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Michael Guarnieri, Cory Brayton, Betty M Tyler
Animal models to study opiates are of growing interest. We have examined the short-term safety of buprenorphine implants in Fischer F344/NTac rats treated with excess doses of a cholesterol-triglyceride suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of analgesia for 3 days. Chemistry, hematology, coagulation, and urinalysis values with 2- to 10-fold excess doses of the drug-lipid suspension were within normal limits. Histopathology findings were unremarkable...
2018: Journal of Veterinary Medicine
Nádia Ghinelli Amôr, Carine Ervolino de Oliveira, Thaís Helena Gasparoto, Vanessa Garcia Vilas Boas, Graziela Perri, Ramon Kaneno, Vanessa Soares Lara, Gustavo Pompermaier Garlet, João Santana da Silva, Gislâine A Martins, Cory Hogaboam, Karen A Cavassani, Ana Paula Campanelli
Squamous cell carcinoma (SCC) is the second most common form of skin cancer and the mechanism(s) involved in the progression of this tumor are unknown. Increases in the expression of IL-33/ST2 axis components have been demonstrated to contribute to neoplastic transformation in several tumor models and interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Based on these observations, we sought to determine the role of the IL-33/ST2 pathway during the development of SCC...
July 20, 2018: Oncotarget
Tahzeeb Fatima, Cushla McKinney, Tanya J Major, Lisa K Stamp, Nicola Dalbeth, Cory Iverson, Tony R Merriman, Jeffrey N Miner
BACKGROUND: Ferritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this study was to further explore the relationship between iron/ferritin and urate/gout. METHODS: European (100 cases, 60 controls) and Polynesian (100 cases, 60 controls) New Zealand (NZ) males and 189 US male cases and 60 male controls participated. The 10,727 participants without gout were from the Jackson Heart (JHS; African American = 1260) and NHANES III (European = 5112; African American = 4355) studies...
August 15, 2018: Arthritis Research & Therapy
Miriam S Hohmann, David M Habiel, Ana L Coelho, Waldiceu A Verri, Cory M Hogaboam
While cellular senescence may be a protective mechanism in modulating proliferative capacity, fibroblast senescence is now recognized as a key pathogenic mechanism in Idiopathic Pulmonary Fibrosis (IPF). In aged mice, abundance and persistence of apoptosis-resistant senescent fibroblasts play a central role in non-resolving lung fibrosis after bleomycin challenge. Therefore, we investigated whether quercetin can restore the susceptibility of senescent IPF fibroblasts to pro-apoptotic stimuli and mitigate bleomycin-induced pulmonary fibrosis in aged mice...
August 15, 2018: American Journal of Respiratory Cell and Molecular Biology
Natasha Fillmore, Cory S Wagg, Liyan Zhang, Arata Fukushima, Gary D Lopaschuk
Recent studies have proposed that elevated branched-chain amino acids (BCAAs) may induce insulin resistance (IR) in muscle secondary to increased BCAA oxidation inhibiting glucose oxidation (GO) and fatty acid oxidation (FAO). However, BCAA oxidation rates have not been assessed in muscle IR and cardiac FAO rates are elevated in obesity-associated IR. We examined cardiac BCAA oxidation in mice fed a high fat diet (HFD) to induce IR to better understand the role of cardiac BCAA oxidation in cardiac IR. BCAA oxidation, GO, FAO, and glycolysis were measured in isolated working hearts from mice fed a low fat diet (LFD) or HFD for 10 wk...
August 14, 2018: American Journal of Physiology. Endocrinology and Metabolism
Suji Choi, Sang Ihn Han, Dongjun Jung, Hye Jin Hwang, Chaehong Lim, Soochan Bae, Ok Kyu Park, Cory M Tschabrunn, Mincheol Lee, Sun Youn Bae, Ji Woong Yu, Ji Ho Ryu, Sang-Woo Lee, Kyungpyo Park, Peter M Kang, Won Bo Lee, Reza Nezafat, Taeghwan Hyeon, Dae-Hyeong Kim
Wearable and implantable devices require conductive, stretchable and biocompatible materials. However, obtaining composites that simultaneously fulfil these requirements is challenging due to a trade-off between conductivity and stretchability. Here, we report on Ag-Au nanocomposites composed of ultralong gold-coated silver nanowires in an elastomeric block-copolymer matrix. Owing to the high aspect ratio and percolation network of the Ag-Au nanowires, the nanocomposites exhibit an optimized conductivity of 41,850 S cm-1 (maximum of 72,600 S cm-1 )...
August 13, 2018: Nature Nanotechnology
Andrew S Burns, Cory C Padilla, Zoe A Pratte, Kailen Gilde, Matthew Regensburger, Eric Hall, Alistair D M Dove, Frank J Stewart
Denitrification by sulfur-oxidizing bacteria is an effective nitrate removal strategy in engineered aquatic systems. However, the community taxonomic and metabolic diversity of sulfur-driven denitrification (SDN) systems, as well as the relationship between nitrate removal and SDN community structure, remains underexplored. This is particularly true for SDN reactors applied to marine aquaria, despite increasing use of this technology to supplement filtration. We applied 16S rRNA gene, metagenomic, and metatranscriptomic analysis to explore the microbial basis of SDN reactors operating on Georgia Aquarium's Ocean Voyager , the largest indoor closed-system seawater exhibit in the United States...
August 10, 2018: Applied and Environmental Microbiology
Dounia Daoud, Anne McCarthy, Cory Dubetz, Duane E Barker
This study examined the effects of a range of ½-log concentrations of emamectin benzoate (commercially applied as SLICE® ) and ivermectin (commercially applied as IVOMEC® ) on juvenile American lobster, Homarus americanus. Phase I of the research assessed acute (up to 4 days) and chronic (30-day) toxicity of sediment dosed with the active ingredients emamectin benzoate (EMB) formulated as SLICE® or ivermectin (IVM) formulated as IVOMEC® at various nominal concentrations (EMB: 15, 48, 150, 475 and 1500 ng g-1 wet sediment; IVM: 3, 9...
August 7, 2018: Ecotoxicology and Environmental Safety
Erica Ollmann Saphire, Sharon L Schendel, Marnie L Fusco, Karthik Gangavarapu, Bronwyn M Gunn, Anna Z Wec, Peter J Halfmann, Jennifer M Brannan, Andrew S Herbert, Xiangguo Qiu, Kshitij Wagh, Shihua He, Elena E Giorgi, James Theiler, Kathleen B J Pommert, Tyler B Krause, Hannah L Turner, Charles D Murin, Jesper Pallesen, Edgar Davidson, Rafi Ahmed, M Javad Aman, Alexander Bukreyev, Dennis R Burton, James E Crowe, Carl W Davis, George Georgiou, Florian Krammer, Christos A Kyratsous, Jonathan R Lai, Cory Nykiforuk, Michael H Pauly, Pramila Rijal, Ayato Takada, Alain R Townsend, Viktor Volchkov, Laura M Walker, Cheng-I Wang, Larry Zeitlin, Benjamin J Doranz, Andrew B Ward, Bette Korber, Gary P Kobinger, Kristian G Andersen, Yoshihiro Kawaoka, Galit Alter, Kartik Chandran, John M Dye
Antibodies are promising post-exposure therapies against emerging viruses, but which antibody features and in vitro assays best forecast protection are unclear. Our international consortium systematically evaluated antibodies against Ebola virus (EBOV) using multidisciplinary assays. For each antibody, we evaluated epitopes recognized on the viral surface glycoprotein (GP) and secreted glycoprotein (sGP), readouts of multiple neutralization assays, fraction of virions left un-neutralized, glycan structures, phagocytic and natural killer cell functions elicited, and in vivo protection in a mouse challenge model...
August 9, 2018: Cell
Michael T Archdeacon, Cory A Collinge, Adam P Schumaier, Georgina Glogovac
Pelvic fractures are common after high-energy trauma and are often associated with ligamentous injury. Treatment is guided by assessing stability of the pelvic ring, and unstable injuries frequently require surgery to achieve a desirable outcome. Assessment of pelvic ring stability is often possible with physical examination and standard imaging studies (plain radiographs and computed tomography); however, these "static" imaging modalities may not adequately identify dynamically unstable pelvic injuries that require surgery...
September 2018: Journal of Orthopaedic Trauma
Karen A Cavassani, Rebecca J Meza, David M Habiel, Jie-Fu Chen, Alexander Montes, Manisha Tripathi, Gislâine A Martins, Timothy R Crother, Sungyong You, Cory M Hogaboam, Neil Bhowmick, Edwin M Posadas
BACKGROUND: Recruited myeloid cells are known to promote cancer initiation, malignant progression, metastasis, and resistance to therapy in the tumor niche. We tested the hypothesis that circulating blood monocytes from advanced prostate cancer (PCa) patients exhibit a protumor phenotype and directly influence the tumor microenvironment in response to tumor-derived signals. METHODS: Blood monocytes from advanced and stable PCa patients were cultured, and the conditioned media (CM) were collected and analyzed using standard invasion and wound closure assays to measure effects on invasion and motility of PCa tumor cells...
August 9, 2018: Cancer Medicine
Neil S Kumar, Tiahna Spencer, Mark P Cote, Robert A Arciero, Cory Edgar
Background: Medial meniscal tears are commonly seen during anterior cruciate ligament reconstruction (ACLR). A subset of these injuries includes posterior meniscocapsular junction or "ramp" tears. One criterion that may correlate with a ramp lesion is the presence of posterior medial tibial plateau (PMTP) edema. Purpose: To compare patients with ramp lesions to patients with nonramp (meniscal body) medial meniscal tears and correlate PMTP edema on preoperative magnetic resonance imaging (MRI) to the incidence of ramp tears...
June 2018: Orthopaedic Journal of Sports Medicine
Romel Dator, Linda von Weymarn, Peter W Villalta, Cory J Hooyman, Laura A Maertens, Pramod Upadhyaya, Sharon Elizabeth Murphy, Silvia Balbo
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a potent lung carcinogen and exerts its carcinogen effects upon metabolic activation. The identification and quantitation of NNK metabolites could identify potential biomarkers of bio-activation and detoxification of this potent carcinogen and may be used to predict lung cancer susceptibility among smokers. Here, we have used in vivo isotope labeling and high-resolution mass spectrometry-based methods for the comprehensive profiling of all known and unknown NNK metabolites...
August 7, 2018: Analytical Chemistry
Cory Messerschmidt, Anuj Netto, William R Barfield, Christopher Gross, William McKibbin
The effects of gastrocnemius recession on strength and function are underreported. This prospective study reports strength and functional effects after isolated gastrocnemius recession. Patients (n D 20) underwent an isolated gastrocnemius recession for foot and ankle conditions with associated gastrocnemius or gastrocnemius-soleus contracture. Eight patients prospectively underwent range of motion (ROM) and Biodex testing preoperatively and at 3 and 6 months postoperatively. Foot Function Index (FFI) assessed functional outcomes...
2018: Journal of Surgical Orthopaedic Advances
Cory M Pfeifer
No abstract text is available yet for this article.
June 27, 2018: Current Problems in Diagnostic Radiology
Bertram L Kasiske, Andrew Wey, Nicholas Salkowski, David Zaun, Cory R Schaffhausen, Ajay K Israni, Jon J Snyder
The Scientific Registry of Transplant Recipients (SRTR) is mandated by the National Organ Transplant Act, the Final Rule, and the SRTR contract with the Health Resources and Services Administration to report program-specific information on the performance of transplant programs. Following a consensus conference in 2012, SRTR developed a new version of the public website to improve public reporting of often complex metrics, including changing from a 3-tier to a 5-tier summary metric for first-year posttransplant survival...
August 3, 2018: American Journal of Transplantation
Marissa Sobolewski, Garima Singh, Jay S Schneider, Deborah A Cory-Slechta
While it is clear that behavioral experience modulates epigenetic profiles, it is less evident how the nature of that experience influences outcomes and whether epigenetic/genetic "biomarkers" could be extracted to classify different types of behavioral experience. To begin to address this question, male and female mice were subjected to either a Fixed Interval (FI) schedule of food reward, or a single episode of forced swim followed by restraint stress, or no explicit behavioral experience after which global expression levels of two activating (H3K9ac and H3K4me3) and two repressive (H3K9me2 and H3k27me3) post-translational histone modifications (PTHMs), were measured in hippocampus (HIPP) and frontal cortex (FC)...
2018: Frontiers in Integrative Neuroscience
Yongfu Wang, Zulin Yu, Cori K Cahoon, Tari Parmely, Nancy Thomas, Jay R Unruh, Brian D Slaughter, R Scott Hawley
Biologists have long been fascinated with the organization and function of intricate protein complexes. Therefore, techniques for precisely imaging protein complexes and the location of proteins within these complexes are critically important and often require multidisciplinary collaboration. A challenge in these explorations is the limited resolution of conventional light microscopy. However, a new microscopic technique has circumvented this resolution limit by making the biological sample larger, thus allowing for super-resolution of the enlarged structure...
August 2, 2018: Nature Protocols
Alexander J Novarro, Caitlin R Gabor, Cory B Goff, Tori D Mezebish, Lily M Thompson, Kristine L Grayson
Widespread species often possess physiological mechanisms for coping with thermal heterogeneity, and uncovering these mechanisms provides insight into species responses to climate change. The emergence of non-invasive corticosterone (CORT) assays allows us to rapidly assess physiological responses to environmental change on a large scale. We lack, however, a basic understanding of how temperature affects CORT, and whether temperature and CORT interactively affect performance. Here, we examine the effects of elevated temperature on CORT and whole-organism performance in a terrestrial salamander, Plethodon cinereus, across a latitudinal gradient...
August 2, 2018: Journal of Experimental Biology
Yuan-Yuan Wang, Xiu-Ying Pu, Wen-Gui Shi, Qing-Qing Fang, Xin-Ru Chen, Hui-Rong Xi, Yu-Hai Gao, Jian Zhou, Cory J Xian, Ke-Ming Chen
The application of pulsed electromagnetic fields (PEMFs) in the prevention and treatment of osteoporosis has long been an area of interest. However, the clinical application of PEMFs remains limited because of the poor understanding of the PEMF action mechanism. Here, we report that PEMFs promote bone formation by activating soluble adenylyl cyclase (sAC), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), and cAMP response element-binding protein (CREB) signaling pathways. First, it was found that 50 Hz 0...
August 1, 2018: Journal of Cellular Physiology
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