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“Patient safety”

Richard Williams
BACKGROUND: Pre-registration nursing programmes aim to prepare students to function effectively within an environment that provides front-line health care, with the over-riding concern being patient safety. Exhibiting the ability to assess practice-based situations and make decisions is critical to demonstrating effective clinical, professional and leadership competence. AIM: This small scale qualitative study explores first year student nurses' understanding of the importance of recording achievement of practice competence and identifying the factors which influence them when prioritising completion of their Practice Assessment Record...
October 5, 2018: Nurse Education Today
S Cheleschi, A Fioravanti, A De Palma, C Corallo, D Franci, N Volpi, G Bedogni, S Giannotti, N Giordano
Nutraceuticals are compounds that serve as nutrition with an easy accessibility and favourable safety profile. Recent studies showed their potential activity on osteoarthritis (OA) inflammation and cartilage metabolism. We investigated the effect of methylsulfonylmethane (MSM) and mobilee in human OA chondrocyte cultures exposed to interleukin (IL)-1β. OA cartilage was obtained from femoral heads of five patients undergoing total replacement surgery. Chondrocytes were incubated with mobilee (200 and 500 μM) and MSM (2000 and 6000 μM) in presence of IL-1β (10 ng/mL) and nuclear factor (NF)-κB inhibitor (BAY 11-7082, 1 μM), for 24 and 48 h...
October 10, 2018: International Immunopharmacology
Anastasia N L Newman, Janelle Gravesande, Stephanie Rotella, Stephen S Wu, Nam Topp-Nguyen, Michelle E Kho, Jocelyn E Harris, Alison Fox-Robichaud, Patricia Solomon
PURPOSE: This scoping review summarizes the literature on the safety and effectiveness of physiotherapy interventions in patients with neurological and/or traumatic injuries in the intensive care unit (ICU), identifies literature gaps and provides recommendations for future research. MATERIALS AND METHODS: We searched five databases from inception to June 2, 2018. We included published retrospective studies, case studies, observation and randomized controlled trials describing physiotherapy interventions in ICU patients with neurotrauma injuries...
October 3, 2018: Journal of Critical Care
Jiro Okami, Yasushi Shintani, Meinoshin Okumura, Hiroyuki Ito, Takashi Ohtsuka, Shinichi Toyooka, Takeshi Mori, Shun-Ichi Watanabe, Hiroshi Date, Kohei Yokoi, Hisao Asamura, Takeshi Nagayasu, Etsuo Miyaoka, Ichiro Yoshino
INTRODUCTION: The Japanese Joint Committee of Lung Cancer Registry (JJCLCR) performed the fourth nationwide registry study of surgical cases. Demographics, safety and quality, prognostic information, and correlations between the 7th and the 8th editions of the TNM classification were investigated. The principal results were compared with previous JJCLCR studies. METHODS: The clinicopathologic profiles, staging, and prognosis of patients who underwent surgery for primary lung cancer in 2010 were retrospectively collected in 2016 and analyzed...
October 10, 2018: Journal of Thoracic Oncology
Neal Ready, Anna F Farago, Filippo de Braud, Akin Atmaca, Matthew D Hellmann, Jeffrey G Schneider, David R Spigel, Victor Moreno, Ian Chau, Christine L Hann, Joseph Paul Eder, Nicola L Steele, Anne Pieters, Justin Fairchild, Scott J Antonia
INTRODUCTION: For patients with recurrent small cell lung cancer (SCLC), topotecan remains the only FDA-approved or EMA-approved second-line treatment, and outcomes are poor. CheckMate 032 is a phase 1/2, multicenter, open-label study of nivolumab or nivolumab plus ipilimumab in SCLC or other advanced/metastatic solid tumors previously treated with ≥1 platinum-based chemotherapies. We report results of third- or later-line (3L+) nivolumab monotherapy treatment in SCLC. METHODS: In this analysis, patients with limited-stage or extensive-stage SCLC and disease progression after ≥2 chemotherapy regimens received nivolumab monotherapy 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity...
October 10, 2018: Journal of Thoracic Oncology
Laura Escolà-Vergé, Nuria Fernández-Hidalgo, Dolors Rodríguez-Pardo, Carlos Pigrau, Juan José González-López, Rosa Bartolomé, Benito Almirante
BACKGROUND: The objective of this study was to evaluate the effectiveness and safety of teicoplanin for treating enterococcal infective endocarditis (EIE). METHODS: We performed a retrospective analysis of a prospective cohort of definite EIE patients treated with teicoplanin in a referral center (January 2000-September 2017). Primary outcome was mortality during treatment. Secondary outcomes were mortality during a 3-month follow-up, adverse effects, and relapse...
October 10, 2018: International Journal of Antimicrobial Agents
Gaby N Moawad, Paul Tyan, Charbel Awad
STUDY OBJECTIVE: In this surgical tutorial, we present technical pointers and suggestions that would enable gynecologic surgeons to achieve difficult tissue containment and extraction for numerous and large myomas in the complex minimally invasive myomectomy setting. DESIGN: A step by-step explanation of the surgery using video (instructive video), exempt by the local Institutional Review Board. (Canadian Task Force classification level III). IRB approval was not required for this study...
October 10, 2018: Journal of Minimally Invasive Gynecology
Michael Cornes, Mercedes Ibarz, Helene Ivanov, Kjell Grankvist
It has been well documented over recent years that the pre-analytical phase is a leading contributor to errors in the total testing process (TTP). There has however been great progress made in recent years due to the exponential growth of working groups specialising in the field. Patient safety is clearly at the forefront of any healthcare system and any reduction in errors at any stage will improve patient safety. Venous blood collection is a key step in the TTP, and here we review the key errors that occur in venous phlebotomy process and summarise the evidence around their significance to patient safety...
October 13, 2018: Diagnosis
Yogita Kanan, Mahmood Khan, Valeria E Lorenc, Da Long, Rishi Chadha, Jason Sciamanna, Ken Green, Peter A Campochiaro
Metipranolol is a β-adrenergic receptor antagonist that is given orally for the treatment of hypertension and also applied topically to the cornea for treating glaucoma. It also inhibits nitrosative stress which has previously been shown to be the cause of cone photoreceptor death in retinitis pigmentosa (RP). In this study, we tested the hypothesis that metipranolol protects photoreceptor structure and function in the mouse model rd10. At P35, compared with vehicle-treated rd10 mice in which rod degeneration was nearly complete, rd10 mice given daily subcutaneous injections of 40 mg/kg of metipranolol had reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer (ONL) thickness, and substantially more staining for rhodopsin...
October 13, 2018: Journal of Neurochemistry
F Böckelmann, M Hammon, S Lettmaier, R Fietkau, C Bert, F Putz
OBJECTIVE: This study aimed to assess the reduction in dose to the penile bulb (PB) achieved by MRI-based contouring following drinking and endorectal balloon (ERB) instructions. PATIENTS AND METHODS: A total of 17 prostate cancer patients were treated with intensity-modulated radiation therapy (IMRT) and interstitial brachytherapy (IBT). CT and MRI datasets were acquired back-to-back based on a 65 cm3 air-filled ERB and drinking instructions. After rigid co-registration of the imaging data, the CT-based planning target volume (PTV) used for treatment planning was retrospectively compared to an MRI-based adaptive PTV and the dose to the PB was determined in each case...
October 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Angelo Ghezzi
The management and treatment of multiple sclerosis (MS) is becoming more and more complex as many medications are now available, with different routes of administration, mechanisms of action, and effectiveness and safety profiles. The decision-making process to choose the right medication is a complex task requiring a careful evaluation of the results of clinical and post-marketing studies, and the capability to translate data from clinical studies to patients in everyday clinical practice. Two European neurological societies, the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and European Academy of Neurology (EAN), and the American Academy of Neurology (AAN) have recently delivered guidelines for MS treatment, helping neurologists to address the most common clinical issues related to this topic...
October 12, 2018: Neurology and Therapy
Mar Tintore, Angela Vidal-Jordana, Jaume Sastre-Garriga
The modern era of multiple sclerosis (MS) treatment began 25 years ago, with the approval of IFNβ and glatiramer acetate for the treatment of relapsing-remitting MS. Ten years later, the first monoclonal antibody, natalizumab, was approved, followed by a third important landmark with the introduction of oral medications, initially fingolimod and then teriflunomide, dimethyl fumarate and cladribine. Concomitantly, new monoclonal antibodies (alemtuzumab and ocrelizumab) have been developed and approved. The modern era of MS therapy reached primary progressive MS in 2018, with the approval of ocrelizumab...
October 12, 2018: Nature Reviews. Neurology
David M Ross, Ilaria S Pagani, Naranie Shanmuganathan, Chung H Kok, John F Seymour, Anthony K Mills, Robin J Filshie, Christopher K Arthur, Phuong Dang, Verity A Saunders, Jodi Braley, Agnes S Yong, David T Yeung, Deborah L White, Andrew P Grigg, Anthony P Schwarer, Susan Branford, Timothy P Hughes
Following the achievement of deep molecular response on tyrosine kinase inhibitors (TKIs), approximately half of patients with chronic myeloid leukemia (CML) can discontinue TKI and remain in treatment-free remission (TFR). The ALLG CML8 study enrolled 40 imatinib-treated patients with undetectable BCR-ABL1 mRNA (approximately MR4.5 ). Molecular relapse was defined as detectable BCR-ABL1 on two consecutive tests or any single value >0.1%. With a median follow-up of 8.6 years (range 5.7-11.2 years), 18 patients remain in continuous TFR (45...
October 12, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
David Michelson, Emma Ciafaloni, Stephen Ashwal, Elliot Lewis, Pushpa Narayanaswami, Maryam Oskoui, Melissa J Armstrong
OBJECTIVE: To identify the level of evidence for use of nusinersen to treat spinal muscular atrophy (SMA) and review clinical considerations regarding use. METHODS: The author panel systematically reviewed nusinersen clinical trials for patients with SMA and assigned level of evidence statements based on the American Academy of Neurology's 2017 therapeutic classification of evidence scheme. Safety information, regulatory decisions, and clinical context were also reviewed...
October 12, 2018: Neurology
Roberto Cirocchi, Nicola Fearnhead, Nereo Vettoretto, Diletta Cassini, Georgi Popivanov, Brandon Michael Henry, Krzysztof Tomaszewski, Vito D'Andrea, Justin Davies, Salomone Di Saverio
BACKGROUND: Nowadays sigmoidectomy is recommended as "gold standard" treatment for generalized purulent or faecal peritonitis from sigmoid perforated diverticulitis. This systematic review and meta-analysis aimed to assess effectiveness and safety of laparoscopic access versus open sigmoidectomy in acute setting. METHODS: A systematic literature search was performed for randomized controlled trials (RCTs) and non-RCTs published in PubMed, SCOPUS and Web of Science...
October 9, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Xizhong Zhu, Liu Yang, Xiaojun Duan
Symptomatic cystic lesions of the talus are rare. The traditional operations usually do not provide visualization to reveal the deep structure of the lesion and could cause cartilage damage or other severe traumatic injury. We report an operative technique to reach the cystic lesion without talar cartilage damage, remove the lesion, and fill defect with a bone graft assisted by anterior arthroscopy and evaluate its safety and reliability for future study. Seven cases of talar bone cyst were included. The patients were placed in the supine position after anesthesia induction and noninvasive ankle traction was applied...
October 9, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Mark Froats, Andrew Reed, Richard Dionne, Justin Maloney, Susan Duncan, Rob Burns, Julie Sinclair, Michael Austin
BACKGROUND: Most patients transferred from a non-percutaneous coronary intervention (PCI) facility for primary PCI do not meet target reperfusion times. Direct transportation of patients with ST-elevation myocardial infarction (STEMI) from the scene by advanced life support (ALS) paramedics has been shown to improve reperfusion times and outcomes. OBJECTIVE: The aim of this study was to determine whether it is safe to bypass the closest hospital and transport by basic life support (BLS) provider to a PCI facility...
October 9, 2018: Journal of Emergency Medicine
Jaehee Ahn, Dae Won Jun, Hyo Young Lee, Jin Hwa Moon
BACKGROUND & AIMS: Weight loss by lifestyle modification is the cornerstone therapy of Non Alcoholic Fatty Liver Disease. Low carbohydrate diet has showed favorable effects for body weight as well as hepatic fat content in several reports. In this meta-analysis, we review clinical studies article to date regarding the composition of the diet and analyzed the impact of low carbohydrate diet comparing to low calorie diet on hepatic fat change, AST and ALT using Forest plot. We aimed to investigate the efficacy of low carbohydrate diet on NAFLD...
September 25, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Alfonso Ielasi, Gianluca Campo, Bernardo Cortese, Massimo Leoncini, Attilio Varricchio, Salvatore Brugaletta, Enrico Favaretto, Massimo Fineschi, Davide Piraino, Paolo Calabria, Francesco Granata, Francesco Pisano, Marco Mussardo, Azeem Latib, Maurizio Tespili
BACKGROUND: data from clinical experiences with Absorb bioresorbable scaffold (BRS) in STEMI raised concerns among clinicians about the device safety because a noteworthy scaffold thrombosis (ScT) rate was reported at early and long-term follow-up. Nevertheless, pre-specified technical suggestions of how to perform an optimal BRS procedure in STEMI were lacking. In this study we sought to assess the 1-year results following a pre-specified BRS implantation strategy in ST-elevation myocardial infarction (STEMI) patients undergoing primary PCI (pPCI)...
October 4, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Michael Koutouzis, Eleftherios Kontopodis, Andreas Tassopoulos, Ioannis Tsiafoutis, Konstantina Katsanou, Aggeliki Rigatou, Matthaios Didagelos, Konstantinos Andreou, Efstathios Lazaris, Nikolaos Oikonomidis, Christos Maniotis, Antonios Ziakas
PURPOSE: The aim of this study was to evaluate the efficacy and safety of distal radial (DR) versus traditional radial (TR) approach during coronary angiography. METHODS: Two hundred patients scheduled to undergo transradial coronary angiography were randomized between the two approaches. Primary endpoint of the study was switching to another access site due to inability of successful target artery cannulation. Secondary endpoints were time to cannulation, total procedure duration, number of attempts, number of skin punctures and duration of manual hemostasis...
October 2, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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