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Emily J Cicali, Kathryn Blake, Yan Gong, Edward B Mougey, Hadeel Al-Atrash, Nancy Chambers, Jolanda Denham, Jonathan Evans, Donald E George, Roberto Gomez, Pablo Palomo, Salik Taufiq, Julie A Johnson, John J Lima, James P Franciosi
The efficacy of proton pump inhibitor (PPI) medications is highly dependent on plasma concentrations, which varies considerably due to cytochrome P450 (CYP2C19) genetic variation. We conducted a pragmatic, pilot study of CYP2C19 genotype-guided pediatric dosing of PPI medications. Children aged 5-17 years old with gastric-acid-related conditions were randomized to receive either conventional dosing of a PPI or genotype-guided dosing for a total of 12 weeks. Sixty children (30 in each arm) were enrolled and had comparable baseline characteristics...
October 20, 2018: Clinical and Translational Science
Jorge Berladi, Pablo M Lamelas
Information of P2Y12 inhibitors in acute coronary syndromes with vein graft angioplasty is limited. This new analysis from the UK database was not able to find significant differences between Clopidogrel, Prasugrel and Ticagrelor. Large trials would be needed to reliably confirm the best antiplatelet regimen in this setting.
October 1, 2018: Catheterization and Cardiovascular Interventions
José Mª Esbrí, Celia Izquierdo, Alba Martínez-Coronado, Iva Miteva, Pablo L Higueras
This manuscript reported data for total suspended particulate matter (TSPM), particle-bound mercury (PBM), and total gaseous mercury (TGM) in Almadenejos, a rural zone of ancient Hg mining and metallurgical works. Concentrations of TSPM characterize the study site as being a rural area, with levels below 40 μg m-3 during most of the year and sporadic events involving dust intrusions from Africa. Mercury speciation of PM and nearby soils, which contain both cinnabar and organic Hg, confirms that the PM comes from local soil emissions involving the soils polluted by ancient metallurgical works...
October 19, 2018: Environmental Science and Pollution Research International
Yoav Hammer, Uri Landes, Oren Zusman, Ran Kornowski, Guy Witberg, Katia Orvin, Amos Levi, Pablo Codner, Hanna Vaknin-Assa, Mithal Nassar, Gideon Shafir, Abid Assali, Ashraf Hamdan
BACKGROUND: Transfemoral Transcatheter Aortic Valve Replacement (TAVR) carries a risk of Vascular Complications (VCs) at the access site. The currently used measures for assessing the risk for VCs are not accurate enough, and sometimes fail to predict them. We therefore aimed to examine whether Iliofemoral artery lumen volume (IFV) assessment with 3-dimensional computed tomography (CT) predicts VCs after transfemoral TAVR. METHODS: We identified 45/560 trans-femoral TAVR patients with VC, then performed nearest neighbor 1:1 matching for patients with no VC, matching for age, sex, TAVR year, valve size and type, closure-device, sheath size and peripheral vascular disease...
October 13, 2018: Journal of Cardiovascular Computed Tomography
Romina Gabriela Armando, Diego Luis Mengual Gómez, Ezequiel Ivan Juritz, Pablo Lorenzano Menna, Daniel Eduardo Gomez
Immortality is one of the main features of cancer cells. Tumor cells have an unlimited replicative potential, principally due to the holoenzyme telomerase. Telomerase is composed mainly by dyskerin (DKC1), a catalytic retrotranscriptase (hTERT) and an RNA template (hTR). The aim of this work is to develop new inhibitors of telomerase, selecting the interaction between hTR⁻DKC1 as a target. We designed two models of the human protein DKC1: homology and ab initio. These models were evaluated by different procedures, revealing that the homology model parameters were the most accurate...
October 18, 2018: International Journal of Molecular Sciences
Javier Vaquero-Martínez, Manuel Antón, José Pablo Ortiz de Galisteo, Roberto Román, Victoria E Cachorro, David Mateos
Integrated water vapor (IWV) data from Global Navigation Satellite Systems (GNSS) and radiosounding (RS) are compared over four sites (Lindenberg, Ny-Ålesund, Lauder and Sodankylä), which are part of the Global Climate Observing System (GCOS) Reference Upper Air Network (GRUAN). Both datasets show an excellent agreement, with a high degree of correlation (R2 over 0.98). Dependences of GNSS-RS differences on several variables are studied in detail. Mean bias error (MBE) and standard deviation (SD) increase with IWV, but in relative term, these variables decrease as IWV increases...
January 15, 2019: Science of the Total Environment
Hamzah Abu-Sbeih, Kati Choi, Cynthia N Tran, Xuemei Wang, Phillip Lum, Gladis Shuttlesworth, John R Stroehlein, Pablo C Okhuysen, Yinghong Wang
BACKGROUND: Cancer patients are susceptible to recurrent Clostridium difficile infection (CDI) that is increasing globally, necessitating new approaches to prevent fatal consequences. We examined the clinical characteristics of cancer patients with recurrent CDI (RCDI). PATIENTS AND METHODS: A retrospective review of cancer patients with C. difficile-positive test between January 2015 and May 2017 was carried out. CDI was defined as diarrhea and toxigenic C. difficile detection in the stool by nucleic acid amplification test and enzyme immunoassay...
October 18, 2018: European Journal of Gastroenterology & Hepatology
Maja Köhn, Yansong Wang, Bernhard Hoermann, Karolina Pavic, Malgorzata Trebaczs, Pablo Rios
PP1-disrupting peptides (PDPs) are selective chemical modulators of protein phosphatase-1 (PP1) that liberate the active PP1 catalytic subunit from regulatory proteins, thus allowing it to dephosphorylate nearby substrates. Here, we optimized the original cell-active PDP3 for enhanced stability, and obtained insights into the chemical requirements for stabilizing this 23mer peptide for cellular applications. The optimized PDP-Nal was used to dissect the involvement of PP1 in the MAPK signaling cascade. Specifically, we demonstrate in human osteosarcoma (U2OS) cells that pMEK1/2 is a direct substrate of PP1, whereas dephosphorylation of pERK1/2 is indirect and likely mediated through enhanced tyrosine phosphatase activity after PDP-mediated PP1 activation...
October 19, 2018: Chembiochem: a European Journal of Chemical Biology
Erika Ramos-Tovar, Laura D Buendia-Montaño, Silvia Galindo-Gómez, Erika Hernández-Aquino, Víctor Tsutsumi, Pablo Muriel
AIM: The aims of the present study were to investigate the capacity of stevia leaves to prevent experimental cirrhosis induced by chronic administration of carbon tetrachloride (CCl4 ) in rats and to explore the action mechanism involved. METHODS: Liver cirrhosis was established by CCl4 administration (400 mg/kg by i.p. 3 times a week for 12 weeks); stevia powder was administered (100 mg/kg by gavage daily) during the CCl4 treatment. Serum markers of liver damage and hydroxyproline were evaluated and histopathological analyses were performed...
October 19, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Sarah Bin Abdulqader, Ziyad Al-Ajlan, Abdulrahman Albakr, Wisam Issawi, Mohammed Al-Bar, Pablo F Recinos, Saad Alsaleh, Abdulrazag Ajlan
PURPOSE: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely limited, and no such reports exist on its utility for pediatric OPGs. Here, we report our results and experience with OPGs treated with the EEA. METHODS: We retrospectively reviewed the medical records of OPG patients who were treated surgically via the EEA at our institutions from 2015 to 2017...
October 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Ireneusz Grulkowski, Silvestre Manzanera, Lukasz Cwiklinski, Juan Mompeán, Alberto de Castro, Jose Maria Marin, Pablo Artal
We demonstrate an optimized optical platform for the three-dimensional (3-D) visualization of crystalline lens opacities in vivo in the eyes of patients with different types and grades of cataracts. We developed a prototype long-depth-range swept source optical coherence tomography (SS-OCT) instrument operating at the speed of 50 kA-scans/second and at the central wavelength of 1 μm to perform high-resolution imaging of the whole anterior segment of the eye. Volumetric data sets of cataractous eyes were acquired and processed to obtain contrast-enhanced high-resolution images of lenticular structures and opacifications...
August 1, 2018: Biomedical Optics Express
Seetha Shankaran, Edward F Bell, Abbot R Laptook, Shampa Saha, Nancy S Newman, S Nadya J Kazzi, John Barks, Barbara J Stoll, Rebecca Bara, Jenna Gabrio, Kirsten Childs, Abhik Das, Rosemary D Higgins, Waldemar A Carlo, Pablo J Sánchez, David P Carlton, Lara Pavageau, William F Malcolm, Carl T D'Angio, Robin K Ohls, Brenda B Poindexter, Gregory M Sokol, Krisa P Van Meurs, Tarah T Colaizy, Ayman Khmour, Karen M Puopolo, Meena Garg, Michele C Walsh
OBJECTIVE: To assess whether length of hospital stay is decreased among moderately preterm infants weaned from incubator to crib at a lower vs higher weight. STUDY DESIGN: This trial was conducted in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants with gestational ages 29-33 weeks, birthweight <1600 g, and in an incubator were randomly assigned to a weaning weight of 1600 or 1800 g. Within 60 to 100 g of weaning weight, the incubator temperature was decreased by 1...
October 15, 2018: Journal of Pediatrics
Antonio Iáñez Domínguez, Raúl Álvarez Pérez, Pablo García-Cubillana de la Cruz, Violeta Luque Ribelles, Elena Morales Marente, María Soledad Palacios Gálvez
The socio-educational groups (GRUSE) are a health and emotional well-being promotion strategy, from an asset-based positive health approach. They principally target women who attend health centres with signs of discomfort with no organic basis finding. The strategy was evaluated through a quasi-experimental longitudinal design, with a mixed methodology. Information was collected from 228 women with a battery of scales and from an analysis of health system databases. Ten in-depth interviews with women were conducted, and 3 discussion groups with professionals...
October 15, 2018: Gaceta Sanitaria
Hugo López-Gatell, Lourdes García-García, Gabriela Echániz-Avilés, Pablo Cruz-Hervert, María Olamendi-Portugal, Deyanira Castañeda-Desales, Miguel Ángel Sanchez-Alemán, Martín Romero-Martínez, Rodrigo DeAntonio, Maria Yolanda Cervantes-Apolinar, Ricardo Cortes-Alcalá, Celia Alpuche-Aranda
To describe hepatitis A virus (HAV) seroprevalence and associated factors in adolescents (10-19 years) and young adults (20-25 years) in different Mexican regions, using 2012 National Health and Nutrition Survey data. A random selection of 1581 serum samples was analyzed. Weighted HAV seroprevalence with 95% confidence intervals (95%CI) and its association with sociodemographic factors were estimated. Mean weighted HAV seroprevalence was 69.3% (95%CI: 64.8-73.4) overall, with 58.8% (95%CI: 53.4-64.1) in adolescents and 83...
October 15, 2018: Vaccine
Pablo Ávila, Francis Bessière, Blandine Mondésert, Sylvia Abadir, Annie Dore, François-Pierre Mongeon, Marc Dubuc, Paul Khairy
OBJECTIVES: The purpose of this study was to assess the safety and efficacy of cryoablation for perinodal substrates in patients with congenital heart disease (CHD) and a displaced atrioventricular (AV) conduction system or an AV conduction system location that was difficult to predict. BACKGROUND: Catheter ablation for perinodal arrhythmias in patients with CHD may incur higher risks due to unconventional or difficult to predict locations of the AV conduction system...
October 2018: JACC. Clinical Electrophysiology
Pablo Piñol, Miguel Martinez-Rach, Pablo Garrido, Otoniel Lopez-Granado, Manuel P Malumbres
Nowadays, more and more vehicles are equipped with communication capabilities, not only providing connectivity with onboard devices, but also with off-board communication infrastructures. From road safety (i.e., multimedia e-call) to infotainment (i.e., video on demand services), there are a lot of applications and services that may be deployed in vehicular networks, where video streaming is the key factor. As it is well known, these networks suffer from high interference levels and low available network resources, and it is a great challenge to deploy video delivery applications which provide good quality video services...
October 17, 2018: Sensors
M José Martin-Piñero, Pablo Ramirez, José Muñoz, M Carmen Alfaro
In the present work aqueous-based emulsions formulated with bio-based solvents and surfactants were studied. The droplet size distribution, rheology and physical stability of rosemary essential oil/water emulsions formulated with an emulsifier derived from wheat waste (alkyl polypentoside) were investigated as a function of the dispersed phase concentration (10-50 wt%) by means of laser diffraction, multiple light scattering and rheology measurements. Subsequently, processing variables, such as the pressure and the number of microfluidization passes, were studied to the best formulation (20 wt% rosemary oil)...
October 10, 2018: Colloids and Surfaces. B, Biointerfaces
Irene Roncero-Ramos, Rosa Jimenez-Lucena, Juan F Alcala-Diaz, Cristina Vals-Delgado, Antonio P Arenas-Larriva, Oriol A Rangel-Zuñiga, Ana Leon-Acuña, María M Malagon, Javier Delgado-Lista, Pablo Perez-Martinez, Jose M Ordovas, Antonio Camargo, Jose Lopez-Miranda
No abstract text is available yet for this article.
September 1, 2018: Journal of Nutritional Biochemistry
Pablo Augusto de Souza Fonseca, Samir Id-Lahoucine, Antonio Reverter, Juan F Medrano, Marina S Fortes, Joaquim Casellas, Filippo Miglior, Luiz Brito, Maria Raquel S Carvalho, Flávio S Schenkel, Loan T Nguyen, Laercio R Porto-Neto, Milton G Thomas, Angela Cánovas
The identification of biological processes related to the regulation of complex traits is a difficult task. Commonly, complex traits are regulated through a multitude of genes contributing each to a small part of the total genetic variance. Additionally, some loci can simultaneously regulate several complex traits, a phenomenon defined as pleiotropy. The lack of understanding on the biological processes responsible for the regulation of these traits results in the decrease of selection efficiency and the selection of undesirable hitchhiking effects...
2018: PloS One
Kevin H Choe, Jared W Coburn, Pablo B Costa, Derek N Pamukoff
Choe, KH, Coburn, JW, Costa, PB, and Pamukoff, DN. Hip and knee kinetics during a back-squat and deadlift. J Strength Cond Res XX(X): 000-000, 2018-The back-squat and deadlift are performed to improve hip and knee extensor function. The purpose of this study was to compare lower extremity joint kinetics (peak net joint moments [NJMs] and positive joint work [PJW]) between the back-squat and deadlift. Twenty-eight resistance-trained subjects (17 men: 23.7 ± 4.3 years, 1.76 ± 0.09 m, 78.11 ± 10.91 kg; 11 women: 23...
October 17, 2018: Journal of Strength and Conditioning Research
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