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https://www.readbyqxmd.com/read/29894673/-prevention-of-periprocedural-kidney-ingury-by-loading-doses-of-statins-in-elective-percutaneous-%C3%B1-oronary-interventions
#1
E O Vershinina, A N Repin, M S Timofeev, V V Udut
PURPOSE OF THE STUDY: To compare the effect of loading doses of atorvastatin and rosuvastatin on the value of the acute kidney injury and acute inflammatory response to elective percutaneous coronary interventions. MATERIALS AND METHODS: An open prospective comparative study included 68 patients referred for elective percutaneous coronary intervention (PCI). At baseline, all patients had been taking statins for a long time as a standard lipid-lowering therapy. The first group included 33 patients who received a loading dose of 80 mg of atorvastatin (As) 12 hours before the intervention with saving this dose for 2-6 days...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29870326/-long-term-statin-adherence-in-patients-with-stable-angina-after-coronary-stenting
#2
D I Tomilova, Y A Karpov, V V Lopukhova
PURPOSE: To study adherence to therapy with statins and its relation to development of cardio-vascular complications (CVC) in patients with stable angina after elective percutaneous coronary intervention (PCI) at five-year observation. MATERIALS AND METHODS: This study comprised 574 patients with stable angina (81 % men, mean age 60.3 years) hospitalized for elective PCI. All patients were prescribed therapy in accordance with recommendations on management of stable angina including statins...
May 2018: Kardiologiia
https://www.readbyqxmd.com/read/29733433/statin-therapy-on-glycemic-control-in-type-2-diabetic-patients-a-network-meta-analysis
#3
J Y Cui, R R Zhou, S Han, T S Wang, L Q Wang, X H Xie
WHAT IS KNOWN AND OBJECTIVE: Statins are the cornerstone of primary and secondary prevention of cardiovascular diseases (CVDs) and are effective for the prevention of vascular events in diabetic patients. Diabetes mellitus is an important risk factor for CVDs .The majority of patients with diabetes mellitus benefits from statin therapy. According to the recent clinical guidelines of the American College of Cardiology and the American Heart Association, moderate-intensity or high-intensity statin therapy should be used as the primary prevention for individuals with diabetes mellitus, aged between 40 and 75 years and with low-density lipoprotein cholesterol (LDL-C) from 70 to 189 mg/dL...
August 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29643253/in-vitro-in-vivo-extrapolation-of-oatp1b-mediated-drug-drug-interactions-in-cynomolgus-monkey
#4
Ayşe Ufuk, Rachel E Kosa, Hongying Gao, Yi-An Bi, Sweta Modi, Dana Gates, A David Rodrigues, Larry M Tremaine, Manthena V S Varma, J Brian Houston, Aleksandra Galetin
Hepatic organic anion-transporting polypeptides (OATP) 1B1 and 1B3 are clinically relevant transporters associated with significant drug-drug interactions (DDIs) and safety concerns. Given that OATP1Bs in cynomolgus monkey share >90% degree of gene and amino acid sequence homology with human orthologs, we evaluated the in vitro-in vivo translation of OATP1B-mediated DDI risk using this preclinical model. In vitro studies using plated cynomolgus monkey hepatocytes showed active uptake Km values of 2.0 and 3...
June 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29627897/drug-drug-interaction-of-cefiderocol-a-siderophore-cephalosporin-via-human-drug-transporters
#5
Takayuki Katsube, Shiro Miyazaki, Yukitoshi Narukawa, Martha Hernandez-Illas, Toshihiro Wajima
PURPOSE: Cefiderocol, a siderophore cephalosporin, will be used concomitantly with other medications for treatment of bacterial infections. In vitro studies demonstrated inhibition potential of cefiderocol on organic anion transporter (OAT) 1, OAT3, organic cation transporter (OCT) 1, OCT2, multidrug and toxin extrusion (MATE) 2-K, and organic anion transporting polypeptide (OATP) 1B3. The aim of this study was to assess in vivo drug-drug interaction (DDI) potential of cefiderocol using probe substrates for these transporters...
July 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29475008/comparison-of-the-effects-of-rosuvastatin-monotherapy-and-atorvastatin-ezetimibe-combined-therapy-on-the-structure-of-erythrocyte-membranes-in-patients-with-coronary-artery-disease
#6
Małgorzata Olszewska-Banaszczyk, Paulina Jackowska, Paulina Gorzelak-Pabiś, Edyta Pytel, Maria Koter-Michalak, Marlena Broncel
BACKGROUND: Abnormalities in the physical properties of the red blood cells (RBCs) membranes may underlie the defects that are strongly linked to cardiovascular diseases (CVD). The aim of the study was to compare the effects of two therapies of equal hipolipemic efficacy on the erythrocyte membrane fluidity, concentration of membrane cholesterol, lipids peroxidation and RBCs distribution witdh in patients with CVD. METHODS: The study included 44 patients with angiographic evidence of CVD, who despite previous 6-month hypolipemic therapy, did not achieve the concentration of LDL-C <70mg/dl...
April 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29472495/apixaban-and-rosuvas-tatin-pharmacokinetics-in-nonalcoholic-fatty-liver-disease
#7
Rommel G Tirona, Zahra Kassam, Ruth Strapp, Mala Ramu, Catherine Zhu, Melissa Liu, Ute I Schwarz, Richard B Kim, Bandar Al-Judaibi, Melanie D Beaton
There is little known about the impact of nonalcoholic fatty liver disease (NAFLD) on drug metabolism and transport. We examined the pharmacokinetics of oral apixaban (2.5 mg) and rosuvastatin (5 mg) when administered simultaneously in subjects with magnetic resonance imaging-confirmed NAFLD ( N = 22) and healthy control subjects ( N = 12). The area under the concentration-time curve to the last sampling time (AUC0-12 ) values for apixaban were not different between control and NAFLD subjects (671 and 545 ng/ml × hour, respectively; P = 0...
May 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29402848/do-statins-affect-thyroid-volume-and-nodule-size-in-patients-with-hyperlipidemia-in-a-region-with-mild-to-moderate-iodine-deficiency-a-prospective-study
#8
Canan Demir, Cuneyd Anil, Yusuf Bozkus, Umut Mousa, Altug Kut, Asli Nar, Neslihan B Tutuncu
OBJECTIVE: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity. SUBJECTS AND METHODS: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). The 37 patients in the control group, assessed as not requiring drugs, made only lifestyle changes...
2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29059648/determine-the-effectiveness-of-lipid-lowering-therapy-in-patients-with-chronic-obstructive-pulmonary-disease-combined-with-coronary-heart-disease
#9
Vyacheslav Zhdan, Galina Khaymenova, Lyudmila Shilkina, Daria Martynyuk, Marina Babanina, Tatyana Mamontova
INTRODUCTION: In complex treatment of chronic obstructive pulmonary disease (COPD) combined with ischemic heart disease (IHD) more and more attention is drawn to pleiotropic effect of statins. The aim of our researches became determining the effectivity of utilization of rosuvastatin (CRESTOR®, IPR PHARMACEUTICALS, Inc.) in complex treatment of COPD combined with IHD. MATERIALS AND METHODS: Basing on pulmonology department of Poltava regional clinical hospital, 30 patients with COPD combined with IHD have been examined (stable effort angina FC II) aged from 51 to 67 y...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28630863/the-effects-of-melatonin-on-elevated-liver-enzymes-during-statin-treatment
#10
Cezary Chojnacki, Aleksandra Błońska, Jan Chojnacki
Taking statins can cause increase in the level of aspartate and alanine aminotransferase. The aim of this study was to assess the usefulness of melatonin in counteracting the adverse hepatic events from statins. Methods . The research program included 60 patients (aged 47-65 years, 41 women and 19 men) with hyperlipidemia taking atorvastatin or rosuvastatin at a dose of 20-40 mg daily. The patients were randomly allocated in two groups. Group I ( n = 30) was recommended to take the same statin at a standardized daily dose of 20 mg together with melatonin at a dose of 2 × 5 mg...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28533679/effect-of-epigallocatechin-3-gallate-major-ingredient-of-green-tea-on-the-pharmacokinetics-of-rosuvastatin-in-healthy-volunteers
#11
Tae-Eun Kim, Na Ha, Yunjeong Kim, Hyunsook Kim, Jae Wook Lee, Ji-Young Jeon, Min-Gul Kim
Previous in vitro studies have demonstrated the inhibitory effect of green tea on drug transporters. Because rosuvastatin, a lipid-lowering drug widely used for the prevention of cardiovascular events, is a substrate for many drug transporters, there is a possibility that there is interaction between green tea and rosuvastatin. The aim of this study was to investigate the effect of green tea on the pharmacokinetics of rosuvastatin in healthy volunteers. An open-label, three-treatment, fixed-sequence study was conducted...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28294846/-comparative-randomized-study-of-the-effects-of-long-term-therapy-with-rosuvastatin-and-with-combination-of-atorvastatin-and-ezetimibe-on-carbohydrate-metabolism-and-adipokynes-levels-in-patients-with-coronary-artery-disease-and-diabetes-mellitus
#12
O A Koshelskaya, I V Vinnitskaya, T Yu Konko, E S Kravchenko, T E Suslova, R S Karpov
OBJECTIVE: This open randomized study compares the effects of 24-week-long treatment with rosuvastatin and with atorvastatin coadministered with ezetimibe on the parameters of carbohydrate metabolism and the plasma levels of adipokynes in patients with coronary artery disease and type 2 diabetes mellitus or impaired glucose tolerance (IGT). METHOD: A total of 31 patients with coronary artery disease and type 2 diabetes mellitus or IGT were recruited in the study...
March 2015: Kardiologiia
https://www.readbyqxmd.com/read/27830382/ticagrelor-and-rosuvastatin-have-additive-cardioprotective-effects-via-adenosine
#13
Yochai Birnbaum, Gilad D Birnbaum, Itamar Birnbaum, Sven Nylander, Yumei Ye
BACKGROUND: Ticagrelor inhibits the equilibrative-nucleoside-transporter-1 and thereby, adenosine cell re-uptake. Ticagrelor limits infarct size (IS) in non-diabetic rats and the effect is adenosine-dependent. Statins, via ecto-5'-nucleotidase activation, also increase adenosine levels and limit IS. HYPOTHESIS: Ticagrelor and rosuvastatin have additive effects on myocardial adenosine levels, and therefore, on IS and post-reperfusion activation of the NLRP3-inflammasome...
December 2016: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/27478473/rosuvastatin-intensifies-the-beneficial-effects-of-rho-kinase-inhibitor-in-reversal-of-monocrotaline-induced-pulmonary-hypertension
#14
Magdalena Jasińska-Stroschein, Jacek Owczarek, Urszula Sołtysiak, Daria Orszulak-Michalak
INTRODUCTION: It remains controversial whether statins have a beneficial effect on pulmonary arterial hypertension (PAH). This study is intended to evaluate whether statin, co-administered with Rho-kinase inhibitor, could enhance its efficacy. Although Rho-kinase inhibitors, including fasudil, have been reported to improve pulmonary hypertension in experimental and clinical studies, the combination of these agents has not been tested in the treatment of pulmonary hypertension (PH). MATERIAL AND METHODS: The effects of such a regimen on hemodynamics, right ventricle hypertrophy, and Rho-associated protein kinase (ROCK) activity in experimental monocrotaline (MCT)-induced pulmonary hypertension were examined...
August 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27347563/association-of-lipoproteins-insulin-resistance-and-rosuvastatin-with-incident-type-2-diabetes-mellitus-secondary-analysis-of-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Sagar B Dugani, Akintunde O Akinkuolie, Nina Paynter, Robert J Glynn, Paul M Ridker, Samia Mora
IMPORTANCE: Statins decrease levels of low-density lipoprotein (LDL) and triglycerides as well as cardiovascular events but increase the risk for a diagnosis of type 2 diabetes mellitus (T2DM). The risk factors associated with incident T2DM are incompletely characterized. OBJECTIVE: To investigate the association of lipoprotein subclasses and size and a novel lipoprotein insulin resistance (LPIR) score (a composite of 6 lipoprotein measures) with incident T2DM among individuals randomized to a high-intensity statin or placebo...
May 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27242350/effects-of-rosuvastatin-versus-atorvastatin-alone-or-in-combination-on-lipoprotein-a
#16
COMPARATIVE STUDY
Marija Vavlukis, Kristina Mladenovska, Arlinda Daka, Aleksandar Dimovski, Saska Domazetovska, Sonja Kuzmanovska, Sasko Kedev
BACKGROUND: There are little evidences about the therapeutic efficacy of different lipid-lowering agents in the reduction of elevated lipoprotein(a) [Lp(a)]. OBJECTIVE: testing the effect of different lipid-lowering agents on elevated Lp(a). METHODS: prospective interventional study performed in patients with CAD, or high CAD risk, with Lp(a), >50 mg/dL. Lp(a), total cholesterol (C), HDL-C, LDL-C, triglycerides (TGs), apolipoprotein (Apo) A1, Apo B, enzymes of myocyte and hepatic injury were comparatively analyzed between 4 lipid-lowering strategies: rosuvastatin (R group) 40 mg, atorvastatin (A group) 80 mg, atorvastatin 40 mg add-on micronized fenofibrate (A+F group), and atorvastatin 40 mg add-on 1 g extended-release niacin (A+ERN group)...
August 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27232279/failure-of-statins-in-ards-the-quest-for-the-holy-grail-continues
#17
David Grimaldi, Arthur Durand, James Gleeson, Fabio S Taccone
Experimental and clinical observational studies have shown potential benefits of statin administration in the acute respiratory distress syndrome (ARDS) by modulating inflammation and preventing worsening respiratory function. More recently, two randomized clinical trials failed to demonstrate an improved survival of ARDS patients treated with statins. In the first study, conducted by the ARDS Network, 745 patients with sepsis‑associated ARDS were randomized within 48-hours of onset to receive either rosuvastatin or placebo...
November 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27231796/patterns-of-statin-use-in-a-real-world-population-of-patients-at-high-cardiovascular-risk
#18
Iris Lin, Jennifer Sung, Robert J Sanchez, Usha G Mallya, Mark Friedman, Mary Panaccio, Andrew Koren, Peter Neumann, Joseph Menzin
BACKGROUND: Widespread use of statins has improved hypercholesterolemia management, yet a significant proportion of patients remain at risk for cardiovascular (CV) events. Analyses of treatment patterns reveal inadequate intensity and duration of statin therapy among patients with hypercholesterolemia, and little is known about real-world statin use, specifically in subgroups of patients at high risk for CV events. OBJECTIVE: To examine patterns of statin use and outcomes among patients with high-risk features who newly initiated statin monotherapy...
June 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27203715/rosuvastatin-slows-progression-of-subclinical-atherosclerosis-in-patients-with-treated-hiv-infection
#19
RANDOMIZED CONTROLLED TRIAL
Chris T Longenecker, Abdus Sattar, Robert Gilkeson, Grace A McComsey
OBJECTIVE: To determine the effect of statins on the progression of subclinical atherosclerosis in a population of HIV-infected adults on antiretroviral therapy. DESIGN: Double-blind, randomized clinical trial. METHODS: Stopping Atherosclerosis and Treating Unhealthy Bone with RosuvastatiN in HIV infection was a 96-week double-blind, randomized clinical trial of 10 mg daily rosuvastatin (n = 72) vs. placebo (n = 75) in a population of HIV-infected subjects on stable antiretroviral therapy with LDL-cholesterol 130 mg/dl or less (≤3...
September 10, 2016: AIDS
https://www.readbyqxmd.com/read/27098507/statins-increase-mitochondrial-and-peroxisomal-fatty-acid-oxidation-in-the-liver-and-prevent-non-alcoholic-steatohepatitis-in-mice
#20
Han Sol Park, Jung Eun Jang, Myoung Seok Ko, Sung Hoon Woo, Bum Joong Kim, Hyun Sik Kim, Hye Sun Park, In Sun Park, Eun Hee Koh, Ki Up Lee
BACKGROUND: Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes are intracellular organelles that contribute to several crucial metabolic processes, such as facilitation of mitochondrial fatty acid oxidation (FAO) and removal of reactive oxygen species through catalase or plasmalogen synthesis. Statins are known to prevent hepatic steatosis and non-alcoholic steatohepatitis (NASH), but underlying mechanisms of this prevention are largely unknown...
October 2016: Diabetes & Metabolism Journal
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