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https://www.readbyqxmd.com/read/28454482/effects-of-environmental-factors-and-metallic-electrodes-on-ac-electrical-conduction-through-dna-molecule
#1
S Abdalla, A Obaid, F M Al-Marzouki
BACKGROUND: Deoxyribonucleic acid (DNA) is one of the best candidate materials for various device applications such as in electrodes for rechargeable batteries, biosensors, molecular electronics, medical- and biomedical-applications etc. Hence, it is worthwhile to examine the mechanism of charge transport in the DNA molecule, however, still a question without a clear answer is DNA a molecular conducting material (wire), semiconductor, or insulator? The answer, after the published data, is still ambiguous without any confirmed and clear scientific answer...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454477/in-situ-analysis-of-oxygen-vacancies-and-band-alignment-in-hfo2-tin-structure-for-cmos-applications
#2
Da-Peng Xu, Lin-Jie Yu, Xu-Dong Chen, Lin Chen, Qing-Qing Sun, Hao Zhu, Hong-Liang Lu, Peng Zhou, Shi-Jin Ding, David Wei Zhang
The density of oxygen vacancies characterization in high-k/metal gate is significant for semiconductor device fabrication. In this work, a new approach was demonstrated to detect the density of oxygen vacancies by in situ x-ray photoelectron spectroscopy (XPS) and ultraviolet photoelectron spectroscopy (UPS) measurement. Moreover, the band alignment of the structure with optical band gap measured by spectroscopic ellipsometry (SE) and valence band offset by UPS were reported. The specific areal density of oxygen vacancies in high-k dielectric of HfO2/TiN was obtained by fitting the experiment data to be 8...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454422/the-role-of-mrp1-in-the-multidrug-resistance-of-colorectal-cancer
#3
Dongxing Cao, Shaolan Qin, Yifei Mu, Ming Zhong
The role of multidrug resistance associated protein 1 (MRP1) in the multidrug resistance (MDR) of colorectal cancer (CRC) remains unclear. The present study aimed to investigate the effect of MRP1 in MDR CRC and its therapeutic potential for the treatment of patients with this disease. The human MDR CRC cell lines HCT-8 and Colo205 were established through stable exposure to 5-florouracil (5-FU) over a 5-month period. MRP1 was knocked-down in MDR CRC cells through the transfection of short hairpin RNA targeting MRP1 (shMRP1)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454381/optimized-construction-of-muc1-vntrn-dna-vaccine-and-its-anti-pancreatic-cancer-efficacy
#4
Yuan-Feng Gong, Quan-Bo Zhou, Ya-Di Liao, Cong Mai, Tie-Jun Chen, Yun-Qiang Tang, Ru-Fu Chen
Considering mucin 1-variable number tandem repeat (MUC1-VNTRn) as a novel target for pancreatic cancer immunotherapy, the present study aimed to screen and identify the pVAX1-MUC1-VNTRn DNA vaccine with the strongest immunogenicity. Following construction of a pVAX1-MUC1-VNTRn plasmid, immature dendritic cells (DCs) were subjected to transfection, and mature DCs were then co-cultured with autologous T-cells. The numbers of cytotoxic T lymphocytes (CTLs) secreting interferon (IFN)-γ were determined using an enzyme-linked immunospot assay, and CytoTox(®) was also used to examine the MUC1-VNTRn-specific Lethal effect of CTLs on Capan2 cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454358/prognostic-relevance-of-dna-flow-cytometry-in-breast-cancer-revisited-the-25-year-experience-of-the-portuguese-institute-of-oncology-of-lisbon
#5
António E Pinto, Teresa Pereira, Giovani L Silva, Saudade André
The potential prognostic significance of DNA flow cytometric measurements (DNA ploidy and S-phase fraction) in breast cancer remains in dispute. Inconclusive data, primarily due to the lack of consistent standardization and quality control programs, have limited its translation into clinical practice. The aim of the present review, based on the 25-year experience of the Portuguese Institute of Oncology of Lisbon, is to assess the clinical relevance and application of DNA flow cytometry for the prognosis of breast cancer...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454342/feasibility-and-antitumor-efficacy-in-vivo-of-simultaneously-targeting-glycolysis-glutaminolysis-and-fatty-acid-synthesis-using-lonidamine-6-diazo-5-oxo-l-norleucine-and-orlistat-in-colon-cancer
#6
Diana Cervantes-Madrid, Guadalupe Dominguez-Gomez, Aurora Gonzalez-Fierro, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Alfonso Duenas-Gonzalez
The aim of the present study was to investigate in vivo the feasibility and efficacy of the combination of lonidamine (LND), 6-diazo-5-oxo-L-norleucine (DON) and orlistat to simultaneously target glycolysis, glutaminolysis and de novo synthesis of fatty acids, respectively. The doses of LND and DON used in humans were translated to mouse doses (77.7 mg/kg and 145.5 mg/kg, respectively) and orlistat was used at 240 mg/kg. Three schedules of LND, DON and orlistat at different doses were administered by intraperitoneal injection to BALB/c mice in a 21-day cycle (schedule 1: LND, 0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454333/a-polysaccharide-component-from-strongylocentrotus-nudus-eggs-inhibited-hepatocellular-carcinoma-in-mice-by-activating-t-lymphocytes
#7
Min Zhang, Yang Liu, Jingwen Li, Mengyun Ke, Jie Yu, Jie Dou, Hui Wang, Changlin Zhou
A component purified from Strongylocentrotus nudus eggs on a diethylaminoethyl cellulose-52 chromatography column and eluted using a NaCl solution gradient (SEP-S), is a homogeneous polysaccharide of α-D-glucan with a reduced molecular weight of 9.33×10(5) Da, compared with that of S. nudus egg polysaccharide (SEP). In an in vivo antitumor assay of histocompatibility-22 hepatocellular carcinoma in tumor-bearing mice, the inhibitory rates at SEP-S doses of 5, 10 and 20 mg/kg/day were 38.8, 50.7 and 70.3%, respectively...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454323/microrna-29a-b-c-targets-inos-and-is-involved-in-protective-remote-ischemic-preconditioning-in-an-ischemia-reperfusion-rat-model-of-non-alcoholic-fatty-liver-disease
#8
Yun-Fei Duan, Dong-Lin Sun, Jing Chen, Feng Zhu, Yong An
Remote ischemic preconditioning (RIPC) protects against the injury that is incurred by ischemia and reperfusion (IR); however, the role of RIPC in liver IR injury in non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, a NAFLD rat model was utilized in a series of different surgical procedures and molecular experiments. Rats of the IR group and the RIPC+IR group exhibited more severe injury than NAFLD control rats (in which the liver was prodded following a median-incision laparotomy). The liver condition, measured by serum alanine transaminase and aspartate transaminase levels, of the RIPC+IR group was better than that of the IR group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454310/downregulation-of-lkb1-promotes-tumor-progression-and-predicts-unfavorable-prognosis-in-patients-with-glioma
#9
Jiehao Huang, Hongwu Chen, Quantang Wei, Ziheng Zhang, Zhiwei Zhong, Yimin Xu
The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were performed. The present study demonstrated that LKB1 expression was markedly decreased at the messenger RNA and protein levels in 30 freshly prepared glioma tissues, compared with non-neoplastic brain tissues (P<0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454287/smad3-mutant-mice-develop-colon-cancer-with-overexpression-of-cox-2
#10
Yu-Ping Zhu, Zhuo Liu, Zhi-Xuan Fu, De-Chuan Li
Colon cancer is the second most common cause of cancer-associated mortality in human populations. The aim of the present study was to identify the role of cyclooxygenase-2 (COX-2) in Smad3 mutant mice, which are known to develop colon cancer. Homozygous Smad3 (-/-) mutant mice were generated from inbred and hybrid Smad3 mouse strains by intercrossing the appropriate heterozygotes. Immunohistochemistry with COX-2 antibody was performed throughout this experiment and the data was validated and cross-checked with reverse transcription-polymerase chain reaction (RT-PCR)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454241/transthyretin-regulates-the-migration-and-invasion-of-jeg-3-cells
#11
Liyun Gong, Lei Zhu, Shuzhen Wang, Zhenyu Zhang
Preeclampsia (PE) is a pregnancy-specific disorder characterized by new-onset hypertension and proteinuria that occurs after 20 weeks of gestation. It involves several organs and continues to be a leading cause of maternal and perinatal morbidity and mortality worldwide. Shallow trophoblast invasion is a common pathological feature of PE. Transthyretin (TTR) is a 56-kDa homotetrameric protein that binds thyroid hormone and retinol binding protein. Dysregulated TTR expression has been found in cases of PE. The aim of the present study was to determine the functional role of TTR in the migration and invasion of JEG-3 choriocarcinoma cells...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454228/prognostic-factors-of-long-term-outcome-in-surgically-resectable-pancreatic-neuroendocrine-tumors-a-12-year-experience-from-a-single-center
#12
Bo Zhou, Jixuan Duan, Sheng Yan, Jie Zhou, Shusen Zheng
The present study was performed to assess the prognostic factors with respect to patient survival and clinicopathological characteristics for patients who underwent surgery for pancreatic neuroendocrine tumors (PNETs). A retrospective review of patients pathologically diagnosed with PNETs at the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, Zhejiang, China) between September 2002 and September 2013 was conducted. The clinicopathological findings, overall survival (OS) rate and disease-free survival (DFS) rate of the patients with PNETs were analyzed...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454193/-mental-stress-of-professionals-in-residential-care-for-children-and-adolescents
#13
Thea Rau, Jeannine Ohlert, Corinna Seidler, Jörg M Fegert, Marc Allroggen
An increasingly important issue is the mental strain of professionals in residential care for children and adolescents. However, only few studies investigate mental strain and overload of professionals in an educational context in general and even less in youth welfare institutions. The goal of this study was to examine mental strain experiences of professionals with the "Perceived Stress Questionnaire" (PSQ) in youth welfare institutions, as well as to investigate the relationship between age, duration of employment in this work environment and gender of participants...
April 28, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28454191/-distress-main-burdens-engagement-motivators-and-needs-of-fulltime-and-volunteer-refugee-aid-workers
#14
Theresa Grimm, Ekaterini Georgiadou, Andrea Silbermann, Katharina Junker, Winfried Nisslbeck, Yesim Erim
In the psychosomatic department of the University Hospital of Erlangen trainings were conducted for active refugee aid workers with start in January, 2016. Meanwhile 49 helpers participated in the training and 45 of them filled out a survey questionnaire. Perceived distress when providing care for refugees, as well as engagement motivation and further training needs were explored. Furthermore, depressive symptoms as well as the prevalence of traumatic experiences were investigated. The main burden was experienced through lacking freedom of action on the background of legal regulations...
April 28, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28454184/-register-of-difficult-surgical-situations
#15
Michael Korenkov, Henning Dralle, Ernst Klar, Stefan Saad, Norbert Senninger, Jens Standop, Albrecht Stier, Martin Strik, Alexis Ulrich, Rudolf Weiner
Every surgical problem that increases the likelihood of intraoperative and postoperative complications is considered to be a difficult surgical situation. Based on this definition, Korenkov et al. proposed to classify patients according to the following intraoperative difficulty levels (I to IV): (I) ideal situation (easy to operate, no problems), (II) fairly easy/manageable/simple (some minor difficulties may occur), (III) difficult/problematic (difficult to operate; some operative techniques are considerably more difficult than others), and (IV) very difficult (every operative step is difficult/challenging)...
April 28, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28454160/spectral-selectivity-in-optical-fiber-capillary-dye-lasers
#16
Esmaeil Mobini, Behnam Abaie, Mostafa Peysokhan, Arash Mafi
We explore the spectral properties of a capillary dye laser in the highly multimode regime. Our experiments indicate that the spectral behavior of the laser does not conform to a simple Fabry-Perot (FP) analysis; rather, it is strongly dictated by a Vernier resonant mechanism involving multiple modes, which propagate with different group velocities. The laser operates over a very broad spectral range and the Vernier effect gives rise to a free spectral range, which is orders of magnitude larger than that expected from a simple FP mechanism...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454145/yb-sup-3-sup-doped-caf-sub-2-sub-laf-sub-3-sub-ceramics-laser
#17
Shotaro Kitajima, Kentaro Yamakado, Akira Shirakawa, Ken-Ichi Ueda, Yoshinobu Ezura, Hitoshi Ishizawa
Highly transparent ceramic is an attractive gain medium for high-power lasers due to its high fracture toughness, homogeneity, and size scalability. Here we report the first Yb<sup>3+</sup>-doped CaF<sub>2</sub>-LaF<sub>3</sub> ceramics laser. Codoping of La<sup>3+</sup> ion can reduce the formation of Yb<sup>2+</sup> ions and enhance the laser efficiency. In the laser experiment, the maximum output power of 4.36 W and the maximum slope efficiency of 69...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454128/2-3-%C3%AE-m-tm-sup-3-sup-ylf-laser-passively-q-switched-with-a-cr-sup-2-sup-znse-saturable-absorber
#18
Ferda Canbaz, Ismail Yorulmaz, Alphan Sennaroglu
We report, what is to our knowledge, the first passively Q-switched operation of a 2.3-μm Tm<sup>3+</sup>:YLF laser by using a Cr<sup>2+</sup>:ZnSe saturable absorber. In the experiments, a tunable Ti<sup>3+</sup>:sapphire laser was used to end pump the Tm<sup>3+</sup>:YLF gain medium inside an x cavity. A Cr<sup>2+</sup>:ZnSe saturable absorber was also included in the cavity to initiate passive Q switching. At all pump power levels above lasing threshold, passively Q-switched operation of the Tm<sup>3+</sup>:YLF laser could be obtained at 2309 nm with pulse durations and repetition frequencies in the ranges of 1...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454127/sn-based-waveguide-p-i-n-photodetector-with-strained-gesn-ge-multiple-quantum-well-active-layer
#19
Yu-Hui Huang, Guo-En Chang, Hui Li, H H Cheng
We report on Sn-based p-i-n waveguide photodetectors (WGPD) with a pseudomorphic GeSn/Ge multiple-quantum-well (MQW) active layer on a Ge-buffered Si substrate. A reduced dark-current density of 59  mA/cm<sup>2</sup> was obtained at a reverse bias of 1 V due to the suppressed strain relaxation in the GeSn/Ge active layer. Responsivity experiments revealed an extended photodetection range covering the O, E, S, C, and L telecommunication bands completely due to the bandgap reduction resulting from Sn-alloying...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454099/homoharringtonine-targets-smad3-and-tgf-%C3%AE-pathway-to-inhibit-the-proliferation-of-acute-myeloid-leukemia-cells
#20
Jian Chen, Qitian Mu, Xia Li, Xiufeng Yin, Mengxia Yu, Jing Jin, Chenying Li, Yile Zhou, Jiani Zhou, Shanshan Suo, Demin Lu, Jie Jin
Homoharringtonine (HHT) has long and widely been used in China for the treatment of acute myeloid leukemia (AML), the clinical therapeutic effect is significant but the working mechanism is poorly understood. The purpose of this study is to screen the possible target for HHT with virtual screening and verify the findings by cell experiments. Software including Autodock, Python, and MGL tools were used, with HHT being the ligand and proteins from PI3K-Akt pathway, Jak-stat pathway, TGF-β pathway and NK-κB pathway as the receptors...
April 8, 2017: Oncotarget
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