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papillomavirus classification

Philipp Baumeister, Alessandra Hollmann, Julia Kitz, Artemis Afthonidou, Florian Simon, Julius Shakhtour, Brigitte Mack, Gisela Kranz, Darko Libl, Martin Leu, Markus A Schirmer, Martin Canis, Claus Belka, Horst Zitzelsberger, Ute Ganswindt, Julia Hess, Mark Jakob, Kristian Unger, Olivier Gires
Locally advanced head and neck squamous cell carcinomas (HNSCC) have limited prognosis due to frequent treatment failure. Currently, TNM-classification and human papillomavirus (HPV) infection are the sole clinical prognosticators of outcome. Tumor heterogeneity and stemness based on epithelial-mesenchymal-transition reportedly associate with therapy resistance. The capacity of epithelial marker EpCAM (EpEX), stemness regulator Sox2 and mesenchymal marker vimentin to predict clinical outcome of HSNCC patients was assessed upon immunohistochemistry staining in two cohorts of HNSCC patients treated with surgery and adjuvant radio (chemo) therapy (n = 94) and primary radio (chemo) therapy (n = 94), respectively...
October 1, 2018: Scientific Reports
Vivian M Spaans, Daniëlla A Scheunhage, Bianca Barzaghi, Cor D de Kroon, Gert J Fleuren, Tjalling Bosse, Ekaterina S Jordanova
OBJECTIVE: Recently, the pattern of invasion in usual-type human papillomavirus-associated endocervical adenocarcinoma (AC) was put forward as a novel variable to select patients with favourable prognosis. Based on destructiveness of stromal invasion, three patterns were proposed: A - no destructive stromal invasion, B - focal destructive stromal invasion, and C - diffuse destructive stromal invasion. We aimed to independently validate the clinical significance of this classification-system in 82 AC patients, and explored associations between invasion pattern and somatic mutations...
September 24, 2018: Gynecologic Oncology
Johannes Bründl, Christina Neppl, Thomas Hommer, Wolfgang Otto, Johannes Breyer, Sabine Brookman-May, Florian Weber, Maximilian Burger, Matthias May, Christian Eichelberg
BACKGROUND:  Human papillomavirus (HPV) infection plays an important role in the pathogenesis of penile squamous cell carcinoma (PSCC) in about one third of the affected patients. Initial data indicate that HPV status could facilitate optimised risk stratification and individualised targeted therapy. The polymerase chain reaction (PCR) assay is the reference method for detection of HPV DNA. It is unclear if alternatives such as in situ hybridisation (ISH) or various surrogate markers (defined as immunohistochemical detection of p16INK4a, histological subtype, tumour invasion front, koilocytosis) are sufficient to determine HPV status METHODS:  In this single centre study on 34 patients with PSCC, multiplex nested PCR and ISH were conducted for HPV detection and identification of HPV DNA genotypes...
September 18, 2018: Aktuelle Urologie
Bingxue Huang, Guoyao Sang, Xiaoqing Tuo, Tian Tian, Ainiwaer Abidan, Jianghong Dai
OBJECTIVE: To investigate whether trajectory model can be used to explore the trend of anal human papillomavirus (HPV) infection status among HIV-negative men who have sex with men (MSM). METHODS: HIV-negative MSM were recruited by using the "snowball" method from 1st September 2016 to 30th September 2017 in Urumqi. The subjects were followed-up every six months since enrollment. The cell samples in anal canal were collected and the 37-type HPV test kits were used for identification and classification of HPV infection at both baseline and follow-up visits...
May 25, 2018: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Shayan Cheraghlou, Sina J Torabi, Zain A Husain, Michael D Otremba, Heather A Osborn, Saral Mehra, Wendell G Yarbrough, Barbara A Burtness, Benjamin L Judson
OBJECTIVES: Approximately 3% to 9% of head and neck cancer presents with a metastatic node and no identifiable primary tumor. These cases of head and neck carcinoma of unknown primary (HNCUP) present a therapeutic challenge. Therapy of this disease varies based on factors such as institutional, surgeon, and patient preference. Evidence demonstrating the outcomes associated with these therapies for HNCUP is limited, and among the available series, the tumor human papillomavirus (HPV) status is often ignored...
August 27, 2018: Laryngoscope
Kazuhiro Kobayashi, Kenji Hisamatsu, Natsuko Suzui, Akira Hara, Hiroyuki Tomita, Tatsuhiko Miyazaki
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal lining of the upper aerodigestive tract. Tobacco and alcohol use have been reported to be associated with HNSCC. Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing. HPV-related HNSCCs and HPV-unrelated HNSCCs differ with respect to the molecular mechanisms underlying their oncogenic processes...
August 27, 2018: Journal of Clinical Medicine
Christian Grønhøj, Kathrine Kronberg Jakobsen, David H Jensen, Jacob Rasmussen, Elo Andersen, Jeppe Friborg, Christian von Buchwald
OBJECTIVES: The incidence of human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Currently, data is sparse on the pattern and timing of recurrence. This long-term study concerning both HPV- and p16-status aimed to report predictive factors, pattern, timing of loco-regional recurrence (LRR) and distant recurrence (DR), and survival following recurrence in patients diagnosed with OPSCC. MATERIAL AND METHODS: We included patients diagnosed with OPSCC from 2000 to 2014 in Eastern Denmark, who were treated with curative intent...
August 2018: Oral Oncology
Sarah Deschuymer, Rüveyda Dok, Annouschka Laenen, Esther Hauben, Sandra Nuyts
Background: With the growing interest in treatment de-intensification trials for human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPC), prognostic models have become essential for patient selection. The aim of this paper is to validate and compare the prognostic ability of the TNM 8th edition and previous published risk group classifications of Ang et al. and Rietbergen et al. and to derive a patient selection classification for de-intensification trials. Materials: Patients with HPV+ OPC treated with curative (chemo)radiotherapy between 2004 and 2017 were classified according to the TNM 8th edition, the model of Ang et al...
2018: Frontiers in Oncology
H Nassereddine, C Charpentier, M Bucau, V Joly, L Bienvenu, C Davitian, L Abramowitz, D Benabderrahmane, L Kotelevets, E Chastre, T Lehy, F Walker
OBJECTIVES: The aim of the study was to assess the interest to combine cytological examination and human papillomavirus (HPV) typing of anal and cervical Papanicolaou (Pap) smears of HIV-infected patients on combination antiretroviral therapy (cART), to evaluate whether differences in prevalence exist between anal and cervical squamous intraepithelial lesions in patients with high-risk oncogenic HPV infection. METHODS: Anal and/or cervical Pap smears were obtained by anoscopy and/or colposcopy in 238 subjects recruited consecutively in 2015: anal smears were obtained from 48 male and female patients [42 men; 35 men who have sex with men (MSM)] and cervical smears from 190 female patients...
July 30, 2018: HIV Medicine
Smitha Thammaiah, Mohan C Venkobarao, Hemavathy Sathyavanthan, Angeline S Mirnalini
BACKGROUND: Although human papillomavirus (HPV) is considered as a causative factor in oral squamous cell carcinoma (OSCCs), its pathogenetic role is not well established. Moreover, a limited number of studies have compared the techniques of detecting the HPV infection in OSCC. This study aimed at the detection of HPV 16 E6 and E7 DNA in OSCC by quantitative polymerase chain reaction (qPCR) technique. METHODOLOGY: This retrospective study included 297 tissue sections obtained from histopathologically confirmed OSCC patients...
July 30, 2018: Journal of Oral Pathology & Medicine
Dorian R A Swarts, Quirinus J M Voorham, Annina P van Splunter, Saskia M Wilting, Daoud Sie, Divera Pronk, Marc van Beurden, Daniëlle A M Heideman, Peter J F Snijders, Chris J L M Meijer, Renske D M Steenbergen, Maaike C G Bleeker
Vulvar squamous cell carcinoma (VSCC) and precancerous vulvar intraepithelial neoplasia (VIN) can develop through human papillomavirus (HPV)-dependent and -independent pathways, indicating a heterogeneous disease. Only a minority of VIN progress, but current clinicopathological classifications are insufficient to predict the cancer risk. Here we analyzed copy number alterations (CNA) to assess the molecular heterogeneity of vulvar lesions in relation to HPV and cancer risk. HPV-status and CNA by means of whole-genome next-generation shallow-sequencing were assessed in VSCC and VIN...
September 2018: Cancer Medicine
Josephine Patricia Dhar, Lynnette Essenmacher, Renee Dhar, Neli Ragina, Robert J Sokol
BACKGROUND/OBJECTIVE: Women with systemic lupus erythematosus (SLE) are at increased risk for cervical neoplasia likely due to infection with high-risk human papillomavirus (HR-HPV) and should be considered for HPV vaccination. We sought to determine frequency of HR-HPV infection and uptake of HPV vaccination in our regional female lupus population. METHODS: For this retrospective cohort study, data were analyzed from our electronic health records EPIC for women with International Classification of Diseases -10 or International Classification of Diseases -9 billing codes for SLE seen June 6, 2007, to May 1, 2017...
July 20, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Amanda R Kahl, Mary E Charlton, Nitin A Pagedar, Steven M Sperry, Bobbi Matt, Charles Platz, Charles F Lynch
BACKGROUND: Surveillance, Epidemiology, and End Results Cancer Registries (SEER) began collecting human papillomavirus (HPV) status for upper aerodigestive tract cancers in 2010. However, classification of p16-testing was not included in the Collaborative Stage coding guidelines, potentially leading to inconsistent coding. METHODS: The HPV values for Iowa patients with oropharyngeal cancers (n = 824) were recoded based on modified guidelines that included p16 test results, and compared with the original guidelines...
June 22, 2018: Head & Neck
Koenraad Van Doorslaer, Zigui Chen, Hans-Ulrich Bernard, Paul K S Chan, Rob DeSalle, Joakim Dillner, Ola Forslund, Takeshi Haga, Alison A McBride, Luisa L Villa, Robert D Burk, Ictv Report Consortium
The Papillomaviridae is a family of small, non-enveloped viruses with double-stranded DNA genomes of 5 748 to 8 607 bp. Their classification is based on pairwise nucleotide sequence identity across the L1 open reading frame. Members of the Papillomaviridae primarily infect mucosal and keratinised epithelia, and have been isolated from fish, reptiles, birds and mammals. Despite a long co-evolutionary history with their hosts, some papillomaviruses are pathogens of their natural host species. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Papillomaviridae, which is available at http://www...
August 2018: Journal of General Virology
Mario Koopmann, Claudia Rudack, Daniel Weiss, Markus Stenner
BACKGROUND: Squamous cell carcinoma of the nasal vestibule is a rare entity. In consequence disagreement in etiology, staging system and therapy of primary tumor with or without adjuvant treatment of regional lymph nodes are apparent. METHODS: Pubmed-Recherche of relevant literature concerning: lymphatic drainage, metastases, incidence, risk factors (leather, nickel, nicotine, human papillomavirus, Staging system (UICC, AJCC, Wang's system), therapy of the primary tumor, regional lymph nodes and immunohistochemistry...
June 2018: Laryngo- Rhino- Otologie
A Picard, L Arowas, L Piroth, I Heard, T Ferry
OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC), mainly due to smoking, is one of the leading causes of cancer deaths. However, an increasing number of tumors - especially oropharyngeal cancer - are reported in non-smokers in association with the human papillomavirus (HPV). As HIV-infected individuals are particularly at risk of HPV-related disease, we aimed to describe the burden of HNSCC in this population. METHODS: Retrospective chart review of patients from HIV clinics diagnosed with HNSCC between 2004 and 2014...
June 7, 2018: Médecine et Maladies Infectieuses
Anjelica Hodgson, Kay J Park, Bojana Djordjevic, Brooke E Howitt, Marisa R Nucci, Esther Oliva, Simona Stolnicu, Bin Xu, Robert A Soslow, Carlos Parra-Herran
The current World Health Organization (WHO) classification for endocervical adenocarcinoma (EA) is based on descriptive morphologic characteristics; however, it does not fully reflect our current knowledge of the diverse pathogenesis of cervical glandular neoplasia. A novel classification system, the International Endocervical Adenocarcinoma Criteria and Classification (IECC), which incorporates etiology and biological behavior into the morphologic scheme, has been recently proposed. We aimed to validate the IECC by assessing its interobserver reproducibility in comparison to the WHO system...
June 5, 2018: American Journal of Surgical Pathology
W Katherine Yih, Judith C Maro, Michael Nguyen, Meghan A Baker, Carolyn Balsbaugh, David V Cole, Inna Dashevsky, Adamma Mba-Jonas, Martin Kulldorff
The self-controlled tree-temporal scan statistic-a new signal-detection method-can evaluate whether any of a wide variety of health outcomes are temporally associated with receipt of a specific vaccine, while adjusting for multiple testing. Neither health outcomes nor postvaccination potential periods of increased risk need be prespecified. Using US medical claims data in the Food and Drug Administration's Sentinel system, we employed the method to evaluate adverse events occurring after receipt of quadrivalent human papillomavirus vaccine (4vHPV)...
June 1, 2018: American Journal of Epidemiology
Daiji Takamoto, Takashi Kawahara, Jun Kasuga, Takeshi Sasaki, Masahiro Yao, Yasushi Yumura, Hiroji Uemura
Primary penile cancer is a rare disease. Higher incidence rates occur in underdeveloped countries. Many studies have suggested an association between human papillomavirus (HPV) infection and penile cancer. Although HPV can affect the squamous epithelium of the male genitalia similarly to the female genital tract, the association between penile cancer and HPV remains unclear. In the present study, the HPV gene expression was examined in penile cancer tissue using in situ hybridization (ISH). The present study included 41 cases in which penectomy was performed and 3 cases in which tumor resection was performed to treat pathologically-diagnosed penile cancer at Yokohama City University Medical Center, and its 7 affiliated hospitals between April 1990 and March 2010...
May 2018: Oncology Letters
I Troussier, G Klausner, E Blais, P Giraud, L Lahmi, C Pflumio, J-C Faivre, L Geoffrois, E Babin, S Morinière, P Maingon, J Thariat
The definition of nodal and/or mucosal target volumes for radiation therapy for lymphadenopathies of unknown primary is controversial. Target volumes may include all nodal areas bilaterraly and be pan-mucosal or unilateral, selective, including the sole oropharyngeal mucosa. This review presents current recommendations in light of changes in the TNM classification, Human papillomavirus status and therapeutic advances. We conducted a systematic review of the literature with the following keywords: lymphadenopathy; head and neck; unknown primary and radiation therapy...
September 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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