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One pot synthesis

C T Fathimath Salfeena, Basavaraja, K T Ashitha, V Praveen Kumar, Sunil Varughese, Cherumuttathu H Suresh, B S Sasidhar
BF3·OEt2 mediated inverse electron demand Diels-Alder (IEDDA) reaction of chalcones with aryl acetylenes is reported for the synthesis of symmetrical and unsymmetrical 2,4,6-triarylpyrylium ions. The protocol provides an effective one-pot method for the utilization of readily available simple substrates under mild reaction conditions leading to a diverse array of pyrylium ions in moderately good yield.
October 18, 2018: Chemical Communications: Chem Comm
Ali Mohd Ganie, Ayaz Mahmood Dar, Fairooz Ahmad Khan, Bashir Ahmad Dar
Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines...
October 16, 2018: Mini Reviews in Medicinal Chemistry
Cangjie Yang, James P Flynn, Jia Niu
Orthogonal sulfur-fluoride exchange reaction (SuFEx) and copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) are employed to synthesize sequence-regulated synthetic polymers. The high efficiency and broad tolerance of SuFEx and CuAAC to diverse chemical functionalities enable one-pot synthesis of polydispersed sequence-controlled polymers via step-growth copolymerization in high yield and sequence complexity. Furthermore, iterative SuFEx and CuAAC coupling reactions on the solid support without the need of protecting groups afford monodispersed sequence-defined oligomers...
October 16, 2018: Angewandte Chemie
Pabbaraja Srihari, Shweta Singh, Ramesh Samineni, Goverdhan Mehta
A one-pot, transition-metal-free, domino Michael-SNAr protocol of general applicability has been devised for the regioselective synthesis of polyfunctional naphthalenes employing nitromethane and ortho-haloaryl ynones. Utilization of nitromethane as one carbon recursive carbanion source that is subsumed into a variety of ynones to end up as aromatic nitro substituent has been demonstrated. Besides many interesting examples, the application of this domino process towards a total synthesis of polycyclic alkaloid macarpine vouch for the efficacy of this methodology...
October 15, 2018: Angewandte Chemie
Azhar Abbas, Basharat Ali, Kanwal, Khalid Mohammed Khan, Jamshed Iqbal, Shafiq Ur Rahman, Sumera Zaib, Shahnaz Perveen
Benzohydrazide derivatives 1-43 were synthesized via "one-pot" reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1 H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50  = 0.87 ± 0.31-19.0 ± 0.25 µM) as compared to the standard thiourea (IC50  = 21.25 ± 0.15 µM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive...
October 10, 2018: Bioorganic Chemistry
Dengke Wang, Xiang Li, Ling-Ling Zheng, Lu-Mei Qin, Shuang Li, Peng Ye, Yan Li, Jian-Ping Zou
CdS nanoparticle-decorated covalent triazine-based frameworks (CdS NPs/CTF-1) were controllably synthesized via a facile one-pot solvothermal method. Due to the Lewis basic nature of well-defined nitrogen sites in triazine units of CTF-1, highly dispersed and size-controlled CdS NPs were obtained and stabilized on the surface of CTF-1 layers. The as-prepared CdS NPs/CTF-1 assembly showed higher photocatalytic activity in a hydrogen evolution reaction under visible light irradiation as compared with pure CdS and CTF-1 and their physical mixture...
October 15, 2018: Nanoscale
Chen-Chu Wang, Bo-Han Chen, Lu-Yi Lu, Kuo-Sheng Hung, Yuh-Shyong Yang
Protein tyrosine sulfation (PTS), catalyzed by membrane-anchored tyrosylprotein sulfotransferase (TPST), is one of the most common post-translational modifications of secretory and transmembrane proteins. PTS, a key modulator of extracellular protein-protein interactions, accounts for various important biological activities, namely, virus entry, inflammation, coagulation, and sterility. The preparation and characterization of TPST is fundamental for understanding the synthesis of tyrosine-sulfated proteins and for studying PTS in biology...
September 30, 2018: ACS Omega
Rui F P Pereira, Kerstin Zehbe, Christina Günter, Tiago Dos Santos, Sílvia C Nunes, Filipe A Almeida Paz, Maria M Silva, Pedro L Granja, Andreas Taubert, Verónica de Zea Bermudez
New mesoporous silk fibroin (SF)/silica hybrids were processed via a one-pot soft and energy-efficient sol-gel chemistry and self-assembly from a silica precursor, an acidic or basic catalyst, and the ionic liquid 1-butyl-3-methylimidazolium chloride, acting as both solvent and mesoporosity-inducer. The as-prepared materials were obtained as slightly transparent-opaque, amorphous monoliths, easily transformed into powders, and stable up to ca. 300 °C. Structural data suggest the formation of a hexagonal mesostructure with low range order and apparent surface areas, pore volumes, and pore radii of 205-263 m2 g-1 , 0...
September 30, 2018: ACS Omega
Jian Li, Shuyan Song, Yan Long, Shuang Yao, Xin Ge, Lanlan Wu, Yibo Zhang, Xiao Wang, Xiangguang Yang, Hongjie Zhang
By integrating redox self-assembly and redox etching processes, we report a general one-pot strategy for the synthesis of Au@multi-M x O y (M = Co, Ce, Fe, and Sn) yolk@shell nanospheres. Without any additional protecting molecule or reductant, the whole reaction is a clean redox process that happens among the inorganic metal salts in an alkaline aqueous solution. By using this method, Au@Co3 O4 /CeO2 (Au@Co-Ce), Au@Co3 O4 /Fe2 O3 (Au@Co-Fe), and Au@CeO2 /SnO2 (Au@Ce-Sn) yolk@shell nanospheres with binary oxides as shells, Au@Co3 O4 /CeO2 /Fe2 O3 (Au@Co-Ce-Fe) yolk@shell nanospheres with ternary oxides as shells and Au@Co3 O4 /CeO2 /Fe2 O3 /SnO2 (Au@Co-Ce-Fe-Sn) yolk@shell nanospheres with quaternary oxides as shells can be obtained...
October 14, 2018: Chemical Science
Robert Learsch, Garret M Miyake
This work presents a two-step, one-pot process to make star polymers with polywedge arms. In a one-pot reaction, after the polywedge arms are synthesized, crosslinker species are added to the reaction, rapidly forming star polymers. Crosslinker species with different degrees of conformational freedom were designed and synthesized and their capacity to generate star polymers was evaluated. Mass conversions up to 92% and stars with up to 17 arms were synthesized with the most rigid crosslinker. The effects of arm molecular weight and molar ratio of crosslinker to arm on mass conversion and arms per star were explored further...
April 1, 2018: Journal of Polymer Science. Part A, Polymer Chemistry
Bin-Qing He, Xiao-Ye Yu, Peng-Zi Wang, Jia-Rong Chen, Wen-Jing Xiao
A photoredox-catalyzed iminyl radical-triggered C-C bond cleavage/addition/Kornblum oxidation cascade of cycloketone oxime esters and styrenes in DMSO is described. This three-component, one-pot procedure features mild conditions, a broad substrate scope, and high functional group tolerance, providing an efficient approach to access diversely functionalized ketonitriles.
October 15, 2018: Chemical Communications: Chem Comm
Wei-Ting Huang, Yi-Ping Ko, Ting-Yu Kuo, Mikael Larsson, Min-Chih Chang, Ren-Der Jean, Dean-Mo Liu
Magnetic resonance imaging (MRI) has been one of the most frequently-used diagnostic tools with high dimensional precision and positioning accuracy in clinical practices. To achieve contrast enhancement, utilization of high-efficient MR imaging contrast agents becomes a prime consideration and is indispensably reinforced the diagnosis precision, especially for the emerging precision medicine. Gadolinium (Gd)-based complexes has been widely used in current clinical MRI operations, however, numerous side effects were reported and highlighted in clinic...
January 1, 2019: Carbohydrate Polymers
Sara Azad, Bi Bi Fatemeh Mirjalili
The present study describes an efficient and environmentally benign protocol for the synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives. Synthesis is done by one-pot three-component condensation of 2-naphthol, formaldehyde, and primary amines in the presence of Fe3 O4 @nano-cellulose/TiCl as a bio-based magnetic nano-catalyst under solvent-free conditions at room temperature grinding. This green procedure offers the advantages of high yield, short reaction time, environmental friendliness, easy workup, simple magnetic recovery of the catalyst and its reusability up to ten times without significant loss of catalytic activity...
October 12, 2018: Molecular Diversity
Pedro Burguete, José Manuel Morales, Lorenzo Fernández, Jamal El Haskouri, Julio Latorre, Carmen Guillem, Francisco Pérez-Pla, Ana Cros, Daniel Beltrán, Aurelio Beltrán, Pedro Amorós
Mesostructured layered silicas have been prepared through a surfactant-assisted procedure using neutral alkylamines as templates and starting from atrane complexes as hydrolytic inorganic precursors. By adjusting the synthetic parameters, this kinetically controlled reproducible one-pot method allows for obtaining both pure and functionalized (inorganic or organically) lamellar silica frameworks. These are easily deconstructed and built up again, which provides a simple way for expanding the interlamellar space...
October 11, 2018: Nanomaterials
Zhenxing Qin, Wenhai Wang, Xiaozhi Zhan, Xiujuan Du, Qingmei Zhang, Rui Zhang, Kun Li, Jinhong Li, Weiping Xu
Luminescent carbon-based nanoparticles, named often as carbon dots (CDs), were synthesized from citric acid (CA) and guanidine thiocyanate (GITC) via an N and S co-doped hydrothermal procedure. In the present structure characterization, N and S elements could be sufficiently doped by means of the heteroatom or the functional groups bonded on the surface of CDs. The as-prepared CDs solution showed blue color fluorescence under ultraviolet excitation, yet the PL spectra exhibited a repetitive emission process from excitation-independent to excitation-dependent...
October 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Mengting Liu, Wenjuan Ma, Qianshun Li, Dan Zhao, Xiaoru Shao, Qian Huang, Liying Hao, Yunfeng Lin
OBJECTIVES: Aptamer sgc8c is a short DNA sequence that can target protein tyrosine kinase 7 (PTK7), which was overexpressed on many tumour cells. This study aimed to fabricate a novelty DNA nanostructure drug delivery system target on PTK7-positive cells-CCRF-CEM (human T-cell ALL). METHODS: Aptamer-modified tetrahedron DNA was synthesized through one-step thermal annealing process. The sgc8c-TDNs (s-TDNs) loading DOX complexes were applied to investigate the effect to PTK7-negative and -positive cells...
October 12, 2018: Cell Proliferation
Arthur Martens, Philippe Weis, Michael Christian Krummer, Marvin Kreuzer, Andreas Meierhöfer, Stefan C Meier, Jan Bohnenberger, Harald Scherer, Ian Riddlestone, Ingo Krossing
By reaction of the Lewis acid Me3 Si-F-Al(ORF )3 with a series of [PF6 ]- salts, gaseous PF5 and Me3 Si-F are liberated and salts of the anion [F-Al(ORF )3 ]- ([f-al]- ; RF = C(CF3 )3 ) can be obtained. By addition of another equivalent of Me3 Si-F-Al(ORF )3 to [f-al]- , gaseous Me3 Si-F is released and salts of the least coordinating anion [(RF O)3 Al-F-Al(ORF )3 ]- ([al-f-al]- ) are formed. Both procedures work for a series of synthetically useful cations including Ag+ , [NO]+ , [Ph3 C]+ and in very clean reactions with 5 g batch sizes giving excellent yields typically exceeding 90%...
September 21, 2018: Chemical Science
Supriya Dey, Chi-Huey Wong
Heparin (H) and heparan sulfate (HS) belong to the glycosaminoglycan (GAG) family of oligosaccharides, and their sequences and sulfation patterns are known to regulate the functions of various proteins in biological processes. Among these, the 6- O -sulfation of HS/H contributes most significantly to the structural diversity and binding interactions. However, the synthesis of HS with defined sulfation patterns remains a major challenge. Herein, we report a highly efficient and programmable one-pot method for the synthesis of protected heparin pentasaccharides using thioglycoside building blocks with optimized relative reactivities to allow the selective deprotection and preparation of regiodefined sulfate derivatives...
August 28, 2018: Chemical Science
Hairong Lyu, Yangjian Quan, Zuowei Xie
A one-pot strategy for efficient and facile synthesis of C,B-substituted carborane-fused N-polyheterocycles is reported. A rhodium catalyzed cascade cyclization of carboranyl N-arylimines with vinyl ketones enables the effective construction of three new B-C and C-C bonds in one reaction. Both carboranyl B-H and aryl C-H bonds are sequentially activated, leading to a series of previously unavailable C,B-substituted carborane-fused cyclopenta[ b ]quinoline derivatives, for potential applications in pharmaceuticals and materials, in a step-economical manner...
August 14, 2018: Chemical Science
Zhongyi Zeng, Hongming Jin, Matthias Rudolph, Frank Rominger, A Stephen K Hashmi
We herein describe a facile, site-selective and divergent approach to construct 2-aminopyrroles and quinoline-fused polyazaheterocycles enabled by a simple gold(III) catalyst from ynamides and anthranils under mild reaction conditions. This one-pot strategy uses readily available starting materials, proceeds in a highly step- and atom-economical manner, with broad substrate scope and scale-up potential. The key element for success in this tandem reaction is a catalyst-directed preferred quenching of the in-situ generated gold carbene intermediates by a nucleophilic benzyl/2-furylmethyl moiety on the ynamides as an alternative to the known C-H annulation leading to indoles...
October 11, 2018: Angewandte Chemie
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