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nano photodynamic therapy

Zhijuan Yang, Qian Chen, Jiawen Chen, Ziliang Dong, Rui Zhang, Jingjing Liu, Zhuang Liu
Despite the promises of applying nano-photosensitizers (nano-PSs) for photodynamic therapy (PDT) against cancer, severe tumor hypoxia and limited tumor penetration of nano-PSs would lead to nonoptimized therapeutic outcomes of PDT. Therefore, herein a biocompatible nano-PS is prepared by using tamoxifen (TAM), an anti-estrogen compound, to induce self-assembly of chlorin e6 (Ce6) modified human serum albumin (HSA). The formed HSA-Ce6/TAM nanocomplexes, which are stable under neutral pH with a diameter of ≈130 nm, would be dissociated into individual HSA-Ce6 and TAM molecules under the acidic tumor microenvironment, owing to the pH responsive transition of TAM from hydrophobic to hydrophilic...
October 11, 2018: Small
Rengarajan Baskaran, Junghan Lee, Su-Geun Yang
Background: Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases. Introduction: In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues...
2018: Biomaterials Research
Łukasz Lamch, Agata Pucek, Julita Kulbacka, Michał Chudy, Elżbieta Jastrzębska, Katarzyna Tokarska, Magdalena Bułka, Zbigniew Brzózka, Kazimiera A Wilk
This up-to-date review summarizes the design and current fabrication strategies that have been employed in the area of mono- and multifunctional colloidal nanoparticles - nanocarriers well suited for photodynamic therapy (PDT) and diagnostic purposes. Rationally engineered photosensitizer (PS)-loaded nanoparticles may be achieved via either noncovalent (i.e., self-aggregation, interfacial deposition, interfacial polymerization, or core-shell entrapment along with physical adsorption) or covalent (chemical immobilization or conjugation) processes...
September 18, 2018: Advances in Colloid and Interface Science
Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu
The common existence of hypoxia in solid tumors has been heavily researched because it renders tumors more resistant to most standard therapeutic methods, such as radiotherapy (RT), chemotherapy, and photodynamic therapy (PDT), and is associated with a more malignant phenotype and poor survival in patients with tumors. The development of hypoxia modulation methods for advanced therapeutic activity is therefore of great interest but remains a considerable challenge. Since the significant development of nanotechnology and nanomedicine, functionalized nanomaterials can be exploited as adjuvant "drugs" for these oxygen-dependent standard therapies or as hypoxia initiators for advanced new therapies to solid tumors...
September 20, 2018: Accounts of Chemical Research
O J Fakayode, C A Kruger, S P Songca, H Abrahamse, O S Oluwafemi
Magnetic field enhanced photodynamic therapy is an effective non-invasive technique for the eradication of cancer diseases. In this report, magnetic field enhancement of the photodynamic therapy (PDT) efficacy of a novel methoxypolyethyleneglycol-thiol-SPIONs-gold-meso-tetrakis(4-hydroxyphenyl)porphyrin conjugate (nano-drug) against MCF-7 breast cancer cells was evaluated. The nano-drug exhibited excellent blue and red emissions under suitable ultraviolet (380 nm) and visible (430 nm) excitations and was well taken up by the cells without any significant dark cytotoxicity after 24 h post-incubation...
November 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Liang Zhang, Dong Wang, Ke Yang, Danli Sheng, Bin Tan, Zhigang Wang, Haitao Ran, Hengjing Yi, Yixin Zhong, Han Lin, Yu Chen
Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low therapeutic efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic efficacy by constructing a near-infrared (NIR)-responsive multifunctional nanoplatform for synergistic cancer phototherapy by a single NIR irradiation, which can concurrently achieve mitochondria-targeting phototherapy, synergistic photothermal therapy (PTT)/photodynamic therapy (PDT), self-sufficient oxygen-augmented PDT, and multiple-imaging guidance/monitoring...
August 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Mimi Li, Xia Li, Zhonglian Cao, Yuntong Wu, Ji-An Chen, Jie Gao, Zhijun Wang, Wei Guo, Xianfeng Gu
In this paper, a series of novel BODIPY-based photosensitizers have been designed and synthesized for photodynamic therapy. BODIPY3 was screened out as the most potential photosensitizer due to its excellent optical properties, high singlet oxygen efficiency and good photostability. However, as an organic photosensitizer, BODIPY3 still suffered from the drawbacks of insolubility and instability in aqueous system. In view of these problems, DSPE-PEG2000 was used to trap BODIPY3 into the hydrophobic core of micelles to obtain well-dispersing nano complexes BODIPY3-PEG3 in aqueous system...
September 5, 2018: European Journal of Medicinal Chemistry
Zhan Zhou, Yuhui Zheng, Cheng Cheng Zhang, Jinwei Gao, Yiping Tang, Qianming Wang
Carbonaceous materials have long been developed to utilize "nano-spaces" and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed...
October 10, 2018: Photochemical & Photobiological Sciences
Channay Naidoo, Cherie Ann Kruger, Heidi Abrahamse
This review article is based on specifically targeted nanoparticles that have been used in the treatment of melanoma. According to the Skin Cancer Foundation, within 2017 an estimated 9730 people will die due to invasive melanoma. Conventional treatments for nonmalignant melanoma include surgery, chemotherapy, and radiation. For the treatment of metastatic melanoma, 3 therapeutic agents have been approved by the Food and Drug Administration: dacarbazine, recombinant interferon α-2b, and high-dose interleukin 2...
January 1, 2018: Technology in Cancer Research & Treatment
Hairong Wang, Yu Chao, Jingjing Liu, Wenwen Zhu, Guanglin Wang, Ligeng Xu, Zhuang Liu
Tumor hypoxia is known to be one of critical factors that aggravate the tumor resistance to photodynamic therapy (PDT) in which oxygen is essential for tumor destruction. Herein, catalase, an enzyme to trigger hydrogen peroxide (H2 O2 ) decomposition, is modified by in-situ free radical polymerization, using meso-tetra(p-hydroxyphenyl) porphine (THPP) as the cross-linker to enable condensed grafting of short polyethylene glycol (PEG) chains on the protein surface as a permeable brush-like safeguard. The formulated catalase-entrapped nanocapsules (CAT-THPP-PEG) with enhanced enzyme stability can be labeled with 99m Tc4+ , a radioisotope ion that is chelated by the porphyrin structure of THPP, to allow in vivo single-photon emission computed tomography (SPECT) imaging...
October 2018: Biomaterials
Ali Saafan, Mohamed H Zaazou, Marwa K Sallam, Osama Mosallam, Heba A El Danaf
AIM: To assess the antibacterial competence of 650 nm diode laser, Methylene Blue (MB) and Silver Nano-Particles (Ag NPs) on Streptococcus mutans in biofilm-induced caries models. MATERIAL AND METHODS: One hundred eighty specimens were prepared and equally divided into 6 groups. One group was untreated (control), and the others were subjected to either MB, laser, Ag NPs, the combination of MB and Laser or MB, laser and Ag NPs. RESULTS: Comparison of the log10 mean Colony Forming Units per millilitre (CFU/ml) values of each of the treated 5 groups and the control group was found statistically significant (P-value < 0...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Azadeh Golmohamadpour, Bahram Bahramian, Mehdi Khoobi, Maryam Pourhajibagher, Hamid Reza Barikani, Abbas Bahador
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) has been emerged as one of the promising non-invasive adjuvant for the treatment of endodontic infections. The key part of this technique is application of an optimized nontoxic photosensitizer (PS), like indocyanine green (ICG) activated by light source destroying bacterial contaminants. Notwithstanding all featured properties of ICG, this PS mainly suffers from the lack of stability and concentration-dependent aggregation. A variety of nanomaterials (NMs) has been widely exploited to improve the stability and efficiency of ICG...
August 2, 2018: Photodiagnosis and Photodynamic Therapy
Jieling Li, Anhe Wang, Luyang Zhao, Qianqian Dong, Meiyue Wang, Haolan Xu, Xuehai Yan, Shuo Bai
Employing nanoscaled materials as photosensitizer (PS) carriers is an effective strategy to solve the problem of poor solubility and low tumor selectivity of hydrophobic PS in photodynamic therapy (PDT), which compulsorily requires the PS release in PDT implementation. However, the complicated environment in vivo makes it difficult to precisely design and control the release process and the delivery process requires real-time tracking. Developing a delivery strategy of hydrophobic PS in the monomeric form with fluorescent emission and without consideration of the PS release in the PDT process, is in urgent demand...
August 29, 2018: ACS Applied Materials & Interfaces
Rui Gao, Xuan Mei, Dongpeng Yan, Ruizheng Liang, Min Wei
Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibility. Here, we develop near-infrared laser activated supramolecular photosensitizers (isophthalic acid/layered double hydroxide nanohybrids) for efficient two-photon photodynamic therapy. The singlet oxygen quantum yield of nanohybrid is up to 0...
July 18, 2018: Nature Communications
Farzaneh Ghorbani, Armin Imanparast, Fatemeh Hataminia, Ameneh Sazgarnia
BACKGROUND: In this study, iron oxide nanoparticles (SPIONs) were synthesized and coated by GA (SG) and then SG was encapsulated by ICG (SGI). After identifying specifications and cytotoxicity of the agents, the potential of SGI for photodynamic therapy (PDT) and photothermal therapy (PTT) was studied. METHODS: An SGI size of 12-13 nm was determined by TEM images and its zeta potential was measured at -23.8 ± 5.8 mV. MCF-7 and HT-29 cells were exposed to a non-coherent light source at a wavelength of 730 nm and a range of 3...
July 14, 2018: Photodiagnosis and Photodynamic Therapy
Hongqian Cao, Yanfei Qi, Yang Yang, Lei Wang, Jiaheng Sun, Yue Li, Jiarui Xia, Hao Wang, Junbai Li
In recent years, one of main obstacles in a photodynamic therapy (PDT) process has been that most photosensitizers for PDT are excited by visible light with limited penetrating ability; thus most applications of PDT are for superficial treatments. One of the methods to increase the treatment depth is to introduce a two-photon-active technique into PDT, known as TP-PDT. The difficulty here is to obtain photosensitizers with a large enough two-photon absorption cross-section. In this work, an organic nanocomplex, composed of the two-photon nanoaggregate as the core and photosensitizer as the shell, has been constructed...
July 15, 2018: Chemistry, An Asian Journal
Xianhe Sun, Abudureheman Zebibula, Xiaobiao Dong, Guanxin Zhang, Deqing Zhang, Jun Qian, Sailing He
Aggregation-induced emission (AIE) nanoparticles have been shown promise for fluorescence bioimaging and photodynamic therapy due to the good combination of nanoparticles and organic dyes or photosensitizers. Among several kinds of AIE nanoparticles, those that are capsulated with nanographene oxides (NGO) are easy to make, size-tunable, and have proven to be very stable in deionized water. However, the stability in saline solution still needs improvement for further applications in chemical or biomedical fields, and the efficacy of photodynamic therapy using NGO-capsulate AIE photosensitizers has not been evaluated yet...
August 1, 2018: ACS Applied Materials & Interfaces
Samir Ali Abd El-Kaream, Gihan Hosny Abd Elsamie, Azhar Salim Abd-Alkareem
The underlying work was conducted aiming at cancer targeted therapy using the sono-photodynamic therapy (SPDT) in combination with sonnelux (SLux) as a sono-photosensitizer loaded on folic acid conjugated nanographene oxide nanoparticles (FA-NGO-SLux) as an up-to-date treating cancer modality. Study was conducted on A total of 130 male Swiss albino mice with age 60-65 day, weighing 20 ± 25 g, inoculated with Ehrlich ascites carcinoma (EAC) subdivided into 13 group. Two sources of energy were used; namely infrared laser and Ultrasound (pulsed and continuous wave mode)...
September 5, 2018: Biochemical and Biophysical Research Communications
Yuxiang Zhang, Ping Huang, Dong Wang, Jincan Chen, Wenzhen Liu, Ping Hu, Mingdong Huang, Xueyuan Chen, Zhuo Chen
An alarming worldwide increase in microbial resistance to traditional drugs and classical pharmacophores has spurred the search for new antimicrobial compounds. Antimicrobial photodynamic therapy (aPDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms. However, some of the factors, including the aggregation of the hydrophobic photosensitizer (PS) in aqueous media and the inefficient biodistribution of PS limit its expansion to clinical conditions...
August 23, 2018: Nanoscale
Doaa A Abdel Fadeel, Ghada Muneer, Asma M Elsharif, Suhailah S Al-Jameel, Hanan H Mohamed, Tamer E Youssef
BACKGROUND: The aim of the present study was to modify the structural activity of zinc(II)phthalocyanine by combining it with thiophenyl groups then loaded in lipid nano-carriers and evaluates its parameters required for the structure-activity relationship (SAR) for photodynamic therapy (PDT) of cancer. METHODS: Tetra (4-Thiophenyl) sulphonated phthalocyaninatozinc(II) (PhS.SO3 Na)4 ZnPc 5 was synthesized and characterized by various spectroscopic methods as a test compound...
June 2, 2018: Photodiagnosis and Photodynamic Therapy
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