keyword
MENU ▼
Read by QxMD icon Read
search

Humanities

keyword
https://www.readbyqxmd.com/read/28724269/association-of-human-methionine-synthase-a2756g-transition-with-prostate-cancer-a-case-control-study-and-in-silico-analysis
#1
Arezou Ebrahimi, Abasalt Hosseinzadeh Colagar, Mohammad Karimian
Methionine synthase (MTR) is one of the key enzymes of folate pathway, which play a key role in the construction, repair, and methylation of DNA. In this study, an association of MTR A2756G gene transition with prostate cancer in men populations of Kashan-Iran was investigated by a case-control study and an in silico analysis. The 200 samples including 100 patients with prostate cancer, as case group and 100 healthy men, as control group included in this study. MTR-A2756G genotyping was performed by PCR-RFLP technique...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724261/development-of-a-sandwich-enzyme-linked-immunosorbent-assay-for-dtmp-gh-fusion-protein-by-rational-immunogen-selection
#2
Song Wang, Mingqiang Shen, Shilei Chen, Cheng Wang, Fang Chen, Mo Chen, Gaomei Zhao, Xinze Ran, Tianmin Cheng, Yongping Su, Yang Xu, Junping Wang
dTMP-GH is a chimeric protein containing a tandem dimer of thrombopoietin mimetic peptide (dTMP) fused to human growth hormone (hGH) prepared previously by our team. It shows significant bioactivity in promoting thrombocytopoiesis, but detection of intact dTMP-GH in plasma is still a challenge due to the presence of endogenous hGH. In this study, a rabbit polyclonal antibody with high affinity to dTMP was obtained with a BSA-conjugated immunogen composed of 20 amino acids sequence spanning two TMP and the linker...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28724258/lldt-288-a-novel-triptolide-analogue-exhibits-potent-antitumor-activity-in-vitro-and-in-vivo
#3
Hongtao Xu, Xiaoting Fan, Guanjun Zhang, Xiaoyu Liu, Zhihong Li, Yuanchao Li, Biao Jiang
(14S)-14β-(1-(2-morpholinoethyl)-1H-indazol-5-ylamino)mthylepitriptolide (LLDT-288) was a novel C14β-heterocycle aminomethyl substituent triptolide analogue, which showed comparable cytotoxicity to triptolide. Here we demonstrated that LLDT-288 displayed broad-spectrum, potent antitumor activity, effectively against drug-resistance cancer cells, and induced apoptosis in vitro, but exerted low toxicity. Moreover, it exhibited a remarkable microsomal stability, and showed no inhibitory effects on different cytochrome P450 isoforms...
July 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724248/exposure-to-particulate-air-pollution-during-early-pregnancy-is-associated-with-placental-dna-methylation
#4
Jing Cai, Yan Zhao, Pengcheng Liu, Bin Xia, Qingyang Zhu, Xiu Wang, Qi Song, Haidong Kan, Yunhui Zhang
Maternal exposure to particulate matter with aerodynamic diameter <10μm (PM10) during pregnancy results in adverse birth outcomes. Changes in placental DNA methylation might mediate those adverse effects. In this study, we examined the associations between prenatal PM10 exposure and DNA methylation of LINE1, HSD11B2 and NR3C1 in human placenta. One hundred and eighty-one mother newborn pairs (80 fetal growth restriction newborns, 101 normal newborns) participated in this study. The average PM10 exposure of each trimester and of the whole pregnancy was calculated using daily air pollution concentration data...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724247/persistent-organic-pollutants-and-risk-of-diabetes-and-obesity-on-healthy-adults-results-from-a-cross-sectional-study-in-spain
#5
Luis Alberto Henríquez-Hernández, Octavio P Luzardo, Pilar F Valerón, Manuel Zumbado, Lluis Serra-Majem, María Camacho, Ana González-Antuña, Luis D Boada
Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), and it has been recently reported that environmental chemical contamination could play a role in the development of this disease. We performed a cross-sectional study in a representative sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as risk factors for diabetes in this population...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724246/health-consequences-of-electric-lighting-practices-in-the-modern-world-a-report-on-the-national-toxicology-program-s-workshop-on-shift-work-at-night-artificial-light-at-night-and-circadian-disruption
#6
REVIEW
Ruth M Lunn, David E Blask, Andrew N Coogan, Mariana G Figueiro, Michael R Gorman, Janet E Hall, Johnni Hansen, Randy J Nelson, Satchidananda Panda, Michael H Smolensky, Richard G Stevens, Fred W Turek, Roel Vermeulen, Tania Carreón, Claire C Caruso, Christina C Lawson, Kristina A Thayer, Michael J Twery, Andrew D Ewens, Sanford C Garner, Pamela J Schwingl, Windy A Boyd
The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724245/radioactively-hot-particles-detected-in-dusts-and-soils-from-northern-japan-by-combination-of-gamma-spectrometry-autoradiography-and-sem-eds-analysis-and-implications-in-radiation-risk-assessment
#7
Marco Kaltofen, Arnie Gundersen
After the March 11, 2011, nuclear reactor meltdowns at Fukushima Dai-ichi, 180 samples of Japanese particulate matter (dusts and surface soils) and 235 similar U.S. and Canadian samples were collected and analyzed sequentially by gamma spectrometry, autoradiography, and scanning electron microscopy with energy dispersive X-ray analysis. Samples were collected and analyzed over a five-year period, from 2011 to 2016. Detectable levels of (134)Cs and (137)Cs were found in 142 of 180 (80%) Japanese particulate matter samples...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724243/extensively-and-multi-drug-resistant-acinetobacter-baumannii-recovered-from-technosol-at-a-dump-site-in-croatia
#8
Jasna Hrenovic, Goran Durn, Martina Seruga Music, Svjetlana Dekic, Tamara Troskot-Corbic, Dijana Skoric
In a karst pit above City of Rijeka in Croatia the hazardous industrial waste was continuously disposed from 1955 to 1990, and later it was periodically used as an illegal dump site. The surface part of a technosol at the edge of dump was analysed mineralogically, geochemically and bacteriologically. From the technosol rich in petroleum hydrocarbons and heavy metals three isolates of Acinetobacter baumannii were recovered. Isolates from technosol shared many features that are previously described for clinically isolates: the affiliation to IC1 and 2, multi-drug resistant (MDR) or extensively drug-resistant (XDR) antibiotic resistance profile, carbapenem resistance mediated by blaOXA72 and blaOXA23 genes, and the expression of virulence factors...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724224/assessing-natural-and-anthropogenic-influences-on-water-discharge-and-sediment-load-in-the-yangtze-river-china
#9
Yifei Zhao, Xinqing Zou, Qing Liu, Yulong Yao, Yali Li, Xiaowei Wu, Chenglong Wang, Wenwen Yu, Teng Wang
The water discharge and sediment load of rivers are changing substantially under the impacts of climate change and human activities, becoming a hot issue in hydro-environmental research. In this study, the water discharge and sediment load in the mainstream and seven tributaries of the Yangtze River were investigated by using long-term hydro-meteorological data from 1953 to 2013. The non-parametric Mann-Kendall test and double mass curve (DMC) were used to detect trends and abrupt change-points in water discharge and sediment load and to quantify the effects of climate change and human activities on water discharge and sediment load...
July 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724215/melatonin-inhibits-proliferation-and-invasion-via-repression-of-mirna-155-in-glioma-cells
#10
Junyi Gu, Zhongsheng Lu, Chenghong Ji, Yuchao Chen, Yuzhao Liu, Zhe Lei, Longqiang Wang, Hong-Tao Zhang, Xiangdong Li
Melatonin, an indolamine mostly synthesized in the pineal gland, exerts the anti-cancer effect by various mechanisms in glioma cells. Our previous study showed that miR-155 promoted glioma cell proliferation and invasion. However, the question of whether melatonin may inhibit glioma by regulating miRNAs has not yet been addressed. In this study, we found that melatonin (100μM, 1μM and 1nM) significantly inhibited the expression of miR-155 in human glioma cell lines U87, U373 and U251. Especially, the lowest expression of miR-155 was detected in 1μM melatonin-treated glioma cells...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724213/characterization-of-serum-estradiol-level-and-tissue-estrogen-receptor-immunostaining-with-clinical-response-and-reproductive-factor-changes-in-chinese-female-patients-with-esophageal-squamous-cell-carcinoma
#11
Dongyun Zhang, Jianwei Ku, Ran Liu, Hongfang Wu, Guina Liang, Yan Wei, Peinan Chen, Xueke Zhao, Song Liu, Yin Li, Jianchao Yao, Xin Song, Lidong Wang
Pre-menopausal female patients have a prolonged survival than post-menopausal patients, indicating that estrogen and/or estrogen receptor (ER) may have some biological effects on prognosis. ER expression in cancer tissue has been reported to be a significant prognostic marker in multiple human cancers. However, the prognostic value of estrogen and/or ER on female patients with esophageal squamous cell carcinoma (ESCC) is rarely reported. The present study was undertaken to elucidate the associations of serum estradiol level, tissue estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) expression with clinical response and reproductive factor changes in 387 female ESCC patients...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724210/dandelion-root-extract-suppressed-gastric-cancer-cells-proliferation-and-migration-through-targeting-lncrna-ccat1
#12
Huanhuan Zhu, Hangyong Zhao, Linjie Zhang, Jianmin Xu, Chunhua Zhu, Hui Zhao, Guoqiang Lv
Gastric cancer (GC) is one of the most common tumors worldwide. Standard treatment after early detection involves surgical excision (recurrence is possible), and metastatic gastric cancer is refractory to immuno-, radio-, and most harmful chemotherapies. Various natural compounds have shown efficacy in killing different cancers, albeit not always specifically. In this study, we show that dandelion root extract (DRE) specifically and effectively suppresses proliferation and migration in human gastric cells without inducing toxicity in noncancerous cells...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724201/variations-in-the-bioactive-compounds-composition-and-biological-activities-of-loofah-luffa-cylindrica-fruits-in-relation-to-maturation-stages
#13
Takoua Ben Hlel, Feten Belhadj, Fatih Gül, Muhammed Altun, Ayşe ŞahinYağlıoğlu, Ibrahim Demirtaş, M Nejib Marzouki
The present work aimed to determine the antioxidant and antiproliferative potential of Luffa cylindrica fruits collected at two different maturation stages and to identify and compare their functional components composition. The methanolic extracts of L. cylindrica fruits harvested at 60 to 65 days after seeding (S1) and 85 to 90 days after seeding (S2) were investigated for their antioxidant activity using various assays. Furthermore, the antiproliferative activity of the extracts against HeLa human cervical cancer cells was explored with xCELLigence real time cell analyzer while the effect of the samples on the membrane integrity of the same cell line was assessed using LDH cytotoxicity leakage assay...
July 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28724179/contribution-of-electron-microscopy-to-study-in-vitro-inositol-effects-on-human-spermatozoa
#14
M Colone, A Calcabrini, V Unfer, A Stringaro
Infertility is a worldwide problem and male partner contributes to almost 30% of cases of infertility. The term oligoasthenoteratospermia is related to defective spermatogenesis and is characterized by a reduction of motility and number of spermatozoa and a change in their morphology. Electron microscopes are frequently used in order to evaluate sperm pathology and overall to establish a correlation between structural and functional deficiencies of altered sperm. High levels of reactive oxygen species endanger sperm function and viability...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28724165/cytogenotoxicity-of-inclusion-complexes-of-diazepam-with-2-hydroxypropyl-%C3%AE-cyclodextrin
#15
Jasmina Hadžiabdić, Nevenka Kopjar, Davor Želježić, Selma Špirtović-Halilović, Davorka Završnik
Background Diazepam, as one of the most frequent prescribed drug from 1,4-benzodiazepine group, has certain limitations in pharmaceutical technology due to its poor solubility in water. By forming inclusion complexes with 2-hydroxypropyl-β-cyclodextrin, diazepam's biopharmaceutical properties can be greatly improved. Aim Aim of this research was to in vitro evaluate genotoxicity of prepared novel complexes of diazepam and their influence on proliferation of human peripheral blood lymphocytes. Methods For identification of possible genotoxicity of diazepam inclusion complexes, cytokinesis-block micronucleus assay has been chosen...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28724164/predictive-characteristics-of-elevated-1-hour-glucose-challenge-test-results-for-gestational-diabetes
#16
Alan T N Tita, Yinglei Lai, Mark B Landon, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, John M Thorp, Anthony Sciscione, Patrick Catalano, Margaret Harper, George R Saade, Steve N Caritis, Yoram Sorokin, Alan M Peaceman, Jorge E Tolosa
No abstract text is available yet for this article.
July 19, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28724105/nitrifying-kinetics-and-the-persistence-of-nitrite-in-the-seine-river-france
#17
M Raimonet, T Cazier, V Rocher, A M Laverman
Although a higher oxidation rate for nitrite than for ammonia generally prevents nitrite accumulation in oxic waters, nitrite concentrations in the Seine River (1-31 μM) exceed European norms. We investigated the kinetics of in situ ammonia- and nitrite-oxidizing communities in river water and wastewater treatment plant (WWTP) effluents to determine the role of pelagic nitrification in the origin and persistence of nitrite downstream of Paris. The main source of nitrite is the major Parisian WWTP, and its persistence, up to tens of kilometers downstream of the plant, is explained by low ammonia and nitrite oxidation rates and high river flow...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724093/persistence-of-ascaris-spp-ova-in-tropical-soil-cultivated-with-eucalyptus-and-fertilized-with-municipal-biosolids
#18
Marianne F de Faria, Iraê A Guerrini, Fernando C Oliveira, Maria Inês Z Sato, Elayse M Hachich, José Raimundo S Passos, Lívia M L Goulart, Thiago T de S Silva, José L Gava, Joel C Furches, Jason James, Robert B Harrison
In many countries, the main reason for severely restricting or outright banning the land application of class B biosolids is the lack of risk assessment for adverse human health impacts. Among pathogens that are not often studied are helminth ova, including that of the spp. Almost all of the knowledge about the persistence of spp. ova in soils fertilized with biosolids is based on studies developed in North America, Europe, and Asia. These studies have almost always been conducted under temperate climate conditions, which may cause erroneous interpretations when the conclusions are extrapolated to tropical regions such as those found in Brazil...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724070/marker-trait-association-analysis-of-iron-and-zinc-concentration-in-lentil-lens-culinaris-medik-seeds
#19
Hamid Khazaei, Rajib Podder, Carolyn T Caron, Shudhangshu S Kundu, Marwan Diapari, Albert Vandenberg, Kirstin E Bett
Lentil ( Medik.) seeds are relatively rich in iron (Fe) and zinc (Zn), making lentil a potential crop to aid in the global battle against human micronutrient deficiency. Understanding the genetic basis for uptake of seed Fe and Zn is required to increase sustainable concentrations of these minerals in seeds. The objectives of this study were to characterize genetic variation in seed Fe and Zn concentration and to identify molecular markers associated with these traits across diverse lentil accessions. A set of 138 cultivated lentil accessions from 34 countries were evaluated in four environments (2 sites × 2 yr) in Saskatchewan, Canada...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724043/compulsory-notification-at-skilled-nursing-facilities
#20
Milton Luiz Gorzoni, Márcia Regina Valadares Aguado, Sueli Luciano Pires, Lilian de Fátima Costa Faria
Introduction: Notifiable diseases (NDs) encompass conditions of high clinical severity and/or contagious. Being closed communities, long-term care facilities (LTCF) are places that deserve attention on their own, but one might be left wondering: what is the reality of NDs at Brazilian LTCFs? Objective: To determine the prevalence and type of NDs at large LTCF. Method: Active search for NDs conducted by the Hospital Infection Control Committee (HICC) in 459 beds...
May 2017: Revista da Associação Médica Brasileira
keyword
keyword
16880
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"