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Radical Scavenger

Angela T S Wyse, Mateus Grings, Moacir Wajner, Guilhian Leipnitz
Sulfite oxidase (SO) deficiency is an autosomal recessive inherited neurometabolic disease caused by deficient activity of SO. It is biochemically characterized by tissue accumulation and high urinary excretion of sulfite, thiosulfate, and S-sulfocysteine. Severe neurological symptoms, including neonatal seizures, encephalopathy, and psychomotor retardation, are commonly observed in the affected patients, but the pathogenesis of the neurologic dysfunction is still poorly understood. In this minireview, we will briefly summarize the knowledge obtained from in vivo and in vitro findings from animal studies indicating that oxidative stress and mitochondrial dysfunction are involved in the pathophysiology of the brain damage in this disease...
December 5, 2018: Neurotoxicity Research
Hee-Jeong Kim, Bohkyung Kim, Eun-Gyung Mun, Soon-Yeon Jeong, Youn-Soo Cha
BACKGROUND/OBJECTIVES: Ginger, a root vegetable, is known to have antioxidant and antiobesity effects. Preparation, such as by steaming, can affect the chemical composition of prepared root vegetables or herbs and can change their functional activities. In the present study, we investigated the protective effects of steamed ginger against oxidative stress and steatosis in C57BL/6J mice fed a high-fat diet. MATERIALS/METHODS: The levels of polyphenols and flavonoids in two different extracts of steamed ginger, i...
December 2018: Nutrition Research and Practice
You-Suk Lee, Il Je Cho, Joo Wan Kim, Sun-Kyoung Lee, Sae Kwang Ku, Hae-Jeung Lee
BACKGROUND/OBJECTIVES: The honeysuckle berry (HB) contains ascorbic acid and phenolic components, especially anthocyanins, flavonoids, and low-molecular-weight phenolic acids. In order to examine the potential of HB as a hepatoprotective medicinal food, we evaluated the in vitro anti-oxidant and anti-inflammatory activities of Korean HB (HBK) and Chinese HB (HBC). MATERIALS/METHODS: Antioxidant and anti-inflammatory effects of the extracts were examined in HepG2 and RAW 264...
December 2018: Nutrition Research and Practice
Lakhwinder Singh, Surbhi Rana, Sidharth Mehan
The present study aimed to investigate the role of adenylyl cyclase activator in preventing diabetic nephropathy in rats. Renal function parameters, renal hypertrophy, lipid profile, markers of oxidative stress and free radical scavenging activities were assessed. Histopathology was performed to confirm Streptozotocin induced renal morphological changes in diabetic rats. Male Wistar rats were used in the present study to reduce the effect of estrogen. Rats were subjected to high fat diet (HFD) for two weeks followed by low dose of Streptozotocin (STZ) [35 mg/kg, i...
2018: International Journal of Physiology, Pathophysiology and Pharmacology
Hyojin Kim, Mi Sook Chung
Antiviral activities of Morus alba (MA) juice and seed were examined using time-of-addition plaque assays against influenza viruses, A/Brisbane/59/2007 (H1N1) (BR59), pandemic A/Korea/01/2009(H1N1) (KR01), A/Brisbane/10/2007(H3N2) (BR10), and B/Florida/4/2006 (FL04). MA juice (MAJ) showed much higher antiviral activity than MA seed (MAS). In the pre- and cotreatment of virus, MAJ showed antiviral effects against BR59, KR01, and FL04 in a dose-dependent manner. In particular, MAJ at 4% concentration exhibited 1...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Vassiliki T Papoti, Maria Papageorgiou, Konstantina Dervisi, Evangelos Alexopoulos, Konstantinos Apostolidis, Dimitrios Petridis
Quality characteristics of olive products significantly depend on cultivar (cv), among other factors. In this study, seven traditional, noncommercial Greek cultivars, along with the commercial Spanish Arbequina cv., were examined for the phenolic antioxidant dynamic of their leaves. Polar extracts (aqueous, methanol, and ethanol) were analyzed for Total Phenol (TP), Flavonoid (TFL), Hydroxycinnamic Acid Derivatives (THAD), Flavonol (TFLVN) contents, DPPH radical scavenging ability, and Ferric Reducing Capacity (FRAP)...
December 3, 2018: Foods (Basel, Switzerland)
Olívia R Pereira, Marcelo D Catarino, Andrea F Afonso, Artur M S Silva, Susana M Cardoso
Salvia elegans Vahl., Salvia greggii A. Gray, and Salvia officinalis L. decoctions were investigated for their health-benefit properties, in particular with respect to antioxidant activity and inhibitory ability towards key enzymes with impact in diabetes and obesity (α-glucosidase, α-amylase and pancreatic lipase). Additionally, the phenolic profiles of the three decoctions were determined and correlated with the beneficial properties. The S. elegans decoction was the most promising in regard to the antioxidant effects, namely in the scavenging capacity of the free radicals DPPH• , NO• and O₂•⁻ , and the ability to reduce Fe3+ , as well as the most effective inhibitor of α-glucosidase (EC50 = 36...
December 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Rie Takashima, Masaki Morishita, Toshiyasu Sakane, Akira Yamamoto
l-cysteine (Cys)- and l-serine (Ser)-modified, third-generation polyamidoamine (PAMAM) dendrimer with multiple reduced thiols (Ser-PAMAM-Cys) was synthesized as a kidney-targeting reactive oxygen species (ROS) scavenger to help prevent renal ischemia/reperfusion injury. Ser-PAMAM-Cys effectively scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and ROS (hydrogen peroxide and hydroxyl radical) in phosphate-buffered saline (PBS). In addition, ~64% of 111 In-labeled Ser-PAMAM-Cys accumulated in mouse kidney 3 h after intravenous administration...
December 1, 2018: Pharmaceutics
Peter Szabados-Furjesi, David Pajtas, Aliz Barta, Evelin Csepanyi, Attila Kiss-Szikszai, Arpad Tosaki, Istvan Bak
Six new flavonols ( 6a ⁻ f ) were synthesized with Claisen⁻Schmidt and Suzuki reactions and they were fully characterized by spectroscopic methods. In order to evaluate their antioxidant activities, their oxygen radical absorption capacity and ferric reducing antioxidant power were measured, along with their free radical scavenging activity against 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and 2,2-diphenyl-1-picrylhydrazylradicals. In addition, their cytotoxicity on H9c2 cardiomyoblast cells was also assessed by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
November 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yuwei Wang, Delin Qi, Shulin Wang, Xiaohai Cao, Ying Ye, Yourui Suo
Differences in the content of nine phenols and the antioxidant capacity of Ribes stenocarpum Maxim (RSM) fruits at different stages of maturity were investigated, and the extraction process of polyphenols from RSM was also optimized using Box-Behnken design method. Results showed that the content of the nine phenols varied considerably at different ripening stages; catechin, chlorogenic acid, coumaric acid, and ferulic acid were abundant in immature fruits but decreased with fruit ripening, whereas the levels of rosemary acid and querctin acid were low in immature fruits and increased with time, reaching the highest value after the fruit was completely mature...
November 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Farideh Tabatabaei Yazdi, Abbas Tanhaeian, Marjan Azghandi, Alireza Vasiee, Behrooz Alizadeh Behbahani, Seyed Ali Mortazavi, Sahar Roshanak
The antimicrobial peptide Thrombocidin-1 (TC-1) isolated from human blood that derived from NAP-2 by deleting of two amino acids from C-terminal region. In this study, a C-terminal 6 _ His tagged recombinant TC-1 was expressed as a secreted peptide in Pichia pastoris, for the first time. The recombinant P. pastoris was inoculated in to BMMY culture medium, incubation with 5 μl/ml absolute methanol for 72 h at 30 °C. The TC-1 peptide was concentrated with nickel affinity chromatography and electrophoresis on 16% acrylamide gels...
December 1, 2018: Microbial Pathogenesis
Masoud Nateqi, Sayid Mahdi Mirghazanfari
Ajowan, thyme and fenugreek are spice and aromatic crops with a number of medicinal properties which are known as important sources of essential phytochemicals. The purpose of this study was to investigate the antioxidant capacity, total phenolic content and antifungal activities of these plant extracts on growth of Fusarium solani, an important plant pathogen, soil saprophyte and one of the causal agents of fusariosis in human and animals. Their total antioxidant activity was measured using DPPH radical scavenging assay and their antimicrobial activity was determined through poison food assay at two concentrations (1000 and 1500 ppm) and spore germination assay in vitro...
November 30, 2018: Cellular and Molecular Biology
Tunay Karan
Medicinal and aromatic plants play a significant role in drug discovery. Lavandula stoechas L. has been used as folk medicine to treat various diseases. The aim of this work is to investigate the phytochemisty of Lavandula stoechas with biological activities. An aerial part of the plant was extracted with methanol. Another sample of plant was boiled in water then aqueous part was extracted with ethyl acetate. Identification and quantification of phenolic compounds, organic acids and flavonoids in methanol extract were carried out by High Performance Liquid Chromatography/Time of Flight/Mass Spectrometry, HPLC-TOF/MS...
November 30, 2018: Cellular and Molecular Biology
Celia Rodríguez-Pérez, Gokhan Zengin, Antonio Segura-Carretero, Devina Lobine, Mohamad Fawzi Mahomoodally
INTRODUCTION: In the quest for new sources of biologically-active compounds, the chemical, and biological profiles of two Globularia species (G. trichosantha Fisch. & C. A. Mey and G. orientalis L.) were investigated. METHODOLOGY: Chemical profiles were evaluated by high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS), as well as by their total phenolic, flavonoids, and phenolic acids contents...
December 3, 2018: Phytochemical Analysis: PCA
Noor Mamdooh, Violet Kasabri, Yusuf Al-Hiari, Ihab Almasri, Sundus Al-Alawi, Yasser Bustanji
In this study, 15 commercial acidic drugs have been evaluated for pancreatic lipase (PL) inhibitory activity using an in vitro spectrophotometric method. The acidity was the basis of selection, since most PL inhibitors exhibit acidic groups and high lipophilicity. Orlistat was the robust reference agent for potency and efficacy determinations. In comparison to the cisplatin, the evaluation of the antineoplastic activities of selected drugs in a panel of colorectal cancer cell lines (HT-29, HCT-116, SW620, CACO-2, and SW480) and normal periodontal ligament fibroblasts for safety examination was performed by using a sulforhodamine procuring ascorbic acid as a reference in diphenyl-2-picryl-hydrazyl assay of radical scavenging properties was performed...
December 3, 2018: Drug Development Research
Tarek K Abouzed, Kadry M Sadek, Mousa M Ayoub, Ebeed A Saleh, Sherif M Nasr, Yasser S El-Sayed, Moustafa Shoukry
Carica papaya is a perennial plant containing bioactive constituents with free radical-scavenging and immune-modulating activities. In contrast, the immune suppression is predominant in the periparturient period, where oxidative stress has a substantial impact on the mammary gland health. The aim of the experiment reported here was to determine the potential effect of C. papaya aqueous extract (CPE) on milk production traits, and expression of genes and proteins related to immune and antioxidant status in dairy milk somatic cells (MSCs)...
December 3, 2018: Journal of Animal Physiology and Animal Nutrition
Jihed Brahmi, Sana Bakari, Soumaya Nasri, Habib Nasri, Adel Kadri, Kaïss Aouadi
A new series of semicarbazone-triazole hybrid derivatives have been synthesized by condensation between heterocyclic aldehydes and the commercial semicarbazide hydrochloride. The in vitro antioxidant activity of these species was tested using 1,1-diphenyl-2-picrylhydrazyl radical, 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and Ferric reducing antioxidant power assays and their antimicrobial activity against different microbial strains was carried out. Furthermore, molecular properties prediction and drug likeness were also determinated using Molinspiration...
December 3, 2018: Molecular Biology Reports
Myung-Hee Lee, Tae Gyu Nam, Inil Lee, Eun Ju Shin, Ah-Ram Han, Pomjoo Lee, Sung-Young Lee, Tae-Gyu Lim
The aim of this study was to investigate the skin anti-inflammatory activity of rose petal extract (RPE) and the mechanisms underlying this phenomenon. Recently, flowers have been considered as dietary resources owing to their biological activities, such as inhibition of nephritis and hemorrhoids. The Rosa plant exerts various biological functions, including antioxidant and anti-microbiological activities. Herein, we confirmed the skin anti-inflammatory activity of RPE upon solar UV (sUV) exposure. RPE reduced sUV-induced COX-2 expression as well as expressions of several cytokines...
November 2018: Food Science & Nutrition
Sujun Wang, Ruinan Yang, Hui Li, Jun Jiang, Liangxiao Zhang, Qi Zhang, Peiwu Li
The radical scavenging capabilities of the extracts from eleven edible vegetable oils were investigated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-3- ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing ability of plasma (FRAP) assays. The results indicated that rapeseed oil and sesame oil showed higher radical scavenging abilities than other vegetable oils. When the radical scavenging capabilities of the extracts from virgin camellia oils and commercially available refined camellia oils were evaluated by FRAP assay, the results showed that the antioxidant capabilities of the former were higher than the latter...
November 2018: Food Science & Nutrition
Bukola C Adedayo, Adeniyi A Adebayo, Esther E Nwanna, Ganiyu Oboh
This study was designed to investigate the influence of cooking on the glycemic index (GI), amylose, and amylopectin contents of two rice varieties. Two rice varieties (foreign long rice and ofada) were sourced for, divided into two, one portion cooked and the other used raw. The sugar, starch, amylose, and amylopectin contents as well as glycemic indices, antioxidant properties, and the ability of the rice to inhibit carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase) were determined. In addition, polyphenol content was determined...
November 2018: Food Science & Nutrition
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