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Pejma Shazadeh Safavi, Cory Janney, Daniel Jupiter, Daniel Kunzler, Roger Bui, Vinod K Panchbhavi
BACKGROUND: The goal of this systematic review is to determine the most commonly used outcome measurement tools used by foot and ankle specialists and determine their limitations, such as whether they are validated, have floor/ceiling effects, and so on. METHODS: A literature search was conducted to identify primary publications between January 1, 2012 and July 1, 2017 that concern care of the foot and ankle and use any established grading criteria to evaluate patients...
October 19, 2018: Foot & Ankle Specialist
Carl Pellerin, Vinod Panchbhavi, Cory F Janney
Introduction Orthopaedic devices represent 12% of all medical device recalls. Products are approved through pre-market approval (PMA) or the 510(k) premarket notification process. No previous evaluation was found in the literature evaluating foot and ankle device recalls. The field of foot and ankle subspecialty has seen a rapid growth in innovation related to implants in recent years. Methods The Food and Drug Administration (FDA) Device Recall database was evaluated for all foot and ankle devices from 2007 through 2017 for the manufacturer, process of approval, type of implant, recall class, dates of initiation and termination of the recall, manufacturer determined reason, quantity affected, and distribution within the United States or internationally...
August 9, 2018: Curēus
Settimio Pacelli, Sayantani Basu, Cory Berkland, Jinxi Wang, Arghya Paul
Introduction: Physical and mechanical properties of ceramic-based scaffolds can be modulated by introducing hydrogel coatings on their surface. For instance, hydrogels can be used as elastic layers to overcome the brittleness of synthetic ceramic materials or to control the delivery of essential osteogenic factors. In this work, we aimed to achieve both goals by fabricating a novel cytocompatible hydrogel made of gelatin-alginate as a coating for beta-tricalcium phosphate (β-TCP) scaffolds...
June 2018: Cellular and Molecular Bioengineering
Chad E Songy, Cory G Couch, Eric R Siegel, James R Kee, Shahryar Ahmadi
BACKGROUND: The purpose of this study is to investigate how different diameters of radial head replacement affect posterolateral translation with a valgus and supination force. We hypothesized that there would be less posterolateral rotatory translation with larger implant diameter. METHODS: Eleven cadaveric arms were stressed at 30 and 60° of flexion with a consistent supination and valgus stress force under five conditions: native radial head, radial head excision, and with 3 sizes of radial head prosthesis...
October 4, 2018: Clinical Biomechanics
Rachel Wallwork, Zachary Wallace, Cory Perugino, Amita Sharma, John H Stone
Retroperitoneal fibrosis (RPF) refers to a fibro-inflammatory lesion in the retroperitoneum, often anterolateral to the aorta. Most cases are due to IgG4-related disease (IgG4-RD) or are idiopathic. RPF can lead to severe morbidity. Treatment strategies remain poorly-defined. We evaluated the efficacy and safety of rituximab (RTX) for idiopathic or IgG4-related RPF.We retrospectively reviewed the records of patients who had RPF treated with RTX. Treatment response was determined by assessing changes in both clinical features, including symptoms and laboratory measurements, as well as in the radiographic dimensions of the lesion...
October 2018: Medicine (Baltimore)
Dominic Keating, Gautham Marigowda, Lucy Burr, Cori Daines, Marcus A Mall, Edward F McKone, Bonnie W Ramsey, Steven M Rowe, Laura A Sass, Elizabeth Tullis, Charlotte M McKee, Samuel M Moskowitz, Sarah Robertson, Jessica Savage, Christopher Simard, Fredrick Van Goor, David Waltz, Fengjuan Xuan, Tim Young, Jennifer L Taylor-Cousar
BACKGROUND: VX-445 is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore Phe508del CFTR protein function in patients with cystic fibrosis when administered with tezacaftor and ivacaftor (VX-445-tezacaftor-ivacaftor). METHODS: We evaluated the effects of VX-445-tezacaftor-ivacaftor on Phe508del CFTR protein processing, trafficking, and chloride transport in human bronchial epithelial cells. On the basis of in vitro activity, a randomized, placebo-controlled, double-blind, dose-ranging, phase 2 trial was conducted to evaluate oral VX-445-tezacaftor-ivacaftor in patients heterozygous for the Phe508del CFTR mutation and a minimal-function mutation (Phe508del-MF) and in patients homozygous for the Phe508del CFTR mutation (Phe508del-Phe508del) after tezacaftor-ivacaftor run-in...
October 18, 2018: New England Journal of Medicine
Paul W Kline, Edward L Melanson, William J Sullivan, Patrick J Blatchford, Matthew J Miller, Jennifer E Stevens-Lapsley, Cory L Christiansen
Background: Physical activity remains low and nearly unchanged from pre-operative levels following total knee arthroplasty (TKA) and is a proposed problem underlying long-term functional limitations, secondary health problems, and higher healthcare costs after TKA. Objective: The objective is to determine whether a telehealth-based physical activity behavior-change intervention improves physical activity behavior and functional outcomes after TKA. Design: The design is a two-arm, parallel, assessor-blinded, RCT with baseline, mid-intervention, post-intervention, and 6-month follow-up assessments...
October 17, 2018: Physical Therapy
Cory R Schaffhausen, Marilyn J Bruin, Sauman Chu, Andrew Wey, Jon J Snyder, Bertram L Kasiske, Ajay K Israni
The Scientific Registry of Transplant Recipients (SRTR) provides federally mandated program-specific transplant data to the public. Currently, there is little understanding of how different program measures are prioritized by patients in selecting a program for transplantation. This study recruited 479 transplant advocacy group members from mailing lists and social media of the National Kidney Foundation (NKF), Transplant Families (TF), and Transplant Recipient International Organization (TRIO). Survey participants identified how many different programs would be reasonable to consider and viewed 4 measures that have recently been displayed on SRTR public search results websites and 6 measures not recently displayed and indicated importance on a 5-point scale...
October 16, 2018: Clinical Transplantation
Cory M McLaughlin, Minna M Wieck, Erica N Barin, Alyssa Rake, Rita V Burke, Heather B Roesly, L Caulette Young, Todd P Chang, Elizabeth A Cleek, Inge Morton, Catherine J Goodhue, Randall S Burd, Henri R Ford, Jeffrey S Upperman, Aaron R Jensen
PURPOSE: Simulation-based training has the potential to improve team-based care. We hypothesized that implementation of an in situ multidisciplinary simulation-based training program would improve provider confidence in team-based management of severely injured pediatric trauma patients. METHODS: An in situ multidisciplinary pediatric trauma simulation-based training program with structured debriefing was implemented at a free-standing children's hospital. Trauma providers were anonymously surveyed 1 month before (pre-), 1 month after (post-), and 2 years after implementation...
October 15, 2018: Pediatric Surgery International
Li-Shan Huang, Deborah A Cory-Slechta, Christopher Cox, Sally W Thurston, Conrad F Shamlaye, Gene E Watson, Edwin van Wijngaarden, Grazyna Zareba, J J Strain, Gary J Myers, Philip W Davidson
Background: The Seychelles Child Development Study has been examining the relationship between prenatal methylmercury (MeHg) exposure from consuming fish during pregnancy and child development. This study re-analyzes seven outcomes in the 17 year Main Cohort data to determine if there are nonlinear or non-homogeneous (subgroup) associations that were not identified in the linear analysis. Methods: We adopted two statistical approaches. First, we carried out an additive nonlinear analysis assuming homogeneous prenatal MeHg-outcome relationships to explore overall associations...
April 2018: Stochastic Environmental Research and Risk Assessment: Research Journal
Rie Ernst, Jennifer Ogeer, Donald McCrann, Julie Cross, Marilyn Strong-Townsend, Hanne Friis, Michael Coyne, Celeste Clements, Corie Drake, Rachel Murphy
Kidney disease is common in companion animals, and traditionally diagnosed with serum creatinine concentration (sCr), blood urea nitrogen, and abnormal urinalysis findings. Symmetric dimethylarginine (SDMA) is a novel kidney biomarker that reflects glomerular filtration rate, increasing earlier than sCr with acute kidney injury and chronic kidney disease. This prospective study compared accuracy and precision of two commercial SDMA assays, the IDEXX SDMA Test and the DLD SDMA ELISA, relative to the established reference method, liquid chromatography/mass spectrometry (LC-MS)...
2018: PloS One
Liang Huang, Hongcheng Lin, Liang Kang, Pinzhu Huang, Jun Huang, Jinlin Cai, Zhenyu Xian, Peixuan Zhu, Meijin Huang, Liping Wang, Cory J Xian, Jianping Wang, Jianghui Dong
Long noncoding RNAs (lncRNAs) play a critical role in the initiation and progression of colorectal cancer (CRC), but little is known about the function of lncRNAs in the colorectal liver metastasis (CLM). This study was designed to identify specific lncRNAs correlating to liver metastasis of CRC, and to further assess their clinical value. Seventeen patients with primary CRC lesions, adjacent normal mucosa, and synchronous liver metastases lesions were divided into discovery set (six patients) and test set (11 patients)...
October 14, 2018: Journal of Cellular Physiology
Keith Morris-Schaffer, Marissa Sobolewski, Kevin Welle, Katherine Conrad, Min Yee, Michael A O'Reilly, Deborah A Cory-Slechta
Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air pollution relate to particle size and the ultrafine particulate component (<100 nm) is considered the most reactive. We previously reported neonatal mice exposed to hyperoxia (60% oxygen), mimicking preterm oxygen supplementation, for the first 4 days of life, followed by exposure to concentrated ambient ultrafine particles (CAPS) from postnatal day (PND) 4-7 and 10-13 exhibited deficits in acquisition of performance on a fixed interval (FI) schedule of reinforcement, a behavioral paradigm rewarding the first response at the end of a fixed interval of time...
October 11, 2018: Neurotoxicology and Teratology
Cory M Resnick, Carly E Calabrese, Rohit Sahdev, Bonnie L Padwa
PURPOSE: Tongue-lip adhesion (TLA) and mandibular distraction osteogenesis (MDO) are the most common operations for obstructive apnea (OA) in infants with Robin sequence (RS). The purpose of this study was to compare early outcomes of TLA and MDO on resolution of OA. MATERIALS AND METHODS: This is a retrospective cohort study of infants with RS treated with TLA or MDO from 2005 through 2018. To be included, patients had to have polysomnograms pre- and postoperatively unless intubated or tracheostomy dependent...
September 18, 2018: Journal of Oral and Maxillofacial Surgery
David M Habiel, Milena S Espindola, Chris Kitson, Anthony V Azzara, Ana Lucia Coelho, Barry Stripp, Cory M Hogaboam
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease, with unknown etiopathogenesis and suboptimal therapeutic options. Previous reports have shown that increased T-cell numbers and CD28null phenotype is predictive of prognosis in IPF, suggesting that these cells might have a role in this disease. Flow cytometric analysis of explanted lung cellular suspensions showed a significant increase in CD8+ CD28null T cells in IPF relative to normal lung explants. Transcriptomic analysis of CD3+ T cells isolated from IPF lung explants revealed a loss of CD28-transcript expression and elevation of pro-inflammatory cytokine expression in IPF relative to normal T cells...
October 12, 2018: Mucosal Immunology
Cory L Brooks, Martin A Rossotti, Kevin A Henry
Homodimeric antibodies devoid of light chains have evolved multiple times through convergent evolution, yet their specific immunological functions remain poorly understood. We survey the molecular and structural features of these antibodies, their immunological functions in host defense, and reflect on the long-standing question of the evolutionary forces driving their emergence.
October 9, 2018: Trends in Immunology
Corie Borchert, Allyson Berent, Chick Weisse
CASE DESCRIPTION A 7-year-old female domestic shorthair cat was referred for evaluation of azotemia and unilateral hydronephrosis. CLINICAL FINDINGS Abdominal ultrasonography revealed right-sided hydronephrosis and dilation of the proximal aspect of the ureter; the left kidney was small with irregular margins. A highly vascular, irregular retroperitoneal mass, not clearly associated with the ureteral obstruction, was also visualized. Surgical exploration confirmed a retroperitoneal mass involving the caudal mesenteric artery and both ureters, with hydroureter on the right side...
November 1, 2018: Journal of the American Veterinary Medical Association
Jeffrey Alent, Dusty Marie Narducci, Byron Moran, Eric Coris
Sternal fractures were first described in published literature in the 19th century as a complication of traumatic injury. Though sternal fracture and other sternal injuries have been described in trauma literature, there remains a paucity of literature with regards to sternal injury in sport. Sternal injury may include disruption at the body, manubrium and xiphoid process, or at associated sternoclavicular, manubriosternal, and xiphisternal joints. In the athlete it is imperative to evaluate sternal injury with consideration of potentially devastating cardiothoracic complications...
October 11, 2018: Sports Medicine
Brodie J Lewis, Cassandra L Hesse, Briana C Cook, Cory L Pedersen
Masculine overcompensation-a phenomenon where men react to masculinity threats by endorsing hypermasculine ideals-has been demonstrated among straight men but has yet to be examined among gay men. The current study therefore proposed to examine whether gay men overcompensate similarly to their straight counterparts by providing participants with randomized feedback that threatened their masculinity. Overcompensation was measured in 867 online respondents by administering a series of questionnaires regarding views of pornography, rape, sex roles, and political orientation...
October 11, 2018: Journal of Homosexuality
Jessica L Parsons, Stewart I Cameron, Cory S Harris, Myron L Smith
CONTEXT: Plants of the genus Echinacea (Asteraceae) are among the most popular herbal supplements on the market today. Recent studies indicate there are potential new applications and emerging markets for this natural health product (NHP). OBJECTIVE: This review aims to synthesize recent developments in Echinacea biotechnology and to identify promising applications for these advances in the industry. METHODS: A comprehensive survey of peer-reviewed publications was carried out, focusing on Echinacea biotechnology and impacts on phytochemistry...
December 2018: Pharmaceutical Biology
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