Lauren von Klinggraeff, Chris D Pfledderer, Sarah Burkart, Kaitlyn Ramey, Michal Smith, Alexander C McLain, Bridget Armstrong, R Glenn Weaver, Anthony Okely, David Lubans, John P A Ioannidis, Russell Jago, Gabrielle Turner-McGrievy, James Thrasher, Xiaoming Li, Michael W Beets
Background Preliminary studies (e.g., pilot/feasibility studies) can result in misleading evidence that an intervention is ready to be evaluated in a large-scale trial when it is not. Risk of Generalizability Biases (RGBs, a set of external validity biases) represent study features that influence estimates of effectiveness, often inflating estimates in preliminary studies which are not replicated in larger-scale trials. While RGBs have been empirically established in interventions targeting obesity, the extent to which RGBs generalize to other health areas is unknown...
February 26, 2024: Research Square