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nano photodynamic therapy

Hairong Wang, Yu Chao, Jingjing Liu, Wenwen Zhu, Guanglin Wang, Ligeng Xu, Zhuang Liu
Tumor hypoxia is known to be one of critical factors that aggravate the tumor resistance to photodynamic therapy (PDT) in which oxygen is essential for tumor destruction. Herein, catalase, an enzyme to trigger hydrogen peroxide (H2 O2 ) decomposition, is modified by in-situ free radical polymerization, using meso-tetra(p-hydroxyphenyl) porphine (THPP) as the cross-linker to enable condensed grafting of short polyethylene glycol (PEG) chains on the protein surface as a permeable brush-like safeguard. The formulated catalase-entrapped nanocapsules (CAT-THPP-PEG) with enhanced enzyme stability can be labeled with 99m Tc4+ , a radioisotope ion that is chelated by the porphyrin structure of THPP, to allow in vivo single-photon emission computed tomography (SPECT) imaging...
August 4, 2018: Biomaterials
Ali Saafan, Mohamed H Zaazou, Marwa K Sallam, Osama Mosallam, Heba A El Danaf
AIM: To assess the antibacterial competence of 650 nm diode laser, Methylene Blue (MB) and Silver Nano-Particles (Ag NPs) on Streptococcus mutans in biofilm-induced caries models. MATERIAL AND METHODS: One hundred eighty specimens were prepared and equally divided into 6 groups. One group was untreated (control), and the others were subjected to either MB, laser, Ag NPs, the combination of MB and Laser or MB, laser and Ag NPs. RESULTS: Comparison of the log10 mean Colony Forming Units per millilitre (CFU/ml) values of each of the treated 5 groups and the control group was found statistically significant (P-value < 0...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
Azadeh Golmohamadpour, Bahram Bahramian, Mehdi Khoobi, Maryam Pourhajibagher, Hamid Reza Barikani, Abbas Bahador
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) has been emerged as one of the promising non-invasive adjuvant for the treatment of endodontic infections. The key part of this technique is application of an optimized nontoxic photosensitizer (PS), like indocyanine green (ICG) activated by light source destroying bacterial contaminants. Notwithstanding all featured properties of ICG, this PS mainly suffers from the lack of stability and concentration-dependent aggregation. A variety of nanomaterials (NMs) has been widely exploited to improve the stability and efficiency of ICG...
August 2, 2018: Photodiagnosis and Photodynamic Therapy
Jieling Li, Anhe Wang, Luyang Zhao, Qianqian Dong, Meiyue Wang, Haolan Xu, Xuehai Yan, Shuo Bai
Employing nano-scaled materials as photosensitizer (PS) carriers is an effective strategy to solve the problem of poor solubility and low tumor selectivity of hydrophobic PS in photodynamic therapy (PDT), which compulsorily requires the PS release in PDT implementation. However, the complicated environment in vivo makes it difficult to precisely design and control the release process and the delivery process requires real-time tracking. Developing a delivery strategy of hydrophobic PS in the monomeric form with fluorescent emission and without consideration of the PS release in the PDT process, is in urgent demand...
August 1, 2018: ACS Applied Materials & Interfaces
Rui Gao, Xuan Mei, Dongpeng Yan, Ruizheng Liang, Min Wei
Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibility. Here, we develop near-infrared laser activated supramolecular photosensitizers (isophthalic acid/layered double hydroxide nanohybrids) for efficient two-photon photodynamic therapy. The singlet oxygen quantum yield of nanohybrid is up to 0...
July 18, 2018: Nature Communications
Farzaneh Ghorbani, Armin Imanparast, Fatemeh Hataminia, Ameneh Sazgarnia
BACKGROUND: In this study, iron oxide nanoparticles (SPIONs) were synthesized and coated by GA (SG) and then SG was encapsulated by ICG (SGI). After identifying specifications and cytotoxicity of the agents, the potential of SGI for photodynamic therapy (PDT) and photothermal therapy (PTT) was studied. METHODS: An SGI size of 12-13 nm was determined by TEM images and its zeta potential was measured at -23.8 ± 5.8 mV. MCF-7 and HT-29 cells were exposed to a non-coherent light source at a wavelength of 730 nm and a range of 3...
July 14, 2018: Photodiagnosis and Photodynamic Therapy
Hongqian Cao, Yanfei Qi, Yang Yang, Lei Wang, Jiaheng Sun, Yue Li, Jiarui Xia, Hao Wang, Junbai Li
In recent years, one of main obstacles in a photodynamic therapy (PDT) process is that most of photosensitizers for PDT are excited by visible light with limited penetrating ability, resulting that most of applications of PDT are for superficial treatments. One of methods to increase the treatment depth is introducing a two-photon active technique into PDT, as TP-PDT. The difficulty here is how to obtain photosensitizers with enough large two-photon absorption cross-section. In this work, we constructed an organic nanocomplex which was composed with two-photon nano-aggregate as the core and photosensitizer as the shell...
July 15, 2018: Chemistry, An Asian Journal
Xianhe Sun, Abudureheman Zebibula, Xiaobiao Dong, Guanxin Zhang, Deqing Zhang, Jun Qian, Sailing He
Aggregation-induced emission (AIE) nanoparticles have been shown promise for fluorescence bioimaging and photodynamic therapy due to the good combination of nanoparticles and organic dyes or photosensitizers. Among several kinds of AIE nanoparticles, those that are capsulated with nanographene oxides (NGO) are easy to make, size-tunable, and have proven to be very stable in deionized water. However, the stability in saline solution still needs improvement for further applications in chemical or biomedical fields, and the efficacy of photodynamic therapy using NGO-capsulate AIE photosensitizers has not been evaluated yet...
August 1, 2018: ACS Applied Materials & Interfaces
Samir Ali Abd El-Kaream, Gihan Hosny Abd Elsamie, Azhar Salim Abd-Alkareem
The underlying work was conducted aiming at cancer targeted therapy using the sono-photodynamic therapy (SPDT) in combination with sonnelux (SLux) as a sono-photosensitizer loaded on folic acid conjugated nanographene oxide nanoparticles (FA-NGO-SLux) as an up-to-date treating cancer modality. Study was conducted on A total of 130 male Swiss albino mice with age 60-65 day, weighing 20 ± 25 g, inoculated with Ehrlich ascites carcinoma (EAC) subdivided into 13 group. Two sources of energy were used; namely infrared laser and Ultrasound (pulsed and continuous wave mode)...
July 3, 2018: Biochemical and Biophysical Research Communications
Yuxiang Zhang, Ping Huang, Dong Wang, Jincan Chen, Wenzhen Liu, Ping Hu, Mingdong Huang, Xueyuan Chen, Zhuo Chen
An alarming worldwide increase in microbial resistance to traditional drugs and classical pharmacophores has spurred the search for new antimicrobial compounds. Antimicrobial photodynamic therapy (aPDT) has recently emerged as an effective modality for the selective destruction of bacteria and other pathogenic microorganisms. However, some of the factors, including the aggregation of the hydrophobic photosensitizer (PS) in aqueous media and the inefficient biodistribution of PS limit its expansion to clinical conditions...
June 8, 2018: Nanoscale
Doaa A Abdel Fadeel, Ghada Muneer, Asma M Elsharif, Suhailah S Al-Jameel, Hanan H Mohamed, Tamer E Youssef
BACKGROUND: The aim of the present study was to modify the structural activity of zinc(II)phthalocyanine by combining it with thiophenyl groups then loaded in lipid nano-carriers and evaluates its parameters required for the structure-activity relationship (SAR) for photodynamic therapy (PDT) of cancer. METHODS: Tetra (4-Thiophenyl) sulphonated phthalocyaninatozinc(II) (PhS.SO3 Na)4 ZnPc 5 was synthesized and characterized by various spectroscopic methods as a test compound...
June 2, 2018: Photodiagnosis and Photodynamic Therapy
Hoay Yan Cheah, Elena Gallon, Fabienne Dumoulin, See Ziau Hoe, Nina Japundžić-Žigon, Sofija Glumac, Hong Boon Lee, Prem Anand, Lip Yong Chung, Maria Jesus Vicent, Lik Voon Kiew
We previously developed a new zinc(II) phthalocyanine (ZnPc) derivative (Pc 1) conjugated to poly-L-glutamic acid (PGA) (1-PG) to address the limitations of ZnPc as part of an antitumor photodynamic therapy approach, which include hydrophobicity, phototoxicity, and nonselectivity in biodistribution and tumor targeting. During this study, we discovered that 1-PG possessed high near-infrared (NIR) light absorptivity (λmax = 675 nm), good singlet oxygen generation efficiency in an aqueous environment, and enhanced photocytotoxic efficacy and cancer cell uptake in vitro...
July 2, 2018: Molecular Pharmaceutics
Zongfang Wang, Min Hu, Shugang Hu, Jia Han, Zhenzhen Wang, Yanke Chen, Cheng Huang, Lei Fu, Zhenxi Zhang
By integrating imaging and drug-delivery in a single system, fluorescent nano-multifunctional imaging platforms can offer simultaneous diagnosis and therapy to diseases like cancer. However, the synthesis of such system involves a tedious, time-consuming, and multi-step process. Herein we report a facile method based on simple ultrasonication to synthesize highly cross-linked, monodispersed fluorescent polyphosphazene nanoparticles from hexachlorocyclotriphosphazene (HCCP) and dichlorofluorescein (FD). Various functional groups (folic acid, PEG-NH2 , and methylene blue) can be "fastened" in situ onto the poly(cyclotriphosphazene-co-dichlorofluorescein) (PCTPDF) nanoparticles to expand its application as nano-multifunctional platform...
May 3, 2018: Analytical and Bioanalytical Chemistry
Andrej Hovan, Shubhashis Datta, Sergei G Kruglik, Daniel Jancura, Pavol Miskovsky, Gregor Bánó
The singlet oxygen produced by energy transfer between an excited photosensitizer (pts) and ground-state oxygen molecules plays a key role in photodynamic therapy. Different nanocarrier systems are extensively studied to promote targeted pts delivery in a host body. The phosphorescence kinetics of the singlet oxygen produced by the short laser pulse photosensitization of pts inside nanoparticles is influenced by singlet oxygen diffusion from the particles to the surrounding medium. Two theoretical models are presented in this work: a more complex numerical one and a simple analytical one...
May 24, 2018: Journal of Physical Chemistry. B
Hongqian Cao, Lei Wang, Yang Yang, Juan Li, Yanfei Qi, Yue Li, Ying Li, Hao Wang, Junbai Li
Photodynamic therapy (PDT) shows unique selectivity and irreversible destruction toward treated tissues or cells, but still has several problems in clinical practice. One is limited therapeutic efficiency, which is attributed to hypoxia in tumor sites. Another is the limited treatment depth because traditional photosensitizes are excited by short wavelength light (<700 nm). An assembled nano-complex system composed of oxygen donor, two-photon absorption (TPA) species, and photosensitizer (PS) was synthesized to address both problems...
April 27, 2018: Angewandte Chemie
Dandan Xu, Yongqiang You, Fanyu Zeng, Yong Wang, Chunyan Liang, Huanhuan Feng, Xing Ma
Photodynamic therapy (PDT), an alternative to conventional cancer therapeutics, has gained increasing attention for its noninvasive advantage and simultaneous fluorescence imaging property. PDT is a tripartite process that functions in the simultaneous presence of a photosensitizer (PS), light, and available oxygen molecules. However, many highly efficient PSs are hydrophobic and highly tend to self-aggregate in aqueous solution, leading to quick quenching of the PDT effect. Here we construct zeolitic imidazolate framework-8 (ZIF-8) containing water-insoluble photosensitizer zinc(II) phthalocyanine (ZnPc), a typical hydrophobic PS, by one-step coprecipitation process, named as ZnPc@ZIF-8...
May 9, 2018: ACS Applied Materials & Interfaces
Jie Li, Shu Yao, Kai Wang, Zaijun Lu, Xuantao Su, Li Li, Cunzhong Yuan, Jinbo Feng, Shi Yan, Beihua Kong, Kun Song
Photodynamic therapy (PDT) is considered an innovative and attractive modality to treat ovarian cancer. In the present study, a biodegradable polymer poly (ethylene glycol) (PEG)-poly (lactic acid)(PLA)-folate (FA-PEG-PLA) was prepared in order to synthesize an active-targeting, water-soluble and pharmacomodulated photosensitizer nanocarrier. Drug-loading content, encapsulation efficiency, in vitro and in vivo release were characterized, in which hypocrellin B (HB)/FA-PEG-PLA micelles had a high encapsulation efficiency and much slower control release for drugs compared to free drugs (P < ...
June 2018: Cancer Science
Ruiwei Guo, Guang Yang, Zujian Feng, Yujie Zhu, Pengxiang Yang, Huijuan Song, Weiwei Wang, Pingsheng Huang, Jianhua Zhang
In recent years, photodynamic therapy (PDT) was considered to be a promising cancer treatment modality, however, the therapeutic efficiency was often attenuated by the intrinsic antioxidant defense systems. Herein, a kind of novel glutathione-induced amino-activatable micelle was designed, which was expected to weaken the antioxidant capacity and in the meantime release the photosensitizer by the exhaustion of intracellular glutathione (GSH). The amphiphilic poly(ethylene glycol)-(2-((2,4-dinitro-N-(ethyl) phenyl)sulfonamido) ethyl methacrylate) copolymers were synthesized and assembled into a core-shell nano structure in aqueous media...
May 1, 2018: Biomaterials Science
Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li, Zhuang Liu
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment. For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that are most vulnerable to reactive oxygen species (ROS). Second, as oxygen is critical for PDT-induced cancer destruction, overcoming hypoxia existing in the majority of solid tumors is important for optimizing PDT efficacy...
April 11, 2018: Nano Letters
Xiaoyan Yang, Gongyuan Liu, Yunhao Shi, Wei Huang, Jinjun Shao, Xiaochen Dong
Black phosphorus (BP), emerging as a new member of two-dimensional nanomaterials, has attracted growing research interests for its amazing photoelectric properties and promising application in electronic devices. Recently, BP has been confirmed to be a desirable candidate for phototherapy against cancer, including photothermal therapy and photodynamic therapy. By regulating the number of layers, the bandgap of BP nanosheets (NSs) can be finely tuned to present near infrared light triggered phototherapeutic behaviors...
June 1, 2018: Nanotechnology
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