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One pot synthesis

Tianchao Shi, Feng Qin, Qian Li, Wu Zhang
An efficient copper-catalyzed one-pot three-component reaction of amidines, primary alcohols and secondary alcohols has been developed to synthesize multisubstituted pyrimidines. The significant merits of this method involve high atom efficiency, good functional group tolerance and operational simplicity.
December 5, 2018: Organic & Biomolecular Chemistry
Iu-Fan Chen, Chun-Fu Lu, Wei-Fang Su
Metal-organic frameworks (MOF) are studied extensively in applications like catalysts, gas storage and sensors due to their various functional groups and porous structures. Two-dimensional (2D) MOFs such as triphenylene-based materials show excellent charge transport properties but thin film fabrication and organic ligand synthesis are difficult. In this work, we synthesize thiol-based organic ligand, benzenehexathiol (BHT), by a simple one-pot reaction. This facile method is safer and faster than conventional synthesis procedure that requires using liquid ammonia as solvent...
December 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Alexander J Boddy, Dominic P Affron, Christopher J Cordier, Emma Rivers, Alan C Spivey, James Adam Bull
Methods that provide rapid access to new heterocyclic structures in biologically relevant chemical space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted azetidines, pyrrolidines, piperidines and azepanes bearing ester and diverse aryl substituents. A one-pot rhodium catalyzed N-H insertion and cyclization sequence uses diazo compounds to stitch together linear 1,m-haloamines (m = 2 to 5) to rapidly assemble 4-, 5-, 6- and 7-membered saturated nitrogen heterocycles in excellent yields...
December 5, 2018: Angewandte Chemie
Xin Chen, Huailin Yang, Chunsheng Xiao, Xuesi Chen
Herein, a kind of fluorescent resveratrol nanogels via one-pot thiol-ene Michael addition polymerization of resveratrol triacrylate, 1,6-hexanedithiol, and methoxyl poly(ethylene glycol) acrylate is prepared. The resultant nanogels can be well-dispersed in water with a hydrodynamic radius of around 68 nm, and the nanogels are stable in both water and organic solvents. Moreover, the resveratrol nanogels exhibit elevated fluorescence intensity compared to free resveratrol, and the quantum yield of resveratrol nanogels is estimated to be 5...
December 5, 2018: Macromolecular Bioscience
Malay Patra, Larissa Eichenberger, Gregor Fischer, Jason P Holland
Monoclonal antibodies (mAbs), immunoglobulin fragments and other proteins are important scaffolds in the development of radiopharmaceuticals for diagnostic immuno-positron emission tomography (immuno-PET) and targeted radioimmunotherapy (RIT). Conventional methods for radiolabelling proteins with metal ions like 68Ga, 64Cu, 89Zr, and 90Y etc require multi-step procedures involving pre-purification, functionalisation with a chelate, and subsequent radiolabelling. Standard coupling chemistries are time consuming, difficult to automate, and involve synthesis, isolation and storage of an intermediate, new molecular entity (the conjugated mAb) whose biochemical properties can differ from those of the parent protein...
December 5, 2018: Angewandte Chemie
Swati Parbhakar, Reetam Kaushik, Firasat Hussain
A series of 12 inorganic-organic hybrid 4f-substituted arsenotungstates decorated with 3d-based complexes along with acetate bridging, viz. {[Cu2 (H2 O)(1,10-phen)2 (μ-CH3 COO)2 ]4 [Ln2 (H2 O)2 (μ-CH3 COO)2 (α-AsW11 O39 )2 ]}2- (LnIII = Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu), have been synthesized. These compounds were isolated using a one-pot synthetic strategy with copper, lanthanoid, trilacunary arsenotungstate and 1,10-phenanthroline as precursors. They were characterized using various analytical techniques, such as single-crystal X-ray diffraction (SC-XRD), powder XRD (PXRD), Fourier transform IR (FT-IR) spectroscopy, UV-Vis spectroscopy and thermogravimetric analysis (TGA)...
December 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Hejun An, Shaoyu Mai, Qingqing Xuan, Yao Zhou, Qiuling Song
An expedient strategy for the synthesis of 5-oxazole ketones was developed via homogeneous gold catalysis with 4-MeO-TEMPO as an oxidant. The desired 5-oxazole ketones were achieved in decent yields with excellent functional group compatibility under mild conditions. The current protocol also represents the first example for merging gold catalyst and radical chemistry in one-pot synthesis with internal N-propargylamides.
December 5, 2018: Journal of Organic Chemistry
Yingjie Li, Bolong Huang, Yingjun Sun, Mingchuan Luo, Yong Yang, Yingnan Qin, Lei Wang, Chunji Li, Fan Lv, Weiyu Zhang, Shaojun Guo
The development of cost-efficient, active, and stable electrode materials as bifunctional catalysts for electrochemical water splitting is crucial to high-performance renewable energy storage and conversion devices. In this work, the synthesis of Co-based multi-metal borides nanochains with amorphous structure is reported for boosting the oxygen evolution (OER) and hydrogen evolution reactions (HER) by one-pot NaBH4 reduction of Co2+ , Ni2+ , and Fe2+ under ambient temperature. In all the investigated Co-based metal borides, NiCoFeB nanochains show the excellent OER performance with a low overpotential of 284 mV at 10 mA cm-2 and Tafel slope of 46 mV dec-1 , respectively, together with excellent catalytic stability, and robust HER performance with an overpotential of 345 mV at 10 mA cm-2 ...
December 5, 2018: Small
Arno Verlee, Thomas Heugebaert, Tom van der Meer, Pavel Kerchev, Frank Van Breusegem, Christian V Stevens
Pyrazoles are important heterocyclic compounds with a broad range of biological activities. A new procedure toward tri- or tetrasubstituted pyrazoles has been developed, via a one-pot gold catalyzed synthesis from hydrazines with alkynyl aldehydes or ketones. The reaction proceeds through consecutive hydrazone formation, 5-endo-dig cyclization and an aza-Claisen rearrangement resulting in the desired polysubstitued pyrazoles.
December 5, 2018: Organic & Biomolecular Chemistry
Tianli Yang, Ren He, Guihua Nie, Wenlei Wang, Gui Zhang, Yunchu Hu, Lichao Wu
In this work, carbon quantum dots were first prepared through one-pot hydrothermal route of the propyl aldehyde and sodium hydroxide via an aldol condensation reaction, and a novel solid-phase extraction adsorbent of hollow calcite single crystals was prepared via the precipitation of metal nitrates by the CO2 diffusion method in the presence of CQDs and further applied for excessive Cd(II) ions removal from water. The spectra and morphologies of the etched calcite were investigated by X-ray diffraction, Fourier transform infrared spectrometry, Scanning electron microscope, and Transmission electron microscopy...
December 4, 2018: Scientific Reports
Subramani Sangeetha, Govindasamy Sekar
Copper-catalyzed one-pot synthesis of various 2-arylthiochromenones is developed using xanthate as an odorless sulfur source from easily acquirable 2'-halochalcones. This methodology demonstrates that the cross-coupled product thiochromanone synthesized from 2'-halochalcones (upstream reaction) is oxidized to thiochromenone (downstream reaction) in the same pot using waste byproduct (KI) of the first step as powerful oxidant molecular iodine (I2 ). This one-pot synthesis has been further extended for the synthesis of 3,3'-methylenebisthioflavone using dimethyl sulfoxide (DMSO) as solvent and methylene source...
December 4, 2018: Organic Letters
So Won Youn, Tae Yun Ko, Young Ho Kim, Yun Ah Kim
Regio- and stereoselective synthesis of ( E)-3-arylmethyleneisoindolin-1-ones via Pd(II)/Cu(II)-catalyzed one-pot C-C/C-N bond forming sequence between amides and styrenes is reported. This method provides facile and rapid access to a diverse range of such compounds using readily available starting materials under mild aerobic conditions with good functional group tolerance and high selectivity and efficiency. Further elaboration of the products obtained from this process enabled very short and efficient syntheses of aristolactam and indoloisoquinolinone alkaloids...
December 4, 2018: Organic Letters
Narumi Komami, Keitaro Matsuoka, Ayako Nakano, Masahiro Kojima, Tatsuhiko Yoshino, Shigeki Matsunaga
Monoaryl-λ³-iodanes are potentially attractive arylating agents. They are generally synthesized from aryl iodides via oxidation, which can cause functional group incompatibility, especially when polyfunctionalized derivatives are desired. Here we describe the direct synthesis of monoaryl-λ³-iodanes via a chemoselective ipso-substitution reaction of arylgermanes and arylstannanes with iodine tris(trifluoroacetate). The generated iodanes were converted to iodonium ylides or used for further transformations in one pot...
December 3, 2018: Chemistry: a European Journal
Tao Tong, Xin Wu, Erfei Li, Honglan Kang, Xiaoxia Wang, Xin Lv
A novel and efficient synthesis of 4-iminotetrahydropyrimidin-2-one derivatives was developed through a Cu(I)-catalyzed three-component tandem reaction employing propargylamines, isocyanates and sulfonyl azides as starting materials. A wide range of polysubstituted 4-sulfonyliminotetrahydropyrimidin-2-ones, which might be useful in biological chemistry and medicinal science, were conveniently and efficiently assembled in one pot.
December 3, 2018: Journal of Organic Chemistry
Bing Xiao, Xiaoxuan Zhou, Hongxia Xu, Bihan Wu, Ding Hu, Hongjie Hu, Kanyi Pu, Zhuxian Zhou, Xiangrui Liu, Jianbin Tang, Youqing Shen
Integration of biological macromolecules with inorganic materials via biomineralization has demonstrated great potential for development of nanotheranostic agents. To produce multifunctionality, integration of multiple components in the biomineralized theranostic agents is required; however, how to efficiently and reproducibly implement this is challenging. In this report, a universal biomineralization strategy is developed by incorporation of oxidization polymerization into albumin-templated biomineralization for facile synthesis of nanotheranostic agents...
December 3, 2018: ACS Nano
Jianzhi Huang, Xinrong Guo, Guoqing Yue, Qiong Hu, Lishi Wang
Herein, we successfully synthesized partially oxidized 5 nm cobalt nanoparticles dispersed on single layer nitrogen-doped graphene (denoted as PO-5 nm Co/SL-NG) catalyst by a unique and simple one-pot synthesis strategy, which was efficient applied for highly selective electrocatalytic reduction of carbon dioxide to methanol in 0.1 mol dm-3 aqueous NaHCO3 medium under mild conditions, reaching the maximum faradic efficiency of 71.4% for methanol at -0.90 V versus SCE, possesses strong electrocatalytic current density of 4 mA cm-2 and high yield of 1...
December 3, 2018: ACS Applied Materials & Interfaces
Mengyuan Li, Congli Wang, Zhenghan Di, Hui Li, Jingfang Zhang, Wenting Xue, Meiping Zhao, Ke Zhang, Yuliang Zhao, Lele Li
Developing simple and general approaches for the synthesis of nanometer-sized DNA materials with specific morphologies and functionalities is of significant importance for various applications. Here, we reported, for the first time, a novel approach for the synthesis of a new set of DNA-based nanoarchitectures through coordination-driven self-assembly of Fe(II) ions and DNA molecules. Remarkably, this one-pot supramolecular route is extremely simple and facile. By fine-tuning the assembly, Fe-DNA nanospheres of precise sizes and controlled compositions can be produced...
December 2, 2018: Angewandte Chemie
Erika Rocha-Del Castillo, Omar Gómez-García, Dulce Andrade-Pavón, Lourdes Villa-Tanaca, Teresa Ramírez-Apan, Antonio Nieto-Camacho, Elizabeth Gómez
A series of organotin(IV) complexes was herein prepared and characterized. A one-pot synthetic strategy afforded reasonable to high yields, depending on the nature of the ligand. All new complexes were fully characterized by spectroscopic techniques, consisting of IR, MS and NMR (1 H, 13 C and 119 Sn). The in vitro cytotoxicity tests demonstrated that the organotin complexes produced a greater inhibition, versus cisplatin (the positive control), of the growth of six human cancer cell lines: U-251 (glioblastoma), K-562 (chronic myelogenous leukemia), HCT-15 (colorectal), MCF-7 (breast), MDA-MB-231 (breast) and SKLU-1 (non-small cell lung)...
2018: Chemical & Pharmaceutical Bulletin
Yu Long, Zekun Gao, Jiaheng Qin, Peng Wang, Wei Wu, Lin Zhang, Zhengping Dong, Jiantai Ma
Four types of core-shell materials with magnetic Fe3 O4 microparticles as the core were prepared through different approaches using dopamine, glucose, tetrabutyl orthotitanate (TBOT), and tetraethyl orthosilicate (TEOS) as the shell precursor, respectively. CeO2 nanoparticles (NPs) was successfully immobilized onto these supports to fabricate efficient catalysts for the tandem catalytic synthesis of imines from benzyl alcohols and anilines at low temperature under air atmosphere. The as-prepared catalysts were detailedly characterized by TEM, EDX, XRD, FT-IR, XPS VSM, ICP, and CO2 -TPD...
November 24, 2018: Journal of Colloid and Interface Science
Vijaya Bhaskar, Reshma Chowdary, Sheshagiri R Dixit, Shrinivas D Joshi
β-Secretase (BACE1) has been broadly documented as one of the possible therapeutic targets for the treatment of Alzheimer's disease. In this paper, we report the synthesis and the for β-secretase (BACE-1) inhibitory activity of new series of tetrahydrobenzo [b] pyran derivatives. One-pot synthesis of tetrahydrobenzo [b] pyrans was carried out by condensing aromatic aldehyde, malononitrile and 1,3-cyclohexanedione using ionic liquid 1-butyl-3-methyl imidazolium chloride ([bmIm]Cl- ) in aqueous alcohol media...
November 19, 2018: Bioorganic Chemistry
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