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https://www.readbyqxmd.com/read/27926352/3d-laparoscopy-in-neonates-and-infants
#1
Yury Kozlov, Konstantin Kovalkov, Vladimir Nowogilov
BACKGROUND: This study focuses on the successful application of three-dimensional (3D) laparoscopic surgeries in the treatment of congenital anomalies and acquired diseases in the young pediatric population. The purpose of this scientific work consists in highlighting the spectrum, indications, applicability, and effectiveness of 3D endosurgery in children. METHODS: Our experience is based on 110 endosurgical procedures performed in neonates and infants in the 3D format between January 2014 and May 2015...
December 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27922988/minimally-invasive-fundoplication-is-safe-and-effective-in-patients-with-severe-esophageal-hypomotility
#2
Michael B Goldberg, Abbas El-Sayed Abbas, Michael S Smith, Henry P Parkman, Ron Schey, Daniel T Dempsey
OBJECTIVE: Fundoplication is used to treat refractory gastroesophageal reflux disease (GERD). A subset of patients has coexisting esophageal dysmotility, including aperistalsis or hypoperistalsis. These patients may be at increased risk of dysphagia after fundoplication. To evaluate the outcomes of minimally invasive fundoplication (MIF) in patients with GERD and esophageal hypomotility. METHODS: Retrospective review of all patients who underwent MIF and had severe esophageal hypomotility from January 2003 to June 2013...
December 5, 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27918831/induction-of-chemokine-secretion-and-monocyte-migration-by-human-choroidal-melanocytes-in-response-to-proinflammatory-cytokines
#3
Tina Jehs, Carsten Faber, Maja S Udsen, Martine J Jager, Simon J Clark, Mogens H Nissen
Purpose: To determine to which extent inflammatory cytokines affect chemokine secretion by primary human choroidal melanocytes (HCMs), their capacity to attract monocytes, and whether HCMs are able to influence the proliferation of activated T cells. Methods: Primary cultures of HCMs were established from eyes of 13 donors. Human choroidal melanocytes were stimulated with IFN-γ and TNF-α or with supernatant from activated T cells (T-cell-conditioned media [TCM])...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27917800/laparoscopic-nissen-fundoplication-with-mesh-hiatoplasty-single-center-experience-and-early-term-results
#4
Mehmet Tolga Kafadar, Metin Yalaza, Ahmet Türkan, Önder Sürgit, Gürkan Değirmencioğlu, Işilay Nadir
PURPOSE: In this study we report early-term results of laparoscopic Nissen fundoplication with mesh hiatoplasty that we perform to treat gastroesophageal reflux disease. METHODS: We retrospectively reviewed the medical records of 68 patients who underwent laparoscopic Nissen fundoplication with mesh hiatoplasty at our clinic. Thirty-six (53%) patients were male and 32 (47%) were female. The mean age of the study population was 46.1 (25-72) years. All patients underwent endoscopy, esophagus pH metry and manometry before the operation...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27913609/ap2s1-and-gna11-mutations-not-a-common-cause-of-familial-hypocalciuric-hypercalcemia
#5
Silje Hovden, Lars Rejnmark, Søren A Ladefoged, Peter H Nissen
OBJECTIVE: Familial hypocalciuric hypercalcemia (FHH) type 1 is caused by mutations in the gene encoding the calcium-sensing receptor (CASR). Recently, mutations affecting codon 15 in the gene AP2S1 have been shown to cause FHH type 3 in up to 26% of CASR-negative FHH patients. Similarly, mutations in the gene GNA11 have been shown to cause FHH type 2. We hypothesized that mutations in AP2S1 and GNA11 are causative in Danish patients with suspected FHH and that these mutations are not found in patients with primary hyperparathyroidism (PHPT), which is the main differential diagnostic disorder...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27901639/results-of-laparoscopic-heller-s-myotomy-for-achalasia-in-children-a-systematic-review-of-the-literature
#6
Maurizio Pacilli, Mark Davenport
INTRODUCTION: Achalasia is a rare disorder in children who are commonly treated by laparoscopic Heller's myotomy (LHM). However, there are no large studies evaluating the results of LHM in the pediatric population, and the need of a concomitant fundoplication remains unclear. The aim of the study is to appraise the results of LHM based on a systematic literature review. MATERIALS AND METHODS: MEDLINE search of the English literature was performed for "achalasia," "children," "laparoscopy," "Heller," "myotomy," and "cardiomyotomy...
November 30, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27890313/laparoscopic-fundoplication-in-neonates-and-young-infants-failure-rate-and-need-for-redo-at-a-high-volume-center
#7
Pablo Laje, Thane A Blinman, Michael L Nance, William H Peranteau
AIM OF THE STUDY: Present the outcomes of patients younger than 2years who underwent laparoscopic fundoplication, highlighting the failure rate and need for redo fundoplication. METHODS: Retrospective review of patients <2years who underwent laparoscopic fundoplication between January 2009 and December 2014. MAIN RESULTS: 458 infants younger than 2years underwent laparoscopic fundoplication in the 6-year period (360 Nissen, 77 Toupet and 21 Thal fundoplications)...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27889826/cardiovascular-risk-profiles-in-a-hospital-based-population-of-patients-with-psoriatic-arthritis-and-ankylosing-spondylitis-a-cross-sectional-study
#8
Christoffer B Nissen, Kim Hørslev-Petersen, Jette Primdahl
The objective of the study was to investigate the frequency of traditional risk factors for the cardiovascular (CV) disease, to calculate the Systematic COronary Risk Evaluation (SCORE) for CV-related mortality in Danish patients with psoriatic arthritis (PsA) and ankylosing spondylitis (AS), and to compare with results from patients with rheumatoid arthritis (RA) from the same settlement. All PsA and AS patients aged 18-85 years from one outpatient clinic were invited. A rheumatology nurse conducted 30-min screening consultation, preceded by a lipid and glucose profile...
November 26, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27888520/identifying-the-epileptogenic-zone-in-interictal-resting-state-meg-source-space-networks
#9
Ida A Nissen, Cornelis J Stam, Jaap C Reijneveld, Ilse E C W van Straaten, Eef J Hendriks, Johannes C Baayen, Philip C De Witt Hamer, Sander Idema, Arjan Hillebrand
OBJECTIVE: In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform activity. Our aim was to identify the epileptogenic zone on the basis of hub status of local brain areas in interictal magnetoencephalography (MEG) networks. METHODS: Preoperative eyes-closed resting-state MEG recordings were retrospectively analyzed in 22 patients with refractory epilepsy, of whom 14 were seizure-free 1 year after surgery...
November 26, 2016: Epilepsia
https://www.readbyqxmd.com/read/27888302/-macrophages-causing-ocular-metastasis-or-immune-reaction-on-tumor-cells-in-the-eye
#10
M I Wunderlich, E J Nissen, M Schargus, H B Dick, M Pohl, S E Coupland, V Kakkassery
No abstract text is available yet for this article.
November 25, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27887981/predictors-of-mortality-in-the-critically-ill-cirrhotic-patient-is-the-model-for-end-stage-liver-disease-enough
#11
Alagappan Annamalai, Megan Y Harada, Melissa Chen, Tram Tran, Ara Ko, Eric J Ley, Miriam Nuno, Andrew Klein, Nicholas Nissen, Mazen Noureddin
BACKGROUND: Critically ill cirrhotics urgently require liver transplantation but are at high risk for perioperative mortality. The Model for End-Stage Liver Disease (MELD) score, recently updated to incorporate serum sodium, estimates survival probability in patients with cirrhosis but needs further evaluation in the critically ill. The purpose of this study was to evaluate the predictive power of intensive care unit (ICU) admission MELD scores and identify clinical risk factors associated with increased mortality...
November 22, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27880803/wdr68-mediates-dorsal-and-ventral-patterning-events-for-craniofacial-development
#12
Estibaliz Alvarado, Mina Yousefelahiyeh, Greg Alvarado, Robin Shang, Taryn Whitman, Andrew Martinez, Yang Yu, Annie Pham, Anish Bhandari, Bingyan Wang, Robert M Nissen
Birth defects are among the leading causes of infant mortality and contribute substantially to illness and long-term disability. Defects in Bone Morphogenetic Protein (BMP) signaling are associated with cleft lip/palate. Many craniofacial syndromes are caused by defects in signaling pathways that pattern the cranial neural crest cells (CNCCs) along the dorsal-ventral axis. For example, auriculocondylar syndrome is caused by impaired Endothelin-1 (Edn1) signaling, and Alagille syndrome is caused by defects in Jagged-Notch signaling...
2016: PloS One
https://www.readbyqxmd.com/read/27870536/teaching-advanced-flow-cytometry-in-africa-10-years-of-lessons-learned
#13
Elisa Nemes, Wendy A Burgers, Catherine Riou, Erica Andersen-Nissen, Guido Ferrari, Clive M Gray, Thomas Scriba
No abstract text is available yet for this article.
November 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/27866049/novel-eln-mutation-in-a-family-with-supravalvular-aortic-stenosis-and-intracranial-aneurysm
#14
Anne Marie Jelsig, Zsolt Urban, Vishwanathan Hucthagowder, Henrik Nissen, Lilian Bomme Ousager
Pathogenic germline mutations in ELN can be detected in patients with supravalvular aortic stenosis. The mutation might occur de novo or be inherited following an autosomal dominant pattern of inheritance. In this report we describe a three-generation family suffering from supravalvular aortic stenosis, various other arterial stenoses, sudden death, and intracranial aneurysms. A frameshift mutation in exon 12, not described before, was detected in the affected family members. This report emphasises the importance of family history, genetic counselling, and demonstrates the great variability in the phenotype within a single SVAS family...
November 16, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27862469/araport11-a-complete-reannotation-of-the-arabidopsis-thaliana-reference-genome
#15
Chia-Yi Cheng, Vivek Krishnakumar, Agnes Chan, Françoise Thibaud-Nissen, Seth Schobel, Christopher D Town
The flowering plant Arabidopsis thaliana is a dicot model organism for research in many aspects of plant biology. A comprehensive annotation of its genome paves the way for understanding the functions and activities of all types of transcripts, including mRNA, the various classes of non-coding RNA, and small RNA. The TAIR10 annotation update had a profound impact on Arabidopsis research but was released more than five years ago. Maintaining the accuracy of the annotation continues to be a prerequisite for future progress...
November 8, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27856358/p2x7rs-are-involved-in-cell-death-growth-and-cellular-signaling-in-primary-human-osteoblasts
#16
Ankita Agrawal, Zanne Henriksen, Susanne Syberg, Solveig Petersen, Derya Aslan, Marie Solgaard, Nis Nissen, Tommy Korsgaard Larsen, Peter Schwarz, Thomas H Steinberg, Niklas Rye Jørgensen
The ionotropic ATP-gated P2X7 receptor (P2X7R) is involved in the regulation of many physiological functions including bone metabolism. Several studies on osteoblasts from rodents and human osteoblast-like cell lines have addressed the expression and function of P2X7R on these bone-forming cells however; its role in human primary osteoblasts has not yet been reported. The aim of this study was to assess the expression of the P2X7R in bone marrow-derived stromal cells and in primary human trabecular osteoblasts and to determine the function in bone formation and cell signaling...
November 14, 2016: Bone
https://www.readbyqxmd.com/read/27852011/a-new-chicken-genome-assembly-provides-insight-into-avian-genome-structure
#17
Wesley C Warren, LaDeana W Hillier, Chad Tomlinson, Patrick Minx, Milinn Kremitzki, Tina Graves, Chris Markovic, Nathan Bouk, Kim D Pruitt, Francoise Thibaud-Nissen, Valerie Schneider, Tamer A Mansour, C Titus Brown, Aleksey Zimin, Rachel Hawken, Mitch Abrahamsen, Alexis B Pyrkosz, Mireille Morisson, Valerie Fillon, Alain Vignal, William Chow, Kerstin Howe, Janet E Fulton, Marcia M Miller, Peter Lovell, Claudio V Mello, Morgan Wirthlin, Andrew S Mason, Richard Kuo, David W Burt, Jerry B Dodgson, Hans H Cheng
The importance of the Gallus gallus (chicken) as a model organism and agricultural animal merits a continuation of sequence assembly improvement efforts. We present a new version of the chicken genome assembly (Gallus_gallus-5.0; GCA_000002315.3) built from combined long single molecule sequencing technology, finished BACs, and improved physical maps. In overall assembled bases, we see a gain of 183 Mb including 16.4 Mb in placed chromosomes with a corresponding gain in the percentage of intact repeat elements characterized...
November 14, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27849511/hiatal-hernia-as-the-cause-of-g-induced-abdominal-pain
#18
Scott B Hughey, Lauren H Mattingly
Sliding hiatal hernias are common and affect approximately 10% to 80% of the general population. The condition typically presents with reflux-type symptoms and is diagnosed either with imaging or endoscopy. In this case, the hernia presented as G-induced abdominal pain. The patient was an F-18 pilot who experienced worsening epigastric abdominal pain proportionate to the amount of accelerative force experienced. The pain would occur at approximately 3 Gs and increase beyond that. The patient was asymptomatic at rest and denied any dysphagia or reflux symptoms...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27849501/danish-gulf-war-veterans-revisited-no-evidence-of-increased-sickness-absence-or-reduced-labor-market-outcome-after-deployment-to-the-persian-gulf
#19
Lars Ravnborg Nissen, Christian Stoltenberg, Anni B Sternhagen Nielsen, Mia S Vedtofte, Jacob L Marott, Finn Gyntelberg, Bernadette Guldager
OBJECTIVE: To examine the assumption that postdeployment incidence of sickness and other absence from work are higher among Gulf War Veterans compared with nonveterans. METHODS: A prospective registry study including a cohort of 721 Danish Gulf War Veterans and a control cohort of 3,629 nonveterans selected from the general Danish population. Outcome measures were up to 23 years postdeployment incidence of (1) long-term sickness absence and (2) long-term all types of absence from work...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27846344/effect-of-evolocumab-on-progression-of-coronary-disease-in-statin-treated-patients-the-glagov-randomized-clinical-trial
#20
Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Robert Scott, Imre Ungi, Jakub Podolec, Antonius Oude Ophuis, Jan H Cornel, Marilyn Borgman, Danielle M Brennan, Steven E Nissen
Importance: Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive statin therapy reduces progression of coronary atherosclerosis in proportion to achieved LDL-C levels. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental LDL-C lowering in statin-treated patients; however, the effects of these drugs on coronary atherosclerosis have not been evaluated. Objective: To determine the effects of PCSK9 inhibition with evolocumab on progression of coronary atherosclerosis in statin-treated patients...
November 15, 2016: JAMA: the Journal of the American Medical Association
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