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gallstone OR cholelithiasis

Toshikatsu Nitta, Yoshihide Chino, Jun Kataoka, Masahito Ohta, Tomo Tominaga, Kensuke Fujii, Takashi Ishibashi
INTRODUCTION: A 50-year-old Japanese man presented with obstructive jaundice. We performed endoscopic retrograde biliary drainage before biliary decompression. CT showed a thickened gallbladder wall with low-density areas and a 35-mm gallstone; the stone was impacted in the gallbladder neck and cystic duct. The patient was therefore diagnosed with Mirizzi syndrome (type II or III) and scheduled for laparoscopic treatment. We performed subtotal cholecystectomy and intraoperative choledochoscopy because we recognized a fistula between the gallbladder and common bile duct preoperatively...
December 13, 2018: Asian Journal of Endoscopic Surgery
Frédéric Borel, Julien Branche, Grégory Baud, Romain Gérard, François Pattou, Robert Caiazzo
BACKGROUND: The incidence of biliary lithiasis is increased after bariatric surgery due to rapid weight loss [1]. Trans-oral endoscopic management in cases of common bile duct gallstone complication is not possible in patients with Roux-en-Y gastric bypass (RYGB) due to the modified anatomy. Access to the biliary tree after RYGB with a classical direct surgical approach of common bile duct and choledocoscopy can be used, but may be complicated in situations of acute cholangitis because of the fragility of common duct, or in cases of previous cholecystectomy...
December 11, 2018: Obesity Surgery
David W da Costa, Nicolien J Schepers, Stefan A Bouwense, Robbert A Hollemans, Hjalmar C van Santvoort, Thomas L Bollen, Esther C Consten, Harry van Goor, Sijbrand Hofker, Hein G Gooszen, Djamila Boerma, Marc G Besselink
BACKGROUND: Cholecystectomy after gallstone pancreatitis may be technically demanding. The aim of this study was to investigate risk factors for a difficult cholecystectomy after mild pancreatitis. METHODS: This was a prospective study within a randomized controlled trial on the timing of cholecystectomy after mild gallstone pancreatitis. Difficulty of cholecystectomy was scored on a 0 to 10 visual analogue scale (VAS) by the senior attending surgeon. The primary outcome 'difficult cholecystectomy' was defined by presence of one or more of the following features: a VAS score ≥ 8, duration of surgery > 75 minutes, conversion or subtotal cholecystectomy...
December 8, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Wiriyaporn Ridtitid, Santi Kulpatcharapong, Panida Piyachaturawat, Phonthep Angsuwatcharakon, Pradermchai Kongkam, Rungsun Rerknimitr
BACKGROUND: Early cholecystectomy (EC) is recommended in patients with acute biliary pancreatitis (ABP). In real-life practice, cholecystectomy is frequently deferred due to various reasons and delayed cholecystectomy (DC) is performed instead. Endoscopic sphincterotomy (ES) is an alternative to prevent recurrent pancreatitis, however other gallstone-related complications (GCs) may still develop. We aimed to determine the impact of ES on future GCs in patients with non-severe acute biliary pancreatitis whose cholecystectomy was deferred or not performed...
December 7, 2018: Surgical Endoscopy
Jaime Nieto-Zermeño, Ricardo Ordorica Flores, Blanca Del Río-Navarro, Betzabé Salgado-Arroyo, Jorge Mario Molina-Díaz
Introduction: Obesity is a world pandemic; in Mexico 3 out of 10 adolescents suffer from it. Conservative management of morbid obesity is not effective and bariatric surgery is the only useful therapy. International pediatric bariatric surgery series are scarce and in Mexico there is limited experience. Method: We analyze the metabolic repercussions, comorbidities and complications in our series of Mexican adolescents with morbid obesity who underwent a gastric sleeve between 2011 and 2015...
2018: Gaceta Médica de México
S V Kharitonov, I B Rannev, S S Kharitonov
AIM: To analyze informative value of radiological diagnosis of acute gallstone ileus. MATERIAL AND METHODS: There were 7 patients with acute gallstone ileus who underwent diagnostic abdominal X-ray examination, ultrasonography and computed tomography. RESULTS: There was high informative value of CT for acute gallstone ileus if it was applied within the first hours after admission. At the same time other diagnostic approaches were less informative...
2018: Khirurgiia
Li Chen, Chao Huang, Zhuo Chen
Depression is a mental disease that causes severe economic and social burdens. The mechanism for the onset of depression remains largely unknown. Recently, more and more attention is being given to the role of neuroinflammation and oxidative stress in depression. Tauroursodeoxycholic acid (TUDCA), a clinically available agent used to treat cholesterol gallstone and protect neurons against neurodegeneration, has been reported to prevent neuroinflammation and oxidative stress. In this study, we investigated the effect of TUDCA on lipopolysaccharide (LPS)-induced depression-like behavior, neuroinflammation, and oxido-nitrosative stress in mice...
December 5, 2018: Pharmacology
Fei Wang, Jing Wang, Yaru Li, Jing Yuan, Ping Yao, Sheng Wei, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Presence of gallstone disease (GSD) was reported to be positively associated with diabetes risk. Whether the association is causal remains unclear. We aim to examine the potential causal association between GSD and type 2 diabetes risk using a Mendelian randomization analysis. Observational study was conducted among 16,299 participants who were free of cancer, heart disease, stroke, and diabetes at baseline in the Dongfeng-Tongji cohort study. GSD was diagnosed by experienced physicians by abdominal B-type ultrasound inspection and type 2 diabetes was defined according to the criteria of the American Diabetes Association...
December 4, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Edson Gonçalves Ferreira Junior, Philippos Apolinario Costa, Larissa Melo Freire Golveia Silveira, Rafael Valois Vieira, Hugo Alessi Lima Martins Soares, Bruna Menon Loureiro, Nayane Carolina Pertile Salvioni, Jose Roberto Coelho Ferreira Rocha
INTRODUCTION: Castleman disease (CD) is a rare polyclonal lymphoproliferative disorder of unknown etiology, which usually develops in the mediastinum. It can also occur in the cervical, retroperitoneal and axillary regions. Localized pancreatic CD is quite rare [1]. PRESENTATION OF CASE: The authors herein present a case of a 34 years old female that was diagnosed during a symptomatic cholelithiasis evaluation. During the evaluation, an abdominal ultrasonography revealed a tumor at the head of the pancreas, which went on to generate a dilatation of the extrahepatic bile ducts...
November 20, 2018: International Journal of Surgery Case Reports
Ali Güngör, Neşe Yaralı, Ali Fettah, İkbal Ok-Bozkaya, Namık Özbek, Abdurrahman Kara
Güngör A, Yaralı N, Fettah A, Ok-Bozkaya İ, Özbek N, Kara A. Hereditary spherocytosis: Retrospective evaluation of 65 children. Turk J Pediatr 2018; 60: 264-269. Hereditary spherocytosis (HS) is a common cause of congenital hemolytic anemia in Caucasians and it could be diagnosed at any age. The aim of this study is to examine the demographic characteristics, clinical features and laboratory findings of children with HS and their complications observed during follow up. Sixty-five patients, with hereditary spherocytosis between January 2008 and September 2013, were enrolled into this retrospective study...
2018: Turkish Journal of Pediatrics
Yong Zhou, Wen-Zhang Zha, Ren-Gen Fan, Guo-Qin Jiang, Xu-Dong Wu
BACKGROUND: there is an increasing incidence rate of cholecysto-choledocholithiasis associated with the increasing proportion of senile individuals. METHODS: a total of 100 elderly patients (over 80 years of age) suffering both from cholelithiasis and choledocholithiasis were retrospectively studied from January 2010 to December 2016. Patients were scheduled for either a single-stage or two-stage procedure. The LCBDE group (n = 54) included cases that underwent a single stage procedure of laparoscopic exploration of the common bile duct combined with cholecystectomy...
December 3, 2018: Revista Española de Enfermedades Digestivas
Egil Ferkingstad, Asmundur Oddsson, Solveig Gretarsdottir, Stefania Benonisdottir, Gudmar Thorleifsson, Aimee M Deaton, Stefan Jonsson, Olafur A Stefansson, Gudmundur L Norddahl, Florian Zink, Gudny A Arnadottir, Bjarni Gunnarsson, Gisli H Halldorsson, Anna Helgadottir, Brynjar O Jensson, Ragnar P Kristjansson, Gardar Sveinbjornsson, David A Sverrisson, Gisli Masson, Isleifur Olafsson, Gudmundur I Eyjolfsson, Olof Sigurdardottir, Hilma Holm, Ingileif Jonsdottir, Sigurdur Olafsson, Thora Steingrimsdottir, Thorunn Rafnar, Einar S Bjornsson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, Patrick Sulem, Kari Stefansson
Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased risk of gallstone disease (Pro290Ser: OR = 1...
November 30, 2018: Nature Communications
Faisal Jehan, Muhammad Khan, Narong Kulvatunyou, Mohammad Hamidi, Lynn Gries, Muhammad Zeeshan, Terence O'Keeffe, Bellal Joseph
BACKGROUND: The aim of our study was to evaluate outcomes in patients who are admitted on weekend compared with those admitted on a weekday for acute gallstone pancreatitis. METHODS: We performed a 3-y (2010-2012) analysis of the Nationwide Inpatient Sample database. Patients with acute gallstone pancreatitis who underwent endoscopic retrograde cholangiopancreatography (ERCP) were included and were divided into two groups: admission on the weekend versus the weekday...
January 2019: Journal of Surgical Research
Deepak Dhamnetiya, Manish Kumar Goel, BalRaj Dhiman, Om Prakash Pathania
INTRODUCTION: Gallstone disease (GSD) represents a significant burden for health-care systems worldwide and is one of the most common disorders among patients presenting to emergency rooms with abdominal discomfort. This study was aimed to know the association of biochemical parameters and development of GSD. MATERIALS AND METHODS: We conducted a case-control study from January 2013 to December 2013 among patients attending outpatient department of general surgery at a tertiary care hospital of Delhi, North India; we recruited 120 cases and the same number of controls in the study...
October 2018: Journal of Laboratory Physicians
Harmeet Singh Mashiana, Amaninder Singh Dhaliwal, Harlan Sayles, Banreet Dhindsa, Ji Won Yoo, Qing Wu, Shailender Singh, Ali A Siddiqui, Gordon Ohning, Mohit Girotra, Douglas G Adler
AIM: To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography (ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events. METHODS: We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017...
November 16, 2018: World Journal of Gastrointestinal Endoscopy
Dimitri Poddighe, Vitaliy Sazonov
Acute acalculous cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. AAC is estimated to represent at least 50% to 70% of all cases of acute cholecystitis during childhood. Although this pathology was originally described in critically ill or post-surgical patients, most pediatric cases have been observed during several infectious diseases. In addition to cases caused by bacterial and parasitic infections, most pediatric reports after 2000 described children developing AAC during viral illnesses (such as Epstein-Barr virus and hepatitis A virus infections)...
November 21, 2018: World Journal of Gastroenterology: WJG
M I Talukder, M H Khan, F Chowdhury, A A Ansary, K Rahman, N Islam
Laparoscopic cholecystectomy is the gold standard in the treatment of gallstones. This study was carried out to determine the technical difficulties that can be encountered during laparoscopic cholecystectomy and to evaluate the role of ultrasonography in identifying patients at risk of conversion returning to open surgery. The objective of this study was to evaluate the efficacy of preoperative ultrasonography in assessing technical difficulty faced during laparoscopic cholecystectomy in gallstone disease...
October 2018: Mymensingh Medical Journal: MMJ
Yun-Xiao Lyu, Yun-Xiao Cheng, Hang-Fei Jin, Xin Jin, Bin Cheng, Dian Lu
BACKGROUND: The timing of laparoscopic cholecystectomy (LC) performed after the mild acute biliary pancreatitis (MABP) is still controversial. We conducted a review to compare same-admission laparoscopic cholecystectomy (SA-LC) and delayed laparoscopic cholecystectomy (DLC) after mild acute biliary pancreatitis (MABP). METHODS: We systematically searched several databases (PubMed, EMBASE, Web of Science, and the Cochrane Library) for relevant trials published from 1 January 1992 to 1 June 2018...
November 29, 2018: BMC Surgery
Rafael Gaszynski, Christopher Lim, Daniel L Chan, Oliver M Fisher, Kamala Kanta Das, Neil Merrett, Robert Wilson, Peter Cosman
BACKGROUND: Symptomatic cholelithiasis accounts for a significant burden of emergency general surgical presentations in Australia and the Western population. Access to hepatobiliary ultrasonography to facilitate diagnosis can lead to delays in timely treatment. Surgical ultrasonography at the bedside (SUB) can mitigate this barrier to patient care. This study assessed the diagnostic accuracy of SUB by trainees versus formal ultrasonographer or computed tomography examination for suspected symptomatic cholelithiasis...
November 28, 2018: ANZ Journal of Surgery
Umesh Panwar, Sanjeev Kumar Singh
BACKGROUND: Obesity is well known multifactorial disorder towards the public health concern in front of the world. Increasing rates of obesity has characterized with liver diseases, chronic diseases, diabetes mellitus, hypertension, and stroke, hearts improper function, reproductive and gastrointestinal, gallstones. An essential enzyme pancreatic lipase recognized for the digestion and absorption of lipids, can be a pleasing drug target towards the future development of anti-obesity therapeutics in cure of obesity disorders...
November 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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