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https://www.readbyqxmd.com/read/30115462/cost-analysis-of-chronic-intestinal-failure
#1
Emilio Canovai, Laurens J Ceulemans, Guido Peers, Lutgart De Pourcq, Marleen Pijpops, Gert De Hertogh, Martin Hiele, Jacques Pirenne, Tim Vanuytsel
BACKGROUND & AIMS: Chronic intestinal failure is a complex medical condition which is associated with high costs. These patients require long-term home parenteral nutrition (HPN) and costs are compounded by frequent admissions for the underlying disease and HPN. However, it is unknown what the specific costs subdivisions are and how they evolve over time. The aim of the study was to evaluate the cost dynamics of HPN care in a cohort of stable, long-term intestinal failure patients...
August 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/30114637/safety-evaluation-anti-oxidative-and-anti-inflammatory-effects-of-subchronically-dietary-supplemented-high-dosing-grape-seed-powder-gsp-to-healthy-rat
#2
Kamel Charradi, Mohamed Mahmoudi, Takwa Bedhiafi, Khawla Jebari, Michèle Veronique El May, Ferid Limam, Ezzedine Aouani
Grape seed powder (GSP) contains high amount of bioactive polyphenols usually used as nutritional supplement or food preservatives due to their antioxidant and scavenging properties. The purpose of the present work was to evaluate the safety of increasing dosage GSP (w/w) of 0.5%, 5%, 10% and 20% corresponding to 0.4, 4, 8 and 16 g/kg bw respectively, when administered sub-chronically to Wistar rats in a 2 month-repeated dosing oral toxicity trial. Overally GSP had no effect on food intake, decreased body weight gain without affecting brain, liver, heart or kidney relative weight...
August 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30112217/beyond-statins-emerging-evidence-for-hdl-increasing-therapies-and-diet-in-treating-cardiovascular-disease
#3
REVIEW
Sterling Farrer
Coronary heart disease continues to be the leading cause of death in the United States. Current attempts to treat atherosclerosis and coronary artery disease often involve pharmaceutical and surgical treatments. While these treatments are successful in managing the pain from coronary heart disease, they do little to prevent or stop it. There are a number of clinical strategies that are currently being researched to treat atherosclerosis through HDL-increasing therapies. These clinical studies have shown positive effects through nutritional intervention, exercise, stress reduction, and tobacco and alcohol cessation...
2018: Advances in Preventive Medicine
https://www.readbyqxmd.com/read/30110395/association-between-caga-negative-helicobacter-pylori-status-and-nonalcoholic-fatty-liver-disease-among-adults-in-the-united-states
#4
Seung Joo Kang, Hwa Jung Kim, Donghee Kim, Aijaz Ahmed
We investigated the relationship of H. pylori stratified by cytotoxin-associated gene A (cagA) status with nonalcoholic fatty liver disease (NAFLD) in the general population of the United States (US). We utilized the Third National Health and Nutrition Examination Survey from 1988 to 1994 in this study. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other known causes of liver diseases and significant alcohol consumption. Hepatic steatosis was assessed by parenchymal brightness, liver to kidney contrast, deep beam attenuation, bright vessel walls and gallbladder wall definition...
2018: PloS One
https://www.readbyqxmd.com/read/30109842/complex-lipid-globules-in-early-life-nutrition-improve-long-term-metabolic-phenotype-in-intra-uterine-growth-restricted-rats
#5
Inga C Teller, Heike Hoyer-Kuhn, Hella Brönneke, Pia Nosthoff-Horstmann, Annemarie Oosting, Gregor Lippach, Maria Wohlfarth, Manfred Rauh, Eline M van der Beek, Jörg Dötsch, Kai D Nüsken
Intra-uterine growth restriction (IUGR) is associated with adverse metabolic outcome later in life. Healthy mice challenged with a Western-style diet (WSD) accumulated less body fat when previously fed a diet containing large lipid globules (complex lipid matrix (CLM)). This study was designed to clarify whether an early-life CLM diet mitigates 'programmed' visceral adiposity and associated metabolic sequelae after IUGR. In rats, IUGR was induced either by bilateral uterine vessel ligation (LIG) or sham operation (i...
August 15, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/30109419/metabolic-alterations-associated-with-maternal-undernutrition-during-the-first-half-of-gestation-lead-to-a-diabetogenic-state-in-the-rat
#6
María Limones, Julio Sevillano, María G Sánchez-Alonso, Emilio Herrera, María Del Pilar Ramos-Álvarez
BACKGROUND: Although recent studies have investigated the effect of maternal nutrition on metabolic programming of the offspring, the question whether a nutritional insult during early gestation favours an altered metabolic state of the mother that persists during the remainder period of pregnancy, when foetal growth is maximal, remains to be answered. METHODS: To address this issue, we analysed the effect of 40% food restriction during the first 12 days of gestation on glucose tolerance, as well as on liver and adipose tissue metabolism, in Sprague-Dawley pregnant rats...
August 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/30105002/ghrelin-and-its-receptors-in-gilthead-sea-bream-nutritional-regulation
#7
Miquel Perelló-Amorós, Emilio J Vélez, Jaume Vela-Albesa, Albert Sánchez-Moya, Natàlia Riera-Heredia, Ida Hedén, Jaume Fernández-Borràs, Josefina Blasco, Josep A Calduch-Giner, Isabel Navarro, Encarnación Capilla, Elisabeth Jönsson, Jaume Pérez-Sánchez, Joaquim Gutiérrez
Ghrelin is involved in the regulation of growth in vertebrates through controlling different functions, such as feed intake, metabolism, intestinal activity or growth hormone (Gh) secretion. The aim of this work was to identify the sequences of preproghrelin and Ghrelin receptors ( ghsrs ), and to study their responses to different nutritional conditions in gilthead sea bream ( Sparus aurata ) juveniles. The structure and phylogeny of S. aurata preproghrelin was analyzed, and a tissue screening was performed...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30104891/high-prevalence-of-hypervirulent-klebsiella-pneumoniae-infection-in-the-genetic-background-of-elderly-patients-in-two-teaching-hospitals-in-china
#8
Chao Liu, Jiaojiao Shi, Jun Guo
Purpose: Aerobactin is a critical factor for hypervirulent Klebsiella pneumoniae (hvKp) in genetic backgrounds, but data based on the genotype for the elderly is limited. Materials and methods: A retrospective study was conducted on elderly patients from June 2008 to July 2017 in 2 teaching hospitals. The clinical and microbiological data, including antimicrobial susceptibility testing, string test, extended-spectrum β-lactamase (ESBL) production, virulence gene, and multilocus sequence typing, of the hvKp group defined as aerobactin positive were compared with those of classic K...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30104181/neurotensin-contributes-to-pediatric-intestinal-failure-associated-liver-disease-via-regulating-intestinal-bile-acids-uptake
#9
Yongtao Xiao, Weihui Yan, Ying Lu, Kejun Zhou, Wei Cai
Although the pathogenesis of intestinal failure (IF)-associated liver disease (IFALD) is uncertain, IF-associated cholestasis mediated by the combination of intestinal injury and parenteral nutrition (PN) can lead to disturbed hepatocyte bile acids (BA) homeostasis and cause liver damages. We here show that neurotensin (NT; also known as NTS) concentrations were lower compared to healthy matched controls. Patients with cholestasis [56.1 ng/L (9.7-154.7) vs. 210.4 ng/L (134-400.4), p < .001] had lower serum NT concentrations than others...
August 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/30100836/epidemiology-and-risk-factors-for-multidrug-resistant-bacteria-in-critically-ill-patients-with-liver-disease
#10
Anirban Hom Choudhuri, Priyanka Khurana, Partha Sarathi Biswas, Rajeev Uppal
Background and Aims: The critically ill patients with liver disease are vulnerable to infections in both community and hospital settings. The nosocomial infections are often caused by multidrug-resistant (MDR) bacteria. The present observational study was conducted to describe the epidemiology, course, and outcome of MDR bacterial infection and identify the risk factors of such infection in critically ill patients with liver disease. Materials and Methods: A retrospective observational study was conducted on 106 consecutive critically patients with liver disease admitted in the Intensive Care Unit between March 2015 and February 2017...
July 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/30098547/allyl-methyl-sulfide-an-organosulfur-compound-alleviates-hyperglycemia-mediated-hepatic-oxidative-stress-and-inflammation-in-streptozotocin-induced-experimental-rats
#11
Kathiroli Sujithra, Subramani Srinivasan, Dhananjayan Indumathi, Veerasamy Vinothkumar
Therapeutic approaches based on dietary compounds obtained from food products to handle diabetes involving oxidative stress and inflammation. Garlic is a common spice and has a long history as a folk remedy. Allyl methyl sulfide (AMS) is a potential garlic-derived organosulfur compound displaying a substantial range of optimistic actions in various diseases. Herein, we investigated the potential role of AMS in ameliorating the effects of oxidative stress and inflammation in the liver of streptozotocin (STZ)-induced experimental rats...
August 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30098534/polystyrene-microplastics-alter-the-behavior-energy-reserve-and-nutritional-composition-of-marine-jacopever-sebastes-schlegelii
#12
Liyun Yin, Bijuan Chen, Bin Xia, Xiaotao Shi, Keming Qu
Uptake and toxicity of microplastics on marine organisms have been reported elsewhere. However, there is limited knowledge regarding the ecological effects of microplastics on marine organisms. In this study, we investigated the effects of polystyrene microplastics (1 × 106 microspheres per L) on the behavior, energy reserve and nutritional composition of juvenile jacopever (Sebastes schlegelii). Compared to the controls, fish treated by microplastics showed lower sensitivity toward the added food in the tank, and increased foraging time, indicating that microplastics significantly weakened feeding activity of the fish...
August 3, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30098021/enteral-nutrition-for-maintenance-of-remission-in-crohn-s-disease
#13
REVIEW
Anthony K Akobeng, Dongni Zhang, Morris Gordon, John K MacDonald
BACKGROUND: Prevention of relapse is a major issue in the management of quiescent Crohn's disease (CD). Current therapies (e.g. methotrexate, biologics, 6-mercaptopurine and azathioprine) may be effective for maintaining remission in CD, but these drugs may cause significant adverse events. Interventions that are effective and safe for maintenance of remission in CD are desirable. OBJECTIVES: The primary objectives were to evaluate the efficacy and safety of enteral nutrition for the maintenance of remission in CD and to assess the impact of formula composition on effectiveness...
August 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30095152/nutritional-status-in-frail-cirrhotic-patients-undergoing-liver-transplantation
#14
D Azzolino, S Damanti, M Cesari
No abstract text is available yet for this article.
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/30082212/preoperative-prealbumin-level-as-an-independent-predictor-of-long-term-prognosis-after-liver-resection-for-hepatocellular-carcinoma-a-multi-institutional-study
#15
Ju-Dong Li, Xin-Fei Xu, Jun Han, Han Wu, Hao Xing, Chao Li, Jiong-Jie Yu, Ya-Hao Zhou, Wei-Min Gu, Hong Wang, Ting-Hao Chen, Yong-Yi Zeng, Wan Y Lau, Meng-Chao Wu, Feng Shen, Tian Yang
BACKGROUND: Serum prealbumin is a sensitive and stable marker for nutritional status and liver function. Whether preoperative prealbumin level is associated with long-term prognosis in patients undergoing liver resection for hepatocellular carcinoma (HCC) is unclear. METHODS: Patients who underwent liver resection for HCC between 2001 and 2014 at six institutions were enrolled. These patients were divided into the low and normal prealbumin groups using a cut-off value of 170 mg/L for preoperative prealbumin level...
August 3, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/30081587/association-between-serum-liver-enzymes-and-metabolic-syndrome-in-korean-adults
#16
Hae Ran Kim, Mi Ah Han
The purpose of this study was to evaluate the association between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and metabolic syndrome (MS) in the Korean population. A total of 11,587 adults ≥30 years of age and with complete data were selected from Korea National Health and Nutrition Examination Survey VI conducted from 2013 to 2015. Normal ALT and AST levels were divided into quartiles, and their associations with MS were assessed by logistic regression analysis. Elevated levels of ALT [adjusted odds ratio (aOR) = 7...
August 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30080956/liver-transplantation-for-propionic-acidemia-and-methylmalonic-acidemia-peri-operative-management-and-clinical-outcomes
#17
Kristen Critelli, Patrick McKiernan, Jerry Vockley, George Mazariegos, Robert H Squires, Kyle Soltys, James E Squires
Propionic acidemia (PA) and methylmalonic acidemia (MMA) comprise the most common organic acidemias and account for profound morbidity in affected individuals. While liver transplant has emerged as a bulk enzyme-replacement strategy to stabilize metabolically fragile patients, it is not a metabolic cure as patients remain at risk for disease-related complications. We retrospectively studied liver transplant and/or liver-kidney transplant in 9 patients with PA or MMA with additional focus on the optimization of metabolic control and management in the peri-operative period...
August 6, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/30079314/relationship-between-serum-tumor-related-markers-and-dietary-intakes-in-korean-healthy-adults
#18
Mi-Hyun Kim, Mi-Kyeong Choi
The purpose of this study was to investigate the relationship between serum tumor markers and dietary intakes in healthy adults to address a nutrition guide for cancer prevention. We analyzed tumor-related markers, carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), prostate-specific antigen (PSA), and cancer antigen 125 (CA125) in serum and daily food and nutrient intakes using a 24-hour recall method in 23 healthy men and 32 healthy women. The average age was 50.7 years for men and 48.9 years for women...
July 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/30078110/sonographic-features-of-umbilical-catheter-related-complications
#19
Swathi Selvam, Terry Humphrey, Helen Woodley, Sharon English, Jeannette K Kraft
Umbilical catheters are commonly used in the neonatal period for blood sampling or for administering medication or parenteral nutrition. The position of the catheter is usually confirmed with radiography. However, many complications associated with the use of umbilical catheters, such as liver collections from extravasation or vascular thrombosis, are not apparent on radiographs but can be easily diagnosed with ultrasound. This pictorial review illustrates the sonographic findings of complications that should be excluded in the sick neonate with an indwelling catheter...
August 4, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/30077528/plasma-trans-fatty-acid-and-risk-of-nonalcoholic-fatty-liver-disease-new-data-from-national-health-and-nutrition-examination-survey-nhanes
#20
EDITORIAL
Alessandro Mantovani
No abstract text is available yet for this article.
July 31, 2018: International Journal of Cardiology
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