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https://www.readbyqxmd.com/read/30057367/episiotomy-practice-in-the-middle-east-a-lebanese-teaching-tertiary-care-center-experience
#1
Rima Kaddoura, Jocelyn DeJong, Huda Zurayk, Tamar Kabakian, Christine Abbyad, Fadi G Mirza
PROBLEM: There is lack of data on the rate of episiotomy in Lebanon and the study's hospital. BACKGROUND: Only a few studies have addressed episiotomy practice in Lebanon and the Middle East and they show varying rates. AIM: To identify the rate, and change in rate, of episiotomy practice over the years at a teaching hospital in Lebanon and to assess whether maternal age, parity, fetal weight, woman's hospital admission class, and physician's gender were associated with episiotomy...
July 26, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29970918/emergence-and-spread-of-carbapenem-resistant-acinetobacter-baumannii-international-clones-ii-and-iii-in-lima-peru
#2
Saúl Levy-Blitchtein, Ignasi Roca, Stefany Plasencia-Rebata, William Vicente-Taboada, Jorge Velásquez-Pomar, Laura Muñoz, Javier Moreno-Morales, Maria J Pons, Juana Del Valle-Mendoza, Jordi Vila
Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 non-duplicate clinical samples of A...
July 4, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29937453/functional-comparison-of-anoctamin-1-antagonists-on-human-uterine-smooth-muscle-contractility-and-excitability
#3
Shunsuke Hyuga, Jennifer Danielsson, Joy Vink, Xiao Wen Fu, Ronald Wapner, George Gallos
BACKGROUND: Pre-term birth is a major health care challenge throughout the world, and preterm labor represents a potentially reversible component of this problem. Current tocolytics do not improve preterm labor beyond 48 h. We have previously shown that anoctamin 1 (ANO1) channel blockade results in relaxation of pre-contracted human uterine smooth muscle (USM). Three drug classes with reported medicinal effects in humans also have members with ANO1 antagonism. In this study, we compared the ability of representatives from these 3 classes to reduce human USM contractility and excitability...
2018: Journal of Smooth Muscle Research, Nihon Heikatsukin Gakkai Kikanshi
https://www.readbyqxmd.com/read/29896113/heart-rate-variability-as-a-prognostic-factor-for-cancer-survival-a-systematic-review
#4
Evelyne Kloter, Katja Barrueto, Sabine D Klein, Felix Scholkmann, Ursula Wolf
An increasing cancer incidence affecting any age and social class is putting serious strain on populations and health care systems around the world. This systematic literature search aims (i) to examine the correlation of heart rate variability (HRV) and cancer patients' prognosis, (ii) to examine the relationship of HRV and clinicopathological features, and (iii) to compare HRV between different patient groups, and between patient and control groups. We conducted a systematic literature review following the PRISMA Statement...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29866724/a-pushing-chronic-care-forward-in-abu-dhabi-by-identifying-priorities-and-addressing-barriers-a-modified-delphi-technique
#5
Marília Silva Paulo, Tom Loney, Luis V Lapão
OBJECTIVE: This study aimed to elucidate the top five key priorities and barriers to chronic care in the health system of Abu Dhabi, United Arab Emirates (UAE). DESIGN: A modified Delphi study was performed to reach consensus on priority areas and barriers to the development of the Chronic Care Model in the health system of Abu Dhabi. Individual wireless audience response devices (keypads) linked to a computer were used to reduce 28 priorities and 20 barriers to the top five during three iterative rounds over three consecutive days...
June 4, 2018: BMJ Open
https://www.readbyqxmd.com/read/29862492/interventions-for-preventing-upper-gastrointestinal-bleeding-in-people-admitted-to-intensive-care-units
#6
REVIEW
Ingrid Toews, Aneesh Thomas George, John V Peter, Richard Kirubakaran, Luís Eduardo S Fontes, Jabez Paul Barnabas Ezekiel, Joerg J Meerpohl
BACKGROUND: Upper gastrointestinal (GI) bleeding due to stress ulcers contributes to increased morbidity and mortality in people admitted to intensive care units (ICUs). Stress ulceration refers to GI mucosal injury related to the stress of being critically ill. ICU patients with major bleeding as a result of stress ulceration might have mortality rates approaching 48.5% to 65%. However, the incidence of stress-induced GI bleeding in ICUs has decreased, and not all critically ill patients need prophylaxis...
June 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29806038/ethical-considerations-in-controlled-human-malaria-infection-studies-in-low-resource-settings-experiences-and-perceptions-of-study-participants-in-a-malaria-challenge-study-in-kenya
#7
Maureen Njue, Patricia Njuguna, Melissa C Kapulu, Gladys Sanga, Philip Bejon, Vicki Marsh, Sassy Molyneux, Dorcas Kamuya
Background: The range and amount of volunteer infection studies, known as Controlled Human Infection Model (CHMI) studies, in Low-Middle Income Countries (LMICs) is increasing with rapid technological advancement, world-class laboratory facilities and increasing capacity development initiatives. However, the ethical issues these studies present in LMICs have not been empirically studied. We present findings of a descriptive social science study nested within a malaria volunteer infection study, on-going at the time of writing, at the KEMRI-Wellcome Trust Research Programme (KWTRP) on the Kenyan Coast...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29777373/safety-and-feasibility-of-pulmonary-artery-pressure-guided-heart-failure-therapy-rationale-and-design-of-the-prospective-cardiomems-monitoring-study-for-heart-failure-mems-hf
#8
Christiane E Angermann, Birgit Assmus, Stefan D Anker, Johannes Brachmann, Georg Ertl, Friedrich Köhler, Stephan Rosenkranz, Carsten Tschöpe, Philip B Adamson, Michael Böhm
BACKGROUND: Wireless monitoring of pulmonary artery (PA) pressures with the CardioMEMS HF™ system is indicated in patients with New York Heart Association (NYHA) class III heart failure (HF). Randomized and observational trials have shown a reduction in HF-related hospitalizations and improved quality of life in patients using this device in the United States. OBJECTIVE: MEMS-HF is a prospective, non-randomized, open-label, multicenter study to characterize safety and feasibility of using remote PA pressure monitoring in a real-world setting in Germany, The Netherlands and Ireland...
May 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29695924/cardiovascular-effects-of-sodium-glucose-cotransporter-2-inhibitors
#9
REVIEW
Tricia Santos Cavaiola, Jeremy Pettus
As the first cardiovascular (CV) outcome trial of a glucose-lowering agent to demonstrate a reduction in the risk of CV events in patients with type 2 diabetes mellitus (T2DM), the EMPAgliflozin Removal of Excess Glucose: Cardiovascular OUTCOME Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME® ) trial, which investigated the sodium glucose cotransporter 2 (SGLT2) inhibitor empagliflozin, has generated great interest among health care professionals. CV outcomes data for another SGLT2 inhibitor, canagliflozin, have been published recently in the CANagliflozin CardioVascular Assessment Study (CANVAS) Program, as have CV data from the retrospective real-world study Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors (CVD-REAL), which compared SGLT2 inhibitors with other classes of glucose-lowering drugs...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29599104/physical-trauma-patients-with-symptoms-of-an-acute-and-posttraumatic-stress-disorder-protocol-for-an-observational-prospective-cohort-study
#10
Eva Visser, Taco Gosens, Brenda Den Oudsten, Jolanda De Vries
BACKGROUND: Injury, medical treatment, and rehabilitation can have major impacts on patients' wellbeing. About 25-33% of the patients experience an acute stress disorder (ASD) or a posttraumatic stress disorder (PTSD) after injury. ASD is a relatively new diagnosis. Therefore, knowledge about patients' experiences, the course of ASD and PTSD, and who is at risk for developing ASD or PTSD is lacking. OBJECTIVE: The aims of this multi-method study are to explore patients' experiences with injury (and their care) using a focus group study...
March 29, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29582950/-hadassah-medical-organization-a-pioneer-in-population-health
#11
REVIEW
Ronit Calderon-Margalit, Hagai Levine, Avi Israeli, Ora Paltiel
Population health is a term encompassing "the health outcomes of a group of individuals, including the distribution of such outcomes within the group." Only recently have hospitals viewed themselves as focal points for promoting health in a community, involving themselves with population health. Hadassah Medical Organization (HMO), however, has been in the business of population health since its founding. Its early programs, promoting and delivering nutritional support, maternal-child health and other services to the Yishuv's inhabitants, showed that the HMO defined its community broadly...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29530914/meta-salud-diabetes-study-protocol-a-cluster-randomised-trial-to-reduce-cardiovascular-risk-among-a-diabetic-population-of-mexico
#12
Samantha Sabo, Catalina Denman Champion, Melanie L Bell, Elsa Cornejo Vucovich, Maia Ingram, Celina Valenica, Maria Del Carmen Castro Vasquez, Eduardo Gonzalez-Fagoaga, Jill Geurnsey de Zapien, Cecilia B Rosales
INTRODUCTION: Northern Mexico has among the highest rates of cardiovascular disease (CVD) and diabetes in the world. This research addresses core gaps in implementation science to develop, test and scale-up CVD risk-reduction interventions in diabetics through a national primary care health system. METHODS AND ANALYSIS: The Meta Salud Diabetes (MSD) research project is a parallel two-arm cluster-randomised clinical behavioural trial based in 22 (n=22) health centres in Sonora, Mexico...
March 12, 2018: BMJ Open
https://www.readbyqxmd.com/read/29518081/study-of-diagnostic-accuracy-of-helmintex-kato-katz-and-poc-cca-methods-for-diagnosing-intestinal-schistosomiasis-in-candeal-a-low-intensity-transmission-area-in-northeastern-brazil
#13
Catieli Gobetti Lindholz, Vivian Favero, Carolina de Marco Verissimo, Renata Russo Frasca Candido, Renata Perotto de Souza, Renata Rosa Dos Santos, Alessandra Loureiro Morassutti, Helio Radke Bittencourt, Malcolm K Jones, Timothy G St Pierre, Carlos Graeff-Teixeira
Control initiatives have successfully reduced the prevalence and intensity of schistosomiasis transmission in several localities around the world. However, individuals that release low numbers of eggs in their feces may not be detected by classical methods that are limited by low sensitivity. Given that accurate estimates of prevalence are key to implementing planning control actions for the elimination of schistosomiasis, new diagnostic tools are needed to effectively monitor infections and confirm transmission interruption...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29504327/dengue-knowledge-in-indoor-dengue-patients-from-low-socioeconomic-class-aetiology-symptoms-mode-of-transmission-and-prevention
#14
Nadia Shams, Sadia Amjad, Nadeem Yousaf, Waqar Ahmed, Naresh Kumar Seetlani, Shazia Farhat
BACKGROUND: Dengue fever has emerged as an emerging public health issue during last decade bearing significant morbidity and economic burden particularly in third world countries. Current study aims to assess various domains of knowledge of indoor dengue patients.. METHODS: This descriptive crosssectional study was conducted at Medicine dept. Rawal Institute of Health Sciences Islamabad and BBH Rawalpindi over 6 months. One hundred & twenty-five adult indoor confirmed cases of dengue from lower socioeconomic class were included after ethical approval...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29436260/treatment-patterns-and-associated-health-care-costs-before-and-after-treatment-initiation-among-pulmonary-arterial-hypertension-patients-in-the-united-states
#15
Charles D Burger, A Burak Ozbay, Howard M Lazarus, Ellen Riehle, Leslie B Montejano, Gregory Lenhart, R James White
BACKGROUND: Despite multiple treatment options, the prognosis of pulmonary arterial hypertension (PAH) remains poor. PAH patients experience a high economic burden due to comorbidities, hospitalizations, and medication costs. Although combination therapy has been shown to reduce hospitalizations, the relationship between treatment, health care utilization, and costs remains unclear. OBJECTIVE: To provide a characterization of health care utilization and costs in real-world settings by comparing periods before and after initiating PAH-specific treatment...
February 13, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29403316/validation-of-modified-world-health-organization-classification-for-pregnant-women-with-heart-disease-in-a-tertiary-care-center-in-southern-thailand
#16
Chitkasaem Suwanrath, Putthaporn Thongphanang, Sutham Pinjaroen, Saranyou Suwanugsorn
Purpose: To validate the modified World Health Organization (WHO) classification in pregnant women with congenital and acquired heart diseases. Patients and methods: The database of pregnant women with heart disease, who delivered at Songklanagarind Hospital between January 1995 and December 2016, was retrieved from the Statistical Unit, Department of Obstetrics and Gynecology, along with the Hospital Information System of Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29362945/increasing-stroke-knowledge-and-decreasing-stroke-risk-in-a-latino-immigrant-population
#17
Mina Silberberg, Larry B Goldstein, Sarah Weaver, Colleen Blue
Stroke knowledge is poor and stroke risk is growing for the U.S. Latino immigrant population. We present results of an evaluation of a tailored, community-based intervention in Durham, North Carolina. The intervention included integration of stroke knowledge into classes and workshops at a community-based organization. Knowledge surveys were administered to participants immediately before and after stroke education, and at multiple points over the following year. For both low-risk participants receiving classroom-based education and individually care managed participants with risk factors, stroke knowledge improved dramatically and remained high among those who could be reached for follow-up...
January 23, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29357269/involving-a-real-patient-in-the-design-and-implementation-of-case-based-learning-to-engage-learners
#18
Bonny L Dickinson, Wendy Lackey, Maria Sheakley, Lisa Miller, Susan Jevert, Brandy Shattuck
Real patients offer unique opportunities to develop authentic, engaging, and transformative learning experiences for students. Patients are widely employed to teach clinical and interpersonal skills in the clerkship phase of their medical education (M3-M4), but have not been extensively included in the preclinical curriculum (M1-M2) when students are focused on acquiring foundational biomedical science knowledge. To maximize learning and help students connect foundational and clinical science concepts to real-world clinical problems, we involved a real patient in the creation and implementation of a case-based learning (CBL) activity in our preclinical curriculum...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29355886/antidepressants-for-depression-in-adults-with-hiv-infection
#19
REVIEW
Ingrid Eshun-Wilson, Nandi Siegfried, Dickens H Akena, Dan J Stein, Ekwaro A Obuku, John A Joska
BACKGROUND: Rates of major depression among people living with HIV (PLWH) are substantially higher than those seen in the general population and this may adversely affect antiretroviral treatment outcomes. Several unique clinical and psychosocial factors may contribute to the development and persistence of depression in PLWH. Given these influences, it is unclear if antidepressant therapy is as effective for PLWH as the general population. OBJECTIVES: To assess the efficacy of antidepressant therapy for treatment of depression in PLWH...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29338440/selective-progesterone-receptor-modulators-current-applications-and-perspectives
#20
N Chabbert-Buffet, K Kolanska, E Daraï, P Bouchard
Selective progesterone receptor modulators (SPRMs) are steroid progesterone receptor ligands able to induce agonistic or antagonistic activities. Mifepristone, the class leader, was primarily used for pregnancy termination from the 1980s. Emergency contraception with extended activity was the second major development 30 years later, with mifepristone in some countries and ulipristal acetate world-wide. More recently, ulipristal acetate was released for the treatment of myoma-related uterine bleeding. In addition to a very rapid cessation of bleeding, SPRMs allow a decrease in myoma volume, as do gonadotropin releasing hormone analogs...
August 2018: Climacteric: the Journal of the International Menopause Society
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