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https://www.readbyqxmd.com/read/30539649/the-impact-of-obesity-as-an-independent-risk-factor-for-the-development-of-renal-injury-implications-from-rat-models-of-obesity
#1
Kasi C McPherson, Corbin A Shields, Bibek Poudel, Brianca Fizer, Alyssa Pennington, Ashley Szabo-Johnson, Willie L Thompson, Denise C Cornelius, Jan Michael Williams
Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is a emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these disorders (defined as the metabolic syndrome, MetS) also contribute to the development and progression of renal disease...
December 12, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30539026/implications-of-the-intestinal-microbiota-in-diagnosing-the-progression-of-diabetes-and-the-presence-of-cardiovascular-complications
#2
REVIEW
Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase
The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/30538517/early-detection-of-metabolic-dysregulation-using-water-t-2-analysis-of-biobanked-samples
#3
Ina Mishra, Clinton Jones, Vipulkumar Patel, Sneha Deodhar, David P Cistola
Background: The ability to use frozen biobanked samples from cohort studies and clinical trials is critically important for biomarker discovery and validation. Here we investigated whether plasma and serum water transverse relaxation times (T2 ) from frozen biobanked samples could be used as biomarkers for metabolic syndrome (MetS) and its underlying conditions, specifically insulin resistance, dyslipidemia, and subclinical inflammation. Methods: Plasma and serum aliquots from 44 asymptomatic, non-diabetic human subjects were biobanked at -80°C for 7-9 months...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/30535651/efficacy-and-safety-of-lipase-inhibitor-orlistat-in-japanese-with-excessive-visceral-fat-accumulation-24-week-double-blind-randomized-placebo-controlled-study
#4
Kohji Shirai, Toru Fujita, Michitaka Tanaka, Yuka Fujii, Masatsugu Shimomasuda, Soichi Sakai, Yoshishige Samukawa
INTRODUCTION: Orlistat is an inhibitor of pancreatic lipase and is used as an anti-obesity drug in many countries. However, there are no data available regarding the effects of orlistat on visceral fat accumulation in Japanese subjects. Therefore, this comparative, placebo-controlled, double-blind, randomized study aimed to evaluate the efficacy and safety of orlistat in Japanese participants with excessive visceral fat accumulation and without dyslipidemia, diabetes mellitus, and hypertension ("metabolic diseases")...
December 10, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30535619/aging-and-hyperglycemia-intensify-dyslipidemia-induced-oxidative-stress-and-inflammation-in-rats-assessment-of-restorative-potentials-of-ala-and-epa-dha
#5
Pooja Acharya, Ramaprasad Ravichandra Talahalli
Effect of aging and hyperglycemia on oxidative stress (OS) and inflammation in dyslipidemic conditions has not been elucidated. Hence, in this study, we assessed the implications of aging, hyperglycemia, and also the dietary effect of n-3 fatty acids (α-linolenic acid (ALA) and eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA)) on OS and inflammation in dyslipidemic rats. Dyslipidemia was induced in young and aged rats by feeding high-fat lard (HFL) diet. Diabetes was induced in young dyslipidemic rats by administering streptozotocin 30 days after the induction of dyslipidemia...
December 10, 2018: Inflammation
https://www.readbyqxmd.com/read/30532795/effect-of-bitter-melon-extracts-on-lipid-levels-in-japanese-subjects-a-randomized-controlled-study
#6
Hiroki Kinoshita, Yasuyuki Ogata
Dyslipidemia is exemplified by high levels of low-density lipoprotein cholesterol (LDL-C) and represents a risk factor for cardiovascular diseases and requires therapeutic intervention. Several experimental studies suggest that bitter melon ( Momordica charantia ) improves lipid metabolism in animal models of dyslipidemia and diabetes. This study evaluated the effects of bitter melon extracts on lipid metabolism following a 30-day treatment period in Japanese adults. This randomized, double-blind, placebo-controlled trial included 43 adult volunteers who received either 100 mg of hot-water extracts of bitter melon ( n = 23) or a placebo ( n = 20) three times daily for 30 days...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30532550/which-drugs-cause-treatment-related-problems-analysis-of-10-672-problems-within-the-outpatient-setting
#7
Ghaith M Al-Taani, Sayer I Al-Azzam, Karem H Alzoubi, Mamoon A Aldeyab
Background: Treatment-related problems (TRPs) may pose risks for patients if unaddressed. With the increased complexity of health care, it is important to target pharmacists' efforts to patients that are at high risk for TRPs. Objectives: The present study aimed to identify medications most commonly associated with TRPs. Setting: Outpatient departments of five public and teaching hospitals in Jordan. Method: TRPs and drugs most commonly implicated with TRPs were assessed for patients recruited from outpatient clinics in five major hospitals in Jordan using a standardized and validated pharmaceutical care manual...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30532105/-efectos-sobre-el-perfil-metab%C3%A3-lico-el-%C3%A3-ndice-de-masa-corporal-la-composici%C3%A3-n-corporal-y-la-comorbilidad-en-adolescentes-con-obesidad-m%C3%A3-rbida-que-han-fallado-al-manejo-conservador-para-bajar-de-peso-operados-de-manga-g%C3%A3-strica-laparosc%C3%A3-pica-reporte-del
#8
Jaime Nieto-Zermeño, Ricardo Ordorica Flores, Blanca Del Río-Navarro, Betzabé Salgado-Arroyo, Jorge Mario Molina-Díaz
Introduction: Obesity is a world pandemic; in Mexico 3 out of 10 adolescents suffer from it. Conservative management of morbid obesity is not effective and bariatric surgery is the only useful therapy. International pediatric bariatric surgery series are scarce and in Mexico there is limited experience. Method: We analyze the metabolic repercussions, comorbidities and complications in our series of Mexican adolescents with morbid obesity who underwent a gastric sleeve between 2011 and 2015...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/30531178/association-between-breast-arterial-calcifications-found-on-mammography-and-coronary-artery-calcifications-in-asymptomatic-saudi-women
#9
Ahmed L Fathala, Faisal Mohammed Alabdulkarim, Mohamed Shoukri, Muhannad Alanazi
BACKGROUND: Currently, there are no data on the prevalence of breast arterial calcification (BAC) in Saudi women. Furthermore, there are no data on the relationship between BAC and coronary artery calcium score (CACS) as a coronary artery disease (CAD) risk factor in Saudi women who undergo mammography. OBJECTIVE: Examine the role of BAC as a potential female-specific risk factor for CAD in Saudi women in order to investigate the relationship between BAC and CACS in women who undergo a screening mammography, and study the relationship between BAC and CAD risk factors, including age, diabetes mellitus, hypertension, chronic kidney disease (CKD), dyslipidemia, and family history of CAD...
November 2018: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/30530865/tlr4-and-mmp2-polymorphisms-and-their-associations-with-cardiovascular-risk-factors-in-susceptibility-to-aortic-aneurysmal-diseases
#10
Tan Li, Jingjing Jing, Liping Sun, Bo Jiang, Shijie Xin, Jun Yang, Yuan Yuan
BACKGROUND: Toll-like receptor 4 (TLR4) and matrix metalloproteinase 2 (MMP2) play important roles in aortic pathophysiology. We aimed to evaluate the contribution of TLR4 and MMP2 polymorphisms individually and complex interactions between gene and risk factors in susceptibility to aortic aneurysm (AA) and its subtypes. METHODS: KASP method was adopted to detect TLR4rs11536889, rs1927914 and MMP2rs2285053 polymorphisms in 498 controls and 472 AA patients, including 212 abdominal AA (AAA) and 216 thoracic AA (TAA)...
December 7, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30529195/antipsychotic-induced-metabolic-alterations-recounting-the-mechanistic-insights-therapeutic-targets-and-pharmacological-alternatives
#11
REVIEW
Raghunath Singh, Yashika Bansal, Bikash Medhi, Anurag Kuhad
Atypical antipsychotics (AAPs) are the drug of choice in the management of mental illnesses by virtue of their advantage over typical antipsychotics i.e. least tendency of producing extrapyramidal motor symptoms (EPS) or pseudoparkinsonism. Despite the clinical efficacy, AAPs produces troublesome adverse effects, particularly hyperphagia, hyperglycemia, dyslipidemia weight gain, diabetes mellitus, insulin resistance and QT prolongation which further develops metabolic and cardiac complications with subsequent reduction in life expectancy, poor patient compliance, and sudden death...
December 7, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30527940/influence-of-multiple-stents-on-periprocedural-stroke-after-carotid-artery-stenting-in-the-carotid-revascularization-endarterectomy-versus-stent-trial-crest
#12
Brajesh K Lal, Gary S Roubin, Michael Jones, Wayne Clark, Ariane Mackey, Michael D Hill, Jenifer H Voeks, George Howard, Robert W Hobson, Thomas G Brott
BACKGROUND: In the Carotid Revascularization Endarterectomy versus Stent Trial (CREST), carotid artery atherosclerotic lesion length and nature of the lesions were important factors that predicted the observed difference in stroke rates between carotid endarterectomy and carotid artery stenting (CAS). Additional patient-related factors influencing CAS outcomes in CREST included age and symptomatic status. The importance of the operator's proficiency and its influence on periprocedural complications have not been well defined...
December 4, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30527052/dyslipidemia-is-a-major-factor-in-stem-cell-damage-induced-by-uncontrolled-long-term-type-2-diabetes-and-obesity-in-the-rat-as-suggested-by-the-effects-on-stem-cell-culture
#13
Maryam Masouminia, Robert Gelfand, Istvan Kovanecz, Dolores Vernet, James Tsao, Ruben Salas, Kenny Castro, Leila Loni, Jacob Rajfer, Nestor F Gonzalez-Cadavid
BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and the underlying histopathology when implanted into the corpora cavernosa, and were also imprinted with a noxious gene global transcriptional signature (gene-GTS), suggesting that this may interfere with their use as autografts in stem cell therapy. AIM: To ascertain the respective contributions of dyslipidemia and hyperglycemia to this MDSC damage, clarify its mechanism, and design a bioassay to identify the damaged stem cells...
December 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30526614/associations-between-epicardial-adipose-tissue-subclinical-atherosclerosis-and-high-density-lipoprotein-composition-in-type-1-diabetes
#14
Cristina Colom, David Viladés, Montserrat Pérez-Cuellar, Rubén Leta, Andrea Rivas-Urbina, Gemma Carreras, Jordi Ordóñez-Llanos, Antonio Pérez, Jose Luis Sánchez-Quesada
BACKGROUND: The pathophysiology of cardiovascular complications in people with type 1 diabetes (T1DM) remains unclear. An increase in epicardial adipose tissue (EAT) and alterations in the composition of high-density lipoprotein (HDL) are associated with coronary artery disease, but information on its relationship in T1DM is very limited. Our aim was to determine the association between EAT volume, subclinical atherosclerosis, and HDL composition in type 1 diabetes. METHODS: Seventy-two long-term patients with T1DM without clinical atherosclerosis were analyzed...
December 7, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/30524286/gastrodin-ameliorates-cognitive-dysfunction-in-diabetes-rat-model-via-the-suppression-of-endoplasmic-reticulum-stress-and-nlrp3-inflammasome-activation
#15
Tianyuan Ye, Xiangbao Meng, Yadong Zhai, Weijie Xie, Ruiying Wang, Guibo Sun, Xiaobo Sun
Patients with diabetes mellitus (DM) are at high risk for cognitive dysfunction. Endoplasmic reticulum stress (ERS) and inflammation play crucial roles in DM. Gastrodin (Gas), the main component of Gastrodia elata , possesses anti-oxidative stress, anti-inflammatory, and neuroprotective effects. This present study aims to investigate whether Gas could ameliorate cognitive dysfunction in DM and to explore its underlying mechanisms. Rats with streptozotocin-induced type 2 DM were used in this study. After administration of Gas for 5 weeks, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in serum, TNF-α, IL-1β, MDA and SOD in the hippocampus were measured...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30522855/clinical-relevance-of-different-handgrip-strength-indexes-and-cardiovascular-disease-risk-factors-a-cross-sectional-study-in-suburb-dwelling-elderly-chinese
#16
Hairui Yu, Xiaoyu Chen, Renwei Dong, Wen Zhang, Peipei Han, Li Kang, Yixuan Ma, Liye Jia, Liyuan Fu, Lin Hou, Xing Yu, Lu Wang, Xiaodong Zhu, Fengying Yang, Qi Guo
BACKGROUND: Reduced muscle strength, as measured by handgrip strength (HS), has been associated with an increased risk of cardiovascular disease (CVD). The aim of this study was to examine the association between different HS indexes and CVD risk factors in elderly Chinese individuals. We also determine optimal cutoffs of HS indexes for predicting CVD risk factors. METHODS: Data were obtained from 603 men and 789 women aged ≥60 years (average age 66.8 ± 6.4 y)...
December 3, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30522793/gestational-diabetes-mellitus-alters-dna-methylation-profiles-in-pancreas-of-the-offspring-mice
#17
Zhuangli Zhu, Xiongfeng Chen, Yiqing Xiao, Junping Wen, Jinyan Chen, Kun Wang, Gang Chen
Gestational diabetes mellitus (GDM), which has an increasing global prevalence, contributes to the susceptibility to metabolic dysregulation and obesity in the offspring via epigenetic modifications. However, the underlying mechanism remains largely obscure. The current study established a GDM mice model to investigate the alternations in the metabolic phenotypes and genomic DNA methylation in the pancreas of the offspring. We found that in the GDM offspring, intrauterine hyperglycemia induced dyslipidemia, insulin resistance, and glucose intolerance...
November 9, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30522708/-prevalence-and-risk-factors-of-sub-renal-abdominal-aortic-aneurysm-in-an-algerian-population-aged-over-60
#18
C Ouarab, M Brouri, J P Laroche, S Ayoub
INTRODUCTION: The prevalence of abdominal aortic aneurysm (AAA) in the general population in our country is not known, our aim was to evaluate it in patients over 60 years of age, to specify the risk factors and to evaluate the extension of aneurysmal disease and multisite subclinical atherosclerosis. METHODS: Descriptive, transversal, study collecting the data of a systematic ultrasound screening of sub-renal AAA in subjects receiving care in two Algerian hospital structures...
December 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/30522496/dyslipidemia-and-non-small-cell-lung-cancer-risk-in-chinese-population-a-case-control-study
#19
Bo Hao, Miaomei Yu, Chen Sang, Baochen Bi, Jiajun Chen
BACKGROUND: Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC). METHODS: Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC. Demographic and clinical data were obtained from patients' medical records and telephone interviews...
December 6, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30521744/pharmacological-treatment-of-obesity
#20
Aldo Ferreira-Hermosillo, Latife Salame-Khouri, Dalia Cuenca-Abruch
More than 70% of the population in Mexico is overweight or obese, affecting mainly people in productive age. Obesity is associated with the development of diseases that increase cardiovascular risk (diabetes mellitus, hypertension or atherogenic dyslipidemia), diseases that limit the quality of life of the patient (osteoarthrosis or sleep apnea) and even with the increase in the incidence of certain types of cancer (breast or colon). It is evident that the decrease of at least 5% of body weight induces improvement in all these factors; however, in some patients it is difficult to achieve this goal only with lifestyle modifications...
November 30, 2018: Revista Médica del Instituto Mexicano del Seguro Social
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