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https://www.readbyqxmd.com/read/29776900/the-biopsychosocial-digital-approach-to-health-and-disease-call-for-a-paradigm-expansion
#1
Alireza Ahmadvand, Robert Gatchel, John Brownstein, Lisa Nissen
Digital health is an advancing phenomenon in modern health care systems. Currently, numerous stakeholders in various countries are evaluating the potential benefits of digital health solutions at the individual, population, and/or organizational levels. Additionally, driving factors are being created from the customer-side of the health care systems to push health care providers, policymakers, or researchers to embrace digital health solutions. However, health care providers may differ in their approach to adopt these solutions...
May 18, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29762301/effectiveness-of-nissen-fundoplication-versus-anterior-and-posterior-partial-fundoplications-for-treatment-of-gastro-esophageal-reflux-disease-a-systematic-review-protocol
#2
Matthew Marshall-Webb, Micah D J Peters, Tim Bright, David I Watson
The objective of this review is to determine the relative effectiveness of Nissen fundoplication compared to anterior and posterior partial fundoplication in controlling the symptoms of gastro-esophageal reflux disease and reducing their side effect profile in adults.The specific questions posed by this review are: what is the effectiveness of Nissen fundoplication in comparison to anterior partial fundoplication (90 degree, 120 degree and 180 degree) and posterior 270 degree fundoplication in terms of symptom control of gastro-esophageal reflux disease, and what are the side effects of these surgical interventions?...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761272/primary-paraesophageal-hernia-repair-with-gore%C3%A2-bio-a%C3%A2-tissue-reinforcement-long-term-outcomes-and-association-of-bmi-and-recurrence
#3
Michael T Olson, Saurabh Singhal, Roshan Panchanathan, Sreeja Biswas Roy, Paul Kang, Taylor Ipsen, Sumeet K Mittal, Jasmine L Huang, Michael A Smith, Ross M Bremner
BACKGROUND: Laparoscopic repair remains the gold-standard treatment for paraesophageal hernia (PEH). We analyzed long-term symptomatic outcomes and surgical reintervention rates after primary PEH repair with onlay synthetic bioabsorbable mesh (W. L. Gore & Associates, Inc., Flagstaff, AZ) and examined body mass index (BMI) as a possible risk factor for poor outcomes and for recurrence. METHODS: We queried a prospectively maintained database to identify patients who underwent laparoscopic primary PEH repair with onlay patch of a bioprosthetic absorbable mesh (Bio-A® Gore®) between 05/28/2009 and 12/31/2013...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29754396/the-upper-pouch-in-oesophageal-atresia-shows-proportional-growth-during-late-fetal-life
#4
R B Tröbs, M Nissen, J Wald
Oesophageal atresia with trachea-oesophageal fistula is a rare foregut malformation that requires surgery soon after birth. Prenatal ultrasound diagnosis is based on the presence of polyhydramnios, a small or non-visible fetal stomach and the blind ending oesophagus, called the upper pouch (1). Neonates present with salivation, coughing, choking and attacks of cyanosis. A diagnosis of oesophageal atresia is confirmed by inserting a nasogastric tube and a thoraco-abdominal X-ray. This article is protected by copyright...
May 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29741727/response-to-letters-to-the-editor-by-dr-glozier-and-grunstein-and-by-drs-hertenstein-riemann-and-nissen-in-response-to-our-article-sleep-duration-in-the-united-states-2003-2016-first-signs-of-success-in-the-fight-against-sleep-deficiency
#5
https://www.readbyqxmd.com/read/29740596/neuregulin-1-type-i-overexpression-is-associated-with-reduced-nmda-receptor-mediated-synaptic-signaling-in-hippocampal-interneurons-expressing-pv-or-cck
#6
Dimitrios Kotzadimitriou, Wiebke Nissen, Melinda Paizs, Kathryn Newton, Paul J Harrison, Ole Paulsen, Karri Lamsa
Hypofunction of N -methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder with many susceptibility genes. However, it is still unclear how SZ risk genes interfere with NMDAR-mediated synaptic transmission in diverse inhibitory interneuron populations. One putative risk gene is neuregulin 1 ( NRG1 ), which signals via the receptor tyrosine kinase ErbB4, itself a schizophrenia risk gene. The type I isoform of NRG1 shows increased expression in the brain of SZ patients, and ErbB4 is enriched in GABAergic interneurons expressing parvalbumin (PV) or cholecystokinin (CCK)...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29727008/pro-fhh-a-risk-equation-to-facilitate-the-diagnosis-of-parathyroid-related-hypercalcemia
#7
Jean-Philippe Bertocchio, Muriel Tafflet, Eugénie Koumakis, Gérard Maruani, Rosa Vargas-Poussou, Caroline Silve, Peter H Nissen, Stéphanie Baron, Caroline Prot-Bertoye, Marie Courbebaisse, Jean-Claude Souberbielle, Lars Rejnmark, Catherine Cormier, Pascal Houillier
Context: Parathyroid-related hypercalcemia is due to primary hyperparathyroidism (PHPT) or to familial hypocalciuric hypercalcemia (FHH). PHPT can lead to complications that necessitate parathyroidectomy. FHH is a rare genetic disease resembling PHPT; surgery is ineffective. A reliable method for distinguishing FHH from PHPT is needed. Objective: To develop an easy-to-use tool to predict if a patient has PHPT. Design: Retrospective analysis of two prospective cohorts...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29722088/declarative-virtual-water-maze-learning-and-emotional-fear-conditioning-in-primary-insomnia
#8
Marion Kuhn, Elisabeth Hertenstein, Bernd Feige, Nina Landmann, Kai Spiegelhalder, Chiara Baglioni, Johanna Hemmerling, Diana Durand, Lukas Frase, Stefan Klöppel, Dieter Riemann, Christoph Nissen
Healthy sleep restores the brain's ability to adapt to novel input through memory formation based on activity-dependent refinements of the strength of neural transmission across synapses (synaptic plasticity). In line with this framework, patients with primary insomnia often report subjective memory impairment. However, investigations of memory performance did not produce conclusive results. The aim of this study was to further investigate memory performance in patients with primary insomnia in comparison to healthy controls, using two well-characterized learning tasks, a declarative virtual water maze task and emotional fear conditioning...
May 2, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29718480/sleep-duration-in-the-united-states-a-letter-to-the-editor-commenting-on-the-recent-publication-by-m-basner-and-d-dinges
#9
Elisabeth Hertenstein, Dieter Riemann, Christoph Nissen
No abstract text is available yet for this article.
April 30, 2018: Sleep
https://www.readbyqxmd.com/read/29713813/gastrointestinal-complications-after-lung-transplantation-in-japanese-patients
#10
Hidenao Kayawake, Toyofumi F Chen-Yoshikawa, Hideki Motoyama, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Aoyama, Hiroshi Date
PURPOSE: Gastrointestinal complications after lung transplantation (LTx) are an important postoperative morbidity associated with malnutrition and the malabsorption of drugs. We reviewed our experience of managing gastrointestinal complications after LTx. METHODS: Between June, 2008 and April, 2017, 160 lung transplants were performed at our institution, as living-donor lobar lung transplants in 77 patients, and as deceased-donor lung transplants in 83. We reviewed, retrospectively, the incidence, type and management of gastrointestinal complications...
April 30, 2018: Surgery Today
https://www.readbyqxmd.com/read/29706541/the-egyptian-rousette-genome-reveals-unexpected-features-of-bat-antiviral-immunity
#11
Stephanie S Pavlovich, Sean P Lovett, Galina Koroleva, Jonathan C Guito, Catherine E Arnold, Elyse R Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J Hume, Elke Mühlberger, Luke S Uebelhoer, Jonathan S Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B Kepler, Gustavo Palacios
Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer cell receptors, MHC class I genes, and type I interferons, which dramatically differ from their functional counterparts in other mammals...
April 18, 2018: Cell
https://www.readbyqxmd.com/read/29705754/novel-augmented-reality-solution-for-improving-health-literacy-around-antihypertensives-in-people-living-with-type-2-diabetes-mellitus-protocol-of-a-technology-evaluation-study
#12
Alireza Ahmadvand, Judy Drennan, Jean Burgess, Michele Clark, David Kavanagh, Kara Burns, Sarah Howard, Fleur Kelly, Chris Campbell, Lisa Nissen
INTRODUCTION: Low health literacy is common in people with type 2 diabetes mellitus (T2DM) (up to 40%), associated with decreased self-efficacy in managing T2DM and its important complications, mainly hypertension. This study introduces, for the first time, an easy-to-use solution based on augmented reality (AR) on smartphones, to enhance health literacy around antihypertensive medicines. It assesses the feasibility of the solution for improving health literacy, oriented specifically to angiotensin II receptor blockers; embedding the health literacy improvement into the use cycle of angiotensin II receptor blockers and providing continuous access to information as a form of patient engagement...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29696720/bacterial-biofilms-a-possible-mechanism-for-chronic-infection-in-patients-with-lumbar-disc-herniation-a-prospective-proof-of-concept-study-using-fluorescence-in-situ-hybridization
#13
Søren Ohrt-Nissen, Blaine G Fritz, Jonas Walbom, Kasper N Kragh, Thomas Bjarnsholt, Benny Dahl, Claus Manniche
A relationship has been suggested between lumbar disc herniation (LDH) and chronic bacterial infection frequently involving Propionibacterium acnes, which is known to cause chronic infection through the formation of biofilm aggregates. The objective of the study was to assess whether a disc infection involving biofilm formation is present in patients with LDH. A total of 51 LDH patients and 14 controls were included. Bacterial DNA was detected by real-time polymerase chain reaction (PCR) in 16/51 samples in the LDH group and 7/14 controls (p = 0...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29688503/the-potential-benefits-of-aspirin-for-primary-cardiovascular-prevention-in-rheumatoid-arthritis-a-secondary-analysis-of-the-precision-trial
#14
Daniel H Solomon, Peter Libby, Neville D Yeomans, Qiuqing Wang, Kathy E Wolski, Steven E Nissen, M Elaine Husni
Objective: Guidelines exist for the use of low-dose aspirin in the general population for primary cardiovascular (CV) prevention, but the risk-benefit considerations may differ in RA. While RA confers an increased CV risk, such patients more likely use NSAIDs and corticosteroids. Methods: We conducted a cohort study to assess potential risks and benefits of low-dose aspirin. We estimated incidence rates and hazard ratios (HRs) using Cox regression among subjects with RA but no known CV disease in the Prospective Randomized Evaluation of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen trial...
April 20, 2018: Rheumatology
https://www.readbyqxmd.com/read/29688308/visit-to-visit-cholesterol-variability-correlates-with-coronary-atheroma-progression-and-clinical-outcomes
#15
Donald Clark, Stephen J Nicholls, Julie St John, Mohamed B Elshazly, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen, Rishi Puri
Aims: Utilizing serial intravascular ultrasonography (IVUS), we aimed to exam the association of intra-individual lipid variability, coronary atheroma progression, and clinical outcomes. Methods and results: We performed a post hoc patient-level analysis of nine clinical trials involving 4976 patients with coronary artery disease who underwent serial coronary IVUS in the setting of a range of medical therapies. We assessed the associations between progression in percent atheroma volume (ΔPAV), clinical outcomes, and visit-to-visit lipid variability including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, total cholesterol (TC)/HDL-C, and apolipoprotein B (ApoB)...
April 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29683802/a-study-of-familial-char-syndrome-involving-the-tfap2b-gene-with-a-focus-on-facial-shape-characteristics
#16
Daniel Nyboe, Sven Kreiborg, Tron Darvann, Morten Dunø, Kamilla R Nissen, Hanne B Hove
In this case study, we investigate a child presenting with patent ductus arteriosus, short philtrum, duck-bill lips, strabismus, a flat nasal bridge, a broad forehead, low-set ears, hypertelorism, up-slanting palpebral fissures, almond-shaped eyes, and hypodontia, all leading to the clinical diagnosis of Char syndrome. Genetic analysis showed heterozygosity for the novel variant c.851T>C, p. Leu284Ser in the TFAP2B gene. Family analysis suggested that at least 20 members, extending six generations back, were affected...
April 20, 2018: Clinical Dysmorphology
https://www.readbyqxmd.com/read/29673465/effect-of-aspirin-coadministration-on-the-safety-of-celecoxib-naproxen-or-ibuprofen
#17
Grant W Reed, Mouin S Abdallah, Mingyuan Shao, Kathy Wolski, Lisa Wisniewski, Neville Yeomans, Thomas F Lüscher, Jeffrey S Borer, David Y Graham, M Elaine Husni, Daniel H Solomon, Peter Libby, Venu Menon, A Michael Lincoff, Steven E Nissen
BACKGROUND: The safety of nonsteroidal anti-inflammatory drug (NSAID) and aspirin coadministration is uncertain. OBJECTIVES: The aim of this study was to compare the safety of combining NSAIDs with low-dose aspirin. METHODS: This analysis of the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen) trial included 23,953 patients with osteoarthritis or rheumatoid arthritis at increased cardiovascular risk randomized to celecoxib, ibuprofen, or naproxen...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29667211/randomised-clinical-trial-gastrointestinal-events-in-arthritis-patients-treated-with-celecoxib-ibuprofen-or-naproxen-in-the-precision-trial
#18
N D Yeomans, D Y Graham, M E Husni, D H Solomon, T Stevens, J Vargo, Q Wang, L M Wisniewski, K E Wolski, J S Borer, P Libby, A M Lincoff, T F Lüscher, W Bao, C Walker, S E Nissen
BACKGROUND: We evaluated GI safety of celecoxib compared with 2 nonselective (ns) NSAIDs, as a secondary objective of a large trial examining multiorgan safety. METHODS: This randomised, double-blind controlled trial analysed 24 081 patients. Osteoarthritis or rheumatoid arthritis patients, needing ongoing NSAID treatment, were randomised to receive celecoxib 100-200 mg b.d., ibuprofen 600-800 mg t.d.s. or naproxen 375-500 mg b.d. plus esomeprazole, and low-dose aspirin or corticosteroids if already prescribed...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29660580/an-evaluation-of-kurtosis-beamforming-in-magnetoencephalography-to-localize-the-epileptogenic-zone-in-drug-resistant-epilepsy-patients
#19
Michael B H Hall, Ida A Nissen, Elisabeth C W van Straaten, Paul L Furlong, Caroline Witton, Elaine Foley, Stefano Seri, Arjan Hillebrand
OBJECTIVE: Kurtosis beamforming is a useful technique for analysing magnetoencephalograpy (MEG) data containing epileptic spikes. However, the implementation varies and few studies measure concordance with subsequently resected areas. We evaluated kurtosis beamforming as a means of localizing spikes in drug-resistant epilepsy patients. METHODS: We retrospectively applied kurtosis beamforming to MEG recordings of 22 epilepsy patients that had previously been analysed using equivalent current dipole (ECD) fitting...
March 9, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29660383/dosage-form-modification-and-oral-drug-delivery-in-older-people
#20
Esther T L Lau, Kathryn J Steadman, Julie A Y Cichero, Lisa M Nissen
Many people cannot swallow whole tablets and capsules. The cause ranges from difficulties overriding the natural instinct to chew solids/foodstuff before swallowing, to a complex disorder of swallowing function affecting the ability to manage all food and fluid intake. Older people can experience swallowing difficulties because of co-morbidities, age-related physiological changes, and polypharmacy. To make medicines easier to swallow, many people will modify the medication dosage form e.g. split or crush tablets, and open capsules...
April 13, 2018: Advanced Drug Delivery Reviews
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