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https://www.readbyqxmd.com/read/29141310/-analysis-of-gene-mutation-of-early-onset-epileptic-spasm-with-unknown-reason
#1
X Yang, G Pan, W H Li, L M Zhang, B B Wu, H J Wang, P Zhang, S Z Zhou
Objective: To summarize the gene mutation of early onset epileptic spasm with unknown reason. Method: In this prospective study, data of patients with early onset epileptic spasm with unknown reason were collected from neurological department of Children's Hospital of Fudan University between March 2016 and December 2016. Patients with known disorders such as infection, metabolic, structural, immunological problems and known genetic mutations were excluded. Patients with genetic disease that can be diagnosed by clinical manifestations and phenotypic characteristics were also excluded...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29140411/effect-of-angiotensin-ii-and-acth-on-adrenal-blood-flow-in-the-male-rat-adrenal-gland-in-vivo
#2
Abdul J Shah, Tamas Kriska, Kathryn M Gauthier, John R Falck, William B Campbell
Angiotensin II (Ang II) and adrenocorticotropic hormone (ACTH) regulate adrenal vascular tone in vitro through endothelial and/or zona glomeulosa cell-derived mediators. The role of these mediators in regulating adrenal blood flow (ABF) and mean arterial pressure (MAP) was examined in anesthetized rats. Ang II (0.01-100 ng/kg) increased ABF (maximal increase of 97.2 ± 6.9 perfusion units (PU) at 100 ng/kg) and MAP (basal, 115 ± 7 mm Hg; Ang II, 163 ± 5 mm Hg). ACTH (0.1-1000 ng/kg) also increased ABF (maximum increase of 91...
November 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29137015/malignant-transformation-of-a-mature-teratoma-of-the-adrenal-gland-a-rare-case-report-and-literature-review
#3
Miao Niu, Ailian Liu, Ying Zhao, Lu Feng
RATIONALE: Adrenal mature TMT is very rare. So far, only two cases have been reported. PATIENT: We report a rare case of malignant transformation of a mature teratoma in the right adrenal gland of a 36-year-old Chinese female. The patient had been asymptomatic until physical exam identified a palpable mass in the right abdomen. Abdominal non-enhanced computed tomography (CT) scan showed a huge tumor with mixed density in right adrenal region, which had cystic components, fat, calcifications, and separations...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135108/addressing-the-post-irradiation-hypothalamic-pituitary-endocrine-abnormalities-of-brain-tumors-in-pediatric-patients
#4
Louloudenia Velentza, Maria Tolia, Charikleia Christakou, Michail Nikolaou, Ioannis Zerdes, Nikolaos Tsoukalas, Jiannis Hajiioannou, Konstantinos Tsanadis, Georgios Rigas, Michail Mitsis, Kyriaki Theodorou, Kyriaki Pistevou-Gombaki, Periklis Tsekeris, George Kyrgias
PURPOSE: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors. METHODS: The data were collected by relevant studies on PubMed and EMBASE. Articles up to December 2016 were included. We selected studies which focused on children patients (<18 yr old) with brain tumors treated with radiotherapy and the consequences for their endocrine system...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29130715/relationship-of-long-term-macronutrients-intake-on-anabolic-catabolic-hormones-in-female-elite-volleyball-players
#5
Juan Mielgo Ayuso, Michael C Zpurdos, Aritz Urdampilleta, Julio Calleja González, Jesús Seco, Alfredo Córdova
INTRODUCTION: Specific macronutrient distribution and training can alter acute and chronic hormone behavior and, subsequently, sport performance. OBJECTIVE: The main aim was to examine relationships between dietary intake and anabolic/catabolic hormone response in elite female volleyball players during a 29-week season. METHODS: Twenty-two elite female volleyballers (26.4 ± 5.6 years; 178 ± 9 cm; 67.1 ± 7.5 kg) had dietary intake (seven-day dietary recall and food frequency questionnaire), blood concentration of anabolic/catabolic hormones concentration, physical performance, and body composition assessed at four time points: a) T1: baseline/pre-testing; b) T2: eleven weeks after T1; c) T3: ten weeks after T2; and d) T4: eight weeks after T3...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29128802/chronic-social-isolation-in-adaptation-of-hpa-axis-to-heterotypic-stress
#6
Anna Gądek-Michalska, Andrzej Bugajski, Joanna Tadeusz, Paulina Rachwalska, Jan Bugajski
BACKGROUND: Social crowding and isolation are recognized as major stressors and risk factors for development of psychiatric disorders. Chronic isolation stress (IS) and crowding stress (CS) activate neuroendocrine and neurochemical mechanisms, that activate the hypothalamic-pituitary-adrenal (HPA) axis. Changes of the plasma level of interleukin-1β (IL-1β), ACTH and corticosterone (CORT) after chronic psychosocial IS and CS were investigated. METHODS: Control rats were kept 5 per cage and not stressed...
November 9, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29127765/high-aldosterone-and-cortisol-levels-in-salt-wasting-congenital-adrenal-hyperplasia-a-clinical-conundrum
#7
Sirisha Kusuma Boddu, Sheeja Madhavan
BACKGROUND: Salt wasting syndrome (hyponatremia, hyperkalemia, dehydration, metabolic acidosis) in early infancy could be caused by either mineralocorticoid deficiency as in congenital adrenal hyperplasia (CAH) and adrenal insufficiency or mineralocorticoid resistance as in pseudohypoaldosteronism (PHA). In salt wasting CAH, serum aldosterone and cortisol levels are expected to be low. Cross reactivity between high levels of adrenal steroid precursors and aldosterone has recently been reported resulting in elevated aldosterone levels in CAH, leading to difficulty in differentiating between CAH and PHA...
November 11, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29126827/on-the-palms-of-his-hands-acth-induced-hyperpigmentation
#8
Skand Shekhar, Pramila Dharmshaktu
No abstract text is available yet for this article.
November 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29126147/adrenocorticotropin-acutely-regulates-pregnenolone-sulfate-production-by-the-human-adrenal-in-vivo-and-in-vitro
#9
Juilee Rege, Aya T Nanba, Richard J Auchus, Jianwei Ren, Hwei-Ming Peng, William E Rainey, Adina F Turcu
Background: Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in human circulation, and ACTH is considered the major regulator of its synthesis. Pregnenolone sulfate (PregS) and 5-Androstenediol-3-sulfate (AdiolS) have recently emerged as biomarkers of adrenal disorders. Objective: To define the relative human adrenal production of ∆5-steroid sulfates under basal and cosyntropin-stimulated conditions. Methods: Liquid chromatography-tandem mass spectrometry was used to quantify three unconjugated and four sulfated ∆5-steroids in: 1) paired adrenal vein (AV) and mixed venous serum samples (21 patients), and 2) cultured human adrenal cells, both before and after cosyntropin stimulation; 3) microdissected zona fasciculata (ZF) and zona reticularis (ZR) from 5 human adrenal glands; 4) reconstituted in vitro human 17α-hydroxylase/17,20-lyase (CYP17A1/ P450 17A1) system...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29122730/cerebral-venous-sinus-thrombosis-following-second-transsphenoidal-surgery-report-of-a-rare-complication-and-review-of-literature
#10
Zhuangzhuang Miao, Zhuo Zhang, Juan Chen, Junwen Wang, Huaqiu Zhang, Ting Lei
BACKGROUND: Cushing's disease, induced by pituitary adrenocorticotropic hormone (ACTH) secreting adenomas, is associated with high risk factors of stroke. At present, transsphenoidal surgery remains the first line of therapy. Cerebral venous sinus thrombosis (CVST) is an uncommon form of stroke with variable presentations but, to date, there have been no reports of its occurrence in Cushing's disease patients following surgery. CASE DESCRIPTION: We herein report a Cushing's disease case who suffered CVST a few days after a second transsphenoidal surgery...
November 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29122691/sexually-diergic-hypothalamic-pituitary-adrenal-axis-responses-to-selective-and-non-selective-muscarinic-antagonists-prior-to-cholinergic-stimulation-by-physostigmine-in-rats
#11
Marissa A Smail, Jessica L Soles, Tracy E Karwoski, Robert T Rubin, Michael E Rhodes
Central cholinergic systems regulate the hypothalamic-pituitary-adrenal (HPA) axis differentially in males and females (sexual diergism). We previously investigated the role of muscarinic receptors in this regulation by administering physostigmine (PHYSO), an acetylcholinesterase inhibitor, to male and female rats pretreated with scopolamine (SCOP), a nonselective muscarinic antagonist. SCOP pretreatment enhanced adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses in both sexes; males had greater ACTH responses while females had greater CORT responses...
November 7, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29122401/the-efficacy-of-adrenocorticotropic-hormone-in-a-girl-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#12
Mari Hatanaka, Shuichi Shimakawa, Akihisa Okumura, Jun Natsume, Miho Fukui, Shohei Nomura, Mitsuru Kashiwagi, Hiroshi Tamai
BACKGROUND: Immunomodulatory therapy has shown some therapeutic benefits in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. In this report, we describe the use of adrenocorticotropic hormone (ACTH) immunotherapy with good outcome in a patient with anti-NMDAR encephalitis. SUBJECT AND METHODS: A 4-year-old girl developed convulsions in her right arm and leg without impaired consciousness. These convulsions occurred frequently in clusters of 10-20 events of 10-20 s duration...
November 6, 2017: Brain & Development
https://www.readbyqxmd.com/read/29118987/massive-adrenal-incidentalomas-and-late-diagnosis-of-congenital-adrenal-hyperplasia-in-prostate-cancer
#13
Xin Feng, Gregory Kline
In a 61-year-old Caucasian male with prostate cancer, leuprolide and bicalutamide failed to suppress the androgens. He presented to endocrinology with persistently normal testosterone and incidental massive (up to 18 cm) bilateral adrenal myelolipomas on CT scan. Blood test did not reveal metanephrine excess. The patient was noted to have short stature (151 cm) and primary infertility. Elementary school photographs demonstrated precocious puberty. Physical examination revealed palpable abdominal (adrenal) masses...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29118985/acute-development-of-cushing-syndrome-in-an-hiv-infected-child-on-atazanavir-ritonavir-based-antiretroviral-therapy
#14
Gueorgui Dubrocq, Andrea Estrada, Shannon Kelly, Natella Rakhmanina
An 11-year-old male with perinatally acquired human immune deficiency virus (HIV) infection on antiretroviral regimen, which included abacavir plus lamivudine (Epzicom), didanosine, ritonavir and atazanavir presented with bilateral axillary striae, increased appetite, fatigue, facial swelling and acute weight gain. Two months prior to presentation, the patient had received a diagnostic and therapeutic intra-articular triamcinolone injection in the knee for pain relief and subsequently became progressively swollen in the face, developed striae bilaterally at the axillae, experienced increased appetite, fatigue and an 8 pound weight gain...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29115641/traumatic-stress-affects-alcohol%C3%A2-drinking-behavior-through-cocaine%C3%A2-and-amphetamine%C3%A2-regulated-transcript-55%C3%A2-102-in-the-paraventricular-nucleus-in-rats
#15
Jie Liu, Xue-Ming Hu, Xiao-Jian Li, Hui Zhao
Cumulative evidence has suggested an association between stress and alcohol self‑administration; however, less is known about the role of traumatic stress in alcohol drinking behavior. It has been reported that cocaine‑ and amphetamine‑regulated transcript (CART) 55‑102 may be involved in mediating stress responses and regulating reward and reinforcement. The aim of the present study was to evaluate the role of CART 55‑102 in alcohol drinking behavior of rats in the presence or absence of traumatic stress...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114273/formulation-and-characterization-of-nanomedicine-solid-lipid-nanoparticle-associate-with-the-extract-of-pterospermum-acerifolium-for-the-screening-of-neurochemicals-and-neuroendocrine-effects
#16
Ankur Choubey, Ritu Gilhotra, Santosh Kumar Singh, Gopal Garg
Background: Nanotechnology has given the likelihood of conveying medications to particular cells utilizing nanoparticles. Nanosystems can convey the dynamic constituent at an adequate fixation amid the whole treatment time frame, guiding it to the fancied site of activity. Traditional medications do not meet these necessities. The fundamental motivation behind creating elective medication conveyance advancements is to expand effectiveness of medication conveyance and security during the time spent medication conveyance and give more accommodation to the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29113582/the-effects-of-magnesium-sulfate-on-the-inflammatory-response-of-placentas-perfused-with-lipopolysaccharide-using-the-ex-vivo-dual-perfused-human-single-cotyledon-model
#17
Michal Kovo, Noa Mevorach-Zussman, Nizar Khatib, Yuval Ginsberg, Michael Divon, Zeev Weiner, Jacob Bar, Ron Beloosesky
OBJECTIVES: Multiple mechanisms have been proposed for the neuroprotective effects of magnesium sulfate (MgSO4). We aimed to examine the effects of lipopolysaccharide (LPS) and MgSO4 on the placental expression of nuclear factor κ light chain enhancer of activated B cells (NF-κB), interleukin (IL) 6, adrenocorticotropic hormone (ACTH), and nitric oxide synthase (NOS); all known to participate in the inflammatory cascade. METHODS: Placentas were obtained and selected cotyledons cannulated and dually perfused ex vivo...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29111782/circadian-profiles-of-progesterone-gonadotropins-cortisol-and-corticotropin-in-cycling-and-postmenopausal-women
#18
Anne Caufriez, Rachel Leproult, Georges Copinschi
Little is known about the regulation of temporal variations of progesterone over the 24-hr span in young cycling women as well as in postmenopausal women. The purpose of the present study was to investigate the relationships between diurnal variations of progesterone and diurnal variations of hormones of the gonadotropic and corticotropic axes, and to provide further information on the source of progesterone secretion under physiological conditions. Twenty-four-hour hormonal profiles were explored under well-controlled laboratory conditions in 10 healthy women (21-36 yr old) with normal ovulatory cycles during early-mid follicular and late luteal phases, and in 8 healthy postmenopausal women (48-74 yr old)...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29109870/acute-onset-panhypopituitarism-nearly-missed-by-initial-cosyntropin-testing
#19
Claudine A Blum, Daniel Schneeberger, Matthias Lang, Janko Rakic, Marc Philippe Michot, Beat Müller
Introduction: Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome. Case: A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was vasopressor-nonresponsive. Diabetes insipidus was diagnosed due to polyuria and treated with 4 mg desmopressin...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29108291/a-novel-total-pituitary-hormone-index-as-an-indicator-of-postoperative-pituitary-function-in-patients-undergoing-resection-of-pituitary-adenomas
#20
Shousen Wang, Biao Li, Chenyu Ding, Deyong Xiao, Liangfeng Wei
The purpose of this study was to investigate the differences between pre- and postoperative pituitary hormone levels in patients undergoing surgical resection of pituitary adenoma and to identify factors associated with preoperative hypopituitarism. Data from 81 patients with histologically confirmed functioning and non-functioning pituitary adenomas (NFPA) who underwent transsphenoidal resection from January 2011 to December 2013 were retrospectively analyzed. Logistic regression was applied to analyze factors associated with preoperative hypopituitarism...
October 3, 2017: Oncotarget
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