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Masahide Fujiki, Mine Ozaki, Yuki Iwashina, Akihiko Takushima
BACKGROUND: Arteriovenous malformation (AVM) is a rare vascular lesion that is difficult to treat. Radical surgical resection followed by free flap transfer is currently one of the preferred treatments, and this study aimed to assess the selection of recipient vessels and clinical outcomes for free flap transfer after AVM resection to establish better surgical management. METHODS: Data from 22 consecutive patients who underwent free flap transfer after AVM resection were retrospectively reviewed...
December 5, 2018: Journal of Plastic Surgery and Hand Surgery
Huaqiang Fan, Peng Pan, Yongqiang Zhang, Wei Wang
A hypervalent iodine(III)-mediated intramolecular decarboxylative Heck-type reaction of 2-vinyl-phenyl oxamic acids has been developed. The unique ring-strain-enabled radical decarboxylation mechanism is preliminarily revealed. This protocol features metal-free reaction conditions and operational simplicity, allowing the lactamization of 2-vinylanilines using a readily accessible carbonyl source and the synthesis of various 2-quinolinones with excellent chemoselectivity at room temperature.
December 5, 2018: Organic Letters
Jiří Tuček, Katerina Hola, Giorgio Zoppellaro, Piotr Blonski, Rostislav Langer, Miroslav Medved, Toma Susi, Michal Otyepka, Radek Zbořil
Stabilization of ferromagnetic ordering in graphene-based systems up to room temperature remains an important challenge owing to huge scope for applications in electronics, spintronics, biomedicine, and separation technologies. To date, several strategies have been proposed, including edge engineering, introduction of defects and dopants, and covalent functionalization. However, these techniques are usually hampered by limited temperature sustainability of ferromagnetic ordering. Here, we describe a method for the well-controlled sp3 functionalization of graphene to synthesize zig-zag conjugated sp2 carbon chains that can act as communication pathways among radical motifs...
December 5, 2018: ACS Nano
A J Stasyuk, O A Stasyuk, Miquel Solà, A A Voityuk
Porphyrin-fullerene dyads are promising candidates for organic photovoltaic devices. Electron transfer (ET) properties of the molecular devices depend significantly on the mutual position of the donor and acceptor. Recently, a new type of molecular isomerism (akamptisomerism) has been discovered. In the present study, we explore how photoinduced ET can be modulated by passing from one akamptisomer to another. To this aim, four akamptisomers of quinoxalinoporphyrin-[60]fullerene complex are selected for the computational study...
December 5, 2018: Chemistry: a European Journal
Lee Smith, Jung Ae Lee, Junbae Mun, Ratna Pakpahan, Kellie R Imm, Sonya Izadi, Adam S Kibel, Graham A Colditz, Robert L Grubb Iii, Kathleen Y Wolin, Siobhan Sutcliffe, Lin Yang
BACKGROUND: No prior study has measured or compared self-reported and objectively measured physical activity trajectories in prostate cancer survivors before and after treatment. METHODS: Clinically localized prostate cancer patients treated with radical prostatectomy were recruited between 2011 and 2014. Of the 350 participants enrolled at the main site, 310 provided self-reported physical activity at baseline before radical prostatectomy, and 5 weeks, 6 months, and 12 months after radical prostatectomy...
December 5, 2018: Cancer
Rensi Marco, Ferretti Guido, Di Gregorio Fernando, Evangelista Laura
A 73-year-old man with a prostate cancer treated by radical prostatectomy in 2006. For a biochemical recurrence of disease (prostate-specific antigen level, 0.1 ng/mL) during hormonal therapy, patient underwent F-choline PET/CT that showed a significant uptake in a diffuse right pleural thickening. The patient was sent to pleurectomy decortication showing an epithelioid pleural mesothelioma. This case highlighted that a histopathological evaluation is mandatory in case of a significant radiolabeled choline uptake in pleural lesions...
December 3, 2018: Clinical Nuclear Medicine
Varsha I Shah, Gareth L Rowlands, Ian W Thompson, Vaiyapuri P Sumathi, W Glenn McCluggage
Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Immunohistochemically, the tumor cells were diffusely positive for CD31, CD34, ERG, and cyclin D1 and focally positive for D2-40...
December 3, 2018: International Journal of Gynecological Pathology
G Kvaratskhelia, E Tikaradze, M Buleishvili, G Sharashenidze, G Ormotsadze, Т Sanikidze
The purpose of our study was to identify the nature of the cause-effect relationship between the risks of developing of Chronic Obstructive Pulmonary Disease (COPD) and Cardio-vascular Disease (CVD) in patients residing in the villages of Chiatura district, characterized by varying degrees of environmental stress. The residents (n=400) of the Chiatura district living in the villages, Khreiti, Perevisa and Rgani were examined. The villages are characterized by different degrees of ecological tension (the villages differ both in their remoteness from sources of environmental pollution - manganese mining quarries and the scale of its extraction, which allows them to rank according to the degree of environmental tension: Khreiti - low, Perevis - medium, Rgani - high)...
October 2018: Georgian Medical News
Seracetttin Eğin, Ali Alemdar, Fazıl Sağlam, Burak Güney, Hakan Güven
Presently described is a case treated via stent and vacuum-assisted closure (VAC). The patient developed an oesophagojejunostomy leak (OL) on the ninth postoperative day after a radical total gastrectomy. The patient was a 55-year-old male patient with adenocarcinoma localized to the small curvature on the corpus of the stomach. Relaparatomy was performed for the OL, including placement of an uncovered stent. The abdomen was washed 4 times. As the OL did not decrease, 2 covered stents (22 mm and 18 mm in diameter and 80 mm long) were inserted endoscopically...
November 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Yu Wang, Hongjing Zhao, Menghao Guo, Yizhi Shao, Juanjuan Liu, Guangshun Jiang, Mingwei Xing
The kidney is the most crucial site for the excretion of arsenic and its metabolites. In this study, Hy-line chickens exposed to different toxicologically relevant doses of arsenic (0, 7.5, 15 and 30 mg kg-1 diet) presented marked renal injury as evidenced by the increased leakage of blood urea nitrogen (up to 2.6 folds) and creatinine (up to 2.3 folds). Furthermore, increased content of renal arsenic (up to 30 folds) and malondialdehyde restrained anti-hydroxyl radical ability, and the activities of antioxidant enzymes (glutathione peroxidase, catalase) further corroborated extensive renal damage...
December 5, 2018: Metallomics: Integrated Biometal Science
Valentina Vignali, Barbara S Miranda, Irene Lodoso-Torrecilla, Cathelijn A J van Nisselroy, Bas-Jan Hoogenberg, Sybren Dantuma, Frank Hollmann, Jan Willem de Vries, Eliza M Warszawik, Rainer Fischer, Ulrich Commandeur, Patrick van Rijn
Engineered viruses are finding an increasing number of applications in basic, translational research and materials science. Genetic and chemical engineering of capsids represents a key point for tailoring the properties of viral particles, but the synthetic efforts and limits accompanying these processes still hinder their usability. Here, a single-step highly selective biocatalytic functionalization approach is described, providing a general platform for virus-acrylate hybrid particles. The tobacco mosaic virus (TMV) and the bacteriophage M13 have been successfully modified via laccase induced free radical formation on the tyrosine residues through single electron oxidation as the initiating step and the free radicals subsequently react with acrylate-based monomers...
December 5, 2018: Chemical Communications: Chem Comm
Jomana Al-Nu'airat, Bogdan Z Dlugogorski, Xiangpeng Gao, Nassim Zeinali, Jakub Skut, Phillip R Westmoreland, Ibukun Oluwoye, Mohammednoor Altarawneh
Photo-degradation of organic pollutants plays an important role in their removal from the environment. This study provides an experimental and theoretical account of the reaction of singlet oxygen O2(1Δg) with the biodegradable-resistant species of phenol in an aqueous medium. The experiments combine customised LED-photoreactors, high-performance liquid chromatography (HPLC), and electron paramagnetic resonance (EPR) imaging, employing rose bengal as a sensitiser. Guided by density functional theory (DFT) calculations at the M062X level, we report the mechanism of the reaction and its kinetic model...
December 5, 2018: Physical Chemistry Chemical Physics: PCCP
Hejun An, Shaoyu Mai, Qingqing Xuan, Yao Zhou, Qiuling Song
An expedient strategy for the synthesis of 5-oxazole ketones was developed via homogeneous gold catalysis with 4-MeO-TEMPO as an oxidant. The desired 5-oxazole ketones were achieved in decent yields with excellent functional group compatibility under mild conditions. The current protocol also represents the first example for merging gold catalyst and radical chemistry in one-pot synthesis with internal N-propargylamides.
December 5, 2018: Journal of Organic Chemistry
Peihong Xue, Wendong Liu, Zhongyi Gu, Xingchi Chen, Jingjie Nan, Junhu Zhang, Hongchen Sun, Zhanchen Cui, Bai Yang
Gradient biomaterials have shown enormous potential in high-throughput screening of biomaterials and material-induced cell migration. To make the screening process more rapid and precise, improving the regularity of morphological structure and chemical modification on gradient biomaterials have attract much attention. In this paper, we present a novel fabrication strategy to introduce ordered nanopattern arrays into gradient biomaterials, through combining surface-initiated atom transfer radical polymerization (SI-ATRP) and inclined reactive ion etching (RIE) based on colloidal lithography...
December 5, 2018: ACS Applied Materials & Interfaces
Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Free radicals generated via irradiation with UV-light of a frozen solution containing a fraction of pyruvic acid (PA), have demonstrated their dissolution Dynamic Nuclear Polarization (dDNP) potential providing up to 30% [1-13C]PA liquid-state polarization. Moreover, their labile nature has proven to pave a way to nuclear polarization storage and transport. Herein, differently from the case of PA, we tackled the issue of providing dDNP UV-radical precursors, trimethylpyruvic acid (TriPA) and its methyl-deuterated form d9-TriPA, not involved in any metabolic pathway...
December 4, 2018: Angewandte Chemie
Angela T S Wyse, Mateus Grings, Moacir Wajner, Guilhian Leipnitz
Sulfite oxidase (SO) deficiency is an autosomal recessive inherited neurometabolic disease caused by deficient activity of SO. It is biochemically characterized by tissue accumulation and high urinary excretion of sulfite, thiosulfate, and S-sulfocysteine. Severe neurological symptoms, including neonatal seizures, encephalopathy, and psychomotor retardation, are commonly observed in the affected patients, but the pathogenesis of the neurologic dysfunction is still poorly understood. In this minireview, we will briefly summarize the knowledge obtained from in vivo and in vitro findings from animal studies indicating that oxidative stress and mitochondrial dysfunction are involved in the pathophysiology of the brain damage in this disease...
December 5, 2018: Neurotoxicity Research
Ping Feng Lim, Kah Hon Leong, Lan Ching Sim, Azrina Abd Aziz, Pichiah Saravanan
In this work, a sunlight-sensitive photocatalyst of nanocubic-like titanium dioxide (TiO2 ) and N-doped graphene quantum dots (N-GQDs) is developed through a simple hydrothermal and physical mixing method. The successful amalgamation composite photocatalyst characteristics were comprehensively scrutinized through various physical and chemical analyses. A complete removal of bisphenol A (BPA) is attained by a synthesized composite after 30 min of sunlight irradiation as compared to pure TiO2 . This clearly proved the unique contribution of N-GQDs that enhanced the ability of light harvesting especially under visible light and near-infrared region...
December 4, 2018: Environmental Science and Pollution Research International
Alok Kumar Tripathi, Sushma Kundu, Ranjan Das
Charge-transfer (CT) electronic states are generally seen in molecules involving interactions between species of low ionization potential and high electron affinity. In this context, the 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) free radical is not considered to be a typical molecule to form charge transfer states with aromatic hydrocarbons. Nevertheless, involvement of such CT states has been invoked in rationalising the spin-dependent photophysical quenching of excited states of aromatic systems by TEMPO during bimolecular collisions...
December 5, 2018: Physical Chemistry Chemical Physics: PCCP
Hee-Jeong Kim, Bohkyung Kim, Eun-Gyung Mun, Soon-Yeon Jeong, Youn-Soo Cha
BACKGROUND/OBJECTIVES: Ginger, a root vegetable, is known to have antioxidant and antiobesity effects. Preparation, such as by steaming, can affect the chemical composition of prepared root vegetables or herbs and can change their functional activities. In the present study, we investigated the protective effects of steamed ginger against oxidative stress and steatosis in C57BL/6J mice fed a high-fat diet. MATERIALS/METHODS: The levels of polyphenols and flavonoids in two different extracts of steamed ginger, i...
December 2018: Nutrition Research and Practice
You-Suk Lee, Il Je Cho, Joo Wan Kim, Sun-Kyoung Lee, Sae Kwang Ku, Hae-Jeung Lee
BACKGROUND/OBJECTIVES: The honeysuckle berry (HB) contains ascorbic acid and phenolic components, especially anthocyanins, flavonoids, and low-molecular-weight phenolic acids. In order to examine the potential of HB as a hepatoprotective medicinal food, we evaluated the in vitro anti-oxidant and anti-inflammatory activities of Korean HB (HBK) and Chinese HB (HBC). MATERIALS/METHODS: Antioxidant and anti-inflammatory effects of the extracts were examined in HepG2 and RAW 264...
December 2018: Nutrition Research and Practice
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