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Pregnant gadolinium

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https://www.readbyqxmd.com/read/29689556/assessment-of-placental-perfusion-in-the-preeclampsia-l-name-rat-model-with-high-field-dynamic-contrast-enhanced-mri
#1
Marie Lémery Magnin, Victor Fitoussi, Nathalie Siauve, Laetitia Pidial, Daniel Balvay, Gwennhael Autret, Charles André Cuenod, Olivier Clément, Laurent Julien Salomon
PURPOSE: To evaluate placental function and perfusion in a rat model of preeclampsia infused with L-nitro-arginine methyl ester (L-NAME) by dynamic contrast-enhanced (DCE) MRI using gadolinium chelates. METHODS: Pregnant female Sprague-Dawley rats were fitted on embryonic day 16 (E16) with subcutaneous osmotic minipumps loaded to deliver, continuously, L-NAME (50 mg/day per rat; case group) or saline solution (control group). DCE MRI was performed on E19 using gadolinium chelates and a 4...
April 24, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29465714/preeclampsia-induced-by-stox1-overexpression-in-mice-induces-intrauterine-growth-restriction-abnormal-ultrasonography-and-bold-mri-signatures
#2
Hélène Collinot, Carmen Marchiol, Isabelle Lagoutte, Franck Lager, Nathalie Siauve, Gwennhael Autret, Daniel Balvay, Gilles Renault, Laurent J Salomon, Daniel Vaiman
BACKGROUND: Preeclampsia is a major hypertensive disease caused by pregnancy, inducing proteinuria and increased blood pressure starting from the second half of pregnancy (early preeclampsia) or near the end of pregnancy (late preeclampsia). Pre-symptomatic diagnosis would allow for therapeutic interventions, such as with low-dose aspirin. Among non-invasive methods to explore organ physiology, Doppler ultrasonography (US) and functional blood oxygenation level-dependent (BOLD) MRI (which do not need radioactive contrast agents such as gadolinium) can be used in pregnant women...
June 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/28964468/safety-of-contrast-material-use-during-pregnancy-and-lactation
#3
REVIEW
Paulo Puac, Andrés Rodríguez, Carina Vallejo, Carlos A Zamora, Mauricio Castillo
The use of contrast media to image patients who are pregnant has increased during the past decades worldwide. Their use in pregnancy and in patients who are lactating remains a challenging issue for radiologists and other physicians. This article addresses the different types of contrast media that may be used in such patients according to the imaging modality (iodinated contrast media, barium, gadolinium-based, and ultrasound contrast agents), focusing on their adverse effects, potential teratogenic effects, strategies to minimize risks, and current clinical recommendation...
November 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28915162/the-effect-of-perinatal-gadolinium-based-contrast-agents-on-adult-mice-behavior
#4
Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Hiroshi Koyama, Yoshito Tsushima, Noriyuki Koibuchi
OBJECTIVES: The aim of this study was to examine the effects of perinatal exposure to gadolinium (Gd)-based contrast agents (GBCAs) on the behavior of adulthood offspring. MATERIALS AND METHODS: Pregnant Balb/C mice (n = 5 per group) were intravenously injected with gadoterate meglumine (Magnescope, macrocyclic GBCA), gadodiamide (Omniscan, linear GBCA), or vehicle from pregnancy day 15 to 19, corresponding to embryonic day 15 to 19 of the fetus, at 2 mmol/kg body weight per day...
February 2018: Investigative Radiology
https://www.readbyqxmd.com/read/28864020/pre-clinical-evaluation-of-a-nanoparticle-based-blood-pool-contrast-agent-for-mr-imaging-of-the-placenta
#5
Ketan B Ghaghada, Zbigniew A Starosolski, Saakshi Bhayana, Igor Stupin, Chandreshkumar V Patel, Rohan C Bhavane, Haijun Gao, Andrey Bednov, Chandrasekhar Yallampalli, Michael Belfort, Verghese George, Ananth V Annapragada
INTRODUCTION: Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of the placental margins and the placental-myometrial interface (retroplacental space). Non-contrast MRI and contrast-enhanced MRI using a clinically approved conventional contrast agent were used as comparators...
September 2017: Placenta
https://www.readbyqxmd.com/read/28730467/organ-retention-of-gadolinium-in-mother-and-pup-mice-effect-of-pregnancy-and-type-of-gadolinium-based-contrast-agents
#6
Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Miski Aghnia Khairinisa, Oyunbold Lamid-Ochir, Amartuvshin Tumenjargal, Noriyuki Koibuchi, Hiroshi Koyama, Yoshito Tsushima
PURPOSE: To investigate the effect of pregnancy and type of gadolinium (Gd)-based contrast agents (GBCAs) on organ retention of Gd in mother and pup mice after maternal administration. MATERIALS AND METHODS: Gd-DTPA-BMA (gadodiamide) or Gd-DOTA (gadoterate dimeglumine) was administered (2.0 mmol/kg of maternal weight) four times to pregnant Balb/c mice from gestational day 16-19, respectively. At 28 days after birth, they were euthanized and their organs (blood, brain, liver, kidney, spleen, and bone) were removed for the measurement of Gd by inductively coupled plasma mass spectrometry...
October 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27748714/incidence-and-risk-factors-for-gadolinium-based-contrast-agent-immediate-reactions
#7
REVIEW
James R Costello, Bobby Kalb, Diego R Martin
Since their clinical introduction in 1988, gadolinium-based contrast agents (GBCAs) have demonstrated an excellent safety profile with a reported acute adverse reaction rate ranging from 0.01% to 2%. By comparison, the acute adverse reaction rate of low osmolar nonionic computed tomography contrast agents (CTCs) ranges from 0.7% to 3.1%. Many of the risk factors associated with CTC reactions (drug allergies, asthma, atopy, prior contrast reaction) also point toward an increased incidence of acute adverse events to GBCAs...
December 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27460749/evolving-practice-patterns-in-imaging-pregnant-patients-with-acute-abdominal-and-pelvic-conditions
#8
REVIEW
Wendy Hansen, Mariam Moshiri, Angelisa Paladin, Ramit Lamba, Douglas S Katz, Puneet Bhargava
OBJECTIVE: The purpose of our study was to determine the current practice patterns of U.S. radiologists in imaging pregnant or potentially pregnant patients with acute abdominal and pelvic conditions. MATERIALS AND METHODS: After obtaining an Institutional Review Board waiver, all members of the Association of University Radiologists, the Association of Program Directors in Radiology, and the Society of Radiologists in Ultrasound were invited via e-mail to take a 23-question online survey on radiology practices and clinical scenarios about acute abdominal and pelvic imaging of pregnant patients...
January 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/27373694/practical-applications-of-balanced-steady-state-free-precession-bssfp-imaging-in-the-abdomen-and-pelvis
#9
REVIEW
Nicola Schieda, Inga Isupov, Andrew Chung, Niamh Coffey, Leonard Avruch
Balanced steady-state free-precession (bSSFP) is an important pulse sequence that may be underutilized in abdominal and pelvic magnetic resonance imaging (MRI). bSSFP offers several advantages for abdominal and pelvic MRI that include: bright blood effects, a relative insensitivity to the dephasing effects which occur in structures with linear movement, low specific absorption rate (SAR), high signal-to-noise ratio (SNR), high spatial resolution, and rapid acquisition times. Bright blood effects can be exploited to diagnose or confirm vascular pathologies when gadolinium-enhanced imaging cannot be performed, is indeterminate, or is degraded by artifact...
January 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27346286/magnetic-resonance-imaging-for-abnormally-invasive-placenta-the-added-value-of-intravenous-gadolinium-injection
#10
A-E Millischer, L J Salomon, R Porcher, M Brasseur-Daudruy, A-L Gourdier, P Hornoy, S Silvera, D Loisel, V Tsatsaris, B Delorme, N Boddaert, Y Ville, L Sentilhes
OBJECTIVES: To assess the added value of intravenous gadolinium injection to magnetic resonance imaging (MRI) -based diagnosis of abnormally invasive placenta (AIP) and to examine this in relation to the radiologist's experience. DESIGN: Retrospective study. SETTING: Between March 2009 and October 2012, 31 pregnant women who had previous caesarean delivery together with a placenta praevia and suspected placenta accreta on ultrasound in the third trimester of pregnancy...
January 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27298076/a-liposomal-gd-contrast-agent-does-not-cross-the-mouse-placental-barrier
#11
COMPARATIVE STUDY
Anil N Shetty, Robia Pautler, Ketan Ghaghada, David Rendon, Haijun Gao, Zbigniew Starosolski, Rohan Bhavane, Chandreshkumar Patel, Ananth Annapragada, Chandrasekhar Yallampalli, Wesley Lee
The trans-placental permeability of liposomal Gadolinium (Gd) nanoparticle contrast agents was evaluated in a pregnant mouse model. Pregnant Balb/c mice at 16.5 (±1) days of gestation were imaged using a 3D Spoiled Gradient Echo method at 9.4 T using two contrast agents: a clinically approved Gd chelate, Multihance(®) (gadobenate dimeglumine), and a novel experimental liposomal Gd agent. A Dynamic Contrast Enhancement (DCE) protocol was used to capture the dynamics of contrast entry and distribution in the placenta, and clearance from circulation...
June 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26942391/committee-opinion-no-656-guidelines-for-diagnostic-imaging-during-pregnancy-and-lactation
#12
(no author information available yet)
Imaging studies are important adjuncts in the diagnostic evaluation of acute and chronic conditions. However, confusion about the safety of these modalities for pregnant and lactating women and their infants often results in unnecessary avoidance of useful diagnostic tests or the unnecessary interruption of breastfeeding. Ultrasonography and magnetic resonance imaging are not associated with risk and are the imaging techniques of choice for the pregnant patient, but they should be used prudently and only when use is expected to answer a relevant clinical question or otherwise provide medical benefit to the patient...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26942384/committee-opinion-no-656-summary-guidelines-for-diagnostic-imaging-during-pregnancy-and-lactation
#13
REVIEW
(no author information available yet)
Imaging studies are important adjuncts in the diagnostic evaluation of acute and chronic conditions. However, confusion about the safety of these modalities for pregnant and lactating women and their infants often results in unnecessary avoidance of useful diagnostic tests or the unnecessary interruption of breastfeeding. Ultrasonography and magnetic resonance imaging are not associated with risk and are the imaging techniques of choice for the pregnant patient, but they should be used prudently and only when use is expected to answer a relevant clinical question or otherwise provide medical benefit to the patient...
February 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26466183/imaging-pregnant-and-lactating-patients
#14
REVIEW
Nikki Tirada, David Dreizin, Nadia J Khati, Esma A Akin, Robert K Zeman
As use of imaging in the evaluation of pregnant and lactating patients continues to increase, misperceptions of radiation and safety risks have proliferated, which has led to often unwarranted concerns among patients and clinicians. When radiologic examinations are appropriately used, the benefits derived from the information gained usually outweigh the risks. This review describes appropriateness and safety issues, estimated doses for imaging examinations that use iodizing radiation (ie, radiography, computed tomography, nuclear scintigraphy, and fluoroscopically guided interventional radiology), radiation risks to the mother and conceptus during various stages of pregnancy, and use of iodinated or gadolinium-based contrast agents and radiotracers in pregnant and lactating women...
October 2015: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/26334607/guidelines-for-the-management-of-a-pregnant-trauma-patient
#15
Venu Jain, Radha Chari, Sharon Maslovitz, Dan Farine, Emmanuel Bujold, Robert Gagnon, Melanie Basso, Hayley Bos, Richard Brown, Stephanie Cooper, Katy Gouin, N Lynne McLeod, Savas Menticoglou, William Mundle, Christy Pylypjuk, Anne Roggensack, Frank Sanderson
OBJECTIVE: Physical trauma affects 1 in 12 pregnant women and has a major impact on maternal mortality and morbidity and on pregnancy outcome. A multidisciplinary approach is warranted to optimize outcome for both the mother and her fetus. The aim of this document is to provide the obstetric care provider with an evidence-based systematic approach to the pregnant trauma patient. OUTCOMES: Significant health and economic outcomes considered in comparing alternative practices...
June 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/26220129/-new-aspects-from-legislation-guidelines-and-safety-standards-for-mri
#16
M Mühlenweg, G Schaefers, S Trattnig
Many aspects of magnetic resonance (MR) operation are not directly regulated by law but in standards, guidelines and the operating instructions of the MR scanner. The mandatory contents of the operating instructions are regulated in a central standard of the International Electrotechnical Commission (IEC) 60601-2-33. In this standard, the application of static magnetic fields in MRI up to 8 Tesla (T) in the clinical routine (first level controlled mode) has recently been approved. Furthermore, the equally necessary CE certification of ultra-high field scanners (7-8 T) in Europe is expected for future devices...
August 2015: Der Radiologe
https://www.readbyqxmd.com/read/26134120/sodium-leak-channel-non-selective-contributes-to-the-leak-current-in-human-myometrial-smooth-muscle-cells-from-pregnant-women
#17
Erin L Reinl, Rafael Cabeza, Ismail A Gregory, Alison G Cahill, Sarah K England
Uterine contractions are tightly regulated by the electrical activity of myometrial smooth muscle cells (MSMCs). These cells require a depolarizing current to initiate Ca(2+) influx and induce contraction. Cationic leak channels, which permit a steady flow of cations into a cell, are known to cause membrane depolarization in many tissue types. Previously, a Gd(3+)-sensitive, Na(+)-dependent leak current was identified in the rat myometrium, but the presence of such a current in human MSMCs and the specific ion channel conducting this current was unknown...
October 2015: Molecular Human Reproduction
https://www.readbyqxmd.com/read/26033169/a-case-series-of-15-women-inadvertently-exposed-to-magnetic-resonance-imaging-in-the-first-trimester-of-pregnancy
#18
J S Choi, H K Ahn, J Y Han, Y J Han, D O Kwak, E Y Velazquez-Armenta, A A Nava-Ocampo
Information on the safety of first-trimester exposure to diagnostic magnetic resonance imaging (MRI) remains scarce. We are reporting a case series of 15 consecutive pregnant women who underwent an MRI scan with a 1.5-Tesla scanner of either the head (n = 5), cervical spine (n = 4), lumbar spine (n = 4), pelvis (n = 1) or knee (n = 1) in their first trimester of pregnancy (mean gestational age at exposure: 3.8 weeks). Patients were prospectively followed up until the completion of their pregnancy. Two cases received gadolinium as a contrast agent...
2015: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/25304299/-gadolinium-based-contrast-agents-for-magnetic-resonance-imaging
#19
S Carrasco Muñoz, C Calles Blanco, Javier Marcin, C Fernández Álvarez, J Lafuente Martínez
Gadolinium-based contrast agents are increasingly being used in magnetic resonance imaging. These agents can improve the contrast in images and provide information about function and metabolism, increasing both sensitivity and specificity. We describe the gadolinium-based contrast agents that have been approved for clinical use, detailing their main characteristics based on their chemical structure, stability, and safety. In general terms, these compounds are safe. Nevertheless, adverse reactions, the possibility of nephrotoxicity from these compounds, and the possibility of developing nephrogenic systemic fibrosis will be covered in this article...
June 2014: Radiología
https://www.readbyqxmd.com/read/25129422/magnetic-resonance-enterography-in-pregnant-women-with-crohn-s-disease-case-series-and-literature-review
#20
REVIEW
Myriam D Stern, Uri Kopylov, Shomron Ben-Horin, Sarah Apter, Marianne Michal Amitai
BACKGROUND: Evaluation of pregnant women with known or suspected Crohn's disease (CD) remains a challenge. Magnetic Resonance Enterography (MRE) is a promising diagnostic tool in these patients; however, the clinical data on MRE utilization in pregnancy is scarce. The aim of the study was to describe the experience with MRE in pregnant CD patients in a tertiary referral center. METHODS: We retrospectively reviewed MRE studies performed in pregnant women with known or suspected CD that were performed between January 2007 and November 2012...
August 16, 2014: BMC Gastroenterology
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