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Metabolic syndrome in children

Leena Antikainen, Jarmo Jääskeläinen, Henrikki Nordman, Raimo Voutilainen, Hanna Huopio
BACKGROUND: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children's height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. METHODS: A cohort of 135 prepubertal Caucasian children (age range 4.4-9.7 years) was studied in a controlled cross-sectional study...
August 15, 2018: Hormone Research in Pædiatrics
Marko Kostovski, Zoran Gucev, Velibor Tasic, Momir Polenakovic
No abstract text is available yet for this article.
July 1, 2018: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Phalakorn Suebsamran, Taksin Pimpak, Patnapa Thani, Parinya Chamnan
BACKGROUND: Although metabolic syndrome (MetS) has become a significant public health problem worldwide, little evidence exists to describe the prevalence of MetS in school children using MetS different classifications, and its association with health-related behaviors. METHODS: Using data on 393 children and adolescents aged 13-16 years participating in the Ubon Ratchathani Metabolic Syndrome in Adolescent (UMeSIA) Project, the prevalence of MetS was determined using the International Diabetes Federation (IDF) 2007 definition and other three classifications reported in the previous literature...
August 14, 2018: Metabolic Syndrome and related Disorders
Lide Arenaza, Victoria Muñoz-Hernández, María Medrano, Maddi Oses, Maria Amasene, Elisa Merchán-Ramírez, Cristina Cadenas-Sanchez, Francisco B Ortega, Jonatan R Ruiz, Idoia Labayen
There is a general belief that having breakfast is an important healthy lifestyle factor; however, there is scarce evidence on the influence of breakfast quality and energy density on cardiometabolic risk in children, as well as on the role of physical activity in this association. The aims of this paper were (i) to examine the associations of breakfast quality and energy density from both solids and beverages with cardiometabolic risk factors, and (ii) to explore whether physical activity levels may attenuate these relationships in children with overweight/obesity from two projects carried out in the north and south of Spain...
August 10, 2018: Nutrients
Kunjal Patel, Jane Lindsey, Konstantia Angelidou, Grace Aldrovandi, Paul Palumbo
OBJECTIVE: To estimate the long-term metabolic effects of initiating a lopinavir/ritonavir (LPV/r)-based regimen as first-line therapy for HIV-infected children less than three years of age in resource-limited settings. DESIGN: Prospective cohort study after conclusion of the P1060 randomized clinical trials ( Identifier: NCT00307151), with an overall follow-up of seven years. METHODS: Longitudinal total cholesterol and triglyceride measures were compared between 222 and 227 children randomized to initiate LPV/r- and NVP-based regimens respectively...
August 9, 2018: AIDS
Marijke De Keukelaere, Steffen Fieuws, Nele Reynaert, Eva Vandoorne, Kristel Vande Kerckhove, Willeke Asscherickx, Kristina Casteels
The prevalence of childhood overweight and obesity has risen during the last 30 years, not only in children with type 2 diabetes, but also those with type 1 (T1D) and this is linked with an increased cardiovascular risk. A better understanding of weight patterns in the years after diagnosis of T1D is important to identify those children with a risk for excess weight gain and strategies to decrease this. We retrospectively analyzed data of all children with T1D followed at the department of Pediatric Endocrinology Leuven and diagnosed between 1991 and 2015...
August 9, 2018: European Journal of Pediatrics
Anmol Gupta, Amit Sachdeva, Narender Mahajan, Aakriti Gupta, Neha Sareen, Ravindra Mohan Pandey, Lakshmy Ramakrishnan, Hem Chandra Sati, Brij Sharma, Neetu Sharma, Umesh Kapil
Introduction: Recently, an increasing trend in the prevalence of pediatric metabolic syndrome (PMS) among school-age children has been documented in different parts of India. There is lack of data on the prevalence of PMS and its associated risk factors among school-age children living in district Shimla, Himachal Pradesh. Hence, to fill in the gap in the existing knowledge, the present study was conducted. Methodology: A cross-sectional study was conducted during 2015-2016...
May 2018: Indian Journal of Endocrinology and Metabolism
Ramiro Marx Alves Cortez, Ana Míria de Oliveira Batista, Mariana Rodrigues da Rocha, Isa Moema de Sales Santos, Jayne Ramos Araújo Moura, Ana Roberta Vilarouca da Silva
OBJECTIVE: To analyze the knowledge of children and adolescents about risk factors for metabolic syndrome (MS) before and after educational interventions. METHOD: A quasi-experimental, comparative, prospective and intervention study conducted in 2015 and 2016 with 43 students in the city of Picos (state of Piauí-PI). Five health education meetings were held. For the knowledge analysis, was applied a questionnaire at three different moments. RESULTS: Participants' mean age was 12...
2018: Revista Brasileira de Enfermagem
Eloïse Giabicani, Aurélie Pham, Frédéric Brioude, Delphine Mitanchez, Irène Netchine
Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or vascular troubles and their potential interaction. The physiopathology of FGR is not yet fully elucidated, but the insulin-like growth factor system is known to play a central role. Specific clinical features can lead to the identification of genetic syndromes in some patients. FGR leads to multiple global health concerns, from the perinatal period, with higher morbidity/mortality, through infancy, with neurodevelopmental, growth, and metabolic issues, to the onset of puberty and later in life, with subfertility and elevated risks of cardiovascular and kidney diseases...
August 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
Juliane Léger, Jean Claude Carel
Hyperthyroidism in children is a rare heterogeneous syndrome characterized by excessive thyroid hormone production. Its manifestations differ according to disease severity. For all forms of hyperthyroidism, treatment aims to restore a euthyroid state, enabling the child to demonstrate appropriate metabolism, growth, and neurocognitive development. Graves' disease is the most frequent cause of hyperthyroidism in children. Treatment modalities include antithyroid drugs, with the advantage that prolonged treatment for several years can be followed by freedom from medical intervention in about 40-50% of cases...
August 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
Lefeng Zhang, Yongqiang Jin, Fuqiang Zhang, Hongyin Li, Qingyu Wu
BACKGROUND: Acute kidney injury (AKI) is one of the common complications in infants and children after complex congenital heart surgery. Peritoneal dialysis (PD) is usually applied for renal replacement therapy (RRT), especially in infants. We investigated the efficacy and safety of modified PD for the treatment of acute renal failure and congestive heart failure after cardiac surgery for congenital heart disease in infants. METHODS: We retrospectively analyzed five consecutive patients from October 2015 to February 2017...
June 25, 2018: Heart Surgery Forum
Alexandra Lind, Jovanna Dahlgren, Lina Raffa, Kerstin Allvin, Deala Ghazi Mroué, Marita Andersson Grönlund
PURPOSE: To study visual function and ocular fundus morphology in relation to growth, metabolic status and blood pressure in moderate-to-late preterm (MLP) children at 10 years of age. DESIGN: Prospective cohort study. METHODS: In this population-based observational study, non-syndromic MLP children born in Gothenburg, Sweden, were examined neonatally year 2002-2003 concerning length, weight, head circumference and insulin-like growth factor I (IGF-I)...
August 3, 2018: American Journal of Ophthalmology
Tareq Al-Ayed, Naveed Ur Rahman, Abdullah Alturki, Fahad Aljofan
BACKGROUND: Continuous renal replacement therapy (CRRT) has become the preferred mode of dialysis to support critically ill children with acute kidney injury. However, there are limited pediatric data on CRRT use, especially in our region. OBJECTIVE: Determine the outcome of CRRT among critically ill children. DESIGN: Retrospective cohort study. SETTING: Pediatric intensive care unit. PATIENTS AND METHODS: The study included critically ill children 1-14 years of age who underwent CRRT from July 2009 to June 2015...
July 2018: Annals of Saudi Medicine
Arif O Khan, Nisha Patel, Nicola G Ghazi, Shahad S Alzahrani, Stefan T Arold, Fowzan S Alkuraya
PURPOSE: The purpose of this study is to uncover the genetic cause for non-syndromic macular "coloboma" (pseudocoloboma) in three brothers from a consanguineous family. METHODS: Homozygosity mapping for the three affected brothers and whole-exome sequencing in one affected brother, followed by confirmatory Sanger sequencing and segregation analysis of the candidate gene for all immediate family members; molecular modeling of the candidate mutation; and review of clinical, imaging, and laboratory findings...
August 1, 2018: Ophthalmic Genetics
Marinos Kontzialis, Thierry A G M Huisman
There are multiple causes of neurotoxicity in children including medications, extrinsic toxins and insults, illicit drugs, built up of toxic metabolites due to genetic or acquired disorders, and metabolic abnormalities. The review is centered on causes of neurotoxicity affecting the pediatric brain and producing typical and easily recognized imaging manifestations. Early identification of common and less common imaging findings may point toward the correct direction, and may facilitate early diagnosis and institution of appropriate treatment to reverse or at least limit the injury to the developing brain...
July 31, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Adriana Cherskov, Alexa Pohl, Carrie Allison, Heping Zhang, Rupert A Payne, Simon Baron-Cohen
Elevated levels of prenatal testosterone may increase the risk for autism spectrum conditions (autism). Given that polycystic ovary syndrome (PCOS) is also associated with elevated prenatal testosterone and its precursor sex steroids, a hypothesis from the prenatal sex steroid theory is that women with PCOS should have elevated autistic traits and a higher rate of autism among their children. Using electronic health records obtained from the Clinical Practice Research Datalink (CPRD) in the UK between 1990 and 2014, we conducted three matched case-control studies...
August 1, 2018: Translational Psychiatry
Volkan Okur, Shannon Nees, Wendy K Chung, Usha Krishnan
Kleefstra Syndrome is a rare genetic disorder caused by mutations in EHMT1, Euchromatin Histone Methyl Transferase 1, or deletions encompassing EHMT1 on 9q34.3. Congenital heart defects are among the major findings in patients with 9q34.3 microdeletion/Kleefstra Syndrome along with recognizable facial appearance, developmental delay/intellectual disability including severely delayed or absent speech, hypotonia, seizures, behavioral and sleep abnormalities. Pulmonary hypertension (PH) is a rare condition associated with increased pulmonary artery and right heart pressures that can lead to right heart failure and death if untreated...
July 31, 2018: American Journal of Medical Genetics. Part A
Gamze Kaya, Zehra Yavas Abali, Firdevs Bas, Sukran Poyrazoglu, Feyza Darendeliler
The aim of this study was to analyze the relationship between premature adrenarche (PA) and metabolic syndrome (MeS) parameters at presentation and during puberty. This study comprised 47 girls with PA. Age- and puberty-matched 22 healthy girls without PA were the control group. Patients were evaluated at admission (first evaluation) and later in puberty (second evaluation). Anthropometric measurements, lipid levels, and hormonal parameters were studied and oral glucose tolerance test was performed. Indices for insulin resistance (IR) were calculated...
July 28, 2018: European Journal of Pediatrics
Maryam Barzin, Shayan Aryannezhad, Sara Serahati, Akram Beikyazdi, Fereidoun Azizi, Majid Valizadeh, Maryam Ziadlou, Farhad Hosseinpanah
BACKGROUND: Childhood obesity is one of the most challenging public health issues of twenty-first century. While we know that there is an increase in prevalence of childhood and adolescence obesity, incidence studies must be carried out. The main objective of this study was to determine childhood obesity incidence and its potential predictors in Tehranian urban population. METHODS: This study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS), addressing incidence and risk factors of obesity throughout several phases from 1999-2001 to 2009-2011 among Tehranian urban population...
July 25, 2018: BMC Pediatrics
Jerrold J Heindel, Bruce Blumberg
Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure. However, numerous other factors are important in the etiology of obesity. The obesogen hypothesis proposes that environmental chemicals termed obesogens promote obesity by acting to increase adipocyte commitment, differentiation, and size by altering metabolic set points or altering the hormonal regulation of appetite and satiety...
July 25, 2018: Annual Review of Pharmacology and Toxicology
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