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Dyslipidemia diabetic

Gurpreet S Wander, Mohammed Yunus Khan Hukkeri, Sachin Yalagudri, Bharti Mahajan, Archana Toppo Panda
Cardiovascular (CV) diseases are a major cause of premature death and disability. Non-communicable diseases (NCD) are responsible for 52% of mortality amongst Indians, of these CV diseases are responsible for 66% of NCD mortality in India. We not only need widespread primary preventive strategy but also need effective secondary prevention protocols to reduce this. Secondary prevention in patients who already had myocardial infarction (MI) or revascularization is of utmost importance to reduce mortality, cardiac events and improve quality of life...
March 2018: Journal of the Association of Physicians of India
Deepak Bhosle, Vandana Bhosle, Jyoti Bobde, Huzaif Shaikh, Rajesh Kadam
Objectives: Patients with prediabetes are not only at increased risk of progression to type 2 diabetes, but they are also at high risk of developing cardiovascular risk compared to normoglycemic people. Further, prediabetes is also often associated with abnormal lipid levels (dyslipidemia). We therefore aimed to evaluate the effect of Saroglitazar in patients with prediabetes and dyslipidemia. Methods: This was a prospective, single centre, single arm study involving patients with pre-diabetes and dyslipidemia...
March 2018: Journal of the Association of Physicians of India
Siddharth N Shah
No abstract text is available yet for this article.
March 2018: Journal of the Association of Physicians of India
Ashutosh Chaturvedi, Arun Kumar
Background: Syncope is a common clinical presentation in emergency department. The diagnostic workup for syncope causes significant man-hour loss and expensive investigations. Most often the battery of investigations does not lead to any conclusive diagnosis. Materials and Methods: This was a descriptive study in which included 50 consecutive patients with the diagnosis of syncope. These patients were admitted to a tertiary care hospital between Sep 2009 to Aug 2011...
January 2018: Journal of the Association of Physicians of India
Shengbang Zheng, Baodong Yao
Risk factors for first-ever stroke have been studied extensively, while those for recurrent stroke are not accurately understood. To provide the adequate secondary prevention for the patients, it is necessary to reveal the risk factors that dominate recurrent stroke. Multiple databases were adopted to search for the relevant studies and full-text articles involving in the risk factors for stroke recurrence were reviewed. Meta-analyses were performed with Review Manager 5.0 to estimate the impact of risk factors included, and forest plots, quality analysis and bias analysis for the articles included were also conducted...
October 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Lu Wang, Jian Hou, Chen Hu, Yun Zhou, Huizhen Sun, Jiafei Zhang, Tian Li, Erwei Gao, Guiyang Wang, Weihong Chen, Jing Yuan
Exposure to polycyclic aromatic hydrocarbons (PAHs) is linked with increased risk of diabetes, whereas socioeconomic status (SES) may contribute to the development of diabetes. However, the mechanisms underlying the relationships between them are unclear. We used structural equation modeling (SEM) to identify mediating factors in the associations of PAHs exposure, low SES with diabetes risk. Data were collected from 2751 Wuhan participants at baseline from the Wuhan-Zhuhai Cohort Study (n = 3053). They answered the questionnaires regarding socio-demographic, participated physical examinations and provided urine samples for measurements of urinary monohydroxy-polycyclic aromatic hydrocarbons (OH-PAHs) levels...
January 15, 2019: Science of the Total Environment
Umberto Marcello Bracale, Anna Maria Giribono, Domenico Spinelli, Luca Del Guercio, Narayana Pipitò, Doriana Ferrara, David Barillà, Danilo Barbarisi, Graziana Derone, Filippo Benedetto
BACKGROUND: The aim of this study is to retrospectively analyze the early and long-term outcomes of endovascular treatment of TransAtlantic Inter-Society Consensus II class C and D (TASC II) aorto-iliac occlusive disease with an expanded-polytetrafluoroethylene-covered stent graft. METHODS: Between January 2006 and November 2017 sixty-one patients (53 males, 8 females), with symptomatic aorto-iliac stenotic and/or occlusive disease, were treated with Viabahn (W...
October 16, 2018: Annals of Vascular Surgery
Henriette Holst Nerild, Mikkel Bring Christensen, Filip Krag Knop, Andreas Brønden
Type 2 diabetes (T2D) is a major global health challenge associated with increased cardiovascular morbidity and mortality. Intervention strategies managing multiple risk factors (hyperglycemia, hypertension and dyslipidemia) in patients with T2D can reduce the risk of cardiovascular disease by ~50%. Areas covered: Herein, the authors provide an update on the development and clinical potential of colesevelam as a glucose-lowering drug in T2D. Furthermore, they outline the pharmacokinetics, pharmacodynamics and the clinical efficacy and safety data from the studies carried out to obtain market authorization for colesevelam...
October 19, 2018: Expert Opinion on Drug Discovery
Katharina Warncke, Sebastian Kummer, Peter Herbert Kann, Dominik Bergis, Esther Bollow, Michael Hummel, Flavius Zoicas, Sebastian Wernert, Reinhard W Holl
BACKGROUND: Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry. METHODS: Patients from the registry≥18 years of age with diabetes and acromegaly or Cushing´s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9...
October 17, 2018: Experimental and Clinical Endocrinology & Diabetes
Bogusław Okopień, Łukasz Bułdak, Aleksandra Bołdys
The need to reduce residual cardiovascular risk led to the development of novel therapeutic strategies to improve patients' outcomes. The residual risk in people with atherogenic dyslipidemia, despite LDL reduction obtained mainly by statins, remains high. Fibrates in those patients lead to significant clinical improvements. Those include reduction in the progression of atherosclerosis, which translates into decrease in cardiovascular events and improvements in microvascular diabetic complications. Furthermore there are other clinical and biochemical benefits connected with fibrate therapy (e...
October 17, 2018: Expert Review of Clinical Pharmacology
Petter Bjornstad, Robert H Eckel
PURPOSE OF REVIEW: Insulin resistance (IR) is recognized to play an important role in the pathogenesis of dyslipidemia. This review summarizes the complex interplay between IR and dyslipidemia in people with and without diabetes. RECENT FINDINGS: IR impacts the metabolism of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C) by several mechanisms. Trials with insulin sensitizing therapies, including biguanides and thiazolidinediones, have provided inconsistent results on lipid lowering in people with and without diabetes...
October 17, 2018: Current Diabetes Reports
Anna Hernández-Aguilera, Salvador Fernández-Arroyo, Noemí Cabre, Fedra Luciano-Mateo, Gerard Baiges-Gaya, Montserrat Fibla, Vicente Martín-Paredero, Javier A Menendez, Jordi Camps, Jorge Joven
Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated with other highly prevalent and related conditions, such as diabetes, dyslipidemia, and hypertension. We have measured energy-balance-associated metabolite concentrations in the plasma of PAD patients segregated by the severity of the disease and in plasma of healthy volunteers using a quantitative and targeted metabolomic approach...
2018: Mediators of Inflammation
Emre Bora, Roger S McIntyre, Aysegul Ozerdem
BACKGROUND: Individuals with bipolar disorder (BD) have a higher prevalence of obesity and metabolic syndrome (MetS) compared with the general population. Obesity and MetS are associated with cognitive deficits and brain imaging abnormalities in the general population. Obesity and components of MetS might potentially associate with neuroimaging and neurocognitive findings in BD. METHODS: A literature search of studies investigating the association between obesity (and other components of MetS) and neurocognitive and neuroimaging findings in BD was conducted...
October 17, 2018: Psychological Medicine
Yaru Li, Liyun Zhao, Dongmei Yu, Gangqiang Ding
OBJECTIVES: This study aimed to examine the prevalence and risk factors of dyslipidemia in different diabetic progression stages among middle-aged and elderly Chinese populations. METHODS: The 2010-2012 China National Nutrition and Health Survey (CNNHS) is a nationally representative cross-sectional study. In the present study, a total of 69,974 participants aged ≥ 45 years were included. Dyslipidemia was defined based on the Chinese adult dyslipidemia prevention guide...
2018: PloS One
Ahmad Hassan, Ronen Jaffe, Ronen Rubinshtein, Basheer Karkabi, David A Halon, Moshe Y Flugelman, Barak Zafrir
BACKGROUND: Contemporary data on clinical profiles and long-term outcomes of young adults with coronary artery disease (CAD) are limited. OBJECTIVES: To determine the risk profile, presentation, and outcomes of young adults undergoing coronary angiography. METHODS: A retrospective analysis (2000-2017) of patients aged ≤ 35 years undergoing angiography for evaluation and/or treatment of CAD was conducted. RESULTS: Coronary angiography was performed in 108 patients (88% males): 67 acute coronary syndrome (ACS) and 41 non-ACS chest pain syndromes...
October 2018: Israel Medical Association Journal: IMAJ
So Young Kim, Jae-Sung Lim, Il Gyu Kong, Hyo Geun Choi
This study aimed to explore the risk of dementia in a middle- and older-aged population with severe or profound hearing impairments. Data were collected for the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Participants aged 40 or older were selected. The 4,432 severely hearing-impaired participants were matched 1:4 with 17,728 controls, and the 958 profoundly hearing-impaired participants were matched 1:4 with 3,832 controls who had not reported any hearing impairment. Age, sex, income, region of residence, hypertension, diabetes mellitus, and dyslipidemia histories were matched between hearing-impaired and control groups...
October 15, 2018: Scientific Reports
Vincenzo Marzolla, Andrea Armani, Caterina Mammi, Alessandra Feraco, Massimiliano Caprio
Atherosclerosis is due to a chronic inflammatory response affecting vascular endothelium and is promoted by several factors such as hypertension, dyslipidemia, and diabetes. To date, there is evidence to support a role for circulating aldosterone as a risk factor for the development of cardiovascular disease. Transgenic mouse models have been generated to study cellular and molecular processes leading to atherosclerosis. In this manuscript, we describe a protocol that takes advantage of continuous infusion of aldosterone in ApoE-/- mice and generates atherosclerotic plaques in the aortic root after 4 weeks of treatment...
September 26, 2018: Journal of Visualized Experiments: JoVE
Young Bok Lee, Ji Hyun Lee, Soo Young Lee, Jin-Wou Kim, Dong Soo Yu, Kyung Do Han, Yong Gyu Park
The epidemiology of pemphigus varies among racial populations worldwide. Trends in the incidence of pemphigus have not been investigated based on the Korean National Health Insurance database. This study investigated the incidence and death rate of pemphigus with age using nationwide population data in South Korea. A nationwide population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015. The incidence of pemphigus vulgaris (PV) per 1 000 000 person-years was 2...
October 15, 2018: Journal of Dermatology
Shiqin Peng, Ping Wei, Qun Lu, Rui Liu, Yue Ding, Jiuliang Zhang
The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice...
2018: Journal of Immunology Research
Jung-In Kim, Jeong-A Yun, Yoo-Kyung Jeong, Hee-Jin Baek
The hypoglycemic and hypolipidemic effects of samnamul were investigated. The α-glucosidase inhibitory activity of samnamul in vivo was determined in normal mice. Oral administration of samnamul extract (500 mg/kg) or acarbose (50 mg/kg) significantly reduced the postprandial glucose response. The effects of chronic consumption of samnamul on fasting hyperglycemia and dyslipidemia were determined in C57BL/6 J mice with diabetes mellitus induced by a high-fat/high-sucrose (HFHS) diet. Consumption of samnamul extract at 0...
October 2018: Food Science and Biotechnology
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