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Temperature sensitive liposome

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https://www.readbyqxmd.com/read/30022700/temperature-sensitive-liposomes-for-codelivery-of-tamoxifen-and-imatinib-for-synergistic-breast-cancer-treatment
#1
Anup Jose, Kunal Manoj Ninave, Sriravali Karnam, Venkata Vamsi Krishna Venuganti
Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), monopalmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (MPPC) and different surface active agents. The liposomes were characterized for the average particle size, zeta-potential, transition temperature and drug release below and above liposomal transition temperature...
July 19, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29992403/preparation-of-folic-acid-targeted-temperature-sensitive-magnetoliposomes-and-their-antitumor-effects-in-vitro-and-in-vivo
#2
Xihui Wang, Rui Yang, Chunyan Yuan, Yanli An, Qiusha Tang, Daozhen Chen
BACKGROUND: Ovarian cancer is a common gynecologic malignancy with poor prognosis, requiring innovative new therapeutic strategies. Temperature-controlled drug delivery to cancer cells represents a novel, promising, targeted treatment approach. OBJECTIVE: We prepared folate receptor-targeted thermosensitive liposomes wrapped with the HSP90 inhibitor 17-AAG and superparamagnetic material (17-AAG/MTSLs-FA), and tested the efficacy of these targeted magnetoliposomes in vitro and in vivo...
July 10, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29972159/production-of-dynamic-lipid-bilayers-using-the-reversible-thiol-thioester-exchange-reaction
#3
Danielle Konetski, Sudheendran Mavila, Chen Wang, Brady Worrell, Christopher N Bowman
Thiol lysolipids undergo thiol-thioester exchange with two phenyl thioester-functionalized tails to produce phospholipid structures that assemble into liposomes with differences in exchange rates, temperature sensitivity, permeability, and continued exchange behavior. This in situ formation reaction imparts dynamic characteristics into the membrane for downstream liposome functionalization and mimics native membrane remodeling.
July 17, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29964133/the-effect-of-light-sensitizer-localization-on-the-stability-of-indocyanine-green-liposomes
#4
Tatu Lajunen, Riikka Nurmi, Danny Wilbie, Teemu Ruoslahti, Niklas G Johansson, Ossi Korhonen, Tomasz Rog, Alex Bunker, Marika Ruponen, Arto Urtti
Light triggered drug delivery systems offer attractive possibilities for sophisticated therapy, providing both temporal and spatial control of drug release. We have developed light triggered liposomes with clinically approved indocyanine green (ICG) as the light sensitizing compound. Amphiphilic ICG can be localized in different compartments of the liposomes, but the effect of its presence, on both triggered release and long term stability, has not been studied. In this work, we report that ICG localization has a significant effect on the properties of the liposomes...
June 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29914261/disruption-of-tumor-cells-using-a-ph-activated-and-thermosensitive-antitumor-lipopeptide-containing-a-leucine-zipper-structure
#5
Sijia Wang, Tong Wang, Junqi Zhang, Shouhong Xu, Honglai Liu
Antitumor peptides may potentially alleviate the problem of chemoresistance but do not yet target tumor cells and would be cytotoxic to normal cells. Here, we designed a pH-activated and thermosensitive lipopeptide (C6-Pep) containing a leucine zipper and an alkyl chain and assessed the ability of C6-Pep to kill cancer cells. Pep, the same sequence without the N-terminal hexanoic acid moiety, was generated as a less hydrophobic control. First, lipopeptide adsorption into lipid monolayers was studied using Langmuir-Blodgett and polarization modulation infrared reflection adsorption spectroscopy...
July 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29793337/thermosensitive-lipid-bilayer-coated-mesoporous-carbon-nanoparticles-for-synergistic-thermochemotherapy-of-tumor
#6
Xian Li, Xiudan Wang, Luping Sha, Da Wang, Wei Shi, Qinfu Zhao, Siling Wang
Thermochemotherapy exhibits a synergistic therapeutic efficiency for cancer, and the sensitivity of cancer cells to chemical drugs could be increased to a large extent at elevated temperature. In this work, a biocompatible nanocomposite thermosensitive mesoporous carbon nanoparticles (TSMCN) was prepared by covering a liposome on mesoporous carbon nanoparticles (MCN). The TSMCN had good photothermal efficiency and photostability. The doxorubicin (DOX)-loaded TSMCN (DOX/TSMCN) showed a slower release than the DOX-loaded MCN-COOH (DOX/MCN-COOH) both in simulated tumor environment and physiological environment...
June 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29768884/coating-chitosan-thin-shells-a-facile-technique-to-improve-dispersion-stability-of-magnetoliposomes
#7
Thi Tuong Vy Phan, Madhappan Santha Moorthy, Hyun Wook Kang, Seung Yun Nam, Yong Wook Lee, Junghwan Oh
Magnetoliposomes (ML) have been emerging as a novel multifunctional nanoparticle with a wide range of biomedical and therapeutic applications over the past decade. Although the ML system has shown excellent performances, the stability and lipid peroxidation of liposomal components are still remaining as key issues and need to be solved for intensive applications. Changing zeta potential of nanoparticles' surface can be seen as a potential way to achieve the stable dispersion. In this work, we have employed the positive charged, abundant and cheap chitosan to coat ML in order to change the zeta potential of the ML system and examined the stability of chitosan@magnetoliposomes (CML) in long-term storage...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29688083/localized-delivery-of-therapeutic-doxorubicin-dose-across-the-canine-blood-brain-barrier-with-hyperthermia-and-temperature-sensitive-liposomes
#8
Amy Lee Bredlau, Anjan Motamarry, Chao Chen, M A McCrackin, Kris Helke, Kent E Armeson, Katrina Bynum, Ann-Marie Broome, Dieter Haemmerich
Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transiently opens the BBB, we hypothesized that localized hyperthermia can achieve drug delivery across the BBB when combined with TSL. TSL-encapsulated doxorubicin (TSL-Dox) was infused intravenously over 30 min at a dose of 0...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29671386/k237-modified-thermosensitive-liposome-enhanced-the-delivery-efficiency-and-cytotoxicity-of-paclitaxel-in-vitro
#9
Xudong Fu, Yuanyuan Lu, Jiaping Guo, Hui Liu, Aiping Deng, Changchun Kuang, Xiangyang Xie
This study aimed to develop novel temperature-sensitive liposomes loading paclitaxel (PTX-TSL) and evaluate them in vitro to improve the delivery efficiency and targeting of PTX. K237 peptide was conjugated to the terminal NHS of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[hydroxyl succinimidyl (polyethylene glycol)-(DSPE-PEG-NHS), and K237-modified PTX-TSL (K237-PTX-TSL) was prepared using a film dispersion method. K237-TSL encapsulation with calcein was synthesized and used to determine the cellular uptake of TSL...
April 19, 2018: Journal of Liposome Research
https://www.readbyqxmd.com/read/29522832/formation-of-protein-corona-in-vivo-affects-drug-release-from-temperature-sensitive-liposomes
#10
Zahraa S Al-Ahmady, Marilena Hadjidemetriou, James Gubbins, Kostas Kostarelos
Thermally triggered drug release from temperature-sensitive liposomes (TSL) holds great promise for cancer therapy. Different types of TSL have been designed recently for heat triggered drug release inside tumor blood vessels or after accumulation into the tumor interstitium. However, justification of drug release profiles is for far mainly based on in vitro release data. While these methods could be good enough to give early indication about the thermal sensitivity of TSL, they are still far from being optimum...
April 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29498309/temperature-sensitive-liposomal-ciprofloxacin-for-the-treatment-of-biofilm-on-infected-metal-implants-using-alternating-magnetic-fields
#11
Imalka Munaweera, Sumbul Shaikh, Danny Maples, Adane S Nigatu, Sri Nandhini Sethuraman, Ashish Ranjan, David E Greenberg, Rajiv Chopra
Implants are commonly used as a replacement for damaged tissue. Many implants, such as pacemakers, chronic electrode implants, bone screws, and prosthetic joints, are made of or contain metal. Infections are one of the difficult to treat complications associated with metal implants due to the formation of biofilm, a thick aggregate of extracellular polymeric substances (EPS) produced by the bacteria. In this study, we treated a metal prosthesis infection model using a combination of ciprofloxacin-loaded temperature-sensitive liposomes (TSL) and alternating magnetic fields (AMF)...
March 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29462757/unveiling-the-ph-dependent-interaction-between-bolaamphiphiles-dicarboxylic-acids-and-c-10-tab-decyltrimethylammonium-bromide-in-aqueous-medium
#12
Animesh Pan, Subhash C Bhattacharya, Animesh K Rakshit, Satya P Moulik
Development of stable self-assembled nanostructures (especially vesicles and liposomes), and understanding their physicochemical behaviors in aqueous solution is a long-standing topic of interest in chemical and biochemical research. In this progressive area, we report for the first-time formation of mixed micelles (at pH 12), and vesicles of anionic bolaamphiphiles (dicarboxylic acids viz. [Formula: see text] , with moderate values of n 10, 11, 12, and 14) in combination with a cationic surfactant decyltrimethylammonium bromide (C10 TAB) in buffered aqueous medium at different pH (6...
May 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29462688/hierarchical-drug-release-of-ph-sensitive-liposomes-encapsulating-aqueous-two-phase-system
#13
Xunan Zhang, Wei Zong, Hongmei Bi, Kunming Zhao, Thomas Fuhs, Ying Hu, Wenlong Cheng, Xiaojun Han
As promising drug delivery vehicles, previous investigations of liposomes as carriers are primarily focused on insertion and modification of lipid membrane interfaces. The utility of inner core seems to be overlooked. Herein, we developed PSLs containing aqueous two phase system (ATPS), and intriguingly discovered their hierarchical release under acidic stimuli. ATPS containing two polymers (poly(ethylene glycol) (PEG) and dextran) is homogeneous beyond phase transition temperature when producing ATPS-liposomes, and separated into PEG-rich phase and dextran-rich phase after cooling down to room temperature...
February 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29410222/effective-light-triggered-contents-release-from-helper-lipid-incorporated-liposomes-co-encapsulating-gemcitabine-and-a-water-soluble-photosensitizer
#14
Toshiki Fuse, Tatsuaki Tagami, Masafumi Tane, Tetsuya Ozeki
Triggered drug release is a promising strategy for delivering anticancer drugs to cancer cells and tissues. We found that liposomes co-encapsulating calcein (a water-soluble model drug and fluorescence marker) and talaporfin sodium (TPS, a water-soluble photosensitizer) released the drug upon irradiation with a near-infrared (NIR)-laser. The liposomes were composed of phospholipid (DSPC)/helper lipid (DOPE)/cholesterol/PEG-lipid (PEG2000 -DSPE) at a molar ratio of 85/10/5/5 and released a large amount of drug (70%<, within 10 min) upon irradiation, but no drug in the absence of NIR-laser irradiation and/or TPS...
April 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29325469/current-update-of-a-thermosensitive-liposomes-composed-of-dppc-and-brij78
#15
Laurence Ho, Mehrdad Bokharaei, Shyh-Dar Li
Thermosensitive liposomes (TSLs) have been a prominent area of study in the discipline of tumour-targeted chemotherapeutics. The representative product of TSLs is ThermoDox® (DPPC/lyso-PC/PEG-lipid), which has advanced to Phase III clinical trials. Various groups have sought to develop a new TSL to improve upon the LTSL (lyso-lipid temperature-sensitive liposomes) formulation that is used to prepare ThermoDOX® . This review focuses on the development and recent update of an innovative TSL formulation, HaT-liposomes composed of DPPC and Brij78...
June 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29284329/drug-release-kinetics-of-temperature-sensitive-liposomes-measured-at-high-temporal-resolution-with-a-millifluidic-device
#16
Caitlin Burke, Matthew R Dreher, Ayele H Negussie, Andrew S Mikhail, Pavel Yarmolenko, Aakash Patel, Brenden Skilskyj, Bradford J Wood, Dieter Haemmerich
PURPOSE: Current release assays have inadequate temporal resolution ( ∼ 10 s) to characterise temperature sensitive liposomes (TSL) designed for intravascular triggered drug release, where release within the first few seconds is relevant for drug delivery. MATERIALS AND METHODS: We developed a novel release assay based on a millifluidic device. A 500 µm capillary tube was heated by a temperature-controlled Peltier element. A TSL solution encapsulating a fluorescent compound was pumped through the tube, producing a fluorescence gradient along the tube due to TSL release...
December 28, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29278945/elastin-like-polypeptide-incorporated-thermally-sensitive-liposome-improve-antibiotic-therapy-against-musculoskeletal-bacterial-pathogens
#17
Adane S Nigatu, Harshini Ashar, Sri Nandhini Sethuraman, Rachel Wardlow, Danny Maples, Jerry Malayer, Ashish Ranjan
Musculoskeletal infections caused by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa in children and adults can lead to adverse outcomes including a need for extensive surgical debridement and limb amputation. To enable targeted antimicrobial release in infected tissues, the objective of this study was to design and investigate novel elastin-like polypeptide (ELP)-based thermally sensitive liposomes in vitro. ELP biopolymers can change their phase behaviour at higher temperatures. We hypothesised that ELP-TSL will improve therapeutic efficacy by releasing antimicrobial payloads locally at higher temperatures (≥39 °C)...
March 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29167602/rapid-reversible-release-from-thermosensitive-liposomes-triggered-by-near-infra-red-light
#18
Natalie Forbes, Alessia Pallaoro, Norbert O Reich, Joseph A Zasadzinski
We present a novel drug carrier consisting of plasmonic hollow gold nanoshells (HGN) chemically tethered to liposomes made temperature sensitive with lysolipids (LTSL). Continuous-wave irradiation by physiologically friendly near infra-red light at 800 nm for 2.5 minutes at laser intensities an order of magnitude below that known to damage skin generates heating localized to the liposome membrane. The heating increases the liposome permeability in an irradiation dose-dependent, but reversible manner, resulting in rapid release of small molecules such as the self-quenching dye carboxyfluorescein or the chemotherapeutic doxorubicin, without raising the bulk temperature...
November 2014: Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems
https://www.readbyqxmd.com/read/29032194/in-situ-mucoadhesive-thermosensitive-liposomal-gel-as-a-novel-vehicle-for-nasal-extended-delivery-of-opiorphin
#19
Paola Mura, Natascia Mennini, Cristina Nativi, Barbara Richichi
Previous studies proved the effectiveness of an intravenous PEGylated liposomal formulation of opiorphin (1mg/mL) in protecting the drug from enzymatic degradation, and improving intensity and duration of its painkilling effect. Therefore, considering the advantages of nasal administration, the aim of this work was the development of a liposomal mucoadhesive thermo-sensitive in situ gel for the extended nasal delivery of opiorphin. With this purpose, the potential of a series of combinations of different polymers (i...
January 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28972792/a-nano-liposome-vaccine-carrying-e75-a-her-2-neu-derived-peptide-exhibits-significant-antitumour-activity-in-mice
#20
Atefeh Arab, Javad Behravan, Atefeh Razazan, Zahra Gholizadeh, Amin Reza Nikpoor, Nastaran Barati, Fatemeh Mosaffa, Ali Badiee, Mahmoud Reza Jaafari
E75 (HER-2/neu-369-377), is an immunogenic peptide which is highly expressed in breast cancer patients. The purpose of this study was to develop an effective vaccine delivery/adjuvant system by attachment of this peptide to the surface of liposomes consisting of phospholipids including distearoylphosphocholine (DSPC) and distearoyl phosphoglycerol (DSPG) with high transition temperature (Tm) and dioleoylphosphatidylethanolamine (DOPE) (a pH-sensitive lipid for cytosolic antigen delivery) to improve antitumour immune activity against the E75 peptide...
April 2018: Journal of Drug Targeting
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