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Calcium oxide

Ivan Luptak, Dominique Croteau, Catherine Valentine, Fuzhong Qin, Deborah Siwik, Daniel Remick, Wilson S Colucci, Ion Hobai
Mice challenged with lipopolysaccharide (LPS) develop cardiomyopathy in a sex- and redox- dependent fashion. Here we extended these studies to the cecal ligation and puncture (CLP) model.We compared male and female FVB mice (wild type, WT) and transgenic littermates over-expressing myocardial catalase (CAT). CLP induced 100% mortality within 4 days, with similar mortality rates in male and female WT and CAT mice. 24 h after CLP, isolated (Langendorff) perfused hearts showed depressed contractility in WT male mice, but not in male CAT or female WT and CAT mice...
August 10, 2018: Shock
Cynthia L Miltenburg, Todd F Duffield, Dorothee Bienzle, Elizabeth L Scholtz, Stephen J LeBlanc
Low total blood calcium concentration after calving has been demonstrated to be a risk factor for reduced neutrophil function. The objective of this study was to evaluate whether administration of an injectable calcium supplement product soon after calving increased neutrophil oxidative burst or phagocytosis capacity. Cows (n = 27) from 4 farms were blocked by parity and randomly assigned to receive either calcium gluconate (35% wt/vol) in combination with calcium glucoheptonate (10% wt/vol; Theracalcium, Vétoquinol Canada Inc...
August 9, 2018: Journal of Dairy Science
Qishi Si, Qi Zhu, Zipeng Xing
In this study, a new core-shell material (CMCS) is prepared with magnesium oxide (MgO) around calcium silicate hydrate (CSH), and CSH is prepared by SiO2 from the red mud. The CMCS simultaneously removes ammonia nitrogen (NH4 + ) and phosphate (PO4 3- ) by chemical precipitation and it can achieve recovery of nitrogen and phosphorus. The removal process of NH4 + and PO4 3- is as follows. First, the shell of MgO is used to remove NH4 + and a part of the PO4 3- by the assisted adsorption and struvite (MgNH4 PO4 ·6H2 O) precipitation method...
August 8, 2018: Ecotoxicology and Environmental Safety
Giuseppe Paradies, Valeria Paradies, Francesca Maria Ruggiero, Giuseppe Petrosillo
Mitochondrial dysfunction plays a central role in myocardial ischemia/reperfusion (I/R) injury. Increased reactive oxygen species production, impaired electron transport chain activity, aberrant mitochondrial dynamics, calcium overload and opening of the mitochondrial permeability transition pore have been proposed as major contributory factors to mitochondrial dysfunction during myocardial I/R injury. Cardiolipin (CL), a mitochondria-specific phospholipid, plays a pivotal role in multiple mitochondrial bioenergetic processes, including respiration and energy conversion, in mitochondrial morphology and dynamics, as well as, in several steps of the apoptotic process...
August 10, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Sofia Fortalezas, Dorinda Marques-da-Silva, Carlos Gutierrez-Merino
Rotenone is a neurotoxin that is an active component of many pesticides which has been shown to induce Parkinsonism in animal models. We show that the cytotoxicity of exposure to nanomolar concentrations of rotenone in cultures of mature cerebellar granule neurons (CGN) in serum-free medium is not due to phagocytosis by glial contamination. A concentration as low as 5.65 ± 0.51 nM of rotenone was enough to trigger 50% cell death of mature CGN in culture after 12 h. The addition of serum proteins to the culture medium attenuated rotenone neurotoxicity, and this can account at least in part for the requirement of higher rotenone concentrations to elicit neuronal cytotoxicity reported in previous works...
August 9, 2018: Neurotoxicity Research
Varun Chaudhary, Yaoying Zhong, Harshida Parmar, Vinay Sharma, Xiao Tan, Raju V Ramanujan
We report an environmentally benign and cost-effective method to produce Fe and Co magnetic metal nanoparticles as well as the Fe/Cao and Co/CaO nanocomposites by using a novel, dry mechanochemical process. Mechanochemical milling of metal oxides with a suitable reducing agent resulted in the production of magnetic metal nanoparticles. The process involved grinding and consequent reduction of low-costing oxide powders, unlike conventional processing techniques involving metal salts or metal complexes. Calcium granules were used as the reducing agent...
August 2018: ChemistryOpen
Johnathon Li, Bryn B Levitan, Silvia Gomez Jimenez, Dietmar Kültz
A data-independent acquisition (DIA) assay library for quantitative analyses of proteome dynamics has been developed for gills of threespine sticklebacks (Gasterosteus aculeatus). A raw spectral library was generated by data-dependent acquisition (DDA) and annotation of tryptic peptides to MSMS spectra and protein database identifiers. The assay library was constructed from the raw spectral library by removal of low-quality, ambiguous, and low-signal peptides. Only unique proteins represented by at least two peptides are included in the assay library, which consists of 1,506 proteins, 5,074 peptides, 5,104 precursors, and 25,322 transitions...
August 9, 2018: Molecular & Cellular Proteomics: MCP
Archana Mahobiya, Thakur Uttam Singh, Soya Rungsung, Tarun Kumar, Gokul Chandrasekaran, Subhashree Parida, Dinesh Kumar
BACKGROUND: Kaempferol, a flavonoid, is the essential part of human diet. Flavonoids have different pharmacological activities like cardioprotective, anti-inflammatory and anti-oxidant. The aim of current study was to investigate vasorelaxant potential of kaempferol on rat isolated pulmonary artery and to assess the underling mechanisms. METHODS: Tension experiments were conducted on both the branches of main pulmonary artery of rats. Experiments were done using isolated organ bath system by recording tension with the help of data acquisition system, Power Lab...
March 26, 2018: Pharmacological Reports: PR
Natalia Di Pietro, Maria Assunta Potenza, Sara Di Silvestre, Francesco Addabbo, Nadia Di Pietrantonio, Pamela Di Tomo, Caterina Pipino, Domitilla Mandatori, Carola Palmerini, Paola Failli, Mario Bonomini, Monica Montagnani, Assunta Pandolfi
The potential role of calcimimetics as vasculotropic agents has been suggested since the discovery that calcium sensing receptors (CaSRs) are expressed in cardiovascular tissues. However, whether this effect is CaSR-dependent or -independent is still unclear. In the present study the vascular activity of calcimimetic R-568 was investigated in mesenteric vascular beds (MVBs) isolated from Spontaneously Hypertensive rats (SHR) and the relative age-matched Wistar-Kyoto (WKY) control rats. Pre-constricted MBVs were perfused with increasing concentrations of R-568 (10 nM- 30 μM) resulting in a rapid dose-dependent vasodilatation...
2018: PloS One
Zongshi Lu, Yuanting Cui, Xing Wei, Peng Gao, Hexuan Zhang, Xiao Wei, Qiang Li, Fang Sun, Zhencheng Yan, Hongting Zheng, Gangyi Yang, Daoyan Liu, Zhiming Zhu
High salt intake is one independent risk factor for cardiac hypertrophy. Polycystic kidney disease 2-like 1 (PKD2L1, also called TRPP3) acts as a sour sensor in taste cells, and its possible role in the cardiovascular system is unknown. Here, we report that knockout of PKD2L1 exacerbated high-salt diet (HSD)-induced cardiac hypertrophy and fibrosis, accompanied by cardiac dysfunction and reduced cardiac mitochondrial oxidative phosphorylation and enzyme activity. Furthermore, knockdown of PKD2L1 led to more serious mitochondrial Ca2+ overload and reduced Ca2+ uptake in cardiomyocytes on high salt loading...
August 7, 2018: Cell Reports
Guido Caluori, Jan Pribyl, Vratislav Cmiel, Martin Pesl, Tomas Potocnak, Ivo Provaznik, Petr Skladal, Vladimir Rotrekl
Calcium ions act like ubiquitous second messengers in a wide amount of cellular processes. In cardiac myocytes, Ca2+ handling regulates the mechanical contraction necessary to the heart pump function. The field of intracellular and intercellular Ca2+ handling, employing in vitro models of cardiomyocytes, has become a cornerstone to understand the role and adaptation of calcium signalling in healthy and diseased hearts. Comprehensive in vitro systems and cell-based biosensors are powerful tools to enrich and speed up cardiac phenotypic and drug response evaluation...
August 6, 2018: Journal of Molecular Recognition: JMR
Qijun Ruan, Lihua Zeng, Jiaoyan Ren, Xiaoquan Yang
There are two long-standing issues that are holding back the full exploitation of food-based double emulsions: (i) unavailability of large-scale equipment to ensure efficient nondestructive two-step emulsification and (ii) limited food-grade ingredients available to replace polyglycerol polyricinoleate (PGPR) as the primary emulsifier. To overcome these, a facile one-step emulsification strategy was developed to generate a food-grade W/O/W double Pickering emulsion by using corn-peptide-functionalized calcium phosphate (CP-CaP) particles as the emulsifier...
August 7, 2018: Food & Function
Mohammad Samiei, Ali Torab, Oldouz Hosseini, Teymur Abbasi, Amir Ardalan Abdollahi, Baharak Divband
Introduction: The aim of this study was to compare the antibacterial effects of two gels containing zinc oxide and zinc oxide/silver nanoparticles and a mixture of calcium hydroxide and 0.12% chlorhexidine as intracanal medicaments in root canals contaminated with Enterococcus faecalis ( E. faecalis ) at different time intervals. Methods and Materials: After preparation and culturing of E. faecalis in 132 single root teeth, the initial count of bacteria was performed...
2018: Iranian Endodontic Journal
Takumi Kishida, Yurie Funakoshi, Yuya Fukuyama, Sari Honda, Toshiya Masuda, Yasuo Oyama
4-Vinylcatechol (4VC) has been identified as an aroma compound in roasted foods, especially coffee. It is also a component in traditional herbal medicines. This compound may be subconsciously ingested through foods and herbs. Recent experimental evidence has shown that 4VC possesses an antioxidative action. However, the antioxidative action of 4VC at cellular levels is not well characterized. The effects of 4VC (0.1-100 µM) were examined on rat thymic lymphocytes without and with oxidative stress induced by 300 µM hydrogen peroxide (H2 O2 )...
August 6, 2018: Drug and Chemical Toxicology
Daniel Alexander Bizjak, Pia Jungen, Wilhelm Bloch, Marijke Grau
AIM: High glycerol cryopreservation of red blood cells (RBCs) reduces metabolic processes at ultralow temperatures but less is known regarding the effect of cryopreservation on RBC nitric oxide (NO) metabolism, haemorheological properties, structural behaviour and membrane fragility. METHODS: Blood from ten healthy participants was sampled, glycerolized and stored at -80 °C (SB). Aliquots were thawed and further processed after 4, 8 and 12 weeks, respectively...
August 3, 2018: Cryobiology
M Joubert, A Manrique, B Cariou, X Prieur
Type 2 diabetes (T2D) is a major risk factor for heart failure (HF). Although the number of cases of myocardial infarction in the T2D population has been reduced by 25% over the last 10 years, the incidence of HF is continuously increasing, making it the most worrying diabetes complication. This strongly reinforces the urgent need for innovative therapeutic interventions to prevent cardiac dysfunction in T2D patients. To this end, epidemiological, imaging and animal studies have aimed to highlight the mechanisms involved in the development of diabetic cardiomyopathy...
July 23, 2018: Diabetes & Metabolism
Rohan Verma, Benjamin I Fischer, Richard L Gregory, Ghaeth H Yassen
INTRODUCTION: We evaluated the radiopacity and antibacterial properties of various concentrations of double antibiotic paste (DAP) containing barium sulfate (BaSO4 ) or zirconium oxide (ZrO2 ) radiopaque agents. METHODS: The radiopacity of 1, 10, and 25 mg/mL DAP containing 30% (w/v) BaSO4 or ZrO2 , DAP-free radiopaque pastes, and commercially available radiopaque calcium hydroxide (Ca[OH]2 ) were evaluated according to ISO 6876/2001 with slight modifications (n = 6 per group)...
August 2, 2018: Journal of Endodontics
A K Putman, J L Brown, J C Gandy, L Wisnieski, L M Sordillo
Metabolic stress occurs in dairy cows when physiologic homeostasis is disrupted as a consequence of aberrant nutrient metabolism, chronic inflammation, and oxidative stress. Early-lactation cows that suffer from metabolic stress are susceptible to health disorders that cause significant production losses. However, there is little information regarding the occurrence and effect of metabolic stress during involution. Therefore, the purpose of this study was to investigate well-known biomarkers associated with metabolic stress in early-lactation cows at various time points during the early dry period when dairy cows also are subjected to dramatic changes in physiologic homeostasis...
August 1, 2018: Journal of Dairy Science
James A Shayman, John J G Tesmer
Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor. Recent studies aided by the delineation of the crystal structure of PLA2G15 have clarified further the catalytic mechanism, sn-1 versus sn-2 specificity, and the basis whereby cationic amphiphilic drugs inhibit its activity...
August 1, 2018: Biochimica et Biophysica Acta
Smith Sylvia B, Wang Jing, Cui Xuezhi, Mysona Barbara, Zhao Jing, Bollinger Kathryn E
Retinal degenerative diseases are major causes of untreatable blindness worldwide and efficacious treatments for these diseases are sorely needed. A novel target for treatment of retinal disease is the transmembrane protein Sigma 1 Receptor (Sig1R). This enigmatic protein is an evolutionary isolate with no known homology to any other protein. Sig1R was originally thought to be an opioid receptor. That notion has been dispelled and more recent pharmacological and molecular studies suggest that it is a pluripotent modulator with a number of biological functions, many of which are relevant to retinal disease...
July 31, 2018: Progress in Retinal and Eye Research
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