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Yu-Mi Lee, Jae Won Cho, Suck Joon Hong, Jong Ho Yoon
BACKGROUND AND OBJECTIVES: This study aimed to validate the dynamic risk stratification (DRS) system, evaluate its correlation with structural recurrence, and assess the clinicopathological risk factors associated with a nonexcellent response to initial therapy in patients with papillary thyroid cancer (PTC) measuring 1 to 4 cm. METHODS: A total of 762 patients with classic PTC measuring 1 to 4 cm were classified into four categories based on their response to initial therapy 2 years postoperatively...
August 16, 2018: Journal of Surgical Oncology
Jae Hyun Park, Yu-Mi Lee, Yi Ho Lee, Suck Joon Hong, Jong Ho Yoon
BACKGROUND: This study was undertaken to determine the optimal thyroid-stimulating hormone (TSH) value associated with structural recurrence in patients with low-risk or intermediate-risk papillary thyroid carcinoma (PTC) who underwent thyroid lobectomy. METHODS: Patients with PTC (n = 1047) who received thyroid lobectomy and central compartment node dissection were included in the study. RESULTS: Structural recurrence occurred in 42 of the patients (4...
August 16, 2018: Journal of Surgical Oncology
Mahdi Haghighatafshar, Fatemeh Shekoohi-Shooli
A 47-year-old female diagnosed with well-differentiated papillary thyroid carcinoma was referred to our center for a 131 Iodine whole body scintigraphy as follow-up. The patient had been previously treated with total thyroidectomy and ablative dose of 175mCi 131 I three years ago. Diagnostic 131 I scan showed a zone of radioiodine uptake in posterior aspect of the left upper quadrant of the abdomen. Spiral abdominal and pelvic CT scan showed an enhancing solid mass in superior aspect of the left adrenal gland, which was in favor of metastasis to the lymph node or an adrenal tumor...
October 2018: Radiology Case Reports
Zhibao Liu, Jinghua Zhang, Jinghua Gao, Yunnan Li
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer that accounts for 85% of thyroid cancers. MicroRNAs (miRNAs) have been reported to play important roles in the biological processes in cancer. In this study, we analyzed the biological role of miR-4728 in human PTC process in human PTC cell lines in vitro. MiRNA-4728 was observed to down-regulated in human PTC tissues and PTC cell lines. Additionally, miR-4728 inhibited PTC cell proliferation. Further study demonstrated SOS1 was repressed by miR-4728 and overexpression of miR-4728 down-regulated both the mRNA and protein levels of SOS1...
July 2018: Saudi Journal of Biological Sciences
Yu-Ming Xu, Zhao-Jian Gong, Han-Jiang Wu
The incidence of papillary thyroid carcinoma (PTC) incidentally found in the cervical lymph nodes during neck dissection for patients with tongue squamous cell carcinoma (SCC) is infrequent, with the coexistence of PTC and SCC in the same cervical lymph node being the rarest. Some of these patients present with primary lesions in the thyroid gland, whereas others have no obviously malignant thyroid lesion. The reasons behind this clinical phenomenon and the relationship between tongue SCC and PTC found in the cervical lymph nodes are unclear...
July 20, 2018: Journal of Oral and Maxillofacial Surgery
Ilana Slutzky-Shraga, Yulia Sternov, Eyal Robenshtock, Gloria Tzvetov, Carlos Benbassat, Dania Hirsch
OBJECTIVE: The accurate diagnosis of thyroid follicular/Hürthle cell tumors is challenging and a matter of controversy. We present a series of patients in whom a misclassification of follicular/Hürthle cell thyroid lesions as benign has led to devastating clinical outcomes. METHODS: The Thyroid Cancer Registry of Rabin Medical Center was screened for patients with metastatic differentiated thyroid carcinoma (DTC) who had been initially diagnosed with benign follicular lesion between 1974 and 2015 and treated with hemithyroidectomy...
August 14, 2018: Endocrine Practice
F A Offner, C Langner
Heterotopia of the gastrointestinal tract is a common finding. This is due to the complex embryogenesis and the relative ease to detect heterotopic tissue during endoscopy. The reason for biopsy is mostly to rule out neoplasms or to define specific causes of inflammation. Heterotopic tissue can occur in any location of the gastrointestinal tract. The most frequent are gastric heterotopia, pancreatic heterotopia, and heterotopia of Brunner's gland. On rare occasions, heterotopic tissue of salivary gland type as well as heterotopias of apocrine glands, thyroid, and prostatic tissue have been described...
August 13, 2018: Der Pathologe
Dengke Teng, Lei Ding, Yu Wang, Caimei Liu, Yongxu Xia, Hui Wang
PURPOSE: To evaluate the safety and efficiency of microwave ablation (MWA) with low power of 20 w, respectively, in the treatment of cervical metastatic lymph node (CMLN) from papillary thyroid carcinoma (PTC) with a mean of 32-month follow-up. METHODS: Eleven patients in total with 24 cervical lymph nodes (LNs) diagnosed with CMLN from PTC underwent MWA at a power of 20 w. We recorded images of the LNs under ultrasound first before MWA and 1, 3, 6, 12, months after MWA, and then every 6 months, respectively...
August 13, 2018: Endocrine
Oscar R Vázquez, Frieda Silva, Eduardo Acosta-Pumarejo, Maria L Marín
Ectopic thyroid tissue is a rare clinical entity wherein malignant lesions may arise, the most common one being papillary carcinoma. We present a case of a 68-year-old female who presented with a growing mass in the right clavicle. An MR of the shoulder showed a soft tissue mass arising from the anterior margin of the right distal clavicle. A fine needle aspiration of the mass showed papillary thyroid carcinoma. PET/CT confirmed the clavicular and mediastinal mass. Excision of the clavicular mass and total thyroidectomy with modified right neck dissection were performed...
2018: Case Reports in Endocrinology
Immacolata Cristina Nettore, Annamaria Colao, Paolo Emidio Macchia
Several epidemiological studies suggest an increased incidence of thyroid carcinoma (TC) in recent years, especially for the papillary histotype (PTC), suggesting that specific carcinogens might promote molecular abnormalities that are typical of PTC. The increased incidence is probably attributed to more intensive and sensitive diagnostic procedures, even if recent data suggest that various toxic elements could explain the phenomenon. Ionizing radiation exposure represents the most accepted risk factor for differentiated thyroid cancer that includes both the follicular and papillary histotypes...
August 13, 2018: International Journal of Environmental Research and Public Health
Ming-Nan Chien, Po-Sheng Yang, Yi-Chiung Hsu, Tsang-Pai Liu, Jie-Jen Lee, Shih-Ping Cheng
BACKGROUND: Telomerase reverse transcriptase (TERT) promoter mutations have recently been identified as an important prognostic factor in thyroid cancer. Studies suggest that TERT may have noncanonical functions beyond telomere maintenance. METHODS: Clinicopathological information and transcriptome data for papillary thyroid carcinoma (PTC) samples were obtained from The Cancer Genome Atlas (TCGA). Propensity score matching was performed to adjust for potential confounding variables between the TERT promoter wild-type group and the mutant group...
August 13, 2018: Head & Neck
Jie Chen, Xiao-Long Li, Chong-Ke Zhao, Dan Wang, Qiao Wang, Ming-Xu Li, Qing Wei, Guo Ji, Hui-Xiong Xu
The study was aimed at evaluating the correlation between central cervical lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) patients and ultrasound (US) features, immunohistochemical factors and BRAFV600E mutation. A total of 225 consecutive patients (225 PTCs) who had undergone surgery were included. All PTCs were pre-operatively analysed by US with respect to size, components, echogenicity, shape, margins, microcalcification, multiple cancers or not, internal vascularity and capsule contact or involvement...
August 9, 2018: Ultrasound in Medicine & Biology
Melissa L Mao, Thomas Joyal, Omar Picado, Darcy Kerr, John I Lew, Josefina C Farrá
BACKGROUND: The reclassification of noninvasive encapsulated follicular variant papillary thyroid carcinoma (FVPTC) to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) may have significant implications by changing overall malignancy rates and minimizing the extent of surgical treatment. METHODS: A retrospective review of 847 patients who underwent thyroidectomy at a single institution from January 2010 to April 2016 was performed...
October 2018: Journal of Surgical Research
Qinghai Peng, Chengcheng Niu, Qianrong Zhang, Meixiang Zhang, Sijie Chen, Qiang Peng
OBJECTIVES: The purpose of our study was to highlight the conventional and contrast-enhanced ultrasound (US) features of mummified thyroid nodules, which should help differentiate them from histologically proven papillary thyroid carcinomas (PTCs). METHODS: Thirty-one patients with 33 mummified thyroid nodules, which showed suspicious US findings that were suggestive of malignancy, as well as 33 patients with 38 surgically confirmed PTCs were enrolled in this study...
August 12, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Hirotaka Inoue, Naoki Shinojima, Ryuta Ueda, Shigetoshi Yano, Keizo Yamamoto, Norio Ishii, Motoyuki Igata, Junji Kawashima, Eiichi Araki, Hirotaka Iwase, Yoshiki Mikami, Akitake Mukasa
BACKGROUND: Thyroid-stimulating hormone (TSH)-secreting pituitary adenomas (TSHomas) are uncommon, and majority of the patients present with symptoms of hyperthyroidism. Herein, we report the first case of TSHoma with DTC that presented with visual disturbance without any clinical feature of hyperthyroidism. CASE DESCRIPTION: A 57-year-old man presented with left temporal hemianopsia of his left eye without any sign of hyperthyroidism. A mass lesion in the sellar and suprasellar region compressing the optic nerves was identified via magnetic resonance imaging...
August 7, 2018: World Neurosurgery
Arun Kadamkulam Syriac, Murtaza Mirza, Ashley Rose Malekunnel, Alberto Locante, Palak Desai
Thyroid malignancies are one of the fastest growing cancers in the world, with the majority being papillary thyroid cancer. Follicular variant of papillary thyroid cancer accounts for about 10%-20% of papillary thyroid carcinomas. The usual sites for metastases of these tumours are lungs and bones with renal metastases being extremely rare. We describe a case of a 64-year-old woman who presented with abdominal pain. On subsequent imaging, she was found to have a colonic mass with metastatic lesions in the lungs and tumour involving left kidney...
August 9, 2018: BMJ Case Reports
Kazuhiro Shimura, Hironori Shibata, Yusuke Mizuno, Naoko Amano, Ken Hoshino, Tatsuo Kuroda, Kaori Kameyama, Michiko Matsuse, Norisato Mitsutake, Kiminori Sugino, Jaeduk Yoshimura Noh, Tomonobu Hasegawa, Tomohiro Ishii
BACKGROUND: The risk factors for rapid growth and early metastasis of papillary thyroid carcinoma (PTC) and the role of coexisting Graves' disease in the clinical course of PTC remain uncertain in children. CASE DESCRIPTION: We report on a Japanese girl, whose PTC rapidly grew and metastasized within 4 years. Graves' disease was diagnosed by the presence of serum TSH receptor antibodies at 8 years of age when thyroid ultrasonography detected no nodules. After 4 years of effective treatment with thiamazole, multifocal nodules - up to 47 mm in diameter - were detected on thyroid ultrasonography...
August 9, 2018: Hormone Research in Pædiatrics
C Burton Wood, Jo-Lawrence Bigcas, Ibrahim Alava, Lindsay Bischoff, Alexander Langerman, Young Kim
OBJECTIVES: Thyroglossal duct cyst (TGDC) is the most common congenital neck mass, presenting in up to 7% of the population. TGDC carcinoma is much less common, occurring in roughly 1% of patients diagnosed with TGDC. The vast majority of these tumors are papillary-type thyroid cancer. Given its rarity, there is wide variation in management recommendations for this disease. Extent of surgical management and need for adjuvant therapy including radioactive iodine ablation (RAI) are particularly debated, with some authors arguing aggressive therapy including RAI for any patients who undergo concurrent thyroidectomy with the Sistrunk procedure for TGDC carcinoma...
August 9, 2018: Annals of Otology, Rhinology, and Laryngology
Geethalakshmi Sampathkumar, Vasantha Nair, Usha V Menon, N V Smitha, Shanmuga Sundaram, Harish Kumar, Praveen V Pavithran, Nisha Bhavani, Arun S Menon, Nithya Abraham, Annie Pullikkal
Context: Papillary thyroid carcinoma with tall cell histology (PTC-TCH) is an aggressive subtype in terms of clinicopathological features and outcome. Even 10% of tall cells can show aggressive features. Aims: The aim of this study is to investigate the behavior of PTC-TCH, to compare with classic PTC (cPTC), and evaluate the short-term outcome. Settings and Design: This is a retrospective analysis of patients with cPTC and those with TCH (PTC-TCH) seen from January 2010 to May 2017 seen in our Thyroid Cancer Clinic...
May 2018: Indian Journal of Endocrinology and Metabolism
Nelson George, Amit Agarwal, Niraj Kumari, Sarita Agarwal, Narendra Krisnani, Sushil Kumar Gupta
Introduction: Encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) has been reclassified into noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive EFVPTC. NIFTP is considered a low-risk neoplasm. Therefore, follicular variant of papillary thyroid cancer (FVPTC) presently has two distinct histopathological subtypes - invasive EFVPTC and infiltrative/diffuse FVPTC. Molecular characteristics of these groups remain unclear. Methodology: Thirty FVPTCs (10 NIFTPs, 12 invasive EFVPTCs, and 8 infiltrative/diffuse variants) were reviewed and screened for BRAF and RAS mutations by restriction fragment length morphism-polymerase chain reaction (PCR) and Sanger sequencing...
May 2018: Indian Journal of Endocrinology and Metabolism
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