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Lauren R Borchers, Lisa Bruckert, Cory K Dodson, Katherine E Travis, Virginia A Marchman, Michal Ben-Shachar, Heidi M Feldman
Microstructural properties of white matter pathways are associated with concurrent reading abilities in children. In this longitudinal study, we asked whether properties of white matter pathways at the onset of learning to read would be associated with reading abilities at older ages. Children (N = 37) with a wide range of reading abilities completed standardized measures of language and phonological awareness and diffusion MRI at age 6 years. Mean tract-fractional anisotropy (FA) was extracted from reading-related pathways...
December 11, 2018: Brain Structure & Function
William Cory Ellis, Michal Schafer, Cindy S Barrett, Katie Butler, Andrew Sprowell, Mark Twite, Shannon Buckvold, Pei-Ni Jone, Richard J Ing
The correct selection and placement of a single-site Avalon® Elite Dual Lumen Cannula for veno-venous extracorporeal membrane oxygenation (ECMO) in children weighing less than 20 kg is dependent on both the mechanical characteristics of the catheter, including length and diameter, as well as the unique vascular anatomic considerations of the patient. This manuscript describes the development of a clinical strategy, over a four-year period from 2012-2016, for cannula selection to reduce the risk of migration and malposition in 20 critically ill children weighing less than 20 kg who presented for veno-venous ECMO...
December 11, 2018: Perfusion
Amanda Balboni Iniguez, Gabriela Alexe, Emily Jue Wang, Giovanni Roti, Sarvagna Patel, Liying Chen, Samuel Kitara, Amy Conway, Amanda L Robichaud, Björn Stolte, Pratiti Bandopadhayay, Amy Goodale, Sasha Pantel, Yenarae Lee, Dorian M Cheff, Matthew D Hall, Rajarshi Guha, Mindy I Davis, Marie Menard, Nicole Nasholm, William A Weiss, Jun Qi, Rameen Beroukhim, Federica Piccioni, Cory Johannessen, Kimberly Stegmaier
Drug resistance represents a major challenge to achieving durable responses to cancer therapeutics. Resistance mechanisms to epigenetically targeted drugs remain largely unexplored. We used bromodomain and extra-terminal domain (BET) inhibition in neuroblastoma as a prototype to model resistance to chromatin modulatory therapeutics. Genome-scale, pooled lentiviral open reading frame (ORF) and CRISPR knockout rescue screens nominated the phosphatidylinositol 3-kinase (PI3K) pathway as promoting resistance to BET inhibition...
December 10, 2018: Cancer Cell
Dhvani Shah, Nancy A Risebrough, Johnna Perdrizet, Neeraj N Iyer, Cory Gamble, Tam Dang-Tan
Background: The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcomes Results (LEADER) clinical trial demonstrated that liraglutide added to standard-of-care (SoC) therapy for type 2 diabetes (T2D) with established cardiovascular disease (CVD) or elevated cardiovascular (CV) risk was associated with lower rates of death from CVD, nonfatal myocardial infarction (MI), or nonfatal stroke than SoC alone. Objective: The objective of this study was to assess the cost-effectiveness (CE) and budget impact of liraglutide vs SoC in T2D patients with established CVD or elevated CV risk, over a lifetime horizon from a US managed care perspective...
2018: ClinicoEconomics and Outcomes Research: CEOR
Zhe Li, Liang Yu, Cory Milligan, Tao Ma, Lin Zhou, Yanran Cui, Zhiyuan Qi, Nicole Libretto, Biao Xu, Junwei Luo, Enzheng Shi, Zhenwei Wu, Hongliang Xin, W Nicholas Delgass, Jeffrey T Miller, Yue Wu
Supported nanoparticles are broadly employed in industrial catalytic processes, where the active sites can be tuned by metal-support interactions (MSIs). Although it is well accepted that supports can modify the chemistry of metal nanoparticles, systematic utilization of MSIs for achieving desired catalytic performance is still challenging. The developments of supports with appropriate chemical properties and identification of the resulting active sites are the main barriers. Here, we develop two-dimensional transition metal carbides (MXenes) supported platinum as efficient catalysts for light alkane dehydrogenations...
December 10, 2018: Nature Communications
Katharina Kitzinger, Cory C Padilla, Hannah K Marchant, Philipp F Hach, Craig W Herbold, Abiel T Kidane, Martin Könneke, Sten Littmann, Maria Mooshammer, Jutta Niggemann, Sandra Petrov, Andreas Richter, Frank J Stewart, Michael Wagner, Marcel M M Kuypers, Laura A Bristow
Ammonia-oxidizing archaea of the phylum Thaumarchaeota are among the most abundant marine microorganisms1 . These organisms thrive in the oceans despite ammonium being present at low nanomolar concentrations2,3 . Some Thaumarchaeota isolates have been shown to utilize urea and cyanate as energy and N sources through intracellular conversion to ammonium4-6 . Yet, it is unclear whether patterns observed in culture extend to marine Thaumarchaeota, and whether Thaumarchaeota in the ocean directly utilize urea and cyanate or rely on co-occurring microorganisms to break these substrates down to ammonium...
December 10, 2018: Nature Microbiology
Maj Cory J Darrow, Hong Li, Allison Prince, Jacquelyn McClary, Michele C Walsh
OBJECTIVE: Poor extrauterine growth in very low birth weight (VLBW) neonates is common and associated with worsened long-term outcomes. We aimed to decrease growth restriction, measured by the change in weight z-score from birth to 36 weeks post menstrual age, from - 1.13 (baseline) to < -1 within 12 months. STUDY DESIGN: The Model for Improvement was used in the design and implementation of an optimized, standardized parenteral nutrition protocol. Three Plan-Do-Study-Act cycles were completed and a [Formula: see text] and S control chart was created for the primary outcome...
December 7, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Cory M Resnick, Alfonso Salcines, Christopher D Hughes, Bonnie L Padwa, John B Mulliken
BACKGROUND: Patients with syndromic craniosynostosis exhibit exorbitism due to supraorbital and midfacial retrusion. This study documented the change in sagittal orbital-globe relationship following Le Fort III midfacial advancement. METHODS: This retrospective case series comprised patients with syndromic craniosynostosis who underwent midfacial distraction from 1997 to 2016. Changes in sagittal globe position in relation to the orbital rims were measured by pre- and postoperative direct anthropometry, computed tomographic scans, or both methods...
December 10, 2018: Journal of Craniofacial Surgery
Kyle Runckel, Matthew J Barth, Cory Mavis, Juan J Gu, Francisco J Hernandez-Ilizaliturri
Clinical observations suggest the existence of shared resistance pathways between rituximab and chemotherapy agents. To explore the mechanisms of rituximab resistance, our group created rituximab-resistant cell lines (RRCLs), which display altered expression of several inhibitor of apoptosis (IAP) family proteins. Here, we provide evidence to support pharmacologically targeting IAPs in lymphoma with LCL-161, a small molecule mimetic of the second mitochondria-derived activator of caspases (SMAC). The antitumor effect of LCL-161 was determined using luminescent adenosine triphosphate assays, flow cytometry, SCID mouse xenografts, and ex vivo patient biopsy sample studies...
December 11, 2018: Blood Advances
Scott M Lippman, Cory Abate-Shen, Karen L Colbert Maresso, Graham A Colditz, Andrew J Dannenberg, Nancy E Davidson, Mary L Disis, Raymond N DuBois, Eva Szabo, Anna R Giuliano, William N Hait, J Jack Lee, Thomas W Kensler, Barnett S Kramer, Paul Limburg, Anirban Maitra, Maria Elena Martinez, Timothy R Rebbeck, Kathryn H Schmitz, Eduardo Vilar, Ernest T Hawk
The recent pace, extent, and impact of paradigm-changing cancer prevention science has been remarkable. The American Association for Cancer Research (AACR) convened a 3-day summit, aligned with five research priorities: (i) Precancer Atlas (PCA). (ii) Cancer interception. (iii) Obesity-cancer linkage, a global epidemic of chronic low-grade inflammation. (iv) Implementation science. (v) Cancer disparities. Aligned with these priorities, AACR co-led the Lancet Commission to formally endorse and accelerate the NCI Cancer Moonshot program, facilitating new global collaborative efforts in cancer control...
December 2018: Cancer Prevention Research
Kelly Powers, Elizabeth K Herron, Cory Sheeler, Amber Sain
BACKGROUND: Despite the need to improve gender diversity in the United States nursing workforce, limited studies have explored the experience of former male nursing students and research is needed to provide guidance about teaching and mentoring strategies that can promote male student retention and success. PURPOSE: This study was conducted to explore the lived experience of former male nursing students. METHODS: A descriptive phenomenological approach was used...
November 2018: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
Jasmin Kuratli, Theresa Pesch, Hanna Marti, Cory Ann Leonard, Christian Blenn, Paul Torgerson, Nicole Borel
Chlamydia trachomatis is the major cause of infectious blindness and represents the most common bacterial sexually transmitted infection worldwide. Considering the potential side effects of antibiotic therapy and increasing threat of antibiotic resistance, alternative therapeutic strategies are needed. Previous studies showed that water filtered infrared A alone (wIRA) or in combination with visible light (wIRA/VIS) reduced C. trachomatis infectivity. Furthermore, wIRA/VIS irradiation led to secretion of pro-inflammatory cytokines similar to that observed upon C...
2018: Frontiers in Microbiology
Francis E Marchlinski, Cory M Tschabrunn
No abstract text is available yet for this article.
December 11, 2018: Journal of the American College of Cardiology
Cory R Woodyatt
No abstract text is available yet for this article.
December 2018: Annals of Epidemiology
Luz M Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A Jiménez-Sousa, Yolanda M Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M Benito, Norma Rallón, Salvador Resino
BACKGROUND: The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. METHODS: This is a retrospective study of 324 naïve cART patients with CD4+ < 200 cells/mm3 , who were followed-up during 24 months after initiating cART...
December 6, 2018: Journal of Translational Medicine
Alyaa Al-Ibraheemi, Cory Broehm, Munir R Tanas, Andrew E Horvai, Brian P Rubin, Alison L Cheah, Khin Thway, Cyril Fisher, Armita Bahrami, Andrew L Folpe, Karen J Fritchie
OBJECTIVES: Desmoplastic small round cell tumor (DSRCT) is an aggressive round cell sarcoma that arises in the abdominal cavity/pelvis of young males. We sought to expand its clinicopathologic spectrum. METHODS: Cases of DSRCT presenting in patients >30 years of age or tumors arising outside of the abdominal cavity/pelvis were retrieved. RESULTS: Thirty-four cases were identified. Sixteen tumors arose at atypical sites (head/neck, intracranial, thigh, axilla/shoulder, inguinal/paratesticular, intraosseous, and uterine corpus)...
December 6, 2018: International Journal of Surgical Pathology
Alireza Hassanshahi, Mohammadhossein Hassanshahi, Samira Khabbazi, Zahra Hosseini-Khah, Yaser Peymanfar, Saman Qhalamkari, Yu-Wen Su, Cory J Xian
Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose-derived stem cells (ASCs) seem to possess the least limitations for clinical applications, and literature showed that ASCs can improve the process of wound healing very likely by promoting angiogenesis and/or vascularisation, modulating immune response, and inducing epithelialization in the wound...
December 4, 2018: Journal of Cellular Physiology
Eric Vc Schneider, Caleb T Hasler, Cory D Suski
Deterring the spread of invasive fishes is a challenge for managers, and bigheaded carp (including bighead and silver carp, Hypophthalmichthys spp.) are invasive fish that have spread throughout large portions of the Mississippi River basin and threaten to invade the Great Lakes' ecosystem. Studies have shown that elevated levels of carbon dioxide gas (CO2 ) have the ability to act as a nonphysical fish barrier, but little work has been done on the efficacy of CO2 to deter fish movement in flowing water. An annular swim flume was used to measure Uburst and sprint duration of the model species largemouth bass (Micropterus salmoides) across a range of pCO2 levels (< 400 μatm [ambient]; 10,000 μatm; 50,000 μatm; and 100,000 μatm)...
December 4, 2018: Environmental Science and Pollution Research International
Anita Pokorny, Jaclyn Boyle, Alexander Hoffman, Cory P Coffey, Stacey Schneider
BACKGROUND AND PURPOSE: To describe and assess a longitudinal Professional Identity Development (PID) curriculum at Northeast Ohio Medical Universities (NEOMED) College of Pharmacy. EDUCATIONAL ACTIVITY AND SETTING: Northeast Ohio Medical University, a four-year professional program, has assimilated its career development and advising program into the curriculum as a primary element of the Pharmacist Patient Care Experience (PPCE) course. The concept of PID focuses on student pharmacist career development...
November 2018: Currents in Pharmacy Teaching & Learning
Cori Bussolari, Janice M Habarth, Sharleen Phillips, Rachel Katz, Wendy Packman
This study investigated self-compassion in the context of grief following the death of a companion animal in a recently bereaved sample ( N = 431). We addressed social contexts and individual differences focusing on how psychosocial outcomes vary as a function of social constraints, as well as individual differences in self-compassion and use of continuing bonds (CB). We observed that self-compassion related to the frequency of engagement in CB. Self-compassion also moderated relationships between grief severity and depression as well as social constraints and depression...
December 4, 2018: Omega
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