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https://www.readbyqxmd.com/read/30553203/urinary-levels-of-bisphenol-a-f-and-s-and-markers-of-oxidative-stress-among-healthy-adult-men-variability-and-association-analysis
#1
Yi-Xin Wang, Chong Liu, Ying Shen, Qi Wang, An Pan, Pan Yang, Ying-Jun Chen, Yan-Ling Deng, Qing Lu, Li-Ming Cheng, Xiao-Ping Miao, Shun-Qing Xu, Wen-Qing Lu, Qiang Zeng
BACKGROUND: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. OBJECTIVE: To evaluate the variability and associations of levels of BPA, BPS, BPF and 3 oxidative stress markers [i...
December 12, 2018: Environment International
https://www.readbyqxmd.com/read/30553153/housefly-larvae-musca-domestica-significantly-accelerates-degradation-of-monensin-by-altering-the-structure-and-abundance-of-the-associated-bacterial-community
#2
Hao Li, Qiang Wan, Shudong Zhang, Chuanwen Wang, Shanchun Su, Baoliang Pan
Vermicomposting of livestock manure using housefly larvae is a promising biotechnology for waste reduction and control of antibiotic pollution. Monensin (MON), an ionophore polyether antibiotic (IPA), is widely used in broiler feed to control coccidiosis. However, MON residues in litter have become a major source of pollution in the environment. In this work, we studied the efficiency of housefly larvae (Musca domestica) on monensin attenuation during a 12-day laboratory scale vermicomposting experiment. We observed a 94...
December 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30553143/synthesis-and-evaluation-of-clioquinol-rolipram-roflumilast-hybrids-as-multitarget-directed-ligands-for-the-treatment-of-alzheimer-s-disease
#3
Jinhui Hu, Tingting Pan, Baijiao An, Zhengcunxiao Li, Xingshu Li, Ling Huang
Considering the importance of PDE4D inhibition and the modulation of biometals in Alzheimer's disease (AD) therapeutics, we have designed, synthesized and evaluated a series of new clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of AD. In vitro studies demonstrated that some of the molecules processed remarkable inhibitory activity against phosphodiesterase 4D (PDE4D), strong intracellular antioxidant capacity, potent inhibition of metal-induced aggregation of Aβ, and potential blood-brain barrier permeability...
December 7, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30553058/enhancement-of-the-apparent-solubility-and-bioavailability-of-tadalafil-nanoparticles-via-antisolvent-precipitation
#4
Qiuhong Rao, Zhenwen Qiu, Deen Huang, Tiejun Lu, Zhenyu Jason Zhang, Dandong Luo, Piaopiao Pan, Lei Zhang, Yingyan Liu, Shixia Guan, Qingguo Li
The ability to increase the bioavailability and dissolution of poorly soluble hydrophobic drugs has been a major challenge for pharmaceutical development. This study shows that the dissolution rate, apparent solubility and oral bioavailability of tadalafil (Td) can be improved by nano-sized amorphous particles prepared by using antisolvent precipitation. Acetone and an acetone-water solution (v:v, 9:1) were selected as solvents, with deionized water as the antisolvent. The antisolvent precipitation process was conducted at a constant drug concentration of 10 mg/mL, at temperatures of 5, 10 and 15 °C and at volume ratios of antisolvent to solvent (AS/S) of 5, 8 and 10...
December 12, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30553057/anti-inflammatory-action-of-ho-1-co-in-human-bronchial-epithelium-in-response-to-cationic-polypeptide-challenge
#5
Rui-Gang Zhang, Kewu Pan, Yuan Hao, Chung-Yin Yip, Wing-Hung Ko
Carbon monoxide (CO) is an anti-inflammatory gaseous molecule produced endogenously by heme oxygenases (HOs) HO-1 and HO-2. However, the mechanisms underlying the anti-inflammatory effects of CO in the human bronchial epithelium are still not fully understood. In this study, the cationic peptide poly-l-arginine (PLA) was utilized to induce bronchial epithelial damage and subsequent pro-inflammatory cytokine release in the human bronchial epithelial cell line 16HBE14o-. Expression of both HO-1 and HO-2 after PLA exposure was examined...
December 12, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30552913/epinecidin-1-a-marine-fish-antimicrobial-peptide-with-therapeutic-potential-against-trichomonas-vaginalis-infection-in-mice
#6
Han-Ning Huang, Chi-Mu Chuang, Jyh-Yih Chen, Pan Chieh-Yu
Trichomoniasis is caused by infection with the protozoan parasite Trichomonas vaginalis, and prolonged persistence may lead to serious ill effects in patients. Thus, the development of new therapeutic strategies to combat drug-resistant T. vaginalis would be clinically beneficial. Antimicrobial peptides (AMPs) comprise an emerging class of molecules that may serve as effective alternatives to antibiotics. In this report, we demonstrate that the synthetic fish AMP, Epinecidin-1 (Epi-1), acts against T. vaginalis both in vitro and in vivo...
December 12, 2018: Peptides
https://www.readbyqxmd.com/read/30552826/tobacco-smoking-alcohol-drinking-betel-quid-chewing-and-the-risk-of-head-and-neck-cancer-in-an-east-asian-population
#7
Yuan-Chin Amy Lee, Shuang Li, Yuji Chen, Qian Li, Chien-Jen Chen, Wan-Lun Hsu, Pei-Jen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Hongxia Ma, Lin Cai, Baochang He, Yu Wang, Xiaoyan Zhou, Qinghai Ji, Baosen Zhou, Wei Wu, Jie Ma, Paolo Boffetta, Zuo-Feng Zhang, Min Dai, Mia Hashibe
BACKGROUND: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. METHODS: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression...
December 15, 2018: Head & Neck
https://www.readbyqxmd.com/read/30552714/par2-promotes-m1-macrophage-polarization-and-inflammation-via-foxo1-pathway
#8
Liang Chen, Beiyao Gao, Yadong Zhang, Hanyu Lu, Xiaobo Li, Luanfeng Pan, Lianhua Yin, Xiuling Zhi
Macrophages polarization plays essential but different roles in most diseases such as atherosclerosis, adipose tissue inflammation, and insulin resistance. Our previous study revealed that protease-activated receptor 2 (PAR2), a G-protein coupled receptor influenced macrophage function, but little is known regarding the regulation of macrophage polarization process and its potential mechanisms. In the present study, bone marrow-derived macrophages (BMDM) isolated from C57/BL6 mice and cultured with L929-conditional medium and murine macrophage cell line RAW264...
December 14, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30552276/prognostic-value-of-modified-early-warning-score-generated-in-a-chinese-emergency-department-a-prospective-cohort-study
#9
Xiaohua Xie, Wenlong Huang, Qiongling Liu, Wei Tan, Lu Pan, Lei Wang, Jian Zhang, Yunyun Wang, Yingchun Zeng
OBJECTIVES: This study aimed to validate the performance of the Modified Early Warning Score (MEWS) in a Chinese emergency department and to determine the best cut-off value for in-hospital mortality prediction. DESIGN: A prospective, single-centred observational cohort study. SETTING: This study was conducted at a tertiary hospital in South China. PARTICIPANTS: A total of 383 patients aged 18 years or older who presented to the emergency department from 17 May 2017 through 27 September 2017, triaged as category 1, 2 or 3, were enrolled...
December 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/30552192/the-ferredoxin-like-protein-ferr-regulates-prbp-activity-in-liberibacter-asiaticus
#10
Lei Pan, Danilo da Silva, Fernando A Pagliai, Natalie A Harrison, Claudio F Gonzalez, Graciela L Lorca
In Liberibacter asiaticus , PrbP is an important transcriptional accessory protein that regulates gene expression through interactions with the RNA polymerase β-subunit and a specific sequence on the promoter region. The constitutive expression of prbP observed upon chemical inactivation of PrbP/DNA interactions in vivo indicated that the expression of prbP was not auto-regulated at the level of transcription. This observation suggested that a modulatory mechanism via protein-protein interactions maybe involved...
December 14, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/30551674/integration-of-satellite-data-with-high-resolution-ratio-improvement-of-spectral-quality-with-preserving-spatial-details
#11
Aleksandra Sekrecka, Michal Kedzierski
Commonly used image fusion techniques generally produce good results for images obtained from the same sensor, with a standard ratio of spatial resolution (1:4). However, an atypical high ratio of resolution reduces the effectiveness of fusion methods resulting in a decrease in the spectral or spatial quality of the sharpened image. An important issue is the development of a method that allows for maintaining simultaneous high spatial and spectral quality. The authors propose to strengthen the pan-sharpening methods through prior modification of the panchromatic image...
December 13, 2018: Sensors
https://www.readbyqxmd.com/read/30551434/pterostilbene-a-bioactive-component-of-blueberries-alleviates-renal-fibrosis-in-a-severe-mouse-model-of-hyperuricemic-nephropathy
#12
Jing Pan, Min Shi, Lingzhi Li, Jing Liu, Fan Guo, Yanhuan Feng, Liang Ma, Ping Fu
Accumulating evidences indicated that hyperuricemia was an independent risk factor for kidney diseases and contributed to kidney fibrosis. Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases. In the study, pterostilbene (PTE) as a bioactive component of blueberries was confirmed to possess lowering serum uric acid and renal protective functions by the decrease of serum creatinine, BUN, urine albumin, and urine albumin-to-creatinine ratio (uACR) in a mouse model of hyperuricemic nephropathy (HN)...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551326/retinal-nerve-fiber-layer-thickness-changes-in-schizophrenia-a-meta-analysis-of-case-control-studies
#13
Junru Pan, Yuanyuan Zhou, Yi Xiang, Jiguo Yu
Studies using optical coherence tomography (OCT) to compare retinal nerve fiber layer thickness in subjects with schizophrenia and healthy controls have yielded inconsistent results. We aimed to compare changes in retinal nerve fiber layer thickness in schizophrenia and healthy controls via a meta-analysis. Relevant studies were selected via an electronic search of the Cochrane Controlled Trials Register, Pubmed, and Embase. All included studies measured average and 4-quadrant (temporal, superior, nasal, and inferior) retinal nerve fiber layer thickness via OCT...
December 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30551305/poly-%C3%AE%C2%B5-caprolactone-modified-organic-dyes-nanoparticles-for-noninvasive-long-term-fluorescence-imaging
#14
Li Quan, Tingting Sun, Yanchun Wei, Yuebin Lin, Tao Gong, Changjiang Pan, Hongyan Ding, Wei Liu, Zhigang Xie
Application of organic dyes is limited in biomedical fields due to the rapid self-quenching, poor stability and water solubility. In this work, polymer modified organic dyes is developed through the dyes initiating polymerization. The polymer length is studied by tuning the amount of monomer. With an optimal molecule weight of the polymer, the π-π stacking from π-conjugated organic fluorescent dyes and fluorescence quenching are inhibited, resulting in an enhancement of fluorescence intensity and photostability...
January 1, 2019: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30551118/mir-23a-3p-acts-as-an-oncogene-and-potential-prognostic-biomarker-by-targeting-pnrc2-in-rcc
#15
Jing Quan, Xiang Pan, Yawen Li, Yimin Hu, Lingzhi Tao, Zuwei Li, Liwen Zhao, Jingyao Wang, Hang Li, Yulin Lai, Liang Zhou, Canbin Lin, Yaoting Gui, Jing Ye, Fangting Zhang, Yongqing Lai
BACKGROUND: Renal cell carcinoma (RCC) is a most common kidney malignancy, with atypical symptoms in the early stage and poor outcome in the late stage. Recently, emerging evidence revealed that some miRNAs play an essential role in the tumorigenesis and progression of RCC. Therefore, the aim of this study is that understand the detailed molecular mechanism of miR-23a-3p in RCC and identify its potential clinical value. METHODS: In this study, RT-qPCR, wound scratch assay, cell proliferation assay, transwell assay and flow cytometry assay were performed to detect miR-23a-3p expression and its proliferation, migration and apoptosis in RCC...
December 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30551031/the-protective-effect-of-sophocarpine-in-osteoarthritis-an-in-vitro-and-in-vivo-study
#16
Dengying Wu, Xingyu Zhu, Xiaodiao Kang, Huasong Huang, Jiale Yu, Jun Pan, Xutong Zhang
BACKGROUND: Osteoarthritis (OA) is a type of degenerative joint disease affecting millions of individuals worldwide. However, there are currently no great inflammatory treatments available for it. Sophocarpine (SPC), one of the key bioactive compounds derived from Sophora flavescens, has shown remarkable anti-inflammatory effects. METHODS: In this study, we evaluated the effect of SPC on preventing the progression of OA and investigated its molecular target involved...
December 11, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30550981/selection-and-characterization-of-protective-anti-chikungunya-virus-single-domain-antibodies
#17
Jinny L Liu, Lisa C Shriver-Lake, Dan Zabetakis, George P Anderson, Ellen R Goldman
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes an arthralgia febrile illness that has affected millions of people on three continents. Previously, neutralizing monoclonal antibodies that have prophylactic and therapeutic activity were found to remove virus in joint tissues, thereby reducing the severity of symptoms in mice and non-human primates. In this study, we sought to develop thermostable small recombinant antibodies against CHIKV for future diagnostic, prophylactic and therapeutic applications...
December 11, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30550952/the-t-type-calcium-channel-antagonist-z944-alters-social-behavior-in-genetic-absence-epilepsy-rats-from-strasbourg
#18
Wendie N Marks, Nadine K Zabder, Stuart M Cain, Terrance P Snutch, John G Howland
Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype closely correlated to that of human absence epilepsies. Similar to the human conditions, GAERS display social abnormalities. Previous studies have only demonstrated social abnormalities in female GAERS, whereas social problems are observed in male and female patients...
December 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/30550638/optogenetic-control-of-ips-cell-derived-neurons-in-2d-and-3d-culture-systems-using-channelrhodopsin-2-expressed-by-the-syn1-and-camkii-promoters
#19
Si-Yuen Lee, Julian H George, David A Nagel, Hua Ye, Gray Kueberuwa, Leonard W Seymour
Development of optogenetically controllable human neural network model in three-dimensional (3D) can provide an investigative system that is physiologically relevant or mimic to the human brain. Light-sensitive neurons were generated by transducing channelrhodopsin-2 (ChR2) into human induced pluripotent stem cells (hiPSCs) derived neural progenitor cells (Axol) using lentiviruses and cell-type specific promoters. A mixed population of human iPSC-derived cortical neurons, astrocytes and progenitor cells was obtained (Axol-ChR2) upon neural differentiation...
December 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/30550564/prediction-of-antibiotic-resistance-in-escherichia-coli-from-large-scale-pan-genome-data
#20
Danesh Moradigaravand, Martin Palm, Anne Farewell, Ville Mustonen, Jonas Warringer, Leopold Parts
The emergence of microbial antibiotic resistance is a global health threat. In clinical settings, the key to controlling spread of resistant strains is accurate and rapid detection. As traditional culture-based methods are time consuming, genetic approaches have recently been developed for this task. The detection of antibiotic resistance is typically made by measuring a few known determinants previously identified from genome sequencing, and thus requires the prior knowledge of its biological mechanisms. To overcome this limitation, we employed machine learning models to predict resistance to 11 compounds across four classes of antibiotics from existing and novel whole genome sequences of 1936 E...
December 14, 2018: PLoS Computational Biology
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