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papillomavirus classification

James Howard, Raghav C Dwivedi, Liam Masterson, Prasad Kothari, Harry Quon, F Christopher Holsinger
BACKGROUND: More than 400,000 cases of oropharyngeal squamous cell cancer (OPSCC) are diagnosed every year worldwide and this is rising. Much of the increase has been attributed to human papillomavirus (HPV). HPV-positive OPSCC patients are often younger and have significantly improved survival relative to HPV-negative patients. Traditional management of OPSCC has been with radiotherapy with or without chemotherapy, as this was shown to have similar survival to open surgery but with significantly lower morbidity...
December 14, 2018: Cochrane Database of Systematic Reviews
Susan Müller, Sonja C Boy, Terrence A Day, Kelly R Magliocca, Mary S Richardson, Philip Sloan, Wanninayake M Tilakaratne, Rosnah B Zain, Lester D R Thompson
The International Collaboration on Cancer Reporting is a nonprofit organization whose goal is to develop evidence-based, internationally agreed-upon standardized data sets for each cancer site for use throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to the objective of improved patient management and enhanced epidemiologic research. Carcinomas of the oral cavity continue to represent a significant oncologic management burden, especially as changes in alcohol and tobacco use on a global scale contribute to tumor development...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Martin J Bullock, Jonathan J Beitler, Diane L Carlson, Isabel Fonseca, Jennifer L Hunt, Nora Katabi, Philip Sloan, S Mark Taylor, Michelle D Williams, Lester D R Thompson
Standardized, synoptic pathologic reporting for tumors greatly improves communication among clinicians, patients, and researchers, supporting prognostication and comparison about patient outcomes across institutions and countries. The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Within the head and neck region, lymph node excisions and neck dissections are frequently performed as part of the management of head and neck cancers arising from the mucosal sites (sinonasal tract, nasopharynx, oropharynx, hypopharynx, oral cavity, and larynx), along with bone tumors, skin cancers, melanomas, and other tumor categories...
November 30, 2018: Archives of Pathology & Laboratory Medicine
Shin Hye Yoo, Chan-Young Ock, Bhumsuk Keam, Sung Joon Park, Tae Min Kim, Jin Ho Kim, Yoon Kyung Jeon, Eun-Jae Chung, Seong Keun Kwon, J Hun Hah, Tack-Kyun Kwon, Kyeong Chun Jung, Dong-Wan Kim, Hong-Gyun Wu, Myung-Whun Sung, Dae Seog Heo
Background/Aims: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not all HPV-positive HNSCCs are curable, and some patients have a poor prognosis. The purpose of this study was to identify poor prognostic factors in patients with HPV-positive HNSCC. Methods: Patients who received a diagnosis of HNSCC and tested positive for HPV from 2000 to 2015 at a single hospital site (n = 152) were included in this retrospective analysis...
November 16, 2018: Korean Journal of Internal Medicine
Denisse A Gutiérrez, Armando Varela-Ramírez, Miriam Rodríguez-Esquivel, Mónica G Mendoza-Rodríguez, Jorge T Ayala-Sumuano, David Pineda, Efraín Garrido-Guerrero, Florinda Jiménez-Vega, Saúl Aguilar, Miguel Quiñones, María J Nambo, Pedro Chávez-Olmos, Keiko Taniguchi-Ponciano, Daniel Marrero-Rodriguez, Pablo Romero-Morelos, Joanna P Castro, Cindy Bandala, Andrea Carrillo-Romero, Beatriz González-Yebra, Mauricio Salcedo
BACKGROUND: This study presents a prediction of putative miRNA within several Human Papillomavirus (HPV) types by using bioinformatics tools and a strategy based on sequence and structure alignment. Currently, little is known about HPV miRNAs. METHODS: Computational methods have been widely applied in the identification of novel miRNAs when analyzing genome sequences. Here, ten whole-genome sequences from HPV-6, -11, -16, -18, -31, -33, -35, -45, -52, and -58 were analyzed...
November 3, 2018: Archives of Medical Research
Keegan M Lyons, Samantha L Butler
Anal squamous cell carcinoma is a relatively rare diagnosis, but its incidence has continued to rise. Anal squamous cell carcinoma and its precursor lesion, anal intraepithelial neoplasia (AIN), are human papillomavirus (HPV)-associated squamous neoplasias. High-risk HPV subtypes cause cellular proliferation in the anal transformation zone mucosa leading to similar dysplastic changes as seen in the cervix. Unified cytologic and histologic classification systems have emerged for all HPV-associated squamous lesions of the lower anogenital tract due to recent advancements in the understanding of these lesions...
November 2018: Clinics in Colon and Rectal Surgery
Andreia Albuquerque, Elisabete Rios, Rui Medeiros
Histological grading of squamous intraepithelial lesions or intraepithelial neoplasia is fundamental for clinical management and for assessment of the risk of progression. Biomarkers are important for assisting correct grading of these lesions, reducing inter and intraobserver variability and most promising, for prognosis. Although p16 is the most studied biomarker in this setting, there are several other biomarkers that have been studied, reflecting also the need to find a better single or association option that can be more suitable, especially for classification purposes...
October 19, 2018: Histology and Histopathology
Philipp Baumeister, Alessandra Hollmann, Julia Kitz, Artemis Afthonidou, Florian Simon, Julius Shakhtour, Brigitte Mack, Gisela Kranz, Darko Libl, Martin Leu, Markus A Schirmer, Martin Canis, Claus Belka, Horst Zitzelsberger, Ute Ganswindt, Julia Hess, Mark Jakob, Kristian Unger, Olivier Gires
Locally advanced head and neck squamous cell carcinomas (HNSCC) have limited prognosis due to frequent treatment failure. Currently, TNM-classification and human papillomavirus (HPV) infection are the sole clinical prognosticators of outcome. Tumor heterogeneity and stemness based on epithelial-mesenchymal-transition reportedly associate with therapy resistance. The capacity of epithelial marker EpCAM (EpEX), stemness regulator Sox2 and mesenchymal marker vimentin to predict clinical outcome of HSNCC patients was assessed upon immunohistochemistry staining in two cohorts of HNSCC patients treated with surgery and adjuvant radio (chemo) therapy (n = 94) and primary radio (chemo) therapy (n = 94), respectively...
October 1, 2018: Scientific Reports
Vivian M Spaans, Daniëlla A Scheunhage, Bianca Barzaghi, Cor D de Kroon, Gert J Fleuren, Tjalling Bosse, Ekaterina S Jordanova
OBJECTIVE: Recently, the pattern of invasion in usual-type human papillomavirus-associated endocervical adenocarcinoma (AC) was put forward as a novel variable to select patients with favourable prognosis. Based on destructiveness of stromal invasion, three patterns were proposed: A - no destructive stromal invasion, B - focal destructive stromal invasion, and C - diffuse destructive stromal invasion. We aimed to independently validate the clinical significance of this classification-system in 82 AC patients, and explored associations between invasion pattern and somatic mutations...
November 2018: Gynecologic Oncology
Johannes Bründl, Christina Neppl, Thomas Hommer, Wolfgang Otto, Johannes Breyer, Sabine Brookman-May, Florian Weber, Maximilian Burger, Matthias May, Christian Eichelberg
BACKGROUND:  Human papillomavirus (HPV) infection plays an important role in the pathogenesis of penile squamous cell carcinoma (PSCC) in about one third of the affected patients. Initial data indicate that HPV status could facilitate optimised risk stratification and individualised targeted therapy. The polymerase chain reaction (PCR) assay is the reference method for detection of HPV DNA. It is unclear if alternatives such as in situ hybridisation (ISH) or various surrogate markers (defined as immunohistochemical detection of p16INK4a, histological subtype, tumour invasion front, koilocytosis) are sufficient to determine HPV status METHODS:  In this single centre study on 34 patients with PSCC, multiplex nested PCR and ISH were conducted for HPV detection and identification of HPV DNA genotypes...
September 18, 2018: Aktuelle Urologie
Bingxue Huang, Guoyao Sang, Xiaoqing Tuo, Tian Tian, Ainiwaer Abidan, Jianghong Dai
OBJECTIVE: To investigate whether trajectory model can be used to explore the trend of anal human papillomavirus (HPV) infection status among HIV-negative men who have sex with men (MSM). METHODS: HIV-negative MSM were recruited by using the "snowball" method from 1st September 2016 to 30th September 2017 in Urumqi. The subjects were followed-up every six months since enrollment. The cell samples in anal canal were collected and the 37-type HPV test kits were used for identification and classification of HPV infection at both baseline and follow-up visits...
May 25, 2018: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Shayan Cheraghlou, Sina J Torabi, Zain A Husain, Michael D Otremba, Heather A Osborn, Saral Mehra, Wendell G Yarbrough, Barbara A Burtness, Benjamin L Judson
OBJECTIVES: Approximately 3% to 9% of head and neck cancer presents with a metastatic node and no identifiable primary tumor. These cases of head and neck carcinoma of unknown primary (HNCUP) present a therapeutic challenge. Therapy of this disease varies based on factors such as institutional, surgeon, and patient preference. Evidence demonstrating the outcomes associated with these therapies for HNCUP is limited, and among the available series, the tumor human papillomavirus (HPV) status is often ignored...
August 27, 2018: Laryngoscope
Kazuhiro Kobayashi, Kenji Hisamatsu, Natsuko Suzui, Akira Hara, Hiroyuki Tomita, Tatsuhiko Miyazaki
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal lining of the upper aerodigestive tract. Tobacco and alcohol use have been reported to be associated with HNSCC. Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing. HPV-related HNSCCs and HPV-unrelated HNSCCs differ with respect to the molecular mechanisms underlying their oncogenic processes...
August 27, 2018: Journal of Clinical Medicine
Christian Grønhøj, Kathrine Kronberg Jakobsen, David H Jensen, Jacob Rasmussen, Elo Andersen, Jeppe Friborg, Christian von Buchwald
OBJECTIVES: The incidence of human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Currently, data is sparse on the pattern and timing of recurrence. This long-term study concerning both HPV- and p16-status aimed to report predictive factors, pattern, timing of loco-regional recurrence (LRR) and distant recurrence (DR), and survival following recurrence in patients diagnosed with OPSCC. MATERIAL AND METHODS: We included patients diagnosed with OPSCC from 2000 to 2014 in Eastern Denmark, who were treated with curative intent...
August 2018: Oral Oncology
Sarah Deschuymer, Rüveyda Dok, Annouschka Laenen, Esther Hauben, Sandra Nuyts
Background: With the growing interest in treatment de-intensification trials for human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPC), prognostic models have become essential for patient selection. The aim of this paper is to validate and compare the prognostic ability of the TNM 8th edition and previous published risk group classifications of Ang et al. and Rietbergen et al. and to derive a patient selection classification for de-intensification trials. Materials: Patients with HPV+ OPC treated with curative (chemo)radiotherapy between 2004 and 2017 were classified according to the TNM 8th edition, the model of Ang et al...
2018: Frontiers in Oncology
H Nassereddine, C Charpentier, M Bucau, V Joly, L Bienvenu, C Davitian, L Abramowitz, D Benabderrahmane, L Kotelevets, E Chastre, T Lehy, F Walker
OBJECTIVES: The aim of the study was to assess the interest to combine cytological examination and human papillomavirus (HPV) typing of anal and cervical Papanicolaou (Pap) smears of HIV-infected patients on combination antiretroviral therapy (cART), to evaluate whether differences in prevalence exist between anal and cervical squamous intraepithelial lesions in patients with high-risk oncogenic HPV infection. METHODS: Anal and/or cervical Pap smears were obtained by anoscopy and/or colposcopy in 238 subjects recruited consecutively in 2015: anal smears were obtained from 48 male and female patients [42 men; 35 men who have sex with men (MSM)] and cervical smears from 190 female patients...
July 30, 2018: HIV Medicine
Smitha Thammaiah, Mohan C Venkobarao, Hemavathy Sathyavanthan, Angeline S Mirnalini
BACKGROUND: Although human papillomavirus (HPV) is considered as a causative factor in oral squamous cell carcinoma (OSCCs), its pathogenetic role is not well established. Moreover, a limited number of studies have compared the techniques of detecting the HPV infection in OSCC. This study aimed at the detection of HPV 16 E6 and E7 DNA in OSCC by quantitative polymerase chain reaction (qPCR) technique. METHODOLOGY: This retrospective study included 297 tissue sections obtained from histopathologically confirmed OSCC patients...
July 30, 2018: Journal of Oral Pathology & Medicine
Dorian R A Swarts, Quirinus J M Voorham, Annina P van Splunter, Saskia M Wilting, Daoud Sie, Divera Pronk, Marc van Beurden, Daniëlle A M Heideman, Peter J F Snijders, Chris J L M Meijer, Renske D M Steenbergen, Maaike C G Bleeker
Vulvar squamous cell carcinoma (VSCC) and precancerous vulvar intraepithelial neoplasia (VIN) can develop through human papillomavirus (HPV)-dependent and -independent pathways, indicating a heterogeneous disease. Only a minority of VIN progress, but current clinicopathological classifications are insufficient to predict the cancer risk. Here we analyzed copy number alterations (CNA) to assess the molecular heterogeneity of vulvar lesions in relation to HPV and cancer risk. HPV-status and CNA by means of whole-genome next-generation shallow-sequencing were assessed in VSCC and VIN...
September 2018: Cancer Medicine
Josephine Patricia Dhar, Lynnette Essenmacher, Renee Dhar, Neli Ragina, Robert J Sokol
BACKGROUND/OBJECTIVE: Women with systemic lupus erythematosus (SLE) are at increased risk for cervical neoplasia likely due to infection with high-risk human papillomavirus (HR-HPV) and should be considered for HPV vaccination. We sought to determine frequency of HR-HPV infection and uptake of HPV vaccination in our regional female lupus population. METHODS: For this retrospective cohort study, data were analyzed from our electronic health records EPIC for women with International Classification of Diseases -10 or International Classification of Diseases -9 billing codes for SLE seen June 6, 2007, to May 1, 2017...
July 20, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Amanda R Kahl, Mary E Charlton, Nitin A Pagedar, Steven M Sperry, Bobbi Matt, Charles Platz, Charles F Lynch
BACKGROUND: Surveillance, Epidemiology, and End Results Cancer Registries (SEER) began collecting human papillomavirus (HPV) status for upper aerodigestive tract cancers in 2010. However, classification of p16-testing was not included in the Collaborative Stage coding guidelines, potentially leading to inconsistent coding. METHODS: The HPV values for Iowa patients with oropharyngeal cancers (n = 824) were recoded based on modified guidelines that included p16 test results, and compared with the original guidelines...
October 2018: Head & Neck
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