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Vitamin D Cancer

Sara Tagliaferri, Debora Porri, Rachele De Giuseppe, Matteo Manuelli, Francesco Alessio, Hellas Cena
Increased oxidative stress has been implicated as a potential causal factor in the development of several diseases. In the last decade, an extensive literature has been produced on vitamin D, not limited to its well-known function like a steroid hormone on skeletal tissue, but for its potential pleiotropic role in human health. Several researchers have suggested relationships between vitamin D intake and health outcomes such as cancer prevention and increased immunity, or possible role in preventing diabetes, and in inflammation...
October 17, 2018: Nutrition Research Reviews
Yosuke Mukai, Hidetoshi Eguchi
No abstract text is available yet for this article.
October 15, 2018: Annals of Surgical Oncology
Tanja M Šarenac, Momir Mikov
Bile acids (BAs) are amphiphilic molecules with 24 carbon atoms and consist of a hydrophobic and a rigid steroid nucleus, to which are attached a hydrophilic hydroxyl group and a flexible acidic aliphatic side chain. The steroidal core of BAs constitutes a saturated cyclopentanoperhydrophenanthrene skeleton, consisting of three six-membered (A, B, and C) and one five-membered ring (D). Primary BAs are produced in the hepatocytes, while secondary BAs are formed by modifying the primary BAs in the intestinal lumen, i...
2018: Frontiers in Pharmacology
Barbara J Boucher
Vitamin D deficiency is common, world-wide, but vitamin D repletion throughout life, and into older age, has accepted health benefits for bone. Many mechanisms through which vitamin D also benefits soft tissues are understood, and clinical evidence of such benefits is now accumulating, especially following re-analyses of trial data, which are revealing previously missed health benefits with correction of deficiency. Areas covered: The sources of vitamin D, its activation, mechanistic effects; problems of trials of supplementation for reducing health risks, the benefits shown for mortality, cardiovascular disease, infection and cancer; the global problem of vitamin D deficiency; age-related reductions in vitamin D efficacy, and currently recommended intakes...
October 5, 2018: Expert Review of Endocrinology & Metabolism
Xia Jiang, Douglas P Kiel, Peter Kraft
Vitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, cardiovascular conditions and more. However, the causal role of vitamin D beyond its importance for bone health remains unclear and is under much debate. Twin and familial studies from past decades have demonstrated a nontrivial heritability of circulating vitamin D concentrations...
October 11, 2018: Bone
Wei Zheng, Bofeng Duan, Qian Zhang, Linna Ouyang, Wei Peng, Fuyong Qian, Yibin Wang, Shiting Huang
OBJECTIVE: Cancer stem cells (CSCs) are responsible for the drug resistance of breast cancers. Vitamin D deficiency promotes tumor resistance. This study examined the effect of vitamin D and vitamin D receptor (VDR) expression on the tamoxifen resistance of CSCs. METHODS: MCF-7 cells were treated with 1,25(OH)2 D3 and their levels of VDR expression, viability, and apoptosis were detected. CD133+ MCF-7 stem cells were identified and transfected with a VDR-overexpression plasmid...
October 12, 2018: Bioscience Reports
Olfat G Shaker, Mahmoud A Senousy
BACKGROUND: Genetic susceptibility for breast cancer (BC) is still poorly understood. A combination of multiple low-penetrant alleles of cancer-related genes and gene-gene interactions (epistasis) contributes to BC risk. Genetic variants in receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), chitinase-3-like protein 1 (CHI3L1), and vitamin D receptor (VDR) genes are implicated in breast carcinogenesis; however, the influence of their epistatic effects on BC susceptibility has not yet been studied...
September 19, 2018: Clinical Breast Cancer
Gokhan Yaprak, Cengiz Gemici, Sule Temizkan, Sevim Ozdemir, Berfu Cinkit Dogan, Ozgur Ozan Seseogullari
BACKGROUND: Decrease in bone mineral density, osteoporosis development, bone toxicity and resulting insufficiency fractures as late effect of radiotherapy are not well known. Osteoporosis development related to radiotherapy has not been investigated properly and insufficiency fractures are rarely reported for vertebral bones. METHODS: Ninety-seven patients with gastric adenocarcinoma were evaluated for adjuvant treatment after surgery. While 73 out of 97 patients treated with adjuvant chemoradiotherapy comprised the study group, 24 out of 97 patients with early stage disease without need of adjuvant treatment comprised the control group...
October 11, 2018: BMC Cancer
Elizabeth Kagotho, Geoffrey Omuse, Nancy Okinda, Peter Ojwang
BACKGROUND: Vitamin D has been known since the twentieth Century for its benefits in bone health. Recent observational studies have demonstrated its benefits in infectious diseases such as tuberculosis and non-communicable diseases such as diabetes mellitus, cardiovascular diseases and cancer. This has led to a dramatic increase in testing among adults. The cut-offs for vitamin D deficiency have been debated for decades and the current cut off is derived from a Caucasian population. Studies done among black African adults in Africa are few with vitamin D deficiency ranging from 5 to 91%...
October 11, 2018: BMC Endocrine Disorders
Arunkumar Karthikayan, Sathasivam Sureshkumar, Dharanipragada Kadambari, Chellappa Vijayakumar
OBJECTIVE: This study was conducted to assess the serum 25-hydroxy (OH) vitamin D levels in patients with breast cancer compared to healthy controls and to identify its association with aggressive breast cancer phenotypes. MATERIALS AND METHODS: Serum 25-OH vitamin D levels of 78 breast cancer patients and 78 matched healthy controls were estimated using ELISA. The cases and controls were matched with respect to age, menopausal status, parity, weight, height and co-morbidities...
August 2018: Archives of Endocrinology and Metabolism
Nadir Koçak, Süleyman Nergiz, İbrahim Halil Yıldırım, Yağmur Duran
Cancer is standing like a bottomless pit or a black hole in front of mankind. Scientists are trying all possible ways to find a solution against to cancer. As known, cancer is a phenomenon fed from internal dynamics. One of internal dynamic is cancer stem cells that are involved in the formation and development of cancer. Because of these dynamics, scientists began to search solution inside of the body. Another internal dynamic is vitamin D and it is not only important in calcium homeostasis but also it is important for cell proliferation, differentiation, and apoptosis...
September 30, 2018: Cellular and Molecular Biology
Catherine Cormier
A genetic disorder should be suspected in patients with hypercalcemia, notably those who are young; have family members with hypercalcemia; or have had a tumor of the endocrine pancreas, thyroid, pituitary, adrenal gland, or jaw bone. All forms of hypercalcemia should be interpreted according to the serum level of parathyroid hormone (PTH). Genetic forms are thus classified as related or unrelated to a parathyroid gland disorder. When the PTH level is elevated or is not depressed despite the hypercalcemia, findings that suggest hyperparathyroidism due to a genetic cause include syndromic manifestations in the patient or family members, parathyroid cancer (either suspected before surgery or confirmed during parathyroidectomy), multiple or recurrent parathyroid tumors, a family history of primary hyperparathyroidism, and the onset of primary hyperthyroidism before 50 years of age...
October 6, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Anna Wysoczańska-Klaczyńska, Aleksandra Ślęzak, Marta Hetman, Ewa Barg
Vitamin D activity is controlled by its receptor (VDR) located in many cells of the body. The presence of VDR in numerous cellular pathways suggests its important role in the etiology and development of many diseases. Increased risk of obesity, metabolic disturbances, bone mass disturbances and neoplasia among certain VDR alleles has been proven. The importance of VDR in the etiopathology of obesity is associated with the occurrence of polymorphisms: Fok1, Bsm1, Apa1, Taq1. VDR expression in adipocytes plays a role in the regulation of energy metabolism and the induction of obesity...
2018: Pediatric Endocrinology, Diabetes, and Metabolism
Christos Fountzilas, Milind Javle, Wei Tan, Yingyu Ma, Gerald Fetterly, Renuka Iyer, Candace Johnson
BACKGROUND: Calcitriol, the active analogue of vitamin D, is antiproliferative and enhances the cytotoxicity of several anticancer agents, including gemcitabine. The vitamin D receptor (VDR) is expressed in the tumor stroma and treatment with VDR ligands results in stromal remodeling and increased intratumoral gemcitabine delivery. Furthermore, calcitriol can decrease the activity of the gemcitabine deactivating enzyme cytidine deaminase (CDD). Because hypercalcemia has been the most worrisome calcitriol-related adverse event, the less hypercalcemic agent paricalcitol may be preferred for further investigation...
October 9, 2018: Cancer
Renata Kozyraki, Olivier Cases
Gp280/Intrinsic factor-vitamin B12 receptor/Cubilin (CUBN) is a large endocytic receptor serving multiple functions in vitamin B12 homeostasis, renal reabsorption of protein or toxic substances including albumin, vitamin D-binding protein or cadmium.Cubilin is a peripheral membrane protein consisting of 8 epidermal growth factor (EGF)-like repeats and 27 CUB (defined as Complement C1r/C1s, Uegf, BMP1) domains. This structurally unique protein interacts with at least two molecular partners, amnionless (AMN) and Lrp2/Megalin...
October 8, 2018: Current Medicinal Chemistry
Theodora Psaltopoulou, Ioannis Ntanasis-Stathopoulos, Diamantis I Tsilimigras, Ioannis-Georgios Tzanninis, Maria Gavriatopoulou, Theodoros N Sergentanis
There has been accumulating evidence that several micronutrients may play a protective role in the risk of solid cancers. However, their role in hematological malignancies remains to be elucidated; this meta-analysis aims to evaluate the associations between micronutrient intake as well as supplementation and risk of hematological cancer in adults. Eligible cohort studies (examining intake of vitamin A, vitamin C, vitamin D, vitamin E, lycopene, folate, iron, carotenoids, beta-carotene, selenium, pyridoxine) were sought in PubMed up to July 31, 2016...
October 5, 2018: Nutrition and Cancer
Hyuk Soo Eun, Sang Yeon Cho, Byung Seok Lee, In-Ock Seong, Kyung-Hee Kim
Cytochrome P450 family 4 (CYP4) enzymes are known as microsomal omega (ω)-hydroxylases that metabolize fatty acids, eicosanoids, vitamin D and carcinogens. Thus, CYP4 enzymes may influence tumor development and progression. The aim of the present study was to evaluate the CYP4 expression profile in hepatocellular carcinoma (HCC) and its clinical relevance. The present study obtained CYP4 mRNA expression data for 377 HCC cases from The Cancer Genome Atlas cohort and performed Kaplan‑Meier survival, Gene Ontology functional enrichment, and gene set enrichment analysis (GSEA)...
October 1, 2018: Molecular Medicine Reports
Liejun Jiang, Xiaomei Zhang, Yanyun Chen, Xiaocong Huo, Shuang Deng, Xiafang Yang, Yu Luo, Yanfang Luo, Xiaoxu Lu, Min Zhang, Huayi Huang
BACKGROUND: Acute leukemia is a common hematologic malignancy with poorly differentiated leukocytes. Alteration of circulating vitamin D (VD) and its carrier vitamin D binding protein (VDBP) have been reported in certain types of cancers and may play a role in the course of the disease. Understanding of the status of serum VD and VDBP, as well as the acute phase protein C-reactive protein (CRP) levels in pre- and post-treatment of acute leukemia patients, may be helpful in the management of acute leukemia...
September 1, 2018: Clinical Laboratory
Elizabeth A Isenring, Laisa Teleni, Richard J Woodman, Michael G Kimlin, Euan Walpole, Christos S Karapetis, Shawgi Shawgi, Ganessan Kichenadasse, Skye Marshall, Bogda Koczwara
BACKGROUND AND OBJECTIVES: Vitamin D plays an important role in bone and muscle function, and cell prolifera-tion. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vit-amin D (25(OH) D) is unknown. This study aims to evaluate variations in serum vitamin D during chemotherapy and the predictive value of latitude, season and pre-existing vitamin D deficiency. METHODS AND STUDY DESIGN: A 12-week prospective cohort study was conducted in chemotherapy-naïve patients in two Australian locations with different sun exposure...
2018: Asia Pacific Journal of Clinical Nutrition
Natascha Roehlen, Claudia Doering, Martin-Leo Hansmann, Frank Gruenwald, Christian Vorlaender, Wolf Otto Bechstein, Katharina Holzer, Klaus Badenhoop, Marissa Penna-Martinez
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects...
2018: Frontiers in Endocrinology
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