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Levent Trabzonlu, Nadir Paksoy
Follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common subtype of papillary thyroid carcinoma (PTC) after classical PTC (cPTC). Follicular thyroid lesions such as follicular adenomas/carcinomas, FVPTC, and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) pose some diagnostic challenges for FNAC. In this study, we aimed to explore whether FNAC can demonstrate diagnostic clues by re-evaluating cytology slides from histopathologically diagnosed FVPTC cases...
October 12, 2018: Endocrine Pathology
Robin Bacher, Melanie Hohberg, Markus Dietlein, Markus Wild, Carsten Kobe, Alexander Drzezga, Matthias C Schmidt
Adjuvant radioiodine therapy (RITh) for differentiated thyroid carcinoma is performed either with thyroid hormone withdrawal or with administration of recombinant human thyroid-stimulating hormone (rhTSH). Heterogeneous results have been obtained on the impact of the method of patient preparation on thyroid uptake and whole-body effective half-life. A higher radiation exposure using thyroid hormone withdrawal for several weeks compared to rhTSH was reported in prior studies. It was the aim to examine if these findings are reproducible in a modern protocol with a short interval between surgery and RITh...
October 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Veljko Strajina, Benzon M Dy, Travis J McKenzie, Zahraa Al-Hilli, Robert A Lee, Mabel Ryder, David R Farley, Geoffrey B Thompson, Melanie L Lyden
BACKGROUND: There is a paucity of data regarding optimal treatment options and outcomes for recurrent disease after lateral neck dissection in patients with papillary thyroid carcinoma. METHODS: Retrospective review of patients who underwent either percutaneous ethanol injection or surgery for first-time ipsilateral recurrences after ipsilateral lateral neck dissection for papillary thyroid carcinoma was performed. RESULTS: Follow-up data were available for 54 patients with recurrences in 57 lateral necks treated by either percutaneous ethanol injection (n = 32) or surgery (n = 25)...
October 9, 2018: Surgery
Kyeong Hwa Ryu, Hye Jin Baek, Soo Buem Cho, Hyo Jung An, Jin Pyeong Kim
RATIONALE: Lymphatic embolization is a minimally invasive treatment option for managing chyle leakage after nodal dissection in the neck. After the procedure, the embolic material may cause foreign body granulomatous lymphadenitis and can be a diagnostic challenge for radiologists because of sonographic similarity to metastatic lymph node. Herein, we describe a clinical case of granulomatous lymphadenitis due to embolic material mimicking nodal metastasis detected on ultrasonography (US) with cytologic findings in a patient with thyroid cancer who underwent lymphatic embolization to treat chyle leakage after total thyroidectomy and neck dissection...
October 2018: Medicine (Baltimore)
Hong Kyu Kim, Hoon Yub Kim, Young Jun Chai, Gianlorenzo Dionigi, Eren Berber, Ralph P Tufano
INTRODUCTION: The surgical outcomes for procedures using da Vinci Xi were compared with those of da Vinci Si in transoral robotic thyroidectomy (TORT). MATERIALS AND METHODS: The medical records were retrospectively reviewed. Patients were classified into 2 groups (da Vinci Xi vs. da Vinci Si) and surgical outcomes were analyzed. RESULTS: Each group comprised 58 patients. The postoperative pain scores at operation day 0 were lower, the hospital stays were shorter, and the number of retrieved central lymph nodes in the papillary thyroid carcinoma patients were greater in the Xi group than in the Si group...
October 11, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Kwangsoon Kim, Won Woong Kim, Jung Bum Choi, Min Jhi Kim, Cho Rok Lee, Jandee Lee, Sang-Wook Kang, Kee-Hyun Nam, Woong Youn Chung, Jong Ju Jeong
Purpose: Recently, the American Thyroid Association (ATA) dynamic risk stratification (DRS) has been verified to be more valuable than the static anatomical staging system for predicting prognosis in patients with differentiated thyroid carcinoma (DTC). The purpose of this retrospective study was to compare the clinical usefulness of DRS, which is based on the response to initial treatment, with that of ATA initial risk stratification in pediatric patients. Methods: A total of 144 pediatric patients underwent thyroid operation from August 1982 to December 2013 at Yonsei University Hospital (Seoul, Korea)...
October 2018: Annals of Surgical Treatment and Research
Michael S Toss, Kim Billingham, Isioma U Egbuniwe, Filipa Moreno, Areeg Abass, Emad A Rakha
BACKGROUND: Papillary tumours of the breast are diagnostically challenging lesions and represent a wide spectrum of diseases from papilloma to invasive papillary carcinoma. A rare subtype of breast papillary tumour resembling the tall cell variant of thyroid papillary carcinoma (BTRTPC) has been described. The nomenclature of this entity, its relationship to other papillary tumours, and its nature, whether in situ or invasive, remain unclear. METHODS: Seventy-five papillary carcinomas (PCs) of the breast previously diagnosed in routine practice were reviewed and the presence of features (n = 10) characteristic of BTRTPC were assessed to determine whether BTRTPC comprises a distinct entity or is part of the spectrum of the previously defined PC variants...
October 11, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Ho Jin Son, Jeong Kyu Kim, Young Do Jung, Gyu Ho Jang, Youn Tae Seo, Deok Su Kim, Sung Hwan Park, Young Ju Jeong
BACKGROUND: There have been arguments over the efficacy of elective unilateral central neck dissection (CND) in patients with papillary thyroid carcinoma (PTC) <1 cm who underwent hemithyroidectomy. This study was designed to investigate locoregional recurrence and postoperative complications related to elective unilateral CND for papillary thyroid microcarcinoma (PTMC). METHODS: Five hundred thirty-seven patients who underwent hemithyroidectomy, with or without CND for PTMC, were included...
October 10, 2018: Head & Neck
Jeong-Hwa Choi, Jeonghee Lee, Sarah Yang, Eun Kyung Lee, Yul Hwangbo, Jeongseon Kim
Type 2 taste receptors (T2Rs, TAS2Rs) mediate bitterness perception and are involved in diverse defence mechanisms in extraoral tissues. The thyrocyte-expressed T2Rs control thyroid hormone production, and this regulatory role may be associated with susceptibility to thyroid diseases. This study examined whether the variations in TAS2Rs modify the risk of papillary thyroid carcinoma (PTC) and whether such T2R-related PTC risk is associated with genetically modified thyroid function. We conducted a case-control study with 763 Korean females, including 250 PTC cases...
October 9, 2018: Scientific Reports
Flávia O Valentim, Bárbara P Coelho, Hélio A Miot, Caroline Y Hayashi, Danilo T A Jaune, Danilo T A Oliveira, Mariângela E A Marques, José Vicente Tagliarini, Emanuel C Castilho, Paula Soares, Gláucia M F S Mazeto
Background: Computerized image analysis seems to represent a promising diagnostic possibility for thyroid tumors. Our aim was to evaluate the discriminatory diagnostic efficiency of computerized image analysis of cell nuclei from histological materials of follicular tumors. Methods: We studied paraffin-embedded materials from 42 follicular adenomas (FA), 47 follicular variants of papillary carcinomas (FVPC) and 20 follicular carcinomas (FC) by the software ImageJ...
August 1, 2018: Endocrine Connections
N Siddhartha Chakravarthy, Anuradha Chandramohan, Anne Jennifer Prabhu, M Gowri, Pavithra Mannam, N K Shyamkumar, Dukhabandhu Naik, A J Cherian, Nihal Thomas, M J Paul, Deepak Abraham
Aims and Objectives: The aim of the study is to examine the adequacy and accuracy of ultrasound-guided fine-needle aspiration cytology (US-FNAC) in thyroid nodules ≥1 cm and to analyze the clinical, sonological, and cytological features in predicting thyroid malignancy. Materials and Methods: US-FNAC was done on 290 patients from December 2013 to December 2014 by the radiologist. The Thyroid Imaging Reporting and Data System (TIRADS) was used to record the sonological features...
September 2018: Indian Journal of Endocrinology and Metabolism
Katie Dennis, Maura O'Neil, Anthony Harrington
We report a case of a 65-year-old female who had a total thyroidectomy 12 years ago for papillary thyroid carcinoma (PTC) who presented with a recurrent thyroid bed mass. Fine-needle aspiration biopsy yielded malignant cells, consistent with squamous cell carcinoma (SCCa). Surgical resection was performed, and histologic evaluation of the mass showed mixed PTC and SCCa. The tumor cells were positive for BRAF V600E mutation. Thyroid carcinomas with admixed papillary carcinoma and SCCa are rare and are associated with aggressive behavior, high rates of metastasis, and poor outcomes...
2018: CytoJournal
Y Zhang, Q L Wu, J P Yun
In recent years, the incidence of thyroid carcinoma gradually increased in China. The pathology diagnosis and classification was based on WHO classification of Tumors of Endocrine Organs, the third edition which published in 2004. The fourth edition, WHO classification of Tumors of Endocrine Organs was published in July 2017. Compared with the third, some important aspects (or points) were revised: the ICD-O code of hyalinizing trabecular tumor was changed from 0 to 1; three other encapsulated follicular-patterned thyroid tumors were added; the variants of well differentiation thyroid carcinoma (including papillary carcinoma and follicular carcinoma ) which was originated from thyroid epithelial cells were updated; oncocytic cell tumors were separated from follicular tumors; the ICD-O code of ectopic thymoma was changed from 1 to 3...
September 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Ali Erhan Kayalar, Eylem Eren Eyupoglu, Seda Akyildiz, Askin Esen Hasturk, Abdurrahman Bakir
Calvarial and dural metastases of papillary thyroid carcinomas (PTC) are rarely reported in the medical literature. Most frequent calvarial metastases are seen to originate from lung, breast, and prostate cancers. Thyroid cancer metastases are generally well vascularized and cause destruction in the bone tissues. First choice of treatment in distant metastases of PTC is surgery and radioactive iodine treatment for the primary cause. Postsurgical radiotherapy is used in accepted and suitable patients.
October 2018: Journal of Craniofacial Surgery
Ming Fang, Wenlong Huang, Xinchi Wu, Yuan Gao, Jing Ou, Xiaolan Zhang, Yanyun Li
MicroR-141-3p has been found to be down-regulated in papillary thyroid carcinoma (PTC), while little is known about the cellular functions and precise signals elicited by miR-141-3p in PTC. The results of this study indicated that the expression of miR-141-3p was aberrantly down-regulated in PTC tissues and cell lines, compared with the adjacent normal tissues and normal thyroid epithelial cells. Furthermore, the miR-141-3p expression level was negatively associated with TNM stage and lymph node metastasis in PTC...
October 5, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Xin Wu, Binglu Li, Chaoji Zheng, Xiaodong He
OBJECTIVES: Papillary thyroid carcinoma with a maximum tumor diameter no more than 10 mm is defined as papillary thyroid microcarcinoma (PTMC). The proportion of newly diagnosed PTMC has increased significantly in recent years. Different guidelines have different comments about optimal management of PTMC, especially on prophylactic central lymph node (CLN) dissection. The aim of the present study is to analyze the risk factors for CLN metastases in patients with PTMC. METHODS: A total of 4389 patients underwent thyroid surgery at our center from January 2017 to March 2018, and 2129 patients with PTMC were selected and assessed retrospectively...
October 5, 2018: Endocrine Practice
Kanika Singh, Mukta Pujani, Varsha Chauhan, Charu Agarwal, Shruti Dhingra
Papillary thyroid carcinoma (PTC) arising within follicular adenoma is a rare histological subset of papillary carcinoma. A 24-year-old female (euthyroid and asymptomatic) presented with a solitary mass in the right lobe of thyroid for 2 years. Fine-needle aspiration cytology (FNAC) suggested features of hyperplasia of thyroid. Hemithyroidectomy was performed. Histopathological examination revealed two distinct areas and was reported as encapsulated variant of papillary carcinoma along with follicular adenoma...
September 2018: Indian Journal of Surgical Oncology
Jianlu Song, Shouxin Wu, Xiaotian Xia, Yu Wang, Youben Fan, Zhili Yang
BACKGROUND: Approximately half of the documented increases in differentiated thyroid carcinoma is due to identification of papillary thyroid microcarcinomas (PTMCs). Knowing whether PTMC is aggressive is required for proper treatment, but until now, there has been no method for assessing these traits and understanding the underlying mechanisms for aggressiveness. METHODS: We performed whole-exome sequencing of 16 PTMCs and matched normal thyroid tissues and GO/KEGG analysis to study genetic alterations and biological consequences associated with aggressive PTMCs, and then sequenced these genes using a next-generation gene-panel approach in an additional 70 PTMC samples including aggressive (n = 50) and non-aggressive (n = 20) groups...
October 1, 2018: Journal of Translational Medicine
Khalid S Aljabri, Samia A Bokhari, Muneera A Al, Patan Murthuza Khan
BACKGROUND: Thyroid carcinoma (TC) is the ninth most common site of all cancers in women in the world and the second most common malignancy in Saudi Arabia. This reports updates data on the epidemiology of the disease in Saudi Arabia. OBJECTIVE: Describe and interpret changes in the frequency of TC to compare with other populations and determine proportions of certain histological types of TC. DESIGN: Medical record review. SETTING: Military hospital in Jeddah, Saudi Arabia...
September 2018: Annals of Saudi Medicine
Helmi Khadra, Ahmed Deniwar, Khuzema Mohsin, Dominique Monlezun, Emad Kandil
Background: Papillary thyroid carcinoma (PTC) can be predicted from certain suspicious ultrasound (US) features of thyroid nodules. The aim of this study was to examine if these suspicious features can predict the more aggressive PTC associated with B-type Raf kinase (BRAFV600E) mutation. Methods: This was a retrospective review of prospectively collected data on patients with PTC and known BRAFV600E status. All patients underwent preoperative US by the same surgeon who performed all the operations...
August 2018: European Thyroid Journal
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