Christopher W Wasson, Enrico De Lorenzis, Eva M Clavane, Rebecca L Ross, Kieran A Walker, Begoña Caballero-Ruiz, Cristina Antinozzi, Rebecca Wells, Gemma Migneco, Jane M Y Brown, Samuel J Turvey, Katie J Simmons, Natalia A Riobo-Del Galdo, Luigi Di Luigi, Clive S McKimmie, Francesco Del Galdo, Paul J Meakin
The beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is well known for its role in the development of Alzheimer's disease. Recent publications, including our own, have demonstrated a role for this enzyme in other chronic diseases. The aim of this study was to investigate the role of BACE1 in the autoimmune disease systemic sclerosis (SSc). BACE1 protein levels were elevated in SSc patient skin. Inhibition of BACE1 with small molecule inhibitors or siRNA blocked SSc and fibrotic stimuli mediated fibroblast activation...
April 1, 2024: Journal of Investigative Dermatology