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Anti IL-5

Ahmed Al-Dwairi, Mohammad Alqudah, Othman Al-Shboul, Mahmoud Alfaqih, Dana Alomari
Inflammatory bowel disease (IBD) is a chronic incurable condition characterized by relapsing inflammation of the gut. Intestinal smooth muscle cells (SMCs) are affected structurally and functionally during IBD due to excessive production of different inflammatory mediators. Metformin is a widely used antidiabetic agent known to exert several anti-inflammatory effects in different tissues independently from its hypoglycemic effect. The aim of the present study was to investigate the effect of metformin on expression and secretion of different cytokines and chemokines from mouse colon SMCs (CSMCs) following induction of inflammation with lipopolysaccharide (LPS) in vitro ...
August 2018: Experimental and Therapeutic Medicine
Andrea Matucci, Alessandra Vultaggio, Romano Danesi
BACKGROUND: Monoclonal antibodies (mAbs) approved for use as add-on therapy in patients with severe asthma target the underlying pathogenesis of asthma. MAIN BODY: Omalizumab binds immunoglobulin E (IgE), thereby inhibiting its interaction with the high-affinity IgE receptor and reducing the quantity of free IgE available to trigger the allergic cascade. Anti-interleukin (IL)-5 mAbs mepolizumab, benralizumab and reslizumab block the interaction between IL-5 and its receptor on eosinophils, thus targeting the eosinophilic pathway in asthma...
August 16, 2018: Respiratory Research
Magdalena Timoszuk, Katarzyna Bielawska, Elżbieta Skrzydlewska
Evening primrose ( Oenothera L.) is a plant belonging to the family Onagraceae, in which the most numerous species is Oenothera biennis . Some plants belonging to the genus Oenothera L. are characterized by biological activity. Therefore, studies were conducted to determine the dependence of biological activity on the chemical composition of various parts of the evening primrose, mainly leaves, stems, and seeds. Common components of all parts of the Oenothera biennis plants are fatty acids, phenolic acids, and flavonoids...
August 14, 2018: Antioxidants (Basel, Switzerland)
Vanessa Gama Goulart, Grasielle Duarte Menezes, Sheila Espírito-Santo, Adriana da Cunha Faria-Melibeu, Claudio Alberto Serfaty, Paula Campello-Costa
OBJECTIVE: Interleukin 4 (IL-4) is an anti-inflammatory cytokine related to different aspects of central nervous system development such as survival, proliferation, and differentiation, among others. Our goals were to investigate the effect of intravitreous treatment with IL-4 on the activation of downstream signaling pathways in the retina and the distribution of retinal axons within the superior colliculus (SC). MATERIAL AND METHODS: Lister hooded rats were submitted to an intravitreous injection of either IL-4 (5 U/µL) or PBS (vehicle) at postnatal day 10 (PND10)...
August 15, 2018: Neuroimmunomodulation
Karolina Pawłowska, Monika E Czerwińska, Marcin Wilczek, Jakub Strawa, Michał Tomczyk, Sebastian Granica
The isolation of phenolics from aerial parts of Corispermum marschallii yielded a total of 13 compounds including nine previously undescribed patuletin and spinacetin glycosides. These were identified as patuletin 3- O-β-d-galactopyranosyl-7- O-β-d-glucopyranoside (1), spinacetin 3- O-β-d-galactopyranosyl-7- O-β-d-glucopyranoside (2), patuletin 3- O-(6″- O-β-d-glucopyranosyl)-β-d-galactopyranoside (3), patuletin 3- O-(6″- O-α-l-arabinopyranosyl)-β-d-galactopyranoside (4), patuletin 3- O-(2″- O-(5‴- O-α-l-arabinopyranosyl)-β-d-apiofuranosyl)-β-d-galactopyranoside (5), patuletin 3- O-(2″- O-β-d-apiofuranosyl)-β-d-galactopyranoside (6), spinacetin 3- O-β-d-galactopyranoside (7), patuletin 3- O-β-d-galactopyranosyl-7- O-(6‴- O-feruloyl)-β-d-glucopyranoside (8), and spinacetin 3- O-β-d-galactopyranosyl-7- O-(6‴- O-feruloyl)-β-d-glucopyranoside (9)...
August 15, 2018: Journal of Natural Products
Hae Min So, Hee Jeong Eom, Dahae Lee, Sil Kim, Ki Sung Kang, Il Kyun Lee, Kwan-Hyuck Baek, Jun Yeon Park, Ki Hyun Kim
Identification of bioactive natural products with anticancer activity as well as alleviating effects on chemotherapy-induced side effects has significant implications for cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has been used in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B...
August 14, 2018: Archives of Pharmacal Research
A B Spejo, G B Chiarotto, A D F Ferreira, D A Gomes, R S Ferreira, B Barraviera, A L R Oliveira
BACKGROUND: Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors to lesioned neurons. METHODS: Lewis adult female rats were submitted to a unilateral ventral funiculus cut at the spinal levels L4, L5, and L6. The animals were divided into the following groups: IA (intramedullary axotomy), IA + DMEM (Dulbecco's modified Eagle's medium), IA + FS (fibrin sealant), IA + MSC (106 cells), and IA + FS + MSC (106 cells)...
August 14, 2018: Journal of Neuroinflammation
José Ignacio Veytia-Bucheli, Juana María Jiménez-Vargas, Erika Isabel Melchy-Pérez, Monserrat Alba Sandoval-Hernández, Lourival Domingos Possani, Yvonne Rosenstein
BACKGROUND: In T cells, the Kv 1.3 and the KCa 3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during TEM cell activation, the number of Kv 1.3 channels on the cell membrane dramatically increases. Kv 1.3 blockade results in inhibition of Ca2+ signaling in TEM cells, thus eliciting an immunomodulatory effect. Among the naturally occurring peptides, the Vm24 toxin from the Mexican scorpion Vaejovis mexicanus is the most potent and selective Kv 1...
August 14, 2018: Cell Communication and Signaling: CCS
Lin Wei, Yang Yang, Yandong Zhou, Min Li, Hailong Yang, Lixian Mu, Qian Qian, Jing Wu, Wei Xu
BACKGROUND: Mosquitoes are armed with physiologically active compounds to suppress the host immunity including host inflammatory reaction. However, the specific anti-inflammatory components in mosquitoes remain unknown. RESULTS: By searching for the immunomodulatory molecules from the mosquito Aedes aegypti (Diptera: Culicidae) at NCBI for anti-inflammatory function, five cecropins (for short in this study: AeaeCec1, 2, 3, 4 and 5) were selected. AeaeCec1-5 efficiently inhibited the expression of inducible nitric oxide synthase (iNOS), nitrite, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated mouse peritoneal macrophages and human peripheral blood mononuclear cells (PBMCs) with low toxicity to mammalian cells...
August 14, 2018: Parasites & Vectors
Jie Liu, Yiming Hao, Ziyuan Wang, Fang Ni, Yu Wang, Lingxiao Gong, Baoguo Sun, Jing Wang
The characteristic constituent and anti-inflammatory activity of 5-n-alkylresorcinols (ARs) from 21 wheat bran samples in China were investigated in this study. The amount of ARs ranged from 697 μg/g to 1732 μg/g in the tested samples, which were composed of five different homologues. Among these homologues, C19:0 and C21:0 were the most abundant, followed by C17:0, C23:0 and C25:0. Moreover, the mRNA expression of IL-1β, IL-6 and TNF-α in LPS-activated RAW264.7 macrophage cells were significantly inhibited by ARs supplementation...
August 14, 2018: Journal of Agricultural and Food Chemistry
Xing-He Wang, Wei Li, Xing-Hui Wang, Mei-Yu Han, Ishfaq Muhammad, Xiu-Ying Zhang, Xiao-Qi Sun, Xiao-Xu Cui
Aflatoxin B1 (AFB1) is very harmful for broiler production and public health. The water-soluble castoff in gluten production, i.e., the water-soluble substances of wheat (WSW) that contains 14% pentosan has positive effect on animal nutrient absorption, immunity, and antioxidation. Our study aims to investigate the preventive effects of WSW against AFB1-induced broiler liver injury. One day-old Arbor Acres broilers were randomly separated to 4 groups and were, respectively, fed with control diet, diet with 5 mg/kg AFB1 standard, diet with 5 mg/kg AFB1 standard and 214 ml/kg WSW, and diet with 214 ml/kg WSW continuously for 28 d...
August 13, 2018: Poultry Science
Jessalyn M Hadfield, Elizabeth C Bowdridge, Ida Holásková, Ted H Elsasser, Robert A Dailey
Innate immune response to a lipopolysaccharide (LPS) challenge varies among sheep breeds. How different breeds respond to bacterial infections impacts management practices of sheep producers. Hence, clinical response, acute-phase response, and gene expression of pro- and anti-inflammatory markers in peripheral white blood cells (WBCs) were examined after an LPS challenge in Dorset and Suffolk ewes. Ewes received either PBS or 2.5 µg/kg LPS (i.v.) 4 to 5 d after onset of synchronized estrus. Blood was collected via jugular venipuncture intermittently for 24 h to determine WBC counts...
August 9, 2018: Journal of Animal Science
Etedal Abbas Huwait
BACKGROUND: L-carnitine and Vitamin E have antioxidant properties. This study aimed to assess the effectiveness of L-carnitine, Vitamin E and the combination of them in protection against isoproterenol (ISO)-induced biochemical and histopathological changes in rat heart. MATERIAL AND METHODS: Fifty male Wistar rats assigned to 5 groups; control, ISO-treated group (100 mg/kg), ISO+vitamin E-treated group (100 IU/kg), ISO+L-carnitine (100 mg/kg) and ISO+vitamin E+L-carnitine treated group...
August 14, 2018: Folia Morphologica (Warsz)
Tao Lin, Jae Eun Lee, Jeong Won Kang, Reza K Oqani, Eun Seok Cho, Seong Bok Kim, Dong Il Jin
Poor-quality oocytes (those with 1 to 2 layers of cumulus cells) typically possess low meiotic competence and development. Prolonging the duration of in vitro maturation (IVM; 52 h) can enhance the maturation rate of poor-quality oocytes, but it does not improve subsequent embryonic development. This likely reflects the increased reactive oxygen species (ROS) production and apoptosis seen in these oocytes compared with the non-prolonged IVM (44 h) group. Melatonin is a free radical scavenger, anti-oxidant and anti-apoptotic agent that reported to enhance the quality of embryos by inhibiting ROS generation and apoptosis...
August 14, 2018: Molecular Reproduction and Development
Zhenhong Wang, Wei Zhou, Haiping Dong, Xiaoxiao Ma, Zhenzhou He
Focal ischemia/reperfusion (I/R) injury induced cerebral inflammation, aggravates brain damage. The aim of the present study was to investigate the protective mechanisms of dexmedetomidine (DEX) on I/R brain injury in rats. Sprague‑Dawley rats were divided to seven experimental groups (18 rats/group): Sham surgery; middle cerebral artery occlusion (MCAO) surgery (90 min); DEX10 [10 µg/kg intraperitoneal (i.p.) injection 30 min prior to MCAO]; DEX50 (50 µg/kg i.p. 30 min prior to MCAO); DEX100 (100 µg/kg i...
August 3, 2018: Molecular Medicine Reports
Christian Lattermann, Caitlin E-W Conley, Darren L Johnson, Emily K Reinke, Laura J Huston, Janet L Huebner, Ching-Heng Chou, Virginia B Kraus, Kurt P Spindler, Cale A Jacobs
Background: The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and the progression of osteoarthritis; however, it remains unclear if preoperative biomarkers differ for patients with inferior postoperative outcomes. Hypothesis/Purpose: The purpose of this pilot study was to compare biomarkers collected on the day of ACL reconstruction between patients with "good" or "poor" 2-year postoperative outcomes...
2018: BioMed Research International
Jowanka Amorim, Marcos de Carvalho Borges, Alexandre Todorovic Fabro, Silvia Helena Taleb Contini, Mayara Valdevite, Ana Maria Soares Pereira, Fabio Carmona
ETHNOPHARMACOLOGICAL RELEVANCE: Erythrina mulungu Benth. ("mulungu", Fabaceae) is a Brazilian native species with ethnopharmacological use for respiratory diseases. However, the effects of E. mulungu on the respiratory were never studied. AIMS OF THE STUDY: To evaluate the effects of an ethanolic extract from flowers of E. mulungu in ovalbumin (OVA)-induced asthma in mice, and to study the mechanisms involved. MATERIALS AND METHODS: OVA-sensitized mice were intraperitoneally (i...
August 10, 2018: Journal of Ethnopharmacology
Isak W Tengesdal, David Kitzenberg, Suzhao Li, Melanie S Nyuydzefe, Wei Chen, Jonathan M Weiss, Jingya Zhang, Samuel D Waksal, Alexandra Zanin-Zhorov, Charles A Dinarello
Reducing the activities of the pro-inflammatory cytokine IL-17 is an effective treatment strategy for several chronic autoimmune disorders. Rho-associated coiled-coil containing kinase 2 (ROCK2) is a member of the serine-threonine protein kinase family that regulates IL-17 secretion in T cells via signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. We reported here that the selective ROCK2 inhibitor KD025 significantly reduced in vitro production of IL-17 in unfractionated human peripheral blood mononuclear cells (PBMCs) stimulated with the dectin-1 agonist Candida albicans (C...
August 11, 2018: European Journal of Immunology
Edward D Coverstone, Richard G Bach, LiShiun Chen, Laura J Bierut, Allie Y Li, Petra A Lenzini, Heidi C O'Neill, John A Spertus, Carmen C Sucharov, Jerry A Stitzel, Joel D Schilling, Sharon Cresci
The CHRNA5 gene encodes a neurotransmitter receptor subunit involved in multiple processes, including cholinergic autonomic nerve activity and inflammation. Common variants in CHRNA5 have been linked with atherosclerotic cardiovascular disease. Association of variation in CHRNA5 and specific haplotypes with cardiovascular outcomes has not been described. The aim of this study was to examine the association of CHRNA5 haplotypes with gene expression and mortality among patients with acute myocardial infarction (AMI) and explore potential mechanisms of this association...
August 10, 2018: Basic Research in Cardiology
Qun Wang, Shuang Gao, Guo-Zhen Wu, Niao Yang, Xian-Peng Zu, Wen-Cai Li, Ning Xie, Rong-Rong Zhang, Chen-Wei Li, Zhen-Lin Hu, Wei-Dong Zhang
BACKGROUND: Inula helenium L. is an herb whose anti-inflammatory properties are attributed to its active components, the sesquiterpene lactones (SLs). Our previous study demonstrated that the total sesquiterpene lactones isolated from Inula helenium L. (TSL-IHL), consisting mainly of alantolactone (AL) and isoalantolactone (IAL), may have potential in the prevention and treatment of rheumatoid arthritis (RA). However, the effect of TSL-IHL on atopic dermatitis (AD) has not been studied yet...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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