Ying Zhang, Dheeraj S Roy, Yi Zhu, Yefei Chen, Tomomi Aida, Yuanyuan Hou, Chenjie Shen, Nicholas E Lea, Margaret E Schroeder, Keith M Skaggs, Heather A Sullivan, Kyle B Fischer, Edward M Callaway, Ian R Wickersham, Ji Dai, Xiao-Ming Li, Zhonghua Lu, Guoping Feng
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with Parkinson's disease (PD), patients also experience motor learning impairments and non-motor symptoms such as depression1 . The neural circuit basis for these different symptoms of PD are not well understood. Although current treatments are effective for locomotion deficits in PD2,3 , therapeutic strategies targeting motor learning deficits and non-motor symptoms are lacking4-6 . Here we found that distinct parafascicular (PF) thalamic subpopulations project to caudate putamen (CPu), subthalamic nucleus (STN) and nucleus accumbens (NAc)...
July 2022: Nature