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Frailty and sedentary

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https://www.readbyqxmd.com/read/30014320/sarcopenic-obesity
#1
REVIEW
Stergios A Polyzos, Andrew N Margioris
Sarcopenic obesity, a chronic condition, is today a major public health problem with increasing prevalence worldwide, which is due to progressively aging populations, the increasing prevalence of obesity, and the changes in lifestyle during the last several decades. Patients usually present to healthcare facilities for obesity and related comorbidities (type 2 diabetes mellitus, non-alcoholic fatty liver disease, dyslipidemia, hypertension, and cardiovascular disease) or for non-specific symptoms related to sarcopenia per se (e...
July 16, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29949848/time-spent-in-sedentary-behaviour-as-discriminant-criterion-for-frailty-in-older-adults
#2
Venicius Dantas da Silva, Sheilla Tribess, Joilson Meneguci, Jeffer Eidi Sasaki, Douglas de Assis Teles Santos, José Ailton Oliveira Carneiro, Jair Sindra Virtuoso Júnior
This paper aims to analyse whether time spent in sedentary behaviour was a discriminant criterion for frailty in older adults. This was a cross-sectional study conducted in a sample of 457 elderly individuals aged ≥60 years. Frailty was defined as the presence of three or more of the following criteria: Unintentional weight loss, low walking speed at a 4.57 m course, reduced manual grip strength, exhaustion and insufficient physical activity level. Participants were classified into two groups: Non-frail or frail...
June 26, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29898680/association-between-health-risks-and-frailty-in-relation-to-the-degree-of-housing-damage-among-elderly-survivors-of-the-great-east-japan-earthquake
#3
M Tsubota-Utsugi, Y Yonekura, K Tanno, M Nozue, H Shimoda, N Nishi, K Sakata, S Kobayashi
BACKGROUND: Many survivors of the Great East Japan Earthquake that occurred in 2011 were at risk of deteriorating health, especially elderly people living in disaster-stricken areas. The objectives of this prospective study were: a) to clarify the different lifestyle and psychosocial factors associated with frailty by sex among the non-disabled elderly survivors, and b) to describe the differences in characteristics stratified by the degree of disaster-related housing damage. METHODS: We followed 2261 Japanese survivors aged ≥65 years (45...
June 4, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29750055/noncommunicable-disease-and-multimorbidity-in-young-adults-with-cerebral-palsy
#4
Daniel G Whitney, Edward A Hurvitz, Jennifer M Ryan, Maureen J Devlin, Michelle S Caird, Zachary P French, Elie C Ellenberg, Mark D Peterson
Purpose: Individuals with cerebral palsy (CP) are at increased risk for frailty and chronic disease due to factors experienced throughout the lifespan, such as excessive sedentary behaviors and malnutrition. However, little is known about noncommunicable diseases (NCDs) and multimorbidity profiles in young adults with CP. The study objective was to compare NCD and multimorbidity profiles between young adults with and without CP. Methods: A clinic-based sample of adults (18-30 years) with (n=452) and without (n=448) CP was examined at the University of Michigan Medical Center...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29733701/the-impact-of-sedentary-and-physical-activity-behaviour-on-frailty-in-middle-aged-and-older-adults
#5
Dustin Scott Kehler
Physical activity and sedentary behaviours are associated with frailty. However, it is unknown if different accumulation patterns of these behaviours are linked with frailty. Four studies were conducted: the first 3 determined if bouts of moderate-vigorous physical activity (MVPA) and patterns of sedentary behaviours were associated with frailty (study 1), and if sex (study 2) and cardiovascular disease (CVD) status (study 3) affected these associations. Study 4 systematically reviewed the evidence to determine if preoperative physical activity and sedentary behaviours were linked to postcardiac surgical outcomes...
June 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29701640/wearable-sensors-and-the-assessment-of-frailty-among-vulnerable-older-adults-an-observational-cohort-study
#6
Javad Razjouyan, Aanand D Naik, Molly J Horstman, Mark E Kunik, Mona Amirmazaheri, He Zhou, Amir Sharafkhaneh, Bijan Najafi
Background: The geriatric syndrome of frailty is one of the greatest challenges facing the U.S. aging population. Frailty in older adults is associated with higher adverse outcomes, such as mortality and hospitalization. Identifying precise early indicators of pre-frailty and measures of specific frailty components are of key importance to enable targeted interventions and remediation. We hypothesize that sensor-derived parameters, measured by a pendant accelerometer device in the home setting, are sensitive to identifying pre-frailty...
April 26, 2018: Sensors
https://www.readbyqxmd.com/read/29567100/force-velocity-profiling-in-older-adults-an-adequate-tool-for-the-management-of-functional-trajectories-with-aging
#7
Julian Alcazar, Carlos Rodriguez-Lopez, Ignacio Ara, Ana Alfaro-Acha, Irene Rodríguez-Gómez, Roberto Navarro-Cruz, Jose Losa-Reyna, Francisco J García-García, Luis M Alegre
INTRODUCTION: The actual mechanisms leading to a reduced muscle power and functional ability in older adults are poorly understood. We investigated the association between different force-velocity (F-V) profiles and impaired muscle power, physical and cognitive function, frailty, and health-related quality of life (HRQoL) in older people. METHODS: Physical function (habitual gait speed, timed up-and-go test, sit-to-stand and stair-climbing ability), cognitive function, HRQoL and frailty were evaluated in 31 older subjects (70-85 years)...
July 15, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29507821/gender-associated-factors-for-frailty-and-their-impact-on-hospitalization-and-mortality-among-community-dwelling-older-adults-a-cross-sectional-population-based-study
#8
Qin Zhang, Huanyu Guo, Haifeng Gu, Xiaohong Zhao
Background: Frailty associated with aging increases the risk of falls, disability, and death. We investigated gender-associated factors for frailty. Methods: Data of 3,079 geriatric subjects were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 database. After excluding 1,126 subjects with missing data on frailty, medical history and survival, data of 1,953 patients were analyzed. Main endpoints were frailty prevalence, mortality rates and causes of death...
2018: PeerJ
https://www.readbyqxmd.com/read/29421349/the-association-between-bouts-of-moderate-to-vigorous-physical-activity-and-patterns-of-sedentary-behavior-with-frailty
#9
D Scott Kehler, Ian Clara, Brett Hiebert, Andrew N Stammers, Jacqueline L Hay, Annette Schultz, Rakesh C Arora, Navdeep Tangri, Todd A Duhamel
OBJECTIVES: To determine if bouts of moderate-vigorous physical activity (MVPA) and patterns of sedentary behavior are associated with frailty. METHOD: Accelerometry from community-dwelling adults ≥50 years old (n = 2317) enrolled in the 2003-04 and 2005-06 National Health and Nutrition Examination Survey were used. Bouted (≥10 min) and sporadic (<10 min) durations of MVPA were analyzed based on meeting 0%, 1-49%, 50-99%, and ≥100% of physical activity guidelines (150 min/week of MVPA)...
April 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29321814/the-epigenetic-clock-and-objectively-measured-sedentary-and-walking-behavior-in-older-adults-the-lothian-birth-cohort-1936
#10
Catharine R Gale, Riccardo E Marioni, Iva Čukić, Sebastien F Chastin, Philippa M Dall, Manon L Dontje, Dawn A Skelton, Ian J Deary
Background: Estimates of biological age derived from DNA-methylation patterns-known as the epigenetic clock-are associated with mortality, physical and cognitive function, and frailty, but little is known about their relationship with sedentary behavior or physical activity. We investigated the cross-sectional relationship between two such estimates of biological age and objectively measured sedentary and walking behavior in older people. Methods: Participants were 248 members of the Lothian Birth Cohort 1936...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29281995/prevalence-and-correlates-of-frailty-in-an-older-rural-african-population-findings-from-the-haalsi-cohort-study
#11
Collin F Payne, Alisha Wade, Chodziwadziwa W Kabudula, Justine I Davies, Angela Y Chang, F Xavier Gomez-Olive, Kathleen Kahn, Lisa F Berkman, Stephen M Tollman, Joshua A Salomon, Miles D Witham
BACKGROUND: Frailty is a key predictor of death and dependency, yet little is known about frailty in sub-Saharan Africa despite rapid population ageing. We describe the prevalence and correlates of phenotypic frailty using data from the Health and Aging in Africa: Longitudinal Studies of an INDEPTH Community cohort. METHODS: We analysed data from rural South Africans aged 40 and over. We used low grip strength, slow gait speed, low body mass index, and combinations of self-reported exhaustion, decline in health, low physical activity and high self-reported sedentariness to derive nine variants of a phenotypic frailty score...
December 28, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29053774/plasma-klotho-and-frailty-in-older-adults-findings-from-the-inchianti-study
#12
Michelle Shardell, Richard D Semba, Rita R Kalyani, Stefania Bandinelli, Aric A Prather, Chee W Chia, Luigi Ferrucci
Background: The hormone klotho, encoded by the gene klotho, is primarily expressed in the kidney and choroid plexus of the brain. Higher klotho concentrations have been linked to better physical performance; however, it is unknown whether klotho relates to frailty status in older adults. Methods: Plasma klotho was measured in 774 participants aged ≥ 65 years enrolled in InCHIANTI, a prospective cohort study comprising Italian adults. Frailty status was assessed at three and six years after enrollment...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28892505/frailty-is-associated-with-objectively-assessed-sedentary-behaviour-patterns-in-older-adults-evidence-from-the-toledo-study-for-healthy-aging-tsha
#13
Borja Del Pozo-Cruz, Asier Mañas, María Martín-García, Jorge Marín-Puyalto, Francisco J García-García, Leocadio Rodriguez-Mañas, Amelia Guadalupe-Grau, Ignacio Ara
OBJECTIVE: The aim of this study was to examine the association of sedentary behaviour patterns with frailty in older people. SETTING: Clinical setting. DESIGN: Cross-sectional, observational study. PARTICIPANTS AND MEASUREMENTS: A triaxial accelerometer was used in a subsample from the Toledo Study for Healthy Aging (519 participants, 67-97 years) to assess several sedentary behaviour patterns including sedentary time per day, the number and duration (min) of breaks in sedentary time per day, and the proportion of the day spent in sedentary bouts of 10 minutes or more...
2017: PloS One
https://www.readbyqxmd.com/read/28860729/aging-and-extrapulmonary-effects-of-chronic-obstructive-pulmonary-disease
#14
Emanuela Tudorache, Ariadna Petronela Fildan, Mirela Frandes, Elena Dantes, Doina Ecaterina Tofolean
INTRODUCTION: People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. Of particular concern is the decline in cognitive and functional performance. Decrease in cognitive and functional performance will finally lead to decreased health status, sedentary life style and premature frailty. AIM: The aim of this study is to compare functional performance and cognitive status in patients with COPD of different ages and to examine the changes in extrapulmonary effects...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28827436/association-between-sedentary-time-and-mortality-across-levels-of-frailty
#15
Olga Theou, Joanna M Blodgett, Judith Godin, Kenneth Rockwood
BACKGROUND: Sedentary behaviours are associated with adverse health outcomes in middle-aged and older adults, even among those who exercise. We examined whether the degree of frailty affects the association between sedentary behaviours and higher risk of mortality. METHODS: In this prospective cohort study, we used data from 3141 community-dwelling adults 50 years of age or older from the 2003/04 and 2005/06 cohorts of the US National Health and Nutrition Examination Survey...
August 21, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28824439/time-spent-sitting-is-associated-with-changes-in-biomarkers-of-frailty-in-hospitalized-older-adults-a-cross-sectional-study
#16
Jair S Virtuoso Júnior, Liliane B Roza, Sheilla Tribess, Joilson Meneguci, Edmar L Mendes, Maycon S Pegorari, Flávia A Dias, Darlene M Dos Santos Tavares, Jeffer E Sasaki
Background: Sedentary behavior has gained prominence in the literature as a risk factor for health and mortality independent of physical activity level; however, little is known about the relationship of sedentary behavior with frailty in older adults. The aim of this study was to investigate if time spent sitting can be used as a discriminator of frailty in older hospitalized persons. Methods: The study included 162 hospitalized inpatients aged ≥60 years. Blood samples were taken for analyzing leukocyte counts and serum concentrations of C-reactive protein (CRP)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28701523/lifelong-exercise-but-not-short-term-high-intensity-interval-training-increases-gdf11-a-marker-of-successful-aging-a-preliminary-investigation
#17
Bradley T Elliott, Peter Herbert, Nicholas Sculthorpe, Fergal M Grace, Daniel Stratton, Lawrence D Hayes
Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males. Therefore, we investigated whether serum total myostatin, free myostatin, follistatin, and growth and differentiation factor 11 (GDF11) were altered following high-intensity interval training (HIIT) in a group of 13 lifelong sedentary (SED; 64 [6] years) and 11 lifelong exercising (LEX; 62 [6] years) older males...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28653132/food-insecurity-and-aging-outcomes-in-older-adults-living-with-hiv
#18
Nancy A Hessol, Roland Zepf, Elizabeth Zobell, Sheri D Weiser, Malcolm D John
Little is known about food insecurity and its association with geriatric outcomes in older people living with HIV (PLWH). This was a cross-sectional study of 230 HIV-infected patients aged 50 and older recruited in December 2012 through June 2016. Poisson logistic regression models estimated the prevalence ratio (PR) and 95% confidence intervals (CI) for the association between food insecurity and the following geriatric outcomes: frailty, physical health and function, social support, mental health and cognition, and behavioral health...
December 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28649108/-aging-and-homeostasis-prevention-and-treatment-of-sarcopenia-and-frailty
#19
Hidenori Arai
Frailty and sarcopenia are geriatrics syndromes that are increasing in the super aged society and are an important risk factor for the outcomes such as disability, falls, falls/fractures, and death. Although aging is a major factor in both syndromes, muscle weakness is accelerated by malnutrition such as protein and vitamin D deficiency and lack of exercise in a sedentary lifestyle. Therefore, nutritional guidance and exercise instruction are extremely important as well as management of diseases in older people...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28633487/high-intensity-interval-training-improves-physical-performance-and-frailty-in-aged-mice
#20
Kenneth Ladd Seldeen, Ginger Lasky, Merced Marie Leiker, Manhui Pang, Kirkwood Ely Personius, Bruce Robert Troen
Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both strength and endurance benefits with lower time commitments than other exercise regimens. To better understand the impacts of HIIT during aging, we compared 24-month-old C57BL/6J sedentary mice with those that were administered 10-minute uphill treadmill HIIT sessions three times per week over 16 weeks...
March 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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