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https://www.readbyqxmd.com/read/28199805/bariatric-surgery-versus-intensive-medical-therapy-for-diabetes-5-year-outcomes
#1
Philip R Schauer, Deepak L Bhatt, John P Kirwan, Kathy Wolski, Ali Aminian, Stacy A Brethauer, Sankar D Navaneethan, Rishi P Singh, Claire E Pothier, Steven E Nissen, Sangeeta R Kashyap
Background Long-term results from randomized, controlled trials that compare medical therapy with surgical therapy in patients with type 2 diabetes are limited. Methods We assessed outcomes 5 years after 150 patients who had type 2 diabetes and a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 27 to 43 were randomly assigned to receive intensive medical therapy alone or intensive medical therapy plus Roux-en-Y gastric bypass or sleeve gastrectomy. The primary outcome was a glycated hemoglobin level of 6...
16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28192226/use-of-preventive-medication-in-patients-with-limited-life-expectancy-a-systematic-review
#2
REVIEW
Arjun Poudel, Patsy Yates, Debra Rowett, Lisa M Nissen
CONTEXT: Optimal prescribing in patients with limited life expectancy remains unclear. OBJECTIVES: This study systematically reviews the published literature regarding the use of preventive medication in patients with reduced life expectancy. METHODS: A systematic literature search was conducted using three databases (MEDLINE, EMBASE and CINAHL). Articles published in English from January 1995 to December 2015 were retrieved for analysis to identify peer-reviewed, observational studies assessing use of preventive medications in patients with limited life expectancy...
February 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28185711/impact-of-gastroesophageal-reflux-and-delayed-gastric-emptying-on-pediatric-lung-transplant-outcomes
#3
Fei Jamie Dy, Dawn Freiberger, Enju Liu, Debra Boyer, Gary Visner, Rachel Rosen
BACKGROUND: Gastroesophageal reflux disease is thought to predispose to adverse lung allograft outcomes. However, little is known about the burden of gastroesophageal reflux (GER) and gastroparesis in pediatric patients. In this study we describe the burden of reflux and gastroparesis in children undergoing lung transplant, and evaluates their impact on allograft survival and rejection incidence. METHODS: This study is a retrospective analysis of pediatric lung transplant recipients who had combined pH and multichannel intraluminal impedance testing (pH-MII) and gastric-emptying scans (GES)...
January 6, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28175217/p682-risk-factors-and-clinical-outcome-in-ibd-patients-with-melanoma
#4
L H Nissen, M Pierik, L A A P Derikx, E de Jong, W Kievit, T van den Heuvel, A van Rosendael, E Plasmeijer, P Dewint, I D Nagtegaal, F Hoentjen, A van der Meulen
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167676/doping-and-drug-testing-anti-doping-work-must-be-transparent-and-adhere-to-good-scientific-practices-to-ensure-public-trust
#5
Erik Boye, Tore Skotland, Bjarne Østerud, Jon Nissen-Meyer
No abstract text is available yet for this article.
February 6, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28166998/isolated-tracheoesophageal-fistula-versus-esophageal-atresia-early-morbidity-and-short-term-outcome-a-single-institution-series
#6
R B Tröbs, W Finke, M Bahr, C Roll, M Nissen, M R Vahdad, G Cernaianu
PURPOSE: We compared the postnatal course, morbidity and early results after repair for cases of isolated or "pure" TEF with those for cases of esophageal atresia (EA) with distal tracheoesophageal fistula (TEF). METHODS: Twenty-four consecutive infants were divided into two groups: isolated TEF [TEF group] (n = 5) and EA with distal TEF [EA group] (n = 19). RESULTS: A high rate of prematurity (29%) and major cardiac and other surgically-relevant malformations (0...
March 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28164012/effect-of-serial-infusions-of-reconstituted-high-density-lipoprotein-cer-001-on-coronary-atherosclerosis-rationale-and-design-of-the-carat-study
#7
Jordan Andrews, Alex Janssan, Tracy Nguyen, Anthony D Pisaniello, Daniel J Scherer, John J P Kastelein, Bela Merkely, Steven E Nissen, Kausik Ray, Gregory G Schwartz, Stephen G Worthley, Connie Keyserling, Jean-Louis Dasseux, Julie Butters, Jacinta Girardi, Rosemary Miller, Stephen J Nicholls
BACKGROUND: High-density lipoprotein (HDL) is believed to have atheroprotective properties, but an effective HDL-based therapy remains elusive. Early studies have suggested that infusion of reconstituted HDL promotes reverse cholesterol transport and vascular reactivity. The CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial (CARAT) is investigating the impact of infusing an engineered pre-beta HDL mimetic containing sphingomyelin (SM) and dipalmitoyl phosphatidlyglycerol (CER-001) on coronary atheroma volume in patients with a recent acute coronary syndrome (ACS)...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28158901/long-term-symptom-control-of-gastro-oesophageal-reflux-disease-12-years-after-laparoscopic-nissen-or-180%C3%A2-anterior-partial-fundoplication-in-a-randomized-clinical-trial
#8
D J Roks, J A Broeders, R J Baigrie
BACKGROUND: Laparoscopic 180° anterior fundoplication has been shown to achieve similar reflux control to Nissen fundoplication, with fewer side-effects, up to 5 years. However, there is a paucity of long-term follow-up data on this technique and antireflux surgery in general. This study reports 12-year outcomes of a double-blind RCT comparing laparoscopic Nissen versus 180° laparoscopic anterior fundoplication for gastro-oesophageal reflux disease (GORD). METHODS: Patients with proven GORD were randomized to laparoscopic Nissen or 180° anterior fundoplication...
February 3, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28157835/bacillus-calmette-gu%C3%A3-rin-vaccination-thymic-size-and-thymic-output-in-healthy-newborns
#9
Nina Marie Birk, Thomas Nørrelykke Nissen, Vera Zingmark, Jesper Kjærgaard, Lisbeth Marianne Thøstesen, Poul-Erik Kofoed, Lone Graff Stensballe, Andreas Andersen, Susanne Dam Nielsen, Christine Stabell Benn, Ole Pryds, Dorthe Lisbeth Jeppesen
BACKGROUND: The Bacillus Calmette-Guérin vaccine (BCG) has been associated with beneficial nonspecific effects on infant health. We aimed to examine the effect of BCG at birth on thymic size and the associations between thymic output, circulating lymphocytes, risk of infection, and thymic size. METHODS: In infants randomized to BCG or no BCG, thymic index (TI), and thymic/weight index (TWI) were measured by ultrasound at birth and at the age of 3 months. T cell subpopulations including CD4(+) T cells, CD8(+) T cells, and recent thymic emigrants (RTEs) were assessed by flow cytometry...
February 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28155231/charge-syndrome-gastrointestinal-involvement-from-mouth-to-anus
#10
REVIEW
A Hudson, M Macdonald, J N Friedman, K Blake
CHARGE syndrome is an autosomal dominant disorder that occurs as a result of a heterozygous loss-of-function mutation in the chromodomain helicase DNA-binding (CHD7) gene, which is important for neural crest cell formation. Gastrointestinal (GI) symptoms and feeding difficulties are highly prevalent but are often a neglected area of diagnosis, treatment, and research. Cranial nerve dysfunction, craniofacial abnormalities, and other physical manifestations of this syndrome lead to gut dysmotility, sensory impairment, and oral-motor function abnormalities...
October 13, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/28153861/patient-reported-outcomes-in-patients-undergoing-arthroscopic-partial-meniscectomy-for-traumatic-or-degenerative-meniscal-tears-comparative-prospective-cohort-study
#11
Jonas Bloch Thorlund, Martin Englund, Robin Christensen, Nis Nissen, Kenneth Pihl, Uffe Jørgensen, Jeppe Schjerning, L Stefan Lohmander
OBJECTIVES:  To compare patient reported outcomes from before surgery to 52 weeks after surgery between individuals undergoing arthroscopic partial meniscectomy for traumatic meniscal tears and those for degenerative meniscal tears. DESIGN:  Comparative prospective cohort study. SETTING:  Four public orthopaedic departments in the Region of Southern Denmark. Participants were recruited between 1 February 2013 and 31 January 2014, and at one of the original four hospitals from 1 February 2014 to 31 January 2015...
February 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28145965/laparoscopic-anterior-partial-fundoplication-is-comparable-with-nissen-fundoplication-for-gastroesophageal-reflux-disease
#12
Pawanindra Lal, Swati H Shah, Nitin Leekha, Amarender Singh Puri
BACKGROUND: Laparoscopic Nissen fundoplication (LNF) has been the gold standard for gastroesophageal reflux disease (GERD), but the side effects of dysphagia and bloating have lead to interest in partial fundoplication as an alternative. AIM: To compare the symptomatic and objective parameters after LNF and laparoscopic anterior partial fundoplication (LAPF) in patients with GERD. PATIENTS AND METHODS: The study was conducted in the Division of Minimal Access Surgery, Maulana Azad Medical College from June 2008 to October 2016...
February 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28118788/3d-vision-provides-shorter-operative-time-and-more-accurate-intraoperative-surgical-performance-in-laparoscopic-hiatal-hernia-repair-compared-with-2d-vision
#13
Piera Leon, Roberta Rivellini, Fabiola Giudici, Antonio Sciuto, Felice Pirozzi, Francesco Corcione
BACKGROUND: The aim of this study is to evaluate if 3-dimensional high-definition (3D) vision in laparoscopy can prompt advantages over conventional 2D high-definition vision in hiatal hernia (HH) repair. STUDY DESIGN: Between September 2012 and September 2015, we randomized 36 patients affected by symptomatic HH to undergo surgery; 17 patients underwent 2D laparoscopic HH repair, whereas 19 patients underwent the same operation in 3D vision. RESULTS: No conversion to open surgery occurred...
January 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28115899/a-systematic-approach-to-the-comparison-of-cost-efficiency-of-endopeptidases-for-the-hydrolysis-of-atlantic-salmon-salmo-salar-by-products
#14
Tone Aspevik, Henning Egede-Nissen, Ĺge Oterhals
The hydrolytic and cost efficiencies of five endopeptidases (Alcalase 2.4L, Corolase 7089, Neutrase 0.8L, Promod 671L and Protex 7L) to hydrolyze Atlantic salmon by-products were compared at standardized activity levels based on a casein assay. The substrate was characterized prior to the hydrolytic experiments (pH=6.5, t=50 °C) to obtain substrate--specific constants for nitrogen to protein mass (in g) ratio, i.e. conversion factor fN=5.23 and total amount of peptide bonds (htot)=9.3 mmol per g of protein...
December 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28112500/methodological-quality-completeness-of-reporting-and-use-of-systematic-reviews-as-evidence-in-clinical-practice-guidelines-for-paediatric-overweight-and-obesity
#15
T Nissen, C Wayant, A Wahlstrom, P Sinnett, C Fugate, J Herrington, M Vassar
Paediatric obesity rates remain high despite extensive efforts to prevent and treat obesity in children. We investigated the quality of the methodology and reporting within systematic reviews (SRs) underpinning paediatric content in US clinical practice guidelines (CPGs). In June 2016 we searched guideline clearinghouses and professional organization websites for guidelines published by national or professional organizations in the United States from January 2007 onwards. In our primary, a priori analysis, we used PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and AMSTAR (A Measurement Tool to Assess Systematic Reviews) instruments to score SRs and meta-analyses that included paediatric populations and were cited by included CPGs...
February 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28110385/the-prevalence-of-anticitrullinated-protein-antibodies-increases-with-age-in-healthy-individuals-at-risk-for-rheumatoid-arthritis
#16
D Alpizar-Rodriguez, Laure Brulhart, Ruediger B Mueller, Burkhard Möller, Jean Dudler, Adrian Ciurea, Ulrich A Walker, Ines Von Mühlenen, Diego Kyburz, Pascal Zufferey, Michael Mahler, Sylvette Bas, Danielle Gascon, Céline Lamacchia, Pascale Roux-Lombard, Kim Lauper, Michael J Nissen, Delphine S Courvoisier, Cem Gabay, Axel Finckh
Transition from genetic risk to the development of systemic autoimmunity associated with rheumatoid arthritis (RA) is considered a key step for the development of RA and often referred to as the immune onset of the disease. The aim of this study is to identify predictors for the presence of anticitrullinated protein antibodies (ACPA) as a marker of systemic autoimmunity associated with RA in a high-risk population, an ongoing cohort of first-degree relatives of patients with RA. We assessed the presence of ACPA in individuals without clinical evidence of RA...
January 21, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28107284/postsurgical-perforation-of-the-esophagus-can-be-treated-using-a-fully-covered-stent-in-children
#17
Chantal Chauvet, Arnaud Bonnard, Alexis Mosca, Marc Bellaïche, Pascale Philippe-Chomette, Jérôme Viala
OBJECTIVES: Surgery and conservative treatment of esophageal or gastric perforations are both often associated with poor results and carry a high morbidity and mortality rate. The aim of the present study was to evaluate the effectiveness and safety of using fully covered self-expending metallic stents (SEMS) in children with upper digestive leaks. METHODS: This retrospective study reviewed all children with esophageal or gastric perforation who were treated with placement of an SEMS from January 2011 to January 2015...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28106005/modification-of-the-saturation-magnetization-of-exchange-bias-thin-film-systems-upon-light-ion-bombardment
#18
Henning Huckfeldt, Alexander Gaul, Nicolas David Müglich, Dennis Holzinger, Dennis Nissen, Manfred Albrecht, Daniel Emmrich, André Beyer, Armin Gölzhäuser, Arno Ehresmann
The magnetic modification of exchange bias materials by 'ion bombardment induced magnetic patterning' has been established more than a decade ago. To understand these experimental findings several theoretical models were introduced. Few investigations, however, did focus on magnetic property modifications caused by effects of ion bombardment in the ferromagnetic layer. In the present study, the structural changes occurring under ion bombardment were investigated by Monte-Carlo simulations and in experiments...
March 29, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28095117/parents-asthma-information-needs-and-preferences-for-school-based-asthma-support
#19
Noha Abdullah Al Aloola, Lisa Nissen, Huda Abdullaziz Alewairdhi, Nawaf Al Faryan, Bandana Saini
Objectives This study sought to investigate parents' needs and preferences for school-based asthma support in Saudi Arabian primary schools. Methods Semi-structured qualitative interviews were conducted in the period between November 2015 and February 2016, with a convenience sample that comprised Saudi parents and carers of children with asthma. Recruitment of participants was primarily driven through Saudi primary schools; passive snowballing and social networks were used to boost participation rates further...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28093604/pretreatment-with-5-fluorouracil-cream-enhances-the-efficacy-of-daylight-mediated-photodynamic-therapy-for-actinic-keratosis
#20
Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans C Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone...
January 17, 2017: Acta Dermato-venereologica
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