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Age related hearing loss

P Z Wu, L D Liberman, K Bennett, V de Gruttola, J T O'Malley, M C Liberman
The noise-induced and age-related loss of synaptic connections between auditory-nerve fibers and cochlear hair cells is well-established from histopathology in several mammalian species; however, its prevalence in humans, as inferred from electrophysiological measures, remains controversial. Here we look for cochlear neuropathy in a temporal-bone study of "normal-aging" humans, using autopsy material from 20 subjects aged 0 to 89 yrs, with no history of otologic disease. Cochleas were immunostained to allow accurate quantification of surviving hair cells in the organ Corti and peripheral axons of auditory-nerve fibers...
August 9, 2018: Neuroscience
Aurore Marie, Johann Meunier, Emilie Brun, Susanna Malmstrom, Veronique Baudoux, Elodie Flaszka, Gaëlle Naert, François Roman, Sylvie Cosnier-Pucheu, Sergio Gonzalez-Gonzalez
Age-related hearing loss (ARHL) is the most common sensory disorder in the elderly population. SAMP8 mouse model presents accelerated senescence and has been identified as a model of gerontological research. SAMP8 displays a progressive age-related decline in brain function associated with a progressive hearing loss mimicking human aging memory deficits and ARHL. The molecular mechanisms associated with SAMP8 senescence process involve oxidative stress leading to chronic inflammation and apoptosis. Here, we studied the effect of N-acetylcysteine (NAC), an antioxidant, on SAMP8 hearing loss and memory to determine the potential interest of this model in the study of new antioxidant therapies...
August 2018: Aging and Disease
Annie N Simpson, Lois J Matthews, Christy Cassarly, Judy R Dubno
OBJECTIVES: Although many individuals with hearing loss could benefit from intervention with hearing aids, many do not seek or delay seeking timely treatment after the onset of hearing loss. There is limited data-based evidence estimating the delay in adoption of hearing aids with anecdotal estimates ranging from 5 to 20 years. The present longitudinal study is the first to assess time from hearing aid candidacy to adoption in a 28-year ongoing prospective cohort of older adults, with the additional goal of determining factors influencing delays in hearing aid adoption, and self-reported successful use of hearing aids...
August 6, 2018: Ear and Hearing
Yuanyuan Wang, Tonya R Bergeson, Derek M Houston
Purpose: It is well established that (a) infants prefer listening to infant-directed speech (IDS) over adult-directed speech (ADS), and (b) IDS facilitates speech, language, and cognitive development, compared with ADS. The main purpose of this study was to determine whether infants with hearing aids (HAs), similar to their peers with normal hearing (NH), show a listening preference for IDS over ADS. Method: A total of 42 infants participated in the study. In Experiment 1, 9 infants with hearing loss, who had approximately 12 months of experience (mean chronological age of 17...
August 6, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
Michael Leon, Cynthia Woo
The human brain sustains a slow but progressive decline in function as it ages and these changes are particularly profound in cognitive processing. A potential contributor to this deterioration is the gradual decline in the functioning of multiple sensory systems and the effects they have on areas of the brain that mediate cognitive function. In older adults, diminished capacity is typically observed in the visual, auditory, masticatory, olfactory, and motor systems, and these age-related declines are associated with both a decline in cognitive proficiency, and a loss of neurons in regions of the brain...
2018: Frontiers in Behavioral Neuroscience
Paul Albert Fuchs, Amanda M Lauer
Cholinergic efferent neurons originating in the brainstem innervate the acoustico-lateralis organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit hair cells through activation of calcium-dependent potassium channels. In the mammalian cochlea, ACh shunts and suppresses outer hair cell (OHC) electromotility, reducing the essential amplification of basilar membrane motion. Consequently, medial olivocochlear neurons that inhibit OHCs reduce the sensitivity and frequency selectivity of afferent neurons driven by cochlear vibration of inner hair cells (IHCs)...
August 6, 2018: Cold Spring Harbor Perspectives in Medicine
Shauntelle A Cannon, Monita Chatterjee
OBJECTIVES: Emotional communication is important in children's social development. Previous studies have shown deficits in voice emotion recognition by children with moderate-to-severe hearing loss or with cochlear implants. Little, however, is known about emotion recognition in children with mild-to-moderate hearing loss. The objective of this study was to compare voice emotion recognition by children with mild-to-moderate hearing loss relative to their peers with normal hearing, under conditions in which the emotional prosody was either more or less exaggerated (child-directed or adult-directed speech, respectively)...
August 1, 2018: Ear and Hearing
Meryl Waldman, Joan C Han, Daniela P Reyes-Capo, Joy Bryant, Kathryn A Carson, Baris Turkbey, Peter Choyke, Jürgen K Naggert, William A Gahl, Jan D Marshall, Meral Gunay-Aygun
Alström Syndrome is a ciliopathy associated with obesity, insulin resistance/type 2 diabetes mellitus, cardiomyopathy, retinal degeneration, hearing loss, progressive liver and kidney disease, and normal cognitive function. ALMS1, the protein defective in this disorder, localizes to the cytoskeleton, microtubule organizing center, as well as the centrosomes and ciliary basal bodies and plays roles in formation and maintenance of cilia, cell cycle regulation, and endosomal trafficking. Kidney disease in this disorder has not been well characterized...
July 24, 2018: Molecular Genetics and Metabolism
Michael F Hoffman, Ivette Cejas, Alexandra L Quittner
OBJECTIVES: Severe to profound hearing loss is associated with worse health-related quality of life (HRQoL), reflecting the wide-ranging effects of deafness on spoken language, cognition, and social/behavioral development. However, there are currently no cochlear implant (CI)-specific HRQoL measures that were developed using the Food and Drug Administration Guidance on patient-reported outcomes. This study developed the first HRQoL instruments (CI-QoL) for children with CIs, ages 6 to 12, and a parent-proxy measure for this age group...
July 27, 2018: Ear and Hearing
Marta Maria Gorecka, Olena Vasylenko, Jacob Espenes, Knut Waterloo, Claudia Rodríguez-Aranda
This investigation assessed the impact of hearing loss and lateralized auditory attention on spatiotemporal parameters of gait during overground dual-tasking by the use of the dichotic listening task. Seventy-eight right-handed, healthy older adults between 60 and 88 years were assigned to a Young-Old (<70 years) or an Old-Old (>71 years) group. Cognitive assessment and pure tone audiometry were conducted. Spatiotemporal parameters of gait quantified by mean (M), and coefficient of variations (CoV) were evaluated with the OptoGait system during 3 dichotic listening conditions: Non-Forced, Forced-Right and Forced-Left...
July 26, 2018: Experimental Gerontology
Konstantinos Mourtzouchos, Maria Riga, Mario Cebulla, Vasilios Danielides, Stefanos Naxakis
OBJECTIVES: During the last twenty years, auditory steady-state responses (ASSRs) are being used as an alternative and adjunct to the auditory brainstem response (ABR) for threshold estimation. This study aims at comparing and finding correlations between air-conduction thresholds using the traditional click ABR and the relatively recently used chirp ASSR test methods, for a large pediatric population. METHODS: One hundred and thirty children referred to our Clinic from Hospitals and Clinics of Western Greece ranging in age from 5 to 79 months (mean age = 32...
September 2018: International Journal of Pediatric Otorhinolaryngology
Leticia Saia da Silva, Georgea Espindola Ribeiro, Jair Cortez Montovani, Daniela Polo Camargo da Silva
OBJECTIVE: To verify the effect of peri-intraventricular hemorrhage on the auditory pathway of preterm infants. METHOD: It is a non-concurrent cohort study. This study was conducted in a tertiary public. Preterm infants with peri-intraventricular hemorrhage comprised the study group, and preterm infants without peri-intraventricular hemorrhage were included as a comparison group, both were similar in relation to gestational age and risk indicators for hearing loss...
September 2018: International Journal of Pediatric Otorhinolaryngology
Burhan Balta, Ramazan Gundogdu, Murat Erdogan, Murat Alisik, Aslihan Kiraz, Ibrahim Ozcan, Ozcan Erel
INTRODUCTION: Oxidative stress plays a key role in the formation of age-related, noise-induced and drug-induced hearing loss. Thiols are organic compounds which can react with free radicals to protect against tissue and cell damage caused by reactive oxygen. There are no studies in literature on the association between autosomal recessive non-syndromic hearing loss(ARNSHL) including GJB2 and non-GJB2 mutations and thiol-disulphide balance. In this study, we aim to assess whether thiol-disulphide balance is disrupted in patients with ARNSHL...
September 2018: International Journal of Pediatric Otorhinolaryngology
Rose Marie Rine
This article focuses on vestibular rehabilitation (VR) for children. Reports of the presence of vestibular dysfunction in infants, young children, and adolescents have increased over the past decade. In addition to being a comorbidity of sensorineural hearing loss, vestibular dysfunction has been noted in children with cytomegalovirus, late prematurity, and concussion, to name a few. Despite ample evidence and reports of VR for adults, the selection and provision of exercises to be included in the VR protocol for children vary, depending on the nature of the lesion, impairments identified, age at the time of lesion, and developmental factors such as critical periods of development and intermodality interdependence...
August 2018: Seminars in Hearing
Hong Yu, Dan Liu, Jingqun Yang, Zhiqiang Wu
Mutations in the GJB2, SLC26A4, GJB3, and MT-RNR1 genes are known to be a common cause of hearing loss. However, the frequency of hot-spot mutations and genotype-phenotype correlations in patients with sensorineural hearing loss (SNHL) has been less frequently reported. We conducted a study of 103 children-56 boys and 47 girls, aged 5 months to 9 years (mean: 4.1 yr)-with SNHL who underwent genetic screening for 20 hot-spot mutations of the GJB2, SLC26A4, GJB3, and MT-RNR1 genes. Mutations were detected by multiple-PCR-based MALDI-TOF MS assay...
June 2018: Ear, Nose, & Throat Journal
Òscar Miró, Berenice Nayla Brizzi, Sira Aguiló, Xavier Alemany, Javier Jacob, Pere Llorens, Pablo Herrero Puente, Begoña González Ramón, Verónica Castro Jiménez, Victoria Torres Machado, Raquel Cenjor, Adriana Gil, Verònica Rico, Gemma Martínez Nadal, Montserrat Lázaro Del Nogal, Francisco Javier Martín-Sánchez
OBJECTIVES: To profile patients aged 65 years or older who are attended in a hospital emergency department after falls. To describe the falls, their severity, and factors relevant to recommended preventive measures. MATERIAL AND METHODS: The FALL-ER is a multipurpose, multicenter prospective registry of a systematically described cohort of patients aged 65 years or older attended in 5 hospital emergency departments on 52 days of the same year. We collected data on 68 independent variables...
2018: Emergencias: revista de la Sociedad Española de Medicina de Emergencias
Laura Jagoda, Nathalie Giroud, Patrick Neff, Andrea Kegel, Tobias Kleinjung, Martin Meyer
Individuals suffering from tinnitus often complain about difficulties understanding speech in noisy environments even in the absence of a peripheral hearing loss. This EEG study aimed to investigate whether aspects of phonetic perception are affected by the experience of tinnitus. We examined a sample of individuals with chronic, subjective tinnitus (n = 30, age range 30-50 yrs.), who underwent behavioural screening (standard tinnitus questionnaires) and comprehensive audiometric testing that covered peripheral and central hearing abilities (pure tone audiometry, suprathreshold audiometry (frequency selectivity and temporal compression), and speech in noise performance)...
July 5, 2018: Hearing Research
Bo Ding, Joseph P Walton, Xiaoxia Zhu, Robert D Frisina
Due to the critical role of cochlear ion channels for hearing, the focus of the present study was to examine age-related changes of Na, K-ATPase (NKA) subunits in the lateral wall of mouse cochlea. We combined qRT-PCR, western blot and immunocytochemistry methodologies in order to determine gene and protein expression levels in the lateral wall of young and aged CBA/CaJ mice. Of the seven NKA subunits, only the mRNA expressions of α1, β1 and β2 subunit isoforms were detected in the lateral wall of CBA/CaJ mice...
July 10, 2018: Hearing Research
Christian Füllgrabe, Aleksander P Sęk, Brian C J Moore
Differences in the temporal fine structure (TFS) of sounds at the two ears are used for sound localization and for the perceptual analysis of complex auditory scenes. The ability to process this binaural TFS information is poorer for older than for younger participants, and this may contribute to age-related declines in the ability to understand speech in noisy situations. However, it is unclear how sensitivity to binaural TFS changes across the older age range. This article presents data for a test of binaural sensitivity to TFS, the "TFS-adaptive frequency" (AF) test, for 118 listeners aged 60 to 96 years with normal or near-normal low-frequency hearing, but a variety of patterns of hearing loss at higher frequencies...
January 2018: Trends in Hearing
Linda R Wang, Aleksandar Radonjic, Allison A Dilliott, Adam D McIntyre, Robert A Hegele
Background. Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy (MDPL) syndrome is a recently recognized genetic disorder comprised of mandibular hypoplasia, deafness, progeroid features, and lipodystrophy. It is caused by an autosomal dominant mutation in the POLD1 gene, with <20 genetically confirmed cases to date. Clinical overlap with other progeroid syndromes including Werner syndrome (WS) can present diagnostic challenges. Case. The proband is a 36-year-old male of Sicilian ancestry who was phenotypically normal at birth...
January 2018: Journal of Investigative Medicine High Impact Case Reports
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