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https://www.readbyqxmd.com/read/30120901/psychosocial-outcomes-in-cancer-bereaved-children-and-adolescents-a-systematic-review
#1
REVIEW
Rahel Hoffmann, Julia Kaiser, Anette Kersting
OBJECTIVE: Due to the unique importance of parental and sibling relationships and concurrently existing developmental challenges, the loss of a parent or sibling due to cancer is a highly stressful event for children and adolescents. This is the first systematic review that integrates findings on psychosocial outcomes after parental or sibling cancer bereavement. METHODS: A systematic search of Web of Science, PubMed, PsycINFO, and PubPsych was conducted, last in December 2017...
August 18, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/30120800/blastema-formation-and-periosteal-ossification-in-the-regenerating-adult-mouse-digit
#2
Lindsay A Dawson, Paula P Schanes, Patrick Kim, Felisha M Imholt, Osama Qureshi, Connor P Dolan, Ling Yu, Mingquan Yan, Katherine N Zimmel, Alyssa R Falck, Ken Muneoka
While mammals cannot regenerate amputated limbs, mice and humans have regenerative ability restricted to amputations transecting the digit tip, including the terminal phalanx (P3). In mice the regeneration process is epimorphic and mediated by the formation of a blastema comprised of undifferentiated proliferating cells that differentiate to regenerate the amputated structures. Blastema formation distinguishes the regenerative response from a scar-forming healing response. The mouse digit tip serves as a pre-clinical model to investigate mammalian blastema formation and endogenous regenerative capabilities...
August 18, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/30120548/tree-growth-and-water-use-in-hyper-arid-acacia-occurs-during-the-hottest-and-driest-season
#3
Gidon Winters, Dennis Otieno, Shabtai Cohen, Christina Bogner, Gideon Ragowloski, Indira Paudel, Tamir Klein
Drought-induced tree mortality has been recently increasing and is expected to increase further under warming climate. Conversely, tree species that survive under arid conditions might provide vital information on successful drought resistance strategies. Although Acacia (Vachellia) species dominate many of the globe's deserts, little is known about their growth dynamics and water-use in situ. Stem diameter dynamics, leaf phenology, and sap flow were monitored during 3 consecutive years in five Acacia raddiana trees and five Acacia tortilis trees in the Arid Arava Valley, southern Israel (annual precipitation 20-70 mm, restricted to October-May)...
August 18, 2018: Oecologia
https://www.readbyqxmd.com/read/30120303/humpback-whale-migrations-to-antarctic-summer-foraging-grounds-through-the-southwest-pacific-ocean
#4
V Andrews-Goff, S Bestley, N J Gales, S M Laverick, D Paton, A M Polanowski, N T Schmitt, M C Double
Humpback whale (Megaptera novaeangliae) populations typically undertake seasonal migrations, spending winters in low latitude breeding grounds and summers foraging in high latitude feeding grounds. Until recently, a broad scale understanding of whale movement has been derived from whaling records, Discovery marks, photo identification and genetic analyses. However, with advances in satellite tagging technology and concurrent development of analytical methodologies we can now detail finer scale humpback whale movement, infer behavioural context and examine how these animals interact with their physical environment...
August 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30120163/fda-approval-summary-pembrolizumab-for-recurrent-locally-advanced-or-metastatic-gastric-or-gastroesophageal-junction-adenocarcinoma-expressing-pd-l1
#5
Lola Fashoyin-Aje, Martha Donoghue, Huanyu Chen, Kun He, Janaki Veeraraghavan, Kirsten B Goldberg, Patricia Keegan, Amy E McKee, Richard Pazdur
On September 22, 2017, the U.S. Food and Drug Administration (FDA) granted accelerated approval for pembrolizumab (Keytruda, Merck & Co., Inc., Whitehouse Station, NJ) for the treatment of patients with recurrent, locally advanced or metastatic, gastric or gastroesophageal junction (GEJ) adenocarcinoma with disease progression on or after two or more systemic therapies, including fluoropyrimidine- and platinum-containing chemotherapy and, if appropriate, HER2/neu-targeted therapy, and whose tumors express programmed death-ligand 1 (PD-L1), as determined by an FDA-approved test...
August 17, 2018: Oncologist
https://www.readbyqxmd.com/read/30120027/concurrent-assessment-of-cartilage-morphology-and-bone-microarchitecture-in-the-human-knee-using-contrast-enhanced-hr-pqct-imaging
#6
Geoffrey J Michalak, Richard Walker, Steven K Boyd
Osteoarthritis (OA) is a prevalent articular disease characterized by whole joint degradation, including articular cartilage and bone. Presently, no single imaging modality is well suited to concurrently capture these changes. Recent ex vivo animal studies have demonstrated the efficacy of utilizing contrast agents in conjunction with micro-CT as a means of evaluating cartilage and bone alterations concurrently, though no work as of yet has been performed in large animal models or humans. This study sought to develop and validate a novel joint imaging technique, contrast enhanced high resolution peripheral quantitative computed tomography (CEHR-pQCT), to concurrently assess bone microarchitecture and cartilage morphology in the whole human knee...
July 19, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/30119899/short-and-intermediate-term-outcomes-of-hybrid-coronary-revascularization-for-double-vessel-disease
#7
Nirav C Patel, Jonathan M Hemli, Michael C Kim, Karthik Seetharam, Luigi Pirelli, Derek R Brinster, S Jacob Scheinerman, Varinder P Singh
OBJECTIVE: We sought to evaluate midterm survival data and resource use for patients who received hybrid coronary revascularization for 2-vessel coronary disease (robotic-assisted left internal thoracic artery graft to left anterior descending coronary artery (minimally invasive direct coronary artery bypass), coupled with a stent to the circumflex or right coronary artery), compared with a concurrent cohort who had traditional coronary artery bypass grafting. METHODS: A comprehensive retrospective review was undertaken of our prospectively collected database from January 2009 to December 2016...
April 30, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30119345/high-sampling-rate-single-pixel-digital-holography-system-employing-a-dmd-and-phase-encoded-patterns
#8
Humberto González, Lluís Martínez-León, Fernando Soldevila, Ma Araiza-Esquivel, Jesús Lancis, Enrique Tajahuerce
A single-pixel digital holography system with phase-encoded illumination using a digital micromirror device (DMD) as a spatial light modulator (SLM) is presented. The enhanced switching rate of DMDs, far exceeding the stringent frame-rate of liquid crystal SLMs, allows recording and reconstruction of complex amplitude distributions in just a few seconds. A single amplitude binary modulation device is used for concurrently displaying the phase-encoded sampling patterns, compensating the distortion of the wavefront, and applying phase-shifting, by means of computer generated holograms...
August 6, 2018: Optics Express
https://www.readbyqxmd.com/read/30119216/withaferin-a-attenuates-multiple-low-doses-of-streptozotocin-mld-stz-induced-type-1-diabetes
#9
Sravani Tekula, Amit Khurana, Pratibha Anchi, Chandraiah Godugu
Type 1 diabetes mellitus (T1DM) is one of the major metabolic disorders with life-long dependence on insulin. The present study was designed to evaluate the antioxidant and anti-diabetic potential of Withaferin A (WA), the active constituent of Withania somnifera in multiple low doses of Streptozotocin (MLD-STZ) induced T1DM. STZ (40 mg/Kg) was administered intraperitoneally (i.p.) for 5 consecutive days to male Swiss albino mice to induce T1DM. Mice were concurrently treated with WA (2 & 10 mg/Kg)...
July 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30118646/the-protective-role-of-melatonin-in-chemotherapy-induced-nephrotoxicity-a-review-of-non-clinical-studies
#10
Hamed Haghi-Aminjan, Bagher Farhoud, Mahban Rahimifard, Tina Didari, Maryam Baeeri, Shokoufeh Hassani, Rohollah Hosseini, Mohammad Abdollahi
Chemotherapy agents are widely and effectively used for the treatment of different malignant tumors. Nonetheless, their use may lead to different adverse outcomes such as nephrotoxicity which is the main cause of morbidity and hospitalization of patients in intensive care units. Melatonin is a small molecule with pleiotropic healing properties and effectiveness in the management of a wide range of diseases. The aim of this study was to investigate the potential role of melatonin in the prevention of chemotherapy-induced nephrotoxicity at the preclinical level...
August 17, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/30118562/polyprodrug-antimicrobials-remarkable-membrane-damage-and-concurrent-drug-release-to-combat-antibiotic-resistance-of-methicillin-resistant-staphylococcus-aureus
#11
Bing Cao, Fengfeng Xiao, Da Xing, Xianglong Hu
The increased threat of antibiotic resistance has created an urgent need for new strategies. Herein, polyprodrug antimicrobials are proposed to mimic antimicrobial peptides appended with a concurrent drug release property, exhibiting broad-spectrum antibacterial activity and especially high potency to inhibit methicillin-resistant Staphylococcus aureus (MRSA) without inducing resistance. Two series of polyprodrug antimicrobials are fabricated by facile polymerization of triclosan prodrug monomer (TMA) and subsequent quaternization of hydrophilic poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA), affording PDMAEMA-b-PTMA and PQDMA-b-PTMA, respectively...
August 17, 2018: Small
https://www.readbyqxmd.com/read/30118250/observation-of-efficient-lower-hybrid-current-drive-at-high-density-in-diverted-plasmas-on-the-alcator-c-mod-tokamak
#12
S G Baek, G M Wallace, P T Bonoli, D Brunner, I C Faust, A E Hubbard, J W Hughes, B LaBombard, R R Parker, M Porkolab, S Shiraiwa, S Wukitch
Efficient lower hybrid current drive (LHCD) is demonstrated at densities up to n[over ¯]_{e}≈1.5×10^{20}  m^{-3} in diverted plasmas on the Alcator C-Mod tokamak by operating at increased plasma current-and therefore reduced Greenwald density fraction. This density exceeds the nominal "LH density limit" at n[over ¯]_{e}≈1.0×10^{20}  m^{-3} reported previously, above which an anomalous loss of current drive efficiency was observed. The recovery of current drive efficiency to a level consistent with engineering scalings is correlated with a reduction in density shoulders and turbulence levels in the far scrape-off layer...
August 3, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30118239/susceptibility-of-antibody-cdr-residues-to-chemical-modifications-can-be-revealed-prior-to-antibody-humanization-and-aid-in-the-lead-selection-process
#13
Ankai Xu, Hok Seon Kim, Samarkand Estee, Sharon ViaJar, William J Galush, Avinash Gill, Isidro Hotzel, Greg A Lazar, Paul McDonald, Nisana Andersen, Christoph Spiess
A critical part of the clinical development path for a therapeutic antibody involves evaluating the physical and chemical stability of candidate molecules throughout the manufacturing process. In particular, the risks of chemical liabilities which can impact antigen binding, such as deamidation, oxidation, and isomerization in the antibody CDR sequences, need to be controlled through formulation development or eliminated by replacing the amino acid motif displaying the chemical instability. Commonly, the antibody CDR sequence contains multiple sequence motifs (potential hotspots) for chemical instability...
August 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30118203/recent-developments-in-the-scope-practicality-and-mechanistic-understanding-of-enantioselective-hydroformylation
#14
Anna C Brezny, Clark R Landis
In the nearly 80 years since catalytic hydroformylation was first reported, hundreds of billions of pounds of aldehyde have been produced by this atom efficient one-carbon homologation of alkenes in the presence of H2 and CO. Despite the economy and demonstrated scalability of hydroformylation, the enantioselective process (asymmetric hydroformylation, AHF) currently does not contribute significantly to the production of chiral aldehydes and their derivatives. Current impediments to practical application of AHF include low diversity of chiral ligands that provide effective rates and selectivities, limited exploration of substrate scope, few demonstrations of efficient flow reactor processes, and incomplete mechanistic understanding of the factors that control reaction selectivity and rate...
August 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30117783/a-potential-biomarker-for-predicting-the-risk-of-radiation-induced-fibrosis-in-the-lung
#15
Angela M Groves, Jacqueline P Williams, Eric Hernady, Christina Reed, Bruce Fenton, Tanzy Love, Jacob N Finkelstein, Carl J Johnston
Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and complicated by concurrent trauma. Used alongside biodosimetry, biomarkers can identify victims in need of treatment for acute radiation effects, and might also provide valuable information on later developing consequences that need to be addressed as part of a treatment strategy. Indeed, because the lung is particularly sensitive to radiation and resultant late effects not only affect quality of life, but can also lead to morbidity, the risk of developing downstream pulmonary complications in exposed individuals requires assessment...
August 17, 2018: Radiation Research
https://www.readbyqxmd.com/read/30117763/total-improvement-after-surgery-for-obstructive-sleep-apnea-syndrome-in-a-patient-with-concurrent-malignant-idiopathic-intracranial-hypertension
#16
Halil Onder, Onur Ergun, Mehmet Kaygisiz, I Samet Daltaban
The association between idiopathic intracranial hypertension (IIH) and obstructive sleep apnea syndrome (OSAS) constitutes an interesting point of discussion regarding clinical approaches as well as the underlying pathophysiological mechanisms. Here, the case of a 42-year-old female with malignant IIH and OSAS is illustrated. Initially, the patient was treated with lumboperitoneal shunt surgery. However, OSAS surgery provided total recovery from the recurrent symptoms developing secondary to lumboperitoneal shunt malfunction...
August 17, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30117381/-17-is-odd-and-seventeen-is-even-meaning-and-physical-form-in-stimulus-parity-synaesthesia
#17
Rebekah C White, Tsvetomira Dumbalska, Mihaela D Duta, Kate Nation
For individuals with stimulus-parity synaesthesia, eliciting stimuli (e.g., shapes, numbers, letters, colours) trigger a compelling feeling of oddness or evenness. Given that (a) many inducers are conceptual and (b) parity is itself a conceptual property, one questions whether stimulus-parity synaesthesia will be a categorically higher subtype, such that the conceptual properties of stimuli will be crucial in determining parity. We explore this question as it applies to Synaesthete R, one of only two stimulus-parity synaesthetes known to the contemporary literature...
September 2018: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/30117354/patterns-of-aggressive-behaviors-across-mental-health-in-sixth-graders
#18
Melissa J DuPont-Reyes, Alice P Villatoro, Jo C Phelan, Kris Painter, Bruce G Link
School-based violence is a current public concern in the United States. One factor that can impact school-based violence that has gained much attention is mental health status. To better inform public perceptions, this study provides new evidence concerning the association between mental health status and acting out violence in school-aged populations. We examined a diverse sample of sixth graders across 14 schools in Texas in 2011-2012 ( N = 721) who completed a self-administered survey assessing mental health symptoms and frequency of perpetration and/or receipt of different types of aggressive behaviors...
August 17, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/30117300/evaluation-of-the-cardiac-safety-of-long-acting-endectocide-moxidectin-in-a-randomized-concentration-qt-study
#19
Sally AKinrade, Jay W Mason, Carlos R Sanabria, Craig R Rayner, Julie M Bullock, Stephanie H Stanworth, Mark T Sullivan
Potential effects on cardiac repolarization of single doses of moxidectin, a potent long-acting macrocyclic lactone endectocide, were assessed in a concentration-QT (exposure-response) study. This double-blind, placebo-controlled, parallel-group study in healthy male volunteers (n=60) randomized subjects to a single oral dose of moxidectin (4 mg, 8 mg, 16 mg, 24 mg, or 36 mg) or matching placebo. Serial plasma samples for pharmacokinetic analysis and concurrent triplicate electrocardiogram measurements were taken at baseline and 14 pre-specified time points over 72 hours, yielding 900 QT interval-plasma concentration time-matched pairs...
August 17, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/30117260/response-rate-to-a-single-dose-of-vinblastine-administered-to-dogs-with-treatment-naive-multicentric-lymphoma
#20
K Harding, N Bergman, A Smith, S Lindley, A Szivek, R Milner, W Brawner, A Lejeune
Vincristine is included in vincristine, cyclophosphamide, doxorubicin and prednisone (CHOP) chemotherapy protocols, which are the gold-standard treatment for high-grade canine lymphoma. Vincristine can result in relatively high rates of gastrointestinal toxicity, whereas vinblastine is generally well tolerated and thus may represent an under-utilized and minimally toxic alternative to vincristine. Our objective was to determine the response rate and toxicity associated with a single dose of vinblastine administered to dogs with treatment-naïve, intermediate to large-cell, multicentric lymphoma...
August 16, 2018: Veterinary and Comparative Oncology
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