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https://www.readbyqxmd.com/read/28088373/dynamic-contrast-enhanced-magnetic-resonance-imaging-dce-mri-for-the-prediction-of-non-union-consolidation
#1
Christian Fischer, Mareike Nissen, Gerhard Schmidmaier, Thomas Bruckner, Hans-Ulrich Kauczor, Marc-André Weber
INTRODUCTION: Non-union perfusion can be visualized with dynamic contrast-enhanced (DCE) MRI. This study evaluated DCE-MRI to predict non-union consolidation after surgery and detect factors that affect bone healing. MATERIALS AND METHODS: Between 2010 and 2015 non-union perfusion was prospectively quantified in 205 patients (mean age, 51.5 years, 129 men, 76 women) before intervention and at 6, 12, 26, 52 and more weeks follow-up. DCE-MRI results were related to the osseous consolidation, the ability to predict successful outcome was estimated by ROC analysis...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28087581/brief-encounters-of-cytochrome-c
#2
Joseph A Lyons, Poul Nissen
No abstract text is available yet for this article.
January 13, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28086849/successful-outcome-following-pneumonectomy-in-a-teenage-boy-with-cystic-fibrosis-a-case-report
#3
Zheyi Liew, Santosh Mallikarjuna, Asif Hasan, F Kate Gould, Su Bunn, Matthew F Thomas, Jim L Lordan, Christopher O'Brien, Malcolm Brodlie
BACKGROUND: Cystic fibrosis lung disease is generally a diffuse process however rarely one lung may become particularly damaged through chronic collapse and consolidation resulting in end-stage bronchiectasis with relative sparing of the contralateral lung. This clinical situation is sometimes referred to as "destroyed lung". Lung resection surgery is seldom indicated in cystic fibrosis and the associated medical literature is relatively sparse. CASE PRESENTATION: A 14 year old boy was referred to our centre for lung transplantation assessment...
January 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28072725/laparoscopic-revision-surgery-for-gastroesophageal-reflux-disease
#4
Haydar Celasin, Volkan Genc, Suleyman Utku Celik, Ahmet Gökhan Turkcapar
Laparoscopic antireflux surgery is a frequently performed procedure for the treatment of gastroesophageal reflux in surgical clinics. Reflux can recur in between 3% and 30% of patients on whom antireflux surgery has been performed, and so revision surgery can be required due to recurrent symptoms or dysphagia in approximately 3% to 6% of the patients. The objective of this study is to evaluate the mechanism of recurrences after antireflux surgery and to share our results after revision surgery in recurrent cases...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28068725/toothpaste-ingestion-in-a-4-year-old-girl-a-bagatelle-incident
#5
Matthias Nissen, Volker Sander, Mohammad Reza Vahdad, René Thränhardt, Ralf-Bodo Tröbs
No abstract text is available yet for this article.
January 9, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28065591/post-fundoplication-symptoms-and-complications-diagnostic-approach-and-treatment
#6
S Sobrino-Cossío, J C Soto-Pérez, E Coss-Adame, G Mateos-Pérez, O Teramoto Matsubara, J Tawil, M Vallejo-Soto, A Sáez-Ríos, J A Vargas-Romero, A M Zárate-Guzmán, E S Galvis-García, M Morales-Arámbula, O Quiroz-Castro, A Carrasco-Rojas, J M Remes-Troche
Laparoscopic Nissen fundoplication is currently considered the surgical treatment of choice for gastroesophageal reflux disease (GERD) and its long-term effectiveness is above 90%. Adequate patient selection and the experience of the surgeon are among the predictive factors of good clinical response. However, there can be new, persistent, and recurrent symptoms after the antireflux procedure in up to 30% of the cases. There are numerous causes, but in general, they are due to one or more anatomic abnormalities and esophageal and gastric function alterations...
January 5, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28058763/relationship-of-glycated-haemoglobin-and-reported-hypoglycaemia-to-cardiovascular-outcomes-in-patients-with-type-2-diabetes-and-recent-acute-coronary-syndromes-the-examine-trial
#7
Simon R Heller, Richard M Bergenstal, William B White, Stuart Kupfer, George L Bakris, William C Cushman, Cyrus R Mehta, Steven E Nissen, Craig A Wilson, Faiez Zannad, Yuyin Liu, Noah M Gourlie, Christopher P Cannon
AIMS: To investigate relationships between glycated haemoglobin (HbA1c) and reported hypoglycaemia and risk of major adverse cardiovascular (CV) events (MACE). METHODS: The EXAMINE trial randomized 5380 patients in 49 countries with type 2 diabetes (T2DM) and a recent acute coronary syndrome (ACS) to double-blind treatment with alogliptin or placebo in addition to standard of care. We used Cox proportional hazards models to analyze relationships among MACE, HbA1c levels and hypoglycaemia events...
January 6, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28058028/hepatosplenic-t-cell-lymphoma-in-a-47-year-old-crohn-s-disease-patient-on-thiopurine-monotherapy
#8
Maartje M van de Meeberg, Lauranne A A P Derikx, Harm A M Sinnige, Peet Nooijen, D Lucette Schipper, Loes H C Nissen
Hepatosplenic T-cell lymphoma (HSTCL) is a rare non-Hodgkin lymphoma with a high mortality rate. Higher incidence is reported in patients with inflammatory bowel disease, specifically in male patients that are younger than 35 years, and have been treated with thiopurine and tumor necrosis factor (TNF)-α inhibitor combination therapy for over 2 years. In this case report we describe a 47-year-old patient with Crohn's disease (CD) who developed HSTCL after having been treated with thiopurine monotherapy for 14 years...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28049351/response
#9
Justin Nissen, Jerome Laval Cyril Dubois
No abstract text is available yet for this article.
January 3, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28041547/-hudinfektion-efter-rejse-i-sydamerika
#10
Thomas Nørrelykke Nissen, Alexandra Kruse
No abstract text is available yet for this article.
December 26, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28040500/a-modification-of-nissen-fundoplication-improves-patients-outcome-and-may-reduce-procedure-related-failure-rate
#11
Romeo Bardini, Sabrina Rampado, Renato Salvador, Lisa Zanatta, Imerio Angriman, Silvia Degasperi, Angelica Ganss, Edoardo Savarino
BACKGROUND: Laparoscopic anti-reflux surgery has a failure rate of 10-20%. We aimed to investigate whether a modification of Nissen fundoplication (MNF) may improve patients' outcome and reduce failure rate. MATERIALS & METHODS: We prospectively compared 40 consecutive patients with gastroesophageal reflux disease who underwent anti-reflux surgery: 20 Nissen fundoplication (NF) and 20 the MNF approach. Eight cases in the MNF group needed redo surgery. The MNF consisted in suturing the esophagus to the diaphragmatic crura on each side by means of 4 non-absorbable stitches and in fixing the upper stitch of the valve to diaphragm...
December 28, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28039654/radiofrequency-energy-delivery-to-the-lower-esophageal-sphincter-improves-gastroesophageal-reflux-patient-reported-outcomes-in-failed-laparoscopic-nissen-fundoplication-cohort
#12
Mark Noar, Patrick Squires, Sulman Khan
BACKGROUND: Patients with uncontrollable gastroesophageal reflux disease (GERD) often undergo laparoscopic Nissen fundoplication (LNF); however, long-term there are often recurring symptoms and need for continuous medication use. Refractory LNF patients may receive radiofrequency energy delivery to the lower esophageal sphincter (Stretta) to ameliorate symptoms and medication requirements. The aim was to assess and compare long-term patient-reported outcomes of Stretta in refractory patients with and without previous LNF...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28032919/expression-of-the-human-isoform-of-glutamate-dehydrogenase-hgdh2-augments-tca-cycle-capacity-and-oxidative-metabolism-of-glutamate-during-glucose-deprivation-in-astrocytes
#13
Jakob D Nissen, Kasper Lykke, Jaroslaw Bryk, Malin H Stridh, Ioannis Zaganas, Dorte M Skytt, Arne Schousboe, Lasse K Bak, Wolfgang Enard, Svante Pääbo, Helle S Waagepetersen
A key enzyme in brain glutamate homeostasis is glutamate dehydrogenase (GDH) which links carbohydrate and amino acid metabolism mediating glutamate degradation to CO2 and expanding tricarboxylic acid (TCA) cycle capacity with intermediates, i.e. anaplerosis. Humans express two GDH isoforms, GDH1 and 2, whereas most other mammals express only GDH1. hGDH1 is widely expressed in human brain while hGDH2 is confined to astrocytes. The two isoforms display different enzymatic properties and the nature of these supports that hGDH2 expression in astrocytes potentially increases glutamate oxidation and supports the TCA cycle during energy-demanding processes such as high intensity glutamatergic signaling...
December 29, 2016: Glia
https://www.readbyqxmd.com/read/28032202/pediatric-obsessive-compulsive-disorder-with-tic-symptoms-clinical-presentation-and-treatment-outcome
#14
Davíð R M A Højgaard, Gudmundur Skarphedinsson, Judith Becker Nissen, Katja A Hybel, Tord Ivarsson, Per Hove Thomsen
: Some studies have shown that children and adolescents with obsessive-compulsive disorder (OCD) and co-morbid tics differ from those without co-morbid tics in terms of several demographic and clinical characteristics. However, not all studies have confirmed these differences. This study examined children and adolescents with OCD and with possible or definite tic specifiers according to the DSM-5 in order to see whether they differ from patients without any tic symptoms regarding clinical presentation and outcome of cognitive behavioral therapy (CBT)...
December 28, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28025156/a-modern-magnetic-implant-for-gastroesophageal-reflux-disease-gerd
#15
Robert A Ganz
A magnetic implant for the treatment of GERD was FDA-approved in 2012 and has been extensively evaluated. The device is a ring of magnets, that are placed around the gastroesophageal junction, augmenting the native lower esophageal sphincter and preventing reflux yet preserving LES physiologic function and allowing belching and vomiting. Magnetic force is advantageous, being permanent and precise, and forces between magnets decrease with esophageal displacement. Multiple patient cohorts have been studied using the magnetic device, and trials establish consistent, long-term improvement in pH data, GERD symptom scores and PPI use...
December 23, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28017412/intracorporal-knot-tying-techniques-which-is-the-right-one
#16
Philipp Romero, Felix Nickel, Maisha Mantel, Giovanni Frongia, Alina Rossler, Karl-Friedrich Kowalewski, Beat Peter Müller-Stich, Patrick Günther
INTRODUCTION: Intracorporal knot tying (ICKT) and suturing in minimal invasive surgery (MIS) represent a key skill for advanced procedures such as Nissen fundoplication. Suture placement under tension is particularly challenging during MIS. The aim of this study was to compare ICKT of the common surgical square knot and the slipping knot on a simulated suture placement under tension. Furthermore, we objectively assessed the surgical skill of ICKT following 3hours of hands-on training...
December 20, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27997505/characterization-and-predictive-value-of-segmental-curve-flexibility-in-adolescent-idiopathic-scoliosis-patients
#17
Guanfeng Yao, Jason Pui Yin Cheung, Hideki Shigematsu, Søren Ohrt-Nissen, Kenneth M C Cheung, Keith D K Luk, Dino Samartzis
STUDY DESIGN: A prospective radiographic analysis of AIS patients managed with alternate-level pedicle screw fixation was performed. OBJECTIVE: The objective of this study was to characterize segmental curve flexibility and to determine its predictive value in curve correction in adolescent idiopathic scoliosis (AIS) patients. SUMMARY OF BACKGROUND DATA: Little is known regarding the distinct segmental curve characteristics and their ability to predict curve correction in patients with AIS...
December 16, 2016: Spine
https://www.readbyqxmd.com/read/27995896/publication-bias-and-the-canonization-of-false-facts
#18
Silas Boye Nissen, Tali Magidson, Kevin Gross, Carl T Bergstrom
Science is facing a "replication crisis" in which many experimental findings cannot be replicated and are likely to be false. Does this imply that many scientific facts are false as well? To find out, we explore the process by which a claim becomes fact. We model the community's confidence in a claim as a Markov process with successive published results shifting the degree of belief. Publication bias in favor of positive findings influences the distribution of published results. We find that unless a sufficient fraction of negative results are published, false claims frequently can become canonized as fact...
December 20, 2016: ELife
https://www.readbyqxmd.com/read/27993385/association-of-tobacco-use-and-cessation-with-coronary-atherosclerosis
#19
Michael K Cheezum, Alexander Kim, Marcio S Bittencourt, David Kassop, Alexander Nissen, Dustin M Thomas, Binh Nguyen, Robert J Glynn, Nishant R Shah, Todd C Villines
BACKGROUND AND AIMS: The impact of tobacco use and cessation on atherogenesis remains unclear. We aimed to study the association of tobacco use and prior cessation with the presence, extent and severity of atherosclerosis on coronary computed tomographic angiography (CTA). METHODS: We examined 1798 consecutive symptomatic patients without known coronary artery disease (CAD) referred for CTA, stratified by smoking status (never, current [within 30 days], or former [>30 days before CTA])...
November 16, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27984486/a-clinicopathological-study-of-malignant-insulinoma-in-a-contemporary-series
#20
Run Yu, Nicholas N Nissen, Andrew Hendifar, Laura Tang, Yu-Li Song, Yuan-Jia Chen, Xuemo Fan
OBJECTIVE: The aim of the study was to address the origin and natural history of malignant insulinoma. METHODS: Retrospective review of medical records of patients diagnosed with insulinoma at Cedars-Sinai Medical Center between 2000 and 2015 was conducted. Hormonal expression in tumor specimens was examined by immunostaining. RESULTS: All the 9 patients with malignant insulinoma (35% of 26 patients with insulinoma) already had liver metastasis at hypoglycemia presentation with bulky cumulative tumor burden...
January 2017: Pancreas
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