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Juan José Gagliardino, Jean-Marc Chantelot, Catherine Domenger, Hasan Ilkova, Ambady Ramachandran, Ghaida Kaddaha, Jean Claude Mbanya, Juliana Chan, Pablo Aschner
AIMS: This study aimed to evaluate the impact of diabetes education and access to health care coverage on disease management and outcomes in Latin America. METHODS: Data were obtained from a sub-analysis of 2693 patients with type 1 diabetes mellitus recruited from 9 Latin American countries as part of the International Diabetes Mellitus Practices Study (IDMPS), a multinational, observational survey of diabetes treatment in developing regions. RESULTS: Results from the Latin American cohort show that only 25% of participants met HbA1c target value (<7% [53 mmol/mol])...
August 14, 2018: Diabetes Research and Clinical Practice
Christian Labrador, Andrea Gómez, Geovanny Hernández, Pablo Galindo, Martin Alonso Garzón, Nelson Niño, Enrique Ponce de León, Jorge Ceballos, Adriana Varón, Oscar Beltrán
The symptomatic metastasis of the colon from a pulmonary cancer is rare; however, the global incidence of pulmonary cancer is 12.9%. It is an infrequent site of metastasis, with a prevalence of less than 0.5% in patients with pulmonary cancer. One of the most common manifestation is intestinal obstruction. We present a case report of a patient with an acute lower intestinal bleeding from multiple metastasis lesion of the colon as the initial manifestation of a non-small cell lung carcinoma.
April 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Sebastián Irarrázaval, Pablo Besa, Emmanuel Cauchy, Prativa Pandey, Jorge Vergara
Irarrázaval, Sebastián, Pablo Besa, Emmanuel Cauchy, Prativa Pandey, and Jorge Vergara. Case report of frostbite with delay in evacuation: field use of iloprost might have improved the outcome. High Alt Med Biol 00:000-000, 2018. -Frostbite is a common injury in high altitude medicine. Intravenous vasodilators have a proven efficacy and, recently, have been proposed as a safe outpatient treatment. Nevertheless, the lack of availability and consequently delayed application of this treatment option can result in poor clinical outcomes for patients...
August 17, 2018: High Altitude Medicine & Biology
Yaiza Lopiz, Pablo Checa, Carlos García-Fernández, Jose Valle, Maria Luisa Vega, Fernando Marco
BACKGROUND AND PURPOSE: There is no consensus on the optimal surgical procedure for treating Neer type-2 distal clavicle fractures. Hook plates provide better stability than other fixation methods for small fragments but have been related to multiple complications. METHODS: Retrospective study on patients operated for Neer type-2 fractures using a hook plate. At the time of the study, we performed functional (UCLA and Constant scales) and radiographic (coracoclavicular distance CCD) evaluation and ultrasound assessments of the condition of the rotator cuff...
August 16, 2018: International Orthopaedics
Pablo Nieto, David Müller, Alexander Sheldrick, Alan Günther, Mitsuhiko Miyazaki, Otto Dopfer
The photochemical properties of flavins depend sensitively on their environment and are strongly modified by coordination with metal ions. Herein, the electronic spectra of cold complexes of the smallest flavin molecule (lumichrome, LC, C12N4O2H10) with alkali ions (M+LC, M = Li-Cs) are measured by photodissociation in the visible range (VISPD) in a cryogenic ion trap coupled to a tandem mass spectrometer and an electrospray ionization source. The observed vibronic spectra of all ions are assigned to the optically bright S1 ← S0 (ππ*) transition of the most stable O4 isomer of M+LC by comparison with quantum chemical calculations at the PBE0/cc-pVDZ level coupled to multidimensional Franck-Condon simulations...
August 17, 2018: Physical Chemistry Chemical Physics: PCCP
Zeinab G Khalil, Pablo Cruz-Morales, Cuauhtemoc Licona-Cassani, Esteban Marcellin, Robert J Capon
An inter-kingdom beach warfare between a Streptomyces sp. and Aspergillus sp. co-isolated from shallow water beach sand, collected off Heron Island, Queensland, Australia, saw the bacteriostatic Aspergillus metabolite cyclo-(L-Phe-trans-4-hydroxy-L-Pro) (3) stimulate the Streptomyces to produce nitric oxide (NO), which in turn mediated transcriptional activation of a silent biosynthetic gene cluster (BGC) for fungistatic heronapyrrole B (1). Structure activity relationship studies, coupled with the use of NO synthase inhibitors, donors and scavangers, and both genomic and transcriptomic analyses, confirmed the extraordinary chemical cue specificity of 3, and its NO-mediated mechanism of transcriptional action...
August 16, 2018: ISME Journal
Francisco O'Valle, Juan G de Buitrago, Pedro Hernández-Cortés, Miguel Padial-Molina, Vicente Crespo-Lora, Marien Cobo, David Aguilar, Pablo Galindo-Moreno
This study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after maxillary sinus grafting procedures. Musashi-1 was analyzed by immunohistochemistry and RT-PCR. MSI1 was detected in osteoblasts and osteocytes in 97.4% (38/39) of grafted areas. In native bone, MSI1 was detected in only 66...
August 16, 2018: Scientific Reports
Jubao Duan, Harald H H Göring, Alan R Sanders, Winton Moy, Jessica Freda, Eugene I Drigalenko, Mark Kos, Deli He, Pablo V Gejman
The dopaminergic hypothesis of schizophrenia (SZ) postulates that dopaminergic over activity causes psychosis, a central feature of SZ, based on the observation that blocking dopamine (DA) improves psychotic symptoms. DA is known to have both receptor- and non-receptor-mediated effects, including oxidative mechanisms that lead to apoptosis. The role of DA-mediated oxidative processes in SZ has been little studied. Here, we have used a cell perturbation approach and measured transcriptomic profiles by RNAseq to study the effect of DA exposure on transcription in B-cell transformed lymphoblastoid cell lines (LCLs) from 514 SZ cases and 690 controls...
August 16, 2018: Translational Psychiatry
Clotilde Cadart, Sylvain Monnier, Jacopo Grilli, Pablo J Sáez, Nishit Srivastava, Rafaele Attia, Emmanuel Terriac, Buzz Baum, Marco Cosentino-Lagomarsino, Matthieu Piel
Despite decades of research, how mammalian cell size is controlled remains unclear because of the difficulty of directly measuring growth at the single-cell level. Here we report direct measurements of single-cell volumes over entire cell cycles on various mammalian cell lines and primary human cells. We find that, in a majority of cell types, the volume added across the cell cycle shows little or no correlation to cell birth size, a homeostatic behavior called "adder". This behavior involves modulation of G1 or S-G2 duration and modulation of growth rate...
August 16, 2018: Nature Communications
Petruta Mihaela Matei, Jesús Martín-Gil, Beatrice Michaela Iacomi, Eduardo Pérez-Lebeña, María Teresa Barrio-Arredondo, Pablo Martín-Ramos
Phytophthora cinnamomi , responsible for "root rot" or "dieback" plant disease, causes a significant amount of economic and environmental impact. In this work, the fungicide action of nanocomposites based on silver nanoparticles and polyphenol inclusion compounds, which feature enhanced bioavailability and water solubility, was assayed for the control of this soil-borne water mold. Inclusion compounds were prepared by an aqueous two-phase system separation method through extraction, either in an hydroalcoholic solution with chitosan oligomers (COS) or in a choline chloride:urea:glycerol deep eutectic solvent (DES)...
August 16, 2018: Antibiotics
Iván Montenegro, Alejandro Madrid, Mauricio Cuellar, Michael Seeger, Juan Felipe Alfaro, Ximena Besoain, Juan Pablo Martínez, Ingrid Ramirez, Yusser Olguín, Miryam Valenzuela
Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. tomato , causative agents behind two highly destructive diseases, bacterial canker and bacterial speck, respectively; fungus Fusarium oxysporum f. sp. lycopersici that causes Fusarium Wilt, which strongly affects tomato crops; and finally, Phytophthora spp...
August 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mariana Barturen, Nicolás Abadía, Julián Milano, Pablo A Costanzo Caso, David V Plant
Lately, the integration of two-dimensional materials into semiconductor devices has allowed the modification of their effective index by simply applying a modest voltage (between 0 and 3 volts). In this work, we present a device composed of two evanescently coupled silicon microring resonators where both rings have a graphene layer on top. This design is aimed to produce frequency combs with transmission characteristics controlled upon voltage application to the graphene layer. We numerically analyze the device response as a function of the incident wavelength and applied voltage...
June 11, 2018: Optics Express
Pablo Diaz-Brage, Miguel Fernandez-Del-Olmo, Ling Li, Dan Rio-Rodriguez, Noa Fogelson
We investigated the effect of abstract and real life meaningful images from sports on predictive contextual processing in professional athletes and video gamers. EEG was recorded in three groups: professional basketball players (BP), professional athletes of individual sports (IA) and experienced action video game players (VG). Two recording sessions, each with a different set of visual stimuli was presented: either triangles facing left, up, right or down or four images of a basketball player throwing a ball...
August 13, 2018: Neuroscience Letters
Weien Lai, Haibing Cao, Jun Yang, Guangsheng Deng, Zhiping Yin, Qian Zhang, Beatriz Pelaz, Pablo Del Pino
We present the potential of an antireflection self-reference method based on ultra-thin tantalum nitride (TaN) nanofilms for improving terahertz (THz) reflection spectroscopy. The antireflection self-reference method is proposed to eliminate mutual interference caused by unwanted reflections, which significantly interferes with the important reflection from the actual sample in THz reflection measurement. The antireflection self-reference model was investigated using a wave-impedance matching approach, and the theoretical model was verified in experimental studies...
July 23, 2018: Optics Express
Adam Hirst, Julius Muschaweck, Pablo Benítez
Presented is a quasi-analytic method for irradiance evaluation through a single refractive surface from a single Lambertian source. The method is compared to Monte-Carlo raytracing for a sample system, producing in much less time an irradiance distribution equal to within the latter's statistical noise. In addition to its interest to optical analysis, the method is also useful for optical design problems by allowing for fast, noise-free evaluation of merit functions, along with their derivatives.
July 9, 2018: Optics Express
J Alacia Stainbrook, Amy S Weitlauf, A Pablo Juárez, Julie Lounds Taylor, Jeffrey Hine, Neill Broderick, Amy Nicholson, Zachary Warren
As prevalence of autism spectrum disorder continues to increase, so too does the need for timely, accessible diagnostic consultation. The present work extends from a previous study which provided preliminary evidence for the feasibility of expert clinicians to utilize telemedicine to triage autism spectrum disorder risk in young children. However, it did not examine whether a telediagnostic model had a demonstrable impact on tertiary care center referrals and usage. We therefore examined whether the introduction of telemedicine-based diagnostic consultation for families served by a rural medical facility affected referrals overall as well as to a metropolitan tertiary care diagnostic center...
August 16, 2018: Autism: the International Journal of Research and Practice
Nadia Diovisalvi, Mariana Odriozola, Javier García de Souza, Florencia Rojas Molina, María Soledad Fontanarrosa, Roberto Escaray, José Bustingorry, Pablo Sanzano, Fabian Grosman, Horacio Zagarese
The relationship between the timing of recurrent biological events and seasonal climatic patterns (i.e., phenology) is a crucial ecological process. Changes in phenology are increasingly linked to global climate change. However, current evidence of phenological responses to recent climate change is subjected to substantial regional and seasonal biases. Most available evidence on climate driven phenological changes comes from Northern Hemisphere (NH) ecosystems, and typically involve increases in spring and summer temperatures, which translate into earlier onsets of spring population developments...
August 15, 2018: Global Change Biology
Roberto Walter Israel Olivares, Gabriela Cintia Postma, Andrea Schapira, Dario Ezequiel Iglesias, Laura Beatriz Valdez, Elizabeth Breininger, Pablo Daniel Gazzaneo, Leonardo Minatel
Copper deficiency is an important disease of cattle that produces several clinical signs and lesions, due to alterations in copper-dependent enzymes. One of the organs affected by this deficiency is the heart (falling disease), but nevertheless, these cardiac lesions have not been extensively studied in bovines. The aim of this work was to propose a possible pathogenic mechanism for cardiac lesions in cattle affected by copper deficiency. Because of the possible existence of oxidative distress caused by low levels of copper-zinc-superoxide dismutase and cytochrome oxidase, ultrastructural and histological lesions have been evaluated in the heart of bovines in which a Cu deficiency had been induced using high molybdenum and sulfur levels in the diet...
August 15, 2018: Biological Trace Element Research
Pablo D Nieres, Andrés F Trasarti, Carlos R Apesteguía
Here we present equilibrium data for the cross-metathesis of methyl oleate (MO) with cinnamaldehyde (CA) obtained experimentally from liquid-phase catalytic tests conducted at 323 K. The reaction was carried out in batch reactors, using different reactant molar ratios and the 2nd generation Ru Hoveyda-Grubbs complex as catalyst. Reaction mixtures at the equilibrium were analyzed by gas chromatography. Equilibrium constants were determined by assuming unitary activity coefficients for a cinnamaldehyde/methyl oleate equimolar ratio, and the validity of that approximation was evaluated by calculating the equilibrium conversions for different reactant molar ratios...
October 2018: Data in Brief
Susana Llerena, Nuria García-Díaz, Soraya Curiel-Olmo, Antonio Agraz-Doblas, Agustín García-Blanco, Helena Pisonero, María Varela, Miguel Santibáñez, Carmen Almaraz, Laura Cereceda, Nerea Martínez, María Teresa Arias-Loste, Ángela Puente, Luis Martín-Ramos, Carlos Rodríguez de Lope, Federico Castillo-Suescun, Carmen Cagigas-Fernandez, Pablo Isidro, Carlos Lopez-López, Marcos Lopez-Hoyos, Javier Llorca, Jesús Agüero, Benedicto Crespo-Facorro, Ignacio Varela, Miguel Ángel Piris, Javier Crespo, José Pedro Vaqué
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. There is increasing interest in developing specific markers to serve as predictors of response to sorafenib and to guide targeted therapy. Using a sequencing platform designed to study somatic mutations in a selection of 112 genes (HepatoExome), we aimed to characterize lesions from HCC patients and cell lines, and to use the data to study the biological and mechanistic effects of case-specific targeted therapies used alone or in combination with sorafenib...
July 20, 2018: Oncotarget
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