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Cannabidiol

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https://www.readbyqxmd.com/read/28434588/the-endocannabinoid-system-as-a-target-for-novel-anxiolytic-drugs
#1
REVIEW
Sachin Patel, Mathew N Hill, Joseph F Cheer, Carsten T Wotjak, Andrew Holmes
The endocannabinoid (eCB) system has attracted attention for its role in various behavioral and brain functions, and as a therapeutic target in neuropsychiatric disease states, including anxiety disorders and other conditions resulting from dysfunctional responses to stress. In this mini-review, we highlight components of the eCB system that offer potential 'druggable' targets for new anxiolytic medications, emphasizing some of the less well-discussed options. We discuss how selectively amplifying eCBs recruitment by interfering with eCB-degradation, via fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), has been linked to reductions in anxiety-like behaviors in rodents and variation in human anxiety symptoms...
May 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28424834/effect-of-prior-foot-shock-stress-and-%C3%AE-9-tetrahydrocannabinol-cannabidiolic-acid-and-cannabidiol-on-anxiety-like-responding-in-the-light-dark-emergence-test-in-rats
#2
Erin M Rock, Cheryl L Limebeer, Gavin N Petrie, Lauren A Williams, Raphael Mechoulam, Linda A Parker
RATIONALE: Cannabis is commonly used by humans to relieve stress. OBJECTIVES AND METHODS: Here, we evaluate the potential of intraperitoneally (i.p.) administered Δ(9)-tetrahydrocannabiol (THC) and cannabidiolic acid (CBDA, the precursor of cannabidiol [CBD]) to produce dose-dependent effects on anxiety-like responding in the light-dark (LD) emergence test of anxiety-like responding in rats, when administered acutely or chronically (21 days). As well, we evaluate the potential of THC, CBDA, and CBD to reduce anxiogenic responding produced by foot shock (FS) stress 24 h prior to the LD test...
April 20, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28419252/sensitive-determination-of-cannabinoids-in-whole-blood-by-lc-ms-ms-after-rapid-removal-of-phospholipids-by-filtration
#3
Lambert K Sørensen, Jørgen B Hasselstrøm
Direct analysis of Δ9-tetrahydrocannabinol (THC) and other cannabinoids in crude acetonitrile extracts of whole blood by liquid chromatography-tandem mass spectrometry using pneumatically assisted electrospray ionization (LC-ESI-MS-MS) was subjected to pronounced ion suppression from co-eluting phospholipids (PLs). The interferences were mainly caused by the lysophosphatidylcholine and lysophosphatidylethanolamine classes of PLs. The PLs were easily removed from crude extracts by filtration through a sorbent with Lewis acid properties, which typically increased the THC and cannabinol (CBN) signal intensities by a factor of 5...
April 17, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28412920/neuropsychiatric-and-general-interactions-of-natural-and-synthetic-cannabinoids-with-drugs-of-abuse-and-medicines
#4
Ana Lucia Arellano, Esther Papaseit, Anna Romaguera, Marta Torrens, Magi Farré
Cannabis is the most widely used illicit drug. The two most important natural cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The THC content of cannabis has been increasing during the last years and recently appeared in the market a series of synthetic cannabinoids with potent agonist activity. Recreational users frequently combine cannabis with other drugs of abuse as alcohol, amphetamines and derivatives, nicotine and cocaine. In addition these subjects can be taking medicines for acute and chronic medical conditions...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28412918/neurological-aspects-of-medical-use-of-cannabidiol
#5
Carmen Mannucci, Michele Navarra, Fabrizio Calapai, Elvira Ventura Spagnolo, Francesco Paolo Busardò, Roberto Da Cas, Francesca Menniti Ippolito, Gioacchino Calapai
BACKGROUND: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activi-ties and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28397674/-self-medication-with-cannabidiol-oil-in-a-patient-with-primary-lateral-sclerosis
#6
Merete Karlsborg, Anette Kvindebjerg Christophersen, Caroline Pontoppidan, Jens Peter Kampmann
Many patients with neurological disorders have symptoms which are difficult to treat with conventional medication. In this case report we present a 40-year-old male patient with primary lateral sclerosis who used cannabidiol oil as therapy. We discuss the evidence of the effects of cannabidiol in the treatment of patients with neurological disease, and we raise the question: "Should patients who use illegal cannabis products as self-medication be diagnosed as drug abusers?"
February 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28392943/report-from-a-survey-of-parents-regarding-the-use-of-cannabidiol-medicinal-cannabis-in-mexican-children-with-refractory-epilepsy
#7
Carlos G Aguirre-Velázquez
Structured online surveys were used to explore the experiences of the parents of children with refractory epilepsy using medicinal cannabis in Mexico during September 2016. The surveys, which were completed in full, were reviewed, and 53 cases of children aged between 9 months and 18 years were identified. Of these, 43 cases (82%) were from Mexico and 10 (18%) were from Latin American countries. Of the 43 Mexican cases, the diagnoses were as follows: 20 cases (47%) had Lennox-Gastaut syndrome (LGS); 13 cases (30%) had unspecified refractory epilepsy (URE); 8 cases (19%) had West syndrome (WS); 1 case (2%) had Doose syndrome (DS); and 1 case (2%) had Ohtahara syndrome (OS)...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28392768/cannabidiol-reduces-leukemic-cell-size-but-is-it-important
#8
Nikoletta Kalenderoglou, Tara Macpherson, Karen L Wright
The anti-cancer effect of the plant-derived cannabinoid, cannabidiol, has been widely demonstrated both in vivo and in vitro. However, this body of preclinical work has not been translated into clinical use. Key issues around this failure can be related to narrow dose effects, the cell model used and incomplete efficacy. A model of acute lymphoblastic disease, the Jurkat T cell line, has been used extensively to study the cannabinoid system in the immune system and cannabinoid-induced apoptosis. Using these cells, this study sought to investigate the outcome of those remaining viable cells post-treatment with cannabidiol, both in terms of cell size and tracking any subsequent recovery...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28392266/cannabinoids-as-hippocampal-network-administrators
#9
REVIEW
Carl R Lupica, Yuhan Hu, Orrin Devinsky, Alexander F Hoffman
Extensive pioneering studies performed in the hippocampus have greatly contributed to our knowledge of an endogenous cannabinoid system comprised of the molecular machinery necessary to process these endocannabinoid lipid messengers and their associated cannabinoid receptors. Moreover, a foundation of knowledge regarding the function of hippocampal circuits, and its role in supporting synaptic plasticity has facilitated our understanding of the roles cannabinoids play in the diverse behaviors in which the hippocampus participates in both normal and pathological states...
April 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28388598/cannabidiol-reduces-lung-injury-induced-by-hypoxic-ischemic-brain-damage-in-newborn-piglets
#10
Luis Arruza, Maria Ruth Pazos, Nagat Mohammed, Natalia Escribano, Hector Lafuente, Martín Santos, Francisco J Alvarez-Díaz, William Hind, Jose Martínez-Orgado
BACKGROUND: Brain hypoxic-ischemic (HI) damage induces distant inflammatory lung damage in newborn pigs. We aimed to investigate the effects of cannabidiol (CBD) on lung damage in this scenario. METHODS: Newborn piglets received i.v. vehicle, CBD or CBD+WAY100635 (5-HT1A receptor antagonist) after HI brain damage (carotid flow interruption and FiO2 0.10 for 30 min). Total lung compliance (TLC), oxygenation index (OI) and extravascular lung water content (EVLW) were monitored for six hours...
April 7, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28377033/cannabidiol-claims-and-misconceptions-trends-in-pharmacological-sciences-38-198-201-2017
#11
Ethan B Russo
No abstract text is available yet for this article.
May 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28375061/novel-biotherapies-are-needed-in-youth-mental-health
#12
G Paul Amminger, Maximus Berger, Simon M Rice, Christopher G Davey, Miriam R Schäfer, Patrick D McGorry
Adverse effects and lack of efficacy in a significant number of patients limit pharmaceutical interventions in youth psychiatry. This is exemplified by the fact that no medication is currently approved for the treatment of non-OCD anxiety disorders or major depressive disorder in young people younger than 18 years of age in Australia. Here, emerging biological therapies for youth with mental health problems are discussed. There is an urgent need for more research into biological interventions with acceptable risk-benefit balances...
April 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28372838/development-and-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-the-determination-of-cannabinoids-and-phase-i-and-ii-metabolites-in-meconium
#13
Pablo Prego-Meleiro, Elena Lendoiro, Marta Concheiro, Angelines Cruz, Manuel López-Rivadulla, Ana de Castro
A liquid chromatography-tandem mass spectrometry (LC-MSMS) method was developed and fully validated for the determination of Δ(9)-tetrahydrocannabinol (THC), 11-hydroxyTHC (OHTHC), 11-nor-9-carboxyTHC (THCCOOH), 8-β-11-dihydroxyTHC (diOHTHC), cannabinol, cannabidiol, and THC and THCCOOH glucuronides in 0.25±0.02g meconium. Samples were homogenized in methanol and subjected to cation exchange solid-phase extraction. Chromatographic separation was performed on a Kinetex C18 column (50 mm×2.1mm, 2.6μm) at 35°C, with a gradient of 0...
March 25, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28370214/cover-image-volume-118-number-6-june-2017
#14
Thangavelu Soundara Rajan, Sabrina Giacoppo, Domenico Scionti, Francesca Diomede, Gianpaolo Grassi, Federica Pollastro, Adriano Piattelli, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani
Cover: The cover image, by Emanuela Mazzon et al., is based on the Article Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells, DOI: 10.1002/jcb.25815.
June 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28367124/protective-effects-of-cannabidiol-against-seizures-and-neuronal-death-in-a-rat-model-of-mesial-temporal-lobe-epilepsy
#15
Raquel A Do Val-da Silva, Jose E Peixoto-Santos, Ludmyla Kandratavicius, Jana B De Ross, Ingrid Esteves, Bruno S De Martinis, Marcela N R Alves, Renata C Scandiuzzi, Jaime E C Hallak, Antonio W Zuardi, Jose A Crippa, Joao P Leite
The present study reports the behavioral, electrophysiological, and neuropathological effects of cannabidiol (CBD), a major non-psychotropic constituent of Cannabis sativa, in the intrahippocampal pilocarpine-induced status epilepticus (SE) rat model. CBD was administered before pilocarpine-induced SE (group SE+CBDp) or before and after SE (group SE+CBDt), and compared to rats submitted only to SE (SE group), CBD, or vehicle (VH group). Groups were evaluated during SE (behavioral and electrophysiological analysis), as well as at days one and three post-SE (exploratory activity, electrophysiological analysis, neuron density, and neuron degeneration)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28349316/cannabis-cannabinoids-and-sleep-a-review-of-the-literature
#16
REVIEW
Kimberly A Babson, James Sottile, Danielle Morabito
PURPOSE OF REVIEW: The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and specific sleep disorders from 2014 to the time of publication. RECENT FINDINGS: Preliminary research into cannabis and insomnia suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia. Delta-9 tetrahydrocannabinol (THC) may decrease sleep latency but could impair sleep quality long-term...
April 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28349233/low-dose-cannabidiol-is-safe-but-not-effective-in-the-treatment-for-crohn-s-disease-a-randomized-controlled-trial
#17
Timna Naftali, Refael Mechulam, Amir Marii, Gila Gabay, Asaf Stein, Miriam Bronshtain, Ido Laish, Fabiana Benjaminov, Fred M Konikoff
BACKGROUND: Cannabidiol (CBD) is an anti-inflammatory cannabinoid shown to be beneficial in a mouse model of IBD. Lacking any central effect, cannabidiol is an attractive option for treating inflammatory diseases. AIM: To assess the effects of cannabidiol on Crohn's disease in a randomized placebo-controlled trial. PATIENTS AND METHODS: Twenty patients aged 18-75 years with a Crohn's disease activity index (CDAI) >200 were randomized to receive oral (10 mg) CBD or placebo twice daily...
March 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28344554/cannabis-in-chinese-medicine-are-some-traditional-indications-referenced-in-ancient-literature-related-to-cannabinoids
#18
REVIEW
E Joseph Brand, Zhongzhen Zhao
Cannabis sativa L. (Cannabaceae) has a long history of utilization as a fiber and seed crop in China, and its achenes ("seeds") as well as other plant parts have been recorded in Chinese medical texts for nearly 2000 years. While the primary applications of cannabis in Chinese medicine center around the use of the achenes, ancient indications for the female inflorescence, and other plant parts include conditions such as pain and mental illness that are the subject of current research into cannabinoids such as cannabidiol (CBD) and Δ(9)-tetrahydrocannabinol (THC)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28344069/selective-post-training-time-window-for-memory-consolidation-interference-of-cannabidiol-into-the-prefrontal-cortex-reduced-dopaminergic-modulation-and-immediate-gene-expression-in-limbic-circuits
#19
Matheus Teixeira Rossignoli, Cleiton Lopes-Aguiar, Rafael Naime Ruggiero, Raquel Araujo Do Val da Silva, Lezio Soares Bueno-Junior, Ludmyla Kandratavicius, José Eduardo Peixoto-Santos, José Alexandre Crippa, Jaime Eduardo Cecilio Hallak, Antonio Waldo Zuardi, Raphael Escorsim Szawka, Janete Anselmo-Franci, João Pereira Leite, Rodrigo Neves Romcy-Pereira
The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories. Evidence indicates that PFC engagement in aversive memory formation does not progress linearly as previously thought. Instead, it seems to be recruited at specific time windows after memory acquisition, which has implications for the treatment of post-traumatic stress disorders. Cannabidiol (CBD), the major non-psychotomimetic phytocannabinoid of the Cannabis sativa plant, is known to modulate contextual fear memory acquisition in rodents...
March 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28343385/development-of-a-rapid-lc-ms-ms-method-for-the-quantification-of-cannabidiol-cannabidivarin-%C3%AE-9-tetrahydrocannabivarin-and-cannabigerol-in-mouse-peripheral-tissues
#20
Fabiana Piscitelli, Ester Pagano, Anna Lauritano, Angelo A Izzo, Vincenzo Di Marzo
Cannabis has been known as a medicine for several thousand years across many cultures and its beneficial effects are mostly due to the presence of cannabinoids, unique natural products, whose pharmacology is going to gain increasing interest in the scientific community. The discovery of the main psychoactive constituent of Cannabis sativa L., Δ(9)-tetrahydrocannabinol (Δ(9)-THC), led to the identification of at least 100 additional phytocannabinoids, including cannabidiol (CBD), cannabidivarin (CBDV), Δ(9)-tetrahydrocannabivarin (Δ(9)-THCV), and cannabigerol (CBG)...
April 3, 2017: Analytical Chemistry
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