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Age related hearing loss

Bo Li, Tihua Zheng, Caifang Yan, Wenjun Wang, Jinjin Zhang, Luping Zhang, Juan Hu, Li Zhang, Yuzhu Wan, Minyan Zhang, Qingyin Zheng
We previously developed Cdh23 mutant mice (erl mice) as a model of hearing loss for otoprotective drug evaluation and showed that the erl mutation leads to hearing loss related to endoplasmic reticulum (ER) stress-induced cochlear hair cell apoptosis. Small molecular chemical chaperones, 4-phenylbutyrate (4PBA), targeting ER stress exert a neuroprotective effect. To evaluate whether 4PBA exerts an otoprotective effect, we intraperitoneally injected erl mice with 4PBA daily from postnatal age day 7 up to 12 weeks...
December 3, 2018: Neuroreport
Malgorzata Pawlaczyk-Luszczynska, Adam Dudarewicz, Małgorzata Zamojska-Daniszewska, Kamil Zaborowski, Paulina Rutkowska-Kaczmarek
Introduction: The overall objective of the study was to assess noise exposure and audiometric hearing threshold levels (HTLs) in call center operators. Materials and Methods: Standard pure-tone audiometry and extended high-frequency audiometry were performed in 78 participants, aged 19 to 44 years (mean ± standard deviation: 28.1 ± 6.3 years), employed up to 12 years (2.7 ± 2.9 years) at one call center. All participants were also inquired about their communication headset usage habits, hearing-related symptoms, and risk factors for noise-induced hearing loss (NIHL)...
September 2018: Noise & Health
Rui Yu, Chengwei Wang, Chuncheng Qu, Jun Jiang, Qinghu Meng, Ji Wang, Shengcheng Wei
OBJECTIVE: The aim of the study was to evaluate the efficacy of microvascular decompression (MVD) and stereotactic gamma knife surgery (GKS) in the treatment of trigeminal neuralgia (TN) in the elderly. PATIENTS AND METHODS: Retrospective analysis of 137 elderly cases with TN underwent MVD, partial sensory rhizotomy (PR) treatment from August 2007 to March 2017 and 56 cases underwent GKS treatment from May 2014 to February 2017 was made, compared the efficacy of MVD and GKS in different age groups...
November 30, 2018: Journal of Craniofacial Surgery
Christelle En Lin Chua, Bor Luen Tang
Epigenetic influence of brain and neuronal function plays key regulatory roles in health and diseases. The microRNA miR-34a is a tumor suppressor transcript, and its loss has been prominently linked to various human cancers, including malignancies of the brain. Interestingly, miR-34a is abundantly expressed in the adult mammalian brain, and emerging evidence has implicated its involvement in a range of neurodevelopmental and neuropathological processes. Developmentally, miR-34a regulates neural stem/progenitor cell differentiation and aspects of neurogenesis...
November 28, 2018: Journal of Molecular Neuroscience: MN
Erin M Picou, Gabrielle H Buono
The purpose of this study was to evaluate the relationship between emotional responses to sounds, hearing acuity, and isolation, specifically objective isolation (social disconnectedness) and subjective isolation (loneliness). It was predicted that ratings of valence in response to pleasant and unpleasant stimuli would influence the relationship between hearing loss and isolation. Participants included 83 adults, without depression, who were categorized into three groups (young with normal hearing, older with normal hearing, and adults with mild-to-moderately severe hearing loss)...
January 2018: Trends in Hearing
Grainne E Crealey, Ciaran O'Neill
Background: Hearing loss (HL) affects an estimated 17% of adults in Britain, 19% in Canada and 16% in the USA. Evidence points to the impact of HL on aspects of physical and mental health as well as autonomy, cognition, memory and social isolation. This suggests the relationship between HL and service use may arise indirectly as well as directly, an issue that warrants investigation. Methods: We used data from Health Survey for England (2014) on objectively and subjectively measured HL, mental and physical health as well as aspects of well-being related to autonomy, cognition, memory and social isolation within a series of bivariate probit models to examine the relationship between health and GP use in the past two weeks...
November 27, 2018: Journal of Public Health
Hanna Birkbak Hovaldt, Tine Nielsen, Jesper Dammeyer
Background and Objectives: Research has shown that dual sensory loss is a risk factor for depression in older adults. However, validated measures of depression for people with dual sensory loss are lacking. The purpose of the present study was to investigate the construct validity and reliability of the Major Depression Inventory for use among elderly persons with acquired dual sensory loss. Research Design and Methods: A cross-sectional questionnaire survey was conducted in a national sample of people ≥50 years of age with functional acquired dual sensory loss...
January 2018: Innovation in Aging
Jennifer McCullagh, Jennifer B Shinn
BACKGROUND: Older adults often report difficulty hearing in background noise which is not completely attributable to peripheral hearing loss. Although age-related declines in cognition and hearing in background noise occur, the underlying age-related changes in processing of auditory stimuli in background noise has yet to be fully understood. The auditory P300 has the potential to elucidate the effects of age on auditory and cognitive processing of stimuli in background noise, but additional research is warranted...
November 2018: Journal of the American Academy of Audiology
Meltem Genç, Bünyamin Çildir, Mesut Kaya
BACKGROUND: Assessing hearing aid satisfaction is important for hearing aid adaptation in individuals who have hearing loss. Each user should be compared to oneself during the adaptation of the hearing aid and the determination of the satisfaction level, because, each user has their own demands and expectations. Therefore, the survey evaluations which reveal the personal preferences and expectations gain importance in the determination of the benefit and satisfaction rate for hearing aid users...
November 2018: Journal of the American Academy of Audiology
YoungAh Youn, Soon Min Lee, Jong-Hee Hwang, Su Jin Cho, Ee-Kyung Kim, Ellen Ai-Rhan Kim
Background: The aim of this study was to observe long-term outcomes of very low birth weight infants (VLBWIs) born between 2013 and 2014 in Korea, especially focusing on neurodevelopmental outcomes. Methods: The data were collected from Korean Neonatal Network (KNN) registry from 43 and 54 participating units in 2013 and 2014, respectively. A standardized electronic case report form containing 30 items related to long-term follow up was used after data validation...
November 26, 2018: Journal of Korean Medical Science
Per Germundsson, Vinaya Manchaiah, Pierre Ratinaud, Aristotle Tympas, Berth Danermark
This study aims to understand patterns in the social representation of hearing loss reported by adults across different countries and explore the impact of different demographic factors on response patterns. The study used a cross-sectional survey design. Data were collected using a free association task and analysed using qualitative content analysis, cluster analysis and chi-square analysis. The study sample included 404 adults (18 years and over) in the general population from four countries (India, Iran, Portugal and UK)...
December 2018: International Journal of Audiology
Bo Engdahl, Mariann Idstad, Vegard Skirbekk
Hearing loss as well as being single has been associated with an increased risk of all-cause mortality. The purpose of the study is to assess whether being single or childless moderates the elevated risk of mortality in hearing impaired. The Nord-Trøndelag hearing Loss Study examined 50,462 persons above 20 years of age during 1996-1998. The Norwegian Cause of Death Registry was used to identify deaths until 2016. Data on marital status was obtained from the Norwegian Population Registry. Hearing loss was defined as the pure-tone average (0...
November 13, 2018: Social Science & Medicine
Vinaya Manchaiah, Harvey Abrams, Abram Bailey, Gerhard Andersson
BACKGROUND: The low uptake of hearing aids in the United States has been attributed to a number of reasons, including low perceived hearing disability, limited perceived benefit and cost. Another possible reason may be related to negative side effects associated with hearing aid use. PURPOSE: The present study was aimed at determining and classifying the negative side effects associated with hearing aid use in adults with hearing loss. RESEARCH DESIGN: The study used a cross-sectional survey design...
September 25, 2018: Journal of the American Academy of Audiology
Skylar Trott, Trey Cline, Jeffrey Weihing, Deidra Beshear, Matthew Bush, Jennifer Shinn
BACKGROUND: Estrogen has been identified as playing a key role in many organ systems. Recently, estrogen has been found to be produced in the human brain and is believed contribute to central auditory processing. After menopause, a low estrogen state, many women report hearing loss but demonstrate no deficits in peripheral hearing sensitivity, which support the notion that estrogen plays an effect on central auditory processing. Although animal research on estrogen and hearing loss is extensive, there is little in the literature on the human model...
September 23, 2018: Journal of the American Academy of Audiology
Erin M Picou, Todd A Ricketts
BACKGROUND: People with hearing loss experience difficulty understanding speech in noisy environments. Beamforming microphone arrays in hearing aids can improve the signal-to-noise ratio (SNR) and thus also speech recognition and subjective ratings. Unilateral beamformer arrays, also known as directional microphones, accomplish this improvement using two microphones in one hearing aid. Bilateral beamformer arrays, which combine information across four microphones in a bilateral fitting, further improve the SNR...
January 2, 2018: Journal of the American Academy of Audiology
Mary E Fischer, Karen J Cruickshanks, Lauren K Dillard, David M Nondahl, Barbara E K Klein, Ronald Klein, James S Pankow, Ted S Tweed, Carla R Schubert, Dayna S Dalton, Adam J Paulsen
BACKGROUND: Associations between vascular health-related factors and hearing loss defined using audiometric pure-tone thresholds have been found. Studies have not focused on a potential relationship between vascular health-related factors and central auditory processing. PURPOSE: The aim of this study was to evaluate, on a population level, the relationship of vascular health-related factors with central auditory function. RESEARCH DESIGN: A cross-sectional, population study...
February 13, 2018: Journal of the American Academy of Audiology
Elizabeth M Fitzpatrick, Isabelle Gaboury, Andrée Durieux-Smith, Doug Coyle, JoAnne Whittingham, Mina Salamatmanesh, Rachel Lee, Jessica Fitzpatrick
BACKGROUND: Amplification is considered to be one of the most important interventions for children with hearing loss. However, achieving consistent use of hearing technology in young children is an important problem, particularly when hearing loss is of mild degree. Little information is available about amplification use specifically for children with mild bilateral or unilateral hearing loss when such losses are targeted and identified early because of the availability of newborn hearing screening...
January 15, 2018: Journal of the American Academy of Audiology
Patrick N Plyler, Brittney Tardy, Mark Hedrick
BACKGROUND: Nonlinear frequency compression (NLFC) and digital noise reduction (DNR) are hearing aid features often used simultaneously in the adult population with hearing loss. Although each feature has been studied extensively in isolation, the effects of using them in combination are unclear. PURPOSE: The effects of NLFC and DNR in noise on word recognition and satisfaction ratings in noise in adult hearing aid users were evaluated. RESEARCH DESIGN: A repeated measures design was used...
December 21, 2017: Journal of the American Academy of Audiology
Haitao Shen, Weilin Liu, Qiaowei Geng, Hongchen Li, Mingshun Lu, Peng Liang, Bo Zhang, Ebenezer N Yamoah, Ping Lv
Age-related hearing loss (AHL) is the most common sensory disorder in the elderly population, and the etiologies are diverse. To understand the underlying mechanisms of AHL, one strategy is to identify correlates of the disease for comprehensive evaluation of treatment approaches. Dysfunction and degeneration of spiral ganglion neurons (SGNs) are major contributors to AHL. Previously, we showed that one of the changes in the aging auditory system is SGN excitability increase in mice. Since hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play important roles in determining neuronal excitability, we predicted that HCN channels in SGNs are involved in AHL...
2018: Frontiers in Aging Neuroscience
Susan M Gillingham, Antonino Vallesi, M Kathleen Pichora-Fuller, Claude Alain
Evidence from epidemiological, laboratory and clinical research suggests a link between age-related auditory declines and domain-general cognitive declines. Nevertheless, few studies have experimentally compared measures of non-auditory cognitive functions in younger normal hearing adults (YN), older adults with typical hearing thresholds for their age (ONHA) and older adults with clinically significant threshold hearing loss (OHL). The current study investigated the differences between these groups on measures of attentional response selection and execution to visual stimuli...
2018: Frontiers in Aging Neuroscience
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