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Antibiotics appendicitis

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https://www.readbyqxmd.com/read/29762016/rapid-2-ms-interrogation-of-electrochemical-aptamer-based-sensor-response-using-intermittent-pulse-amperometry
#1
Mirelis Santos-Cancel, Robert Alexander Lazenby, Ryan J White
In this manuscript, we employ the technique intermittent pulse amperometry (IPA) to interrogate equilibrium and kinetic target binding to the surface of electrochemical, aptamer-based (E-AB) sensors, achieving as fast as 2 ms time resolution. E-AB sensors comprise an electrode surface modified with a flexible nucleic acid aptamer tethered at the 3'-terminus with a redox-active molecule. The introduction of a target changes the conformation and flexibility of the nucleic acid which alters the charge transfer rate of the appended redox molecule...
May 15, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29744045/a-case-report-on-recurrent-appendicitis-an-often-forgotten-and-atypical-cause-of-recurrent-abdominal-pain
#2
Mesfin Demeke Mengesha, Gebreyohans Gebru Teklu
Introduction: Recurrent appendicitis is a disease process, distinct from acute appendicitis, which occurs with an approximate incidence of 10%. This clinical entity can pose diagnostic and therapeutic dilemma for clinicians resulting in delayed diagnosis and severe complications. Presentation of case: Herein, we described a case of recurrent appendicitis with a history of 18 years of right lower quadrant (RLQ) abdominal pain with very mild tenderness that we encountered in our hospital in January 2016, which has been misjudged as other abdominal conditions and got complete relief after appendectomy...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29741752/abdominal-drainage-to-prevent-intra-peritoneal-abscess-after-open-appendectomy-for-complicated-appendicitis
#3
REVIEW
Zhe Li, Longshuan Zhao, Yao Cheng, Nansheng Cheng, Yilei Deng
BACKGROUND: Appendectomy, the surgical removal of the appendix, is performed primarily for acute appendicitis. Patients who undergo appendectomy for complicated appendicitis, defined as gangrenous or perforated appendicitis, are more likely to suffer from postoperative complications. The routine use of abdominal drainage to reduce postoperative complications after appendectomy for complicated appendicitis is controversial.This is an update of the review first published in 2015. OBJECTIVES: To assess the safety and efficacy of abdominal drainage to prevent intra-peritoneal abscess after open appendectomy for complicated appendicitis...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29732138/a-rare-presentation-of-acute-appendicitis-in-right-upper-quadrant-caused-by-renal-agenesis
#4
Han N Beh, Yuni F Ongso
Diagnosing acute abdominal pain will always be a challenging task, patients frequently present with atypical symptoms. It is crucial for a clinician to have good differential diagnosis to avoid delay in diagnosis and treatment. We present 37-year-old male who presented to emergency department with 2 days of abdominal pain. The pain started centrally around his umbilicus and localized to his right upper quadrant (RUQ). Clinical examination showed he has localized peritonitism on the RUQ hence he was further investigated with CT abdomen...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29720238/two-versus-five-days-of-antibiotics-after-appendectomy-for-complex-acute-appendicitis-appic-study-protocol-for-a-randomized-controlled-trial
#5
Anne Loes van den Boom, Elisabeth M L de Wijkerslooth, Joost van Rosmalen, Frédérique H Beverdam, Evert-Jan G Boerma, Marja A Boermeester, Joanna W A M Bosmans, Thijs A Burghgraef, Esther C J Consten, Imro Dawson, Jan Willem T Dekker, Marloes Emous, Anna A W van Geloven, Peter M N Y H Go, Luc A Heijnen, Sander A Huisman, Dayanara Jean Pierre, Joske de Jonge, Jurian H Kloeze, Marc A Koopmanschap, Hester R Langeveld, Misha D P Luyer, Damian C Melles, Johan W Mouton, Augustinus P T van der Ploeg, Floris B Poelmann, Jeroen E H Ponten, Charles C van Rossem, Wilhelmina H Schreurs, Joël Shapiro, Pascal Steenvoorde, Boudewijn R Toorenvliet, Joost Verhelst, Hendt P Versteegh, Rene M H Wijnen, Bas P L Wijnhoven
BACKGROUND: Acute appendicitis is one of the most common indications for emergency surgery. In patients with a complex appendicitis, prolonged antibiotic prophylaxis is recommended after appendectomy. There is no consensus regarding the optimum duration of antibiotics. Guidelines propose 3 to 7 days of treatment, but shorter courses may be as effective in the prevention of infectious complications. At the same time, the global issue of increasing antimicrobial resistance urges for optimization of antibiotic strategies...
May 2, 2018: Trials
https://www.readbyqxmd.com/read/29697421/a-case-report-and-literature-review-of-scrub-typhus-with-acute-abdomen-and-septic-shock-in-a-child-the-role-of-leukocytoclastic-vasculitis-and-granulysin
#6
Po-Hsiung Chang, Yu-Pin Cheng, Po-Sheng Chang, Chiao-Wei Lo, Lung-Huang Lin, Chin-Fang Lu, Wen-Hung Chung
Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. It has various systemic manifestations, including GI symptoms. In some, the illness progresses to multiorgan dysfunction syndrome and death...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29680415/home-antibiotics-at-discharge-for-pediatric-complicated-appendicitis-friend-or-foe
#7
Kathryn Tinsley Anderson, Marisa A Bartz-Kurycki, Akemi L Kawaguchi, Mary T Austin, Galit Holzmann-Pazgal, Lillian S Kao, Kevin P Lally, Kuojen Tsao
BACKGROUND: The role of home discharge antibiotics in children after perforated appendicitis is unclear. This study evaluates the outcomes of complicated appendicitis patients being discharged with or without home antibiotics after initial surgery and in-patient treatment. STUDY DESIGN: The 2015 and 2016 National Surgical Quality Improvement-Pediatric (NSQIP-P) database was queried for patients <18 years of age with complicated appendicitis. Home antibiotics (HA) were prescribed or not (No Home Antibiotics- NHA)...
April 19, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29678565/simplification-of-first-line-antibacterial-regimen-for-complicated-appendicitis-in-children-was-associated-with-better-adherence-to-guidelines-and-reduced-use-of-antibiotics
#8
Marion Taleb, Nicolas Nardi, Alexis Arnaud, Nathalie Costet, Pierre-Yves Donnio, Charlotte Engrand, Edouard Habonimana, Eric Wodey, Pierre Tattevin
Acute appendicitis in children requires early surgery, and a short course of antibiotics active on Enterobacteriaceae and anaerobes. Although aminoglycoside-containing 3-drug regimen have been used successfully for decades, simpler regimens with similar efficacy are increasingly used. We aimed to evaluate the impact of a switch from the combination of cefotaxime, metronidazole, and gentamicin (regimen 1), to piperacillin-tazobactam (regimen 2), as first-line regimen for complicated acute appendicitis in children...
April 17, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29663311/interobserver-variability-in-the-classification-of-appendicitis-during-laparoscopy
#9
A L van den Boom, E M L de Wijkerslooth, K A L Mauff, I Dawson, C C van Rossem, B R Toorenvliet, B P L Wijnhoven
BACKGROUND: The intraoperative classification of appendicitis dictates the patient's postoperative management. Prolonged antibiotic prophylaxis is recommended for complex appendicitis (gangrenous, perforated, abscess), whereas preoperative prophylaxis suffices for simple appendicitis. Distinguishing these two conditions can be challenging. The aim of this study was to assess interobserver variability in the classification of appendicitis during laparoscopy. METHODS: Short video recordings taken during laparoscopy for suspected appendicitis were shown to surgeons and surgical residents...
April 16, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29628008/abdominal-drainage-after-laparoscopic-appendectomy-in-children-an-endless-controversy
#10
B Aneiros Castro, I Cano, A García, P Yuste, E Ferrero, A Gómez
BACKGROUND: Routine prophylactic abdominal drains after laparoscopic appendectomy for perforated appendicitis in children are still controversial. Throughout the history of surgery, potential benefits of the abdominal drains have been described. However, in recent studies, no benefits were observed and serious complications have been reported. METHODS: From January 2000 to December 2013, all charts of the pediatric patients who underwent laparoscopic appendectomy in our tertiary center were revised...
April 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29621001/antibiotic-use-and-antimicrobial-resistance-of-surgical-patients-with-peritonitis-at-a-tertiary-referral-hospital-in-rwanda
#11
Jennifer Rickard, Christian Ngarambe, Leonard Ndayizeye, Blair Smart, Robert Riviello, Jean Paul Majyambere, Rahel G Ghebre
BACKGROUND: There is growing recognition of the worsening problem of antibiotic resistance and the need for antibiotic stewardship in low-resource settings. The aim of this study was to describe antibiotic use and antimicrobial resistance in patients undergoing surgery for peritonitis at a Rwandan referral hospital. PATIENTS AND METHODS: All surgical patients with peritonitis at a Rwandan referral hospital were enrolled. Prospective data were collected on epidemiology, clinical features, interventions, and outcomes...
April 5, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29600927/-a-child-with-abdominal-pain-and-fever-consider-acute-lobar-nephritis-diagnostic-considerations-when-the-appendix-is-invisible-on-ultrasound
#12
A M Bakker, G H E J Vijgen, N G Hartwig, G A Tramper-Stranders
Acute lobar nephritis (ALN) is a focal interstitial bacterial infection of the renal parenchyma. ALN is described as a midpoint between an acute pyelonephritis and renal abscess. ALN is underdiagnosed in children due to both non-specific symptoms and negative urinalysis/bacteriuria laboratory findings. The gold standard for diagnosis of ALN is CT scanning, however MRI can be considered to avoid radiation exposure. Diagnosing ALN is relevant, because it requires prolonged antibiotic treatment. Insufficient antibiotic treatment could cause renal scarring and subsequent hypertension or renal failure...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29598912/novel-purine-benzimidazoles-as-antimicrobial-agents-by-regulating-ros-generation-and-targeting-clinically-resistant-staphylococcus-aureus-dna-groove
#13
Ya-Nan Wang, Rammohan R Yadav Bheemanaboina, Gui-Xin Cai, Cheng-He Zhou
A novel series of purine benzimidazole hybrids were designed and synthesized for the first time with the aim to circumvent the increasing antibiotic resistance. Hexyl appended hybrid 3c gave potent activities against most of the tested bacteria and fungi especially against multidrug-resistant strains Staphylococcus aureus (MIC = 4 µg/mL). Structure-activity relationships revealed that the benzimidazole fragment at the 9-position of purine played an important role in exerting potentially antibacterial activity...
March 19, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29595695/comamonas-kerstersii-bacteremia-in-a-patient-with-acute-perforated-appendicitis-a-rare-case-report
#14
Yun-Heng Zhou, Hong-Xia Ma, Zhao-Yang Dong, Mei-Hua Shen
RATIONALE: Comamonas species are rarely associated with human infections. Recent reports found that Comamonas kerstersii was associated with severe diseases such as abdominal infection and bacteremia. However, C. kerstersii maybe be confused with Comamonas testosteroni using the automatic bacterial identification systems currently available. PATIENT CONCERNS: A 31-year-old man who had onset of left upper abdominal pain developed clinical manifestations of right lower abdominal pain and classic migration of pain at the temperature of 39°C...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29541448/multidrug-resistant-gram-negative-bacterial-infections-in-a-teaching-hospital-in-ghana
#15
Nicholas Agyepong, Usha Govinden, Alex Owusu-Ofori, Sabiha Yusuf Essack
Background: Multidrug-resistant Gram-negative bacteria have emerged as major clinical and therapeutic dilemma in hospitals in Ghana.To describe the prevalence and profile of infections attributable to multidrug-resistant Gram-negative bacteria among patients at the Komfo Anokye Teaching Hospital in the Ashanti region of Ghana. Methods: Bacterial cultures were randomly selected from the microbiology laboratory from February to August, 2015. Bacterial identification and minimum inhibitory concentrations were conducted using standard microbiological techniques and the Vitek-2 automated system...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29533601/structural-insights-into-the-free-standing-condensation-enzyme-sgcc5-catalyzing-ester-bond-formation-in-the-biosynthesis-of-the-enediyne-antitumor-antibiotic-c-1027
#16
Chin-Yuan Chang, Jeremy R Lohman, Tingting Huang, Karolina Michalska, Lance Bigelow, Jeffrey D Rudolf, Robert Jedrzejczak, Xiaohui Yan, Ming Ma, Gyorgy Babnigg, Andrzej Joachimiak, George N Phillips, Ben Shen
C-1027 is a chromoprotein enediyne antitumor antibiotic, consisting of the CagA apo-protein and the C-1027 chromophore. The C-1027 chromophore features a nine-membered enediyne core appended with three peripheral moieties, including an (S)-3-chloro-5-hydroxy--tyrosine. In a convergent biosynthesis of the C-1027 chromophore, the (S)-3-chloro-5-hydroxy--tyrosine moiety is appended to the enediyne core by the free-standing condensation enzyme SgcC5. Unlike canonical condensation domains from the modular nonribosomal peptide synthetases that catalyze amide bond formation, SgcC5 catalyzes ester bond formation, as demonstrated in vitro, between SgcC2-tethered (S)-3-chloro-5-hydroxy-β-tyrosine and (R)-1-phenyl-1,2-ethanediol, a mimic of the enediyne core as an acceptor substrate...
March 13, 2018: Biochemistry
https://www.readbyqxmd.com/read/29499722/contract-study-conservative-treatment-of-appendicitis-in-children-feasibility-study-protocol-for-a-randomised-controlled-trial
#17
Natalie Hutchings, Wendy Wood, Isabel Reading, Erin Walker, Jane M Blazeby, William Van't Hoff, Bridget Young, Esther M Crawley, Simon Eaton, Maria Chorozoglou, Frances C Sherratt, Lucy Beasant, Harriet Corbett, Michael P Stanton, Simon Grist, Elizabeth Dixon, Nigel J Hall
BACKGROUND: Currently, the routine treatment for acute appendicitis in the United Kingdom is an appendicectomy. However, there is increasing scientific interest and research into non-operative treatment of appendicitis in adults and children. While a number of studies have investigated non-operative treatment of appendicitis in adults, this research cannot be applied to the paediatric population. Ultimately, we aim to perform a UK-based multicentre randomised controlled trial (RCT) to test the clinical and cost effectiveness of non-operative treatment of acute uncomplicated appendicitis in children, as compared with appendicectomy...
March 2, 2018: Trials
https://www.readbyqxmd.com/read/29497573/nonoperative-treatment-of-appendicitis-during-pregnancy-in-a-remote-area
#18
Anne-Kathrine Carstens, Lise Fensby, Luit Penninga
Appendicitis is the most common nonobstetric surgical disease during pregnancy. Appendicitis during pregnancy is associated with an increased risk of morbidity and perforation compared with the general population. Furthermore, it may cause preterm birth and fetal loss, and quick surgical intervention is the established treatment option in pregnant women with appendicitis. In Greenland, geographical distances are very large, and weather conditions can be extreme, and surgical care is not always immediately available...
January 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29488087/bacterial-culture-and-antibiotic-susceptibility-in-patients-with-acute-appendicitis
#19
Dae Woon Song, Byung Kwan Park, Suk Won Suh, Seung Eun Lee, Jong Won Kim, Joong-Min Park, Hye Ryoun Kim, Mi-Kyung Lee, Yoo Shin Choi, Beom Gyu Kim, Yong Gum Park
PURPOSE: Essential treatment of acute appendicitis is surgical resection with the use of appropriate antibiotics. In order to effectively treat acute appendicitis, it is important to identify the microorganism of acute appendicitis and evaluate the effective antibiotics. METHODS: A total of 694 patients who underwent appendectomy for acute appendicitis and had positive microbial result between 2006 and 2015 were recruited. For microbial assessment, luminal contents of the appendix were swabbed after appendectomy...
April 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470473/liver-abscess-contemporary-presentation-and-management-in-a-western-population
#20
Kareem Osman, Sanket Srinivasa, Jonathan Koea
AIM: Historically, liver abscesses (LA) affected elderly, immunocompromised patients and were characterised by high morbidity and mortality, however there are no data pertaining to a New Zealand population with little information surrounding recent management trends. METHODS: A retrospective review of demographic characteristics, clinical management and microbiological data on patients presenting with liver abscess between 2005-2014 was conducted. RESULTS: Fifty-seven patients [37 males, median age 64 (range 15-87)] presented with LA and most patients were not comorbid...
February 23, 2018: New Zealand Medical Journal
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