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https://www.readbyqxmd.com/read/30547407/stability-in-grn-inference
#1
Giuseppe Jurman, Michele Filosi, Roberto Visintainer, Samantha Riccadonna, Cesare Furlanello
Reconstructing a gene regulatory network from one or more sets of omics measurements has been a major task of computational biology in the last 20 years. Despite an overwhelming number of algorithms proposed to solve the network inference problem either in the general scenario or in an ad-hoc tailored situation, assessing the stability of reconstruction is still an uncharted territory and exploratory studies mainly tackled theoretical aspects. We introduce here empirical stability, which is induced by variability of reconstruction as a function of data subsampling...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30547253/a-systematic-review-of-current-methodology-of-high-resolution-pharyngeal-manometry-with-and-without-impedance
#2
REVIEW
Katharina Winiker, Anna Gillman, Esther Guiu Hernandez, Maggie-Lee Huckabee, Kristin Gozdzikowska
PURPOSE: This systematic review appraises and summaries methodology documented in studies using high resolution pharyngeal manometry (HRM) with and without impedance technology (HRIM) in adult populations. METHODS: Four electronic databases CINAHL, EMBASE, MEDLINE, and Cochrane Library were searched up to, and including March 2017. Studies reporting pharyngeal HRM/HRIM for swallowing and/or phonatory assessment, published in peer-reviewed journals in English, German, or Spanish were assessed for the inclusion criteria...
December 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30547185/breaking-the-curse-of-dimensionality-to-identify-causal-variants-in-breeding-4
#3
REVIEW
Guillaume P Ramstein, Sarah E Jensen, Edward S Buckler
In the past, plant breeding has undergone three major transformations and is currently transitioning to a new technological phase, Breeding 4. This phase is characterized by the development of methods for biological design of plant varieties, including transformation and gene editing techniques directed toward causal loci. The application of such technologies will require to reliably estimate the effect of loci in plant genomes by avoiding the situation where the number of loci assayed (p) surpasses the number of plant genotypes (n)...
December 13, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/30547176/a-translational-approach-to-assess-the-metabolomic-impact-of-stabilized-gold-nanoparticles-by-nmr-spectroscopy
#4
José Raul Herance, Hermenegildo García, Patricia Gutiérrez-Carcedo, Sergio Navalón, Antonio Pineda-Lucena, Martina Palomino-Schätzlein
Gold nanoparticles have high potential in the biomedical area, especially in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. To this end, in this study, we apply an experimental approach based on nuclear magnetic resonance spectroscopy to study the effect of gold nanoparticles, stabilised with cerium oxide or chitosan, on a human cancer cell model...
December 14, 2018: Analyst
https://www.readbyqxmd.com/read/30547158/energy-dispersive-x-ray-fluorescence-zn-fe-ratiometric-determination-of-zinc-levels-in-expressed-prostatic-fluid-a-direct-non-invasive-and-highly-accurate-screening-for-prostate-cancer
#5
Leslie C Costello, Renty B Franklin
Prostate specific antigen (PSA) does not provide the reliability that is required for the accurate urology screening of prostate cancer (PCa). Consequently, there has been a major focus and search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the urology screening for prostate cancer. Virtually all PCa cases exhibit a marked decrease in zinc in prostate tissue and in prostatic fluid. This is a hallmark "signature" clinical characteristic for all prostate cancers, which provides the clinical basis for zinc screening of PCa...
November 2018: Acta Sci Cancer Biol
https://www.readbyqxmd.com/read/30547045/patient-derived-xenograft-model-for-uterine-leiomyoma-by-sub-renal-capsule-grafting
#6
Vanida Ann Serna, Takeshi Kurita
Uterine leiomyoma (UL) or fibroid is a benign smooth muscle tumor of the myometrium with a lifetime incidence of approximately 70%. ULs often require medical intervention due to severe symptoms such as heavy menstrual bleeding and abdominal pain. Although the most common and effective management of ULs is surgical removal, the invasive surgical procedure imposes physical and psychological burdens on the patients. Moreover, the economic burden of UL on health care system is enormous due to the high cost of surgeries...
2018: Journal of Biological Methods
https://www.readbyqxmd.com/read/30547025/ideal-cardiovascular-health-and-cognitive-test-performance-testing-a-modified-index-of-life-s-simple-7-among-older-chinese-adults
#7
Theresa E Gildner, Nawi Ng, Fan Wu, Yanfei Guo, J Josh Snodgrass, Paul Kowal
Evidence suggests that cognitive decline in older adults is influenced by cardiovascular health (CVH), with metabolic and vascular mechanisms hypothesized to underlie the etiology of cognitive impairment. Research in high-income nations suggests that improved CVH is linked with decreased cognitive impairment risk, but it is unclear if this pattern is evident in low-income countries. Nationally-representative data collected in China were drawn from the World Health Organization's Study on global AGing and adult health Wave 1 (2007-2010; n = 11,295)...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/30547019/effect-of-different-surface-treatments-and-bonding-modalities-on-the-shear-bond-strength-between-metallic-orthodontic-brackets-and-glazed-monolithic-zirconia-crowns
#8
Jamal Y Amer, Mohammad M Rayyan
OBJECTIVE: To evaluate the effect of different surface treatments and bonding modalities on the shear bond strength (SBS) between metallic orthodontic brackets and zirconia crowns. MATERIALS AND METHODS: Sixty zirconia specimens were computer-aided design/computer-aided manufacturing milled, sintered, glazed, and embedded in acrylic resin. The specimens were divided into three groups according to the surface treatment applied: C: no surface treatment (control), S: sandblasted with 50 μm Al2 O3 , and D: Sof-Lex disc roughening...
2018: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/30547016/effect-of-the-application-of-high-frequency-mechanical-vibration-on-tooth-length-concurrent-with-orthodontic-treatment-using-clear-aligners-a-retrospective-study
#9
Khaled Farouk, Thoas Shipley, Tarek El-Bialy
OBJECTIVES: To evaluate the possible change in teeth lengths as an indicator of orthodontically induced tooth root resorption (OITRR) after high-frequency mechanical vibration (HFV) treatment concurrent with Invisalign Smart Track® aligners as evaluated by cone beam computed tomography (CBCT). MATERIALS AND METHODS: The sample, composed of 30 patients with an average age of 26 ± 11 years and Class I malocclusion with an initial anterior crowding ranging from 3 to 5 mm, was divided equally into two groups; Group I received adjunctive high-frequency mechanical vibration (HFV); Group II, the control, did not receive adjunctive mechanical treatment...
2018: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/30546008/immune-checkpoint-inhibitors-recent-progress-and-potential-biomarkers
#10
REVIEW
Pramod Darvin, Salman M Toor, Varun Sasidharan Nair, Eyad Elkord
Cancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an immense breakthrough in cancer therapeutics. Among the immune checkpoint inhibitors, PD-1/PD-L1 and CTLA-4 inhibitors showed promising therapeutic outcomes, and some have been approved for certain cancer treatments, while others are under clinical trials. Recent reports have shown that patients with various malignancies benefit from immune checkpoint inhibitor treatment...
December 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/30545839/clinical-feasibility-of-zero-te-skull-mri-in-patients-with-head-trauma-in-comparison-with-ct-a-single-center-study
#11
S B Cho, H J Baek, K H Ryu, B H Choi, J I Moon, T B Kim, S K Kim, H Park, M J Hwang
BACKGROUND AND PURPOSE: Conventional MR imaging techniques cannot produce optimal images of bone structures because bone has little water and a very short T2 life span. The aim of this study was to investigate the clinical feasibility of skull MR imaging using the zero TE sequence in patients with head trauma by assessing its diagnostic image quality and quantitative measurement compared with CT images. MATERIALS AND METHODS: Thirteen enrolled patients with head trauma were assessed using brain CT and skull MR imaging...
December 13, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/30545601/the-cortical-face-network-of-the-prosopagnosic-patient-ps-with-fast-periodic-stimulation-in-fmri
#12
Xiaoqing Gao, Quoc C Vuong, Bruno Rossion
Following brain damage, the patient PS suffers from selective impairment in recognizing individuals by their faces, i.e., prosopagnosia. Her case has been documented in more than 30 publications to date, informing about the nature of individual face recognition and its neural basis. Here we report new functional neuroimaging data obtained on PS with a recently developed fast periodic stimulation functional imaging (FPS-fMRI) paradigm combining high sensitivity, specificity and reliability in identifying the cortical face-selective network (Gao et al...
November 17, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/30545397/whole-exon-sequencing-of-human-myeloma-cell-lines-shows-mutations-related-to-myeloma-patients-at-relapse-with-major-hits-in-the-dna-regulation-and-repair-pathways
#13
Benoît Tessoulin, Agnès Moreau-Aubry, Géraldine Descamps, Patricia Gomez-Bougie, Sophie Maïga, Alban Gaignard, David Chiron, Emmanuelle Ménoret, Steven Le Gouill, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck
BACKGROUND: Human myeloma cell lines (HMCLs) are widely used for their representation of primary myeloma cells because they cover patient diversity, although not fully. Their genetic background is mostly undiscovered, and no comprehensive study has ever been conducted in order to reveal those details. METHODS: We performed whole-exon sequencing of 33 HMCLs, which were established over the last 50 years in 12 laboratories. Gene expression profiling and drug testing for the 33 HMCLs are also provided and correlated to exon-sequencing findings...
December 13, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/30545318/development-and-validation-of-a-screener-based-on-interrai-assessments-to-measure-informal-caregiver-wellbeing-in-the-community
#14
Raquel S D Betini, John P Hirdes, Nancy Curtin-Telegdi, Lisa Gammage, Jennifer Vansickle, Jeff Poss, George Heckman
BACKGROUND: Informal caregivers are invaluable partners of the health care system. However, their caring responsibilities often affect their psychological wellbeing and ability to continue in their role. It is of paramount importance to easily identify caregivers that would benefit from immediate assistance. METHODS: In this nonexperimental cohort study, a cross-sectional analysis was conducted among 362 informal caregivers (mean age 64.1 years, SD ± 13.1) caring for persons with high care needs (mean age 78...
December 13, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/30545274/cross-cultural-adaptation-and-validation-of-the-finnish-version-of-the-michigan-hand-outcomes-questionnaire
#15
S Hulkkonen, J P Repo, A Häkkinen, J Karppinen, J Ryhänen
BACKGROUND AND AIMS: Michigan Hand Outcomes Questionnaire is a widely used patient-reported outcome measure in hand surgery. The aim of this study was to translate and validate the Michigan Hand Outcomes Questionnaire into Finnish for Finnish patients with hand problems following international standards and guidelines. MATERIAL AND METHODS: The original English Michigan Hand Outcomes Questionnaire was translated into Finnish. Altogether, 115 patients completed the Finnish Michigan Hand Outcomes Questionnaire, and reference outcomes: Disabilities of the Arm and Shoulder, EQ-5D 3L and pain intensity on a visual analog scale...
December 13, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/30545143/heat-resistant-microporous-ag-die-attach-structure-for-wide-band-gap-power-semiconductors
#16
Seungjun Noh, Hao Zhang, Katsuaki Suganuma
In this work, efforts were made to prepare a thermostable die-attach structure which includes stable sintered microporous Ag and multi-layer surface metallization. Silicon carbide particles (SiCp ) were added into the Ag sinter joining paste to improve the high-temperature reliability of the sintered Ag joints. The use of SiCp in the bonding structures prevented the morphological evolution of the microporous structure and maintained a stable structure after high temperature storage (HTS) tests, which reduces the risk of void formation and metallization dewetting...
December 12, 2018: Materials
https://www.readbyqxmd.com/read/30545088/rvfv-infection-in-goats-by-different-routes-of-inoculation
#17
Andrea L Kroeker, Valerie Smid, Carissa Embury-Hyatt, Estella Moffat, Brad Collignon, Oliver Lung, Robbin Lindsay, Hana Weingartl
Rift Valley fever virus (RVFV) is a zoonotic arbovirus of the Phenuiviridae family. Infection causes abortions in pregnant animals, high mortality in neonate animals, and mild to severe symptoms in both people and animals. There is currently an ongoing effort to produce safe and efficacious veterinary vaccines against RVFV in livestock to protect against both primary infection in animals and zoonotic infections in people. To test the efficacy of these vaccines, it is essential to have a reliable challenge model in relevant target species, including ruminants...
December 12, 2018: Viruses
https://www.readbyqxmd.com/read/30545039/effect-of-road-safety-education-on-road-risky-behaviors-of-spanish-children-and-adolescents-findings-from-a-national-study
#18
Francisco Alonso, Cristina Esteban, Sergio Useche, Natura Colomer
BACKGROUND: Road Safety Education (RSE) is widely known as a reliable determinant of the future results for what concerns health and welfare and as an undisputable factor which contributes to the social behavior of individuals and to their mid- and long-term road safety outcomes. However, its development has been relatively scarce in most countries, a fact which has contributed to letting matters as delicate as traffic crashes, largely explained by road misbehaviors, continue to be a prevalent problem, thus affecting the health of the community...
December 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30545009/lane-endpoint-detection-and-position-accuracy-evaluation-for-sensor-fusion-based-vehicle-localization-on-highways
#19
Eun Seok Jang, Jae Kyu Suhr, Ho Gi Jung
Landmark-based vehicle localization is a key component of both autonomous driving and advanced driver assistance systems (ADAS). Previously used landmarks in highways such as lane markings lack information on longitudinal positions. To address this problem, lane endpoints can be used as landmarks. This paper proposes two essential components when using lane endpoints as landmarks: lane endpoint detection and its accuracy evaluation. First, it proposes a method to efficiently detect lane endpoints using a monocular forward-looking camera, which is the most widely installed perception sensor...
December 11, 2018: Sensors
https://www.readbyqxmd.com/read/30544998/reducing-message-collisions-in-sensing-based-semi-persistent-scheduling-sps-by-using-reselection-lookaheads-in-cellular-v2x
#20
Yongseok Jeon, Seungho Kuk, Hyogon Kim
In the C-V2X sidelink Mode 4 communication, the sensing-based semi-persistent scheduling (SPS) implements a message collision avoidance algorithm to cope with the undesirable effects of wireless channel congestion. Still, the current standard mechanism produces a high number of packet collisions, which may hinder the high-reliability communications required in future C-V2X applications such as autonomous driving. In this paper, we show that by drastically reducing the uncertainties in the choice of the resource to use for SPS, we can significantly reduce the message collisions in the C-V2X sidelink Mode 4...
December 11, 2018: Sensors
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