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Generalized anxiety disorder

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https://www.readbyqxmd.com/read/29217995/the-alteration-of-irisin-brain-derived-neurotrophic-factor-axis-parallels-severity-of-distress-disorder-in-bronchial-asthma-patients
#1
Magdolna E Szilasi, Krisztian Pak, Laszlo Kardos, Viktoria E Varga, Ildiko Seres, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Gabor Tajti, Csaba Papp, Rudolf Gesztelyi, Judit Zsuga
Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin-brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29215903/clinician-ratings-of-vulnerable-and-grandiose-narcissistic-features-implications-for-an-expanded-narcissistic-personality-disorder-diagnosis
#2
Kasey Stanton, Mark Zimmerman
Conceptualizations of narcissistic personality disorder (NPD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (American Psychiatric Association, 2013) have been criticized for focusing too exclusively on grandiose narcissistic traits (e.g., exploitativeness and entitlement) and failing to capture vulnerable narcissistic features (e.g., feelings of inadequacy). We extended prior grandiose and vulnerable narcissism research by examining the degree to which clinician ratings of traits related to grandiosity overlapped with traits related to vulnerability in a large sample of adult outpatients (N = 2,149)...
December 7, 2017: Personality Disorders
https://www.readbyqxmd.com/read/29215804/cognitive-function-and-neuropsychological-comorbidities-in-children-with-newly-diagnosed-idiopathic-epilepsy
#3
Seung Yun Lee, Jang Ho Park, Sin Jae Park, Yangho Kim, Kyung Yeon Lee
BACKGROUND: In this study, we aimed to identify cognitive function and neuropsychological comorbidities in children with newly diagnosed idiopathic epilepsy. METHODS: We retrospectively reviewed the records of 97 antiepileptic drug-naïve children (9.7 ± 2.9 years; 54 males and 43 females) with newly diagnosed idiopathic epilepsy, all of whom underwent a neuropsychological battery. The battery consisted of the Korean Wechsler Intelligence Scale, Attention Deficit Hyperactivity Disorder (ADHD) Rating Scale, ADHD Diagnostic System, Children's Depression Inventory, and State-Trait Anxiety Inventory for Children...
January 15, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29215750/questionnaire-based-problematic-relationship-to-eating-and-food-is-associated-with-25-year-body-mass-index-trajectories-during-midlife-the-coronary-artery-risk-development-in-young-adults-cardia-study
#4
Cynthia Yoon, David R Jacobs, Daniel A Duprez, Gareth Dutton, Cora E Lewis, Dianne Neumark-Sztainer, Lyn M Steffen, Delia S West, Susan M Mason
OBJECTIVE: Problematic eating behaviors and attitudes are of public health concern. Questionnaire-based assessment of these behaviors is important for large-scale research on eating behaviors. The questionnaire on eating and weight patterns-revised (QEWP-R) measures potential problematic behaviors and attitudes toward food (including anxieties, compensatory actions, overeating and loss of control, dieting, and shape concerns) that in aggregate may indicate diagnosable eating disorders...
December 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29214849/the-dimensions-of-ruminative-thinking-one-for-all-or-all-for-one
#5
Ljiljana Mihić, Zdenka Novović, Milica Lazić, David J A Dozois, Radomir Belopavlović
The Ruminative Thought Scale (RTS) was developed to measure the ruminative thinking style, presumably common to various psychopathological disorders. However, prior factor-analytic research was inconclusive regarding unidimensionality versus multidimensionality of the RTS. The present study was conducted on a large, heterogeneous Serbian sample ( N = 838). A subsample was retested 6 months later providing information about symptoms of depression and various anxiety symptoms. Results showed that a bifactor model of the RTS (representing one general and four group factors) had a better fit than the second-order and one-factor models...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/29214394/serious-adverse-events-associated-with-anti-tumor-necrosis-factor-alpha-agents-in-pediatric-onset-inflammatory-bowel-disease-and-juvenile-idiopathic-arthritis-in-a-real-life-setting
#6
Serena Pastore, Samuele Naviglio, Arianna Canuto, Loredana Lepore, Stefano Martelossi, Alessandro Ventura, Andrea Taddio
OBJECTIVES: Anti-tumor necrosis factor alpha (anti-TNF-α) agents are generally well tolerated, yet they can be associated with serious adverse events (SAEs) in a minority of patients. We examined the incidence of SAEs in a pediatric referral center for chronic rheumatologic and gastroenterological inflammatory disorders. METHODS: Retrospective analysis of SAEs occurring during treatment with anti-TNF-α agents in patients with juvenile idiopathic arthritis (JIA) (n = 78)  or pediatric-onset inflammatory bowel disease (IBD) (n = 105) seen at the Institute for Maternal and Child Health IRCCS "Burlo Garofolo" in Trieste, Italy, between June 2001 and February 2016...
December 6, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29214085/sox5-null-heterozygous-mutation-in-a-family-with-adult-onset-hyperkinesia-and-behavioral-abnormalities
#7
Michael Zech, Katharina Poustka, Sylvia Boesch, Riccardo Berutti, Tim M Strom, Wolfgang Grisold, Werner Poewe, Juliane Winkelmann
SOX5 encodes a conserved transcription factor implicated in cell-fate decisions of the neural lineage. SOX5 haploinsufficiency induced by larger genomic deletions has been linked to a recognizable pediatric syndrome combining developmental delay with intellectual disability, mild dysmorphism, inadequate behavior, and variable additional features including motor disturbances. In contrast to SOX5-involving deletions, examples of pathogenic SOX5 small coding variations are sparse in the literature and have been described only in singular cases with phenotypic abnormalities akin to those seen in the SOX5 microdeletion syndrome...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/29213344/psychotherapy-for-major-depressive-disorder-and-generalized-anxiety-disorder-a-health-technology-assessment
#8
(no author information available yet)
Background: Major depressive disorder and generalized anxiety disorder are among the most commonly diagnosed mental illnesses in Canada; both are associated with a high societal and economic burden. Treatment for major depressive disorder and generalized anxiety disorder consists of pharmacological and psychological interventions. Three commonly used psychological interventions are cognitive behavioural therapy (CBT), interpersonal therapy, and supportive therapy. The objectives of this report were to assess the effectiveness and safety of these types of therapy for the treatment of adults with major depressive disorder and/or generalized anxiety disorder, to assess the cost-effectiveness of structured psychotherapy (CBT or interpersonal therapy), to calculate the budget impact of publicly funding structured psychotherapy, and to gain a greater understanding of the experiences of people with major depressive disorder and/or generalized anxiety disorder...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/29213232/stress-induced-chronic-visceral-pain-of-gastrointestinal-origin
#9
REVIEW
Beverley Greenwood-Van Meerveld, Anthony C Johnson
Visceral pain is generally poorly localized and characterized by hypersensitivity to a stimulus such as organ distension. In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and depression. The mechanisms linking visceral pain with these overlapping comorbidities remain to be elucidated. Evidence suggests that long term stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic visceral pain disorders such as irritable bowel syndrome (IBS)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29212828/detecting-anxiety-in-individuals-with-parkinson-disease-a-systematic-review
#10
Bria Mele, Jayna Holroyd-Leduc, Eric E Smith, Tamara Pringsheim, Zahinoor Ismail, Zahra Goodarzi
OBJECTIVE: To examine diagnostic accuracy of anxiety detection tools compared with a gold standard in outpatient settings among adults with Parkinson disease (PD). METHODS: A systematic review was conducted. MEDLINE, EMABASE, PsycINFO, and Cochrane Database of Systematic Reviews were searched to April 7, 2017. Prevalence of anxiety and diagnostic accuracy measures including sensitivity, specificity, and likelihood ratios were gathered. Pooled prevalence of anxiety was calculated using Mantel-Haenszel-weighted DerSimonian and Laird models...
December 6, 2017: Neurology
https://www.readbyqxmd.com/read/29212134/association-between-attention-bias-to-threat-and-anxiety-symptoms-in-children-and-adolescents
#11
Rany Abend, Leone de Voogd, Elske Salemink, Reinout W Wiers, Koraly Pérez-Edgar, Amanda Fitzgerald, Lauren K White, Giovanni A Salum, Jie He, Wendy K Silverman, Jeremy W Pettit, Daniel S Pine, Yair Bar-Haim
BACKGROUND: Considerable research links threat-related attention biases to anxiety symptoms in adults, whereas extant findings on threat biases in youth are limited and mixed. Inconsistent findings may arise due to substantial methodological variability and limited sample sizes, emphasizing the need for systematic research on large samples. The aim of this report is to examine the association between threat bias and pediatric anxiety symptoms using standardized measures in a large, international, multi-site youth sample...
December 6, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29211192/tobacco-addiction-in-the-psychiatric-population-and-in-the-general-population
#12
Renata Marques de Oliveira, Jair Lício Ferreira Santos, Antonia Regina Ferreira Furegato
OBJECTIVE: To estimate the degree of tobacco addiction and identify independently associated factors by comparing the psychiatric population of secondary and tertiary care with the general population of the primary healthcare network. METHOD: This is a cross-sectional epidemiological study, conducted in a municipality of São Paulo, with 134 smokers of a Mental Health Outpatient Unit (MHOU), a Psychiatric Hospital (PH), and a Primary Healthcare Unit (PHU). Data were collected by means of individual interviews, recorded on a mobile device...
December 4, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29210194/error-related-brain-activity-and-anxiety-symptoms-in-youth-with-autism-spectrum-disorder
#13
Tamara E Rosen, Matthew D Lerner
Individuals with autism spectrum disorder (ASD) often experience symptoms associated with generalized anxiety disorder, obsessive-compulsive disorder, and social anxiety disorder. In other populations, these same symptoms are associated with a larger error-related negativity (ERN), an event-related potential that reflects endogenous threat sensitivity. As such, it is possible that the ERN may relate to the clinical presentation of anxiety in ASD. However, studies examining these associations in youth with ASD have yielded mixed results...
December 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29210054/a-comparison-of-dsm-5-and-icd-11-ptsd-prevalence-comorbidity-and-disability-an-analysis-of-the-ukrainian-internally-displaced-person-s-mental-health-survey
#14
M Shevlin, P Hyland, F Vallières, J Bisson, N Makhashvili, J Javakhishvili, M Shpiker, B Roberts
OBJECTIVE: Recently, the American Psychiatric Association (DSM-5) and the World Health Organization (ICD-11) have both revised their formulation of post-traumatic stress disorder (PTSD). The primary aim of this study was to compare DSM-5 and ICD-11 PTSD prevalence and comorbidity rates, as well as the level of disability associated with each diagnosis. METHOD: This study was based on a representative sample of adult Ukrainian internally displaced persons (IDPs: N = 2203)...
December 5, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29208913/prevention-and-treatment-strategies-for-contextual-overgeneralization
#15
Dieuwke Sevenster, Kim Haesen, Bram Vervliet, Merel Kindt, Rudi D'Hooge
At the core of anxiety disorders lies the tendency to generalize fear from a threatening to a safe situation. A deeper understanding of the mechanisms that facilitate and restrain generalization in humans is therefore needed. Rodent studies showed that pre-exposure to a context that is similar to the threatening context enhanced generalization to the similar context. In Experiment 1 we replicated these animal findings in humans (US-expectancy). Studies on the underlying mechanisms showed that the pre-exposure representation was recalled during conditioning (due to similarity between the contexts) and the shock also became linked to the recalled representation, resulting in greater generalization...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29204388/clinic-based-group-multi-professional-education-causes-significant-decline-in-psoriasis-severity-a-randomized-open-label-pilot-study
#16
Shubh Mohan Singh, Tarun Narang, Keshavamurthy Vinay, Aditi Sharma, Ashirbad Satapathy, Sanjeev Handa, Sunil Dogra
Background: The evidence for efficacy of psychoeducational interventions in psoriasis is not well researched. Objective: The objective of this study was to assess the benefits of a group, multi-professional, psychoeducational training in psoriasis. Materials and Methods: Adults with moderate-to-severe psoriasis were randomized into psychoeducational intervention plus treatment (intervention arm [IA]) and treatment as usual alone (control arm [CA]) groups using random number tables...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29200525/mental-health-care-during-the-ebola-virus-disease-outbreak-in-sierra-leone
#17
Stania Kamara, Anna Walder, Jennifer Duncan, Antoinet Kabbedijk, Peter Hughes, Andrew Muana
Problem: Reported levels of mental health and psychosocial problems rose during the 2014-2015 Ebola virus disease outbreak in Sierra Leone. Approach: As part of the emergency response, existing plans to create mental health units within the existing hospital framework were brought forward. A nurse-led mental health and psychosocial support service, with an inpatient liaison service and an outpatient clinic, was set up at the largest government hospital in the country...
December 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29200376/anesthetic-considerations-for-patients-on-antidepressant-therapy-part-i
#18
Mana Saraghi, Leonard R Golden, Elliot V Hersh
Millions of patients take antidepressant medications in the United States for the treatment of depression or anxiety disorders. Some antidepressants are prescribed off-label to treat problems such as chronic pain, low energy, and menstrual symptoms. Antidepressants are a broad and expansive group of medications, but the more common drug classes include tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and monoamine oxidase inhibitors. A miscellaneous or "atypical" category covers other agents...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/29198292/polysomnography-detected-bruxism-in-children-is-associated-with-somatic-complaints-but-not-anxiety
#19
Candice A Alfano, Joanne L Bower, Jessica M Meers
STUDY OBJECTIVES: Sleep bruxism (SB) is common in children and is associated with somatic symptoms and sleep disturbance. Etiological theories posit the role of anxiety, suggesting youth with anxiety disorders may be at high risk for SB, but empirical data are lacking. Furthermore, parent report rather than polysomnography (PSG) has been used to examine SB-anxiety relationships in children. We examined rates of PSG-detected compared to parent-reported SB in children with generalized anxiety disorder (GAD) and healthy controls...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29198246/neurocognitive-dysfunctioning-and-the-impact-of-comorbid-depression-and-anxiety-in-patients-with-somatic-symptom-and-related-disorders-a-cross-sectional-clinical-study
#20
Lars de Vroege, Anique Timmermans, Willem J Kop, Christina M van der Feltz-Cornelis
BACKGROUND: The prevalence and severity of neurocognitive dysfunctioning of patients with somatic symptom and related disorders (SSRD) is unknown. Furthermore, the influence of comorbid depression and anxiety has not been evaluated. This study examines neurocognitive dysfunctioning of patients with SSRD and explores if comorbid depression and anxiety is associated with specific neurocognitive dysfunctioning. METHODS: Cross-sectional study with consecutive patients suffering from SSRD visiting an outpatient specialty mental health care Centre of Excellence for SSRD...
December 4, 2017: Psychological Medicine
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