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Generalized anxiety disorder

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https://www.readbyqxmd.com/read/27920976/resting-state-theta-band-connectivity-and-graph-analysis-in-generalized-social-anxiety-disorder
#1
Mengqi Xing, Reza Tadayonnejad, Annmarie MacNamara, Olusola Ajilore, Julia DiGangi, K Luan Phan, Alex Leow, Heide Klumpp
BACKGROUND: Functional magnetic resonance imaging (fMRI) resting-state studies show generalized social anxiety disorder (gSAD) is associated with disturbances in networks involved in emotion regulation, emotion processing, and perceptual functions, suggesting a network framework is integral to elucidating the pathophysiology of gSAD. However, fMRI does not measure the fast dynamic interconnections of functional networks. Therefore, we examined whole-brain functional connectomics with electroencephalogram (EEG) during resting-state...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27920738/an-investigation-of-diagnostic-accuracy-and-confidence-associated-with-diagnostic-checklists-as-well-as-gender-biases-in-relation-to-mental-disorders
#2
Jan C Cwik, Fabienne Papen, Jan-Erik Lemke, Jürgen Margraf
This study examines the utility of checklists in attaining more accurate diagnoses in the context of diagnostic decision-making for mental disorders. The study also aimed to replicate results from a meta-analysis indicating that there is no association between patients' gender and misdiagnoses. To this end, 475 psychotherapists were asked to judge three case vignettes describing patients with Major Depressive Disorder (MDD), Generalized Anxiety Disorder, and Borderline Personality Disorder. Therapists were randomly assigned to experimental conditions in a 2 (diagnostic method: with using diagnostic checklists vs...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27920735/lower-sensitivity-to-happy-and-angry-facial-emotions-in-young-adults-with-psychiatric-problems
#3
Charlotte Vrijen, Catharina A Hartman, Gerine M A Lodder, Maaike Verhagen, Peter de Jonge, Albertine J Oldehinkel
Many psychiatric problem domains have been associated with emotion-specific biases or general deficiencies in facial emotion identification. However, both within and between psychiatric problem domains, large variability exists in the types of emotion identification problems that were reported. Moreover, since the domain-specificity of the findings was often not addressed, it remains unclear whether patterns found for specific problem domains can be better explained by co-occurrence of other psychiatric problems or by more generic characteristics of psychopathology, for example, problem severity...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27919307/patterns-and-correlates-of-major-depression-in-chinese-adults-a-cross-sectional-study-of-0-5-million-men-and-women
#4
Y Chen, D Bennett, R Clarke, Y Guo, C Yu, Z Bian, L Ma, Y Huang, Q Sun, N Zhang, X Zheng, J Chen, R Peto, K S Kendler, L Li, Z Chen
BACKGROUND: Worldwide 350 million people suffer from major depression, with the majority of cases occurring in low- and middle-income countries. We examined the patterns, correlates and care-seeking behaviour of adults suffering from major depressive episode (MDE) in China. METHOD: A nationwide study recruited 512 891 adults aged 30-79 years from 10 provinces across China during 2004-2008. The 12-month prevalence of MDE was assessed by the Modified Composite International Diagnostic Interview-short form...
December 6, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27919020/psychosocial-factors-associated-with-migraine-and-tension-type-headache-in-medical-students
#5
Elena R Lebedeva, Natalia R Kobzeva, Denis V Gilev, Nadezhda V Kislyak, Jes Olesen
BACKGROUND: In our previous study of workers, blood donors and medical students, students stood out with a higher 1-year prevalence of migraine (28%) and tension-type headache (TTH) (74%). General factors associated with headache were common for all groups except low physical activity. The hypothesis of this study was therefore that a number of psychosocial factors relating to the personal sphere would better explain the high prevalence of migraine and TTH in students. METHODS: The study population consisted of 1042 students (719 females, 323 males, mean age 20...
November 8, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27918275/behavioral-mechanisms-of-context-fear-generalization-in-mice
#6
Kylie A Huckleberry, Laura B Ferguson, Michael R Drew
There is growing interest in generalization of learned contextual fear, driven in part by the hypothesis that mood and anxiety disorders stem from impaired hippocampal mechanisms of fear generalization and discrimination. However, there has been relatively little investigation of the behavioral and procedural mechanisms that might control generalization of contextual fear. We assessed the relative contribution of different contextual features to context fear generalization and characterized how two common conditioning protocols-foreground (uncued) and background (cued) contextual fear conditioning-affected context fear generalization...
December 2016: Learning & Memory
https://www.readbyqxmd.com/read/27917492/predictors-of-developing-mathematics-anxiety-among-middle-school-students-a-2-year-prospective-study
#7
Nir Madjar, Gil Zalsman, Abraham Weizman, Shaul Lev-Ran, Gal Shoval
While there is an abundance of research pertaining to the development of anxiety disorders, there is still a dearth of knowledge regarding the development of anxiety in the general population. The objective of this study was to longitudinally explore the development of mathematics anxiety among normative middle-school students, and to identify the moderating role of gender, school transition and scholastic achievements on these trajectories. Subjects included 413 sixth grade students (53.3% females, mean age 11...
December 4, 2016: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/27917455/what-s-the-worry-with-social-anxiety-comparing-cognitive-processes-in-children-with-generalized-anxiety-disorder-and-social-anxiety-disorder
#8
Cate S Hearn, Caroline L Donovan, Susan H Spence, Sonja March, Monique C Holmes
Social anxiety disorder (SAD) in children is often comorbid with generalized anxiety disorder (GAD). We investigated whether worry, intolerance of uncertainty, beliefs about worry, negative problem orientation and cognitive avoidance, that are typically associated with GAD, are present in children with SAD. Participants included 60 children (8-12 years), matched on age and gender. Groups included children: with primary GAD and without SAD (GAD); with primary SAD and without GAD (SAD); and without an anxiety disorder (NAD)...
December 5, 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/27917449/study-of-blood-exposure-related-mental-health-illness-among-clinical-nurses
#9
Xiaojia Xiong, Min Li, Yongliang Jiang, Xindeng Tong, Yanzhong Peng
Nurses are subjected to high amount of stress in the medical setting, and work-related stress often leads to mental problems. This study aims to investigate the mental health status of nurses exposed to blood through needlestick injuries. A total of 302 nurses working in the hospital of Guangdong, China, participated in this study. Out of the 302 nurses, 140 did not experience any needlestick injuries during the previous week, whereas 162 nurses experienced needlestick injuries. The General Health Questionnaire (GHQ)-28 Standardized Questionnaire, which uses physical, anxiety, social function, and depression subscales, was used in this study...
December 5, 2016: Frontiers of Medicine
https://www.readbyqxmd.com/read/27917000/emotional-working-memory-training-as-an-online-intervention-for-adolescent-anxiety-and-depression-a-randomised-controlled-trial
#10
E Leone de Voogd, Reinout W Wiers, Robert J Zwitser, Elske Salemink
OBJECTIVE: Anxiety and depression are highly prevalent disorders in adolescence. They are associated with deficits in working memory (WM), which also appears to increase rumination, worry, and negative mood. WM training, especially in an emotional context, might help in reducing or preventing these disorders. The current study investigated the direct effects of online emotional WM training on WM capacity, and short- and long-term effects on symptoms of anxiety and depression, and secondary measures of emotional functioning...
September 2016: Australian Journal of Psychology
https://www.readbyqxmd.com/read/27915159/public-speaking-avoidance-as-a-treatment-moderator-for-social-anxiety-disorder
#11
Bita Mesri, Andrea N Niles, Andre Pittig, Richard T LeBeau, Ethan Haik, Michelle G Craske
BACKGROUND AND OBJECTIVES: Cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT) have both garnered empirical support for the effective treatment of social anxiety disorder. However, not every patient benefits equally from either treatment. Identifying moderators of treatment outcome can help to better understand which treatment is best suited for a particular patient. METHODS: Forty-nine individuals who met criteria for social anxiety disorder were assessed as part of a randomized controlled trial comparing 12 weeks of CBT and ACT...
November 23, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#12
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
December 2, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27912875/long-term-chamomile-matricaria-chamomilla-l-treatment-for-generalized-anxiety-disorder-a-randomized-clinical-trial
#13
Jun J Mao, Sharon X Xie, John R Keefe, Irene Soeller, Qing S Li, Jay D Amsterdam
BACKGROUND: Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders treated in primary care, yet current therapies have limited efficacy and substantial side effects. PURPOSE: To evaluate long-term chamomile (Matricaria chamomilla L.) use for prevention of GAD symptom relapse. METHODS: Outpatients from primary care practices and local communities with a primary diagnosis of moderate-to-severe GAD were enrolled for this two-phase study at a large US academic medical center...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912871/short-term-open-label-chamomile-matricaria-chamomilla-l-therapy-of-moderate-to-severe-generalized-anxiety-disorder
#14
John R Keefe, Jun J Mao, Irene Soeller, Qing S Li, Jay D Amsterdam
BACKGROUND: Conventional drug treatments for Generalized Anxiety Disorder (GAD) are often accompanied by substantial side effects, dependence, and/or withdrawal syndrome. A prior controlled study of oral chamomile (Matricaria chamomilla L.) extract showed significant efficacy versus placebo, and suggested that chamomile may have anxiolytic activity for individuals with GAD. HYPOTHESIS: We hypothesized that treatment with chamomile extract would result in a significant reduction in GAD severity ratings, and would be associated with a favorable adverse event and tolerability profile...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27909449/association-between-dsm-iv-anxiety-disorders-and-suicidal-behaviors-in-a-community-sample-of-south-korean-adults
#15
Seong-Jin Cho, Jin Pyo Hong, Jun-Young Lee, Jeong Soo Im, Kyoung-Sae Na, Jee Eun Park, Maeng Je Cho
OBJECTIVE: There are conflicting reports about whether individual anxiety disorders are independently associated with suicidal ideation and suicide attempts. We examined whether anxiety disorders are related to suicidal ideation and suicide attempts in a community sample of South Korean adults. METHODS: In-person interviews based on the South Korean version of the Composite International Diagnostic Interview were conducted to diagnose mental disorders. Multivariate logistic regression analysis was performed to examine whether anxiety disorders were associated with suicidal ideation and suicide attempts...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27903255/epigenetic-evidence-for-involvement-of-the-oxytocin-receptor-gene-in-obsessive-compulsive-disorder
#16
Carolina Cappi, Juliana Belo Diniz, Guaraci L Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H Marques, Marcelo Q Hoexter, Carlos A Pereira, Euripedes Constantino Miguel, Helena Brentani
BACKGROUND: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors...
November 30, 2016: BMC Neuroscience
https://www.readbyqxmd.com/read/27900164/prevalence-of-depression-and-anxiety-in-top-level-male-and-female-football-players
#17
Astrid Junge, Nina Feddermann-Demont
BACKGROUND: Scientific studies on the prevalence of mental health problems in elite athletes are rare, and most have had considerable methodological limitations, such as low response rate and heterogeneous samples. AIMS: To evaluate the prevalence of depression and anxiety in top-level football players in comparison to the general population, and to analyse potential risk factors. METHODS: Players of all first league (FL) and of four U-21 football teams in Switzerland were asked to answer a questionnaire on player's characteristics, the Centre of Epidemiologic Studies Depression Scale (CES-D) and the Generalized Anxiety Disorder (GAD-7) scale...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27898206/doomed-for-disorder-high-incidence-of-mood-and-anxiety-disorders-in-offspring-of-depressed-and-anxious-patients-a-prospective-cohort-study
#18
Petra J Havinga, Lynn Boschloo, Annelene J P Bloemen, Maaike H Nauta, Sybolt O de Vries, Brenda W J H Penninx, Robert A Schoevers, Catharina A Hartman
OBJECTIVE: Early recognition of individuals at risk for depressive and anxiety disorders is key in influencing onset and course of these disorders. Parental history is a potent risk factor for the development of these disorders in offspring. However, knowledge about the magnitude of this risk is limited as large-scale longitudinal studies with a follow-up into adulthood are scarce. Those offspring at highest risk may possibly be identified by easy-to-determine parental psychiatric characteristics, family context, and offspring characteristics...
November 22, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27895432/prevalence-of-depression-and-anxiety-in-patients-with-chronic-digestive-system-diseases-a-multicenter-epidemiological-study
#19
An-Zhong Zhang, Qing-Cai Wang, Kun-Ming Huang, Jia-Guo Huang, Chang-Hong Zhou, Fu-Qiang Sun, Su-Wen Wang, Feng-Ting Wu
AIM: To investigate the prevalence of depression and anxiety in patients with chronic digestive system diseases. METHODS: A total of 1736 patients with chronic digestive system diseases were included in this cross-sectional study, including 871 outpatients and 865 in-patients. A self-designed General Information for Patients of the Department of Gastroenterology of General Hospitals questionnaire was used to collect each patient's general information, which included demographic data (including age, sex, marital status, and education) and disease characteristics (including major diseases, disease duration, principal symptoms, chronic pain, sleep disorder, and limited daily activities)...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27894209/the-prevalence-and-risk-indicators-of-symptoms-of-common-mental-disorders-among-current-and-former-dutch-elite-athletes
#20
Vincent Gouttebarge, Ruud Jonkers, Maarten Moen, Evert Verhagen, Paul Wylleman, Gino Kerkhoffs
The aim of the study was to determine the prevalence and comorbidity of symptoms of common mental disorders (distress, anxiety/depression, sleep disturbance, eating disorders, adverse alcohol use) among current and former Dutch elite athletes, and to explore the inference between potential risk indicators (severe injury, surgery, life events, sport career dissatisfaction, social support) and the outcomes measures under investigation. Cross-sectional analyses were conducted on baseline questionnaires from an ongoing prospective cohort study among 203 current and 282 former elite Dutch athletes (response rate: 28% among current athletes and 95% among former athletes)...
November 29, 2016: Journal of Sports Sciences
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