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Shaik Afsar Pasha, Shaik Arif Pasha, T Suhasini, D Ankamma Rao
Hepatitis E virus (HEV) is a common infection worldwide and is an emerging infectious disease in the developed countries. The unique characteristics of HEV is that it displays different epidemiological and clinical characteristics between developing and developed countries. Neurological disorders are emerging extra hepatic manifestations of both acute and chronic Hepatitis E virus infection. We report a 17 year old sportsman presenting with acute encephalitic Parkinsonism concurrent with acute hepatitis. Serology was positive for Hepatitis E virus (HEV) and HEV RNA was confirmed...
March 2018: Journal of the Association of Physicians of India
Brian Ezekian, Michael S Mulvihill, Paul M Schroder, Brian F Gilmore, Harold J Leraas, Brian C Gulack, Sarah Jane Commander, Alisha M Mavis, Susan G Kreissman, Stuart J Knechtle, Elisabeth T Tracy, Andrew S Barbas
PURPOSE: Improvement in outcomes of LT for pediatric HB and HCC has been reported in small series. We analyzed national outcomes and changes in donor, recipient, and perioperative factors over time that may contribute to survival differences. METHODS: The UNOS database was queried for patients age <21 years that underwent LT for a primary diagnosis of HB or HCC (1987-2017). Subjects were divided into historic (transplant before 2010) and contemporary (transplant after 2010) cohorts...
October 19, 2018: Pediatric Transplantation
Jungyeon Choi, Olaf M Dekkers, Saskia le Cessie
Propensity score analysis is a popular method to control for confounding in observational studies. A challenge in propensity methods is missing values in confounders. Several strategies for handling missing values exist, but guidance in choosing the best method is needed. In this simulation study, we compared four strategies of handling missing covariate values in propensity matching and propensity weighting. These methods include: complete case analysis, missing indicator method, multiple imputation and combining multiple imputation and missing indicator method...
October 19, 2018: European Journal of Epidemiology
Baubak Shamim, Brooke L Devlin, Ryan G Timmins, Paul Tofari, Connor Lee Dow, Vernon G Coffey, John A Hawley, Donny M Camera
BACKGROUND: We implemented a high-protein diet (2 g·kg-1 ·d-1 ) throughout 12 weeks of concurrent exercise training to determine whether interferences to adaptation in muscle hypertrophy, strength and power could be attenuated compared to resistance training alone. METHODS: Thirty-two recreationally active males (age: 25 ± 5 years, body mass index: 24 ± 3 kg·m-2 ; mean ± SD) performed 12 weeks of either isolated resistance (RES; n = 10) or endurance (END; n = 10) training (three sessions·w-1 ), or concurrent resistance and endurance (CET; n = 12) training (six sessions·w-1 )...
October 19, 2018: Sports Medicine
Michelle N Messmer, Annelise G Snyder, Andrew Oberst
Our conception of programmed cell death has expanded beyond apoptosis to encompass additional forms of cell suicide, including necroptosis and pyroptosis; these cell death modalities are notable for their diverse and emerging roles in engaging the immune system. Concurrently, treatments that activate the immune system to combat cancer have achieved remarkable success in the clinic. These two scientific narratives converge to provide new perspectives on the role of programmed cell death in cancer therapy. This review focuses on our current understanding of the relationship between apoptosis and antitumor immune responses and the emerging evidence that induction of alternate death pathways such as necroptosis could improve therapeutic outcomes...
October 19, 2018: Cell Death and Differentiation
Jason Watterson, B Gabbe, P Dietze, A Bowring, J V Rosenfeld
BACKGROUND: The Alcohol Use Disorders Identification Test (AUDIT) is widely used for monitoring harmful alcohol consumption among high-risk populations. A number of short versions of AUDIT have been developed for use in time-constrained settings. In military populations, a range of AUDIT variations have been used, but the optimal combination of AUDIT items has not been determined. METHODS: A total of 952 participants (80% male), recruited as part of a wider study, completed the AUDIT-10...
October 18, 2018: Journal of the Royal Army Medical Corps
Mohammed Yousufuddin, Nathan Young, Jessica Shultz, Taylor Doyle, Karen M Fuerstenberg, Kelsey Jensen, Kogulavadanan Arumaithurai, Mohammad H Murad
BACKGROUND: We examined predictors of recurrent hospitalizations and the importance of these hospitalizations for subsequent mortality after incident transient ischemic attacks (TIA) that have not yet been investigated. METHODS: Adults hospitalized for TIA from 2000 through 2017 were examined for recurrent hospitalizations, days, and percentage of time spent hospitalized and long-term mortality. RESULTS: Of 266 patients hospitalized for TIA, 122 died, 212 had 826 anycondition hospitalization (59 from TIA-related conditions) corresponding to 3384 inpatient days during 1693 person-years of follow-up...
October 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Ann Quinlan-Colwell, Kathleen Broglio, Diana Rae, Debra J Drew, Carolyn C Brown, Kimberly Fetty
BACKGROUND: A task force of members of the American Society for Pain Management Nursing (ASPMN) authored a position paper "Prescribing and Administering Opioid Doses Based Solely on Pain Intensity." Some of the authors of this ASPMN position paper presented a concurrent session at the September 2016 ASPMN National Conference discussing the content of the position paper. As a follow-up, the authors designed a research study to identify the impact of the position statement in facilitating change in institutional practice of dosing analgesics based solely on pain intensity...
October 16, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
Ronnel B King, Jesus Alfonso D Datu
Previous research on gratitude has mostly focused on its effects on well-being. However, scant attention has been paid to how gratitude is associated with key learning-related outcomes. The aim of this series of studies was to examine how gratitude is associated with students' motivation, engagement, and achievement. Study 1, a cross-sectional study, found that gratitude was positively associated with higher levels of autonomous motivation and engagement (rs ranging from 0.17 to 0.20, p < .05). Study 2, a longitudinal study, found that gratitude was concurrently and prospectively associated with autonomous motivation (rs ranging from 0...
October 2018: Journal of School Psychology
Jason Hinton, Alberto Cerra-Franco, Kevin Shiue, Lindsey Shea, Vasantha Aaron, Geoffrey Billows, Ahmad Al-Hader, Tim Lautenschlaeger
BACKGROUND: The incidence of superior vena cava syndrome within the United States is roughly 15,000 cases per year. Superior vena cava syndrome is a potentially life-threatening medical condition; however, superior vena cava syndrome is not fatal in the majority of cases. Superior vena cava syndrome encompasses a collection of signs and symptoms resulting from obstruction of the superior vena cava, including swelling of the upper body of the head, neck, arms, and/or breast. It is also associated with cyanosis, plethora, and distended subcutaneous vessels...
October 20, 2018: Journal of Medical Case Reports
Michael S Sagmeister, Max Weiss, Peter Eichhorn, Antje Habicht, Rupert Habersetzer, Michael Fischereder, Ulf Schönermarck
BACKGROUND: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis causes end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but new onset of ANCA-associated vasculitis after transplantation is highly unusual. The use of rituximab or plasmapheresis for de novo disease after transplantation has not previously been reported. CASE PRESENTATION: Routine post-transplant follow-up for a 66-year old asymptomatic woman revealed a rise in creatinine from 1...
October 19, 2018: BMC Nephrology
Ying Liu, Ben-Chung Cheng, Jien-Wei Liu, Chiao-Jung Chen, Li-Chueh Kuo, Wen Xiu Chang, Jin-Bor Chen
BACKGROUND: The clinical course of Viridans streptococci (VS) peritonitis in patients undergoing peritoneal dialysis (PD) is rarely reported. This study examined the association of clinical factors with VS peritonitis. METHODS: We retrospectively reviewed clinical data from patients with VS peritonitis from March 1990 to February 2016 in a PD center in Taiwan and evaluated clinical profiles and treatment outcomes. RESULTS: A total of 109 episodes of VS peritonitis in 71 patients identified...
October 19, 2018: BMC Nephrology
Alyssa A Riley, Mary Watson, Carolyn Smith, Danielle Guffey, Charles G Minard, Helen Currier, Ayse Akcan Arikan
BACKGROUND: To evaluate changes in population characteristics and outcomes in a large single-center pediatric patient cohort treated with continuous renal replacement therapy (CRRT) over a 10 year course, coincident with multiple institutional practice changes in CRRT delivery. METHODS: A retrospective cohort study with comparative analysis of all patients treated from 2004 to 2013 with CRRT in the neonatal, pediatric, and cardiovascular intensive care units within a free-standing pediatric tertiary care hospital...
October 19, 2018: BMC Nephrology
Gabhan Chalmers, Kelly M Rozas, Raghavendra G Amachawadi, Harvey Morgan Scott, Keri N Norman, Tiruvoor G Nagaraja, Mike D Tokach, Patrick Boerlin
Copper is used as an alternative to antibiotics for growth promotion and disease prevention. However, bacteria developed tolerance mechanisms for elevated copper concentrations, including those encoded by the pco operon in Gram-negative bacteria. Using cohorts of weaned piglets, this study showed that the supplementation of feed with copper concentrations as used in the field did not result in a significant short-term increase in the proportion of pco -positive fecal Escherichia coli . The pco and sil (silver resistance) operons were found concurrently in all screened isolates, and whole-genome sequencing showed that they were distributed among a diversity of unrelated E...
October 18, 2018: Genes
Katja F Düsterdieck-Zellmer
Systemic administration of tiludronate or clodronate decreases lameness in some horses suffering from navicular syndrome within 2-6 months of treatment. In horses that fail to respond to the first treatment, a follow-up treatment may still improve the lameness. Horses with a lameness duration of less than 6 months have better odds of experiencing improvement in lameness. Bisphosphonate (BP) treatment can result in renal damage, and it is recommended to assess renal function prior to and after treatment. Horses with pre-existing renal compromise should not be treated with BP, as this may promote deterioration of their renal status...
October 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Philip Brown, Adam Daigneault, Joshua Dawson
Governments such as New Zealand's seek to raise the value of agricultural exports while concurrently protecting the natural environment. Therefore, farmers are encouraged to increase production while reducing environmental impacts. In this paper, we analyse the relationship between age and farmer values, farming objectives, past management decisions, and future intentions, all of which may impact the environment. Using multivariate regression that controls for gender, education, industry, and region, we find that older farmers are more risk averse, less willing to experiment, less likely to be influenced by social expectations, and more focused on financial performance...
October 16, 2018: Journal of Environmental Management
Jatziri Mota-Gutierrez, Ilario Ferrocino, Kalliopi Rantsiou, Luca Cocolin
Next-generation sequencing has been used to strengthen knowledge about taxonomic diversity and ecology of fungi within food ecosystems. However, primer amplification and identification bias could edge our understanding into the fungal ecology. The aim of this study is to compare the performance of two primer pairs over two nuclear ribosomal RNA (rRNA) regions of the fungal kingdom, namely the ITS2 and 26S regions. Fermented cocoa beans were employed as biological material and the fungal ecology during fermentation was studied using amplicon-based sequencing tools, making use of a manually curated 26S database constructed in this study, and validated with SILVA's database...
October 10, 2018: International Journal of Food Microbiology
Griffin Boll, Ariel Fischer, Navin Kapur, Payam Salehi
BACKGROUND: Impella 5.0 is a powerful mechanical circulatory support device placed into the left ventricle of patients in cardiogenic shock not responding to pharmacologic support alone. This therapy can support patient hemodynamics from weeks to several months, and patients can potentially ambulate with the device implanted while awaiting destination therapy. METHODS: From July 2012 to September 2017, twenty-two Impella 5.0 devices (Abiomed Inc., Danvers, MA) were implanted via right axillary artery at our center...
October 16, 2018: Annals of Vascular Surgery
Monika Sarkar, Jennifer C Lai, Deirdre Sawinski, Toni E Zeigler, Marcelle Cedars, Kimberly A Forde
Cirrhosis is associated with hormonal dysregulation, as evidenced by secondary amenorrhea in reproductive-aged women, and feminization of cirrhotic men. Whether hormone levels vary by severity of cirrhosis in women is not known. If identified, such changes may have important clinical relevance, particularly as low sex hormone binding globulin (SHBG) and follicle stimulating hormone (FSH) are known to promote metabolic and cardiovascular disease in women. In a cohort of post-menopausal women with chronic hepatitis C virus (HCV) infection, we compared comprehensive sex hormone levels by presence of cirrhosis, as well as across Child-Turcotte-Pugh (CTP) class...
October 19, 2018: Journal of Viral Hepatitis
Luis Grau, Erik Zachwieja, Spencer H Summers, Dustin H Massel, Alvin Ong, Victor H Hernandez, Omri Merose
OBJECTIVE: To evaluate the relationship between noncirrhotic hepatitis C virus (HCV) infection, perioperative complications, and discharge status in patients undergoing surgical procedures for hip fractures. METHODS: A retrospective epidemiological study was performed, querying the National Hospital Discharge Survey. Patients were selected using the International Classification of Diseases-9 diagnostic codes for hip fracture and primary procedural codes for open reduction internal fixation, hemiarthroplasty, total hip arthroplasty, or internal fixation...
November 2018: Journal of Orthopaedic Trauma
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