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https://www.readbyqxmd.com/read/28320858/the-role-of-tm5-in-na2-release-and-the-conformational-transition-of-neurotransmitter-sodium-symporters-toward-the-inward-open-state
#1
Sebastian Stolzenberg, Zheng Li, Matthias Quick, Lina Malinauskaite, Poul Nissen, Harel Weinstein, Jonathan A Javitch, Lei Shi
Neurotransmitter:sodium symporters (NSS) terminate neurotransmission by the reuptake of released neurotransmitters. This active accumulation of substrate against its concentration gradient is driven by the transmembrane Na+ gradient and requires that the transporter traverses several conformational states. LeuT, a prokaryotic NSS homolog, has been crystallized in outward-open, outward-occluded and inward-open states. Two crystal structures of another prokaryotic NSS homolog, the multi-hydrophobic amino acid transporter (MhsT) from Bacillus halodurans have been resolved in novel inward-occluded states, with the extracellular vestibule closed and the intracellular portion of TM5 (TM5i) in either an unwound or a helical conformation...
March 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28318766/bacille-calmette-gu%C3%A3-rin-bcg-vaccination-at-birth-and-antibody-responses-to-childhood-vaccines-a-randomised-clinical-trial
#2
Thomas Nørrelykke Nissen, Nina Marie Birk, Gaby Smits, Dorthe Lisbeth Jeppesen, Lone Graff Stensballe, Mihai G Netea, Fiona van der Klis, Christine Stabell Benn, Ole Pryds
INTRODUCTION: BCG vaccination has been associated with beneficial non-specific effects on child health. Some immunological studies have reported heterologous effects of vaccines on antibody responses to heterologous vaccines. Within a randomised clinical trial of Bacille Calmette-Guérin (BCG) vaccination at birth, The Danish Calmette Study, we investigated the effect of BCG at birth on the antibody response to the three routine vaccines against DiTeKiPol/Act-Hib and Prevenar 13 in a subgroup of participants...
March 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28317316/severely-impaired-gastric-accommodation-is-a-hallmark-of-post-nissen-functional-dyspepsia-symptoms
#3
A Pauwels, V Boecxstaens, C Broers, J F Tack
BACKGROUND: Laparoscopic Nissen fundoplication is a commonly performed antireflux surgery, after which reflux symptoms are well controlled, however, complications such as inability to belch or dyspeptic symptoms (mimicking those of functional dyspepsia [FD]) might occur. The aim of the study was to prospectively evaluate symptom pattern and underlying pathophysiological mechanisms in patients with post-Nissen dyspepsia. METHODS: Twenty-four patients (12 f, mean age 44...
March 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28304242/cardiovascular-efficacy-and-safety-of-bococizumab-in-high-risk-patients
#4
Paul M Ridker, James Revkin, Pierre Amarenco, Robert Brunell, Madelyn Curto, Fernando Civeira, Marcus Flather, Robert J Glynn, Jean Gregoire, J Wouter Jukema, Yuri Karpov, John J P Kastelein, Wolfgang Koenig, Alberto Lorenzatti, Pravin Manga, Urszula Masiukiewicz, Michael Miller, Arend Mosterd, Jan Murin, Jose C Nicolau, Steven Nissen, Piotr Ponikowski, Raul D Santos, Pamela F Schwartz, Handrean Soran, Harvey White, R Scott Wright, Michal Vrablik, Carla Yunis, Charles L Shear, Jean-Claude Tardif
Background Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. Methods In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo...
March 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28304227/lipid-reduction-variability-and-antidrug-antibody-formation-with-bococizumab
#5
Paul M Ridker, Jean-Claude Tardif, Pierre Amarenco, William Duggan, Robert J Glynn, J Wouter Jukema, John J P Kastelein, Albert M Kim, Wolfgang Koenig, Steven Nissen, James Revkin, Lynda M Rose, Raul D Santos, Pamela F Schwartz, Charles L Shear, Carla Yunis
Background Bococizumab, a humanized monoclonal antibody targeting proprotein convertase subtilisin-kexin type 9 (PCSK9), reduces levels of low-density lipoprotein (LDL) cholesterol. However, the variability and durability of this effect are uncertain. Methods We conducted six parallel, multinational lipid-lowering trials enrolling 4300 patients with hyperlipidemia who were randomly assigned to receive 150 mg of bococizumab or placebo subcutaneously every 2 weeks and who were followed for up to 12 months; 96% were receiving statin therapy at the time of enrollment...
March 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28302728/a-high-and-phosphatidylinositol-4-phosphate-pi4p-dependent-atpase-activity-for-the-drs2p-cdc50p-flippase-after-removal-of-its-n-and-c-terminal-extensions
#6
Hassina Azouaoui, Cédric Montigny, Thibaud Dieudonné, Philippe Champeil, Aurore Jacquot, José Luis Vázquez-Ibar, Pierre Le Maréchal, Jakob Ulstrup, Miriam-Rose Ash, Joseph A Lyons, Poul Nissen, Guillaume Lenoir
P4-ATPases, also known as phospholipid flippases, are responsible for creating and maintaining transbilayer lipid asymmetry in eukaryotic cell membranes. Here, we use limited proteolysis to investigate the role of the N- and C-termini in ATP hydrolysis and auto-inhibition of the yeast flippase Drs2p/Cdc50p. We show that limited proteolysis of the detergent-solubilized and purified yeast flippase may result in more than one order of magnitude increase of its ATPase activity, which remains dependent on phosphatidylinositol-4-phosphate (PI4P), a regulator of this lipid flippase, and specific to a phosphatidylserine substrate...
March 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28302291/statin-intolerance-an-elusive-but-morbid-disorder
#7
EDITORIAL
Steven E Nissen
No abstract text is available yet for this article.
March 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28295217/randomized-clinical-trial-of-270%C3%A2-posterior-versus-180%C3%A2-anterior-partial-laparoscopic-fundoplication-for-gastro-oesophageal-reflux-disease
#8
D J Roks, J H Koetje, J E Oor, J A Broeders, V B Nieuwenhuijs, E J Hazebroek
BACKGROUND: Partial fundoplications provide similar reflux control with fewer post-fundoplication symptoms compared with Nissen fundoplication for gastro-oesophageal reflux disease (GORD). The best choice of procedure for partial fundoplication remains unclear. The aim of this study was to compare the outcome of two different types of partial fundoplication for GORD. METHODS: A double-blind RCT was conducted between 2012 and 2015 in two hospitals specializing in antireflux surgery...
March 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28294958/seventeen-year-outcome-of-a-randomized-clinical-trial-comparing-laparoscopic-and-conventional-nissen-fundoplication-a-plea-for-patient-counseling-and-clarification
#9
Jelmer E Oor, David J Roks, Joris A Broeders, Eric J Hazebroek, Hein G Gooszen
OBJECTIVE: To analyze long-term outcome of a randomized clinical trial comparing laparoscopic Nissen fundoplication (LNF) and conventional Nissen fundoplication (CNF) for the treatment of gastroesophageal reflux disease (GERD). BACKGROUND: LNF has replaced CNF, based on positive short and mid-term outcome. Studies with a follow-up of over 15 years are scarce, but are desperately needed for patient counselling. METHODS: Between 1997 and 1999, 177 patients with proton pump inhibitor (PPI)-refractory GERD were randomized to CNF or LNF...
December 6, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28290942/increased-postdeployment-use-of-medication-for-common-mental-disorders-in-danish-gulf-war-veterans
#10
Lars Ravnborg Nissen, Christian Stoltenberg, Mia Sadowa Vedtofte, Anni Brit Sternhagen Nielsen, Jacob Louis Marott, Finn Gyntelberg, Bernadette Guldager
BACKGROUND: Gulf War veterans (GWVs) have an elevated risk of reporting symptoms of mental disorders as compared with nondeployed military controls. A difficulty in the Gulf War health research is that most health outcomes are self-reported; therefore, it is highly relevant to study objective outcomes in this line of research. The Danish National Prescription Registry provides an opportunity to use the prescription of drugs as an objective evaluation of the impact of mental health disorders at the individual level...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28280617/identifying-prognostic-intratumor-heterogeneity-using-pre-and-post-radiotherapy-18f-fdg-pet-images-for-pancreatic-cancer-patients
#11
Yong Yue, Arsen Osipov, Benedick Fraass, Howard Sandler, Xiao Zhang, Nicholas Nissen, Andrew Hendifar, Richard Tuli
BACKGROUND: To stratify risks of pancreatic adenocarcinoma (PA) patients using pre- and post-radiotherapy (RT) PET/CT images, and to assess the prognostic value of texture variations in predicting therapy response of patients. METHODS: Twenty-six PA patients treated with RT from 2011-2013 with pre- and post-treatment 18F-FDG-PET/CT scans were identified. Tumor locoregional texture was calculated using 3D kernel-based approach, and texture variations were identified by fitting discrepancies of texture maps of pre- and post-treatment images...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28279524/two-residues-determine-the-product-profile-of-the-class-ii-diterpene-synthases-tps14-and-tps21-of-tripterygium-wilfordii
#12
Nikolaj L Hansen, Jakob N Nissen, Björn Hamberger
The medicinal plant Tripterygium wilfordii (Celastraceae) contains a pair of class II diterpene synthases (diTPS) of specialized labdane-type metabolism that, despite remarkably close homology, form strikingly different products. TwTPS21 catalyzes bicyclization of the linear C20 precursor geranylgeranyl diphosphate to ent-copal-8-ol diphosphate, while TwTPS14 forms kolavenyl diphosphate. To determine the amino acid signature controlling the functional divergence of the homologues, we modeled their structures based on an existing crystal structure of the Arabidopsis ent-copalyl diphosphate synthase, archetypal of diTPSs in general metabolism of gibberellin phytohormones...
March 6, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28277299/preoperative-liquid-gastric-emptying-rate-does-not-predict-outcome-after-fundoplication
#13
C K Knatten, J G Fjeld, A W Medhus, A H Pripp, T J Fyhn, L Aabakken, H Kjosbakken, B Edwin, R Emblem, K Bjørnland
AIM OF THE STUDY: Preoperative gastric emptying (GE) rate in patients with gastrointestinal reflux disease (GERD) was evaluated as a predictor of outcome after antireflux surgery. METHODS AND PATIENTS: GE was assessed using radionuclide scintigraphy and a standardized meal with cow's milk. GE half time (T1/2), patient demographics and GERD symptoms including vomiting (>4days/week), retching (>4days/week), prolonged feeding time (>3h/day), and discomfort after meals were recorded pre- and postoperatively...
October 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28273860/microglial-function-across-the-spectrum-of-age-and-gender
#14
REVIEW
Jillian C Nissen
Microglia constitute the resident immunocompetent cells of the central nervous system. Although much work has focused on their ability to mount an inflammatory response in reaction to pathology, recent studies have delved into their role in maintaining homeostasis in the healthy brain. It is important to note that the function of these cells is more complex than originally conceived, as there is increasing evidence that microglial responses can vary greatly among individuals. Here, this review will describe the changing behavior of microglia from development and birth through to the aged brain...
March 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28258450/does-nissen-fundoplication-provide-lifelong-reflux-control-symptomatic-outcome-after-31-33-years
#15
P Neuvonen, J Sand, M Matikainen, T Rantanen
BACKGROUND: A substantial number of people are suffering from gastroesophageal reflux disease (GERD). The indication for surgical treatment is the failure of medical treatment in patients with objectively verified GERD. The use of PPIs has been noted to increase with the length of follow-up after fundoplication, raising questions concerning the durability of surgical results. The aim of the study was to investigate the results of open Nissen fundoplication (ONF) over a follow-up of more than 31 years...
March 3, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28251373/comparison-of-laparoscopic-nissen-and-toupet-fundoplication-using-a-propensity-score-matching-analysis
#16
Masato Hoshino, Nobuo Omura, Fumiaki Yano, Kazuto Tsuboi, Se Ryung Yamamoto, Shunsuke Akimoto, Norio Mitsumori, Hideyuki Kashiwagi, Katsuhiko Yanaga
PURPOSE: Laparoscopic fundoplication (LF) has become a standard operative procedure for GERD-related diseases in Japan, although meta-analyses have mainly evaluated findings from Western countries. The propensity score matching method was used to compare and investigate the treatment outcomes of two fundoplication procedures (the Nissen and Toupet methods). METHODS: Among 474 patients who underwent initial LF from December 1994 to April 2016, we extracted 401 cases (Nissen: 92 cases, Toupet: 309 cases), excluding 73 patients in whom follow-up was insufficient...
March 1, 2017: Surgery Today
https://www.readbyqxmd.com/read/28251188/reproducibility-of-thoracic-kyphosis-measurements-in-patients-with-adolescent-idiopathic-scoliosis
#17
Søren Ohrt-Nissen, Jason Pui Yin Cheung, Dennis Winge Hallager, Martin Gehrchen, Kenny Kwan, Benny Dahl, Kenneth M C Cheung, Dino Samartzis
BACKGROUND: Current surgical treatment for adolescent idiopathic scoliosis (AIS) involves correction in both the coronal and sagittal plane, and thorough assessment of these parameters is essential for evaluation of surgical results. However, various definitions of thoracic kyphosis (TK) have been proposed, and the intra- and inter-rater reproducibility of these measures has not been determined. As such, the purpose of the current study was to determine the intra- and inter-rater reproducibility of several TK measurements used in the assessment of AIS...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28248794/intestinal-metaplasia-of-the-esophagus-in-children-with-esophageal-atresia
#18
Helen Hsieh, Adam Frenette, Laurent Michaud, Usha Krishnan, Dorothée Bouron Dal-Soglio, Frederic Gottrand, Christophe Faure
OBJECTIVES: Patients with esophageal atresia/tracheo-esophageal fistula (EA-TEF) can develop Barrett's esophagus as a long-term consequence of their condition. Intestinal metaplasia (IM), a risk factor for developing adenocarcinoma of the esophagus, has not been well characterized in the pediatric population. METHODS: Retrospective review of EA-TEF patients followed at three academic pediatric centers between the years 1997 and 2014. RESULTS: Among 542 children and adolescents, 1...
February 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28234132/outcome-evaluation-of-laparoscopic-and-open-nissen-fundoplication-in-children-a-systematic-review-and-meta-analysis
#19
REVIEW
Xing Lei, Qingquan Ren, Yang Yang, Tiecheng Bai
Our aim was to estimate the efficacy of laparoscopic and open Nissen fundoplication (ONF) in the treatment of gastroesophageal reflux disease (GERD) in children. An electronic systematic review of the published literature was conducted in Cochrane Library, MEDLINE (PubMed), and EmBase in October 2015 in English and without time restrictions. The participants, interventions, and comparisons in the clinical question translated directly into eligibility criteria for study inclusion and exclusion. Study information extraction and methodological quality assessments were accomplished by two reviewers independently...
January 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28216290/two-years-of-experience-with-robot-assisted-anti-reflux-surgery-a-retrospective-cohort-study
#20
Jonas Sanberg Jensen, Henning Kold Antonsen, Jesper Durup
BACKGROUND AND AIMS: Robot-assisted anti-reflux surgery (RAAS) is an alternative to conventional laparoscopic anti-reflux surgery (CLAS). The purpose of this study was to evaluate initial Danish experiences with robot-assisted anti-reflux surgery compared to conventional laparoscopic anti-reflux surgery incorporating follow-up and evaluation of possible learning curve. MATERIAL AND METHODS: Patients undergoing primary RAAS or CLAS at The Department of Surgery A, Odense University Hospital and The Department of General Surgery, Kolding Hospital from April 2013 to April 2015 was included...
February 13, 2017: International Journal of Surgery
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