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circRNA or "circular RNA"

Gang Liu, Kangmao Huang, Zhiwei Jie, Yizheng Wu, Junxin Chen, Zizheng Chen, Xiangqian Fang, Shuying Shen
BACKGROUND: There is an urgent need to identify new molecular targets for treatment of osteosarcoma. Circular RNAs are a class of endogenous RNAs that are extensively found in mammalian cells and exert critical functions in the regulation of gene expression, but in osteosarcoma the underlying molecular mechanism of circular RNAs remain poorly understood. Here we assessed the tumorigenesis properties of a circular RNA, circFAT1 in osteosarcoma. METHODS: The effects of circFAT1/miR-375/YAP1 was evaluated on human osteosarcoma cells growth, apoptosis, migration, invasion and tumorigenesis...
December 4, 2018: Molecular Cancer
Hongcai Cai, Yamin Li, Jean Damascene Niringiyumukiza, Ping Su, Wenpei Xiang
Circular RNA (circRNA) is a class of newly discovered noncoding RNA (ncRNA), presenting as a special covalent loop without a 5' cap or 3' tail. Multiple biological properties of circRNA have been revealed during the past decades, such as widespread expression, high conservation, cell-specificity, tissue-specificity and developmental stage-specific expression patterns, as well as resistance to RNase R digestion. CircRNA also exhibits diverse biological functions, including regulation of host genes, alternative splicing, miRNA sponges, protein traps and even protein synthesis...
December 1, 2018: Mechanisms of Ageing and Development
(no author information available yet)
[This corrects the article on p. 4871 in vol. 10, PMID: 30425578.].
2018: Cancer Management and Research
Handong Sun, Pengcheng Xi, Zhiqiang Sun, Qian Wang, Bin Zhu, Jian Zhou, Hui Jin, Wubin Zheng, Weiwei Tang, Hongyong Cao, Xiufeng Cao
Background: Circular RNAs(circRNAs) have been reported as a diverse class of endogenous RNA that regulate gene expression in eukaryotes. Recent evidence suggested that many circular RNAs can act as oncogenes or tumor suppressors through sponging microRNAs. However, the function of circular RNAs in gastric cancer remains largely unknown. Materials and methods: The circRNA levels in gastric carcinoma tissues and plasmas were detected by real-time quantitative reverse transcription-polymerase chain reaction...
2018: Cancer Management and Research
You Zhou, Xiao Zheng, Bin Xu, Lujun Chen, Qi Wang, Haifeng Deng, Jingting Jiang
Circular RNAs (circRNAs) were recently reported to be involved in the pathogenesis of Non-small cell lung cancer (NSCLC), however, the molecular mechanisms of circRNAs in cell proliferation, invasion and TKI drug resistance remain largely undetermined. Here, we identified hsa_circ_0004015 was upregulated in NSCLC tissues, and was associated with the poor overall survival rate of NSCLC patients. Knockdown of hsa_circ_0004015 significantly decreased cell viability, proliferation, and invasion, whereas overexpression exhibited opposed effects in vivo and in vitro...
November 30, 2018: Biochemical and Biophysical Research Communications
S T Wang, L B Liu, X M Li, Y F Wang, P J Xie, Q Li, R Wang, Q Wei, Y H Kang, R Meng, X H Feng
Recent studies indicate that circular RNA (circRNA) is involved in tumorigenesis, but its role in triple-negative breast cancer (TNBC) remains largely unknown. In this study, we characterized the role of circ-ITCH in TNBC and found that circ-ITCH was significantly down-regulated in TNBC tissues and cell lines and closely associated with poor prognosis. We therefore constructed the MDA-MB-231 and BT-549 TNBC cell lines stably expressing circ-ITCH by lentiviral vectors to determine its underlying mechanisms in TNBC progression...
September 29, 2018: Neoplasma
B J Chi, D M Zhao, L Liu, X Z Yin, F F Wang, S Bi, S L Gui, S B Zhou, W B Qin, D M Wu, S Q Wang
Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated with current therapies. Although the association between bladder cancer pathology and circRNAs remains undetermined, circRNAs signatures may be useful as prognostic and predictive factors and clinical tools for assessing disease state, treatment response and outcome. This study investigates if these circRNAs can be used as biomarkers for bladder cancer diagnosis and predicting treatment response...
September 16, 2018: Neoplasma
Yunlong He, E Mingyan, Chunbo Wang, Guohui Liu, Manru Shi, Shuang Liu
As a novel class of noncoding RNAs (ncRNAs), circular RNAs (circRNAs) have been verified to be potential biomarkers and therapeutic targets for human malignant tumors. However, the thorough understanding of circRNAs in the progression of esophageal squamous cell carcinoma (ESCC) still needs to be improved. This study focused on exploring the function and mechanism of circVRK1 in ESCC. At first, we examined the expression level of circVRK1 in ESCC tissues and cell lines with qRT-PCR. We found that circVRK1 was downregulated in ESCC tissues and cell lines...
November 30, 2018: International Journal of Biological Macromolecules
Bingxi Lei, Yutao Huang, Zhiwei Zhou, Yiying Zhao, Ashish Jung Thapa, Wenpeng Li, Wangqing Cai, Yuefei Deng
Glioma is one of the most common primary malignancies of the central nervous system, which has aggressive clinical behavior and a poorer prognosis. MicroRNAs (miRs) are a class of small noncoding RNAs that function as mediators of gene expression, which can be sponged by circRNA provided with a closed circular structure. Dysregulations of circular RNAs (circRNAs) and miRs have been implicated in the development and progression of glioma. In the current study, we investigated the role of circular RNA hsa_circ_0076248 in mediating the oncogenesis of glioma by sponging miR-181a to modulate silent information regulator 1 (SIRT1) expression in vitro and in vivo...
December 3, 2018: Journal of Cellular Biochemistry
Na Cheng, Juhua Xiao, Shanfei Ge, Juntao Li, Jiansheng Huang, Xiaoping Wu, Shouhua Zhang, Tianxin Xiang
BACKGROUND This study was designed to detect and analyze miR-146b-mediated circular RNA (circRNA) expression in hepatic stellate cells. MATERIAL AND METHODS The experiment was divided into a control group and a siRNA-miR-146b group. The interference efficiency of siRNA-miR-146b was confirmed by real-time quantitative reverse transcription PCR (qRT-PCR) and the cells were collected, and total RNA was collected for high flux sequencing. The miRNA-targeted carcass were predicted. Finally, the expression of 5 circRNAs was verified by qRT-PCR...
December 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Yi Xu, Yue Yao, Kaiming Leng, Daolin Ji, Lijun Qu, Yueping Liu, Yunfu Cui
BACKGROUND/AIMS: Circular RNAs (circRNAs) are a class of non-coding RNAs. They have been proved to be critically involved in tumorigenesis and progression of malignancies through competing endogenous RNA (ceRNA) mechanism. Nevertheless, the exploration between circRNAs and pathogenesis of breast cancer (BC) is limited. Previously, circ_0005230 was identified upregulated in BC tissues screened by circRNA microarray. In the present study, we aimed to investigate the expression pattern, functional role, and mechanism of circ_0005230 in BC...
November 30, 2018: Cellular Physiology and Biochemistry
Ruicheng Yang, Bojie Xu, Bo Yang, Jiyang Fu, Lu Liu, Nouman Amjad, Aoling Cai, Chen Tan, Huanchun Chen, Xiangru Wang
With their essential regulatory roles in gene expression and high abundance in the brain, circular RNAs (circRNAs) have recently attracted considerable attention. Many studies have shown that circRNAs play important roles in the pathology of CNS diseases, but whether circRNAs participate in E. coli-induced bacterial meningitis is unclear. We used high-throughput sequencing to analyze the transcriptional profiles of host circRNAs in primary brain microvascular endothelial cells in response to meningitic E...
October 26, 2018: Molecular Therapy. Nucleic Acids
Chaohui Gu, Naichun Zhou, Zhiyu Wang, Guanru Li, Yipping Kou, Shunli Yu, Yongjie Feng, Long Chen, Jinjian Yang, Fengyan Tian
Bladder cancer is a serious cancer in the world, especially in advanced countries. Bladder cancer stem cells (CSCs) drive bladder tumorigenesis and metastasis. Circular RNAs (circRNAs) are involved in many biological processes, but their roles in bladder oncogenesis and bladder CSCs are unclear. Here, we identified that circGprc5a is upregulated in bladder tumors and CSCs. circGpr5a knockdown impairs the self-renewal and metastasis of bladder CSCs, and its overexpression exerts an opposite role. circGpr5a has peptide-coding potential and functions through a peptide-dependent manner...
October 18, 2018: Molecular Therapy. Nucleic Acids
Zhijun Li, Bisheng Zhou, Pengyi Zhen, Huibing Li, Xiaohui Wang, Zhenguo Shi, Qingjiang Han
Increasing evidence showed that circular RNAs (circRNAs) play critical roles in tumorigenesis. However, the roles and underlying mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain unclear. In the present study, we identified a novel circRNA circPCNXL2, which was significantly upregulated in ccRCC by circular RNA microarray. Further analysis revealed that circPCNXL2 was significantly increased and correlated with poor overall survival of ccRCC patients. Function assays revealed that circPCNXL2 knockdown reduced RCC cells proliferation, invasion in vitro, and decreased tumor growth in vivo...
November 29, 2018: Cell Cycle
Yue Zhang, Hui Zhang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang, Youwen He, Hong Shang, Xiaoxu Han
BACKGROUND: The events in early HIV infection (EHI) are important determinants of disease severity and progression rate to AIDS, but the mechanisms of pathogenesis in EHI have not been fully understood. Circular RNAs (circRNAs) have been verified as "microRNA sponges" that regulate gene expression through competing endogenous RNA (ceRNA) networks, but circRNA expression profiles and their contribution to EHI pathogenesis are still unclear. METHODS: Two different libraries were constructed with RNA from human peripheral blood mononuclear cells from 3 HARRT-naive EHI patients and 3 healthy controls (HCs)...
November 29, 2018: Journal of Translational Medicine
Simranjeet Kaur, Aashiq H Mirza, Flemming Pociot
Understanding distinct cell-type specific gene expression in human pancreatic islets is important for developing islet regeneration strategies and therapies to improve β-cell function in type 1 diabetes (T1D). While numerous transcriptome-wide studies on human islet cell-types have focused on protein-coding genes, the non-coding repertoire, such as long non-coding RNA, including circular RNAs, remains mostly unexplored. Here, we explored transcriptional landscape of human α-, β-, and exocrine cells from published total RNA sequencing (RNA-seq) datasets to identify circular RNAs (circRNAs)...
November 27, 2018: Non-Coding RNA
Guo-Hua Gong, Feng-Mao An, Yu Wang, Ming Bian, Di Wang, Cheng-Xi Wei
BACKGROUND/AIMS: Temporal lobe epilepsy (TLE) is the most common form of adult localization-related epilepsy that is accompanied by progressive etiopathology and high incidences of drug resistance. Circular RNAs (circRNAs) play important roles in fine-tuning gene expression, however, the expression profile and clinical significance of circRNAs in TLE remains unknown. METHODS: Circular RNA microarray was conducted to identify TLE-related circRNAs. CCK8 assays and flow cytometric assays were conducted to clarify the role of circRNA in TLE in vitro...
November 28, 2018: Cellular Physiology and Biochemistry
Xunsha Sun, Yulin Jin, Qihua Liang, Jie Tang, Jinsong Chen, Qiuxia Yu, Fatao Li, Yan Li, Jieying Wu, Shaoqing Wu
BACKGROUND: Hypoxic preconditioning alters the biological properties of mesenchymal stem cells (MSCs). It is not known whether this process has an effect on circular RNAs (circRNAs) in MSCs. METHODS: Human placental chorionic plate-derived MSCs (hpcpMSCs) isolated from the same placentae were classed into two groups: hypoxic pretreated (hypoxia) group and normally cultured (normoxia) group. The comparative circRNA microarray analysis was used to determine circRNAs expression and verified by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) in the two groups...
November 28, 2018: Journal of Clinical Laboratory Analysis
Yangyang Zhang, Xianting Ke, Jingjing Liu, Xiue Ma, Yi Liu, Dandan Liang, Luxin Wang, Changfa Guo, Yiwei Luo
Circular RNAs (circRNAs) are non-coding RNAs forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In the present study, four left atrial appendages (LAA) of patients with NPAF and four normal LAAs were examined via RNA sequencing, and their potential functions were investigated via bioinformatics analysis...
November 26, 2018: Molecular Medicine Reports
Shao-Bo Ouyang, Jun Wang, Si-Yu Zhao, Xian-Hua Zhang, Lan Liao
Objectives: Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression profile of circRNAs in OSCC tumor tissues was performed by high-throughput sequencing...
November 2018: Iranian Journal of Basic Medical Sciences
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