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https://www.readbyqxmd.com/read/30121651/high-mobility-group-box-1-regulates-uterine-decidualization-through-bone-morphogenetic-protein-2-and-plays-a-role-in-kruppel-like-factor-5-induced-stromal-differentiation
#1
Kai Wang, Zhan-Qing Yang, Hai-Fan Yu, Yu-Si Wang, Bin Guo, Zhan-Peng Yue
BACKGROUND/AIMS: High mobility group box 1 (Hmgb1) is associated with a variety of physiological processes including embryonic development, cell proliferation and differentiation, but little information is available regarding its biological role in decidualization. METHODS: In situ hybridization, real-time PCR, RNA interference, gene overexpression and MTS assay were used to analyze the spatiotemporal expression of Hmgb1 in mouse uterus during the pre-implantation period, and explore its function and regulatory mechanisms during uterine decidualization...
August 17, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30121337/a-probabilistic-atlas-of-the-human-thalamic-nuclei-combining-ex-vivo-mri-and-histology
#2
Juan Eugenio Iglesias, Ricardo Insausti, Garikoitz Lerma-Usabiaga, Martina Bocchetta, Koen Van Leemput, Douglas N Greve, Andre van der Kouwe, Bruce Fischl, César Caballero-Gaudes, Pedro M Paz-Alonso
The human thalamus is a brain structure that comprises numerous, highly specific nuclei. Since these nuclei are known to have different functions and to be connected to different areas of the cerebral cortex, it is of great interest for the neuroimaging community to study their volume, shape and connectivity in vivo with MRI. In this study, we present a probabilistic atlas of the thalamic nuclei built using ex vivo brain MRI scans and histological data, as well as the application of the atlas to in vivo MRI segmentation...
August 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/30121220/validation-of-digital-ankle-brachial-index-as-a-screening-tool-in-symptomatic-patients-with-peripheral-arterial-disease
#3
Deepakraj Gajanana, Manisha Ganapathi Raikar, Pradhum Ram, Vikas Bhalla, Vincent Figueredo, Sean Janzer, Jon C George
INTRODUCTION: There is scarcity of data validating portable digital ankle-brachial index (ABI) with contrast angiography in peripheral arterial disease (PAD). Our aim was to provide an objective analysis of the relationship between digital ABI (dABI) and peripheral angiographic data. METHODS: Consecutive patients with symptoms of PAD between May 2014 to May 2015 at Einstein Medical Center, Philadelphia, who were undergoing simultaneous dABI and peripheral angiography, were evaluated...
June 28, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/30121201/a-novel-technique-to-assess-the-quality-of-ventilation-during-pre-hospital-cardiopulmonary-resuscitation
#4
Elisabete Aramendi, Yuanzheng Lu, Mary P Chang, Andoni Elola, Unai Irusta, Pamela Owens, Ahamed H Idris
BACKGROUND: Devices that measure ventilation in the pre-hospital setting are deficient especially during early cardiopulmonary resuscitation (CPR) before placement of an advanced airway. Consequently, evidence is limited regarding the role of ventilation during early CPR and its effect on outcomes. OBJECTIVE: To develop software that automatically identifies ventilation waveforms recorded by defibrillators based on changes in transthoracic impedance during standard CPR...
August 16, 2018: Resuscitation
https://www.readbyqxmd.com/read/30121182/perceptibility-and-acceptability-thresholds-of-simulated-facial-skin-color-differences
#5
Panagiotis Lagouvardos, Nikolina Spyropoulou, Gregory Polyzois
PURPOSE: This study investigates the perceptibility and acceptability thresholds (PT, AT) of observers for L*, a* and b* facial skin differences, very important for the fabrication of a maxillofacial prosthesis. METHODS: One image (10×13.3cm/300dpi), simulating standard facial skin color, and 27 smaller images (4.9×6.0cm/300dpi), simulating shades with different RGB values from the standard were made, using Adobe-Photoshop CS3. The RGB values, were based on 9 stepped increases in L*, a* and b*...
August 15, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/30121161/maternal-obstetric-complication-rates-remain-high-in-illinois-a-retrospective-study-2010-2015
#6
Archana Roy, Alan Peaceman, Moeun Son, Joe Feinglass
BACKGROUND: Quality measures for maternal childbirth outcomes remain controversial, although there is a consensus that maternal morbidity has been increasing in recent years. To determine whether childbirth safety has declined in Illinois, the likelihood of maternal obstetric complications was modeled by using both an established measure of severe maternal morbidity and a more expansive complication coding algorithm. METHODS: In a retrospective cohort study of 792,122 deliveries at 127 Illinois hospitals from July 2010 to September 2015, International Classification of Diseases, Ninth Revision (ICD-9) codes were used to identify Centers for Disease Control and Prevention-defined severe maternal morbidity, as well as other maternal complications defined by a route of delivery-specific algorithm originally used to evaluate the quality of obstetrics residency programs...
August 15, 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/30120987/test-retest-reliability-of-dynamic-functional-connectivity-in-resting-state-fmri
#7
Chao Zhang, Stefi A Baum, Viraj R Adduru, Bharat B Biswal, Andrew M Michael
While static functional connectivity (sFC) of resting state fMRI (rfMRI) measures the average functional connectivity (FC) over the entire rfMRI scan, dynamic FC (dFC) captures the temporal variations of FC at shorter time windows. Although numerous studies have implemented dFC analyses, only a few studies have investigated the reliability of dFC and this limits the biological interpretation of dFC. Here, we used a large cohort (N = 820) of subjects and four rfMRI scans from the Human Connectome Project to systematically explore the relationship between sFC, dFC and their test-retest reliabilities through intra-class correlation (ICC)...
August 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/30120828/toward-quantitative-three-dimensional-microvascular-networks-segmentation-with-multiview-light-sheet-fluorescence-microscopy
#8
Pol Kennel, Lise Teyssedre, Julien Colombelli, Franck Plouraboué
Three-dimensional (3-D) large-scale imaging of microvascular networks is of interest in various areas of biology and medicine related to structural, functional, developmental, and pathological issues. Light-sheet fluorescence microscopy (LSFM) techniques are rapidly spreading and are now on the way to offer operational solutions for large-scale tissue imaging. This contribution describes how reliable vessel segmentation can be handled from LSFM data in very large tissue volumes using a suitable image analysis workflow...
August 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/30120618/high-and-intensive-care-in-psychiatry-validating-the-hic-monitor-as-a-tool-for-assessing-the-quality-of-psychiatric-intensive-care-units
#9
A L van Melle, Y Voskes, H C W de Vet, J van der Meijs, C L Mulder, G A M Widdershoven
This study aims to validate the HIC monitor as a model-fidelity scale to the High and Intensive Care (HIC) model, a recently developed model for acute psychiatric wards. To assess the psychometric properties of the HIC monitor, 37 audits were held on closed inpatient wards at 20 psychiatric hospitals in the Netherlands. Interrater reliability, construct validity and content validity were examined. Our results suggest that the HIC monitor has good psychometric properties. It can be used as a tool for assessing the implementation of the HIC model on acute psychiatric wards in the Netherlands, and for quality assessment and improvement...
August 17, 2018: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/30120528/discrimination-of-human-pathogen-clostridium-species-especially-of-the-heterogeneous-c-sporogenes-and-c-botulinum-by-maldi-tof-mass-spectrometry
#10
Reiner Schaumann, Kevin Dallacker-Losensky, Christiane Rosenkranz, Gelimer H Genzel, Catalina S Stîngu, Wolfgang Schellenberger, Sebastian Schulz-Stübner, Arne C Rodloff, Klaus Eschrich
Clostridium species cause several local and systemic diseases. Conventional identification of these microorganisms is in part laborious, not always reliable, time consuming or does not always distinguish different species, i.e., C. botulinum and C. sporogenes. All in, there is a high interest to find out a reliable, powerful and rapid method to identify Clostridium spp. not only on genus but also on species level. The aim of the present study was to identify Clostridium spp. strains and also to find differences and metabolic groups of C...
August 17, 2018: Current Microbiology
https://www.readbyqxmd.com/read/30120337/preattentive-and-predictive-processing-of-visual-motion
#11
Constanze Schmitt, Steffen Klingenhoefer, Frank Bremmer
Interaction with the environment requires fast and reliable sensory processing. The visual system is confronted with a continuous flow of high-dimensional input (e.g. orientation, color, motion). From a theoretical point of view, it would be advantageous if critical information was processed independent of attentional load, i.e. preattentively. Here, we hypothesized that visual motion is such a critical signal and aimed for a neural signature of its preattentive encoding. Furthermore, we were interested in the neural correlates of predictability of linear motion trajectories based on the presence or absence of preceding motion...
August 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30119850/state-of-the-art-review-on-automated-lumen-and-adventitial-border-delineation-and-its-measurements-in-carotid-ultrasound
#12
REVIEW
P Krishna Kumar, Tadashi Araki, Jeny Rajan, John R Laird, Andrew Nicolaides, Jasjit S Suri
BACKGROUND AND OBJECTIVE: Accurate, reliable, efficient, and precise measurements of the lumen geometry of the common carotid artery (CCA) are important for (a) managing the progression/regression of atherosclerotic build-up and (b) the risk of stroke. The image-based degree of stenosis in the carotid artery and the plaque burden can be predicted using the automated carotid lumen diameter (LD)/inter-adventitial diameter (IAD) measurements from B-mode ultrasound images. The objective of this review is to present the state-of-the-art methods and systems for the measurement of LD/IAD in CCA based on automated or semi-automated strategies...
September 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/30119794/comparison-of-exophthalmos-measurements-hertel-exophthalmometer-versus-orbital-parameters-in-2-dimensional-computed-tomography
#13
Kyung Jun Choi, Min Joung Lee
OBJECTIVE: To compare the reliability of orbital parameters calculated using 2-dimensional computed tomography (CT) and Hertel exophthalmometry when measuring exophthalmos in normal subjects and in patients with thyroid-associated orbitopathy (TAO). DESIGN: Retrospective, observational case series. PARTICIPANTS: CT images of 33 normal orbits and 69 orbits with TAO were included. METHODS: In central axial CT scans, globe area (GA), orbital area (OA), and GA/OA ratio were calculated by 2 observers using ImageJ...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/30119618/single-center-experience-with-liver-transplant-using-donors-with-very-high-transaminase-levels
#14
Paulo N Martins, Amanda Rawson, Babak Movahedi, Isabel M A Brüggenwirth, Natasha H Dolgin, Ann-Britt Martins, Paria Mahboub, Adel Bozorgzadeh
OBJECTIVES: Elevation of transaminases has been used as a marker of hepatic ischemic injury and as a crucial parameter for liver graft assessment. However, analysis of serum transaminases has limitations regarding the quantitative assessment of liver necrosis and is not a reliable predictor of outcomes. MATERIALS AND METHODS: We retrospectively reviewed the medical records of all liver transplants (N = 238) performed at the UMass Memorial Medical Center from 2009 to 2013...
August 17, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/30119552/position-deviation-compensation-demodulation-method-for-multi-channel-polarized-low-coherence-interferometry
#15
Shuang Wang, Jinshi Zhang, Junfeng Jiang, Kun Liu, Xue Wang, Xuezhi Zhang, Zhiyang Wu, Jie Zhou, Hai Xiao, Tiegen Liu
A position-deviation-compensation demodulation method is proposed to improve the channel adaptability of Fabry-Perot (F-P) sensor in a multi-channel optical fiber F-P sensing system. By combining the envelope peak position (EPP) retrieval process and the position compensation process, the proposed method enables the accurate demodulation of F-P sensors in all channels. Thereinto, the EPP retrieval process uses the phase information to recover the EPP with high precision; the position compensation process compensates the position deviation by an optical-path-based model, which is established to illustrate the principle of the position deviation between different channels...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30119358/characterization-and-generation-of-high-power-multi-axis-vortex-beams-by-using-off-axis-pumped-degenerate-cavities-with-external-astigmatic-mode-converter
#16
P H Tuan, Y H Hsieh, Y H Lai, K F Huang, Y F Chen
The generalized geometric mode with several high-order Hermite-Gaussian (HG) beams localized on ray periodic orbits in the degenerate resonator is generated by an off-axis pumped Nd:YVO4 laser, by performing beam transformation via an astigmatic mode converter, the generalized geometric modes are found that can be converted into the multi-axis vortex beams with the bundled-rings structures. Experimental results reveal that the generated multi-axis vortex beams can preserve quite stable beam structures even under high-power operation...
August 6, 2018: Optics Express
https://www.readbyqxmd.com/read/30119023/simple-and-fast-method-for-the-measurement-of-legacy-and-novel-brominated-flame-retardants-in-human-serum
#17
Catherine Pirard, Corinne Charlier
Recent and reliable human biomonitoring data on brominated flame retardants (BFRs), either legacy or new BFRs, are still needed to assess human exposure. The aim of this work was therefore to develop and validate an accurate, fast and user-friendly analytical strategy for the determination of 15 legacy and novel BFRs in human serum namely 8 polybrominated diphenylethers (BDE-28, -47, -99, -100, -153, -154, -183, and -209), 1 hexabromobiphenyl (PBB-153), and 6 novel BFRs (pentabromotoluene, hexabromobenzene, pentabromoethylbenzene, 2-ethylhexy-2,3,4,5-tetrabromobenzoate, 1,2-bis(2,4,6-tribromophenoxy)ethane, and decabromodiphenylethane)...
August 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/30118685/presbyopia-and-ocular-conditions-causing-near-vision-impairment-in-older-adults-from-the-brazilian-amazon-region
#18
Cristina Coimbra Cunha, Adriana Berezovsky, João Marcello Furtado, Nívea Nunes Ferraz, Arthur Gustavo Fernandes, Sergio Muñoz, Sung Song Watanabe, Paula Yuri Sacai, Marcela Cypel, Márcia Higashi Mitsuhiro, Paulo Henrique Morales, Galton Carvalho Vasconcelos, Marcos Jacob Cohen, Mauro Campos, Jacob Moysés Cohen, Rubens Belfort, Solange Rios Salomão
PURPOSE: To investigate the prevalence and causes of near vision impairment in a population of older adults from the Brazilian Amazon Region. DESIGN: Population-based cross-sectional study. METHODS: Cluster sampling was used in randomly selecting subjects 45 years of age and older from urban and rural areas of Parintins city, Brazil. Participants underwent ophthalmic examination, including uncorrected (UCNVA), presenting (PNVA) and best-corrected near visual acuity (BCNVA) from each eye, biomicroscopy, fundoscopy and subjective refraction including testing with additional lenses for near vision optical correction...
August 14, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30118581/harnessing-the-minion-an-example-of-how-to-establish-long-read-sequencing-in-a-laboratory-using-challenging-plant-tissue-from-eucalyptus-pauciflora
#19
Miriam Schalamun, Ramawatar Nagar, David Kainer, Eleanor Beavan, David Eccles, John P Rathjen, Robert Lanfear, Benjamin Schwessinger
Long-read sequencing technologies are transforming our ability to assemble highly complex genomes. Realising their full potential is critically reliant on extracting high quality, high molecular weight (HMW) DNA from the organisms of interest. This is especially the case for the portable MinION sequencer which enables all laboratories to undertake their own genome sequencing projects, due to its low entry cost and minimal spatial footprint. One challenge of the MinION is that each group has to independently establish effective protocols for using the instrument, which can be time consuming and costly...
August 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/30118543/electroluminescent-devices-based-on-2d-semiconducting-transition-metal-dichalcogenides
#20
REVIEW
Junyong Wang, Ivan Verzhbitskiy, Goki Eda
Ultrathin layers of van der Waals inorganic semiconductors represent a new class of excitonic materials with attractive light-emitting properties. Recent observation of valley polarization, optically pumped lasing, exciton-polaritons, and single-photon emission highlights the exciting prospects for two-dimensional (2D) semiconductors for applications in novel photonic devices. Development of efficient and reliable light sources based on excitonic electroluminescence in 2D semiconductors is of fundamental importance toward the practical implementation of photonic devices...
August 17, 2018: Advanced Materials
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