Carolina Medina-Gomez, John P Kemp, Niki L Dimou, Eskil Kreiner, Alessandra Chesi, Babette S Zemel, Klaus Bønnelykke, Cindy G Boer, Tarunveer S Ahluwalia, Hans Bisgaard, Evangelos Evangelou, Denise H M Heppe, Lynda F Bonewald, Jeffrey P Gorski, Mohsen Ghanbari, Serkalem Demissie, Gustavo Duque, Matthew T Maurano, Douglas P Kiel, Yi-Hsiang Hsu, Bram C J van der Eerden, Cheryl Ackert-Bicknell, Sjur Reppe, Kaare M Gautvik, Truls Raastad, David Karasik, Jeroen van de Peppel, Vincent W V Jaddoe, André G Uitterlinden, Jonathan H Tobias, Struan F A Grant, Pantelis G Bagos, David M Evans, Fernando Rivadeneira
Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD) regions in 10,414 children. The estimated SNP heritability is 43% (95% CI: 34-52%) for TBLH-BMD, and 39% (95% CI: 30-48%) for TB-LM, with a shared genetic component of 43% (95% CI: 29-56%)...
July 25, 2017: Nature Communications