keyword
https://read.qxmd.com/read/38535471/antioxidant-activity-inhibition-of-intestinal-cancer-cell-growth-and-polyphenolic-compounds-of-the-seagrass-posidonia-oceanica-s-extracts-from-living-plants-and-beach-casts
#21
JOURNAL ARTICLE
Alkistis Kevrekidou, Andreana N Assimopoulou, Varvara Trachana, Dimitrios Stagos, Paraskevi Malea
The aim of the present study was to investigate the use of Posidonia oceanica for making products beneficial for human health. Firstly, we demonstrated that the antioxidant defense (i.e., SOD and APX activity) of P. oceanica 's living leaves (LP) has low efficacy, as they partly neutralize the produced H2 O2 . However, high H2 O2 levels led LP to produce, as a response to oxidative stress, high phenolic content, including chicoric acid, p -coumaric acid, caftaric acid, trans -cinnamic and rutin hydrate, as shown by UHPLC-DAD analysis...
March 11, 2024: Marine Drugs
https://read.qxmd.com/read/38535464/algae-based-supplements-claiming-weight-loss-properties-authenticity-control-and-scientific-based-evidence-on-their-effectiveness
#22
JOURNAL ARTICLE
Fátima Fernandes, Raquel Martins, Mariana Barbosa, Patrícia Valentão
The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements based on algae that claim to aid in weight loss, there is a notable scarcity of scientific evidence supporting their effectiveness, and their regular consumption safety remains inadequately addressed. In this work, commercially available Arthrospira (Spirulina) platensis Gomont and/or Fucus vesiculosus L...
March 5, 2024: Marine Drugs
https://read.qxmd.com/read/38534980/the-assessment-of-sf-36-survey-for-quality-of-life-measurement-after-radical-cystectomy-for-muscle-invasive-bladder-cancer-a-systematic-review
#23
REVIEW
Vlad Barbos, Bogdan Feciche, Silviu Latcu, Alexei Croitor, Vlad Dema, Razvan Bardan, Flaviu Ionut Faur, Tudor Mateescu, Dorin Novacescu, Gherle Bogdan, Alin Adrian Cumpanas
This study presents a systematic review of the literature on individuals' health-related quality of life (HRQoL) following radical cystectomy for muscle-invasive bladder cancer (MIBC), utilizing the Short Form-36 Health Survey (SF-36) as a primary assessment tool. The review was designed as an exhaustive literature search across three major databases including PubMed, Scopus, and Embase up to December 2023, using the PRISMA guidelines. The selection process refined 2281 identified articles down to 11 studies meeting our inclusion criteria...
March 16, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534960/pc-pep-a-comprehensive-daily-six-month-home-based-patient-empowerment-program-leads-to-weight-loss-in-men-with-prostate-cancer-a-secondary-analysis-of-a-clinical-trial
#24
JOURNAL ARTICLE
Wyatt MacNevin, Gabriela Ilie, Ricardo Rendon, Ross Mason, Jesse Spooner, Emily Chedrawe, Nikhilesh Patil, David Bowes, Greg Bailly, David Bell, Derek Wilke, Jeffery B L Zahavich, Cody MacDonald, Robert David Harold Rutledge
Background: The Prostate Cancer-Patient Empowerment Program (PC-PEP) is a six-month daily home-based program shown to improve mental health and urinary function. This secondary analysis explores weight loss in male PC-PEP participants. Methods: In a randomized clinical trial with 128 men undergoing curative prostate cancer (PC) treatment, 66 received 'early' PC-PEP, while 62 were assigned to the 'late' waitlist-control group, receiving 6 months of standard-of-care treatment followed by 6 months of PC-PEP. PC-PEP comprised 182 daily emails with video-based exercise and dietary (predominantly plant-based) education, live online events, and 30 min strength training routines (using body weight and elastic bands)...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534923/the-role-of-adjuvant-radiotherapy-in-the-treatment-of-breast-cancer
#25
REVIEW
Iveta Kolářová, Bohuslav Melichar, Igor Sirák, Jaroslav Vaňásek, Jiří Petera, Kateřina Horáčková, Denisa Pohanková, Filip Ďatelinka, Zuzana Šinkorová, Milan Vošmik
The role of postmastectomy radiotherapy and regional nodal irradiation after radical mastectomy is defined in high-risk patients with locally advanced tumors, positive margins, and unfavorable biology. The benefit of postmastectomy radiotherapy in intermediate-risk patients (T3N0 tumors) remains a matter of controversy. It has been demonstrated that radiotherapy after breast-conserving surgery lowers the locoregional recurrence rate compared with surgery alone and improves the overall survival rate. In patients with four or more positive lymph nodes or extracapsular extension, regional lymph node irradiation is indicated regardless of the surgery type (breast-conserving surgery or mastectomy)...
February 24, 2024: Current Oncology
https://read.qxmd.com/read/38534916/optimization-of-aqueous-extraction-of-polyphenols-from-cuminum-cyminum-seeds-using-response-surface-methodology-and-assessment-of-biological-activity
#26
JOURNAL ARTICLE
Hana El Tannir, Diana Houhou, Espérance Debs, Mohamed Koubaa, Adla Jammoul, Bilal Azakir, Mahmoud I Khalil, Nada El Darra, Nicolas Louka
(1) Background: Cumin seeds, extracted from the plant Cuminum cyminum , are abundant in phenolic compounds and have been extensively researched for their chemical makeup and biological effects. The objective of this research is to enhance the water extraction of polyphenols through the water bath (WB) technique and to evaluate the antiradical, antibacterial, and anticancer effects of the extract. (2) Methods: Response Surface Methodology was used to find the best parameters to extract polyphenols. Three experimental parameters, time, temperature, and solid-liquid ratio, were tested...
March 21, 2024: BioTech (Basel)
https://read.qxmd.com/read/38534837/electrospun-materials-based-on-cellulose-acetate-loaded-with-rosmarinic-acid-with-antioxidant-and-antifungal-properties
#27
JOURNAL ARTICLE
Mariya Spasova, Nikoleta Stoyanova, Olya Stoilova
Fibrous cellulose acetate (CA) materials loaded with rosmarinic acid (RA) were successfully created by one-pot electrospinning. In order to improve the water solubility of the polyphenolic acid and to facilitate its release from the fibrous materials, the non-ionic water-soluble polyethylene glycol (PEG) was added. Detailed characterization of the fabricated fibrous CA/RA and CA/PEG/RA materials was performed using scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), UV-Vis spectroscopy and water contact angle analysis...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534771/prognostic-value-of-p63-expression-in-muscle-invasive-bladder-cancer-and-association-with-molecular-subtypes-preliminary-report
#28
JOURNAL ARTICLE
Francesca Sanguedolce, Ugo Giovanni Falagario, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Stefano Ascani, Simona Tortorella, Gian Maria Busetto, Angelo Cormio, Giuseppe Carrieri, Luigi Cormio
There is an ongoing need for biomarkers that could reliably predict the outcome of BC and that could guide the management of this disease. In this setting, we aimed to explore the prognostic value of the transcription factor P63 in patients with muscle-invasive bladder cancer (MIBC) having undergone radical cystectomy. The correlation between P63 expression and clinicopathological features (tumor stage, nodes involvement, patterns of muscularis propria invasion, papillary architecture, anaplasia, concomitant carcinoma in situ, lymphovascular invasion, perineural invasion, necrosis) and molecular subtyping (basal and luminal type tumors) was tested in 65 radical cystectomy specimens and matched with cancer-specific survival (CSS) and overall survival (OS)...
March 14, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534753/study-on-chemical-composition-and-biological-activity-of-psidium-guajava-leaf-extracts
#29
JOURNAL ARTICLE
Hyonam Park, Bohee Kim, Yuri Kang, Woonjung Kim
Guava ( Psidium guajava ) is a plant widely distributed in tropical and subtropical regions. Its leaves contain a large amount of physiological molecules such as flavonoid, sesquiterpene, triterpenoid, coumarin, alkaloid, and tannin molecules with antioxidative and anti-inflammatory effects. In this study, the use of concentrated P . guajava leaf extract molecules as a functional natural material was evaluated by confirming the extract's antioxidative, antibacterial, tyrosinase activity inhibition, and collagenase activity inhibition effects and its trans-2-nonenal removal ability...
March 6, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534281/chewing-function-with-efficiency-tests-in-subjects-wearing-clear-aligners
#30
JOURNAL ARTICLE
Luca Levrini, Alessandro Deppieri, Andrea Carganico, Giorgia Rodigari, Stefano Saran, Piero Antonio Zecca, Marco Cicciù, Salvatore Bocchieri
This study assessed the masticatory function of participants wearing clear aligners in order to determine whether these devices can be worn even when eating and therefore worn to extend treatment time and boost treatment effectiveness. An intercontrol test was conducted on 20 patients who received Invisalign® treatment. Each participant was instructed to chew two pieces of Hue-Check Gum® chewing gum (one pink and the other blue) in 5, 10, and 20 cycles both with and without aligners. After being removed from the oral cavity, the gum was dried and pressed using a 1 × 50 × 50 mm model that was 3D printed with a transparent layer in between...
March 1, 2024: Dentistry Journal
https://read.qxmd.com/read/38534011/izcp-and-pzcp-redox-non-innocent-cyclopentadienyl-ligands-as-electron-reservoirs-for-sandwich-complexes
#31
JOURNAL ARTICLE
Hyeonjeong Choi, Seunghyuk Yoo, Hayoung Song, Eunsung Lee
A long-sustained effort of systematic steric and electronic modification of cyclopentadienyl (Cp) ligands has enabled them to find wide-ranging, valuable applications. Herein, we present two novel Cp ligands: imidazolium- and pyrrolinium-substituted zwitterionic Cps (IZCp and PZCp), whose key utility is redox non-innocence─the ability to participate cooperatively with the metal center in redox reactions. Through the simple metalation of ZCps, the Cr(0) and Mo(0) half-sandwich complexes (IZCp)Cr(CO)3 , (PZCp)Cr(CO)3 , (IZCp)Mo(CO)3 , and (PZCp)Mo(CO)3 , respectively, as well as the Ru(II) sandwich complexes [(IZCp)RuCp]PF6 and [(PZCp)RuCp]PF6 were prepared...
March 27, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38534000/microwave-coagulation-for-liver-metastases
#32
REVIEW
Dawid Storman, Mateusz J Swierz, Jerzy W Mitus, Michal Pedziwiatr, Ning Liang, Robert Wolff, Malgorzata M Bala
BACKGROUND: Liver metastases (i.e. secondary hepatic malignancies) are significantly more common than primary liver cancer. Long-term survival after radical surgical treatment is approximately 50%. For people in whom resection for cure is not feasible, other treatments must be considered. One treatment option is microwave coagulation utilising electromagnetic waves. It involves placing an electrode into a lesion under ultrasound or computed tomography guidance. OBJECTIVES: To evaluate the beneficial and harmful effects of microwave coagulation versus no intervention, other ablation methods, or systemic treatments in people with liver metastases regardless of the location of the primary tumour...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38533882/resonant-electron-capture-by-polycyclic-aromatic-hydrocarbon-molecules-effects-of-aza-substitution
#33
JOURNAL ARTICLE
Rustem V Khatymov, Mars V Muftakhov, Renat F Tuktarov, Pavel V Shchukin, Lyaysan Z Khatymova, Eugene Pancras, Andrey G Terentyev, Nikolay I Petrov
Resonant electron capture by aza and diaza derivatives of phenanthrene (7,8-benzoquinoline and 1,10-phenanthroline) and anthracene (acridine and phenazine) at incident free electron energies (Ee) in the range of 0-15 eV was studied. All compounds except 7,8-benzoquinoline form long-lived molecular ions (M-) at thermal electron energies (Ee ∼ 0 eV). Acridine and phenazine also form such ions at epithermal electron energies up to Ee = 1.5-2.5 eV. The lifetimes (τa) of M- with respect to electron autodetachment are proportional to the extent of aza-substitution and increase on going from molecules with bent geometry of the fused rings (azaphenanthrenes) to linear isomers (azaanthracenes)...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38533795/improving-magnetic-resonance-imaging-and-chemodynamic-therapy-properties-via-tuning-the-fe-ii-fe-iii-ratio-in-hydrophilic-single-atom-nanobowls
#34
JOURNAL ARTICLE
Qing Luo, Qian Ma, Taoxia Liu, Yiting Luo, Lianying Wang, Chang Guo, Leyu Wang
We developed an intrinsic hydrophilic single-atom iron nanobowl (Fe-SANB) for magnetic resonance imaging (MRI)-guided tumor microenvironment-triggered cancer therapy. Benefiting from the sufficient exposure of Fe single atoms and the intrinsic hydrophilicity of the bowl-shaped structure, the Fe-SANBs exhibited a superior performance for T 1 -weighted MRI with an r 1 value of 11.48 mM-1 s-1 , which is 3-fold higher than that of the commercial Gd-DTPA ( r 1 = 3.72 mM-1 s-1 ). After further coembedding Gd single atoms in the nanobowls, the r 1 value can be greatly improved to 19...
March 27, 2024: ACS Nano
https://read.qxmd.com/read/38533748/stabilization-of-the-neutral-25-hexaphyrin-1-0-1-0-1-0-radical-by-hetero-bimetal-coordination
#35
JOURNAL ARTICLE
Songlin Xue, Yuting Dong, Xiaojuan Lv, Fengxian Qiu, Yue Wang, Hiroyuki Furuta, Toshiharu Teranishi, Fan Wu
Stabilization of hexaphyrin(1.0.1.0.1.0) (named "rosarin") in its 25π radical state is achieved using a hetero-bimetal-coordination strategy. The antiaromatic BF2 complex B-1 was first synthesized, and then rhodium ion was inserted into B-1 to produce the BF2/Rh(CO)2 mixed complex Rh-B-1 as a highly air-stable radical. The structures of B-1 and Rh-B-1 were determined by single-crystal X-ray diffractions, and the antiaromatic or radical character was identified by various spectroscopy evidence and theoretical calculations...
March 27, 2024: Chemistry: a European Journal
https://read.qxmd.com/read/38533621/revolutionizing-eye-care-the-game-changing-applications-of-nano-antioxidants-in-ophthalmology
#36
REVIEW
Yuhang Cheng, Shundong Cai, Han Wu, Jintao Pan, Min Su, Xingyuan Wei, Jinfa Ye, Lang Ke, Gang Liu, Chengchao Chu
Since the theory of free radical-induced aging was proposed in 1956, it has been constantly proven that reactive oxygen species (ROS) produced by oxidative stress play a vital role in the occurrence and progression of eye diseases. However, the inherent limitations of traditional drug therapy hindered the development of ophthalmic disease treatment. In recent years, great achievements have been made in the research of nanomedicine, which promotes the rapid development of safe theranostics in ophthalmology. In this review, we focus on the applications of antioxidant nanomedicine in the treatment of ophthalmology...
March 27, 2024: Nanoscale
https://read.qxmd.com/read/38533558/a-radical-1-4-aryl-migration-enables-nickel-catalysed-remote-cross-electrophile-coupling-of-%C3%AE-bromo-amino-acid-esters-with-vinyl-triflates
#37
JOURNAL ARTICLE
Yin-Ling Liu, Jian Liu, Xin-Yu Li, Peng He, Yu-Xuan Liu, Mei Xiang, Shi Tang
A radical 1,4-aryl migration enabling a cross-electrophile coupling reaction toward remote trans alkylation of N -benzyl alanine has been developed. In this strategy, with the occurrence of a radical-mediated Turce-Smiles rearrangement, key α-aminoalkyl radicals are generated. The as-formed α-aminoalkyl radical serves as a robust coupling partner for cross-electrophilic coupling with vinyl triflates, affording a series of olefin-tethered amino acid motifs.
March 27, 2024: Chemical Communications: Chem Comm
https://read.qxmd.com/read/38533436/a-large-gastric-splenosis-mimicking-gastrointestinal-stromal-tumor-a-case-report-and-literature-review
#38
Xiaotian Li, Xianwen Hu, Pan Wang, Guiyun Hu, Bin Zhou, Jiong Cai
Splenosis pertains to the phenomenon wherein a segment of the spleen undergoes detachment and becomes embedded in other anatomical regions subsequent to traumatic rupture or therapeutic resection, and then progressively establishing blood circulation to foster the regeneration of splenic tissue. Existing literature posits that splenosis predominantly manifests within the confines of the abdominal and pelvic cavities. The objective of the current study was to present an uncommon case involving the occurrence of splenosis within the gastric myometrium, thereby contributing to the current knowledge regarding splenosis...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38533297/ethanol-leaf-extracts-of-anogeissus-leiocarpus-in-antioxidants-and-hepatotoxic-effects-of-escherichia-coli-o157-h7-infected-swiss-mice
#39
JOURNAL ARTICLE
Fred C Akharaiyi, Chioma B Ehis-Eriakha, Peter T Olagbemide, Stephen E Akemu
INTRODUCTION: Diseases caused by bacteria can be managed with medicinal plants with rightful dosage that will not affect body physiology and organs. AIM: This research aimed to evaluate the antioxidants and the effects of Anogeisus leiocarpus on liver function. MATERIALS AND METHODS: Ethanol leaf extracts were processed for antioxidants and hepatotoxic effects using animal models. Group one (negative control) was given access to water and regular feed, group two (positive control) was dosed with 107 CFU/ml of Escherichia coli O157:H7, and groups 3-6 were dosed with 107 E ...
2024: BioMedicine
https://read.qxmd.com/read/38533164/the-effect-of-lymphovascular-invasion-on-short-term-tumor-recurrence-and-progression-in-stage-t1-bladder-cancer
#40
JOURNAL ARTICLE
Osman Gercek, Melih Senkol, Veli Mert Yazar, Kutay Topal
Introduction Lymphovascular invasion (LVI) is the most important stage for tumor spread and metastasis. The role of LVI in transurethral resection is not yet clear. In this study, the progression and recurrences of patients who underwent transurethral resection bladder tumor (TUR-BT) and T1 high-grade tumor and concomitant LVI were detected in pathology results and were evaluated. Methods Our study included 58 patients, who underwent TUR-BT with the suspicion of bladder cancer and were pathologically diagnosed with T1 stage bladder cancer and who did not undergo radical surgery, in the Urology Clinic of Afyonkarahisar Health Sciences University, Turkey...
February 2024: Curēus
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