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https://www.readbyqxmd.com/read/30121467/the-burden-of-overall-and-cause-specific-respiratory-morbidity-due-to-ambient-air-pollution-in-sichuan-basin-china-a-multi-city-time-series-analysis
#1
Hang Qiu, Haiyan Yu, Liya Wang, Xiaojuan Zhu, Mengdie Chen, Li Zhou, Ren Deng, Yanlong Zhang, Xiaorong Pu, Jingping Pan
Few studies have investigated the respiratory morbidity burden due to ambient air pollution in China, especially in a multi-city setting. This study aimed to estimate the short-term effects of ambient air pollutants (PM10 , PM2.5 , NO2 and SO2 ) on hospital admissions (HAs) for overall and cause-specific respiratory diseases, as well as the associated burden in 17 cities of Sichuan Basin, China during 2015-2016. Firstly, city-specific effect estimates for each pollutant on respiratory HAs were obtained using generalized additive model with quasi-Poisson link, and then random- or fixed-effects meta-analysis was applied to pool the effect estimates at the regional level...
August 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/30121348/predictors-of-pain-severity-trajectory-in-older-adults-a-10-7-year-follow-up-study
#2
Feng Pan, Jing Tian, Dawn Aitken, Flavia Cicuttini, Graeme Jones
OBJECTIVES: To identify distinct pain trajectories over 10.7 years and to examine predictors of identified pain trajectories in an older population and those with radiographic knee osteoarthritis (ROA). METHODS: 963 participants (aged 50-80 years) from a population-based cohort had baseline demographic, psychological, lifestyle and comorbidities data collected. T1-and T2-weighted MRI of the right knee was performed to measure knee structural pathology--cartilage defects, bone marrow lesions (BMLs) and effusion-synovitis...
August 16, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/30120651/eno2-knock-out-mutants-in-arabidopsis-modify-the-regulation-of-the-gene-expression-response-to-nacl-stress
#3
Chao Chen, Yonghua Zhang, Pan Ye, Xiaofeng Ma, Chaoxing Zheng, Genfa Zhang
There is a growing awareness that some dual-function enzymes may provide a directly evidence that metabolism could feed into the regulation of gene expression via metabolic enzymes. However, the mechanism by which metabolic enzymes control gene expression to optimize plant stress responses remains largely unknown in Arabidopsis thaliana. LOS2/ENO2 is a bifunctional gene transcribed a functional RNA that translates a full-length version of the ENO2 protein and a truncated version of the MBP-1 protein. Here, we report that eno2 negatively regulates plant tolerance to salinity stress...
August 17, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30120130/fundus-examination-of-199-851-newborns-by-digital-imaging-in-china-a-multicentre-cross-sectional-study
#4
He Tang, Na Li, Zhan Li, Meiju Zhang, Meirong Wei, Changbing Huang, Jihong Wang, Fuxin Li, Hong Wang, Zijiang Liu, Liying He, Yangyang Cheng, Wei Chen, Liwen Jin, Limin Gong, Jun Lu, Yan Xue, Manxiang Su, Yanhong Wang, Haiming Mo, Zhenwen Chen, Wei Guo, Yun Li, Hong Pan, Wei Zhang, Xu Ma, Xi Jin, Binbin Wang
BACKGROUND: The prevalence of ocular abnormalities of newborn in China has seldom been reported. To report the implementation of digital imaging in ocular screening of all newborns in multiple centres in China and to describe the abnormal findings of fundus examination, we did the cross-sectional study. METHODS: Fundus examinations were performed on newborns within the 42 days after birth using a RetCam wide-field digital imaging system. Digital images of the posterior pole, superior, nasal and temporal retinal fields of each participant were taken...
August 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/30119896/sexual-dimorphism-of-body-size-in-an-african-fossil-ape-nacholapithecus-kerioi
#5
Yasuhiro Kikuchi, Masato Nakatsukasa, Hiroshi Tsujikawa, Yoshihiko Nakano, Yutaka Kunimatsu, Naomichi Ogihara, Daisuke Shimizu, Tomo Takano, Hideo Nakaya, Yoshihiro Sawada, Hidemi Ishida
Sexual size dimorphism in the African fossil ape Proconsul nyanzae (18 million years ago, 18 Ma) has been previously documented. However, additional evidence for sexual dimorphism in Miocene hominoids can provide great insight into the history of extant hominoid mating systems. The present study focused on body mass (BM) sexual dimorphism in Nacholapithecus kerioi from the Middle Miocene (16-15 Ma) in Africa. Bootstrap analysis revealed that P. nyanzae BM sexual dimorphism was lower than that in Pan troglodytes, which exhibits moderate sexual dimorphism, as reported previously...
August 14, 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/30119680/lncrna-kral-reverses-5-fluorouracil-resistance-in-hepatocellular-carcinoma-cells-by-acting-as-a-cerna-against-mir-141
#6
Lili Wu, Chenwei Pan, Xin Wei, Yifen Shi, Jianjian Zheng, Xiangyang Lin, Liang Shi
BACKGROUND: 5-Fluorouracil (5-FU) has been widely applied to treat various types of cancers, including hepatocellular carcinoma (HCC). However, primary or acquired 5-FU resistance prevents the clinical application of this drug in cancer therapy. Herein, our study is the first to demonstrate that lower expression of KRAL, a long non-coding RNA (lncRNA), mediates 5-FU resistance in HCC via the miR-141/Keap1 axis. METHODS: Cell proliferation assays, western blot analysis, qRT-PCR, the dual-luciferase reporter assay and RNA immunoprecipitation were performed to investigate the mechanisms by which KRAL mediates 5-fluorouracil resistance in HCC cell lines...
August 17, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/30119596/the-t-probe-an-integrated-microscale-device-for-online-in-situ-single-cell-analysis-and-metabolic-profiling-using-mass-spectrometry
#7
Renmeng Liu, Ning Pan, Yanlin Zhu, Zhibo Yang
The exploration of single cells reveals cell heterogeneity and biological principle of cellular metabolism. Although a number of mass spectrometry (MS) based single cell MS (SCMS) techniques have been dedicatedly developed with high efficiency and sen-sitivity, limitations still exist. In this work, we introduced a microscale multifunctional device, the T-probe, which integrates cellu-lar contents extraction and immediate ionization, to implement online in situ SCMS analysis at ambient conditions with minimal sample preparation...
August 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30119564/photonics-based-mimo-radar-with-high-resolution-and-fast-detection-capability
#8
Fangzheng Zhang, Bindong Gao, Shilong Pan
A photonics-based multiple-input-multiple-output (MIMO) radar is proposed and demonstrated based on wavelength-division-multiplexed broadband microwave photonic signal generation and processing. The proposed radar has a large operation bandwidth, which helps to achieve an ultra-high range resolution. Compared with a monostatic radar, improved radar performance and extended radar applications originated from the MIMO architecture can be achieved. In addition, low-speed electronics with real-time signal processing capability is feasible...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119522/point-ahead-demonstration-of-a-transmitting-antenna-for-satellite-quantum-communication
#9
Xuan Han, Hai-Lin Yong, Ping Xu, Wei-Yang Wang, Kui-Xing Yang, Hua-Jian Xue, Wen-Qi Cai, Ji-Gang Ren, Cheng-Zhi Peng, Jian-Wei Pan
A low-divergence beam is an essential prerequisite for a high-efficiency long-distance optical link, particularly for satellite-based quantum communication. A point-ahead angle, caused by satellite motion, is always several times larger than the divergence angle of the signal beam. We design a novel transmitting antenna with a point-ahead function, and provide an easy-to-perform calibration method with an accuracy better than 0.2 μrad. Subsequently, our antenna establishes an uplink to the quantum satellite, Micius, with a link loss of 41-52 dB over a distance of 500-1,400 km...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119499/inverse-method-to-engineer-uniform-intensity-focal-fields-with-arbitrary-shape
#10
Guan-Lin Zhang, Xu-Zhen Gao, Yue Pan, Meng-Dan Zhao, Dan Wang, Hai-Han Zhang, Yongnan Li, Chenghou Tu, Hui-Tian Wang
We present an inverse method to engineer uniform-intensity focal fields with arbitrary shape. Amplitude, phase, and polarization states, as adjustable parameters, are used to seek the desired focal fields in the non-iterative computational procedure. Our method can be applied to the cases with low and moderate numerical aperture (NA), in which case the feasibility and validity of our approach have been demonstrated in theory, simulation and experiment, respectively. For the case of higher NA, simulated results based on the Richards-Wolf diffraction integral are shown...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119443/accelerating-computation-of-cgh-using-symmetric-compressed-look-up-table-in-color-holographic-display
#11
Tao Zhao, Juan Liu, Qiankun Gao, Pan He, Yu Han, Youngtian Wang
The huge computational complexity is a challenge for computer-generated hologram (CGH) calculation in a holographic display. In this paper, we propose a symmetric compressed look-up-table algorithm to accelerate CGH computation based on the Fresnel diffraction theory and compressed look-up-table algorithm. In offline computation, the memory usage of horizontal and vertical modulation factors is reduced to the order of Kilobytes by using translational symmetric compression and wavelength separation. In online computation, we develop a one-time generation of color holograms method which is accelerated by matrix convolution operation...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119170/mir-32-promotes-tumorigenesis-of-colorectal-cancer-by-targeting-bmp5
#12
Erfei Chen, Qiqi Li, Hua Wang, Pan Zhang, Xiaojuan Zhao, Fangfang Yang, Jin Yang
MiRNA regulation is a crucial way of epigenetic changes. Mir-32 has been reported in several studies as an oncogene, however, its role and target in colorectal cancer (CRC) remains unclear. In this study, we aimed to explore the role of miR-32 in CRC using bioinformatic analysis and functional assays. We collected 28 pairs of CRC tumor tissues and adjacent normal tissues and confirmed miR-32 was significantly upregulated in CRC. Expression and clinical data from The Cancer Genome Atlas (TCGA) identified miR-32 expression is associated with CRC lymphatic invasion, metastasis, and correlates with patients' poor survival...
July 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30117997/rectangular-structure-based-pose-estimation-method-for-non-cooperative-rendezvous
#13
Limin Zhang, Feng Zhu, Yingming Hao, Wang Pan
Pose estimation for spacecraft is widely recognized as an important technology for space applications. Many space missions require accurate relative pose between the chaser and the target spacecraft. Stereovision is a usual mean to estimate the pose of non-cooperative targets during proximity operations. In this paper, an accurate algorithm for pose estimation is proposed by taking advantage of the geometric structure of the object. With stereo cameras, our approach employs the corners of the solar panel as features and uses bundle adjustment to improve the accuracy...
July 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/30117980/interference-reduction-using-pattern-modulation-and-demodulation-for-light-coding-depth-cameras
#14
Yu Pan, Rong Ke Liu, Qiu Chen Du, Chang Wen Chen
Depth extraction systems with multiple light-coding depth cameras (LCDCs) have been widely used in the field of three-dimensional reconstruction in recent years. However, interference among the depth cameras would significantly deteriorate the quality of depth images and thus limit their efficiency in various applications. In this paper, we first establish the linear illumination model of multiple LCDCs to study the property of interference. Since the interference-free pattern is hard to distinguish from the interfered pattern, we present an interference reduction scheme based on pattern modulation and demodulation to address this problem...
June 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/30117954/fast-and-wide-range-optical-beam-steering-with-ultralow-side-lobes-by-applying-an-optimized-multi-circular-optical-phased-array
#15
Fangzheng Zhang, Daocheng Zhang, Shilong Pan
A multi-circular optical phased array (OPA) is proposed and investigated through simulation to realize fast and wide-range optical beam steering with ultralow side lobes. The proposed multi-circular OPA has a circularly symmetrical distribution, and its radical element spacings are optimized by a modified genetic algorithm to achieve the best side lobe suppression. Specifically, the peak side lobe level (PSLL) of the far-field pattern in 0° beam direction reaches as low as 0.0715 for a 73-element optimized multi-circular OPA, which is much better than a multi-circular OPA with uniform radical element spacing (the PSLL is 0...
June 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/30117424/-development-of-resources-technologies-and-services-at-the-china-zebrafish-resource-center
#16
Feng Xiong, Xun Wei Xie, Lu Yuan Pan, Kuo Yu Li, Li Yue Liu, Yun Zhang, Ling Lu Li, Yong Hua Sun
With the rapid growth of the Chinese zebrafish community, there is an increasing demand for various types of zebrafish-related resources and technologies. The China Zebrafish Resource Center (CZRC, web: http://zfish.cn) was established at the Institute of Hydrobiology (IHB), Chinese Academy of Sciences (CAS) in 2012. Till now, CZRC has built the largest zebrafish aquaculture unit in China, organized a resource bank containing more than 1200 zebrafish lines and more than 10 000 frozen sperm samples, among which over 200 mutant and transgenic lines were generated by CZRC...
August 16, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/30117291/new-lncrna-annotation-reveals-extensive-functional-divergence-of-the-transcriptome-in-maize
#17
Linqian Han, Zhenna Mu, Zi Luo, Qingchun Pan, Lin Li
Long non-coding RNAs (lncRNAs), whose sequences are ∼200 bp or longer and unlikely to encode proteins, may play an important role in eukaryotic gene regulation. Although the latest maize (Zea Mays L.) reference genome provides an essential genomic resource, genome-wide annotations of maize lncRNAs have not been updated (Jiao et al. 2017). Here, we report on a large transcriptomic dataset collected from 749 RNA sequencing experiments across different tissues and stages of the maize reference inbred B73 line and 60 from its wild relative teosinte...
August 16, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/30117103/targeting-axon-integrity-to-prevent-chemotherapy-induced-peripheral-neuropathy
#18
Virendra Bhagawan Chine, Ngan Pan Bennett Au, Gajendra Kumar, Chi Him Eddie Ma
Chemotherapy-induced peripheral neuropathy (CIPN) is an irreversible off-target adverse effect of many chemotherapeutic agents such as paclitaxel, yet its mechanism is poorly understood and no preventative measure is available. CIPN is characterized by peripheral nerve damages resulting in permanent sensory function deficits. Our recent unbiased genome-wide analysis revealed that heat shock protein (Hsp) 27 is part of a transcriptional network induced by axonal injury and highly enriched for genes involved in adaptive neuronal responses, particularly axonal regeneration...
August 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30117085/excessive-daytime-sleepiness-in-general-hospital-nurses-prevalence-correlates-and-its-association-with-adverse-events
#19
Liping Chen, Chunliu Luo, Shuai Liu, Weiju Chen, Yaping Liu, Yunjia Li, Yun Du, Haihua Zou, Jiyang Pan
OBJECTIVE: To investigate the prevalence and correlates of excessive daytime sleepiness (EDS) in a population of hospital nurses in South China as well as the influence of EDS on the occurrence of adverse events. METHODS: A total of 1102 nurses working in a large medical center were invited to participate in this cross-sectional study (96.9% females, mean age 29.6 years). They all completed a self-reported questionnaire consisting of items on demographic variables, lifestyle factors, insomnia, anxiety, depression, and both work-related and sleep-related characteristics...
August 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/30117035/a-22-bp-deletion-in-ospls3-gene-encoding-a-duf266-containing-protein-is-implicated-in-rice-leaf-senescence
#20
Kunyu Li, Yaodong Chen, Yanmin Luo, Fudeng Huang, Chaoyue Zhao, Fangmin Cheng, Xun Xiang, Gang Pan
Key message The OsPLS3 locus was isolated by map-based cloning that encodes a DUF266-containing protein. OsPLS3 regulates the onset of leaf senescence in rice. Glycosyltransferases (GTs) are one of the most important enzyme groups required for the modification of plant secondary metabolites and play a crucial role in plant growth and development, however the biological functions of most GTs remain elusive. We reported here the identification and characterization of a novel Oryza sativa premature leaf senescence mutant (ospls3)...
August 16, 2018: Plant Molecular Biology
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