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Calcium oxide

Qiwen Liao, Shengnan Li, Shirley Weng In Siu, Jean-Étienne R L Morlighem, Clarence Tsun Ting Wong, Xiufen Wang, Gandhi Rádis-Baptista, Simon Ming-Yuen Lee
We previously reported a novel toxic peptide identified from the anthozoan Protopalythoa variabilis transcriptome which is homologous to a novel structural type of sodium channel toxin isolated from a parental species (Palythoa caribaeorum). The peptide was named, according to its homologous, as Pp V-shape α-helical peptide (PpVα) in the present study. Through molecular docking and dynamics simulation, linear and hairpin folded PpVα peptides were shown to be potential voltage-gated sodium channel blockers...
October 17, 2018: Archives of Toxicology
Rosella Abeti, Alexander F Brown, Marta Maiolino, Sandip Patel, Paola Giunti
Friedreich's Ataxia (FRDA) is a neurodegenerative disorder, characterized by degeneration of dorsal root ganglia, cerebellum and cardiomyopathy. Heart failure is one of the most common causes of death for FRDA patients. Deficiency of frataxin, a small mitochondrial protein, is responsible for all clinical and morphological manifestations of FRDA. The focus of our study was to investigate the unexplored Ca2+ homeostasis in cerebellar granule neurons (CGNs) and in cardiomyocytes of FRDA cellular models to understand the pathogenesis of degeneration...
2018: Frontiers in Cellular Neuroscience
Kavina Ganapathy, Indrani Datta, Ramesh Bhonde
Dental pulp stem cells (DPSCs) are promising for use in neurodegenerative-diseases because of their neural crest origin. While neuronal differentiation of DPSCs has been shown, their plasticity towards astrocyte-like cells remains to be studied. We aimed to examine differentiation potential of DPSCs to astrocytes and their consequent neuroprotective role towards dopaminergic (DA) neurons under 6-hydroxydopamine (6-OHDA) toxicity. Induction of DPSCs to astrocytes with differentiation factors showed definitive increase in astrocyte-specific markers glial fibrillary acidic protein (GFAP), and excitatory amino acid transporter 2 along with glial calcium-binding protein S100β through FACS and immunofluorescence assays...
October 16, 2018: Molecular Neurobiology
Seo-Young Kim, Yu-Kyoung Kim, Kyung-Seon Kim, Kwang-Bok Lee, Min-Ho Lee
To control the bio-absorption rate of Mg alloy and improve its biocompatibility, a BMP-2 of various concentrations (20, 50, and 100 ng/mL) was immobilized in the carrier layer formed by micro-arc oxidation + hydrothermal treatment on the surface of Mg alloy. Their morphological and chemical properties were evaluated by FE-SEM with EDS and XRD. The electrochemical corrosion behavior was examined, and the cytotoxicity was assessed by WST and ALP assay. After in vivo test during 2 and 4 weeks in the rat tibia, histological observation was performed...
September 27, 2018: Colloids and Surfaces. B, Biointerfaces
Evan N Keyzer, Peter D Matthews, Zigeng Liu, Andrew D Bond, Clare P Grey, Dominic S Wright
Correction for 'Synthesis of Ca(PF6)2, formed via nitrosonium oxidation of calcium' by Evan N. Keyzer et al., Chem. Commun., 2017, 53, 4573-4576.
October 16, 2018: Chemical Communications: Chem Comm
Emőke Sikora, Ádám Prekob, Gyula Halasi, László Vanyorek, Péter Pekker, Ferenc Kristály, Tamás Varga, János Kiss, Zoltán Kónya, Béla Viskolcz
Nitrogen-doped, bamboo-like carbon nanotubes (BCNTs) were synthesized from butylamine by catalytic chemical vapor deposition (CCVD method). The nanotubes were oxidized by H2 SO4 /HNO3 treatment and used to prepare calcium alginate gelled BCNT spheres. These beads were first carbonized and then Pd, Rh and Ni nanoparticles were anchored on the surface of the spheres. These systems were then applied as catalysts in CO2 hydrogenation. The BCNT support was examined by Raman spectroscopy, dynamic light scattering (DLS) and X-ray photoelectron spectroscopy (XPS)...
October 2018: ChemistryOpen
Yebin Zhou, Ling-Ling An, Raghothama Chaerkady, Nanette Mittereder, Lori Clarke, Taylor S Cohen, Bo Chen, Sonja Hess, Gary P Sims, Tomas Mustelin
Neutrophils are critical for the defense against pathogens, in part through the extrusion of extracellular DNA traps, phagocytosis, and the production of reactive oxygen species. Neutrophils may also play an important role in the pathogenesis of rheumatoid arthritis (RA) through the activation of protein arginine deiminases (PADs) that citrullinate proteins that subsequently act as autoantigens. We report that PAD4 is physically associated with the cytosolic subunits of the oxidative burst machinery, p47phox (also known as neutrophil cytosol factor 1, NCF1) and p67phox (NCF2)...
October 15, 2018: Scientific Reports
Méry Marimoutou, Danielle A Springer, Chengyu Liu, Geumsoo Kim, Rodney L Levine
Methionine 77 in calmodulin can be stereospecifically oxidized to methionine sulfoxide by mammalian methionine sulfoxide reductase A. Whether this has in vivo significance is unknown. We therefore created a mutant mouse in which wild type calmodulin-1 was replaced by a calmodulin containing a mimic of methionine sulfoxide at residue 77. Total calmodulin levels were unchanged in the homozygous M77Q mutant, which is viable and fertile. No differences were observed on learning tests, including the Morris water maze and associative learning...
October 13, 2018: Antioxidants (Basel, Switzerland)
Tania Domínguez-Fernández, Mario Alberto Rodríguez, Virginia Sánchez Monroy, Consuelo Gómez García, Olivia Medel, David Guillermo Pérez Ishiwara
Oxygen or nitrogen oxidative species and chemical stress induce the programmed cell death (PCD) of Entamoeba histolytica trophozoites. PCD caused by the aminoglycoside G418 is reduced by incubation with the cysteine protease inhibitor E-64; however, no typical caspases or metacaspases have been detected in this parasite. Calpain, a cysteine protease activated by calcium, has been suggested to be part of a specific PCD pathway in this parasite because the specific calpain inhibitor Z-Leu-Leu-Leu-al diminishes the PCD of trophozoites...
2018: Frontiers in Cellular and Infection Microbiology
Nathanael Matei, Richard Camara, John H Zhang
Clinical and pre-clinical studies have reported a broad range of applications for hydrogen gas therapy. Classically, conventional antioxidant therapy is limited because it neutralizes both the detrimental and protective effects of reactive oxygen species. As a weak reducing agent, hydrogen gas avoids this paradox by reacting with strong oxidants while leaving other beneficial oxidants reactive. This review gathers a promising list of hydrogen gas applications that merit further mechanistic investigation and additional therapeutic trials...
July 2018: Medical Gas Research
Ebrahim Fayyazi, Barat Ghobadian, Henk H van de Bovenkamp, Gholamhassan Najafi, Bahram Hosseinzadehsamani, Hero Jan Heeres, Jun Yue
Solid calcium oxide (CaO) catalyst was prepared via the calcination of chicken eggshells as an environmentally friendly waste resource and incorporated in a continuous centrifugal contactor separator (CCCS) for intensified biodiesel synthesis. Biodiesel or fatty acid methyl esters (FAME) were produced via the transesterification of sunflower oil (containing 5 wt % tetrahydrofuran as a cosolvent) with methanol under 60 °C and separated from the glycerol and catalyst phases continuously in the CCCS. The influence of reaction parameters on biodiesel production was well modeled by response surface methodology...
September 26, 2018: Industrial & Engineering Chemistry Research
Leonardo Santana Novaes, Nilton Barreto Dos Santos, Guilherme Dragunas, Juliano Genaro Perfetto, Juan Carlos Leza, Cristoforo Scavone, Carolina Demarchi Munhoz
Chronic psychogenic stress can increase neuronal calcium influx and generate the intracellular accumulation of oxidative (ROS) and nitrosative (RNS) reactive species, disrupting synaptic transmission in the brain. These molecules impair the Na,K-ATPase (NKA) activity, whose malfunction has been related to neuropsychiatric disorders, including anxiety, depression, schizophrenia, and neurodegenerative diseases. In this study, we assessed how 14 days of restraint stress in rats affect NKA activity via oxidative/nitrosative damage in the frontal cortex (FCx), a crucial region for emotional and cognitive control...
October 11, 2018: Neuroscience
Elis Aguiar Morra, Paula Lopes Rodrigues, Itamar Couto Guedes de Jesus, Patrícia Ribeiro Do Val Lima, Renata Andrade Ávila, Tadeu Ériton Caliman Zanardo, Breno Valentim Nogueira, Donald M Bers, Silvia Guatimosim, Ivanita Stefanon, Rogério Faustino Ribeiro Júnior
We previously demonstrated that the loss of female hormones induces cardiac and mitochondrial dysfunction in the female heart. Here, we show the impact of endurance training for twelve weeks, a nonpharmacological therapy against cardiovascular disease caused by ovariectomy and its contribution to cardiac contractility, mitochondrial quality control, bioenergetics and oxidative damage. We found that ovariectomy induced cardiac hypertrophy and dysfunction by decreasing SERCA2 and increasing phospholamban protein expression...
October 10, 2018: Free Radical Biology & Medicine
Bahar Gürlek Demirci, Emre Tutal, Irem O Eminsoy, Eyup Kulah, Siren Sezer
OBJECTIVE: We aimed to analyze the relationship between the effect of total dietary fiber intake on C-reactive protein (CRP) and on oxidative stress parameters such as serum advanced glycation end products (AGEs), superoxide dysmutase (SOD), malondialdehyde, and arterial stiffness by pulse wave velocity (PWv) in maintanace hemodialysis (MHD) patients. METHODS: Among 650 MHD patients, 128 were selected according to inclusion criteria. The dietary survey was performed with a 3-day dietary history...
October 9, 2018: Journal of Renal Nutrition
Chun-Yu Chen, Yung-Fong Tsai, Wei-Ju Huang, Chang Shih-Hsin, Tsong-Long Hwang
Critically ill patients have a high risk of sepsis. Various studies have demonstrated that propofol has anti-inflammatory effects that may benefit critically ill patients who require anesthesia. However, the mechanism and therapeutic effect remain incompletely understood. Our previous data suggest that propofol can act as a formyl peptide receptor 1 (FPR1) antagonist. Here, we hypothesize that propofol mitigates sepsis-induced acute lung injury (ALI) by inhibiting mitochondria-derived N-formyl peptide-mediated neutrophil activation...
October 9, 2018: Free Radical Biology & Medicine
Angus Lindsay, Preston M McCourt, Peter Karachunski, Dawn A Lowe, James M Ervasti
Generation of superoxide by xanthine oxidase can be stimulated under ischemic and aberrant calcium homeostasis. Because patients and mice with Duchenne muscular dystrophy (DMD) suffer from ischemia and excessive calcium influx, we tested the hypothesis that xanthine oxidase activity is elevated and contributes to disease pathology. Xanthine oxidase activity was measured by urinary isoxanthopterin in DMD patients at rest and in response to exercise. Urinary isoxanthopterin/creatinine was elevated compared to age-matched controls and Becker muscular dystrophy (BMD) patients...
October 10, 2018: Free Radical Biology & Medicine
Piyawan Paisrisarn, Surapun Tepaamorndech, Mattaka Khongkow, Pongtanawat Khemthong, Panita Kasamechonchung, Wantana Klysubun, Tuksadon Wutikhun, Liping Huang, Kanittha Chantarasakha, Suwimon Boonrungsiman
The present study investigated the effect of lead (Pb) on bone ultrastructure and chemistry using an in vitro bone model. MC3T3-E1 preosteoblasts were differentiated and treated with lead acetate at 0.2, 0.4, 2, 10, and 50 µM. No abnormalities in either cell growth or bone nodule formation were observed with the treated dose of lead acetate. However, Pb treatments could significantly increase Pb accumulation in differentiated osteoblast cultures and upregulate expression of Divalent metal transporter 1 (Dmt1) in a dose dependent manner...
October 9, 2018: Toxicology Letters
Hamid Mollazadeh, Stephen L Atkin, Alexandra E Butler, Massimiliao Ruscica, Cesare R Sirtori, Amirhossein Sahebkar
The endoplasmic reticulum (ER) is critical in protein processing and particularly in ensuring that proteins undergo their correct folding to exert their functionality. What is becoming increasingly clear is that the ER may undergo increasing stress brought about by nutrient deprivation, hypoxia, oxidized lipids, point mutations in secreted proteins, cellular differentiation or significant deviation from metabolic set points, and loss of Ca2+ homeostasis, with detrimental effects on ER-resident calcium-dependent chaperones, alone or in combination...
October 9, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Hardik Makkar, Suresh K Verma, Pritam Kumar Panda, Nandini Pramanik, Ealisha Jha, Mrutyunjay Suar
Improvising bioceramics for enhancing their biocompatibility and physical properties has been a focus area for the dental industry. To further explore this area, this study reports a novel green synthesis and molecular in vitro biocompatibility of calcium aluminosilicate-chitosan nanohybrid (CAS-CH). The nanohybrids were synthesized by using a high energy ball milling (HEBM) technique and then characterized for their physiochemical properties using standard techniques including scanning electron microscopy (SEM) and dynamic light scattering (DLS)...
September 1, 2018: Toxicology Research
Azizah Al-Anazi, Ranjit Parhar, Soad Saleh, Reem Al-Hijailan, Angela Inglis, Mansour Al-Jufan, Mohammed Bazzi, Sarwar Hashmi, Walter Conca, Kate Collison, Futwan Al-Mohanna
AIMS: Hypoxia-induced adipokine release has been attributed mainly to HIF-1α. Here we investigate the role of intracellular calcium and NF-kB in the hypoxia-dependent release of leptin, VEGF, IL-6 and the hypoxia-induced inhibition of adiponectin release in human adipocytes. MAIN METHODS: We used intracellular calcium imaging to compare calcium status in preadipocytes and in adipocytes. We subjected both cell types to hypoxic conditions and measured the release of adipokines induced by hypoxia in the presence and absence of HIF-1α inhibitor YC-1, NF-κ B inhibitor SN50 and intracellular calcium chelator BAPTA-AM...
October 8, 2018: Life Sciences
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