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https://www.readbyqxmd.com/read/30114390/fos-like-antigen-2-fosl2-promotes-metastasis-in-colon-cancer
#1
Bing-Yuan Fei, Xiu-Ying Wang, Xue-Dong Fang
Among different cancers, incidence and mortality of colorectal cancer (CRC) is one of the highest. KRAS mutation is one of the underlying features in the pathogenesis of CRC with CRC tumors harboring mutant KRAS exhibiting a more aggressive behavior compared to CRC tumors with wild type KRAS. We had earlier shown that the microRNA-143 (miR-143) replenishment not only chemosensitizes CRC cell line with mutant KRAS instead of wild-type KRAS gene, to paclitaxel-mediated cytotoxicity, but also inhibits cell migration and invasion ability...
August 13, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30086463/mir-133a-acts-as-an-anti-oncogene-in-hepatocellular-carcinoma-by-inhibiting-fosl2-through-tgf-%C3%AE-smad3-signaling-pathway
#2
Lu Sun, Zhixian Guo, Jihong Sun, Jingjing Li, Zihui Dong, Yize Zhang, Jianan Chen, Quancheng Kan, Zujiang Yu
Hepatocellular carcinoma (HCC), one of the most common maligant cancers in the world, is difficult to diagnose in the early time. MicroRNAs (miRNAs), small non-coding RNAs, perform vital functions in cellular differentiation, metabolism and physiological processes. MiR-133a acts as a tumor suppressor in breast, lung and gastric cancer, while the molecular circadian mechanism has not been clear in HCC. In the present study, we certified that the expression of miR-133a decreased in HCC tissues and cell lines and that miR-133a inhibited proliferation, migration and invasion of hepatocellular carcinoma cells...
August 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30081074/identification-of-transcription-factors-responsible-for-dysregulated-networks-in-human-osteoarthritis-cartilage-by-global-gene-expression-analysis
#3
Kathleen M Fisch, Ramya Gamini, Oscar Alvarez-Garcia, Ryuichiro Akagi, Masahiko Saito, Yuta Muramatsu, Takahisa Sasho, James A Koziol, Andrew I Su, Martin K Lotz
OBJECTIVE: Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying therapies are not available, novel therapeutic targets need to be discovered and prioritized for their importance in mediating the abnormal phenotype of cells in OA-affected joints. Here, we generated a genome-wide molecular profile of OA to elucidate regulatory mechanisms of OA pathogenesis and to identify possible therapeutic targets using integrative analysis of mRNA-sequencing data obtained from human knee cartilage...
August 3, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/30066923/screening-of-exosomal-mirnas-derived-from-subcutaneous-and-visceral-adipose-tissues-determination-of-targets-for-the-treatment-of-obesity-and-associated-metabolic-disorders
#4
Zheng Yang, Zhuying Wei, Xia Wu, Huidi Yang
Exosomal micro (mi)RNAs have been suggested to have important roles in abdominal obesity, and to be associated with metabolic alterations via posttranscriptional regulation of target genes. However, exosomal miRNA profiles in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) have rarely been investigated. In the present study, microarray data were obtained from the Gene Expression Omnibus database with the following accession numbers: GSE68885 (exosomal miRNAs in SAT obtained from seven patients with obesity and five lean patients), GSE50574 (exosomal miRNAs in VAT obtained from seven patients with obesity and five lean patients) and GSE29718 [mRNAs in SAT (obtained from seven patients with obesity and eight lean patients) and VAT (obtained from three patients with obesity and two lean patients)]...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29981832/global-gene-expression-analysis-identifies-mef2c-as-a-potential-player-in-wnt16-mediated-transcriptional-regulation
#5
Aimy Sebastian, Nicholas R Hum, Cesar Morfin, Deepa K Murugesh, Gabriela G Loots
Wnt16 is a major Wnt ligand involved in the regulation of postnatal bone homeostasis. Previous studies have shown that Wnt16 promotes bone formation and inhibits bone resorption, suggesting that this molecule could be targeted for therapeutic interventions to treat bone thinning disorders such as osteoporosis. However, the molecular mechanisms by which Wnt16 regulates bone metabolism is not yet fully understood. To better understand the molecular mechanisms by which Wnt16 promotes bone formation and to identify the target genes regulated by Wnt16 in osteoblasts, we treated calvarial osteoblasts purified from C57Bl/6 mice with recombinant Wnt16 and profiled the gene expression changes by RNA-seq at 24 h post-treatment...
July 5, 2018: Gene
https://www.readbyqxmd.com/read/29922448/global-transcriptome-analysis-to-identify-critical-genes-involved-in-the-pathology-of-osteoarthritis
#6
X Zhang, Y Bu, B Zhu, Q Zhao, Z Lv, B Li, J Liu
Objectives: The aim of this study was to identify key pathological genes in osteoarthritis (OA). Methods: We searched and downloaded mRNA expression data from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) of joint synovial tissues from OA and normal individuals. Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analyses were used to assess the function of identified DEGs. The protein-protein interaction (PPI) network and transcriptional factors (TFs) regulatory network were used to further explore the function of identified DEGs...
April 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29859287/molecular-network-pathway-and-functional-analysis-of-time-dependent-gene-changes-related-to-cathepsin-g-exposure-in-neonatal-rat-cardiomyocytes
#7
Sanket Kumar Shukla, Kunal Sikder, Amrita Sarkar, Sankar Addya, Khadija Rafiq
The molecular pathways activated in response to acute cathepsin G (CG) exposure, as well as the mechanisms involved in activation of signaling pathways that culminate in myocyte detachment and apoptosis remain unclear. This study aimed to determine the changes in gene expression patterns associated with time dependent CG exposure to neonatal rat cardiomyocytes (NRCMs). Microarray analysis revealed a total of 451, 572 and 1127 differentially expressed genes after CG exposure at 1, 4 and 8 h respectively. A total of 54 overlapped genes at each time point were mapped by Ingenuity Pathway Analysis (IPA)...
May 30, 2018: Gene
https://www.readbyqxmd.com/read/29787988/microrna-30e-promotes-hepatocyte-proliferation-and-inhibits-apoptosis-in-cecal-ligation-and-puncture-induced-sepsis-through-the-jak-stat-signaling-pathway-by-binding-to-fosl2
#8
Lan Ling, Shan-Hong Zhang, Li-Da Zhi, Hong Li, Qian-Kuan Wen, Gang Li, Wen-Jia Zhang
INTRODUCTION: Hepatocyte proliferation and apoptosis are critical cellular behaviors in rat liver as a result of a liver injury. Herein, we performed this study in order to evaluate the role of miR-30e and its target Fos-Related Antigen-2 (FOSL2) in septic rats through the JAK/STAT signaling pathway. METHODS: Rat models of sepsis were induced by cecal ligation and puncture. Enzyme-linked immunosorbent assay (ELISA) was performed to access serum levels of lipopolysaccharide (LPS), inflammatory factors, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) to confirm the successful establishment of the model...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29768211/long-term-persistence-of-exhausted-cd8-t-cells-in-chronic-infection-is-regulated-by-microrna-155
#9
Erietta Stelekati, Zeyu Chen, Sasikanth Manne, Makoto Kurachi, Mohammed-Alkhatim Ali, Keith Lewy, Zhangying Cai, Kito Nzingha, Laura M McLane, Jennifer L Hope, Adam J Fike, Peter D Katsikis, E John Wherry
Persistent viral infections and tumors drive development of exhausted T (TEX ) cells. In these settings, TEX cells establish an important host-pathogen or host-tumor stalemate. However, TEX cells erode over time, leading to loss of pathogen or cancer containment. We identified microRNA (miR)-155 as a key regulator of sustained TEX cell responses during chronic lymphocytic choriomeningitis virus (LCMV) infection. Genetic deficiency of miR-155 ablated CD8 T cell responses during chronic infection. Conversely, enhanced miR-155 expression promoted expansion and long-term persistence of TEX cells...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29762675/rxr-ligands-modulate-thyroid-hormone-signaling-competence-in-young-xenopus-laevis-tadpoles
#10
Brenda J Mengeling, Michael L Goodson, J David Furlow
Appropriate thyroid hormone (TH) signaling through thyroid hormone receptors (TRs) is essential for vertebrate development. Amphibian metamorphosis is initiated and sustained through the action of TH on TRs, which are conserved across vertebrates. TRs heterodimerize with retinoid X receptors (RXRs) on thyroid hormone response elements (TREs) in the genome; however, in most cell line and adult animal studies, RXR ligands do not affect expression of TR target genes. We used a quantitative, precocious metamorphosis assay to interrogate the effects of the RXR agonist bexarotene (Bex) and the RXR antagonist UVI 3003 (UVI) on T3-induced resorption phenotypes in Xenopus laevis tadpoles 1 week postfertilization...
July 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29679657/eleven-loci-with-new-reproducible-genetic-associations-with-allergic-disease-risk
#11
Manuel A R Ferreira, Judith M Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu, Franz Rüschendorf, David A Hinds, Norbert Hübner, Stephan Weidinger, Patrik K E Magnusson, Eric Jorgenson, Young-Ae Lee, Dorret I Boomsma, Robert Karlsson, Catarina Almqvist, Gerard H Koppelman, Lavinia Paternoster
BACKGROUND: A recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever, and eczema. Many more risk loci shared between these common allergic diseases remain to be discovered, which could point to new therapeutic opportunities. OBJECTIVE: We sought to identify novel risk loci shared between asthma, hay fever, and eczema by applying a gene-based test of association to results from a published GWAS that included data from 360,838 subjects...
April 19, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29330462/mir-143-3p-inhibits-the-proliferation-migration-and-invasion-in-osteosarcoma-by-targeting-fosl2
#12
Xiangran Sun, Guo Dai, Ling Yu, Qingzhu Hu, Jingteng Chen, Weichun Guo
Osteosarcoma (OS) is the most common type of primary malignant bone tumor and mainly occurs in children and adolescent. Because of its early migration and invasion, OS has a poor prognosis. It has been reported that mircoRNAs (miRNAs) play a crucial role in the occurrence and development of multiple tumors. In this study, we identified the aberrant-expression of miR-143-3p in osteosarcoma and examined the role of miR-143-3p in OS development. Further, we searched the miR-143-3p target gene and verified its accuracy by luciferase experiments...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29044125/transcription-factor-ctip1-bcl11a-regulates-epidermal-differentiation-and-lipid-metabolism-during-skin-development
#13
Shan Li, Amy Teegarden, Emily M Bauer, Jaewoo Choi, Nadia Messaddeq, David A Hendrix, Gitali Ganguli-Indra, Mark Leid, Arup K Indra
The epidermal permeability barrier (EPB) prevents organisms from dehydration and infection. The transcriptional regulation of EPB development is poorly understood. We demonstrate here that transcription factor COUP-TF-interacting protein 1 (CTIP1/BCL11A; hereafter CTIP1) is highly expressed in the developing murine epidermis. Germline deletion of Ctip1 (Ctip1-/- ) results in EPB defects accompanied by compromised epidermal differentiation, drastic reduction in profilaggrin processing, reduced lamellar bodies in granular layers and significantly altered lipid composition...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393251/mir-597-inhibits-breast-cancer-cell-proliferation-migration-and-invasion-through-fosl2
#14
Jiangtu He, Jieying Mai, Yan Li, Linyi Chen, Hui Xu, Xiaofei Zhu, Qiuhui Pan
Many reports suggest that the discovery of microRNAs (miRNAs) might provide a novel therapeutical target for many diseases, even of human cancers; however, there are no reports on the role of miR-597 in human cancers. In the present study, by detecting mRNA expression with qRT-PCR, compared with the adjacent normal tissues we found that miR-597 was significantly downregulated in breast cancer tissues. By using the MTT assay, the cell wound-healing assay and the cell invasion assay, we demonstrated that miR-597 mimics were able to suppress breast cancer cell proliferation, migration and invasion...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28050569/the-expression-level-of-mrna-protein-and-dna-methylation-status-of-fosl2-of-uyghur-in-xinjiang-in-type-2-diabetes
#15
Jun Li, Siyuan Li, Ying Hu, Guolei Cao, Siyao Wang, Partab Rai, Xiaoli Wang, Kan Sun
Objective. We investigated the expression levels of both FOSL2 mRNA and protein as well as evaluating DNA methylation in the blood of type 2 diabetes mellitus (T2DM) Uyghur patients from Xinjiang. This study also evaluated whether FOSL2 gene expression had demonstrated any associations with clinical and biochemical indicators of T2DM. Methods. One hundred Uyghur subjects where divided into two groups, T2DM and nonimpaired glucose tolerance (NGT) groups. DNA methylation of FOSL2 was also analyzed by MassARRAY Spectrometry and methylation data of individual units were generated by the EpiTyper v1...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27651452/brd4-localization-to-lineage-specific-enhancers-is-associated-with-a-distinct-transcription-factor-repertoire
#16
Zeynab Najafova, Roberto Tirado-Magallanes, Malayannan Subramaniam, Tareq Hossan, Geske Schmidt, Sankari Nagarajan, Simon J Baumgart, Vivek Kumar Mishra, Upasana Bedi, Eric Hesse, Stefan Knapp, John R Hawse, Steven A Johnsen
Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. In this study we examined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is essential for osteoblast differentiation. Genome-wide analyses demonstrate that BRD4 is recruited to the transcriptional start site of differentiation-induced genes...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27586508/gene-expression-of-immediate-early-genes-of-ap-1-transcription-factor-in-human-peripheral-blood-mononuclear-cells-in-response-to-ionizing-radiation
#17
S Nishad, Anu Ghosh
Ionizing radiation (IR) is considered ubiquitous in nature. The immediate early genes are considered the earliest nuclear targets of IR and are induced in the absence of de novo protein synthesis. Many of these genes encode transcription factors that constitute the first step in signal transduction to couple cytoplasmic effects with long-term cellular response. In this paper, coordinated transcript response of fos and jun family members which constitute activator protein 1 transcription factor was studied in response to IR in human peripheral blood lymphocytes at the G0 stage...
November 2016: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/27471255/ap-1-family-members-act-with-sox9-to-promote-chondrocyte-hypertrophy
#18
Xinjun He, Shinsuke Ohba, Hironori Hojo, Andrew P McMahon
An analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif. Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 family members, Jun and Fosl2 were highly expressed within prehypertrophic and early hypertrophic chondrocytes. Chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) showed a striking overlap in Jun- and Sox9-bound regions throughout the chondrocyte genome, reflecting direct binding of each factor to the same enhancers and a potential for protein-protein interactions within AP-1- and Sox9-containing complexes...
August 15, 2016: Development
https://www.readbyqxmd.com/read/27337945/differences-between-perivascular-adipose-tissue-surrounding-the-heart-and-the-internal-mammary-artery-possible-role-for-the-leptin-inflammation-fibrosis-hypoxia-axis
#19
COMPARATIVE STUDY
Ioannis Drosos, Georgios Chalikias, Maria Pavlaki, Dimitra Kareli, Grigorios Epitropou, Georgios Bougioukas, Dimitrios Mikroulis, Fotios Konstantinou, Alexandra Giatromanolaki, Konstantinos Ritis, Thomas Münzel, Dimitrios Tziakas, Stavros Konstantinides, Katrin Schäfer
AIM: The factors mediating the paracrine effects of perivascular adipose tissue (PVAT) in atherosclerosis are largely unknown. The adipokine leptin has been implicated in the increased cardiovascular risk in obesity and may locally promote neointima formation independently of circulating leptin levels. In patients with established coronary artery disease, we examined the expression of leptin as well as of its possible inducers in 'cardiac' PVAT surrounding the aortic root and coronary arteries (C-PVAT), and compared it to the PVAT surrounding the internal mammary artery (IMA-PVAT), a vessel resistant to atherosclerosis...
November 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27200222/functional-profiling-of-human-mecp2-by-automated-data-comparison-analysis-and-computerized-expression-pathway-modeling
#20
Injoo Kim, Shin Hae Lee, Jinwoo Jeong, Jun Hyung Park, Mi Ae Yoo, Cheol Min Kim
OBJECTIVES: Methyl-CpG binding protein 2 (MeCP2) is a ubiquitous epigenetic factor that represses gene expression by modifying chromatin. Mutations in the MeCP2 gene cause Rett syndrome, a progressive neurodevelopmental disorder. Recent studies also have shown that MeCP2 plays a role in carcinogenesis. Specifically, functional ablation of MeCP2 suppresses cell growth and leads to the proliferation of cancer cells. However, MeCP2's function in adult tissues remains poorly understood. We utilized a weight matrix-based comparison software to identify transcription factor binding site (TFBS) of MeCP2-regulated genes, which were recognized by cDNA microarray analysis...
April 2016: Healthcare Informatics Research
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