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Triblock Copolymers

Shinji Sugihara, Masahiro Sudo, Yasushi Maeda
Biomimetic ABC triblock copolymers of poly[2-(methacryloyloxy)ethyl phosphorylcholine]- b-poly[2-(dimethylamino)ethyl methacrylate]- b-poly(2-hydroxypropyl methacrylate) (PMPC- b-PDMA- b-PHPMA) were synthesized by RAFT aqueous dispersion polymerization of 2-hydroxypropyl methacrylate (HPMA) in the presence of a PMPC- b-PDMA macromolecular chain transfer agent (macro-CTA). This ABC triblock copolymer deploys well-known biocompatible PMPC and PDMA for the coordination of Ag+ ions to form silver nanoparticles in situ on reduction, and PHPMA for assembling (core) in water...
August 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Marzieh Najafi, Neda Kordalivand, Mohammad-Amin Moradi, Joep van den Dikkenberg, Remco Fokkink, Heiner Friedrich, Nico A J M Sommerdijk, Mathew Hembury, Tina Vermonden
In this study, native chemical ligation (NCL) was used as a selective crosslinking method to form core-crosslinked thermosensitive polymeric micelles for drug delivery applications. To this end, two complementary ABA triblock copolymers having polyethylene glycol (PEG) as midblock were synthesized by atom transfer radical polymerization (ATRP). The thermosensitive poly isopropyl acrylamide (PNIPAM) outer blocks of the polymers were co-polymerized with either N-(2-hydroxypropyl)methacrylamide-cysteine (HPMA-Cys), P(NIPAM-co-HPMA-Cys)-PEG-P(NIPAM-co-HPMA-Cys) (PNC), or N-(2-hydroxypropyl)methacrylamide-ethylthioglycolate succinic acid (HPMA-ETSA), P(NIPAM-co-HPMA-ETSA)-PEG-P(NIPAM-co-HPMA-ETSA) (PNE)...
August 13, 2018: Biomacromolecules
Jiabin Luan, Zheng Zhang, Wenjia Shen, Yipei Chen, Xiaowei Yang, Xiaobin Chen, Lin Yu, Jian Sun, Jiandong Ding
Medical-grade silicones as implants have been utilized for decades. However, the post-operative complications, such as capsular formation and contracture have not yet been fully controlled and resolved. The aim of the present study is to elucidate whether the capsular formation can be alleviated by local and sustained delivery of low-dose paclitaxel (PTX) during the critical phase after the insertion of silicone implants. A biocompatible and thermogelling poly(lactic acid- co-glycolic acid)- b-poly(ethylene glycol)- b-poly(lactic acid- co-glycolic acid) (PLGA-PEG-PLGA) triblock copolymer was synthesized by us...
August 13, 2018: ACS Applied Materials & Interfaces
Alessio Caciagli, Mykolas Zupkauskas, Aviad Levin, Tuomas P J Knowles, Clement Mugemana, Nico Bruns, Thomas O'Neill, William J Frith, Erika Eiser
Many industrial soft materials include oil-in-water (O/W) emulsions at the core of their formulations. By using tuneable interface stabilizing agents, such emulsions can self-assemble into complex structures. DNA has been used for decades as a thermoresponsive, highly specific binding agent between hard and, recently, soft colloids. Up until now, emulsion droplets functionalized with DNA had relatively low coating densities and were expensive to scale up. Here a general O/W DNA-coating method using functional non-ionic amphiphilic block copolymers, both diblock and triblock, is presented...
August 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Cristina Casadidio, Maria Eugenia Butini, Andrej Trampuz, Mariagrazia Di Luca, Roberta Censi, Piera Di Martino
A drug delivery system based on fully biodegradable thermosensitive hydrogels enabling controlled antibiotic release may support the management of implant-associated infections. In this work, the lipopeptide antibiotic daptomycin was encapsulated in hydrogel networks consisting of vinyl sulfonated triblock copolymers of PEG-p(HPMAm-lac1,2 ) and thiolated hyaluronic acid. High concentrations of active daptomycin exceeding the minimum biofilm eradicating concentration were sustainably eluted from the biodegradable carrier...
September 2018: European Journal of Pharmaceutics and Biopharmaceutics
Qi Zhong, Lei Mi, Ezzeldin Metwalli, Lorenz Bießmann, Martine Philipp, Anna Miasnikova, Andre Laschewsky, Christine M Papadakis, Robert Cubitt, Matthias Schwartzkopf, Stephan V Roth, Jiping Wang, Peter Müller-Buschbaum
The effect of chain architecture on the swelling and thermal response of thin films obtained from an amphiphilic three-arm star-shaped thermo-responsive block copolymer poly(methoxy diethylene glycol acrylate)-block-polystyrene ((PMDEGA-b-PS)3 ) is investigated by in situ neutron reflectivity (NR) measurements. The PMDEGA and PS blocks are micro-phase separated with randomly distributed PS nanodomains. The (PMDEGA-b-PS)3 films show a transition temperature (TT) at 33 °C in white light interferometry. The swelling capability of the (PMDEGA-b-PS)3 films in a D2 O vapor atmosphere is better than that of films from linear PS-b-PMDEGA-b-PS triblock copolymers, which can be attributed to the hydrophilic end groups and limited size of the PS blocks in (PMDEGA-b-PS)3 ...
August 21, 2018: Soft Matter
Jin Ho Lee, Yu Ra Jeong, Geumbee Lee, Sang Woo Jin, Yong Hui Lee, Soo Yeong Hong, Heun Park, Jung Wook Kim, Sang-Soo Lee, Jeong Sook Ha
Here, we report on a highly conductive, stretchable, and transparent electrode of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) fabricated via modification with triblock copolymer, poly(ethylene glycol)- block-poly(propylene glycol)- block-poly(ethylene glycol) (PEO20 -PPO70 -PEO20 , Pluronic P123), and post-treatment with sulfuric acid. The fabricated electrode exhibits high transparency (89%), high electrical conductivity (∼1700 S/cm), and minimal change in resistance (∼4%) under repetitive stretch-release cycles at 40% tensile strain after stabilization...
August 9, 2018: ACS Applied Materials & Interfaces
T P T Dao, F Fernandes, M Fauquignon, E Ibarboure, M Prieto, J F Le Meins
In this work, the elasticity under stretching as well as the fluidity of Giant Hybrid Unilamellar Vesicles (GHUV) has been studied. The membrane structuration of these GHUVs has already been studied at the micro and nanoscale in a previous study of the team. These GHUVs were obtained by the association of a fluid phospholipid (POPC) and a triblock copolymer, poly(ethyleneoxide)-b-poly(dimethylsiloxane)-b-poly(ethyleneoxide). Although the architecture of triblock copolymers can facilitate vesicle formation, they have been scarcely used to generate GHUVs...
August 8, 2018: Soft Matter
Somayyeh Fallah Iri Sofla, Mojtaba Abbasian, Mortaza Mirzaei
Currently an effective strategy in nanomedicine for cancer therapy is the combination of photothermal therapy with chemotherapy. Because combination cancer therapy improve the therapy efficiency by synergistic effects and overcoming drug resistance as compared to monotherapy possesses. According to these facts, gold nanorods-cored biodegradable micelles were prepared by coating gold nanorods (AuNRs) with synthesized pH-sensitive thiol-ended amphiphilic triblock copolymer (PAA-b-PDMAEMAQ-b-PCL-SH). The synthesized AuNRs@polymer was loaded with methotrexate (MTX) as an anticancer drug through electrostatic interactions to afford AuNRs@polymer-MTX...
July 23, 2018: Journal of Biomaterials Science. Polymer Edition
Niels L Meereboer, Ivan Terzić, Sarah Saidi, Daniel Hermida Merino, Katja Loos
The electroactive properties of poly(vinylidene fluoride) (PVDF) are a direct consequence of its crystalline phases. Although poorly understood, nanostructuring PVDF in confined geometries can drastically change its crystallization behavior. Therefore, we synthesized a variety of PVDF-based triblock copolymers to gain a better understanding of the melt crystallization and explore how crystallization is affected by the morphology and chemical nature of the amorphous block. Differential scanning calorimetry, small-/wide-angle X-ray scattering, and transmission electron microscopy gave us excellent insights into the morphology and the corresponding crystalline phases...
July 17, 2018: ACS Macro Letters
Yohann Corvis, Simona Manta, Caroline Thebault, Olivier Couture, Hélène Dhotel, Jean-Philippe Michel, Johanne Seguin, Michel Bessodes, Philippe Espeau, Chantal Pichon, Cyrille Richard, Nathalie Mignet
Amphiphilic triblock (Atri) copolymers made of perfluorinated alkyl chain linked to hydrocarbon chain and methoxy-poly(ethylene glycol) of three different molecular weights were synthesized. In vitro evaluation demonstrated that these new compounds were noncytotoxic. Characterization and interaction of each triblock copolymer with a branched polyamine myristoyl lipid (2-{3[bis-(3-amino-propyl)-amino]-propylamino}- N-ditetradecyl carbamoyl methyl-acetamide, DMAPAP) were studied by the Langmuir film method and thermal analysis...
August 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Haibo Tan, Yunqi Li, Jeonghun Kim, Toshiaki Takei, Zhongli Wang, Xingtao Xu, Jie Wang, Yoshio Bando, Yong-Mook Kang, Jing Tang, Yusuke Yamauchi
Sub-50 nm iron-nitrogen-doped hollow carbon sphere-encapsulated iron carbide nanoparticles (Fe3 C-Fe,N/C) are synthesized by using a triblock copolymer of poly(styrene- b -2-vinylpyridine- b -ethylene oxide) as a soft template. Their typical features, including a large surface area (879.5 m2 g-1 ), small hollow size (≈16 nm), and nitrogen-doped mesoporous carbon shell, and encapsulated Fe3 C nanoparticles generate a highly active oxygen reduction reaction (ORR) performance. Fe3 C-Fe,N/C hollow spheres exhibit an ORR performance comparable to that of commercially available 20 wt% Pt/C in alkaline electrolyte, with a similar half-wave potential, an electron transfer number close to 4, and lower H2 O2 yield of less than 5%...
July 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Matthew Skinner, Brandon M Johnston, Yalin Liu, Brenton Hammer, Ryan Selhorst, Ioanna Xenidou, Sarah L Perry, Todd Emrick
Novel polymer amphiphiles with chemical structures designed as zwitterionic analogs of Pluronic block copolymers were prepared by controlled free radical polymerization of phosphorylcholine (PC) or choline phosphate (CP) methacrylate monomers from a difunctional poly(propylene oxide) (PPO) macroinitiator. Well-defined, water-dispersible zwitterionic triblock copolymers, or "zwitteronics", were prepared with PC content ranging from 5 to 47 mol percent and composition-independent surfactant characteristics in water, which deviate from the properties of conventional Pluronic amphiphiles...
July 19, 2018: Biomacromolecules
Hélène Lajous, Raphaël Riva, Bénédicte Lelièvre, Clément Tétaud, Sylvie Avril, François Hindré, Frank Boury, Christine Jérôme, Philippe Lecomte, Emmanuel Garcion
Glioblastoma is the most frequent and aggressive primary malignant tumor of the central nervous system with a gloomy prognosis. Platinum derivatives and one among them, cisplatin, exhibited promising results when locally administered into the brain of glioblastoma bearing rats. Nanovectorization of anticancer agents through polymeric nanoparticles may even promote drug accumulation within cells, thus concentrating the drug efficiently at its target. Anchorage of gadolinium complexes on the corona of such smart drug delivery systems could further allow magnetic resonance imaging (MRI) monitoring of the nanoplatform biodistribution in the damaged parenchyma and its therapeutic benefit...
July 19, 2018: Biomaterials Science
Mohamed Mokhtar Mohamed, M Khairy, Ahmed Ibrahem
A simple hydrothermal route assisted by a triblock copolymer was used to synthesize Ag2 O/Ag nanoparticles on a robotic support consists of functionalized MWCNTs and graphene composite (Ag2 O/Ag/CNT-graphene). The composites together with the individual analog of Ag/CNT and Ag/graphene were characterized by means of XRD, TEM-SAED, N2 sorptiometry, Raman, FTIR, UV-Vis, and photoluminescence spectroscopy. These nanomaterials were then tested for the catalytic reduction of 4-nitrophenol (4-NP) to the technologically beneficial 4-aminophenol (4-AP)...
2018: Frontiers in Chemistry
Lingping Kong, Xiaoteng Liu, Jinjia Wei, Steven Wang, Ben Bin Xu, Donghui Long, Fei Chen
Orthorhombic Nb2 O5 (T-Nb2 O5 ) nanocrystallites are successfully fabricated through an evaporation induced self-assembly (EISA) method guided by a commercialised triblock copolymer - Pluronic F127. We demonstrate a morphology transition of T-Nb2 O5 from continuous porous nanofilms to monodisperse nanoparticles by changing the content of Pluronic F127. The electrochemical results show that the optimized monodisperse Nb-2 with a particle size of 20 nm achieves premier Li-ion intercalation kinetics and higher rate capability than mesoporous T-Nb2 O5 nanofilms...
August 7, 2018: Nanoscale
Sophie Houvenagel, Laurence Moine, Guilherme Picheth, Camille Dejean, Annie Brûlet, Alexis Chennevière, Vincent Faugeras, Nicolas Huang, Olivier Couture, Nicolas Tsapis
Imaging the enhanced permeation and retention effect by ultrasound is hindered by the large size of commercial ultrasound contrast agents (UCAs). To obtain nanosized UCAs, triblock copolymers of poly(ethylene glycol)-polylactide-poly(1 H,1 H,2 H,2 H-heptadecafluorodecyl methacrylate) (PEG-PLA-PFMA) with distinct numbers of perfluorinated pendant chains (5, 10, or 20) are synthesized by a combination of ring-opening polymerization and atom transfer radical polymerization. Nanocapsules (NCs) containing perfluorooctyl bromide (PFOB) intended as UCAs are obtained with a 2-fold increase in PFOB encapsulation efficiency in fluorinated NCs as compared with plain PEG-PLA NCs thanks to fluorous interactions...
July 24, 2018: Biomacromolecules
Parisa Nasrollahi, Khosro Khajeh, Elnaz Tamjid, Mohammad Taleb, Masoud Soleimani, Guangjun Nie
Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA-PEG-PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA-PEG-PLGA copolymer did not influence its inherent sol-gel transition behaviour, but increased the sol-gel transition...
July 10, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Ziyi Li, Fei Zhou, Zhiyong Li, Siyu Lin, Lei Chen, Lixin Liu, Yongming Chen
A novel hydrogel (HA-az-F127 hydrogel) formed by reacting hydrazide modified hyaluronic acid (HAAD) and benzaldehyde terminated F127 triblock copolymers (BAF127) was developed in this work. The hydrogel with dynamic covalent chemically and micellar physically double-cross-linked networks exhibited rapid gelation and shear thinning properties. Besides, the hydrogel possessed functions, such as adaptable mechanical strength, self-healability, liquid-absorption, or drainage and tissue adhesion, which are important for wound treatment...
August 1, 2018: ACS Applied Materials & Interfaces
Junyan Tan, Dandan Chong, Yue Zhou, Rong Wang, Xinhua Wan, Jie Zhang
Polyoxometalate (POM) H3 PMo12 O40 was coassembled with stimuli-responsive triblock copolymer poly(ethylene oxide)- block-polystyrene- block-poly(2-(dimethylamino)ethyl methacrylate) (PEO- b-PS- b-PDMAEMA) by electrostatic interactions. Depending on the POM contents, the hybrid complexes can self-assemble into a series of morphologies: micelles, rods, toroids, and vesicles. Unlike traditional morphology transition of amphiphilic block copolymer derived from a broad range of hydrophobic volume fractions, POM-induced morphology transitions just occurred in a narrow range of volume fractions...
July 31, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
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