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https://www.readbyqxmd.com/read/30317801/-clinical-significance-and-correlation-of-ductular-reaction-in-hepatobiliary-diseases
#1
Y J Zheng, M X Pan, Y Wang
Ductular reaction is a kind of repair response to biliary and hepatocellular injury, and the pathological changes include lobular bile duct hyperplasia, matrix change and inflammatory cell infiltrations. In human liver, a ductular reaction originates from the activation and proliferation of hepatic progenitor cells. The activated hepatic progenitor cells, the intermediate hepatocytes and the reactive small bile duct cells together form the cell complex of ductular reaction, which has the dual characteristics of hepatobiliary system and co-expresses the hepatocyte and cholangiocyte antigen...
August 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/30317030/stack-releases-of-radionuclides-from-an-integrated-steel-plant-in-china
#2
Jinfeng Li, Ziqiang Pan, Ziying Jiang, Senlin Liu, Chuangao Wang, Yanqi Zhang, Chunhong Wang, Ling Chen, Zhijun Huang, Jingshun Pan, Xutao Xu
Crude steel production in China made up the majority of the global output, at 49.5% in 2014. High temperature smelting processes result in the release of natural radionuclides, including radon gas and other air pollutants into the atmosphere. This paper conducts an analysis of the raw materials, end products and flue gas sampled from an integrated steel plant from within China's Jiangxi Province, with annual production of 8.50 Mt of crude steel. Normalized stack emissions factors of radionuclides from steel production were first reported in China...
October 11, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/30316952/laboratory-alerts-to-guide-early-intensive-care-team-review-in-surgical-patients-a-feasibility-safety-and-efficacy-pilot-randomized-controlled-trial
#3
Rinaldo Bellomo, Matthew Chan, Christopher Guy, Helena Proimos, Federica Franceschi, Marco Crisman, Aniket Nadkarni, Paolo Ancona, Kevin Pan, Francesca Di Muzio, Barbara Presello, James Bailey, Marcus Young, Graeme K Hart
AIM: Common blood tests can help identify patients at risk of death, unplanned intensive care unit (ICU) admission, or rapid response team (RRT) call. We aimed to test whether early ICU-team review triggered by such laboratory tests (lab alert) is feasible, safe, and can alter physiological variables, clinical management, and clinical outcomes. METHODS: In prospective pilot randomized controlled trial in surgical wards of a tertiary hospital, we studied patients admitted for > 24 hours...
October 11, 2018: Resuscitation
https://www.readbyqxmd.com/read/30316382/vacuum-sealing-drainage-therapy-for-refractory-infectious-wound-on-16-renal-transplant-recipients
#4
X Chen, L Liu, W Nie, R Deng, J Li, Q Fu, J Fei, C Wang
BACKGROUND: Refractory infectious wounds on renal transplantation (RT) recipients significantly prolong hospital stay, increase medical costs, and threaten allograft survival. Vacuum sealing drainage (VSD) therapy is a new technique for managing wounds based on the principle of application of controlled negative pressure. The aim of this study was to summarize the efficacy and safety of VSD therapy in the management of refractory infectious wounds following RT. MATERIALS AND METHODS: This is a retrospective study of a cohort of 661 consecutive patients who received renal transplants over a period of 3 years in which the data were collected and analyzed retrospectively...
October 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30315971/effect-of-bilateral-anterior-cingulotomy-on-chronic-neuropathic-pain-with-severe-depression
#5
Zhengdao Deng, Yixin Pan, Dianyou Li, Chencheng Zhang, Haiyan Jin, Tao Wang, Shikun Zhan, Bomin Sun
BACKGROUND: The presence of neuropathic pain can severely impinge on emotional regulation and activities of daily living, including social activities, resulting in diminished life satisfaction. Unfortunately, the majority of patients with neuropathic pain do not experience an amelioration of symptoms from conventional therapies, even when multimodal therapies are used. Chronic refractory neuropathic pain is usually accompanied by severe depression that is prone to incur suicidal events, thus clinical management of chronic neuropathic pain and depression presents a serious challenge for clinicians and patients...
October 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30315810/exploration-and-preparation-of-a-dose-flexible-regulation-system-for-levetiracetam-tablets-via-novel-semisolid-extrusion-sse-3d-printing
#6
Mengsuo Cui, Yuenan Li, Shu Wang, Yuanyuan Chai, Jintong Lou, Fen Chen, Qijun Li, Weisan Pan, Pingtian Ding
Levetiracetam therapy is often associated with high levels of individual variation in the recommended dose required to achieve preferential treatment. Thus, a reliable and dynamic regulation system to accurately tailor dose is necessary. The main objective of this work was to explore and prepare a dose-flexible control system suitable for rapid release tablets equipped with high drug loading and a cylindrical model design. Semisolid extrusion 3D printing was utilized to fabricate a series of tablets of increased volume...
October 10, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30315657/normal-human-skin-is-superior-to-monkey-esophagus-substrate-for-detection-of-circulating-bp180-nc16a-specific-immunoglobulin-g-antibodies-in-bullous-pemphigoid
#7
S Emtenani, H Yuan, C Lin, M Pan, J E Hundt, E Schmidt, L Komorowski, J R Stanley, C M Hammers
BACKGROUND: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering skin disease. Two antigens were identified as targets of circulating autoantibodies (abs), BP180 and BP230, with BP180 being a critical transmembrane adhesion protein of basal keratinocytes of the epidermis. The non-collagenous domain 16A (NC16A) of BP180 is the immunodominant epitope in BP patients, and anti-BP180-NC16A immunoglobulin G (IgG) abs correlate to disease activity. Routine serologic testing and follow-up of BP relies on indirect immunofluorescence (IIF) of serum abs, commonly performed on monkey esophagus (ME), and/or ELISA testing on recombinantly produced fragments of BP180 and BP230 (BP180-NC16A, BP230-C/N)...
October 13, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/30315621/insight-into-the-evolution-and-functional-characteristics-of-the-pan-genome-assembly-from-sesame-landraces-and-modern-cultivars
#8
Jingyin Yu, Agnieszka A Golicz, Kun Lu, Komivi Dossa, Yanxin Zhang, Jinfeng Chen, Linhai Wang, Jun You, Dingding Fan, David Edwards, Xiurong Zhang
Sesame (Sesamum indicum L.) is an important oil crop renowned for its high oil content and quality. Recently, genome assemblies for five sesame varieties including two landraces (S. indicum cv. Baizhima and Mishuozhima) and three modern cultivars (S. indicum var. Zhongzhi13, Yuzhi11 and Swetha), have become available providing a rich resource for comparative genomic analyses and gene discovery. Here, we employed a reference-assisted assembly approach to improve the draft assemblies of four of the sesame varieties...
October 13, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/30315525/irf-1-intervention-in-the-classical-ros-dependent-release-of-nets-during-lps-induced-acute-lung-injury-in-mice
#9
Shuai Liu, Yinyan Yue, Pinhua Pan, Lemeng Zhang, Xiaoli Su, Haitao Li, Haosi Li, Yi Li, Minhui Dai, Qian Li, Zhi Mao
Previously, we demonstrated that neutrophil extracellular traps (NETs) play an essential role in lipopolysaccharide (LPS)-induced acute lung injury. However, the underlying mechanism is unclear. In this study, we showed that knockout of interferon regulatory factor 1 (IRF-1) in mice strongly attenuated the generation of NETs and reactive oxygen species (ROS) production in neutrophils from bronchoalveolar lavage fluid and alleviated LPS-induced lung injury and systemic inflammation. Our in vitro experiments demonstrated that LPS-stimulated platelets induce NET release through two distinct processes: an ROS-independent early/rapid NETosis and a later ROS-dependent classical NETosis...
October 12, 2018: Inflammation
https://www.readbyqxmd.com/read/30315229/inhibitors-of-the-protein-disulfide-isomerase-family-for-the-treatment-of-multiple-myeloma
#10
Reeder M Robinson, Leticia Reyes, Ravyn M Duncan, Haiyan Bian, Allen B Reitz, Yefim Manevich, Jesse J McClure, Matthew M Champion, C James Chou, Meahgen E Sharik, Marta Chesi, P Leif Bergsagel, Nathan G Dolloff
Multiple Myeloma (MM) is highly sensitive to disruptions in cellular protein homeostasis. Proteasome inhibitors (PIs) are initially effective in the treatment of MM, although cures are not achievable and the emergence of resistance limits the durability of responses. New therapies are needed for refractory patients, and those that combat resistance to standard of care agents would be particularly valuable. Screening of multiple chemical libraries for PI re-sensitizing compounds identified E61 as a potent enhancer of multiple PIs and MM specific activity...
October 12, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/30315167/s-nitrosylation-of-the-zinc-finger-protein-srg1-regulates-plant-immunity
#11
Beimi Cui, Qiaona Pan, David Clarke, Marisol Ochoa Villarreal, Saima Umbreen, Bo Yuan, Weixing Shan, Jihong Jiang, Gary J Loake
Nitric oxide (NO) orchestrates a plethora of incongruent plant immune responses, including the reprograming of global gene expression. However, the cognate molecular mechanisms remain largely unknown. Here we show a zinc finger transcription factor (ZF-TF), SRG1, is a central target of NO bioactivity during plant immunity, where it functions as a positive regulator. NO accumulation promotes SRG1 expression and subsequently SRG1 occupies a repeated canonical sequence within target promoters. An EAR domain enables SRG1 to recruit the corepressor TOPLESS, suppressing target gene expression...
October 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/30314427/nonlinear-modeling-of-neural-interaction-for-spike-prediction-using-the-staged-point-process-model
#12
Cunle Qian, Xuyun Sun, Shaomin Zhang, Dong Xing, Hongbao Li, Xiaoxiang Zheng, Gang Pan, Yiwen Wang
Neurons communicate nonlinearly through spike activities. Generalized linear models (GLMs) describe spike activities with a cascade of a linear combination across inputs, a static nonlinear function, and an inhomogeneous Bernoulli or Poisson process, or Cox process if a self-history term is considered. This structure considers the output nonlinearity in spike generation but excludes the nonlinear interaction among input neurons. Recent studies extend GLMs by modeling the interaction among input neurons with a quadratic function, which considers the interaction between every pair of input spikes...
October 12, 2018: Neural Computation
https://www.readbyqxmd.com/read/30314339/strengthening-effects-of-zn-addition-on-an-ultrahigh-ductility-mg-gd-zr-magnesium-alloy
#13
Yaobo Hu, Chao Zhang, Tianxu Zheng, Fusheng Pan, Aitao Tang
A newly developed Mg-2Gd-0.5Zr- x Zn ( x = 0.5, 1.0, 2.0, 3.0 wt %) alloy system exhibits significant strengthening by doping with Zn. In order to understand the strengthening mechanism, the microstructure, texture evolution, and mechanical properties of ultrahigh ductility Mg-2Gd-0.5Zr alloys with a Zn addition were systematically investigated. The addition of Zn results in the formation of Mg-Gd-Zn intermetallic compounds along grain boundaries, which encourages grain refinement during hot extrusion via the particle stimulated nucleation (PSN) mechanism...
October 11, 2018: Materials
https://www.readbyqxmd.com/read/30314308/side-slither-data-based-vignetting-correction-of-high-resolution-spaceborne-camera-with-optical-focal-plane-assembly
#14
Chaochao Chen, Jun Pan, Mi Wang, Ying Zhu
Optical focal plane assemblies are increasingly being used in high-resolution optical satellite systems to enhance the width of the image using linear push-broom imaging. With this system, vignetting occurs in the area of overlap, affecting image quality. In this paper, using the characteristics of the side-slither data, we propose side-slither data-based vignetting correction of a high-resolution spaceborne camera with an optical focal plane assembly. First, the raw side-slither data standardization is used to ensure that each row has the same features...
October 11, 2018: Sensors
https://www.readbyqxmd.com/read/30314191/dolichopodidae-of-riverbeds-and-springs-in-croatia-with-an-updated-checklist-of-croatia-diptera
#15
Marc Pollet, Marija IvkoviĆ
Several invertebrate surveys in Croatia conducted between 2005 and 2014 and including; e.g., Plitvice Lakes, produced 123 bycatch samples of Dolichopodidae (Diptera) from 68 sampling sites collected at 36 localities in seven counties. Seventy-seven were retrieved from emergence traps, six from pan traps and 40 were collected with sweep net and/or aspirator. They contained 420 dolichopodid flies that belonged to 64 species in 22 genera. Four species, Campsicnemus umbripennis, Hercostomus chetifer, Liancalus virens and Syntormon pallipes, accounted for over half of the yields...
August 3, 2018: Zootaxa
https://www.readbyqxmd.com/read/30313075/efficacy-and-safety-of-nicotinamide-on-phosphorus-metabolism-in-hemodialysis-patients-a-systematic-review-and-meta-analysis
#16
Yong Zhang, Tean Ma, Pan Zhang
BACKGROUND: Recent evidence has shown that nicotinamide treatment may have an impact on phosphorus metabolism in hemodialysis patients. Nevertheless, the treatment remains controversial. This study aimed to precisely estimate the efficacy and safety of nicotinamide on phosphorus, calcium and iPTH in hemodialysis patients. METHODS: We searched numerous information sources regarding randomized controlled trials (RCTs) of nicotinamide treatment in hemodialysis patients, including PubMed, EMBASE, and the Cochrane Library...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312846/an-efficient-bivalent-cyclic-rgd-pik3cb-sirna-conjugate-for-specific-targeted-therapy-against-glioblastoma-in-vitro-and-in-vivo
#17
Bohong Cen, Yuanyi Wei, Wen Huang, Muzhou Teng, Shuai He, Jianlong Li, Wei Wang, Guolin He, Xin Bai, Xiaoxia Liu, Yawei Yuan, Xinghua Pan, Aimin Ji
The PI3K-AKT-mTOR-signaling pathway is frequently activated in glioblastoma (GBM). Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB)/p110β (a PI3K catalytic isoform) by RNAi substantially suppresses GBM growth with less toxicity to normal astrocytes. However, insufficient and non-specific small interfering RNA (siRNA) delivery may limit the efficacy of RNAi-based therapies against GBM. Here we prepared a novel methoxy-modified PIK3CB siRNA molecule (siPIK3CB) that was covalently conjugated to a [cyclo(Arg-Gly-Asp-D-Phe-Lys)-Ahx]2 -Glu-PEG-MAL (biRGD) peptide, which selectively binds to integrin αvβ3 receptors...
September 6, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30312729/pan-pim-kinase-inhibitors-enhance-lenalidomide-s-anti-myeloma-activity-via-cereblon-ikzf1-3-cascade
#18
Jing Zheng, Yonggang Sha, Logan Roof, Oded Foreman, John Lazarchick, Jagadish Kummetha Venkta, Cleopatra Kozlowski, Cristina Gasparetto, Nelson Chao, Allen Ebens, Jianda Hu, Yubin Kang
Multiple myeloma remains an incurable disease, and continued efforts are required to develop novel agents and novel drug combinations with more effective anti-myeloma activity. Here, we show that the pan-PIM kinase inhibitors SGI1776 and CX6258 exhibit significant anti-myeloma activity and that combining a pan-PIM kinase inhibitor with the immunomodulatory agent lenalidomide in an in vivo myeloma xenograft mouse model resulted in synergistic myeloma cell killing without additional hematologic or hepatic toxicities...
October 9, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30312435/comparative-transcriptome-analysis-of-poncirus-trifoliata-identifies-a-core-set-of-genes-involved-in-arbuscular-mycorrhizal-symbiosis
#19
Jianyong An, Mengqian Sun, Robin van Velzen, Chuanya Ji, Zijun Zheng, Erik Limpens, Ton Bisseling, Xiuxin Deng, Shunyuan Xiao, Zhiyong Pan
The perennial woody plants of citrus are one of the most important fruit crops in the world and largely depends on arbuscular mycorrhizal symbiosis (AMS) to obtain essential nutrients from soil. However, the molecular aspects of AMS in citrus and perennial woody plants in general have largely been understudied. We used RNA-sequencing to identify differentially expressed genes in roots of Poncirus trifoliata upon mycorrhization by the AM fungus Glomus versiforme and evaluated their conservation by comparative transcriptome analyses with four herbaceous model plants...
October 12, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/30312406/mammary-metabolism-and-colostrogenesis-in-sows-during-late-gestation-and-the-colostral-period
#20
Takele Feyera, Pan Zhou, Morakot Nuntapaitoon, Kristina Ulrich Sørensen, Uffe Krogh, Thomas Sønderby Bruun, Stig Purup, Henry Jørgensen, Hanne Damgaard Poulsen, Peter Kappel Theil
The aims of this study were to investigate 1) the effect of high dietary fiber (DF; 19.3 to 21.7%) supplemented to late gestating sows on mammary uptake and metabolism of energy substrates as well as colostrum production and 2) the ontogeny of colostral fat and lactose synthesis using mammary carbon balance, and colostral protein using IgG as a biomarker. Sows were fed either a control diet (CON) consisting of a standard gestation diet (14.6% DF) until d 108 of gestation and a transition diet (16.8% DF) from d 109 of gestation until farrowing or a high DF treatment where part of the daily ration was replaced with a high DF supplement (FIB)...
October 12, 2018: Journal of Animal Science
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