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Elin Borgen, Maria C Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E Lønning, Marit Synnestvedt, Julio A Aguirre-Ghiso, Bjørn Naume
BACKGROUND: The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state over time, but clinical studies of markers predicting the awakening potential of DTCs are lacking. Recently, experiments have shown that NR2F1 (COUP-TF1) plays a key role in dormancy signaling. METHODS: We analyzed the NR2F1 expression in DTCs by double immunofluorescence (DIF) staining of extra cytospins prepared from 114 BM samples from 86 selected DTC-positive breast cancer patients...
October 16, 2018: Breast Cancer Research: BCR
Jie Zhang, Weike Yang, Junfeng Xu, Wanying Yang, Qingrong Li, Yangjin Zhong, Yang Cao, Xiao-Qiang Yu, Xiaojuan Deng
Antimicrobial peptides (AMPs) are important effector molecules of insect humoral immunity, and expression of AMPs is mainly regulated by the Toll and immune deficiency (IMD) pathways. FoxO, a key downstream regulator of the insulin-like signaling (ILS) pathway, has been recently reported to be involved in the regulation of AMPs in Drosophila melanogaster. In the present study, we investigated AMP gene expression and the regulation pathway controlled by the starvation in the silkworm Bombyx mori. We discovered that antibacterial activity in the hemolymph of B...
October 12, 2018: Insect Biochemistry and Molecular Biology
Juliana E Hidalgo-Lόpez, Rashmi Kanagal-Shamanna, Andrés E Quesada, Zimu Gong, Wei Wang, Shimin Hu, L Jeffrey Medeiros, Roland L Bassett, Elizabeth d'Orcy, C Cameron Yin, Jorge Cortes, Elias J Jabbour, Hagop M Kantarjian, Carlos E Bueso-Ramos
BACKGROUND: The diagnosis of chronic myeloid leukemia (CML) is based on characteristic clinical and laboratory findings and the presence of BCR/ABL1 in the blood and/or bone marrow (BM). The utility of BM core biopsy in the workup of patients with CML has been questioned. METHODS: The potential added value of BM biopsy versus aspiration in the workup of a single-institution series of 508 patients with CML at their initial presentation was systematically assessed...
October 15, 2018: Cancer
Ran Miao, Jun Wan, Jie Liu, Jason X-J Yuan, Jing Wang, Wanmu Xie, Zhenguo Zhai, Chen Wang
Purpose: This study aimed to explore whether bone marrow- (BM-) derived endothelial progenitor cells (EPCs) contributing to monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH) in rats via modulating store-operated Ca2+ channels (SOC). Methods: Sprague Dawley (SD) rats were assigned into MCT group (n = 30) and control group (n = 20). Rats in MCT group were subcutaneously administered with 60 mg/kg MCT solution, and rats in control group were injected with equal amount of vehicle...
2018: BioMed Research International
Peter Junghans, Solvig Görs, Martina Langhammer, Cornelia C Metges
We explored a novel doubly labelled water (DLW) method based on breath water (BW-DLW) in mice to determine whole body CO2 production and energy expenditure noninvasively. The BW-DLW method was compared to the DLW based on blood plasma. Mice (n = 11, 43.5 ± 4.6 g body mass (BM)) were administered orally a single bolus of doubly labelled water (1.2 g H2 18 O kg BM-1 and 0.4 g 2 H2 O kg BM-1 , 99 atom% (AP) 18 O or 2 H). To sample breath water, the mice were placed into a respiration vessel. The exhaled water vapour was condensed in a cold-trap...
October 15, 2018: Isotopes in Environmental and Health Studies
David Macutkiewicz, Caroline Sunderland
Team sports, such as field hockey, incorporate high-intensity repeated sprints, interspersed with low-intensity running, which can result in acidosis. The aim of the present study was to examine the effect of acute sodium bicarbonate (SB) supplementation on team sport running and skill performance. Eight elite female field hockey players (age 23 ± 5 years, body mass 62.6 ± 8.4 kg, height 1.66 ± 0.05 m) completed three Field Hockey Skill Tests (FHST) interspersed with four sets of the Loughborough Intermittent Shuttle Test (LIST)...
September 2018: Physiological Reports
Xin-Yue Lian, Ji-Chun Ma, Jing-Dong Zhou, Ting-Juan Zhang, De-Hong Wu, Zhao-Qun Deng, Zhi-Hui Zhang, Xi-Xi Li, Pin-Fang He, Yang Yan, Jiang Lin, Jun Qian
The current study was aimed to investigate integrin beta-like 1 (ITGBL1) methylation pattern and its clinical relevance in patients with acute myeloid leukemia (AML). Real-time methylation-specific polymerase chain reaction (PCR; RQ-MSP) and bisulfite sequencing PCR (BSP) were performed to detect the methylation of ITGBL1 promoter. Real-time quantitative PCR (RT-qPCR) was performed to analyze ITGBL1 transcript level. The results showed that ITGBL1 methylation level in 131 patients with AML was significantly higher than 29 controls (p < 0...
October 14, 2018: Journal of Cellular Physiology
Nazli Jafarzadeh, Zohreh Safari, Majid Pornour, Naser Amirizadeh, Mehdi Forouzandeh Moghadam, Majid Sadeghizadeh
Leukemic cells can impact the bone marrow niche to create a tumor-favorable microenvironment using their secreted factors. Little knowledge is available about immunosuppressive and tumor-promoting properties of chronic myeloid leukemia derived exosomes in bone marrow stromal components. We report here that K562-derived exosomes can affect the gene expression, cytokine secretion, nitric oxide (NO) production, and redox potential of bone marrow mesenchymal stem cells (BM-MSCs) and macrophages. Human BM-MSCs and mouse macrophages were treated with K562-derived exosomes...
October 14, 2018: Journal of Cellular Physiology
Zhijie Wu, Valentina Giudice, Jichun Chen, Wanling Sun, Zenghua Lin, Keyvan Keyvanfar, Nidhi Talasani, Sachiko Kajigaya, Xingmin Feng, Neal S Young
Interleukin (IL)-18, also known as interferon-gamma (INF-γ)-inducing factor, is involved in Th1 responses and regulation of immunity. Accumulating evidence implicates IL-18 in autoimmune diseases, but little is known of its role in acquired aplastic anemia (AA), immune-mediated destruction of bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs). IL-18 protein levels were significantly elevated in sera of severe AA patients, including both responders and non-responders assayed before treatment, and decreased after treatment...
October 11, 2018: Experimental Hematology
Shuai Huang, Yunhe Wang, Si Shen, Yuting Tang, Ancan Yu, Bonan Kang, S Ravi P Silva, Geyu Lu
Polymer solar cells (PSCs) are considered promising energy power suppliers due to their light weight, printability, low-energy fabrication and roll-to-roll processability. Recently, the solution-processed NiOx nanoparticles have been a desirable interfacial material for hole transport in the PSCs, instead of organic semiconductors. However, pure NiOx films restrain the high performance of PSCs due to their poor electrical characteristics caused by the localized orbital distribution at the top of valence band...
October 6, 2018: Journal of Colloid and Interface Science
Philip E Boulais, Toshihide Mizoguchi, Samuel Zimmerman, Fumio Nakahara, Judith Vivié, Jessica C Mar, Alexander van Oudenaarden, Paul S Frenette
The non-hematopoietic cell fraction of the bone marrow (BM) is classically identified as CD45- Ter119- CD31- (herein referred to as triple-negative cells or TNCs). Although TNCs are believed to contain heterogeneous stromal cell populations, they remain poorly defined. Here we showed that the vast majority of TNCs (∼85%) have a hematopoietic rather than mesenchymal origin. Single cell RNA-sequencing revealed erythroid and lymphoid progenitor signatures among CD51- TNCs. Ly6D+ CD44+ CD51- TNCs phenotypically and functionally resembled CD45+ pro-B lymphoid cells, whereas Ly6D- CD44+ CD51- TNCs were enriched in previously unappreciated stromal-dependent erythroid progenitors hierarchically situated between preCFU-E and proerythroblasts...
October 4, 2018: Immunity
Liye Xu, Jin Cheng Song, Xiu Hua Sun, Zi Fen Gao, Li Lv, Jie Zhu
RATIONALE: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history of chronic lymphocytic leukemia (CLL). To our knowledge, this is the first published case of RS of the brain and meninges diagnosed concurrently with CLL in the absence of any evidence of lymphoma outside of the CNS. PATIENT CONCERNS: A 67-year-old female presented with slurred speech, headache, and left-sided hemiparesis...
October 2018: Medicine (Baltimore)
Kyeore Bae, Eunseok Kim, Jeong June Choi, Mi Kyung Kim, Hwa-Seung Yoo
Although anticancer traditional Korean medicine treatment (ACTKMT) is widely applied to patients with cancer together with, or in place of, conventional cancer treatment in Korea, the cohort evidence on its clinical effects is lacking. Therefore, this prospective cohort study is designed to evaluate the effect of ACTKMT on the survival and the clinical outcomes for patients being treated at an integrative oncology clinic.This is a single center, prospective cohort study of patients within 1 year after the diagnosis of primary lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer...
October 2018: Medicine (Baltimore)
XiangHong Li, Wanchang Cui, Lisa Hull, Joan T Smith, Juliann G Kiang, Mang Xiao
In this study, we investigated the effects of low-to-moderate doses of radiation in mice, given our limited understanding of the health risks associated with these exposures. Here, we demonstrate the different responses of the CD2F1 mouse hematopoietic system to low-to-moderate (0.5, 1, 3 or 5 Gy) doses of gamma radiation. After 3 and 5 Gy of 60 Co total-body irradiation (TBI), mouse blood cell counts were decreased and maintained below baseline up to 28-42 days. In contrast, after 0.5 Gy TBI, lymphocyte and monocyte counts increased, and peaked from day 3 to day 14...
October 12, 2018: Radiation Research
Hong Yao, Jiao Wang, Qi Zhou, Xiao-Wen Guan, Yan-Qing Fan, You-Ming Zhang, Tai-Bao Wei, Qi Lin
Chromium(iii) is a kind of microelement and can be converted to the more toxic chromium(vi), which is a carcinogen, by redox cycling. Thus, the development of novel materials for the detection and removal of Cr3+ is a very important issue. A novel metallogel chemosensor (BMG-Fe) based on functionalized benzimidazole (BM) and Fe3+ was constructed, which could fluorescently detect and separate Cr3+. The detection limit of BMG-Fe for Cr3+ is 2.62 × 10-8 M, and it exhibited high sensitivity and selectivity for Cr3+...
October 12, 2018: Soft Matter
Monica Sharma, Seema Tyagi, Preeti Tripathi, Tulika Seth
Background: Syndecan-1 (sCD138) has recently been suggested to predict the clinical course of early-stage chronic lymphocytic leukemia (CLL), but few studies have been reported. This study assessed the role of syndecan-1 in the prognosis of patients with CLL and its correlation with other prognostic markers. Methods: This prospective study was performed in the hematology department of an Indian tertiary care center, over nineteen months (Jun. 2009-Jan. 2011). Forty-nine new patients with CLL presented during this period and were included...
September 2018: Blood Research
Ali Lamin, Jonathan D Oakley, Adam M Dubis, Daniel B Russakoff, Sobha Sivaprasad
PURPOSE: To evaluate longitudinally volume changes in inner and outer retinal layers in early and intermediate age-related macular degeneration (AMD) compared to healthy control eyes using optical coherence tomography (OCT). METHODS: 71 eyes with AMD and 31 control eyes were imaged at two time points: baseline and after 2 years. Automated OCT layer segmentation was performed using OrionTM . This software is able to measure volumes of retinal layers with distinct boundaries including Retinal Nerve Fibre Layer (RNFL), Ganglion Cell-Inner Plexiform Layer (GCIPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptors (PR) and Retinal Pigment Epithelium-Bruch's Membrane complex (RPE-BM)...
October 11, 2018: Eye
Rushikesh S Joshi, Brian R Hirshman, Mir Amaan Ali, Ali Alattar, Kate Carroll, Osamu Nagano, Hitoshi Aiyama, Toru Serizawa, Masaaki Yamamoto, Clark C Chen
BACKGROUND: The disease-specific Graded Prognostic Assessment (ds-GPA) for patients with gastrointestinal (GI) tract cancer brain metastases (BM) suggests Karnofsky Performance Score (KPS) as the only pertinent prognostic factor. We evaluated the prognostic importance of cumulative intracranial tumor volume (CITV). METHODS: KPS, CITV, and overall survival (OS) were collected from consecutive SRS-treated GI BM patients. Patients were grouped into two independent cohorts for development and validation of the model (termed "exploratory" and "validation" cohorts)...
October 8, 2018: World Neurosurgery
Abeer I Abd El-Fattah, M S Zaghloul, N A Eltablawy, L A Rashed
Cardiac injury is a dangerous disease and become a greater issue in the forthcoming decades. The ultimate goal is to prevent the progression of heart failure and apoptotic processes. Cardiac tissue may regenerate itself but to certain extent depending on the number of resident stem cells that is limited. Thus, research had been focused on bone marrow derived stem cells (BM-MSCs) as a promising therapy in different types of tissues, including the heart. This study is designed not only to assess the therapeutic effect of BM-MSCs but also to improve their therapeutic effect in combination with antioxidant α-lipoic acid (ALA) and antihypertensive therapeutic drug form (AP) against isoproterenol-induced cardiac injury and compared with that of BM-MSCs alone...
October 8, 2018: Biochimie
Roberto Luigi Cazzato, Pierre Auloge, Pierre De Marini, Chloé Rousseau, Jeanie Betsy Chiang, Guillaume Koch, Jean Caudrelier, Pramod Rao, Julien Garnon, Afshin Gangi
INTRODUCTION: Percutaneous image-guided cryo- (CA) and radiofrequency- (RFA) ablations have been widely used in the treatment of painful bone metastases (BM). However, paucity of data is available for the performance of these treatments when used with a curative intent. The aim of this study is to investigate the local progression free-survival (LPFS) after radical percutaneous image-guided ablation of BM in oligometastatic patients, and to identify predictive factors associated with local tumor progression...
October 11, 2018: International Journal of Hyperthermia
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