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Anti IL-5

Yun-Ho Hwang, Su-Jin Kim, Hangun Kim, Sung-Tae Yee
Asthma is an inflammatory disease caused by an imbalance of Th1 and Th2 cells. In general, asthma is characterized by a stronger Th2 response. Most conventional asthma treatment focuses on improving airway flow or suppression of airway inflammation. To reduce the side effects of currently used asthma medicines, we have conducted studies on natural products that have no side effects. 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), the main compound of Polygonum multiflorum (PM), has various biological activities, including anti-inflammation and anti-oxidation activities...
December 12, 2018: International Journal of Molecular Sciences
Wenyu Jin, Wei Huang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao, Zhehu Jin
Atopic dermatitis (AD) is a chronic recurrent skin disease dominated by T-helper 2 inflammation. Momelotinib (MMB) is a novel JAK1/JAK2 inhibitor suppressing the signal transduction of multiple pro-inflammatory cytokines. Recent studies indicated that JAK inhibitor could play a therapeutic role in AD disease. In this study, we evaluated the efficacy of MMB as a novel JAK1/JAK2 inhibitor in DNCB-induced AD mice and TSLP-activated dendritic cells. Our data showed that topical application of MMB reduced the skin severity scores and total serum IgE levels, and alleviated the histological indexes including epidermal thickness measurement and mast cell number...
December 10, 2018: International Journal of Molecular Sciences
Igor Vladimirovich Obraztsov, Katerina Evgenievna Shirokikh, Olga Isaakovna Obraztsova, Marina Vladimirovna Shapina, Ming-Hsi Wang, Igor Lvovich Khalif
Background and Aims: Ulcerative colitis (UC) is a form of inflammatory bowel disease, and antibodies against tumor necrosis factor (anti-TNF) are used for treatment. Many patients are refractory or lose response to anti-TNF, and predicting response would be an extremely valuable clinical tool. Unlike most biomarkers, cytokines directly mediate inflammation, and their measurement may predict the likelihood of response or no response. Methods: Serum samples were obtained from 49 UC patients before infliximab infusions, and levels of 17 cytokines were measured using a multiplex assay...
December 13, 2018: Inflammatory Bowel Diseases
Fanny Legrand, Yun Cao, Joshua Wechsler, Xiang Zhu, Nives Zimmermann, Shakuntala Rampertaap, Joseph Monsale, Kimberly Romito, Bradford A Youngblood, Emily C Brock, Michelle Makiya, Nenad Tomasevic, Christopher Bebbington, Irina Maric, Dean D Metcalfe, Bruce S Bochner, Amy D Klion
BACKGROUND: Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is selectively expressed on eosinophils, mast cells and basophils, and, when engaged on eosinophils, can cause cell death. OBJECTIVE: To characterize surface and soluble Siglec-8 levels in normal (ND) and eosinophilic (EO) subjects and assess the efficacy of anti-Siglec-8 antibodies in inducing eosinophil cell death in vitro. METHODS: Eosinophil expression of Siglec-8 was assessed using flow cytometry and quantitative PCR...
December 10, 2018: Journal of Allergy and Clinical Immunology
Shuang Liang, Zheng-Tao Lv, Jia-Ming Zhang, Yu-Ting Wang, Yong-Hui Dong, Zheng-Gang Wang, Kun Chen, Peng Cheng, Qing Yang, Feng-Jing Guo, Wei-Wei Lu, Wen-Tao Zhu, An-Min Chen
Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. RIPK1 regulates inflammation and cell death by interacting with receptor-interacting serine/threonine protein kinases 3(RIPK3). We hypothesized that Nec-1 may have anti-inflammatory efficacy in patients with osteoarthritis (OA), as the pathophysiology of OA involves the activation of inflammation-related signaling pathways and apoptosis. In this study, we explored the effects of Nec-1 on interleukin (IL)-1β-induced inflammation in mouse chondrocytes and the destabilised medial meniscus (DMM) mouse model...
2018: Frontiers in Pharmacology
Antonio V Aubry, Hameda Khandaker, Rebecca Ravenelle, Itamar S Grunfeld, Valentina Bonnefil, Kenny L Chan, Flurin Cathomas, Jia Liu, Glenn E Schafe, Nesha S Burghardt
Chronic exposure to stress is a well-known risk factor for the development of mood and anxiety disorders. Promoting resilience to stress may prevent the development of these disorders, but resilience-enhancing compounds are not yet clinically available. One compound that has shown promise in the clinical setting is curcumin, a polyphenol compound found in the rhizome of the turmeric plant (Curcuma longa) with known anti-inflammatory and antidepressant properties. Here, we tested the efficacy of 1.5% dietary curcumin at promoting resilience to chronic social defeat stress (CSDS) in 129/SvEv mice, a strain that we show is highly susceptible to this type of stress...
December 12, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Ayman Samir Farid, Eman Mohamed Fath, Shogo Mido, Nariaki Nonaka, Yoichiro Horii
Infections with gastrointestinal nematodes provoke immune and inflammatory responses mediated by cytokines released from T-helper type-2 (Th2) cells. Infections with Trichinella species have been reported to differ by the host species. Previously, in rats, we observed acute liver inflammation in response to infection with Trichinella spiralis, and the rat hosts showed a series of biochemical changes characterized by a decrease in serum paraoxonase (PON)1 activity associated with the down-regulation of hepatic PON1 synthesis...
December 12, 2018: Journal of Veterinary Medical Science
Agnieszka Segiet, Paweł Smykiewicz, Piotr Kwiatkowski, Tymoteusz Żera
INTRODUCTION: A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays a critical anti-inflammatory role by binding to its receptor (IL-10Ra). The orchestrated inflammatory response is largely dependent on an intricate balance between proinflammatory and anti-inflammatory cytokines and expression of their receptors...
January 2019: Cytokine
Trinh T B Tram, Hoang N Nhung, Srinivasan Vijay, Hoang T Hai, Do D A Thu, Vu T N Ha, Tran D Dinh, Philip M Ashton, Nguyen T Hanh, Nguyen H Phu, Guy E Thwaites, Nguyen T T Thuong
It is uncertain whether differences in Mycobacterium tuberculosis ( Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of Mtb isolates collected from 153 Vietnamese adults with pulmonary tuberculosis. The virulence phenotypes were then investigated for their relationship with sputum bacterial load, bacterial lineages, bacterial growth, and cytokine responses in macrophages. Over 6 days of infection, 34 isolates (22...
2018: Frontiers in Cellular and Infection Microbiology
Moureq R Alotaibi, Amal J Fatani, Ahmed T Almnaizel, Mohammed M Ahmed, Hatem M Abuohashish, Salim S Al-Rejaie
OBJECTIVE: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. MATERIALS AND METHODS: Streptozotocin (STZ)-induced diabetic animals were orally treated with GLI and/or LT 5 and 25 mg/kg respectively for 4 weeks...
December 10, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Reza Hashemi, Mohammad Morshedi, Mohammad Asghari Jafarabadi, Davar Altafi, Seyed Saeed Hosseini-Asl, Seyed Rafie-Arefhosseini
Objective: To assess the effects of dietary vitamin D3 on proinflammatory (interleukin-17A [IL-17A] and IL-6) and anti-inflammatory (IL-10) cytokines. Methods: Our study was conducted on 75 participants who were divided into 3 groups: multiple sclerosis participants (MSPs, n = 25), first-degree relative participants (FDRPs, n = 25), and healthy participants (HPs, n = 25). All groups received 50,000 IU vitamin D3 /wk for 8 weeks. Serum 25-(OH) vitamin D3 levels and messenger RNA (mRNA) expression levels of ILs were determined using electrochemiluminescence assay and real-time PCR, respectively...
December 2018: Neurology. Genetics
Lidan Luo, Seung-Woo Kim, Hye-Kyung Lee, Il-Doo Kim, Hahnbie Lee, Ja-Kyeong Lee
Gastrodin (GAS) is a predominant bioactive constituent of the Chinese herbal medicine Tianma ( Gastrodia elata Blume). Many authors have reported GAS has the beneficial effect on diverse diseases of the CNS, including epilepsy, Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Here, we report GAS exhibited a robust neuroprotective effect in an Sprague-Dawley rat model of stroke (transient middle cerebral artery occlusion, tMCAO), and show that the underlying molecular mechanism involves its protective effect against Zn2+ -toxicity and its anti-oxidative effects in astrocytes...
2018: Animal Cells and Systems
Daniel P Henriksen, Uffe Bodtger, Kirsten Sidenius, Niels Maltbaek, Lars Pedersen, Hanne Madsen, Ehm A Andersson, Ole Norgaard, Louise Klokker Madsen, Bo L Chawes
Background : New, complex, and expensive therapies targeting Interleukin-5 (IL-5) to treat severe eosinophilic asthma are emerging. Objective : To assess efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab for treating severe eosinophilic asthma. Design : A systematic review and meta-analysis on randomized, placebo-controlled, clinical trials elucidating two critical (exacerbation rate and oral corticosteroid (OCS) use) and six important clinical outcomes on the efficacy and safety of mepolizumab and reslizumab...
2018: European Clinical Respiratory Journal
Cheryl P Ferrufino, Julie Munakata, Wenhui Wei, Clare Proudfoot, Andreas Kuznik, Susan H Boklage, Chieh-I Chen
Objective: To estimate the 5-year budget impact (BI) on a US health plan of introducing sarilumab - a human immunoglobulin G1 anti-IL-6 receptor α monoclonal antibody - as combination treatment with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or monotherapy in patients with moderate-to-severe rheumatoid arthritis (RA). Methods: BI analysis was conducted from a commercial payer perspective. Treatment-eligible populations included adult patients with moderate-to-severe RA and inadequate response (IR) to csDMARDs or tumor necrosis factor (TNF)-α inhibitors-IR...
2018: ClinicoEconomics and Outcomes Research: CEOR
Jing Wu, Fu-Tao Zhao, Kai-Jian Fan, Jun Zhang, Bing-Xing Xu, Qi-Shan Wang, Ting-Ting Tang, Ting-Yu Wang
Dihydromyricetin (DMY), the main flavonoid of Ampelopsis grossedentata, has a potent anti-inflammation activity. However, the effect of DMY on the chronic autoimmune arthritis remains undefined. In this study we investigated the therapeutic effects of DMY on collagen-induced arthritis (CIA). Wistar rats were immunized with bovine type II collagen to establish CIA and then administered intraperitoneally (i.p.) with DMY (5, 25 and 50 mg/kg) every other day for five weeks. Paw swelling, clinical scoring and histologic analysis were performed to determine the therapeutic effects of DMY on arthritis development in CIA rats...
December 10, 2018: Journal of Pharmacology and Experimental Therapeutics
Ines Lakhal-Naouar, Nancy Koles, Mangala Rao, Elaine B Morrison, John M Childs, Carl R Alving, Naomi E Aronson
Leishmaniasis is an expanding health threat worldwide complicated by the absence of an effective vaccine. We investigated transcutaneous immunization (TCI) as a needle-free immunization route which exploits the abundance of antigen presenting cells in the skin to induce both mucosal and systemic immunity. Leishmania (L.) major soluble antigens (SLA) or recombinant Leishmania homolog of receptors for activated C-kinase (rLACK) antigens were delivered transcutaneously together with cholera toxin (CT), to BALB/c mice...
December 5, 2018: Vaccine
Mary Clare McGregor, James G Krings, Parameswaran Nair, Mario Castro
Patients with severe uncontrolled asthma have disproportionally high morbidity and health care utilization as compared to their peers with well-controlled disease. While treatment options for these patients were previously limited with unacceptable side effects, the emergence of biologic therapies for the treatment of asthma has provided promising targeted therapy for these patients. Biologic therapies target specific inflammatory pathways involved in the pathogenesis of asthma, particularly in patients with an endotype driven by type 2 (T2) inflammation...
December 10, 2018: American Journal of Respiratory and Critical Care Medicine
Mônica Pezenatto Dos Santos, Mayara Luciana Sallas, Diana Zapparoli, Wilson Aparecido Orcini, Elizabeth Chen, Marilia de Arruda Cardoso Smith, Spencer L Marques Payão, Lucas Trevizani Rasmussen
The process of combating neoplasms and mononuclear cells, and during H. pylori infection, several pro-inflammatory and anti-inflammatory cytokines are synthesized. In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms. A total of 375 samples were analyzed: 87 patients (without lesion without gastric tissue); 236 patients with gastritis and 52 patients with gastric cancer analyzed the PCR-RFLP techniques...
December 7, 2018: Journal of Cellular Biochemistry
Frank M Schmidt, Christian Sander, Juliane Minkwitz, Roland Mergl, Bethan Dalton, Lesca M Holdt, Daniel Teupser, Ulrich Hegerl, Hubertus Himmerich
Background: The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related to poor antidepressant treatment outcome. Therefore, mediators of inflammation may bridge the relationship between neuroticism and depression. Methods: To disentangle these interrelationships, the associations between neuroticism (according to NEO-PIR-N), depressive symptoms (BDI-II scores) and serum levels of hsCRP, TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, GM-CSF were investigated in a group of 212 participants, consisting of 37 depressed and 175 non-depressed subjects...
2018: Frontiers in Psychiatry
Da-Wei Lian, Yi-Fei Xu, Wen-Kang Ren, Li-Jun Fu, Fang-Jun Chen, Li-Yao Tang, Hui-Ling Zhuang, Hong-Ying Cao, Ping Huang
Patchouli alcohol (PA), a natural tricyclic sesquiterpene extracted from Pogostemon cablin (Blanco) Benth. (Labiatae), has been found to exhibit anti- Helicobacter pylori and anti-inflammatory properties. In this study, we investigated the protective effect of PA against H. pylori- induced gastritis in vitro and in vivo , and determined the underlying mechanism. In the in vivo experiment, a C57BL/6 mouse model of gastritis was established using H. pylori SS1, and treatments with standard triple therapy or 5, 10, and 20 mg/kg PA were performed for 2 weeks...
2018: Frontiers in Pharmacology
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