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https://www.readbyqxmd.com/read/29146881/beta-adrenergic-signaling-impairs-anti-tumor-cd8-t-cell-responses-to-b-cell-lymphoma-immunotherapy
#1
Michael D Nissen, Erica K Sloan, Stephen R Mattarollo
Beta-adrenergic receptor (betaAR) signaling regulates many physiological processes, including immune system responses. There is growing evidence also for betaAR-induced modulation of cancer growth and metastasis. In the Eu-myc mouse model of B-cell lymphoma, we investigated the effects of chronically elevated betaAR signaling on lymphoma progression and anti-tumor immunity, as well as the impact on cancer immunotherapy. Chronic treatment with the non-selective beta-agonist isoprenaline promoted lymphoma development in a manner dependent on signaling within the hematopoietic compartment...
November 16, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29144454/dynamics-of-p-type-atpase-transport-revealed-by-single-molecule-fret
#2
Mateusz Dyla, Daniel S Terry, Magnus Kjaergaard, Thomas L-M Sørensen, Jacob Lauwring Andersen, Jens Peter Andersen, Charlotte Rohde Knudsen, Roger B Altman, Poul Nissen, Scott C Blanchard
Phosphorylation-type (P-type) ATPases are ubiquitous primary transporters that pump cations across cell membranes through the formation and breakdown of a phosphoenzyme intermediate. Structural investigations suggest that the transport mechanism is defined by conformational changes in the cytoplasmic domains of the protein that are allosterically coupled to transmembrane helices so as to expose ion binding sites to alternate sides of the membrane. Here, we have used single-molecule fluorescence resonance energy transfer to directly observe conformational changes associated with the functional transitions in the Listeria monocytogenes Ca(2+)-ATPase (LMCA1), an orthologue of eukaryotic Ca(2+)-ATPases...
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29130916/the-pendulum-appliance-for-class-ii-non-compliance-therapy
#3
Shannon Hilgers Nissen
No abstract text is available yet for this article.
September 2017: Journal of Clinical Orthodontics: JCO
https://www.readbyqxmd.com/read/29127961/fundoplication
#4
REVIEW
Bethany J Slater, Steven S Rothenberg
Gastroesophageal reflux disease (GERD) is a common condition in infants. Symptoms from pathologic GERD include regurgitation, irritability when feeding, failure to thrive, and respiratory problems. Treatment typically starts with dietary modifications and postural changes. Antireflux medications may then be added. Indications for operative management in neonates and infants include poor weight gain, failure to thrive, acute life-threatening events, and continued respiratory symptoms. Laparoscopic Nissen fundoplication has become the standard of care for surgical treatment of children with GERD...
December 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/29122932/diagnostic-performance-of-an-acoustic-based-system-for-coronary-artery-disease-risk-stratification
#5
Simon Winther, Louise Nissen, Samuel Emil Schmidt, Jelmer Sybren Westra, Laust Dupont Rasmussen, Lars Lyhne Knudsen, Lene Helleskov Madsen, Jane Kirk Johansen, Bjarke Skogstad Larsen, Johannes Jan Struijk, Lars Frost, Niels Ramsing Holm, Evald Høj Christiansen, Hans Erik Botker, Morten Bøttcher
OBJECTIVE: Diagnosing coronary artery disease (CAD) continues to require substantial healthcare resources. Acoustic analysis of transcutaneous heart sounds of cardiac movement and intracoronary turbulence due to obstructive coronary disease could potentially change this. The aim of this study was thus to test the diagnostic accuracy of a new portable acoustic device for detection of CAD. METHODS: We included 1675 patients consecutively with low to intermediate likelihood of CAD who had been referred for cardiac CT angiography...
November 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29119527/multifocality-in-small-bowel-neuroendocrine-tumors
#6
Alexandra Gangi, Emily Siegel, Galinos Barmparas, Simon Lo, Laith H Jamil, Andrew Hendifar, Nicholas N Nissen, Edward M Wolin, Farin Amersi
BACKGROUND: Neuroendocrine tumors (NETs) account for 30% of small bowel (SB) neoplasms. The objectives of this study were to evaluate the incidence of multifocality in primary small bowel neuroendocrine tumors (SBNETs) and to examine the associated outcomes. METHODS: Patients with multifocal SBNET were compared to those with a solitary lesion. Only patients who underwent diagnostic workup and surgical intervention at our institution were included in this study. The primary aim of our study was surgical outcomes and mortality and recurrence...
November 8, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29112715/refseq-an-update-on-prokaryotic-genome-annotation-and-curation
#7
Daniel H Haft, Michael DiCuccio, Azat Badretdin, Vyacheslav Brover, Vyacheslav Chetvernin, Kathleen O'Neill, Wenjun Li, Farideh Chitsaz, Myra K Derbyshire, Noreen R Gonzales, Marc Gwadz, Fu Lu, Gabriele H Marchler, James S Song, Narmada Thanki, Roxanne A Yamashita, Chanjuan Zheng, Françoise Thibaud-Nissen, Lewis Y Geer, Aron Marchler-Bauer, Kim D Pruitt
The Reference Sequence (RefSeq) project at the National Center for Biotechnology Information (NCBI) provides annotation for over 95 000 prokaryotic genomes that meet standards for sequence quality, completeness, and freedom from contamination. Genomes are annotated by a single Prokaryotic Genome Annotation Pipeline (PGAP) to provide users with a resource that is as consistent and accurate as possible. Notable recent changes include the development of a hierarchical evidence scheme, a new focus on curating annotation evidence sources, the addition and curation of protein profile hidden Markov models (HMMs), release of an updated pipeline (PGAP-4), and comprehensive re-annotation of RefSeq prokaryotic genomes...
November 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29110529/impaired-mobility-associated-with-an-increased-likelihood-of-death-in-children-a-systematic-review
#8
Sally Nissen, Edward Purssell, Karen Shaw, Cara Bailey, Nikolaos Efstathiou, Carolyn Dunford
Improved identification of children with an increased likelihood of death can support appropriate provision of integrated palliative care. This systematic review aims to consider immobility and the associated likelihood of death in children with disabilities, living in high-income countries. Two reviewers independently searched MEDLINE, Embase, Cochrane Library, OpenGrey and Science Citation Index (1990-2016) for studies that reported hazard ratios (HRs) and relative risk for the likelihood of death related to impaired mobility...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29109728/invariant-natural-killer-t-cells-in-immune-regulation-of-blood-cancers-harnessing-their-potential-in-immunotherapies
#9
REVIEW
Pui Yeng Lam, Michael D Nissen, Stephen R Mattarollo
Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers. They predominantly recognize glycolipid antigens presented on CD1d, but their activation and cytolytic activities are not confined to CD1d expressing cells. iNKT cell stimulation and subsequent production of immunomodulatory cytokines serve to enhance the overall antitumor immune response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29105657/gait-training-after-spinal-cord-injury-safety-feasibility-and-gait-function-following-8-weeks-of-training-with-the-exoskeletons-from-ekso-bionics
#10
Carsten Bach Baunsgaard, Ulla Vig Nissen, Anne Katrin Brust, Angela Frotzler, Cornelia Ribeill, Yorck-Bernhard Kalke, Natacha León, Belén Gómez, Kersti Samuelsson, Wolfram Antepohl, Ulrika Holmström, Niklas Marklund, Thomas Glott, Arve Opheim, Jesus Benito, Narda Murillo, Janneke Nachtegaal, Willemijn Faber, Fin Biering-Sørensen
STUDY DESIGN: Prospective quasi-experimental study, pre- and post-design. OBJECTIVES: Assess safety, feasibility, training characteristics and changes in gait function for persons with spinal cord injury (SCI) using the robotic exoskeletons from Ekso Bionics. SETTING: Nine European rehabilitation centres. METHODS: Robotic exoskeleton gait training, three times weekly over 8 weeks. Time upright, time walking and steps in the device (training characteristics) were recorded longitudinally...
November 6, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29103605/short-and-long-term-mortality-and-stroke-risk-after-transcatheter-aortic-valve-implantation
#11
Lars Jakobsen, Christian J Terkelsen, Lars Søndergaard, Ole D Backer, Jens Aarøe, Henrik Nissen, Søren P Johnsen, Evald H Christiansen
No published studies have compared the outcome after transcatheter aortic valve implantation (TAVI) with the outcome in the general population. Thus, it is unknown whether TAVI restores normal life expectancy and stroke risk. Furthermore, despite the increasing use of TAVI, only little is known about the temporal trends for TAVI regarding patient characteristics and outcomes. We identified all Danish patients treated with TAVI from 2006 to 2014 (n = 1,631) and 9,737 general population controls matched by gender, age, and co-morbidity...
October 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29096776/one-year-outcome-for-responders-of-cognitive-behavioral-therapy-for-pediatric-obsessive-compulsive-disorder
#12
Davíð R M A Højgaard, Katja A Hybel, Tord Ivarsson, Gudmundur Skarphedinsson, Judith Becker Nissen, Bernhard Weidle, Karin Melin, Nor Christian Torp, Robert Valderhaug, Kitty Dahl, Erik Lykke Mortensen, Scott Compton, Sanne Jensen, Fabian Lenhard, Per Hove Thomsen
OBJECTIVE: This study describes 1-year treatment outcomes from a large sample of cognitive-behavioral therapy (CBT) responders, investigates age as a possible moderator of these treatment outcomes, and evaluates clinical relapse at the 1-year follow-up. METHOD: This study is the planned follow-up to the Nordic Long-term OCD [obsessive-compulsive disorder] Treatment Study (NordLOTS), which included 177 children and adolescents who were rated as treatment responders following CBT for OCD...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29092916/use-of-oral-anticoagulants-in-combination-with-antiplatelet-s-in-atrial-fibrillation
#13
Caroline Sindet-Pedersen, Laila Staerk, Morten Lamberts, Thomas Alexander Gerds, Jeffrey S Berger, Anders Nissen Bonde, Jannik Langtved Pallisgaard, Morten Lock Hansen, Christian Torp-Pedersen, Gunnar H Gislason, Jonas Bjerring Olesen
OBJECTIVES: To investigate temporal trends in the use of non-vitamin K oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) in combination with aspirin and/or clopidogrel in patients with atrial fibrillation (AF) following acute myocardial infarction (MI) and/or percutaneous coronary intervention (PCI). METHODS: Using Danish nationwide registries, all patients with AF who survived 30 days after discharge from MI and/or PCI between 22 August 2011 and 30 September 2016 were identified...
November 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29078917/the-impact-of-the-robotic-platform-on-assistant-variability-in-complex-gastrointestinal-surgery
#14
Maureen D Moore, Cheguevera Afaneh, Katherine D Gray, Suraj Panjwani, Thomas J Fahey, Alfons Pomp, Rasa Zarnegar
BACKGROUND: Nissen fundoplication is considered an advanced minimally invasive procedure whether performed laparoscopically or robotically. In laparoscopic surgery, it is evident that assistant skill level impacts operative times. However, the robotic platform allows improved surgeon autonomy. We aimed to determine the impact of assistant training level on operative times in robotic Nissen fundoplication (RNF) and laparoscopic Nissen fundoplication (LNF). METHODS: A prospectively maintained Nissen database (2011-2016) from a single academic institution was utilized to collect patient characteristics, operative times, length of stay, intraoperative complications, postoperative complications, readmission rate, and assistant training level...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29077663/anesthetic-management-of-a-patient-with-de-novo-hereditary-sensory-and-autonomic-neuropathy-type-vii-a-case-report
#15
Lorenzo Rafer, James Mooney
An 18-month-old patient with hereditary sensory and autonomic neuropathy, type VII undergoing general anesthesia for Nissen fundoplication and gastrostomy tube is presented. This is the first reported case of a patient with this particular genetic mutation receiving general anesthesia. We presented the major intraoperative events during the procedure. The anesthetic considerations and implications of caring for a patient with this particular mutation and patients with other variations of hereditary sensory and autonomic neuropathy are also discussed...
October 26, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29074814/exacerbation-risk-and-characterisation-of-the-uk-s-asthma-population-from-infants-to-old-age
#16
Chloe I Bloom, Francis Nissen, Ian J Douglas, Liam Smeeth, Paul Cullinan, Jennifer K Quint
BACKGROUND: Few studies have examined the characteristics of a general asthma population; most have focused on more severe patients or severe exacerbations. METHODS: This population-based cohort study, from April 2007 to September 2015, used linked primary and secondary care electronic healthcare records (Clinical Practice Research Datalink, Hospital Episode Statistics). Characteristics of four age cohorts, 'Under 5s', '5 to 17s', '18 to 54s', '55+', were described...
October 26, 2017: Thorax
https://www.readbyqxmd.com/read/29064799/gastroesophageal-reflux-disease-the-results-of-videolaparoscopic-fundoplication-at-five-years-after-surgery
#17
Andriy R Stasyshyn
INTRODUCTION: GERD reduces social activity and significantly affects the quality of life (QOL) of patients and the risk of complications (cancer of the esophagus, esophageal-gastric bleeding, strictures, perforation) is one of the most pressing problems of medicine of XXI century. The aim of the research is to evaluate the results of videolaparoscopic fundoplication at five years after surgery in patients with gastroesophageal reflux disease. MATERIAL AND METHODS: We studied results of videolaparoscopic antireflux surgery (VLAS) during 2009-2016 years in Department of Surgery and Endoscopy Faculty of postgraduate medical education Lviv National Medical University...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29058555/auditory-verbal-habilitation-is-associated-with-improved-outcome-for-children-with-cochlear-implant
#18
Lone Percy-Smith, Tenna Lindbjerg Tønning, Jane Lignel Josvassen, Jeanette Hølledig Mikkelsen, Lena Nissen, Eveline Dieleman, Maria Hallstrøm, Per Cayé-Thomasen
OBJECTIVES: To study the impact of (re)habilitation strategy on speech-language outcomes for early, cochlear implanted children enrolled in different intervention programmes post implant. METHODS: Data relate to a total of 130 children representing two pediatric cohorts consisting of 94 and 36 subjects, respectively. The two cohorts had different speech and language intervention following cochlear implantation, i.e. standard habilitation vs. auditory verbal (AV) intervention...
October 23, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/29050717/radiographic-and-functional-outcome-in-adolescent-idiopathic-scoliosis-operated-with-hook-hybrid-versus-all-pedicle-screw-instrumentation-a-retrospective-study-in-149-patients
#19
Søren Ohrt-Nissen, Dennis W Hallager, Ture Karbo, Martin Gehrchen, Benny Dahl
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare radiographic outcome and health-related quality of life in patients with adolescent idiopathic scoliosis (AIS) treated with hook/hybrid (H/H) or all-pedicle screw (PS) instrumentation. SUMMARY OF BACKGROUND DATA: PS instrumentation has largely replaced H/H in the surgical treatment of AIS but whether a normalized sagittal profile can be obtained with the PS construct is still debated...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29049725/cd11b-and-cd200-on-circulating-monocytes-differentiate-two-angiographic-subtypes-of-polypoidal-choroidal-vasculopathy
#20
COMPARATIVE STUDY
Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Akio Oishi, Amardeep Singh, Mogens Holst Nissen, Torben Lykke Sørensen
Purpose: To investigate surface expression of CD11b and CD200 on circulating monocytes in patients with polypoidal choroidal vasculopathy (PCV). Methods: This was a prospective case-control study of patients with PCV (n = 27), age-matched healthy controls (n = 27), and patients with neovascular AMD (n = 49). All participants underwent a comprehensive ocular examination. Fluorescein and indocyanine green angiography were performed in patients suspected of neovascular AMD or PCV...
October 1, 2017: Investigative Ophthalmology & Visual Science
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