Syed Saqib Ali Zaidi, Faria Fatima, Syed Aqib Ali Zaidi, Dezhong Zhou, Wuquan Deng, Shuai Liu
Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA) has approved multiple siRNA-based therapeutics, many biological barriers limit their use for treating diseases. Such limitations include challenges concerning systemic or local administration, short half-life, rapid clearance rates, nonspecific binding, cell membrane penetration inability, ineffective endosomal escape, pH sensitivity, endonuclease degradation, immunological responses, and intracellular trafficking...
October 18, 2023: Journal of Nanobiotechnology