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Cystic fibrosis sinus disease

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https://www.readbyqxmd.com/read/30328698/perioperative-risk-factors-associated-with-morbidity-and-mortality-following-pediatric-inpatient-sinus-surgery
#1
Brittany N Burton, Sapideh Gilani, Milli Desai, Robert Saddawi-Konefka, Lindia Willies-Jacobo, Rodney A Gabriel
OBJECTIVES: Pediatric sinus surgery is indicated for a wide range of sinonasal and skull base pathologies, but it is most commonly performed for recalcitrant chronic rhinosinusitis or complicated acute sinusitis. The authors aim to report medical risk factors of morbidity and mortality following inpatient sinus surgery in the pediatric population. METHODS: Using data from the Kids' Inpatient Database from 2003 to 2012, patients with International Classification of Diseases, Ninth Revision, procedure codes for primary sinus surgery were identified...
October 17, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/30316653/-ageing-with-cystic-fibrosis-classical-and-emerging-comorbidities-in-adults-with-cystic-fibrosis
#2
L Regard, H Lafoeste, C Martin, G Chassagnon, P-R Burgel
Cystic fibrosis (CF) is a genetic disease with pulmonary involvement being predominant and often leading to respiratory failure and premature death. Non-pulmonary complications related to CF transmembrane conductance regulator (CFTR) defect are numerous and account for significant morbidity (exocrine pancreatic insufficiency, diabetes, CF-related liver disease, chronic sinusitis, osteoporosis). Improvement in patients' care led to a continuous increase in life expectancy, with a subsequent increase in the number of adult CF patients worldwide...
October 10, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/30300208/update-on-sinus-disease-in-children-with-cystic-fibrosis-advances-in-treatment-modalities-microbiology-and-health-related-quality-of-life-instruments
#3
Jean-Nicolas Gallant, Margaret B Mitchell, Frank W Virgin
PURPOSE OF REVIEW: There is a lack of consensus with regards to the diagnosis and treatment of sinus disease in children with cystic fibrosis. Here, we review literature from the past 18 months in order to highlight the way forward in this contentious field. RECENT FINDINGS: Most of the literature (from the past 18 months) on sinus disease in pediatric cystic fibrosis focused on treatment approaches, bacteriology and immunology, and health-related quality-of-life (HRQOL) instruments...
October 8, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/30284279/loss-of-microbial-niche-specificity-between-the-upper-and-lower-airways-in-patients-with-cystic-fibrosis
#4
Steven D Pletcher, Andrew N Goldberg, Emily K Cope
OBJECTIVES/HYPOTHESIS: To determine the relationship between mucosal-associated sinus and bronchial microbiota in cystic fibrosis (CF) patients compared to non-CF patients with chronic rhinosinusitis (CRS). STUDY DESIGN: Case series. METHODS: We examined the microbial composition of 52 paired sinus and bronchial brushings from 26 patients with CRS. Paired airway samples from nine subjects with CF were compared with samples from 17 non-CF-CRS disease control patients...
October 3, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30152192/resveratrol-and-ivacaftor-are-additive-g551d-cftr-channel-potentiators-therapeutic-implications-for-cystic-fibrosis-sinus-disease
#5
Do-Yeon Cho, Shaoyan Zhang, Ahmed Lazrak, Jessica W Grayson, Jaime A Peña Garcia, Daniel F Skinner, Dong Jin Lim, Calvin Mackey, Catherine Banks, Sadis Matalon, Bradford A Woodworth
BACKGROUND: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in defective Cl- transport and cause chronic bacterial infections in the upper and lower airways of cystic fibrosis (CF) patients. Ivacaftor is a CFTR potentiator that improves Cl- transport in CF patients with at least 1 copy of the G551D mutation. Resveratrol is also a potent CFTR potentiator that increases determinants of mucociliary transport. The objective of this study is to determine whether resveratrol and ivacaftor improve Cl- secretion in G551D CFTR over either agent alone...
August 27, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30126729/feasibility-study-of-bilateral-radical-ethmoidectomy-in-ambulatory-surgery
#6
M Kérimian, P-L Bastier, N Réville, S Fierens, L de Gabory
OBJECTIVES: To assess the feasibility of bilateral radical ethmoidectomy in ambulatory surgery by risk analysis, and to calculate possible medico-economic savings. METHODS: This study was performed retrospectively over a 2-year period and prospectively for 1 year. It included all patients undergoing bilateral ethmoidectomy, associated to sphenoidotomy and/or septoplasty or not, in a university hospital department. Data were collected on demographics, disease etiology, previous surgery, operative details, postoperative course, complications and satisfaction assessed by questionnaire at days 1 and 30...
August 17, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/30112923/effect-of-endoscopic-sinus-surgery-on-bronchiectasis-patients-with-chronic-rhinosinusitis
#7
Jesada Kanjanaumporn, Peter H Hwang
Background The concept of unified airway disease has linked bronchiectasis with chronic rhinosinusitis (CRS), much in the same way as in asthma and CRS. Although the outcomes of endoscopic sinus surgery (ESS) on comorbid asthma have been relatively well studied, the outcomes of ESS on comorbid bronchiectasis have rarely been examined. Objective We sought to determine sinonasal and pulmonary clinical outcomes of ESS in bronchiectasis patients with CRS. Method We reviewed all bronchiectasis patients who had ESS for CRS at our institution from 2006 to present...
September 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29797646/the-burden-of-sinus-disease-in-cystic-fibrosis-lung-transplant-recipients
#8
Letizia Corinna Morlacchi, Mark Greer, Igor Tudorache, Francesco Blasi, Tobias Welte, Axel Haverich, Jochen G Mainz, Jens Gottlieb
INTRODUCTION: Sinus disease (SD) in cystic fibrosis (CF) is a known risk factor for disease progression, the upper airways (UAW) being a site of primary colonization with Pseudomonas aeruginosa. UAW may function as reservoir for graft colonization after lung transplantation (LuTx), increasing risk of rejection. Aims of this study were to assess the burden of sinus disease in CF LuTx recipients, considering patient-reported symptoms, endoscopically documented signs and microbiological isolates, comparing colonization between upper and lower airways...
May 24, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29771095/-a-progress-of-macrolides-therapy-for-chronic-rhinosinusitis
#9
REVIEW
S Shen, C S Wang
Macrolides are a type of antibiotics with macrocyclic lactone ring, which have been commonly used in the treatment of diffuse panbronchiolitis, chronic obstructive pulmonary disease, bronchial asthma, cystic fibrosis and other diseases. Macrolides not only have effect on antibacterial, but also effect on anti-inflammatory and immunoregulation. Chronic rhinosinusitis (CRS) is a common disease entity of infectious and inflammatory diseases that involved in nasal cavity and nasal sinuses, with various clinical phenotypes...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29519311/a-24-year-old-woman-with-precipitous-respiratory-failure-after-lung-transplantation
#10
Whittney A Warren, Domingo Franco-Palacios, Christopher S King, Oksana A Shlobin, Steven D Nathan, Shalika B Katugaha, Haresh Mani, A Whitney Brown
A 24-year-old woman with ΔF508/Y1092X cystic fibrosis (CF) complicated by severe obstructive lung disease (FEV1 of 30% predicted) was admitted for IV antibiotics for planned sinus surgery resulting from severe chronic sinusitis causing frequent exacerbations and declining lung function. She had persistent airway infection with multidrug-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and growth of a fungus presumed to be an airway colonizer, identified as Stephanoascus ciferrii 1 year before presentation...
March 2018: Chest
https://www.readbyqxmd.com/read/29504898/on-burkholderiales-order-microorganisms-and-cystic-fibrosis-in-russia
#11
Olga L Voronina, Marina S Kunda, Natalia N Ryzhova, Ekaterina I Aksenova, Natalia E Sharapova, Andrey N Semenov, Elena L Amelina, Alexandr G Chuchalin, Alexandr L Gintsburg
BACKGROUND: Microbes infecting cystic fibrosis patients' respiratory tract are important in determining patients' functional status. Representatives of Burkholderiales order are the most dangerous. The goal of our investigation was to reveal the diversity of Burkholderiales, define of their proportion in the microbiome of various parts of respiratory tract and determine the pathogenicity of the main representatives. RESULTS: In more than 500 cystic fibrosis patients, representing all Federal Regions of Russia, 34...
February 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29362708/upper-airway-involvement-in-bronchiectasis-is-marked-by-early-onset-and-allergic-features
#12
Michal Shteinberg, Najwan Nassrallah, Jenny Jrbashyan, Nechama Uri, Nili Stein, Yochai Adir
The association of bronchiectasis with chronic rhinosinusitis (CRS) has been reported. However, apart from primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), predisposing conditions have not been established. We aimed to define clinical and laboratory features that differentiate patients with bronchiectasis with upper airway symptoms (UASs) and without PCD from patients without UASs. We reviewed charts of adults with bronchiectasis, excluding CF and PCD. UASs were defined as nasal discharge most days of the year, sinusitis or nasal polyps...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29319936/submucosal-gland-mucus-strand-velocity-is-decreased-in-chronic-rhinosinusitis
#13
Kiranya E Tipirneni, Shaoyan Zhang, Do-Yeon Cho, Jessica Grayson, Daniel F Skinner, Calvin Mackey, Lindsay Moore, Denzel Cole, Catherine G Banks, Bradford A Woodworth
BACKGROUND: Chronic rhinosinusitis (CRS) may be initiated by innately impaired host defense mechanisms that predispose the upper airways to infection. Recent evidence suggests tethering of submucosal gland mucus strands represents an inciting event within cystic fibrosis (CF) airways, occurring prior to onset of chronic infection. Submucosal gland hypertrophy and defective mucociliary clearance (MCC) are present in actively inflamed sinuses, but mucus strand velocity may also be affected as a secondary event, further contributing to chronic disease...
April 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29289454/audiometric-assessment-of-pediatric-patients-with-cystic-fibrosis
#14
Kathryn L Kreicher, Michael J Bauschard, Clarice S Clemmens, Concetta Maria Riva, Ted A Meyer
BACKGROUND: The purpose of this study was to evaluate hearing impairment in pediatric patients with cystic fibrosis (CF). METHODS: This is a retrospective analysis of the AudGen database generated by Children's Hospital of Philadelphia. Audiograms were analyzed for type of hearing loss (HL), pure-tone-average (PTA), laterality, and change in hearing over time. Medical charts were reviewed to identify factors that influence development and progression of hearing loss...
May 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29240302/correlation-between-sinus-and-lung-cultures-in-lung-transplant-patients-with-cystic-fibrosis
#15
Kevin J Choi, Tracy Z Cheng, Adam L Honeybrook, Alice L Gray, Laurie D Snyder, Scott M Palmer, Ralph Abi Hachem, David W Jang
BACKGROUND: Lung transplantation has revolutionized the treatment of end-stage pulmonary disease due to cystic fibrosis. However, infection of the transplanted lungs can lead to serious complications, including graft failure and death. Although many of these patients have concurrent sinusitis, it is unclear whether bacteria from the sinuses can infect the allograft. METHODS: This is a single-institution retrospective study of all patients who underwent lung transplantation for cystic fibrosis from 2005 to 2015 at Duke University Hospital...
March 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29210505/pulmonary-aspiration-of-sinus-secretions-in-patients-with-cystic-fibrosis
#16
Jacob Nelson, Peter Karempelis, Jordan Dunitz, Ryan Hunter, Holly Boyer
BACKGROUND: Indirect evidence suggests that sinonasal secretions are aspirated into the lungs of patients with cystic fibrosis (CF), contributing to infection, subsequent tissue damage, and decreased lung function. Our objective is to determine whether sinonasal secretions are transferred to the lungs in patients with CF-related sinus disease and healthy subjects, particularly in the recumbent position and during sleep. METHODS: We performed a prospective, controlled trial to detect pulmonary aspiration of radiolabeled albumin applied to the nasal mucosa of study subjects with chronic sinusitis related to CF and control subjects without sinus disease...
March 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29193105/correlations-between-cystic-fibrosis-genotype-and-sinus-disease-severity-in-chronic-rhinosinusitis
#17
Waleed M Abuzeid, Changeun Song, Judd H Fastenberg, Christina H Fang, Noel Ayoub, Elina Jerschow, Paul K Mohabir, Peter H Hwang
OBJECTIVE: Cystic fibrosis (CF) patients commonly develop chronic rhinosinusitis (CRS). The impact of the most common cystic fibrosis transmembrane conductance regulator (CFTR) mutation, F508del, on the severity of sinonasal disease remains inconclusive. The objective of this study is to evaluate the impact of CFTR genotype functional classification on sinonasal disease severity in patients with CRS. METHODS: Retrospective chart review of patients with CF who underwent endoscopic sinus surgery for chronic rhinosinusitis from 1998 to 2015...
August 2018: Laryngoscope
https://www.readbyqxmd.com/read/29182491/improved-lung-function-after-sinus-surgery-in-cystic-fibrosis-patients-with-moderate-obstruction
#18
Sabrina Khalfoun, Dmitry Tumin, Maroun Ghossein, Meredith Lind, Don Hayes, Stephen Kirkby
Objectives Cystic fibrosis (CF) is characterized by infection and inflammation of the sinorespiratory tract. Functional endoscopic sinus surgery (FESS) is an option for patients with severe sinusitis. We sought to evaluate pulmonary function testing after FESS in pediatric and adult patients with CF. Study Design Retrospective chart review using data from all patients with CF who underwent FESS from January 2009 to July 2014. Setting Patients were from a single institution. Subjects and Methods Data were extracted for 181 patients and 320 surgeries...
February 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29094071/clinical-chronic-rhinosinusitis-outcomes-in-pediatric-patients-with-cystic-fibrosis
#19
REVIEW
Frank W Virgin
Objectives: Chronic rhinosinusitis and nasal polyposis are common conditions in cystic fibrosis (CF). Approximately 2-3% of pediatric CF patients per year have sinus disease requiring surgery. It has been well established that there is a significant negative impact on quality of life associated with chronic rhinosinusitis (CRS) in the non-CF patient population. However, the impact of CRS on the pediatric CF population remains uncertain. The purpose of this article is to review the current state of outcome measures for CRS in pediatric CF patients...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29021032/chapter-6-nasal-polyps
#20
Russell A Settipane, Anju T Peters, Alexander G Chiu
Nasal polyps occur in 1-4% of the population, usually occurring in the setting of an underlying local or systemic disease. The most common associated condition is chronic rhinosinusitis (CRS). A high prevalence of nasal polyps is also seen in allergic fungal rhinosinusitis, aspirin-exacerbated respiratory disease, Churg-Strauss syndrome, and cystic fibrosis. In the setting of CRS, nasal polyps are not likely to be cured by either medical or surgical therapy; however, control is generally attainable. The best medical evidence supports the use of intranasal corticosteroids for maintenance therapy and short courses of oral corticosteroids for exacerbations...
May 1, 2013: American Journal of Rhinology & Allergy
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