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Bardia Bidarmaghz, Roderick Cyril Borrowdale, Kasra Raufian
BACKGROUND: Femoral hernia accounts for 3% of all the hernias, and in 0.5-5% of cases, the appendix can migrate through the femoral hernia and is called de Garengeot hernia. It is a very rare condition, and the incidence of appendicitis in this type of hernia is as low as 0.08-0.13%. CASE PRESENTATION: We bring into discussion a case of a 47-year-old female who presented to the emergency department with a painful right-sided groin lump for the past 2 days. After initial resuscitation, a CT scan was requested which showed the presence of inflamed appendix inside the femoral canal...
December 13, 2018: Surgical Case Reports
Eun Young Chae, Hak Hee Kim, Ji-Wook Jeong, Seung-Hoon Chae, Sooyeul Lee, Young-Wook Choi
OBJECTIVES: To compare the diagnostic performance and interpretation time of digital breast tomosynthesis (DBT) for both novice and experienced readers with and without using a computer-aided detection (CAD) system for concurrent read. METHODS: CAD system was developed for concurrent read in DBT interpretation. In this observer performance study, we used an enriched sample of 100 DBT cases including 70 with and 30 without breast cancers. Image interpretation was performed by four radiologists with different experience levels (two experienced and two novice)...
December 13, 2018: European Radiology
Nikhil Adapa, Nikhil Jain, Allison Capek, Rajiv Chandawarkar, Safdar N Khan, Yazeed M Gussous, Elizabeth Yu
Background: Wound complications can occur in up to 20% of patients following multilevel posterior spinal fusion. Currently, the use of local flaps has been reported in high-risk patients with a history of spinal neoplasm, radiation therapy, exposed hardware, multiple spine surgeries, or wound infections. However, there are no reports of prophylactic muscle flap wound closure in patients undergoing multi-level spinal fusion for degenerative pathology. Given the extensive soft tissue dissection for exposure compounded by patient comorbidities, there is potential to minimize the risk of wound complications with prophylactic trapezius and/or paraspinal flap coverage...
September 2018: Journal of Spine Surgery (Hong Kong)
Hui Lin, Xiaoyang Du, Lijuan Li, Caijun Zheng, Silu Tao
A novel pyrene-imidazole derivative (PyPI), which can form effcient π-π stacking in solid film, has been utilized in organic solar cells (OSCs). The stacking of small a molecule PyPI can facilitate a charge transfer and suppress fullerene aggregation. As a result, PTB7-Th: PyPI: PC71 BM based ternary OSC exhibits a high power conversion efficiency (PCE) of 10.36%, which presents a 15.88% increase from the binary device (8.94%). Concurrently, the ternary OSC shows a much better thermal and light illumination stability...
2018: Frontiers in Chemistry
Khaled Farouk, Thoas Shipley, Tarek El-Bialy
OBJECTIVES: To evaluate the possible change in teeth lengths as an indicator of orthodontically induced tooth root resorption (OITRR) after high-frequency mechanical vibration (HFV) treatment concurrent with Invisalign Smart Track® aligners as evaluated by cone beam computed tomography (CBCT). MATERIALS AND METHODS: The sample, composed of 30 patients with an average age of 26 ± 11 years and Class I malocclusion with an initial anterior crowding ranging from 3 to 5 mm, was divided equally into two groups; Group I received adjunctive high-frequency mechanical vibration (HFV); Group II, the control, did not receive adjunctive mechanical treatment...
2018: Journal of Orthodontic Science
Bing Yan, Meiqi Cui, Junhao You, Fang Li, Hui Liu
Gastric adenocarcinoma concurrent with metastatic neuroendocrine cancer (NEC) is rare. In the present case report, a 39-year-old male was first pathologically diagnosed by gastric endoscopy as having a highly differentiated adenocarcinoma. Next, positron emission tomography-computed tomography examination and bone marrow biopsy confirmed extensive metastasis. Subsequently, the patient underwent 6 cycles of immunotherapy (nivolumab, 160 mg) and 5 cycles of chemotherapy based on the XELOX regimen (oxaliplatin + capecitabine)...
December 2018: Molecular and Clinical Oncology
Kota Nishihama, Noriko Furuta, Kanako Maki, Yuko Okano, Rei Hashimoto, Yasuhiro Hotta, Mei Uemura, Taro Yasuma, Toshinari Suzuki, Corina N D'Alessandro-Gabazza, Yutaka Yano, Esteban C Gabazza
A 47-year-old woman with diabetes treated with high-dose insulin was admitted to Mie University Hospital, Tsu, Japan, for screening of secondary diabetes mellitus and obesity. Laboratory tests and imaging studies were consistent with Cushing's disease (CD). The patient underwent trans-sphenoidal pituitary surgery. The patient exhibited loss of body weight (85.9 to 80.0 kg), improved glycated hemoglobin (HbA1c) (11.2 to 7.8%) and required lower doses of insulin (112 to 46 U/day) 6 months after surgery. The patient's body weight and daily insulin dose remained stable during the following 5 months (6-11 months after surgery)...
December 2018: Biomedical Reports
Narushi Sugii, Hiroyuki Fujimori, Naoaki Sato, Akira Matsumura
Objective: This study aimed to evaluate the regular medications prescribed to elderly neurosurgical inpatients in community hospitals in Japan. Materials and Methods: Elderly patients (aged ≥ 65 years) who had been admitted to neurosurgery departments from April 2015 to March 2017 were enrolled in this study. We collected data on regular medications at the time of admission and discharge. Furthermore, we retrospectively analyzed factors associated with potentially inappropriate medications (PIMs). PIMs were defined as polypharmacy (≥ 6 medications used concurrently) or taking any of the unfavorable medications on the "list of drugs to be prescribed with special caution" in the "Guidelines for Medical Treatment and Its Safety in the Elderly 2015"...
November 2018: Journal of Rural Medicine: JRM
Chao Han, Lanzhu Gao, Han Bai, Xiaoguang Dou
Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. However, to the best of our knowledge, the diagnostic value of AKR1B10 in early stage HCC is poorly understood. In the current study, the diagnostic performance of serum AKR1B10 in hepatitis B virus/hepatitis C virus (HBV/HCV)-related liver disorders was evaluated and the unique role of AKR1B10 in diagnosing HCC was assessed...
December 2018: Oncology Letters
Taicheng Zhou, Lili Wu, Qirui Wang, Zhipeng Jiang, Yingru Li, Ning Ma, Wenhao Chen, Zehui Hou, Wenchang Gan, Shuang Chen
Colorectal cancer (CRC) is a malignancy with high metastatic rates. The mechanism of miR-128 on the regulation of Ribophorin-II (RPN2) in CRC cells was explored in the present study. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) or western blot analyses were conducted to detect miR-128 and RPN2 levels in tissues and cell lines. AmiR-128 overexpression model was constructed using miR-128 mimic transfection in HT29 CRC cells. Then, cell proliferation was detected using a Cell Counting Kit-8 assay, and the migratory and invasive abilities were measured by Transwell assay...
December 2018: Oncology Letters
S W Davis, C A Crowell, L Beynel, L Deng, D Lakhlani, S A Hilbig, W Lim, D Nguyen, A V Peterchev, B M Luber, S H Lisanby, L G Appelbaum, R Cabeza
Working memory (WM) is assumed to consist of a process that sustains memory representations in an active state (maintenance) and a process that operates on these activated representations (manipulation). We examined evidence for two distinct, concurrent cognitive functions supporting maintenance and manipulation abilities by testing brain activity as participants performed a WM alphabetization task. Maintenance was investigated by varying the number of letters held in WM and manipulation by varying the number of moves required to sort the list alphabetically...
December 13, 2018: Scientific Reports
Peng Sun, Charles Chubb, Charles E Wright, George Sperling
Grouping is a perceptual process in which a subset of stimulus components (a group) is selected for a subsequent-typically implicit-perceptual computation. Grouping is a critical precursor to segmenting objects from the background and ultimately to object recognition. Here, we study grouping by color. We present subjects with 300-ms exposures of 12 dots colored with the same but unknown identical color interspersed among 14 dots of seven different colors. To indicate grouping, subjects point-click the remembered centroid ("center of gravity") of the set of homogeneous dots, of heterogeneous dots, or of all dots...
December 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Yoshihisa Nakamura, Motohiko Suzuki, Shinya Ozaki, Makoto Yokota, Meiho Nakayama, Hideo Hattori, Hiroshi Inagaki, Shingo Murakami
We report a rare case of sinonasal inverted papilloma (IP) associated with small cell neuroendocrine carcinoma (SNEC). To our knowledge, this is the first report to describe SNEC found during the treatment of sinonasal IP. Surgery and five cycles of cisplatin plus etoposide with concurrent intensity modulated radiation therapy were performed. Neither local recurrence nor distant metastasis was noted during 6 years of post-diagnostic follow-up. The prognosis of SNEC is very poor. Treatment planning for sinonasal IP should consider a possible association with this rare but aggressive malignancy, whose treatment is completely different from that of squamous cell carcinoma, a malignancy which is commonly associated with IP...
December 10, 2018: Auris, Nasus, Larynx
Pavel Overtchouk, Jean-Philippe Collet
TAVI is currently recommended for severe symptomatic aortic stenosis in patients at prohibitive, high or intermediate surgical risk as estimated by surgical risk scores (STS score and EuroSCORE II). Comorbidity, technical feasibility of TAVI and concurrent pathology with need for complementary surgical correction are conditions to be considered to choose between open surgery and TAVI. The decision is often made by the "Heart Team". The transfemoral access must be favored. Conduction disturbance, stroke, bioprosthesis thrombosis and durability are the main setbacks of TAVI...
December 10, 2018: La Presse Médicale
Kalysha Closson, Alexis Palmer, Kate Salters, Cathy Puskas, Surita Parashar, Lateefa Tiamiyu, Wendy Zhang, Rolando Barrios, Angela Kaida, Robert S Hogg
PURPOSE: We assessed differences in optimal adherence between youth (aged 15-29 years) and adults (aged ≥30 years) enrolled in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program from 2010 to 2016. METHODS: Population-level clinical data were used to compare optimal antiretroviral therapy adherence (≥95%), based on pharmacy refill data, among youth and adults. Unadjusted and adjusted generalized estimating estimates were performed to examine the independent relationship between time-dependent age categories and optimal adherence, adjusting for confounders...
November 28, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Thiago Ferreira de Toledo, Huei Diana Lee, Newton Spolaôr, Cláudio Saddy Rodrigues Coy, Feng Chung Wu
The overall purpose of automatic speech recognition systems is to make possible the interaction between humans and electronic devices through speech. For example, the content captured from user's speech using a microphone can be transcribed into text. In general, such systems should be able to overcome adversities such as noise, communication channel variability, speaker's age and accent, speech speed, concurrent speeches from other speakers and spontaneous speech. Despite this challenging scenario, this study aims to develop a Web System Prototype to generate medical reports through automatic speech recognition in the Brazilian Portuguese language...
January 2019: International Journal of Medical Informatics
Henry E Wang, John P Donnelly, Sachin Yende, Emily B Levitan, Nathan I Shapiro, Yuling Dai, Hong Zhao, Gerardo Heiss, Michelle Odden, Anne Newman, Monika Safford
There are no validated systems for characterizing long-term risk of severe sepsis in community-dwelling adults. We tested the ability of the REasons for Geographic and Racial Differences in Stroke-Severe Sepsis Risk Score (REGARDS-SSRS) to predict 10-year severe sepsis risk in separate cohorts of community-dwelling adults. We internally tested the REGARDS-SSRS on the REGARDS-Medicare subcohort. We then externally validated the REGARDS-SSRS using (1) the Cardiovascular Health Study (CHS) and (2) the Atherosclerosis Risk in Communities (ARIC) cohorts...
December 11, 2018: Journal of Clinical Medicine
Gyu Sang Yoo, Dongryul Oh, Hongryull Pyo, Yong Chan Ahn, Jae Myung Noh, Hee Chul Park, Do Hoon Lim
We performed a retrospective analysis to evaluate treatment outcomes and the risk of fatal hemorrhage by tumor regression when definitive concurrent chemo-radiotherapy (CCRT) was delivered to patients with non-small cell lung cancer (NSCLC) invading adjacent great vessels on radiological findings. We selected 37 unresectable NSCLC patients with adjacent great vessel invasion (GVI) by carefully reviewing each patient's images. The criteria of definite GVI were as follows: irregular indentation at the tumor-vessel contact border, slit-like narrowing of adjacent great vessels by the tumor, presence of intra-luminal mass formation, tumors contacting >5 cm of adjacent great vessel and obliteration of the intervening fat plane between tumor and adjacent great vessel, and/or tumors contacting more than half of the circumference of the aortic wall...
December 13, 2018: Journal of Radiation Research
Jillian M Haines
Megaesophagus affects dogs worldwide but limited information is available regarding its characteristics in the general population of dogs. The objectives of this study were to provide information on a large population of dogs diagnosed with megaesophagus in regards to population characteristics, medical and family history, diagnosis, concurrent disease, and predisposing factors. A link to a web-based survey was provided on megaesophagus support websites and 838 eligible surveys were evaluated. Breeds most frequently associated with congenital megaesophagus were German shepherds, mixed breed "goldendoodles", Labrador retrievers, great Danes, and dachshunds...
November 30, 2018: Research in Veterinary Science
Breanne Hobden, Jamie Bryant, Kristy Forshaw, Christopher Oldmeadow, Tiffany-Jane Evans, Rob Sanson-Fisher
Objectives This study sought to determine, among a large sample of Australian general practice patients: (1) the prevalence of smoking among different levels of alcohol misuse; and (2) whether the associations between demographic characteristics and alcohol use differ according to smoking status. Methods A cross-sectional survey was administered from 2010 to 2011 to 3559 patients from 12 Australian urban general practices. Patients reported their demographic details, smoking status and their alcohol intake...
December 14, 2018: Australian Health Review: a Publication of the Australian Hospital Association
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