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https://www.readbyqxmd.com/read/30546359/proteasomal-protein-degradation-adaptation-of-cellular-proteolysis-with-impact-on-virus-and-cytokine-mediated-damage-of-heart-tissue-during-myocarditis
#1
REVIEW
Antje Beling, Meike Kespohl
Viral myocarditis is an inflammation of the heart muscle triggered by direct virus-induced cytolysis and immune response mechanisms with most severe consequences during early childhood. Acute and long-term manifestation of damaged heart tissue and disturbances of cardiac performance involve virus-triggered adverse activation of the immune response and both immunopathology, as well as, autoimmunity account for such immune-destructive processes. It is a matter of ongoing debate to what extent subclinical virus infection contributes to the debilitating sequela of the acute disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30545483/cardiac-involvement-by-yellow-fever-from-the-provar-study
#2
Gabriela M M Paixão, Maria Carmo P Nunes, Bruno D V G Beato, Craig Sable, Andrea Z Beaton, Kaciane K B Oliveira, Breno D F Rezende, João Pedro P Rios, Clara L Fraga, Leonardo S Pereira, Maria Rita D Teixeira, Neimy R Oliveira, Marcelo A Pascoal-Xavier, Gustavo V Maciel, Camila Gabriela X Brito, Moacir R Lima Júnior, Antonio Luiz P Ribeiro, Bruno R Nascimento
Incidence of Yellow Fever (YF) has increased in Brazil, and cardiac findings such as bradyarrhythmias and conduction abnormalities have been described. We aimed to perform a comprehensive cardiac evaluation of patients with YF, and to assess the association between cardiac involvement and disease severity. Patients hospitalized with YF from February to March 2018 underwent clinical and laboratory evaluation, focused bedside echocardiography (GE Vivid IQ), electrocardiogram and, in case of alterations, 24-hours Holter...
December 4, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30544481/myocardial-calcification-found-in-epstein-barr-viral-myocarditis-and-rhabdomyolysis-a-case-report
#3
Mingliang Sui, Weibing Tang, Changjiang Wu
RATIONALE: The Epstein-Barr (EB) virus has rarely been reported as a cause of fulminant myocarditis. To our knowledge, the present case is the first report on myocardial calcification in EB viral myocarditis and rhabdomyolysis. PATIENT CONCERNS: A 17-year-old man was admitted to the department with fever, chest tightness, and tachypnea that had been present for 2 days. DIAGNOSES: The initial investigation showed elevated liver enzyme levels, creatine kinase levels, creatine kinase isoenzyme levels, and elevated serum myoglobin...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30544105/effective-ibuprofen-desensitization-in-a-patient-with-myopericarditis
#4
Gabriele Cortellini, Domenico Lippolis, Silvia Amati, Giancarlo Piovaccari, Fabio Cortellini, Giorgio Ballardini
To date, aspirin desensitization is employed with patients with nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbated respiratory diseases (NERD) or with aspirin or NSAIDs hypersensitive patients needing a stent procedure for coronary artery disease. On the other hand, few data exist regarding aspirin desensitization in other cardiological features and particularly we haven't data on different NSAIDs desensitization. Only for NERD patients we have data on ketorolac use. We report an efficacious desensitization procedure for ibuprofen in urticaria/angioedema patient with pericarditis and myocarditis associated...
December 13, 2018: Pharmacology
https://www.readbyqxmd.com/read/30539745/predictors-burden-and-the-impact-of-arrhythmia-on-patients-admitted-for-acute-myocarditis
#5
Oluwole Adegbala, Olakanmi Olagoke, Emmanuel Akintoye, Adeyinka Charles Adejumo, Adegbola Oluwole, Christina Jara, Karlene Williams, Alexandros Briasoulis, Luis Afonso
A significant proportion of patients with acute myocarditis experience sudden cardiac death presumably due to cardiac arrhythmia. In this study, we explore the burden, the predictors of arrhythmia in acute myocarditis and the association between arrhythmias and adverse in-hospital outcomes. After evaluating the frequency of various tachyarrhythmias and bradyarrhythmia in myocarditis population, we built a logistic model to determine the independent predictors of arrhythmias in myocarditis and a 1:1 propensity-matched analysis to examine the impact of arrhythmias...
January 1, 2019: American Journal of Cardiology
https://www.readbyqxmd.com/read/30535006/combined-checkpoint-inhibitor-associated-myocarditis-and-pulmonary-vasculitis-mimicking-acute-pulmonary-embolism
#6
L Baldetti, F Melillo, A Beneduce, P G Camici
No abstract text is available yet for this article.
December 11, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/30533536/concomitant-myasthenia-gravis-myositis-myocarditis-and-polyneuropathy-induced-by-immune-checkpoint-inhibitors-a-life-threatening-continuum-of-neuromuscular-and-cardiac-toxicity
#7
Eugenia Rota, Paola Varese, Sergio Agosti, Lorenzo Celli, Elisabetta Ghiglione, Irene Pappalardo, Gabriele Zaccone, Alba Paglia, Nicola Morelli
No abstract text is available yet for this article.
March 2019: ENeurologicalSci
https://www.readbyqxmd.com/read/30533519/marijuana-induced-myocarditis-a-new-entity-of-toxic-myocarditis
#8
Pramod Theetha Kariyanna, Apoorva Jayarangaiah, Navneet Singh, Teresa Song, Stanley Soroka, Abhimanyu Amarnani, Justina Ray, Samy I McFarlane
Marijuana is the most common drug of abuse in the United States. Marijuana has more than 460 active chemical compounds including δ-9- tetrahydrocannabinol (THC). It acts via the CB1 and CB2 receptors that are distributed in various tissues in the body. Marijuana is known to cause tachycardia, bradycardia, hypertension, to decrease time angina, myocardial infarction and cardiac arrest. Till date, four cases of myocarditis/perimyocarditis associated with marijuana use have been reported. In one such case, it led to the development of heart failure in a young male patient...
2018: American journal of medical case reports
https://www.readbyqxmd.com/read/30526743/clinical-and-laboratory-characteristics-of-an-acute-chikungunya-outbreak-in-bangladesh-in-2017
#9
Md Mujibur Rahman, S K Jakaria Been Sayed, Md Moniruzzaman, A K M Humayon Kabir, Md Uzzal Mallik, Md Rockyb Hasan, Abu Bakar Siddik Zaber, Md Arman Hossain, Nazim Uddin, Md Mehedi Hassan, Fazle Rabbi Chowdhury
From April to September 2017, Bangladesh experienced a huge outbreak of acute Chikungunya virus infection in Dhaka. This series describes the clinical and laboratory features of a large number of cases (690; 399 confirmed and 291 probable) suffered during that period. This observational study was carried out at Dhaka Medical College Hospital, Bangladesh. The median age of the patients at presentation was 38 years (IQR 30-50) with a male (57.3%) predominance. Hypertension and diabetes were the most common comorbidities...
December 10, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30524444/myocarditis-elicits-dendritic-cell-and-monocyte-infiltration-in-the-heart-and-self-antigen-presentation-by-conventional-type-2-dendritic-cells
#10
Katrien Van der Borght, Charlotte L Scott, Liesbet Martens, Dorine Sichien, Gert Van Isterdael, Veronika Nindl, Yvan Saeys, Louis Boon, Burkhard Ludewig, Thierry C Gillebert, Bart N Lambrecht
Autoimmune myocarditis often leads to dilated cardiomyopathy (DCM). Although T cell reactivity to cardiac self-antigen is common in the disease, it is unknown which antigen presenting cell (APC) triggers autoimmunity. Experimental autoimmune myocarditis (EAM) was induced by immunizing mice with α-myosin loaded bone marrow APCs cultured in GM-CSF. APCs found in such cultures include conventional type 2 CD11b+ cDCs (GM-cDC2s) and monocyte-derived cells (GM-MCs). However, only α-myosin loaded GM-cDC2s could induce EAM...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30522885/impact-of-systemic-immune-mediated-diseases-on-clinical-features-and-prognosis-of-patients-with-biopsy-proved-myocarditis
#11
Giovanni Peretto, Simone Sala, Giacomo De Luca, Corrado Campochiaro, Silvia Sartorelli, Alberto M Cappelletti, Stefania Rizzo, Anna Palmisano, Antonio Esposito, Alberto Margonato, Moreno Tresoldi, Gaetano Thiene, Cristina Basso, Lorenzo Dagna, Paolo Della Bella
INTRODUCTION: Myocarditis has been described in association with many systemic immune-mediated diseases (SIDs). However, the role of SIDs in influencing clinical presentation and outcome of patients with a new diagnosis of biopsy-proved myocarditis, has never been investigated so far. METHODS: We enrolled 25 consecutive cases with biopsy-proved myocarditis in the context of SIDs, and controls with isolated myocarditis, matched 1:1 by age, gender, ethnicity and clinical presentation...
November 22, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30518007/-multicenter-investigation-of-extracorporeal-membrane-oxygenation-application-in-pediatric-intensive-care-unit-in-china
#12
G F Yan, X D Cai, C B Zhou, X Y Hong, Y Wang, C M Zhang, Z H Yang, Y C Zhang, Y Cui, Y Q Cui, Y B Cheng, S Y Qian, P F Zhang, Y P Jin, X D Zhu, H Gao, Z P Li, X L Lu, H J Miao, Q Y Zhang, Y M Li, W G Yang, C Y Liu, B Li, Y Li, Z J Bo, J P Chu, X Wang, G P Lu
Objective: To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. Methods: In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. Results: By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals...
December 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/30517546/type-1-cardiorenal-syndrome-in-a-patient-with-an-acute-infection-caused-by-trypanosoma-cruzi-in-the-brazilian-amazon-region-a-case-report
#13
Karla Cristina Petruccelli, Gabriel Castro Tavares, Márcio Pinheiro Lima, Jessica Vanina Ortiz, Alba Regina Brandão, Katia do Nascimento Couceiro, João Marcos Bemfica Barbosa-Ferreira, Mônica Regina Hosannah da Silva E Silva, Maria das Graças Vale Barbosa Guerra, Jorge Augusto de Oliveira Guerra
Cardiorenal syndrome type 1 (CRS 1) occurs when acute heart failure leads to acute kidney injury. There are several etiologies of CRS 1, including Chagas disease. Here, we present the first case report of CRS 1 in a patient with acute Chagas disease. Electrocardiography, transthoracic echocardiography, and cardiac magnetic resonance imaging showed signs of acute myocarditis. Laboratory examination revealed severe loss of kidney function, with a creatinine clearance of 30 mL/min, which fully normalized after treatment...
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/30517383/myocarditis-with-cardiogenic-shock-as-the-first-manifestation-of-systemic-lupus-erythematosus
#14
Jáder Buzati Rebelato, Caroline Ferreira da Silva Mazeto Pupo da Silveira, Tainá Fabri Carneiro Valadão, Fabrício Moreira Reis, Rodrigo Bazan, Silméia Garcia Zanati Bazan
No abstract text is available yet for this article.
December 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/30516409/acute-fulminant-myocarditis-in-a-patient-with-primary-sj%C3%A3-gren-s-syndrome
#15
T Watanabe, Y Takahashi, K Hirabayashi, U Tomaru, M Machida
No abstract text is available yet for this article.
December 5, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/30513031/neonatal-acute-liver-failure-due-to-enteroviruses-a-14-years-single-nicu-experience
#16
Iliana Bersani, Cinzia Auriti, Fiammetta Piersigilli, Andrea Dotta, Francesca Diomedi-Camassei, Alessandra Di Pede, Gabriele Buttinelli, Olivier Danhaive
BACKGROUND: Neonatal acute liver failure (ALF) is a severe condition with a mortality rate up to 70%. Human enterovirus (HEV) infections are associated with serious diseases in newborns, including myocarditis, meningoencephalitis and, more rarely, ALF with a fulminant course. METHODS: Cases of neonatal-onset ALF were identified using the institutional clinical database. The history and clinical data of infants with HEV infection were collected by medical record revision...
December 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30510822/an-out-of-season-case-of-coxsackie-b-myocarditis-with-severe-rhabdomyolysis
#17
Alaap Mehta, Kali Larson, Bindu Sarika Ganapathineedi, Esteffania Villegas, Susmitha Dande, Wahaj Ahmed, Nadew Sebro
A 21-year-old woman was found to have fulminant myocarditis as a result of Coxsackie B infection (a virus shown to exhibit summer-fall seasonality) in mid-December. In this case report, seasonality of enteroviruses is examined, as well as additional factors which may contribute to sporadic cases during winter months. The case report also discusses clinical criteria for endomyocardial biopsy, utility of PCR vs. antibody serological tests, coinfection with multiple serotypes, and rhabdomyolysis in Coxsackie B...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/30508676/fecal-microbiota-transplantation-alleviates-myocardial-damage-in-myocarditis-by-restoring-the-microbiota-composition
#18
Xiao-Fan Hu, Wen-Yong Zhang, Qiang Wen, Wei-Jun Chen, Zhi-Min Wang, Jian Chen, Feng Zhu, Kun Liu, Long-Xian Cheng, Jun Yang, Yan-Wen Shu
Myocarditis can be caused by several infectious and noninfectious causes. Treatment for myocarditis is still a difficult task in clinical practice. The gut microbiota is related to cardiovascular diseases such as atherosclerosis and hypertension. However, little is known about the role of the gut microbiota in myocarditis. In our study, we tested the hypothesis that gut dysbiosis is associated with myocarditis. We focused on whether fecal microbiota transplantation (FMT) can be used as an effective treatment for myocarditis...
November 30, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30505346/leptospirosis-presenting-as-severe-cardiogenic-shock-a-case-report
#19
E Forbat, M J Rouhani, C Pavitt, S Patel, R Handslip, S Ledot
Background: Leptospirosis is a rare infectious illness caused by the Spirochaete Leptospira. It has a wide-varying spectrum of presentation. We present a rare case of severe cardiogenic shock secondary to leptospirosis, in the absence of its common clinical features. Case presentation: A 36-year-old woman presented to our unit with severe cardiogenic shock and subsequent multi-organ failure. Her clinical course was characterised by ongoing pyrexia of unknown origin with concurrent cardiac failure...
November 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/30487991/-salmonella-enteritidis-causing-myocarditis-in-a-previously-healthy-22-year-old-male
#20
Per Sundbom, Anne-Marie Suutari, Karim Abdulhadi, Wojciech Broda, Melinda Csegedi
Myocarditis is mostly caused by viral infections and rarely caused by bacterial pathogens, especially in immunocompetent individuals. Bacterial myocarditis due to Salmonella is rare, especially in countries with improved sanitation that minimize contamination of Salmonella typhi serotypes. We here present a case of a previous healthy 22-year-old male that came to the emergency room with chest pain. His symptoms occurred after a period of profuse diarrhea, fever and hematochezia. Magnetic resonance imaging confirmed the diagnosis of myocarditis...
December 2018: Oxford Medical Case Reports
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