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Yu Wang, Jian Li, Liying Xuan, Yongfeng Liu, Liqun Shao, Hongyan Ge, Junyi Gu, Chengxi Wei, Ming Zhao
BACKGROUND: Viral myocarditis is defined as viral infection of myocardial tissue leading to impaired heart function and heart failure. Accumulating evidences have shown that arrhythmia is one of important complicating diseases of viral myocarditis causing increased mortality and morbidity. There are no effective treatment for the viral infection and complicating arrhythmia. PURPOSE: This study investigated the effect and mechanism of Astragalus Root dry extract (ARDE) on arrhythmia induced by CVB3 in mice...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
V Chung, F J Kos, N Hardwick, Y Yuan, J Chao, D Li, J Waisman, M Li, K Zurcher, P Frankel, D J Diamond
BACKGROUND: Vaccination of cancer patients with p53-expressing modified vaccinia Ankara virus (p53MVA) has shown in our previous studies to activate p53-reactive T cells in peripheral blood but without immediate clinical benefit. We hypothesized that the immunological responses to p53MVA vaccine may require additional immune checkpoint blockade to achieve clinically beneficial levels. We therefore conducted a phase I trial evaluating the combination of p53MVA and pembrolizumab (anti-PD-1) in patients with advanced solid tumors...
August 9, 2018: Clinical & Translational Oncology
Alexandra Perel-Winkler, Sabahat Bokhari, Thania Perez-Recio, Afshin Zartoshti, Anca Askanase, Laura Geraldino-Pardilla
Objectives: Cardiovascular diseaseand heart failure (CHF) are leading causes of death in systemic lupus erythematosus (SLE). The underlying mechanisms for increased CHF in SLE are unclear but myocardial inflammation and lupus myocarditis (LM) may play a role. We propose that 18 F-fluorodeoxyglucose-positron emission tomography (18 F-FDG-PET)/CT can help diagnose LM. Methods: This report describes eight patients with presumed LM; five patients were evaluated due to active cardiorespiratory symptoms and three patients were participating in a pilot study to determine the prevalence of subclinical myocarditis in SLE...
2018: Lupus Science & Medicine
Mehdi Touat, Thierry Maisonobe, Samuel Knauss, Omar Ben Hadj Salem, Baptiste Hervier, Karine Auré, Tali-Anne Szwebel, Nora Kramkimel, Claire Lethrosne, Jean-Frédéric Bruch, Pauline Laly, Jacques Cadranel, Nicolas Weiss, Anthony Béhin, Yves Allenbach, Olivier Benveniste, Timothée Lenglet, Dimitri Psimaras, Werner Stenzel, Sarah Léonard-Louis
OBJECTIVE: To report the clinicopathologic features and outcome of myositis in patients treated with immune checkpoint inhibitors (ICIs) (irMyositis). METHODS: We retrospectively analyzed patients diagnosed with irMyositis in tertiary centers in Paris, France, and Berlin, Germany, from January 2015 to July 2017. Main outcomes were clinical manifestations and muscle histology, which included major histocompatibility complex class I (MHC-I), C5b-9, CD3, CD4, CD8, CD20, CD68, programmed death-1 receptor (PD-1), programmed death ligand (PD-L) 1, and PD-L2 immunohistochemical stains...
August 8, 2018: Neurology
Bettina Baessler, Christian Luecke, Julia Lurz, Karin Klingel, Maximilian von Roeder, Suzanne de Waha, Christian Besler, David Maintz, Matthias Gutberlet, Holger Thiele, Philipp Lurz
Purpose To assess the diagnostic potential of texture analysis applied to T1 and T2 maps obtained with cardiac MRI for the diagnosis of acute infarctlike myocarditis. Materials and Methods This prospective study from August 2012 to May 2015 included 39 participants (overall mean age ± standard deviation, 34.7 years ± 12.2 [range, 18-63 years]; mean age of women, 46.1 years ± 10.8 [range, 24-63 years]; mean age of men, 29.8 years ± 9.2 [range, 18-56 years]) from the Magnetic Resonance Imaging in Myocarditis (MyoRacer) trial with clinical suspicion of acute myocarditis and infarctlike presentation...
August 7, 2018: Radiology
Kristen Nelson McMillan, Narutoshi Hibino, Emily E Brown, Rajeev Wadia, Elizabeth A Hunt, Christi Marshall, Mayuri Alvarez-Machado, Diane Alejo, John D Coulson, William Ravekes, Luca A Vricella
OBJECTIVE: While pediatric HeartWare HVAD application has increased, determining candidacy and timing for initiation of pediatric VAD support has remained a challenge. We present our experience with a systematic approach to HVAD implantation as a bridge to pediatric heart transplantation. METHODS: We performed a retrospective, single center review of pediatric patients (n=11) who underwent HVAD implantation between September 2014 and January 2018. Primary endpoints evaluated were survival to heart transplantation, need for right ventricular assist device (RVAD) at any point, ongoing HVAD support or death...
August 7, 2018: Artificial Organs
Carsten Tschöpe, Sophie Van Linthout, Oliver Klein, Thomas Mairinger, Florian Krackhardt, Evgenij V Potapov, Gunther Schmidt, Daniel Burkhoff, Burkert Pieske, Frank Spillmann
Mechanical circulatory support (MCS) is often required to stabilize patients with acute fulminant myocarditis with cardiogenic shock. This review gives an overview of the successful use of left-sided Impella in the setting of fulminant myocarditis and cardiogenic shock as the sole means of MCS as well as in combination with right ventricular (RV) support devices including extracorporeal life support (ECLS) (ECMELLA) or an Impella RP (BI-PELLA). It further provides evidence from endomyocardial biopsies that in addition to giving adequate support, LV unloading by Impella exhibits disease-modifying effects important for myocardial recovery (i...
August 6, 2018: Journal of Cardiovascular Translational Research
Taylor Dickey, Melanie Schweir, Matthew Hysell
A 34-year-old female reported to the emergency department with a chief complaint of epigastric pain. Initial rapid screening was negative for both influenza A and B. The patient eventually developed myocarditis that led to pulseless ventricular tachycardia and death within 24 hours of admission. Viral smear was positive for influenza B postmortem despite the initial negative rapid screen. This case demonstrates the need for a new diagnostic criteria and treatment strategy for viral myocarditis due to influenza while concisely illustrating how the disease can progress in adults despite commonly presenting as a disease in adolescents...
August 2018: Clinical practice and cases in emergency medicine
Chen Wang, Gabriel Fung, Haoyu Deng, Julienne Jagdeo, Yasir Mohamud, Yuan Chao Xue, Eric Jan, Jeremy A Hirota, Honglin Luo
The role for the NOD-like receptor (NLR) P3 inflammasome in enterovirus infection remains controversial. Available data suggest that the NLRP3 inflammasome is protective against enterovirus A71 but detrimental to the host during coxsackievirus B3 (CVB3) infection. CVB3 is a common etiologic agent associated with myocarditis and pancreatitis. Previous findings on the role of NLRP3 in CVB3 were based primarily on indirect evidence. Here, we utilized NLRP3 knockout mice as well as immune and cardiac cells to investigate the direct interplay between CVB3 infection and NLRP3 activation...
August 6, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Justin C Kao, Adipong Brickshawana, Teerin Liewluck
PURPOSE OF REVIEW: In recent years, immune checkpoint inhibitors have been increasingly used in patients with metastatic cancers with favorable oncological outcomes; however, there have also been increasing number of cancer survivors who have developed immune-related adverse events. Little is known about PD-1 inhibitor-associated neuromuscular complications. RECENT FINDINGS: Neuromuscular disorders are the most common neurological complication reported in PD-1 inhibitor-treated patients...
August 4, 2018: Current Neurology and Neuroscience Reports
S Knauss, L Ginesta Roque, P Hühnchen, L Heinzerling, W Böhmerle, M Endres
BACKGROUND: In recent years the treatment of many tumor entities has been revolutionized by the use of modern immunotherapies with checkpoint inhibitors; however, good response rates are contrasted by many immune-mediated side effects. Neurological immune-mediated side effects are rare but often severe complications of checkpoint inhibitor treatment. METHOD: A systematic search in the PubMed and Web of Sciences databases was carried out for case reports and studies on neurological side effects during checkpoint inhibitor treatment...
August 2, 2018: Der Nervenarzt
N Houari, S Touzani, H Salhi, M-Y Alaoui Lamrani, K Ibnmajdoub, H El Ouahabi, A El Bouazzaoui, B Boukatta, M Maâroufi, K Maazaz, N Kanjaa
Background: Catecholamine-induced cardiogenic shock is a rare manifestation of paragangliomas. The high mortality rate of this condition makes the immediate, multidisciplinary approach mandatory. Case Report: We report a case of an 18-year-old woman with a retroperitoneal secreting paraganglioma, complicated with a cardiogenic shock and an acute adrenergic myocarditis, requiring hemodynamic support and emergency arterial embolization prior to surgical excision, with a favorable outcome...
2018: Case Reports in Critical Care
Masahiro Yamasaki, Takenori Okada, Yoji Sumimoto, Noboru Hattori
Influenza myocarditis is a rare but life-threatening complication of influenza infection. Pneumonitis is a well-known complication of influenza infection, and chest computed tomography (CT) is useful for diagnosing pneumonitis. In addition, myocarditis should be considered in cases of pulmonary congestion observed on chest CT.
October 2018: Respirology Case Reports
Jae Gun Kwak, Sungkyu Cho, Woong-Han Kim
BACKGROUND: Open surgical implantation of epicardial leads in neonates and infants remains the first option of treatment. We reviewed the long-term outcomes after epicardial pacemaker implantation in neonates and infants. METHODS: From 1989 to 2016, 48 patients (16 neonates) underwent pacemaker implantation within the first year of life. Their median age and weight were 66.5days (range: 0∼319 days), and 4.2kg (range: 1.9∼9.3kg), respectively, at the time of first pacemaker implantation...
July 17, 2018: Heart, Lung & Circulation
Sten Skogmar, Johan Tham
BACKGROUND: Diphtheria is caused by Corynebacterium diphtheriae. Although waning in incidence diphtheria can cause severe disease as in this rare Swedish case with several complications. CASE PRESENTATION: A 55-year old male presented to the emergency room with severe respiratory symptoms and greyish membranes in the airways, which turned positive for C. diphtheriae. He was put on ventilator support and remained hospitalized for three months. During care he developed myocarditis and severe neurological disease and he was also co-infected with tuberculosis...
July 31, 2018: BMC Infectious Diseases
Li Yuan, Xiao Chen, Liang Cheng, Man Rao, Kai Chen, Ningning Zhang, Jian Meng, Mengmeng Li, Li-Tao Yang, Ping-Chang Yang, Xin Wang, Jiangping Song
BACKGROUND AND AIMS: Immune deregulation is a causative factor in pathogenesis of myocarditis. Histone deacetylases (HDAC) involve multiple biochemical activities in the cell. This study aims to elucidate the role of HDAC11 in the regulation of interleukin (IL)-13-expression in CD4+ T cells of heart tissue in patients with myocarditis (MCD). METHODS: After heart transplantation, surgically removed hearts were collected from patients with advanced heart failure and MCD or dilated cardiomyopathy (DCM)...
July 28, 2018: Journal of Molecular and Cellular Cardiology
Charles Allderdice, Constantin Marcu, Deepa Kabirdas
No abstract text is available yet for this article.
June 2018: CASE: Cardiovascular Imaging Case Reports
T A Donovan, N Balakrishnan, I Carvalho Barbosa, T McCoy, E B Breitschwerdt, P R Fox
Endomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp. DNA could be amplified more often from the hearts of cats with feline endomyocarditis-left ventricular endocardial fibrosis (FEMC-LVEF) complex compared with cats with hypertrophic cardiomyopathy (HCM) or cats with grossly and microscopically unremarkable hearts (designated non-cardiac disease controls)...
July 2018: Journal of Comparative Pathology
Arpit Agarwal, Suying Lam, Hua Li, Sudheer R Gorla, Nao Sasaki, Paolo G Rusconi, Sethuraman Swaminathan
BACKGROUND: Enlargement of the left atrium is a non-invasive marker of diastolic dysfunction of the left ventricle, a determinant of prognosis in children with cardiomyopathy. Similarly, N-terminal prohormone brain natriuretic peptide is a useful marker in the management of children with cardiomyopathy and heart failure. The aim of this study is to evaluate the association of left atrial pressures with left atrial volume and N-terminal prohormone brain natriuretic peptide in children with cardiomyopathy...
July 31, 2018: Cardiology in the Young
E Nana-Leventaki, M Nana, N Poulianitis, D Sampaziotis, D Perrea, D Sanoudou, D Rontogianni, K Malliaras
BACKGROUND: Cardiosphere-derived cells (CDCs) have yielded promising efficacy signals in early-phase clinical trials of ischemic and nonischemic cardiomyopathy. The potential efficacy of CDCs in acute myocarditis, an inflammatory cardiomyopathy without effective therapy, remains unexplored. Given that CDCs produce regenerative, cardioprotective, anti-inflammatory, and anti-fibrotic effects (all of which could be beneficial in acute myocarditis), we investigated the efficacy of intracoronary delivery of CDCs in a rat model of experimental autoimmune myocarditis...
July 30, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
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