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https://www.readbyqxmd.com/read/28728424/annals-express-false-negative-results-in-the-immunoassay-analysis-of-drugs-of-abuse-can-adulterants-be-detected-by-sample-check-test
#1
Barbara Matriciani, Bernd Huppertz, Ruprecht Keller, Ralf Weiskirchen
BACKGROUND: The dilution or adulteration of urine is a serious problem in drugs of abuse (DOA) testing. Tests to identify adulteration are currently available. This study investigated the ability of the CEDIA® sample check to detect adulteration. METHODS: Eight different DOAs were added to a urine sample obtained from a healthy, drug free subject: 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, 3,4-methylenedioxyamphetamine, benzoylecgonine, D-amphetaminesulfate, ethyl-D-glucuronide, morphine sulfate, oxazepam, (-)-11-nor-9-carboxy-∆(9)-tetrahydrocannabinol...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28726485/annals-express-20%C3%AE-and-20%C3%AE-dihydrocortisone-may-interfere-in-lc-ms-ms-determination-of-cortisol-in-saliva-and-urine
#2
Marlen Israelsson, Ralph Brattsand, Goran Brattsand
BACKGROUND: LC-MS/MS methods offer high selectivity in cortisol determinations. However, endogenous steroid metabolites may still interfere and compromise the results, for example in the diagnosis of Cushing´s syndrome. Erroneously elevated cortisol may, in particular, be misleading at the low concentrations found in salivary samples obtained at late night and after dexamethasone suppression. METHODS: Interferences in our LC-MS/MS method used for determination of cortisol in saliva and urine were identified by comparing their retention times and mass spectra with those of pure candidate substances...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28726484/annals-express-experience-with-newer-central-nervous-system-autoantibodies
#3
Abid Karim, Saiju Jacob
In the last decade, a large number of neuronal cell-surface antibodies have been described which are responsible for a range of neuroimmunological central nervous system disorders. Unlike the paraneoplastic antibodies which target intracellular antigens, these antibodies appear to be pathogenic and hence identification and prompt treatment can make a substantial impact on clinical outcomes of these patients. We review the common antibodies against the ionotropic Glutamate receptors (NMDAR, AMPAR), metabotropic Glutamate receptors (mGluR1 and mGluR5), voltage gated potassium channel-complex proteins (LGI1, CASPR2), and other antibodies targeted against Glycine receptor, Glutamic acid decarboxylase (GAD), Gamma Amino Butyric Acid B (GABAB), Dopamine-2-receptor (D2R) and Dipeptidyl-peptidase-like protein 6 (DPPX)...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28720618/interpretation-of-cis-in-clinical-trials-with-non-significant-results-systematic-review-and-recommendations
#4
Jennifer S Gewandter, Michael P McDermott, Rachel A Kitt, Jenna Chaudari, James G Koch, Scott R Evans, Robert A Gross, John D Markman, Dennis C Turk, Robert H Dworkin
OBJECTIVES: Interpretation of CIs in randomised clinical trials (RCTs) with treatment effects that are not statistically significant can distinguish between results that are 'negative' (the data are not consistent with a clinically meaningful treatment effect) or 'inconclusive' (the data remain consistent with the possibility of a clinically meaningful treatment effect). This interpretation is important to ensure that potentially beneficial treatments are not prematurely abandoned in future research or clinical practice based on invalid conclusions...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28718304/the-role-of-surgery-in-low-grade-gliomas-do-timing-and-extent-of-resection-matter
#5
Hugues Duffau
Hugues Duffau is a Professor and Chairman of the Neurosurgery Department in the Montpellier University Medical Center and Head of the INSERM 1051 Team "plasticity of the central nervous system, human stem cells and glial tumors" at the Institute for Neurosciences of Montpellier (France). He is an expert in the awake cognitive neurosurgery of slow-growing brain tumors, such as low-grade gliomas, a routine which he has developed since 20 years. His fundamental approach is centered on the concepts of the brain connectomics and neuroplasticity, breaking with the traditional localizationist view of cerebral processing...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28715841/annals-for-educators-18-july-2017
#6
Darren B Taichman
No abstract text is available yet for this article.
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28715840/annals-consult-guys-let-me-out-of-here-how-long-to-remain-hospitalized-after-an-mi
#7
Geno J Merli, Howard H Weitz
No abstract text is available yet for this article.
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28715839/annals-for-hospitalists-inpatient-notes-the-opioid-epidemic-what-s-a-hospitalist-to-do
#8
Pooja Lagisetty, Amy Bohnert
No abstract text is available yet for this article.
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28715838/annals-for-hospitalists-celebrating-the-one-year-anniversary-of-an-easier-way-for-hospitalists-to-access-annals
#9
David H Wesorick, Vineet Chopra
No abstract text is available yet for this article.
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28715834/annals-for-hospitalists-18-july-2017
#10
David H Wesorick, Vineet Chopra
No abstract text is available yet for this article.
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28700358/antihyperglycemic-treatment-in-patients-with-type-2-diabetes-in-italy-the-impact-of-age-and-kidney-function
#11
Sandro Gentile, Pamela Piscitelli, Francesca Viazzi, Giuseppina Russo, Antonio Ceriello, Carlo Giorda, Piero Guida, Paola Fioretto, Roberto Pontremoli, Felice Strollo, Salvatore De Cosmo, The Amd-Annals Study Group
We describe AHA utilization pattern according to age and renal function in type 2 diabetes mellitus (T2DM), in real-life conditions.The analysis was performed using the data set of electronic medical records collected between 1 January and 31 December, 2011 in 207 Italian diabetes centers. The study population consisted of 157,595 individuals with T2DM. The AHA treatment regimens was evaluated. Kidney function was assessed by eGFR, estimated using the CKD-EPI formula. Other determinations: HbA1c, blood pressure (BP), low- density lipoprotein (LDL-c), total and high density lipoprotein cholesterol (TC and HDL-c), triglycerides (TG) and serum uric acid (SUA)...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28690984/the-rapid-internationalization-of-annals-of-pediatric-endocrinology-metabolism-as-evidenced-by-journal-metrics
#12
Sun Huh
PURPOSE: Using journal metrics, this paper explores whether Annals of Pediatric Endocrinology & Metabolism has internationalized 4 years after changing its language to English only. METHODS: From the journal's website and the Web of Science Core Collection, the following metrics were counted or calculated: Number of citable articles, countries of authors and editorial board members, total citations, impact factor, countries of citing authors, citing journal titles, and Hirsch index...
June 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28672403/annals-for-the-ages-annals-of-internal-medicine-turns-90
#13
George D Lundberg
No abstract text is available yet for this article.
July 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28672394/annals-for-educators-4-july-2017
#14
Darren B Taichman
No abstract text is available yet for this article.
July 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28672381/annals-graphic-medicine-july-plunge
#15
Michael Natter
No abstract text is available yet for this article.
July 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28672380/annals-graphic-medicine-internship
#16
Jason Bitterman
No abstract text is available yet for this article.
July 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28667044/annals-of-clinical-and-laboratory-science-information-for-authors
#17
(no author information available yet)
No abstract text is available yet for this article.
May 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28656819/annals-express-urinary-albumin-a-risk-marker-under-requested-in-primary-care-in-spain
#18
Maria Salinas, Maite Lopez-Garrigos, Emilio Flores, Carlos Leiva-Salinas
BACKGROUND: To study the inter-practice regional variation in the request of urinary albumin (MAU) by general practitioners (GPs) and compare to guideline recommendations. METHODS: A cross-sectional study enrolled laboratories from different Spanish Autonomous Communities (AACCs). Laboratories were invited to report the number of MAU requested by GPs during 2012 and 2014. MAU requested per 1000 inhabitants and the index of variability (90(t)(h) centile / 10(t)(h) centile)/Percentile10) were calculated, and compared between AACCs and time periods...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28656817/annals-express-high-sensitivity-troponin-t-and-i-reflect-left-atrial-function-being-assessed-by-cardiac-magnetic-resonance-imaging-cmri
#19
Michele Natale, Michael Behnes, Seung-Hyun Kim, Julia Hoffmann, Nadine Reckord, Ursula Hoffmann, Johannes Budjan, Siegfried Lang, Martin Borggrefe, Theano Papavassiliu, Thomas Bertsch, Ibrahim Akin
BACKGROUND: Left atrial function (LAF) plays an interactive role between pulmonary and systemic circulation. Cardiac biomarkers, such as amino-terminal pro-brain natriuretic peptide (NT-proBNP) and troponins, might reflect cardiac function. This study aims to evaluate the association between high sensitivity troponins (hsTn) and LAF in patients undergoing cMRI. METHODS: Patients undergoing cMRI were enrolled prospectively. Patients with right ventricular dysfunction (< 50%) were excluded...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28656816/annals-express-quantitative-measurement-of-a-candidate-serum-biomarker-peptide-derived-from-%C3%AE-2-hs-glycoprotein-and-a-preliminary-trial-of-multi-dimensional-peptide-analysis-in-females-with-pregnancy-induced-hypertension
#20
Kensuke Hamamura, Mitsuaki Yanagida, Hitoshi Ishikawa, Michio Banzai, Hiroshi Yoshitake, Daisuke Nonaka, Kenji Tanaka, Mayumi Sakuraba, Yasuka Miyakuni, Kenji Takamori, Michio Nojima, Koyo Yoshida, Hiroshi Fujiwara, Satoru Takeda, Yoshihiko Araki
PURPOSE: We previously attempted to develop quantitative enzyme-linked immunosorbent assay (ELISA) systems for the PDA039/044/071 peptides, potential serum disease biomarkers (DBMs) of pregnancy-induced hypertension (PIH), primarily identified by a peptidomic approach (BLOTCHIP(®)-mass spectrometry (MS)). However, our methodology did not extend to PDA071 (cysteinyl α2-HS-glycoprotein341-367), due to difficulty to produce a specific antibody against the peptide. The aim of the present study was to establish an alternative PDA071 quantitation system using liquid chromatography-multiple reaction monitoring (LC-MRM )/MS, to explore the potential utility of PDA071 as a DBM for PIH...
January 1, 2017: Annals of Clinical Biochemistry
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