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https://www.readbyqxmd.com/read/30326429/room-temperature-synthesis-of-oms-2-hybrids-as-highly-efficient-catalysts-for-pollutant-degradation-via-peroxymonosulfate-activation
#1
Peng Ye, Qiancheng Zou, Luyang An, Yi Wei, Aihua Xu, Xiaoxia Li
Due to low cost and low toxicity, manganese oxides have been extensively explored to reduce organic pollutants in wastewater via peroxymonosulfate (PMS) activation; but the development of manganese-based catalysts with facile synthesis process at low temperatures and high efficiency is still of significant practical interest. In this paper, a simple room temperature method has been successfully developed to synthesize cryptomelane-type manganese octahedral molecular sieves (OMS-2) from KMnO4 and MnSO4 in the presence of carbon nanotubes (CNTs)...
October 10, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/30326424/flavin-metamorphosis-cofactor-transformation-through-prenylation
#2
REVIEW
David Leys
Prenylated flavin (prFMN) is a recently discovered cofactor that underpins catalysis in the ubiquitous microbial UbiDX system. UbiX acts as a flavin prenyltransferase while UbiD is a prFMN-dependent reversible (de)carboxylase. The extensive modification of flavin by prenylation, and the consecutive oxidation to the prFMNiminium azomethine ylide, leads to cofactor metamorphosis. While prFMN is no longer able to perform N5-based classical flavin chemistry, it is capable of forming cycloadducts with dipolarophiles, long-lived C4a-based radical species as well as undergoing extensive light driven isomerization...
October 13, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/30326400/%C3%AE-tocopherol-ascorbic-acid-hybrid-antioxidant-based-cationic-amphiphile-for-gene-delivery-design-synthesis-and-transfection
#3
Venkanna Muripiti, Lohchania Brijesh, Hari Krishnareddy Rachamalla, Srujan Kumar Marepally, Rajkumar Banerjee, Srilakshmi V Patri
Natural antioxidants and vitamins have potential to protect biological systems from peroxidative damage induced by peroxyl radicals, α-tocopherol (Vitamin E, lipid soluble) and ascorbic acid (vitamin C, water soluble), well known natural antioxidant molecules. In the present study we described the synthesis and biological evaluation of hybrid of these two natural antioxidants with each other via ammonium di-ethylether linker, Toc-As in gene delivery. Two control cationic lipids N14-As and Toc-NOH are designed in such a way that one is with ascorbic acid moiety and no tocopherol moiety; another is with tocopherol moiety and no ascorbic acid moiety respectively...
April 17, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/30326393/%C3%AE-glutamylcysteine-exhibits-anti-inflammatory-effects-by-increasing-cellular-glutathione-level
#4
Yang Yang, Ling Li, Qiyun Hang, Yuan Fang, Xiaoliang Dong, Peng Cao, Zhimin Yin, Lan Luo
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection and characterized by redox imbalance and severe oxidative stress. Glutathione (GSH) serves several vital functions, including scavenging free radicals and maintaining intracellular redox balance. Extracellular GSH is unable to be taken into the majority of human cells, and the GSH prodrug N-acetyl-l-cysteine (NAC) does not exhibit promising clinical effects. γ-glutamylcysteine (γ-GC), an intermediate dipeptide of the GSH-synthesis pathway and harboring anti-inflammatory properties, represents a relatively unexplored option for sepsis treatment...
September 26, 2018: Redox Biology
https://www.readbyqxmd.com/read/30326277/radical-polymerization-crosslinking-method-for-improving-extracellular-matrix-stability-in-bioprosthetic-heart-valves-with-reduced-potential-for-calcification-and-inflammatory-response
#5
Gaoyang Guo, Linhe Jin, Wanyu Jin, Liang Chen, Yang Lei, Yunbing Wang
In recent years, the number of heart valve replacements has multiplied with valve diseases because of aging populations and the surge in rheumatic heart disease in young people. Among them, bioprosthetic heart valves (BHVs) have become increasingly popular. Transcatheter aortic valve implantation (TAVI) valve as an emerging BHV has been increasingly applied to patients. However, the current commercially used BHVs treated with glutaraldehyde (Glut) still face the problem of durability. BHVs derived from Glut-treated xenogenetic tissues would undergo structural degeneration and calcification sometimes even as short as less than 10 years...
October 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30326226/isolation-molecular-characterization-and-antioxidant-activity-of-a-water-soluble-polysaccharide-extracted-from-the-fruiting-body-of-termitornyces-albuminosus-berk-heim
#6
Yawen Hong, Tiejin Ying
A water-soluble polysaccharide WSP1 was extracted from the fruiting body of Termitornyces albuminosus. Its molecular weight, monosaccharide composition and molecular structure were determined by GPC, GC-MS, UV spectroscopy, FT-IR spectroscopy, methylation analysis, NMR (1D and 2D) and AFM. Moreover, the antioxidant activity of WSP1 was evaluated in vitro by the tests of reducing power, scavenging ability on DPPH radical and hydroxyl radical, and chelating ability on ferrous ion. The results indicated that the molecular weight of WSP1 was 9 kDa, and it was mainly composed of fucose and galactose in a molar ratio of 1:3...
October 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30326031/mechanisms-that-contribute-to-a-profound-reduction-of-the-hiv-1-reservoir-after-allogeneic-stem-cell-transplant
#7
Maria Salgado, Mi Kwon, Cristina Gálvez, Jon Badiola, Monique Nijhuis, Alessandra Bandera, Pascual Balsalobre, Pilar Miralles, Ismael Buño, Carolina Martinez-Laperche, Cristina Vilaplana, Manuel Jurado, Bonaventura Clotet, Annemarie Wensing, Javier Martinez-Picado, Jose Luis Diez-Martin
Background: The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT), including a case of HIV cure, are not fully understood. Objective: To investigate the mechanism of HIV-1 eradication associated with allo-HSCT. Design: Nested case series within the IciStem observational cohort. Setting: Multicenter European study. Participants: 6 HIV-infected, antiretroviral-treated participants who survived more than 2 years after allo-HSCT with CCR5 wild-type donor cells...
October 16, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/30325870/what-is-new-in-robot-assisted-radical-prostatectomy-a-narrative-review
#8
Alberto Martini, Giorgio Gandaglia, Alberto Briganti
PURPOSE OF REVIEW: The implementation of novel technologies and refinements in the surgical technique are continuously changing the urological surgical scenario. The purpose of this review is to provide surgeons with the latest and most relevant updates in the field of robot-assisted radical prostatectomy (RARP) occurred over the last 12 months. RECENT FINDINGS: A randomized-controlled trial showed comparable 24-month urinary continence and erectile function recovery between open radical prostatectomy (ORP) and RARP...
October 15, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/30325613/artificial-sphincter-br-sl-as-904-in-the-treatment-of-urinary-incontinence-after-radical-prostatectomy-efficacy-practicality-and-safety-in-a-prospective-and-multicenter-study
#9
Salvador Vilar Correia Lima, Evandilson Guenes Campos de Barros, Fabio de Oliveira Vilar, Flavia Cristina Morone Pinto, Thomé Décio Pinheiro Barros, José Carlos Truzzi, Luiz Gustavo M de Toledo, Francisco Kanasiro, João Luiz Amaro
PURPOSE: The objective of the present study is to test the efficiency and practicality of a new artificial sphincter "BR - SL - AS - 904" in the control of urinary incontinence in post - PR patients and to evaluate their complications. PATIENTS AND METHODS: Fifteen patients with incontinence after one year of radical prostatectomy were included prospectively. All patients underwent artificial urethral sphincter (AUS) implant "BR - SL - AS - 904" according to established technique...
September 20, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/30325608/safety-and-effectiveness-evaluation-of-open-reanastomosis-for-obliterative-or-recalcitrant-anastomotic-stricture-after-radical-retropubic-prostatectomy
#10
Carlos Roberto Giúdice, Patricio Esteban Lodi, Ana Milena Olivares, Ignacio Pablo Tobia, Gabriel Andrés Favre
PURPOSE: To evaluate safety, efficacy and functional outcomes after open vesicourethral re - anastomosis using different approaches based on previous urinary continence. MATERIALS AND METHODS: Retrospective study of patients treated from 2002 to 2017 due to vesicourethral anastomosis stricture (VUAS) post radical prostatectomy (RP) who failed endoscopic treatment with at least 3 months of follow-up. Continent and incontinent patients post RP were assigned to abdominal (AA) or perineal approach (PA), respectively...
September 20, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/30325603/the-impact-of-single-positive-surgical-margin-features-on-biochemical-recurrence-after-robotic-radical-prostatectomy
#11
Ismail Evren, Ahmet Hacıislamoğlu, Mithat Ekşi, Abdullah Hizir Yavuzsan, Firat Baytekin, Yunus Çolakoğlu, Didem Canoğlu, Volkan Tugcu
OBJECTIVE: Parameters predictive of biochemical or clinical recurrence after Radical Prostatectomy (RP) were determined as pre-treatment PSA value, pathologic tumor stage, tumor grade and presence of Positive Surgical Margin (PSM), extracapsular extension and seminal vesicle invasion and the status of pelvic lymph nodes. The aim of our study is to evaluate the effect of additional features in patients undergoing RP in our clinic. MATERIALS AND METHODS: We studied 556 RP operations performed between 2009 and 2016 for prostate cancer at this clinic...
September 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/30325600/comparison-of-gleason-upgrading-rates-in-transrectal-ultrasound-systematic-random-biopsies-versus-us-mri-fusion-biopsies-for-prostate-cancer
#12
Paulo Priante Kayano, Arie Carneiro, Tiago Mendonça Lopez Castilho, Arjun Sivaraman, Oliver Rojas Claros, Ronaldo Hueb Baroni, Rodrigo Gobbo Garcia, Guilherme Cayres Mariotti, Oren Smaletz, Renne Zon Filippi, Gustavo Caserta Lemos
PURPOSE: Ultrasound-magnetic resonance imaging (US-MRI) fusion biopsy (FB) improves the detection of clinically significant prostate cancer (PCa). We aimed to compare the Gleason upgrading (GU) rates and the concordance of the Gleason scores in the biopsy versus final pathology after surgery in patients who underwent transrectal ultrasound (TRUS) systematic random biopsies (SRB) versus US-MRI FB for PCa. MATERIALS AND METHODS: A retrospective analysis of data that were collected prospectively from January 2011 to June 2016 from patients who underwent prostate biopsy and subsequent radical prostatectomy...
September 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/30325597/predictive-factors-for-prolonged-hospital-stay-after-retropubic-radical-prostatectomy-in-a-high-volume-teaching-center
#13
Rafael F Coelho, Mauricio D Cordeiro, Guilherme P Padovani, Rafael Localli, Limirio Fonseca, José Pontes, Giuliano B Guglielmetti, Miguel Srougi, William Carlos Nahas
OBJECTIVE: To evaluate the length hospital stay and predictors of prolonged hospitalization after RRP performed in a high-surgical volume teaching institution, and analyze the rate of unplanned visits to the office, emergency care, hospital readmissions and perioperative complications rates. MATERIALS AND METHODS: Retrospective analysis of prospectively collected data in a standardized database for patients with localized prostate cancer undergoing RRP in our institution between January/2010 - January/2012...
September 10, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/30325541/radical-cation-initiated-surface-polymerization-on-photothermal-rubber-for-smart-antifouling-coatings
#14
Ruiting Li, Xiaodong Lian, Zhen Wang, Yapei Wang
Biofouling on surfaces of various materials has aroused considerable attentions in biomedical and marine industry. Surface grafting based on covalent surface-initiated polymerization offers a popular route to address this problem by providing diverse robust polymer coatings capable of preventing the biofouling under complex environments. However, the existing methods to synthesize polymer coatings are complicated and rigorous, or require special catalysts, greatly limiting their practical applications. In this work, we report a radical cation-based surface-initiated polymerization protocol to graft the surafce of darkened rubber of trans-polyisoprene (TPI) with thermo-responsive smart polymer, poly(N-isopropylacrylamide) (PNIPAM) via a simple iodine doping process...
October 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30325074/efficient-radical-enhanced-intersystem-crossing-in-ndi-tempo-dyad-photophysical-study-electron-spin-polarization-and-application-in-photodynamic-therapy
#15
Zhijia Wang, Yuting Gao, Mushraf Hussain, Sushma Kundu, Vinayak Rane, Mustafa Hayvali, Elif Akhuseyin Yildiz, Jianzhang Zhao, Halime Gul Yaglioglu, Ranjan Das, Liang Luo, Jianfeng Li
Compact naphthalenediimide (NDI)-2,2,6,6-tetramethyl piperidine N-oxyl (TEMPO) dyad was prepared, with the aim to study the radical-enhanced intersystem crossing (EISC) and the formation of high spin states, as well as the electron spin polarization (ESP) dynamics. Compared to the previously reported radical-chromophore dyads, the present system shows a very high triplet state quantum yield (74%), long-lived triplet state (8.7 microseconds), fast EISC (338 ps) and absorption in the red spectral region. Time-resolved electron paramagnetic resonance (TRERP) spectroscopy shows that, on photoexcitation in fluid solution at room temperature, the D0 state of TEMPO moiety produces strong emissive (E) polarization, owing to the quenching of the excited singlet state of NDI by the radical moiety (electron exchange J > 0)...
October 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30325027/surgery-for-isolated-regional-failure-in-nasopharyngeal-carcinoma-after-radiation-selective-or-comprehensive-neck-dissection
#16
You-Ping Liu, Hao Li, Rui You, Ji-Bin Li, Xue-Kui Liu, An-Kui Yang, Xiang Guo, Ming Song, Quan Zhang, Zhu-Ming Guo, Wen-Kuan Chen, Wei-Wei Liu, Xiong Zou, Yi-Jun Hua, Qi Yang, Yi-Nuan Zhang, Rui Sun, Hao-Yuan Mo, Ling Guo, Ai-Hua Lin, Hai-Qiang Mai, Chao-Nan Qian, Ming-Yuan Chen
OBJECTIVE: To compare survival effects of comprehensive neck dissection (CND) and selective neck dissection (SND) for patients with nasopharyngeal carcinoma (NPC) with only regional failure. METHODS: A total of 294 recurrent T0N1-3M0 NPC patients who underwent neck dissection in Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China, between January 1984 and February 2014, were enrolled in the survival and interaction analyses. Using propensity scores to adjust for potential prognostic factors, an additional well-balanced cohort of 210 patients was constructed by matching each patient who received SND with one patient who underwent CND (1:1); the differences were then compared between SND and CND in terms of overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS)...
October 16, 2018: Laryngoscope
https://www.readbyqxmd.com/read/30324949/four-component-acyloxy-trifluoromethylation-of-arylalkenes-mediated-by-a-photoredox-catalyst
#17
Xiaocong Zhou, Guijie Li, Zongzhou Shao, Kun Fang, Hongjun Gao, Yuanqiang Li, Yuanbin She
A four-component intermolecular trifluoromethylation-acyloxylation of arylalkenes induced by visible light has been developed in the presence of the photoredox catalyst Ru(bpy)3(PF6)2 under mild reaction conditions. A new Umemoto's reagent was used as a trifluoromethyl radical source, and this redox neutral reaction demonstrated good functional group tolerance for aryl alkenes with high yields up to 91%. The detailed reaction process was investigated based on control, deuterium and O18-labeling experiments to support that N,N-dimethylformamide (DMF)/H2O acted as an acyloxyl source...
October 16, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/30324879/radicals-oxidative-nitrosative-stress-and-preeclampsia
#18
Seyithan Taysi, Ayse Saglam Tascan, Mete Gurol Uuro, Mustafa Demir
Oxygen is used by eukaryotic cells for metabolic transformations and energy production in mitochondria. Under physiological conditions, there is a constant endogenous production of free radicals that interact as signaling molecules in physiological mechanisms. Free radicals are neutral molecules, which are produced by separation of ions and molecules. In regular conditions production and disposal of free radicals are at equilibrium. However this equilibrium may not always be experienced, where these species are not eliminated by antioxidants or are excessively produced...
October 15, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/30324833/trimodal-therapy-for-muscle-invasive-bladder-cancer
#19
Joachim Mathes, Steffen Rausch, Tilman Todenhöfer, Arnulf Stenzl
Radical cystectomy is the standard therapy for patients with muscle-invasive bladder cancer. Organ-preserving surgical procedures have been established as alternatives to radical surgery for localized malignancies in other anatomic sites. Trimodal therapy consisting of radiation therapy, chemotherapy, and either transurethral resection of the bladder or partial cystectomy is an effective treatment for selected patients with muscle-invasive bladder cancer that allows for preservation of the urinary bladder. Areas covered: This review provides an overview of the value of trimodal therapy in the treatment of muscle-invasive bladder cancer...
October 16, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/30324783/spermatogenesis-in-testicles-with-germ-cell-tumors
#20
Igal Shpunt, Dan Leibovici, Sergey Ikher, Alexey Kovalyonok, Yuval Avda, Morad Jaber, Abraham Bercovich, Uri Lindner
BACKGROUND: Almost 50% of patients with germ-cell tumors (GCT) are subfertile, and every step of the treatment may further impair fertility. As a result, sperm banking is often advised prior to radical orchiectomy. However, whether affected testes contribute to fertility is unclear. OBJECTIVES: To determine whether maximal tumor diameter (MTD) is correlated with ipsilateral fertility (IF) in patients treated for GCT. METHODS: We reviewed medical charts for demographic and clinical data of patients with GCT who had undergone orchiectomy at our institution between 1999 and 2015...
October 2018: Israel Medical Association Journal: IMAJ
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