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https://www.readbyqxmd.com/read/29483645/erk5-is-activated-by-oncogenic-braf-and-promotes-melanoma-growth
#1
Ignazia Tusa, Sinforosa Gagliardi, Alessandro Tubita, Silvia Pandolfi, Carmelo Urso, Lorenzo Borgognoni, Jinhua Wang, Xianming Deng, Nathanael S Gray, Barbara Stecca, Elisabetta Rovida
Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments are still unsatisfactory. While the role of the BRAF-MEK1/2-ERK1/2 pathway in melanoma is well established, the involvement of mitogen-activated protein kinases MEK5-ERK5 remains poorly explored. Here we investigated the function of ERK5 signaling in melanoma...
May 2018: Oncogene
https://www.readbyqxmd.com/read/29396391/targeted-inhibition-of-hedgehog-gli-signaling-by-novel-acylguanidine-derivatives-inhibits-melanoma-cell-growth-by-inducing-replication-stress-and-mitotic-catastrophe
#2
Silvia Pietrobono, Roberta Santini, Sinforosa Gagliardi, Francesca Dapporto, David Colecchia, Mario Chiariello, Cosima Leone, Massimo Valoti, Fabrizio Manetti, Elena Petricci, Maurizio Taddei, Barbara Stecca
Aberrant activation of the Hedgehog (HH) signaling is a critical driver in tumorigenesis. The Smoothened (SMO) receptor is one of the major upstream transducers of the HH pathway and a target for the development of anticancer agents. The SMO inhibitor Vismodegib (GDC-0449/Erivedge) has been approved for treatment of basal cell carcinoma. However, the emergence of resistance during Vismodegib treatment and the occurrence of numerous side effects limit its use. Our group has recently discovered and developed novel and potent SMO inhibitors based on acylguanidine or acylthiourea scaffolds...
February 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/27373978/down-regulation-of-sox2-underlies-the-inhibitory-effects-of-the-triphenylmethane-gentian-violet-on-melanoma-cell-self-renewal-and-survival
#3
Silvia Pietrobono, Andrea Morandi, Sinforosa Gagliardi, Gianni Gerlini, Lorenzo Borgognoni, Paola Chiarugi, Jack L Arbiser, Barbara Stecca
Human melanomas contain a population of tumor-initiating cells that are able to maintain the growth of the tumor. We previously showed that the embryonic transcription factor SOX2 is essential for self-renewal and tumorigenicity of human melanoma-initiating cells. However, targeting a transcription factor is still challenging. Gentian violet (GV) is a cationic triphenylmethane dye with potent antifungal and antibacterial activity. Recently, a combination therapy of imiquimod and GV has shown an inhibitory effect against melanoma metastases...
October 2016: Journal of Investigative Dermatology
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