Maria D'Ottavio, Cecilia Nisticò, Simonetta Stani, Marianna Giampaglia, Giusy Scandurra, Giovanna Catania, Paola Malaguti, Diana Giannarelli, Francesco Cognetti
BACKGROUND: We reported the results of an Italian large retrospective analysis that evaluated the effectiveness and safety of T-DM1 in 'field-practice' breast cancer patients. We performed a sub-analysis to investigate the clinical activity of T-DM1 in patients with brain metastases (BMs). METHODS: The records of 87 adult women with HER2-positive breast cancer and BMs treated with T-DM1 were reviewed. Their clinical outcomes were compared with those of 216 patients without central nervous system (CNS) involvement...
July 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30092306/assessment-of-poly-3-hydroxybutyrate-synthesis-from-a-novel-obligate-alkaliphilic-bacillus-marmarensis-and-generation-of-its-composite-scaffold-via-electrospinning
#17
Tugba Ozgoren, Orkun Pinar, Gulnihal Bozdag, Aziz Akin Denizci, Oguzhan Gunduz, Pinar Cakir Hatir, Dilek Kazan
In this study, poly(3-hydroxybutyrate) (PHB) production from a newly isolated obligate alkaliphilic Bacillus marmarensis DSM 21297 was investigated to evaluate the ability of obligate alkaliphilic strain to produce a biopolymer. Additionally, electrospun nanofibers from B. marmarensis PHB (Bm-PHB) were generated using Bm-PHB/polycaprolactone (PCL) blend to evaluate the applicability of Bm-PHB. According to the experimental results, the metabolic activity of B. marmarensis decreased the pH of the medium by generating H+ ions to initiate Bm-PHB production, which was achieved at pH below 9...
August 6, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30089913/trim44-promotes-quiescent-multiple-myeloma-cell-occupancy-and-survival-in-the-osteoblastic-niche-via-hif-1%C3%AE-stabilization
#18
Zheng Chen, Tsung-Chin Lin, Xiaohong Bi, Guijin Lu, Brian C Dawson, Roberto Miranda, L Jeffrey Medeiros, Ian McNiece, Nami McCarty
Despite progress in the treatment of MM, including the use of high-dose chemotherapy and autologous stem cell transplantation, a considerable proportion of patients are refractory to all therapies. This resistance is related to the molecular genetic heterogeneity in MM cells as well as to the contributions from the BM, which is one of the key determinants of treatment outcome. Our previous studies using fluorescent tracers revealed that MM heterogeneity is correlated with the presence of quiescent stem-like cancer cells, which prefer to reside within the osteoblastic niche of the BM...
August 8, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/30089856/the-effect-of-mesenchymal-stem-cells-secretome-on-lung-cancer-progression-is-contingent-on-their-origin-primary-or-metastatic-niche
#19
Oshrat Attar-Schneider, Liat Drucker, Maya Gottfried
The fatality of non-small-cell lung cancer (NSCLC) and the role of the cancer microenvironment in its resistance to therapy are long recognized. Accumulating data allocate a significant role for mesenchymal stem cells (MSCs) in the malignant environment. Previously, we have demonstrated that MSCs from NSCLC metastatic bone marrow (BM) niche deleteriously affected NSCLC cells. Here, we have decided to examine the effect of MSCs from the primary niche of the lung (healthy or adjacent to tumor) on NSCLC phenotype...
August 8, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/30089200/room-temperature-coherently-coupled-exciton-polaritons-in-two-dimensional-organic-inorganic-perovskite
#20
Jun Wang, Rui Su, Jun Xing, Di Bao, Carole Diederichs, Sheng Liu, Timothy C H Liew, Zhanghai Chen, Qihua Xiong
Two-dimensional (2D) organic-inorganic perovskite semiconductors with natural multi-quantum well structures and confined 2D excitons are intriguing for the study of strong exciton-photon coupling, due to their large exciton binding energy and oscillation strength. This strong coupling leads to a formation of the half-light half-matter bosonic quasiparticle called exciton-polariton, consisting of a linear superposition state between photonic and excitonic states. Here, we demonstrate room temperature strong coupling in exfoliated wavelength-tunable 2D organic-inorganic perovskite semiconductors embedded into a planar microcavity, exhibiting large energetic splitting-to-linewidth ratios (>34...
August 8, 2018: ACS Nano
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