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Chronical pancreatitis

Ryohei Kufukihara, Naoya Niwa, Ryuichi Mizuno, Kentaro Ohara, Shuji Mikami, Eiji Kikuchi, Mototsugu Oya
Immunoglobulin G4-related disease (IgG4-RD) is a recently described inflammatory disease with multiorgan involvement. Although there were reports of IgG4-related kidney disease or prostatitis, this disease rarely presents in the bladder. In this report, we describe a case of IgG4-RD arising from bladder wall. This patient had a past history of autoimmune pancreatitis and presented with incidental bladder tumor. Magnetic resonance imaging showed low signal intensity tumor on T2-weighted image, and no invasion to the muscular layer...
December 13, 2018: Urologia Internationalis
Franziska Hanisch, Linda Toresson, Thomas Spillmann
Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Thus, a great number of gastrointestinal diseases like chronic enteropathies, intestinal lymphoma, or exocrine pancreatic insufficiency can lead to hypocobalaminemia...
October 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Michael R Rickels, R Paul Robertson
Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved...
December 12, 2018: Endocrine Reviews
Tetsuya Ito, Shigeyuki Kawa, Akihiro Matsumoto, Kensuke Kubota, Terumi Kamisawa, Kazuichi Okazaki, Kenji Hirano, Yoshiki Hirooka, Kazushige Uchida, Atsuhiro Masuda, Hirotaka Ohara, Kyoko Shimizu, Norikazu Arakura, Atsushi Masamune, Atsushi Kanno, Junichi Sakagami, Takao Itoi, Tetsuhide Ito, Toshiharu Ueki, Takayoshi Nishino, Kazuo Inui, Nobumasa Mizuno, Hitoshi Yoshida, Masanori Sugiyama, Eisuke Iwasaki, Atsushi Irisawa, Tooru Shimosegawa, Tsutomu Chiba
OBJECTIVE: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP. METHODS: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. RESULTS: Of the completed records on 624 type 1 AIP patients, 31 (5%) had experienced pancreatic stones...
January 2019: Pancreas
Ashwin Singh Parihar, Bhagwant Rai Mittal, Shelvin Kumar Vadi, Apurva Sood, Rajender Kumar, Usha Dutta
Groove pancreatitis is a rare form of chronic pancreatitis that affects the groove area adjacent to the second part of the duodenum. Clinical and biochemical features often overlap with other subsets of chronic pancreatitis, while the imaging features resemble that of carcinoma of the head of pancreas. We present a 38-year-old man with abdominal pain, nausea, vomiting, and loss of weight who underwent 18 F-FDG PET/CT to rule out a pancreatic malignancy. PET/CT imaging features of groove pancreatitis are distinct from the other subsets of chronic pancreatitis, such as alcoholic and autoimmune pancreatitis, and helpful in the diagnosis and planning further management of the patient...
December 2018: Nuclear Medicine and Molecular Imaging
Adeline Jacquet, Damien Barbeau, Josiane Arnaud, Samer Hijazi, Florence Hazane-Puch, Frédéric Lamarche, Charline Quiclet, Karine Couturier, Eric Fontaine, Jean-Marc Moulis, Christine Demeilliers
Cadmium (Cd) is a metal which may participate in the development of type II diabetes even if Cd exposure levels are mild. However, experimental studies focusing on daily environmentally relevant doses are scarce, particularly for glucose metabolism of the offspring of chronically exposed mothers. The aim is to measure the impact of maternal low level Cd exposure on glucose and lipid metabolism of offspring. Female rats were exposed to 0, 50 or 500 μ .d-1 of CdCl2 , 21 days before mating and during 21 days of gestation and 21 days of lactation...
November 26, 2018: Chemosphere
Michael Hirth, Christel Weiss, Felix Rückert, Roland H Pfützer, Torsten J Wilhelm, Svetlana Hetjens, Philip D Hardt, Natalia Gubergrits, Matthias P Ebert, Alexander Schneider
OBJECTIVES:  The M-ANNHEIM classification of chronic pancreatitis (CP) stratifies degrees of disease severity according to the M-ANNHEIM-Severity-Score. We aimed to demonstrate the clinical usefulness of the M-ANNHEIM-Severity-Score in quantifying and predicting the frequency of pancreatic surgery, and to establish the M-ANNHEIM-Surgery-Score as a simplified system for patient surveillance regarding the demand of pancreatic surgery. METHODS:  We performed a retrospective, cross-sectional study with 741 CP patients (Mannheim/Germany, n = 537; Gießen/Germany, n = 100; Donetsk/Ukraine, n = 104) categorized according to the M-ANNHEIM classification...
December 2018: Zeitschrift Für Gastroenterologie
Jiguang Ma, Mengwen Xue, Simei Zhang, Liang Cheng, Weikun Qian, Wanxing Duan, Xin Shen
Resveratrol is a type of polyphenol that is abundantly present in knotweed and grapes, and has been confirmed to have tumor‑inhibitory properties. However, the effect of resveratrol on tumor cells under chronic stress conditions remains unclear. The aim of the present study was to demonstrate that resveratrol exerts a significant inhibitory effect on the growth and proliferation of tumor cells under chronic stress in a dose‑dependent manner. Furthermore, resveratrol was able to induce apoptosis of cancer cells under chronic stress conditions...
November 28, 2018: Oncology Reports
Francesco Vitali, Deike Strobel, Luca Frulloni, Marc Heinrich, Lukas Pfeifer, Ruediger Stephan Goertz, Gheorghe Hundorfean, David L Wachter, Robert Gruetzmann, Thomas Bernatik, Markus F Neurath, Dane Wildner
AIMS: Endosonography (EUS) is one of the main diagnostic tools for the differential diagnosis of pancreatic masses. The aim of our study was to describe the value of this technique in the work-up of solid pancreatic lesions, considering the influence of the morphological evidence of pancreatic inflammation in the diagnostic process. MATERIAL AND METHODS: Retrospective analysis of prospectively collected data in our tertiary University center. From March 2007 to October 2015, 218 patients underwent EUS for a suspected solid pancreatic neoplasm (based on previous cross-sectional imaging results, idiopatic acute pancreatitis, weight loss, pancreatic hyperenzymemia, painless jaundice or elevated Ca 19-9 values)...
December 8, 2018: Medical Ultrasonography
Jordan Rowlands, Julian Heng, Philip Newsholme, Rodrigo Carlessi
The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its "incretin effect" in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a broader range of physiological effects in the body. Both in vitro and in vivo studies have demonstrated that GLP-1 mimetics alleviate endoplasmic reticulum stress, regulate autophagy, promote metabolic reprogramming, stimulate anti-inflammatory signaling, alter gene expression, and influence neuroprotective pathways. A substantial body of evidence has accumulated with respect to how GLP-1 and its analogs act to restore and maintain normal cellular functions...
2018: Frontiers in Endocrinology
A G Kriger, S A Budzinsky, M A Zakharova, D S Gorin
Chronic pancreatitis complicated by pancreatic duct stones and pancreatic hypertension, post-necrotic cysts and fistulas requires surgical treatment. There are various procedures from minimally invasive to advanced pancreatectomy. Endoscopic interventions and radical open surgery allow to achieve good results. Successful complex treatment of patient with chronic pancreatitis is presented in this report.
2018: Khirurgiia
Scott M Lippman, Cory Abate-Shen, Karen L Colbert Maresso, Graham A Colditz, Andrew J Dannenberg, Nancy E Davidson, Mary L Disis, Raymond N DuBois, Eva Szabo, Anna R Giuliano, William N Hait, J Jack Lee, Thomas W Kensler, Barnett S Kramer, Paul Limburg, Anirban Maitra, Maria Elena Martinez, Timothy R Rebbeck, Kathryn H Schmitz, Eduardo Vilar, Ernest T Hawk
The recent pace, extent, and impact of paradigm-changing cancer prevention science has been remarkable. The American Association for Cancer Research (AACR) convened a 3-day summit, aligned with five research priorities: (i) Precancer Atlas (PCA). (ii) Cancer interception. (iii) Obesity-cancer linkage, a global epidemic of chronic low-grade inflammation. (iv) Implementation science. (v) Cancer disparities. Aligned with these priorities, AACR co-led the Lancet Commission to formally endorse and accelerate the NCI Cancer Moonshot program, facilitating new global collaborative efforts in cancer control...
December 2018: Cancer Prevention Research
Jichun Yang, Long Jiang Zhang, Fan Wang, Tianpei Hong, Zhaofei Liu
Diabetes is a chronic non-communicable disease affecting over 400 million people worldwide. Diabetic patients are at a high risk of various complications, such as cardiovascular, renal, and other diseases. The pathogenesis of diabetes (both type 1 and type 2 diabetes) is associated with a functional impairment of pancreatic β-cells. Consequently, most efforts to manage and prevent diabetes have focused on preserving β-cells and their function. Advances in imaging techniques, such as magnetic resonance imaging, magnetic resonance spectroscopy, positron emission tomography, and single-photon-emission computed tomography, have enabled noninvasive and quantitative detection and characterization of the population and function of β-cells in vivo...
December 5, 2018: Advanced Drug Delivery Reviews
Francine Bono-Neri, Cara Romano, Anne Isedeh
Cystic fibrosis (CF) is an autosomal recessive genetic disorder resulting from a mutation in the gene which encodes a cellular transmembrane protein channel known as the CF transmembrane conductance regulator. Located systemically on the surface of numerous cells, these altered channels yield multisystem dysfunction. Typical manifestations seen are chronic, progressive, obstructive lung disease, pancreatic insufficiency, CF-related diabetes mellitus, malabsorption and malnutrition, liver disease, and infertility...
October 24, 2018: Journal of Pediatric Health Care
Colin D Johnson, Nicola Williamson, Gwendolyn Janssen-van Solingen, Rob Arbuckle, Chloe Johnson, Sarah Simpson, Doris Staab, Enrique Dominguez-Munoz, Phillippe Levy, Gary Connett, Markus M Lerch
BACKGROUND/OBJECTIVES: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. This study evaluated the psychometric properties of the PEI-Q. METHODS: 162 PEI patients (CF = 71 and CP = 91), 62 diarrhoea-specific irritable bowel syndrome (IBS-D) patients and 60 healthy controls completed the 26-item PEI-Q and the Gastrointestinal Quality of Life Index (GIQLI) at baseline...
November 27, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Suhair Al Salihi, Vanya Jaitly, David M Saulino, Andrew W DuPont, Atilla Ertan, Jamie M Everett, Mamoun Younes
CONTEXT.—: The cause of pancreatic acinar metaplasia (PAM) at the distal esophagus/esophagogastric junction is still controversial. Whereas some authors believe it is congenital, others believe it is acquired because of inflammation of the gastric cardia, and more recently it was proposed to be due to chronic proton pump inhibitor use based on a study in rats. OBJECTIVE.—: To determine whether there is correlation between chronic proton pump inhibitor use and PAM in humans...
December 10, 2018: Archives of Pathology & Laboratory Medicine
Phonthep Angsuwatcharakon, Pimpayao Sodsai, Rungsun Rerknimitr, Nattiya Hirankarn
Background and Aim: The risks of post-ERCP pancreatitis (PEP) are identified as patient- and procedure-related factors. However, the genetic contribution for PEP is still unclear. Recent data show that the polymorphisms of PRSS1-PRSS2 ( rs10273639 ) and MORC4 ( rs12688220 ) are associated with recurrent acute pancreatitis and chronic pancreatitis. We aim to evaluate the association between these polymorphisms and post-ERCP pancreatitis in order to improve better prognosis and better care for these patients...
2018: Gastroenterology Research and Practice
Denis M Nyaga, Mark H Vickers, Craig Jefferies, Jo K Perry, Justin M O'Sullivan
Type 1 diabetes (T1D) is a chronic metabolic disorder characterized by the autoimmune destruction of insulin-producing pancreatic islet beta cells in genetically predisposed individuals. Genome-wide association studies (GWAS) have identified over 60 risk regions across the human genome, marked by single nucleotide polymorphisms (SNPs), which confer genetic predisposition to T1D. There is increasing evidence that disease-associated SNPs can alter gene expression through spatial interactions that involve distal loci, in a tissue- and development-specific manner...
2018: Frontiers in Genetics
Shayal K Chand, Sayali A Pendharkar, Sakina H Bharmal, Adam S Bartlett, Stephen J Pandol, Maxim S Petrov
BACKGROUND & AIMS: Both liver disease (LD) and pancreatitis pose substantial burdens. There have been no general population-based studies on frequency of LD after an episode of pancreatitis. The aim of this study was to investigate the occurrence of LD in a population-based cohort of patients following pancreatitis. METHODS: Nationwide data on the general population of nearly 3 million people were used to identify retrospectively diagnoses of acute pancreatitis, chronic pancreatitis (CP), LD and cirrhosis from 1998 to 2016...
November 16, 2018: Digestive and Liver Disease
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