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One pot synthesis

Jie Liang, Mengnisa Seydimemet, Zulpiya Ghalip, Keyume Ablajan
An efficient and simple procedure for the synthesis of 6-amino-5-cyano-4-phenyl-pyrano[2,3-c]pyrazole-4-carboxylic acid esters was developed via a one-pot reaction of β-ketoester, hydrazine, benzoylacetate, and malononitrile in 50% EtOH catalyzed by InCl3 under ultrasound irradiation. This method is more economic, convenient, nontoxic, and environmentally friendly than established methods of pyranopyrazole synthesis. Target compounds were obtained in excellent yields of up to 95%.
August 17, 2018: Molecular Diversity
M Rajesh Kumar, A Manikandan, A Sivakumar, V Violet Dhayabaran
A green and efficient straightforward tactic for the one-pot regioselective synthesis of novel 10,10-dimethyl-9,10,11,11a-tetrahydro-6H-spiro[chromeno[4,3-b]chromene-7,3'-indoline]-2',6,8 (7aH) -triones (4a-n) in one-pot modus has been established using eco-friendly p-toluenesulphonic acid as catalyst. Among the solvents that were used for synthesis, 4a-n were suitably synthesized with maximum yield (90-98%) in water. We avoided column purification and the formed by-product in the process is environmental-friendly...
August 6, 2018: Bioorganic Chemistry
Marziye Sadat Mirhosseyni, Firouzeh Nemati, Ali Elhampour
AIM AND OBJECTIVE: One of the principles of green chemistry is using inexpensive reagents and catalysts to design green route for synthesis of organic compounds. Recently magnetic nanoparticles have provided a considerable merits. In this study, hollow Fe3O4@Dopamine-SO3H has been successfully applied for the green synthesis of tetrahydrobenzo[b]pyrans and spirooxindoles via one-pot multi-component reaction. MATERIALS AND METHODS: Chemical reagents were purchased from Merck and Aldrich...
August 17, 2018: Combinatorial Chemistry & High Throughput Screening
Yongbo Song, Kelly Lambright, Meng Zhou, Kristin Kirschbaum, Ji Xiang, Andong Xia, Manzhou Zhu, Rongchao Jin
Solving the atomic structure of large-sized metal nanoclusters is a highly challenging task yet critically important for understanding the properties and developing applications. Herein, we report a stable silver nanocluster-Ag146Br2(SR)80 (where R = 4-isopropylbenzenethiol) with its structure solved by X-ray crystallography. Gram-scale synthesis with high yield has been achieved by a one-pot reaction, which offers opportunities for functionalization and applications. This silver nanocluster possesses a core-shell structure with an Ag51 core surrounded by a shell of Ag95Br2S80...
August 16, 2018: ACS Nano
Mrityunjay K Sharma, Roopashri B Acharya, Chinmay A Shukla, Amol A Kulkarni
The multistep flow synthesis of complex molecules has gained momentum over the last few years. A wide range of reaction types and conditions have been integrated seamlessly on a single platform including in-line separation as well as monitoring. Beyond merely getting considered as 'flow version' of conventional 'one-pot synthesis', multistep flow synthesis has become the next generation tool for creating libraries of new molecules. Here we give a more 'engineering' look at the possibility of developing a 'unified multistep flow synthesis platform'...
2018: Beilstein Journal of Organic Chemistry
Stephen A Hill, David Benito-Alifonso, Sean A Davis, David J Morgan, Monica Berry, M Carmen Galan
We report a one-pot, three-minute synthesis of carboxylic acid-decorated fluorescent carbon dots (COOH-FCDs) with tuneable core morphology dependent on the surface passivating agent. Mechanism investigations highlighted the presence of key pyrazine and polyhydroxyl aromatic motifs, which are formed from the degradation of glucosamine in the presence of a bifunctional linker bearing acid and amine groups. The novel COOH-FCDs are selective Fe3+ and hemin sensors. Furthermore, the FCDs are shown to be non-toxic, fluorescent bioimaging agents for cancer cells...
August 15, 2018: Scientific Reports
Óscar Vázquez-Vera, Daniel Segura-Olvera, Mónica A Rincón-Guevara, Atilano Gutiérrez-Carrillo, Miguel A García-Sánchez, Ilich A Ibarra, Leticia Lomas-Romero, Alejandro Islas-Jácome, Eduardo González-Zamora
A series of eight new 5-aryl-benzo[ f ][1,7]naphthyridines were synthesized in 17 to 64% overall yields via an improved MW-assisted cascade-like one pot process (Ugi⁻three component reaction/intramolecular aza-Diels-Alder cycloaddition) coupled to an aromatization process from tri-functional dienophile-containing ester-anilines, substituted benzaldehydes and the chain-ring tautomerizable 2-isocyano-1-morpholino-3-phenylpropan-1-one as starting reagents, under mild conditions. The doubly activated dienophile and the aza-diene functionalities of the eight new Ugi-adducts were exploited to perform an in situ aza-Diels-Alder cycloaddition/aromatization (dehydration/oxidation) process, toward the complex polysubstituted 5-aryl-polyheterocycles, which could be taken as starting point for further SAR studies because the benzo[ f ][1,7]naphthyridine is the core of various bioactive products...
August 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Nailiang Yang, Hongfei Cheng, Xiaozhi Liu, Qinbai Yun, Ye Chen, Bing Li, Bo Chen, Zhicheng Zhang, Xiaoping Chen, Qipeng Lu, Jingtao Huang, Ying Huang, Yun Zong, Yanhui Yang, Lin Gu, Hua Zhang
Similar to heterostructures composed of different materials, possessing unique properties due to the synergistic effect between different components, the crystal-phase heterostructures, one variety of hetero-phase structures, composed of different crystal phases in monometallic nanomaterials are herein developed, in order to explore crystal-phase-based applications. As novel hetero-phase structures, amorphous/crystalline heterostructures are highly desired, since they often exhibit unique properties, and hold promise in various applications, but these structures have rarely been studied in noble metals...
August 14, 2018: Advanced Materials
Salwa Mowafi, Hany Kafafy, Amany Arafa, Karima Haggag, Mohamed Rehan
In this manuscript, we report the simple method to multifunctional wool fiber surfaces. The multifunctional wool fibers were devised with brilliant coloration, antimicrobial activity, and UV-protection property. These multifunctional properties were progressed by in situ assemble of silver nanoparticles (Ag NPs) into the wool fiber surface using green cleaner one-pot route. The proteins existing in the wool fibers acted being a redox active bio-template, facilitating the reduction of Ag+ to Ag0 , with simultaneous binding of the produced Ag NPs both on the surface and within the center of the wool fibers...
August 14, 2018: Environmental Science and Pollution Research International
Lijia Liu, Hongbin Wang, Ziqi Wang, Liangkui Zhu, Lin Huang, Liang Yu, Jinya Fan, Yuechao Yao, Shiyu Liu, Jizhao Zou, Xierong Zeng
Hierarchical FAU zeolites with house-of-card-like (HCL) structures were synthesized through a one-pot organotemplate-free route in the Na2O-Al2O3-SiO2-H2O system. The structure details and formation mechanism of HCL zeolites were determined by the combination of electron crystallography and synthesis chemistry. The results revealed that the unique HCL morphology was attributed to large solution viscosity, and the evolution process obeyed a skeleton crystal growth model due to the limited vortexing effect, which was different from those of the HCL zeolites obtained using organic templates...
August 15, 2018: Chemical Communications: Chem Comm
Fan-Zhi Qu, Chen Zhao, Jia-Qing Cao, Yan Zhang, Yu-Qing Zhao
Based on the fact that 25-OCH3 -PPD, a natural ginsengenin isolated from the leaves of Panax ginseng , is a promising lead compound, novel 25-OCH3 -PPD derivatives were synthesized to find more potent anti-tumor agents by a simple and facile synthetic method. These derivatives were classified into three types and screened for their cytotoxic activities against seven human cancer cell lines. Compared with 25-OCH3 -PPD, compounds a5 , a7 , b5 and b7 exhibited higher anti-tumor activities on all tested cell lines with almost 5-fold to 15-fold increases...
September 1, 2017: MedChemComm
Benjamin Des Soye, Samuel Davidson, Matthew Weinstock, Dan Gibson, Michael C Jewett
A new wave of interest in cell-free protein synthesis (CFPS) systems has shown their utility for producing proteins at high titers, establishing genetic regulatory element libraries (e.g., promoters, ribosome binding sites) in non-model organisms, optimizing biosynthetic pathways before implementation in cells, and sensing biomarkers for diagnostic applications. Unfortunately, most previous efforts have focused on a select few model systems, such as Escherichia coli. Broadening the spectrum of organisms used for CFPS promises to better mimic host cell processes in prototyping applications and open up new areas of research...
August 14, 2018: ACS Synthetic Biology
James N Ayres, Matthew T J Williams, Graham J Tizzard, Simon J Coles, Kenneth B Ling, Louis C Morrill
N-Allenyl cyanamides have been accessed via a one-pot deoxycyanamidation-isomerization approach using propargyl alcohol and N-cyano- N-phenyl- p-methylbenzenesulfonamide. The utility of this novel class of allenamide was explored through derivatization, with hydroarylation, hydroamination, and cycloaddition protocols employed to access an array of cyanamide products that would be challenging to access using existing methods.
August 14, 2018: Organic Letters
An Xiao, Teri J Slack, Yanhong Li, Dashuang Shi, Hai Yu, Wanqing Li, Yang Liu, Xi Chen
Streptococcus pneumoniae sialidase SpNanB is an intramolecular (IT) trans-sialidase and a virulence factor that is essential for streptococcal infection of upper and lower respiratory tract. SpNanB catalyzes the formation of 2,7-anhydro- N-acetylneuraminic acid (2,7-anhydro-Neu5Ac), a potential prebiotic that can be used as the sole carbon source of a common human gut commensal anaerobic bacterium. We report here the development of an efficient one-pot multienzyme (OPME) system for synthesizing 2,7-anhydro-Neu5Ac and its derivatives...
August 14, 2018: Journal of Organic Chemistry
Ashraf A Aly, Alaa A Hassan, Nasr K Mohamed, Mohamed Ramadan, Alan B Brown, Amal S Abd El-Aal, Stefan Bräse, Martin Nieger
A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of amidrazones with ethyl azodicarboxylate and triethylamine (Mitsunobu reagent) in EtOH. This highly regioselective one-pot process provides rapid access to highly diverse triazoles. The reaction was explained, based on Mitsunobu reagent oxidizing ethanol to acetaldehyde, which would then react with amidrazones to give the substituted 3-methyltriazoles. A [2 + 3] cycloaddition reaction between two oxidized forms of amidrazones produced the second type of triazoles...
August 13, 2018: Molecular Diversity
Deepika Singh, Vikas Kumar, Ekta Yadav, Neha Falls, Manvendra Singh, Ujendra Komal, Amita Verma
Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas ( C. carandas ) leaves was studied. Fabrication of AgNPs was confirmed by the UV-visible spectroscopy which gives absorption maxima at 420 nm. C. carandas leaves are the rich source of the bioactive molecules, acts as a reducing and stabilising agent in AgNPs, confirmed by Fourier transforms infrared spectroscopy. The field emission scanning electron microscope revealed the spherical shape of biosynthesised AgNPs...
September 2018: IET Nanobiotechnology
Seungjoo Yi, Won Kyu Lee, Ji-Ho Park, Jae-Seung Lee, Ji-Hun Seo
The goal of this study is to develop a simple one-pot method for the synthesis of a zwitterionic small molecule bearing disulfide moiety, which can effectively inhibit nonspecific protein adsorption on macroscopic and nanoscopic gold surfaces. To this end, the optimal molecular structure of a pyridine disulfide derivative was explored and a zwitterionic small molecule was successfully synthesized from the tertiary amine residue on the pyridine ring through a one-pot method. The coating conditions of the synthesized zwitterionic molecules on the gold surface were optimized through contact angle measurements, and the strong interactions between the gold surface and the disulfide moiety of the zwitterion small molecule were confirmed by surface plasmon resonance (SPR) analysis and X-ray photoelectron spectroscopy...
August 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Xueting Feng, Qingze Jiao, Huiru Cui, Mengmeng Yin, Qun Li, Yun Zhao, Hansheng Li, Wei Zhou, Caihong Feng
The oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are considered to be cornerstones of many energy conversion and storage technologies. It is difficult study high-performance non-precious materials as cost-effective bifunctional electrocatalysts for both the OER and ORR in future practical applications. In this study, NiCo2S4 hollow spheres (NiCo2S4 HSs) were fabricated via an effective and facile one-pot "green" approach in an N,N-dimethylformamide (DMF) - ethylene glycol (EG) binary solution...
August 13, 2018: ACS Applied Materials & Interfaces
Yue Pang, Qiao He, Zi-Qi Li, Ji-Min Yang, Jin-Han Yu, Shou-Fei Zhu, Qi-Lin Zhou
Although transition-metal-catalyzed B-H bond insertion of carbenes into stable borane adducts has emerged as a promising method for or-ganoborane synthesis, all the diazo compounds used to date as carbene precursors have had an electron-withdrawing group to stabilize them. Herein, we report a protocol for rhodium-catalyzed B-H bond insertion reactions of unstabilized diazo compounds generated in situ from to-sylhydrazones. In addition, by using chiral dirhodium catalysts, we also achieved an asymmetric version of the reaction with good to excellent enantioselectivities (up to 98:2 e...
August 13, 2018: Journal of the American Chemical Society
Renaud Zelli, Waël Zeinyeh, Jean-Luc Décout
A one-pot glycosylation and cyclization procedure is described for the synthesis of 6-chloropurine ribonucleosides from chloropyrimidines. From such a procedure and modification of the obtained chloropurine ribonucleosides, many drug candidates or molecular tools for biological study designed from their similarity to naturally occurring nucleosides could be obtained. The synthesis begins by preparation of several amidinoaminochloropyrimidines as precursors for the one-pot procedure. Then, by adding trimethylsilyl trifluoromethanesulfonate (TMSOTf) to a mixture of a pyrimidine and 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribose, different 6-chloropurine ribonucleosides are obtained...
August 13, 2018: Current Protocols in Nucleic Acid Chemistry
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