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https://www.readbyqxmd.com/read/30315606/left-ventricular-endocardial-longitudinal-dysfunction-persists-after-acute-myocarditis-with-preserved-ejection-fraction
#1
Gianluca Di Bella, Scipione Carerj, Antonino Recupero, Rocco Donato, Pietro Pugliatti, Gabriella Falanga, Stefano Pedri, Giampiero Vizzari, Mariapaola Campisi, Concetta Zito, Cesare de Gregorio
BACKGROUND: The aim of present study was to assess left ventricular (LV) myocardial deformation and changes over time in patients with acute myocarditis (AM) with preserved ejection fraction detected by late gadolinium enhancement (LGE) magnetic resonance imaging. METHODS: Thirty-five male patients with AM diagnoses and preserved systolic function based on cardiac magnetic resonance imaging (MRI) were prospectively enrolled. On admission, echocardiography with measurements of global and segmental longitudinal (LS) strains was performed both at the endocardial (ENDO) and epicardial (EPI) levels...
October 12, 2018: Echocardiography
https://www.readbyqxmd.com/read/30312637/encephalomyocarditis-virus-2c-protein-antagonizes-interferon-%C3%AE-signaling-pathway-through-interaction-with-mda5
#2
Liang Li, Hui Fan, Zhongbao Song, Xuewei Liu, Juan Bai, Ping Jiang
Encephalomyocarditis virus (EMCV) is one of the most important picornavirus. It infects many mammalian species and causes encephalitis, myocarditis, neurologic diseases, diabetes and reproductive disorders in pigs. And it evolves mechanisms for escaping innate immune responses. But the viral pathogenesis has not been understood completely. In this study, we firstly found that EMCV protein 2C is a strong IFN-β antagonist that interacts with MDA5 to inhibit induction of the IFN-β signal pathway. The mutations in amino acid residue V26 of 2C decrease the inhibition of IFN-β promoter activity and lost the ability to interact with MDA5, compared with wild type 2C protein...
October 9, 2018: Antiviral Research
https://www.readbyqxmd.com/read/30311008/diagnosis-and-management-of-chagas-cardiomyopathy-in-the-united-states
#3
REVIEW
Lillian Benck, Evan Kransdorf, Jignesh Patel
PURPOSE OF REVIEW: Chagas cardiomyopathy is an emerging form of non-ischemic cardiomyopathy in the USA. This review aims to summarize current concepts in pathophysiology, disease transmission, medical therapy, and heart transplantation for patients with chronic Chagas cardiomyopathy. RECENT FINDINGS: The incidence of Chagas cardiomyopathy is increasing in the USA, driven mainly by immigration from countries where Chagas disease is endemic. Chagas cardiomyopathy is a chronic, progressive myocarditis, with hallmark features of biventricular dysfunction, ventricular arrhythmias, thromboembolic complications, and a high risk of mortality...
October 11, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/30306212/the-janus-face-of-hmgb1-in-heart-disease-a-necessary-update
#4
REVIEW
Angela Raucci, Stefania Di Maggio, Francesco Scavello, Alessandro D'Ambrosio, Marco E Bianchi, Maurizio C Capogrossi
High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription regulation, DNA replication and repair and nucleosome assembly. HMGB1 is passively released by necrotic tissues or actively secreted by stressed cells. Extracellular HMGB1 acts as a damage-associated molecular pattern (DAMPs) molecule and gives rise to several redox forms that by binding to different receptors and interactors promote a variety of cellular responses, including tissue inflammation or regeneration. Inhibition of extracellular HMGB1 in experimental models of myocardial ischemia/reperfusion injury, myocarditis, cardiomyopathies induced by mechanical stress, diabetes, bacterial infection or chemotherapeutic drugs reduces inflammation and is protective...
October 10, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/30305575/the-inflammatory-transcription-factor-c-ebp%C3%AE-plays-a-critical-role-in-cardiac-fibroblast-differentiation-and-a-rat-model-of-cardiac-fibrosis-induced-by-autoimmune-myocarditis
#5
Xiu Li, Menghua Sun, Suzhen Men, Yanan Shi, Lijuan Ma, Yongqiang An, Yaqing Gao, Hui Jin, Wei Liu, Zuoyi Du
The aim of the present study was to investigate the mechanisms of CCAAT/enhancer-binding protein β (C/EBPβ) in cardiac myofibroblast (CMF) differentiation and in a rat model of cardiac fibrosis induced by experimental autoimmune myocarditis (EAM).In vitro studies performed in primary neonatal rat CMF revealed that silencing of C/EBPβ expression (via lentiviral mediated shRNA strategies) was sufficient to reduce C/EBPβ mRNA and protein levels as well as to decrease the expressions of actin cytoskeletal proteins, cofilin, and filamin A (FLNA)...
October 10, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30302181/chest-discomfort-in-a-patient-with-dengue-is-it-an-acute-myocardial-infarction
#6
K C Koh, H C Hong
Cardiovascular symptoms presenting in a patient with dengue fever may post a diagnostic dilemma. We describe a case of dengue myocarditis mimicking an acute myocardial infarction in a 56-year-old woman.
2018: Malaysian Family Physician
https://www.readbyqxmd.com/read/30302093/a-very-rare-complication-of-hepatitis-a-infection-acute-myocarditis-a-case-report-with-literature-review
#7
Olivia Allen, Ahmed Edhi, Adam Hafeez, Alexandra Halalau
Hepatitis A is a common viral infection with a benign course but in rare cases can progress to acute liver failure. It usually presents with abdominal pain, nausea, vomiting, diarrhea, jaundice, anorexia, or asymptomatically, but it can also present atypically with relapsing hepatitis and prolonged cholestasis. In addition, extrahepatic manifestations have been reported, including urticarial and maculopapular rash, acute kidney injury, autoimmune hemolytic anemia, aplastic anemia, acute pancreatitis, mononeuritis, reactive arthritis, glomerulonephritis, cryoglobulinemia, Guillain-Barre syndrome, and pleural or pericardial effusion...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/30301732/dress-syndrome-associated-acute-necrotizing-eosinophilic-myocarditis-with-giant-cells
#8
Robert Kowtoniuk, Mamatha Pinninti, William Tyler, Sanjay Doddamani
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an uncommon drug hypersensitivity reaction caused by a wide variety of agents. It has a characteristic latent period between 2 and 8 weeks from the onset of drug ingestion followed by a slow resolution with the potential for relapse. Despite being a potentially fatal disease, little is understood about its variable clinical presentation and why it can present long after removal of the offending drug. Visceral organ involvement typically occurs, but rarely results in clinically manifested cardiac injury...
October 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30297490/uncommon-manifestation-of-leptospirosis-a-diagnostic-challenge
#9
Manasvini Bhatt, Neha Rastogi, Manish Soneja, Ashutosh Biswas
Leptospirosis is a zoonotic disease commonly affecting the tropical countries. It may have protean clinical manifestations including hepatorenal dysfunction, myocarditis, pulmonary haemorrhage, meningitis, optic neuritis and rhabdomyolysis. Neurological manifestation of leptospirosis without the classical hepatorenal dysfunction is a rare entity. This complication of leptospirosis can present with diverse central and peripheral neurological presentations. The overlapping clinical manifestations with many common tropical pathogens often pose diagnostic dilemma and delay in definitive therapy may lead to adverse clinical consequences...
October 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30292432/bridge-to-recovery-in-children-on-ventricular-assist-devices-protocol-predictors-of-recovery-and-long-term-follow-up
#10
Oliver Miera, Matthias Germann, My Y Cho, Joachim Photiadis, Eva M Delmo Walter, Roland Hetzer, Felix Berger, Katharina R L Schmitt
BACKGROUND: The majority of children supported with ventricular assist devices (VADs) are bridged to heart transplantation. Although bridge to recovery has been reported, low recovery patient numbers has precluded systematic analysis. The aim of this study was to delineate recovery rates and predictors of recovery and to report on long-term follow-up after VAD explantation in children. METHODS: Children bridged to recovery at our institution from January 1990 to May 2016 were compared with a non-recovery cohort...
August 11, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30290285/parasitaemia-and-parasitic-load-are-limited-targets-of-the-aetiological-treatment-to-control-the-progression-of-cardiac-fibrosis-and-chronic-cardiomyopathy-in-trypanosoma-cruzi-infected-dogs
#11
Ivo Santana Caldas, Ana Paula de Jesus Menezes, Lívia de Figueiredo Diniz, Álvaro Fernando da Silva do Nascimento, Rômulo Dias Novaes, Sérgio Caldas, Maria Terezinha Bahia
It is still unclear whether the progression of acute to chronic Chagas cardiomyopathy is predominantly associated with the limited efficacy of aetiological chemotherapy, or with the pharmacological resistance profiles and pathogenicity of specific Trypanosoma cruzi strains. Thus, we tested the hypothesis that parasitic load could be a limited target of aetiological chemotherapy to prevent chronic cardiomyopathy in dogs infected by different T. cruzi strains. Animals were infected with benznidazole-susceptible (Berenice-78) and -resistant (VL-10 and AAS) strains of T...
October 2, 2018: Acta Tropica
https://www.readbyqxmd.com/read/30286085/development-of-standard-clinical-endpoints-for-use-in-dengue-interventional-trials
#12
Kay M Tomashek, Bridget Wills, Lucy Chai See Lum, Laurent Thomas, Anna Durbin, Yee-Sin Leo, Norma de Bosch, Elsa Rojas, Kim Hendrickx, Martin Erpicum, Liane Agulto, Thomas Jaenisch, Hasitha Tissera, Piyarat Suntarattiwong, Beth Ann Collers, Derek Wallace, Alexander C Schmidt, Alexander Precioso, Federico Narvaez, Stephen J Thomas, Robert Edelman, João Bosco Siqueira, M Cristina Cassetti, Walla Dempsey, Duane J Gubler
Dengue is a major public health problem worldwide. Although several drug candidates have been evaluated in randomized controlled trials, none has been effective and at present, early recognition of severe dengue and timely supportive care are used to reduce mortality. While the first dengue vaccine was recently licensed, and several other candidates are in late stage clinical trials, future decisions regarding widespread deployment of vaccines and/or therapeutics will require evidence of product safety, efficacy and effectiveness...
October 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30284301/impact-of-atrial-fibrillation-on-patients-hospitalized-for-acute-myocarditis-insights-from-a-nationally-representative-united-states-cohort
#13
Ahmed Subahi, Emmanuel Akintoye, Ahmed S Yassin, Hossam Abubakar, Oluwole Adegbala, Tushar Mishra, Mohamed Abdelrahman, Mohamed Shokr, Luis Afonso
BACKGROUND: Atrial fibrillation (AF) is associated with increased all-cause mortality in the general population. However, the impact of atrial fibrillation on the in-hospital outcomes of acute myocarditis patients is not well characterized. METHODS: Patients (age ≥18 years) with a primary diagnosis of acute myocarditis in the National Inpatient Sample (NIS) from 2007 to 2014 were included, using the ICD-9-CM diagnostic codes. We compared the in-hospital outcomes between the AF group and propensity score-matched control group without AF...
October 3, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30281528/nonrheumatoid-fibrinous-pericarditis-a-medical-examiner-algorithm-for-the-diagnosis-of-viral-myocarditis-and-use-of-molecular-diagnostic-techniques
#14
Avneesh Gupta, Jaclyn Furman, Kilak Kesha, Francisco Diaz, Carl J Schmidt
Classic "bread-and-butter" appearance of fibrinous pericarditis had been described in rheumatic disease and other immunologic diseases such as systemic lupus erythematosus, post-myocardial infarct, uremia, tuberculosis, radiation effects, bacterial, and viral etiology. In most of the described cases, pericarditis occurs as a delayed complication. We present a case of a 21-year-old white woman who was seen in the emergency department to rule out pulmonary embolism for shortness of breath, chest pain, and lightheadedness...
October 2, 2018: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/30281041/-which-role-today-for-intra-aortic-balloon-counterpulsation
#15
Andrea Santucci, Claudio Cavallini
Intra-aortic balloon pump (IABP) is a percutaneous assist device that is easy to implant, is associated with low complication rates and, therefore, is widely used. It is commonly applied by femoral access, although it can be used with axillary access. It reduces afterload and preload, with a slight increase in mean arterial pressure and coronary perfusion. For these characteristics, it has been extensively used in cardiogenic shock, even without a clear demonstration of efficacy from randomized clinical trials; the IABP-SHOCK II study, the largest trial carried out so far, failed to demonstrate the usefulness of IABP in this setting...
October 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/30279934/successfully-treated-eosinophilic-granulomatosis-with-polyangiitis-relapse-presenting-as-myocarditis-and-followed-by-multimodality-imaging
#16
Midori Miyazaki, Hidetoshi Hattori, Atsushi Suzuki, Naoki Serizawa, Kenta Uto, Kenji Fukushima, Mitsuru Momose, Tsuyoshi Shiga, Nobuhisa Hagiwara
A 60-year-old man with eosinophilic granulomatosis with polyangiitis (EGPA), which was diagnosed 12 years earlier and managed with prednisolone, was admitted to our hospital because of dyspnea and paresthesias in both hands. Laboratory test revealed peripheral eosinophilia along with elevated troponin T and brain natriuretic peptide (BNP). The patient's clinical picture was consistent with myocarditis and relapse of EGPA. Endomyocardial biopsy showed marked infiltration of eosinophils in myocardium, which confirmed relapse of EGPA with myocarditis...
October 2018: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30279927/t-wave-alternans-in-a-case-with-systemic-lupus-erythematosus-related-myocarditis
#17
Mikiko Harada, Hirohiko Motoki, Yuichiro Kashima, Chie Nakamura, Naoto Hashizume, Dai Kishida, Hiroshi Imamura, Koichiro Kuwahara
A 42-year-old woman presented with fever, dyspnea, lower-leg edema, significant pulmonary congestion, pleural effusion, and severely reduced left ventricular contractions. She was resistant to treatment for heart failure, including catecholamines, furosemide, phosphodiesterase III inhibitors, and human atrial natriuretic peptide, and antibiotics failed to reduce her inflammation. She had renal dysfunction and hypocomplementemia and was positive for anti-nuclear and anti-ds-DNA antibodies. The patient was diagnosed with myocarditis and pleurisy associated with systemic lupus erythematosus (SLE)...
October 2018: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30279829/mitochondrial-deformity-confined-to-a-single-cardiomyocyte-in-human-endomyocardial-biopsy-specimens-report-of-4-cases
#18
Genzou Takemura, Hiromitsu Kanamori, Hideshi Okada, Akiko Tsujimoto, Nagisa Miyazaki, Shusaku Miyata, Hideaki Ohta, Yoshiaki Kawase, Makoto Ono, Mamoru Mochizuki, Shigeki Kobayashi, Kenji Onoue, Tomoya Nakano, Yasuhiro Sakaguchi, Hitoshi Matsuo, Masafumi Yano, Yoshihiko Saito
During electron microscopic examination of 156 consecutive human endomyocardial biopsy specimens, we found marked mitochondrial deformity within a single cardiomyocyte in each of 4 specimens. The deformed mitochondria were unevenly distributed, but the deformities were confined to the one cardiomyocyte. Those affected cardiomyocytes were accompanied by nonspecific degenerative changes such as nuclear hypertrophy and/or rarefaction of the myofibrils. Mitochondria in all other cells within the specimens appeared normal...
November 2017: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30276425/glucocorticoid-treatment-in-juvenile-idiopathic-arthritis
#19
REVIEW
Ezgi Deniz Batu
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of joints in childhood. Glucocorticoids are being used in JIA treatment effectively for decades. Although systemic glucocorticoid use decreased with the introduction of biologic drugs, intraarticular glucocorticoid injections (IAGI) with nonsteroidal anti-inflammatory drugs and non-biologic disease modifying anti-rheumatic drugs (DMARDs) still remain the primary treatment in JIA, especially in oligoarticular subcategory. Systemic glucocorticoids are used mainly for severe JIA-associated complications such as macrophage activation syndrome (MAS), myocarditis, pericarditis, pleuritis, peritonitis, and severe anemia; as bridging therapy while waiting for the full therapeutic effect of DMARDs; and in certain occasions for patients with severe refractory uveitis...
October 1, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30275798/left-ventricular-aneurysm-presenting-as-bidirectional-ventricular-tachycardia
#20
Abdulah Alrifai, Mohamad Kabach, Jonathan Nieves, Robert Chait
Background: Bidirectional ventricular tachycardia is a rare form of ventricular arrhythmia, characterized by a changing of the mean QRS axis of 180 degrees. Digitalis toxicity is the most common cause of bidirectional ventricular tachycardia; other causes include myocarditis, aconite toxicity, metastatic cardiac tumor, myocardial infarction, and cardiac channelopathies. Case Report: A 73-year-old male with hypertension and a pacemaker implanted for sick sinus syndrome presented with a complaint of substernal chest pressure for several days...
2018: Ochsner Journal
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