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https://www.readbyqxmd.com/read/28735615/new-mechanisms-of-ecm-production-during-wound-healing-a-role-for-parathyroid-hormone-2-receptor-signaling
#1
REVIEW
Traci A Wilgus
Extracellular matrix deposition is required for wound healing. Studies by Sato et al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extracellular matrix production in wounds. Deficiencies in PTH2R or its ligand tuberoinfundibular peptide of 39 residues (TIP39) delayed repair, and TIP39 treatment accelerated healing. TIP39-PTH2R signaling induced decorin expression, which may explain the beneficial effects of PTH2R signaling on healing. These studies identify a novel role for PTH2R signaling in extracellular matrix production...
August 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28454729/activation-of-parathyroid-hormone-2-receptor-induces-decorin-expression-and-promotes-wound-repair
#2
Emi Sato, Ling-Juan Zhang, Robert A Dorschner, Christopher A Adase, Biswa P Choudhury, Richard L Gallo
In this study, we report that TIP39, a parathyroid hormone ligand family member that was recently identified to be expressed in the skin, can induce decorin expression and enhance wound repair. Topical treatment of mice with TIP39 accelerated wound repair, whereas TIP39-deficient mice had delayed repair that was associated with formation of abnormal collagen bundles. To study the potential mechanism responsible for the action of TIP39 in the dermis, fibroblasts were cultured in three-dimensional collagen gels, a process that results in enhanced decorin expression unless activated to differentiate to adipocytes, whereupon these cells reduce expression of several proteoglycans, including decorin...
August 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27000502/the-parathyroid-hormone-second-receptor-pth2r-and-its-ligand-tuberoinfundibular-peptide-of-39-residues-tip39-regulate-intracellular-calcium-and-influence-keratinocyte-differentiation
#3
Emi Sato, Jun Muto, Ling-Juan Zhang, Christopher A Adase, James A Sanford, Toshiya Takahashi, Teruaki Nakatsuji, Ted B Usdin, Richard L Gallo
Genes related to the parathyroid hormone (PTH) influence cutaneous immune defense and development, but the full functions of the PTH family in cutaneous biology remain incompletely understood. In this study, we examined the expression and potential functions of the PTH second receptor (PTH2R) and its ligand, the tuberoinfundibular peptide of 39 residues (TIP39), in the skin. TIP39 and PTH2R mRNA and protein were detectable in both human and mouse skin, and in cultured keratinocytes and adipocytes. TIP39 was observed in the basal layer of human skin, whereas PTH2R was detected in the spinous to granular layer...
July 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26374166/a-genome-wide-association-study-reveals-a-quantitative-trait-locus-for-days-open-on-chromosome-2-in-japanese-black-cattle
#4
Shinji Sasaki, Takayuki Ibi, Takatoshi Kojima, Yoshikazu Sugimoto
Days open (DO), which is the interval from calving to conception, is an important trait related to reproductive performance in cattle. To identify quantitative trait loci for DO in Japanese Black cattle, we conducted a genome-wide association study with 33,303 single nucleotide polymorphisms (SNPs) using 459 animals with extreme DO values selected from a larger group of 15,488 animals. We identified a SNP on bovine chromosome 2 (BTA2) that was associated with DO. After imputation using phased haplotype data inferred from 586 812 SNPs of 1041 Japanese Black cattle, six SNPs associated with DO were located in an 8...
February 2016: Animal Genetics
https://www.readbyqxmd.com/read/26338326/incubation-of-fear-is-regulated-by-tip39-peptide-signaling-in-the-medial-nucleus-of-the-amygdala
#5
Mumeko C Tsuda, Ho-Man Yeung, Jonathan Kuo, Ted B Usdin
UNLABELLED: Fear-related psychopathologies such as post-traumatic stress disorder are characterized by impaired extinction of fearful memories. Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory. Here we examined the anatomical and cellular localization of TIP39 signaling that contributes to the increase in fear memory over time following a traumatic event, called fear memory incubation...
September 2, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26044810/breakpoint-mapping-by-whole-genome-sequencing-identifies-pth2r-gene-disruption-in-a-patient-with-midline-craniosynostosis-and-a-de-novo-balanced-chromosomal-rearrangement
#6
Juwon Kim, Hong-Hee Won, Yoonjung Kim, Jong Rak Choi, Nae Yu, Kyung-A Lee
BACKGROUND: Craniosynostosis (CRS) is a premature closure of calvarial sutures caused by gene mutation or environmental factors or interaction between the two. Only a small proportion of non-syndromic CRS (NSC) patients have a known genetic cause, and thus, it would be meaningful to search for a causative gene disruption for the development NSC. We applied a whole genome sequencing approach on a 15-month-old boy with sagittal and metopic synostosis to identify a gene responsible for the development of the disease...
October 2015: Journal of Medical Genetics
https://www.readbyqxmd.com/read/25462297/pfoa-and-pfos-are-associated-with-reduced-expression-of-the-parathyroid-hormone-2-receptor-pth2r-gene-in-women
#7
Tamara S Galloway, Tony Fletcher, Oliver J Thomas, Ben P Lee, Luke C Pilling, Lorna W Harries
Little is known about interactions between environmental and genetic risk factors for osteoarthritis (OA). Genetic factors include variation or mutation in genes involved in parathyroid hormone signalling. Exposure to the endocrine disrupting chemicals perfluoro-octanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) have been suggested as potential environmental contributors, although evidence to support this association is conflicting. Here we test the hypothesis that PFOA and PFOS may alter the mRNA expression of genes in the parathyroid signalling cascade to provide evidence on possible pathways between these chemicals and OA...
February 2015: Chemosphere
https://www.readbyqxmd.com/read/24552219/expression-of-osteogenic-molecules-in-the-caudate-nucleus-and-gray-matter-and-their-potential-relevance-for-basal-ganglia-calcification-in-hypoparathyroidism
#8
Ravinder Goswami, Tabin Millo, Shruti Mishra, Madhuchhanda Das, Mansi Kapoor, Neeraj Tomar, Soma Saha, Tara Shankar Roy, Vishnubhatla Sreenivas
BACKGROUND: Basal ganglia calcification (BGC) is an interesting example of ectopic calcification in patients with hypoparathyroidism. Its pathogenesis and reasons for predilection of calcification at basal ganglia are not clear. OBJECTIVE: To assess the expression of osteogenesis-related molecules in the caudate nucleus and surface gray matter (an area spared from calcification) and discuss potential relevance of the results in context of BGC in idiopathic hypoparathyroidism...
May 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24378925/variation-in-the-pth2r-gene-is-associated-with-age-related-degenerative-changes-in-the-lumbar-spine
#9
Kristina Åkesson, Max Tenne, Paul Gerdhem, Holger Luthman, Fiona E McGuigan
In the elderly, degenerative changes in the lumbar spine are common, contributing to falsely elevated bone mineral density (BMD) values. The parathyroid hormone (PTH) system plays an important role in the regulation of bone turnover and we explore the hypothesis that polymorphisms (SNPs) within genes in this pathway (PTH, PTHLH, PTH1R and PTH2R) contribute to degenerative manifestations of the spine in elderly women. The study included 1,004 Swedish women aged 75 years from the population-based OPRA cohort who attended follow-up at 5 and 10 years...
January 2015: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/23878240/neuropathic-and-inflammatory-pain-are-modulated-by-tuberoinfundibular-peptide-of-39-residues
#10
Eugene L Dimitrov, Jonathan Kuo, Kenji Kohno, Ted B Usdin
Nociceptive information is modulated by a large number of endogenous signaling agents that change over the course of recovery from injury. This plasticity makes understanding regulatory mechanisms involved in descending inhibition of pain scientifically and clinically important. Neurons that synthesize the neuropeptide TIP39 project to many areas that modulate nociceptive information. These areas are enriched in its receptor, the parathyroid hormone 2 receptor (PTH2R). We previously found that TIP39 affects several acute nociceptive responses, leading us to now investigate its potential role in chronic pain...
August 6, 2013: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/23233446/a-proteomics-and-transcriptomics-approach-to-identify-leukemic-stem-cell-lsc-markers
#11
Francesco Bonardi, Fabrizia Fusetti, Patrick Deelen, Djoke van Gosliga, Edo Vellenga, Jan Jacob Schuringa
Interactions between hematopoietic stem cells and their niche are mediated by proteins within the plasma membrane (PM) and changes in these interactions might alter hematopoietic stem cell fate and ultimately result in acute myeloid leukemia (AML). Here, using nano-LC/MS/MS, we set out to analyze the PM profile of two leukemia patient samples. We identified 867 and 610 unique CD34(+) PM (-associated) proteins in these AML samples respectively, including previously described proteins such as CD47, CD44, CD135, CD96, and ITGA5, but also novel ones like CD82, CD97, CD99, PTH2R, ESAM, MET, and ITGA6...
March 2013: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/23092913/defective-postnatal-endochondral-bone-development-by-chondrocyte-specific-targeted-expression-of-parathyroid-hormone-type-2-receptor
#12
Dibyendu Kumar Panda, David Goltzman, Andrew C Karaplis
The human parathyroid hormone type 2 receptor (PTH2R) is activated by PTH and by tuberoinfundibular peptide of 39 residues (TIP39), the latter likely acting as its natural ligand. Although the receptor is expressed at highest levels in the nervous system, we have observed that both PTH2R and TIP39 are expressed in the newborn mouse growth plate, with the receptor localizing in the resting zone and the ligand TIP39 localizing exclusively in prehypertrophic and hypertrophic chondrocytes. To address the role of PTH2R in postnatal skeletal growth and development, Col2a1-hPTH2R (PTH2R-Tg) transgenic mice were generated...
December 15, 2012: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23060860/the-neuroendocrine-functions-of-the-parathyroid-hormone-2-receptor
#13
Arpád Dobolyi, Eugene Dimitrov, Miklós Palkovits, Ted B Usdin
The G-protein coupled parathyroid hormone 2 receptor (PTH2R) is concentrated in endocrine and limbic regions in the forebrain. Its endogenous ligand, tuberoinfundibular peptide of 39 residues (TIP39), is synthesized in only two brain regions, within the posterior thalamus and the lateral pons. TIP39-expressing neurons have a widespread projection pattern, which matches the PTH2R distribution in the brain. Neuroendocrine centers including the preoptic area, the periventricular, paraventricular, and arcuate nuclei contain the highest density of PTH2R-positive networks...
2012: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/22896038/parathyroid-hormone-stimulates-juxtaglomerular-cell-camp-accumulation-without-stimulating-renin-release
#14
Douglas K Atchison, Pamela Harding, M Cecilia Ortiz-Capisano, Edward L Peterson, William H Beierwaltes
Parathyroid hormone (PTH) is positively coupled to the generation of cAMP via its actions on the PTH1R and PTH2R receptors. Renin secretion from juxtaglomerular (JG) cells is stimulated by elevated intracellular cAMP, and every stimulus that increases renin secretion is thought to do so via increasing cAMP. Thus we hypothesized that PTH increases renin release from primary cultures of mouse JG cells by elevating intracellular cAMP via the PTH1R receptor. We found PTH1R, but not PTH2R, mRNA expressed in JG cells...
October 15, 2012: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/22768871/functional-characterization-and-evolution-of-pth-pthrp-receptors-insights-from-the-chicken
#15
Pedro L C Pinheiro, João C R Cardoso, Deborah M Power, Adelino V M Canário
BACKGROUND: The parathyroid hormone (PTH)-family consists of a group of structurally related factors that regulate calcium and bone homeostasis and are also involved in development of organs such as the heart, mammary gland and immune system. They interact with specific members of family 2 B1 G-protein coupled receptors (GPCRs), which have been characterised in teleosts and mammals. Two PTH/PTHrP receptors, PTH1R and PTH2R exist in mammals and in teleost fish a further receptor PTH3R has also been identified...
July 6, 2012: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/22159128/regulation-of-hypothalamic-signaling-by-tuberoinfundibular-peptide-of-39-residues-is-critical-for-the-response-to-cold-a-novel-peptidergic-mechanism-of-thermoregulation
#16
Eugene L Dimitrov, Yoon Yi Kim, Ted B Usdin
Euthermia is critical for mammalian homeostasis. Circuits within the preoptic hypothalamus regulate temperature, with fine control exerted via descending GABAergic inhibition of presympathetic motor neurons that control brown adipose tissue (BAT) thermogenesis and cutaneous vascular tone. The thermoregulatory role of hypothalamic excitatory neurons is less clear. Here we report peptidergic regulation of preoptic glutamatergic neurons that contributes to temperature regulation. Tuberoinfundibular peptide of 39 residues (TIP39) is a ligand for the parathyroid hormone 2 receptor (PTH2R)...
December 7, 2011: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/21880859/evolution-of-the-vertebrate-pth2-tip39-gene-family-and-the-regulation-of-pth-type-2-receptor-pth2r-and-its-endogenous-ligand-pth2-by-hedgehog-signaling-in-zebrafish-development
#17
Poulomi Bhattacharya, Yi Lin Yan, John Postlethwait, David A Rubin
In mammals, parathyroid hormone (PTH), secreted by parathyroid glands, increases calcium levels in the blood from reservoirs in bone. While mammals have two PTH receptor genes, PTH1R and PTH2R, zebrafish has three receptors, pth1r, pth2r, and pth3r. PTH can activate all three zebrafish Pthrs while PTH2 (alias tuberoinfundibular peptide 39, TIP39) preferentially activates zebrafish and mammalian PTH2Rs. We know little about the roles of the PTH2/PTH2R system in the development of any animal. To determine the roles of PTH2 and PTH2R during vertebrate development, we evaluated their expression patterns in developing zebrafish, observed their phylogenetic and conserved synteny relationships with humans, and described the genomic organization of pth2, pth2r, and pth2r splice variants...
November 2011: Journal of Endocrinology
https://www.readbyqxmd.com/read/20979597/model-of-the-complex-of-parathyroid-hormone-2-receptor-and-tuberoinfundibular-peptide-of-39-residues
#18
Mirna Abraham-Nordling, Bengt Persson, Erik Nordling
BACKGROUND: We aim to propose interactions between the parathyroid hormone-2 receptor (PTH2R) and its ligand the tuberoinfundibular peptide of 39 residues (TIP39) by constructing a homology model of their complex. The two related peptides parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) are compared with the complex to examine their interactions. FINDINGS: In the model, the hydrophobic N-terminus of TIP39 is buried in a hydrophobic part of the central cavity between helices 3 and 7...
2010: BMC Research Notes
https://www.readbyqxmd.com/read/20861230/tuberoinfundibular-peptide-of-39-residues-is-activated-during-lactation-and-participates-in-the-suckling-induced-prolactin-release-in-rat
#19
Melinda Cservenák, Ibolya Bodnár, Ted B Usdin, Miklós Palkovits, György M Nagy, Arpád Dobolyi
Tuberoinfundibular peptide of 39 residues (TIP39) and the PTH-2 receptor (PTH2R) constitute a peptide-receptor neuromodulator system. Based on the abundance of TIP39 fibers and axonal terminals as well as PTH2R-containing neurons and their processes in the hypothalamic para- and periventricular and arcuate nuclei TIP39 has been suggested to play a role in neuroendocrine regulation. We showed previously that TIP39 expression decreased dramatically by adulthood. In the present study, using in situ hybridization histochemistry, real-time RT-PCR, and immunohistochemistry, we found that TIP39 mRNA and peptide expression levels are markedly elevated in the posterior intralaminar complex of the thalamus (PIL) of lactating dams, one of the three locations of TIP39-containing cell bodies in the brain...
December 2010: Endocrinology
https://www.readbyqxmd.com/read/20853513/tuberoinfundibular-peptide-of-39-residues-modulates-the-mouse-hypothalamic-pituitary-adrenal-axis-via-paraventricular-glutamatergic-neurons
#20
Eugene Dimitrov, Ted Björn Usdin
Neurons in the subparafascicular area at the caudal border of the thalamus that contain the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) densely innervate several hypothalamic areas, including the paraventricular nucleus (PVN). These areas contain a matching distribution of TIP39's receptor, the parathyroid hormone receptor 2 (PTH2R). Frequent PTH2R coexpression with a vesicular glutamate transporter (VGlut2) suggests that TIP39 could presynaptically regulate glutamate release. By using immunohistochemistry we found CRH-ir neurons surrounded by PTH2R-ir fibers and TIP39-ir axonal projections in the PVN area of the mouse brain...
November 1, 2010: Journal of Comparative Neurology
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