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Vitamin D Cancer

Muhammad Abdullah Zain, Abbas Raza, Muhammad Owais Hanif, Zehra Tauqir, Maryam Khan, Muhammad J Mahboob, Fariha Ashraf, Waqas Javed Siddiqui, Hasan Arif, Larry E Krevolin
BACKGROUND Patients with malignancies often have electrolyte abnormalities. We present a case of a patient with central diabetes insipidus secondary to metastatic pituitary invasion complicated by hypercalcemic nephrogenic diabetes insipidus. CASE REPORT We present a case of 40-year-old female with a history of stage IV breast cancer with skeletal and leptomeningeal metastasis, who was admitted with polyuria, polydipsia, and recent onset of confusion. The patient was found to have profound hypernatremia and severe hypercalcemia with normal parathyroid and vitamin D serum levels...
August 18, 2018: American Journal of Case Reports
Abdulbari Bener, Yasar Ozdenkaya, Abdulla O A A Al-Hamaq, Cem Cahit Barisik, Mustafa Ozturk
Background: The aim of this study was to investigate the relationship between vitamin D deficiency and thyroid diseases among type 2 diabetes mellitus (T2DM) patients. Methods: This was a cohort case and control study, 546 T2DM patients and 546 control study participants were enrolled, aged between 25 and 65 years. The subjects were also investigated for fasting blood glucose levels (FBG), post prandial glucose (PPG,) glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH), T3, T4, and presence of other comorbid conditions...
September 2018: Journal of Clinical Medicine Research
C A Buckner, R M Lafrenie, J A Dénommée, J M Caswell, D A Want
Background: Cancer patients are increasingly seeking out complementary and alternative medicine (cam) and might be reluctant to disclose its use to their oncology treatment team. Often, cam agents are not well studied, and little is known about their potential interactions with chemotherapy, radiation therapy, or biologic therapies, and their correlations with outcomes. In the present study, we set out to determine the rate of cam use in patients receiving treatment at a Northern Ontario cancer centre...
August 2018: Current Oncology
Tracy M Layne, Barry I Graubard, Xiaomei Ma, Susan T Mayne, Demetrius Albanes
BACKGROUND: There are few prospective studies comparing race-specific associations between diet, nutrients, and health-related parameters, and prostate cancer risk. METHODS: Race-specific prostate cancer risk associations were examined among men in the National Institutes of Health (NIH)-AARP Diet and Health Study. We identified 1417 cases among black men (209 advanced), and 28,845 among white men (3898 advanced). Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs)...
August 14, 2018: Prostate Cancer and Prostatic Diseases
Federico Innocenti, Kouros Owzar, Chen Jiang, Amy S Etheridge, Raluca Gordân, Alexander B Sibley, Flora Mulkey, Donna Niedzwiecki, Dylan Glubb, Nicole Neel, Mark S Talamonti, David J Bentrem, Eric Seiser, Jen Jen Yeh, Katherine Van Loon, Howard McLeod, Mark J Ratain, Hedy L Kindler, Alan P Venook, Yusuke Nakamura, Michiaki Kubo, Gloria M Petersen, William R Bamlet, Robert R McWilliams
PURPOSE: Advanced pancreatic cancer is a highly refractory disease almost always associated with survival of little more than a year. New interventions based on novel targets are needed. We aim to identify new genetic determinants of overall survival (OS) in patients after treatment with gemcitabine using genome-wide screens of germline DNA. We aim also to support these findings with in vitro functional analysis. PATIENTS AND METHODS: Genome-wide screens of germline DNA in two independent cohorts of pancreatic cancer patients (from the Cancer and Leukemia Group B (CALGB) 80303 and the Mayo Clinic) were used to select new genes associated with OS...
2018: PloS One
Yazhou He, Maria Timofeeva, Susan M Farrington, Peter Vaughan-Shaw, Victoria Svinti, Marion Walker, Lina Zgaga, Xiangrui Meng, Xue Li, Athina Spiliopoulou, Xia Jiang, Elina Hyppönen, Peter Kraft, Douglas P Kiel, Caroline Hayward, Archie Campbell, David Porteous, Katarina Vucic, Iva Kirac, Masa Filipovic, Sarah E Harris, Ian J Deary, Richard Houlston, Ian P Tomlinson, Harry Campbell, Evropi Theodoratou, Malcolm G Dunlop
BACKGROUND: Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since vitamin D is modifiable, these observations have substantial clinical and public health implications. Indeed, many health agencies already recommend supplemental vitamin D. Here, we explore causality in a large Mendelian randomisation (MR) study using an improved genetic instrument for circulating 25-OHD...
August 14, 2018: BMC Medicine
Robyn M Lucas, Rachael M Rodney Harris
If environmental exposures are shown to cause an adverse health outcome, reducing exposure should reduce the disease risk. Links between exposures and outcomes are typically based on 'associations' derived from observational studies, and causality may not be clear. Randomized controlled trials to 'prove' causality are often not feasible or ethical. Here the history of evidence that tobacco smoking causes lung cancer-from observational studies-is compared to that of low sun exposure and/or low vitamin D status as causal risk factors for the autoimmune disease, multiple sclerosis (MS)...
August 12, 2018: International Journal of Environmental Research and Public Health
Lichchavi D Rajasinghe, Rohini H Pindiprolu, Smiti Vaid Gupta
Background: Delta-tocotrienol (δT), an isomer of vitamin E, exhibits anticancer properties in different cancer types including non-small-cell lung cancer (NSCLC). Yet, anti-invasive effects of δT and its underlying cellular mechanism in NSCLC have not been fully explored. Matrix metalloproteinase 9 (MMP-9)-based cell migration and invasion are critical cellular mechanisms in cancer development. The current evidence indicates that MMP-9 is upregulated in most patients, and the inhibition of MMPs is involved in decreasing invasion and metastasis in NSCLC...
2018: OncoTargets and Therapy
Emily W Gilbert, Chau T Tay, Danielle S Hiam, Helena Teede, Lisa J Moran
BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting reproductive-aged women with adverse reproductive, metabolic and psychological outcomes. It has a complex pathophysiology and therefore requires a multi-discipline clinical approach. However, there remains limited research synthesizing the broad clinical implications of PCOS which would assist clinicians in the management of PCOS. OBJECTIVE: To summarise and appraise methodological quality of systematic reviews and meta-analyses evaluating complications and comorbidities associated with PCOS...
August 12, 2018: Clinical Endocrinology
Greta Chiara Cermisoni, Alessandra Alteri, Laura Corti, Elisa Rabellotti, Enrico Papaleo, Paola Viganò, Ana Maria Sanchez
Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing the mechanisms underlying VD action in the physiologic endometrium and in endometrial pathologies are still scant. Levels of VDR expression according to the menstrual cycle are yet to be definitively clarified, possibly being lower in the proliferative compared to the secretory phase and in mid-secretory compared to early secretory phase...
August 8, 2018: International Journal of Molecular Sciences
Cristian Ruiz-Moreno, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
Neuroblastoma (NB) is the most common neoplasm during infancy. Unfortunately, NB is still a lethal cancer. Therefore, innovative curative therapies are immediately required. In this study, we showed the pro-death activity of TPGS in human NB SK-N-SH cancer cells. NB cells were exposed to TPGS (10-80 μM). We report for the first time that TPGS induces cell death by apoptosis in NB cells via a pro-oxidant-mediated signaling pathway. Certainly, H2O2 directly oxidizes DJ-1 cysteine106-thiolate into DJ-1 cysteine106-sulfonate; indirectly activates the transcription factors NF-kappaB, P53 and c-JUN; induces up-regulation of mitochondria regulator proteins BAX/PUMA; provokes loss of mitochondrial membrane potential (m) and activation of CASPASE-3/AIF, leading to nuclear disintegration, demonstrated by cellular and biochemical techniques such as fluorescence microscopy, flow cytometry and Western blot analysis...
August 9, 2018: Chemical Research in Toxicology
Lorenzo Mortara, Marzia B Gariboldi, Annalisa Bosi, Marco Bregni, Graziella Pinotti, Luigina Guasti, Alessandro Squizzato, Douglas M Noonan, Elena Monti, Leonardo Campiotti
BACKGROUND: Hypovitaminosis D is associated with an adverse prognosis in colon cancer patients, possibly due to the effects of the vitamin on the immune system. Antibody-dependent cell-mediated cytotoxicity (ADCC) significantly contributes to the anti-tumor effects of monoclonal antibodies, including cetuximab, an epidermal growth factor receptor (EGFR)-targeted monoclonal antibody that is frequently added to chemotherapy in the treatment of colon cancer. OBJECTIVE: The present study evaluates the association between vitamin D serum levels and the ability of ex vivo NK cells to support cetuximab-mediated ADCC in colon cancer cell lines...
August 9, 2018: Targeted Oncology
P Aparna, S Muthathal, Baridalyne Nongkynrih, Sanjeev Kumar Gupta
Vitamin D is a fat-soluble vitamin playing a vital role in human physiology. Vitamin D deficiency is prevalent worldwide. This deficiency has many consequences which are still being explored, apart from the well-known skeletal complications. With this review, we aim to summarize the existing literature on Vitamin D status in India and understand the enormity of the problem. The prevalence of Vitamin D deficiency ranged from 40% to 99%, with most of the studies reporting a prevalence of 80%-90%. It was prevalent in all the age groups and high-risk groups alike...
March 2018: Journal of Family Medicine and Primary Care
Naveen R Parva, Satish Tadepalli, Pratiksha Singh, Andrew Qian, Rajat Joshi, Hyndavi Kandala, Vinod K Nookala, Pramil Cheriyath
Introduction 1,25-dihydroxyvitamin D3 (cholecalciferol), the hormonally active form of vitamin D3, is a lipid-soluble compound that plays a significant role in clinical medicine due to its potent effects on calcium homeostasis and bone metabolism. Since foods containing natural vitamin D are rare, the primary source of the compound remains its nonenzymatic dermal synthesis through exposure to ultraviolet rays in sunlight. Although uncommon in most developed countries, recent literature has demonstrated that subclinical vitamin D deficiency can exist in certain populations and plays a role in downstream clinical consequences, including cardiovascular disease, cancer, diabetes, osteoporosis, and fractures...
June 5, 2018: Curēus
Junyu Zhao, Haipeng Wang, Zhongwen Zhang, Xiaojun Zhou, Jinming Yao, Rui Zhang, Lin Liao, Jianjun Dong
OBJECTIVE: The association between vitamin D deficiency and thyroid cancer is controversial. Some studies have demonstrated that higher serum vitamin D levels might protect against thyroid cancer, whereas others have not, or have even indicated the opposite to be the case. The aim of this meta-analysis was to investigate the association between vitamin D deficicency and thyroid cancer and propose that vitamin D deficiency is a risk factor for thyroid cancer. METHODS: This was a meta-analysis of 14 articles of the association between vitamin D deficiency and thyroid cancer...
June 2, 2018: Nutrition
Burak Toprak, Ayfer Colak, Hulya Yalcin, Mustafa Yildirim
BACKGROUND AND AIM: Vitamin D deficiency and oxidative stress were suggested to be related to prostate cancer risk. We aimed to investigate the association of serum PSA concentration with vitamin D and total oxidant/antioxidant levels. MATERIALS AND METHODS: A total of 95 healthy men were enrolled for the cross sectional study. Serum PSA, 25(OH)D, serum total oxidant status, and total antioxidant status were measured. RESULTS: Serum PSA was significantly negatively correlated with serum total oxidant status (r= -0...
August 7, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Stephanie J Weinstein, Alison M Mondul, Kai Yu, Tracy M Layne, Christian C Abnet, Neal D Freedman, Racheal Z Stolzenberg-Solomon, Unhee Lim, Mitchell H Gail, Demetrius Albanes
While vitamin D has been associated with improved overall cancer survival in some investigations, few have prospectively evaluated organ-specific survival. We examined the accepted biomarker of vitamin D status, serum 25-hydroxyvitamin D [25(OH)D], and cancer survival in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Of 4616 cancer cases with measured serum 25(OH)D, 2884 died of their cancer during 28 years of follow-up and 1732 survived or died of other causes. Proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for the association between pre-diagnostic 25(OH)D and overall and site-specific survival...
August 2, 2018: European Journal of Epidemiology
Vanessa Y Tan, Kalina M Biernacka, Tom Dudding, Carolina Bonilla, Rebecca Gilbert, Robert C Kaplan, Qibin Qi, Alexander Teumer, Richard M Martin, Claire M Perks, Nicholas J Timpson, Jeff Mp Holly
BACKGROUND: Circulating insulin-like growth factor binding protein 3 (IGFBP-3) has been associated with PCa. Preclinical studies found that vitamin D regulates IGFBP-3 expression, although evidence from epidemiological studies are conflicting. METHODS: Mendelian Randomisation analyses (MR) were conducted to reassess associations between IGFBP-3 and Prostate cancer (PCa) risk and advanced PCa using summary statistics from the PRACTICAL consortium (44,825cases;27,904controls)...
August 2, 2018: Cancer Epidemiology, Biomarkers & Prevention
Aslı Aksu Çerman, Ezgi Aktaş Karabay, Ilknur Kivanc Altunay, Seher Küçükoğlu Cesur
BACKGROUND: Recent studies that investigated the effect of vitamin D on skin cancer risk have exhibited inconsistent results. OBJECTIVE: The aim of the study was to evaluate vitamin D status in patients with actinic keratosis. METHODS: A cross-sectional study was conducted on 31 patients with actinic keratosis and 29 healthy controls. Serum vitamin D levels in the study group were determined by liquid chromatography/tandem mass spectrometry...
July 2018: Anais Brasileiros de Dermatologia
Stefan Pilz, Winfried März, Kevin D Cashman, Mairead E Kiely, Susan J Whiting, Michael F Holick, William B Grant, Pawel Pludowski, Mickael Hiligsmann, Christian Trummer, Verena Schwetz, Elisabeth Lerchbaum, Marlene Pandis, Andreas Tomaschitz, Martin R Grübler, Martin Gaksch, Nicolas Verheyen, Bruce W Hollis, Lars Rejnmark, Spyridon N Karras, Andreas Hahn, Heike A Bischoff-Ferrari, Jörg Reichrath, Rolf Jorde, Ibrahim Elmadfa, Reinhold Vieth, Robert Scragg, Mona S Calvo, Natasja M van Schoor, Roger Bouillon, Paul Lips, Suvi T Itkonen, Adrian R Martineau, Christel Lamberg-Allardt, Armin Zittermann
Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas intake by nutrition traditionally plays a relatively minor role. Dietary guidelines for vitamin D are based on a consensus that serum 25-hydroxyvitamin D (25[OH]D) concentrations are used to assess vitamin D status, with the recommended target concentrations ranging from ≥25 to ≥50 nmol/L (≥10-≥20 ng/mL), corresponding to a daily vitamin D intake of 10 to 20 μg (400-800 international units)...
2018: Frontiers in Endocrinology
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