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https://www.readbyqxmd.com/read/29134712/characterization-of-forced-degradation-products-of-canagliflozine-by-lc-qtof-ms-ms-and-in-silico-toxicity-predictions
#1
Shandilya Mahamuni Baira, Pradipbhai D Kalariya, Rakesh Nimbalkar, Prabha Garg, R Srinivas, M V N Kumar Talluri
RATIONALE: Forced degradation studies are useful for better understanding of the stability of active pharmaceutical ingredients and drugs and to generate information about drug degradation pathways and formation of degradation products (DPs). Identification of DPs plays a vital role in establishing the safety and therapeutic benefit of the drug. METHODS: Canagliflozin (CAN) was subjected to different stress conditions as per ICH guidelines (Q1A R2). All the DPs and the drug were well separated on Aquity CSH C18 (100 × 2...
November 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29126083/hplc-uv-ms-method-application-for-the-separation-of-obeticholic-acid-and-its-related-compounds-in-development-process-and-quality-control
#2
Michal Douša, Markéta Slavíková, Tomáš Kubelka, Josef Černý, Petr Gibala, Josef Zezula
An HPLC method with UV and electrospray ionization - mass spectrometry (ESI-MS) detection was developed for the separation and determination of obeticholic acid (OBE) and its related compounds in development process and quality control. OBE and its related compounds were classified into three major group based on the mass spectra profiles: (A) those containing a hydroxyl group at position 3 and 7, (B) those containing a hydroxyl group and/or carbonyl group at position 3, hydrogen, ethyl or ethylidene group at position 6 and a hydroxyl group and/or carbonyl group at position 7, and (C) those containing carbonyl groups at position 3 and 7...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29124408/ms-caspt2-study-of-the-ground-and-low-lying-states-of-csh
#3
Ján Škoviera, Ivan Černušák, Florent Louis, Pavel Neogrády
Correlated ab initio methods [CASPT2 and R-CCSD(T)] in conjunction with the ANO-RCC basis sets in large contraction were used to calculate potential energy curves (PECs) of the ground and excited electronic states of CsH(+) (doublets and quartets) with the inclusion of the scalar relativistic effects and spin-orbit interaction. The ground X(2)Σ(+) state is a rather fragile van der Waals molecular ion. The binding energy of this X(2)Σ(+) state provided by both computational methods is estimated to be 0.02-0...
November 9, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29120489/in-vitro-chemosensitivity-of-feline-injection-site-associated-sarcoma-cell-lines-to-carboplatin
#4
Elizabeth A Maxwell, Heidi Phillips, David J Schaeffer, Timothy M Fan
OBJECTIVE: To determine the in vitro chemosensitivity of feline injection site-associated sarcoma (FISAS) cells to carboplatin concentrations generated by elution of carboplatin-impregnated calcium sulfate hemihydrate (CI-CSH) beads. STUDY DESIGN: In vitro study. SAMPLE: Five immortalized cell lines from histologically confirmed, primary FISASs. METHODS: For each cell line, one 96-well microplate was used for each time point (24, 48, 72 hours)...
November 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29079452/use-of-sodium-trimetaphosphate-in-the-inhibition-of-dentin-matrix-metalloproteinases-and-as-a-remineralizing-agent
#5
Rafael Simões Gonçalves, Polliana Mendes Candia Scaffa, Marina Ciccone Giacomini, Marília Afonso Rabelo Buzalaf, Heitor Marques Honório, Linda Wang
OBJECTIVES: Because of its ability to act as an antiproteolytic agent, the effect of sodium trimetaphosphate (STMP) against specific enzymes extracted from sound dentin and its performance under acidic challenge on demineralized dentin were investigated. METHODS: The antiproteolytic potential of STMP (0.5%, 1.0%, and 1.5%) was assessed in triplicate by zymography. For the evaluation of remineralization activity, 50 bovine-root dentin specimens were selected and randomly divided into 5 groups (n=10)...
October 24, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29076415/antiepileptic-drugs-for-preventing-seizures-in-patients-with-chronic-subdural-hematoma
#6
Pedro Moura Branco, Bernardo Oliveira Ratilal, João Costa, Cristina Sampaio
Chronic subdural hematoma (CSH) is an accumulation of blood within the intracranial subdural space. It is associated with minor traumatic events and affects mostly the elderly. CSH can be effectively treated surgically with good outcomes, although the recurrence rate is high. Epileptic seizures are one of the major complications associated with CSH, either in the pre or postoperative period. The incidence rate of new onset seizures after CSH diagnosis ranges between 3% and 23%. However, the benefit of using prophylactic antiepileptic drugs in these patients is controversial with significant variations in clinical practice...
October 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29074342/the-use-of-endoscopic-assisted-burr-hole-craniostomy-for-septated-chronic-subdural-haematoma-a-retrospective-cohort-comparison-study
#7
Jibo Zhang, Xuemeng Liu, Xingyue Fan, Kai Fu, Chengshi Xu, Qin Hu, Pucha Jiang, Jincao Chen, Wei Wang
OBJECTIVE: To complete a retrospective comparison of endoscope-assisted burr-hole craniostomy (EBHC) and ordinary burr-hole craniostomy (OBHC) in the treatment of septated chronic subdural hematoma (SCSH). METHODS: A retrospective case note review comparing EBHC and OBHC of SCSH was therefore performed. Data of patients with a SCSH for EBHC or OBHC during the period from January 2011 to December 2016 were retrospectively collected and analysed. Of 73 patients, 42 underwent EBHC and 31 patients were treated by OBHC...
October 23, 2017: Brain Research
https://www.readbyqxmd.com/read/29066384/development-of-a-validated-hplc-method-for-the-quantitative-determination-of-trelagliptin-succinate-and-its-related-substances-in-pharmaceutical-dosage-forms
#8
Zhiqiang Luo, Xinjing Chen, Guopeng Wang, Zhibo Du, Xiaoyun Ma, Hao Wang, Guohua Yu, Aoxue Liu, Mengwei Li, Wei Peng, Yang Liu
Trelagliptin succinate is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM). In the present study, a rapid, sensitive and accurate high-performance liquid chromatography (HPLC) method was developed and validated for separation and determination of trelagliptin succinate and its eight potential process-related impurities. The chromatographic separation was achieved on a Waters Xselect CSH™ C18 (250mm×4.6mm, 5.0μm) column...
October 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29055193/specific-bioanalytical-optical-and-photoelectrochemical-assays-for-detection-of-methanol-in-alcoholic-beverages
#9
Javier Barroso, Beatriz Díez-Buitrago, Laura Saa, Marco Möller, Nerea Briz, Valeri Pavlov
Methanol is a poison which is frequently discovered in alcoholic beverages. Innovative methods to detect methanol in alcoholic beverages are being constantly developed. We report for the first time a new strategy for the detection of methanol using fluorescence spectroscopy and photoelectrochemical (PEC) analysis. The analytical system is based on the oxidation of cysteine (CSH) with hydrogen peroxide (H2O2) enzymatically generated by alcohol oxidase (AOx). H2O2 oxidizes capping agent CSH, modulating the growth of CSH-stabilized cadmium sulphide quantum dots (CdS QDs)...
October 13, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29045485/alterations-in-the-placental-methylome-with-maternal-obesity-and-evidence-for-metabolic-regulation
#10
Kohzoh Mitsuya, Ashley N Parker, Lu Liu, Jianhua Ruan, Margreet C M Vissers, Leslie Myatt
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous tissue was collected following cesarean section from lean (prepregnancy BMI<25) or obese (BMI>30) women...
2017: PloS One
https://www.readbyqxmd.com/read/29038360/carotid-sinus-hypersensitivity-block-of-the-sternocleidomastoid-muscle-does-not-affect-responses-to-carotid-sinus-massage-in-healthy-young-adults
#11
Matthew G Lloyd, James M Wakeling, Michael S Koehle, Robert J Drapala, Victoria E Claydon
The arterial baroreflex is crucial for short-term blood pressure control - abnormal baroreflex function predisposes to syncope and falling. Hypersensitive responses to carotid baroreflex stimulation using carotid sinus massage (CSM) are common in older adults and may be associated with syncope. The pathophysiology of this hypersensitivity is unknown, but chronic denervation of the sternocleidomastoid muscles is common in elderly patients with carotid sinus hypersensitivity (CSH), and is proposed to interfere with normal integration of afferent firing from the carotid baroreceptors with proprioceptive feedback from the sternocleidomastoids, producing large responses to CSM...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29026996/does-personality-influence-learning-a-case-study-in-an-invasive-lizard
#12
Melinda Chung, Celine T Goulet, Marcus Michelangeli, Brooke Melki-Wegner, Bob B M Wong, David G Chapple
Learning is a change in state resulting from new experiences enabling behavioural responses to be adjusted in alignment with external cues. Individuals differ in the speed and accuracy at which they learn. Personality has been postulated as being a major influence on learning ability in terms of attention and encounter rates of environmental cues. This link forms the basis of the cognitive style hypothesis (CSH), predicting that an individual's cognitive style will occur along a fast-slow behavioural gradient...
December 2017: Oecologia
https://www.readbyqxmd.com/read/28991997/substituting-ground-woody-plants-for-cottonseed-hulls-in-lamb-feedlot-diets-growth-performance-blood-serum-chemistry-and-rumen-fluid-parameters
#13
T R Whitney, J L Glasscock, J P Muir, W C Stewart, E J Scholljegerdes
Effects of using ground woody plants in Rambouillet wether lamb feedlot diets on growth performance, blood serum, and rumen parameters were evaluated. A randomized design study was used with 2 feeding periods (70% concentrate diet from d 0 to 27 [Period 1] and 86% concentrate diet from d 28 to 57 [Period 2]); the concentrate portion of the diets mainly consisted of dried distiller's grains with solubles and sorghum grain. Lambs were individually fed 6 diets that differed only by roughage source ( = 8 animals/treatment; 32...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28985540/influence-of-lead-on-stabilization-solidification-by-ordinary-portland-cement-and-magnesium-phosphate-cement
#14
Yan-Shuai Wang, Jian-Guo Dai, Lei Wang, Daniel C W Tsang, Chi Sun Poon
Inorganic binder-based stabilization/solidification (S/S) of Pb-contaminated soil is a commonly used remediation approach. This paper investigates the influences of soluble Pb species on the hydration process of two types of inorganic binders: ordinary Portland cement (OPC) and magnesium potassium phosphate cement (MKPC). The environmental leachability, compressive strength, and setting time of the cement products are assessed as the primary performance indicators. The mechanisms of Pb involved in the hydration process are analyzed through X-ray diffraction (XRD), hydration heat evolution, and thermogravimetric analyses...
September 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28962771/an-engineered-platform-based-on-chitin-affinity-immobilization-for-producing-low-molecular-weight-heparin
#15
Shuqin Xu, Xuanyue Zhang, Bo Duan, Jinghua Chen
Using chitin-affinity interaction between triple-functional heparinase I (Hep I) and chitin, an engineered platform was prepared to produce controllable low molecular weight heparin (LMWH). Chitin microspheres with well-defined nanofibrils were fabricated through a "bottom up" pathway. An enhanced soluble protein, ChBD-SUMO-Hep I (CSH-I), was expressed in 3L batch fermentation with a high bioactivity of 2.5×10(3) IU/L. Chitin binding domain (ChBD) can specifically bind to chitin in noncovalent way, which leads to the immobilization and purification of enzyme in a single step...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28953598/the-impact-of-scleral-contact-lens-vault-on-visual-acuity-and-comfort
#16
Heinz Otchere, Lyndon Jones, Luigina Sorbara
PURPOSE: To assess how varying degrees of corneal clearance of scleral contact lenses (ScCL) impact visual acuity (VA) and comfort in patients with corneal ectasia. METHOD: Three ScCL were fitted to 20 subjects with previous diagnosis of either keratoconus (n=18) or pellucid marginal degeneration (n=2). Fitting of ScCL was based on corneal sagittal height (CSH) measured with Visante OCT at a 15-mm chord on the horizontal meridian. To select the ScCL from the diagnostic lens set, values of 325, 375, and 425 μm were randomly added in sequence to CSH...
September 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28943669/effect-of-low-concentration-rhamnolipid-biosurfactant-on-pseudomonas-aeruginosa-transport-in-natural-porous-media
#17
Guansheng Liu, Hua Zhong, Yongbing Jiang, Mark L Brusseau, Jiesheng Huang, Liangsheng Shi, Zhifeng Liu, Yang Liu, Guangming Zeng
The effect of low-concentrations of monorhamnolipid biosurfactant on transport of Pseudomonas aeruginosa ATCC 9027 in natural porous media (silica sand and a sandy soil) was studied with miscible-displacement experiments using artificial groundwater as the background solution. Transport of two types of cells was investigated, glucose- and hexadecane-grown cells with lower and higher cell surface hydrophobicity (CSH), respectively. The effect of hexadecane presence as a residual non-aqueous phase liquid (NAPLs) on transport was also examined...
January 2017: Water Resources Research
https://www.readbyqxmd.com/read/28932362/clinical-radiological-pathological-correlation-of-cavernous-sinus-hemangioma-incremental-value-of-diffusion-weighted-imaging
#18
Abhishek Mahajan, Vedula Rajni Kanth Rao, Gudipati Anantaram, Ashwin M Polnaya, Sandeep Desai, Paresh Desai, Rammohan Vadapalli, Manas Panigrahi
AIM: To elucidate the clinical, magnetic resonance imaging (MRI), pathological features of these lesions and asses the incremental value of diffusion-weighted imaging (DWI) in diagnosing them. METHODS: Fifteen consecutive patients (11 females and 4 males; mean age 40.93 years; age range 13-63 years) with cavernous sinus hemangiomas (CSH) who underwent examination between November 2008 and May 2016 were included for the analysis. MRI, clinical and surgical findings of each patient was retrospectively reviewed...
August 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28915937/ultra-high-performance-supercritical-fluid-chromatography-mass-spectrometry-procedure-for-analysis-of-monosaccharides-from-plant-gum-binders
#19
Volodymyr Pauk, Tomáš Pluháček, Vladimír Havlíček, Karel Lemr
The ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC/MS) procedure for analysis of native monosaccharides was developed. Chromatographic conditions were investigated to separate a mixture of four hexoses, three pentoses, two deoxyhexoses and two uronic acids. Increasing water content in methanol modifier to 5% and formic acid to 4% improved peak shapes of neutral monosaccharides and allowed complete elution of highly polar uronic acids in a single run. An Acquity HSS C18SB column outperformed other three tested stationary phases (BEH (silica), BEH 2-ethylpyridine, CSH Fluoro-Phenyl) in terms of separation of isomers and analysis time (4...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28902479/support-for-healthy-eating-at-schools-according-to-the-comprehensive-school-health-framework-evaluation-during-the-early-years-of-the-ontario-school-food-and-beverage-policy-implementation
#20
Taryn Orava, Steve Manske, Rhona Hanning
INTRODUCTION: Provincial, national and international public health agencies recognize the importance of school nutrition policies that help create healthful environments aligned with healthy eating recommendations for youth. School-wide support for healthy living within the pillars of the comprehensive school health (CSH) framework (social and physical environments; teaching and learning; healthy school policy; and partnerships and services) has been positively associated with fostering improvements to student health behaviours...
September 2017: Health Promotion and Chronic Disease Prevention in Canada
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