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Salvatore De Cosmo, Francesca Viazzi, Antonio Pacilli, Carlo Giorda, Antonio Ceriello, Sandro Gentile, Giuseppina Russo, Maria C Rossi, Antonio Nicolucci, Pietro Guida, Roberto Pontremoli
: The identification of clinical predictors for the development of chronic kidney disease is a critical issue in the management of patients with type 2 diabetes mellitus.We evaluated 27,029 patients with type 2 diabetes mellitus and estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m and normoalbuminuria from the database of the Italian Association of Clinical Diabetologists network. Primary outcomes were eGFR <60 mL/min/1.73 m and normoalbuminuria; albuminuria and eGFR ≥60 mL/min/1...
July 2016: Medicine (Baltimore)
David H Wesorick, Vineet Chopra
No abstract text is available yet for this article.
October 18, 2016: Annals of Internal Medicine
Hardeep Singh, Laura Zwaan
No abstract text is available yet for this article.
October 18, 2016: Annals of Internal Medicine
Darren B Taichman
No abstract text is available yet for this article.
October 18, 2016: Annals of Internal Medicine
V Morelli, A Scillitani, M Arosio, I Chiodini
Recently, the European Society of Endocrinology (ESE) published new guidelines on the management of adrenal incidentalomas. At the same time Lopez and coworkers published on the Annals of Internal Medicine an important study showing that even patients with non-functioning adrenal tumors have an increased risk of incident diabetes. In consideration of previous data and of the results of the study of Lopez and coworkers, some points emerge from the ESE Guidelines that deserve attention. Firstly, it must be observed that the term "autonomous cortisol secretion," introduced by the ESE Panel in the place of the commonly used "subclinical hypercortisolism," seems questionable, since the guidelines do not suggest determining the adrenocorticotroph hormone levels that could give the certain proof of a truly autonomous cortisol secretion...
October 15, 2016: Journal of Endocrinological Investigation
Andrew Duncan, Calum Yacoubian, Robert Beetham, Anthony Catchpole, David Bullock
BACKGROUND: US and European guidelines suggest the use of calculated non-caeruloplasmin bound copper (free copper index) for the diagnosis and management of Wilson's Disease. However, there is concern that the required analytical measurements of caeruloplasmin and copper may not be sufficiently robust at the concentrations usually found. METHODS: Aliquots of six plasma specimens were sent to laboratories participating in the UK National External Quality Assessment Scheme for copper and caeruloplasmin...
October 13, 2016: Annals of Clinical Biochemistry
Emmanuel Richard, Jean-Marc Blouin, Jerome Harambat, Brigitte Llanas, Stephane Bouchet, Cecile Acquaviva, Renaud De la Faille
We report the case of a 78-year-old patient with late diagnosis of hyperoxaluria type III (PH3). He developed renal failure after nephrectomy for clear cell papillary renal carcinoma and complained of recurrent urolithiasis for some 30 years whose etiology was never identified. Biochemical laboratory investigations of urine and urolithiasis composition revealed marked hyperoxaluria but normal levels of urinary glyceric and glycolic acid as well as stones of idiopathic calcium-oxalate appearance. Furthermore, the dietary survey showed excessive consumption of food supplements containing massive amounts of oxalate precursors...
October 13, 2016: Annals of Clinical Biochemistry
Seyyed Mohammad Reza Kazemi-Bajestani, Maryam Tayefi, Mahmoud Ebrahimi, Ali Reza Heidari-Bakavoli, Mohsen Moohebati, Seyyed Mohammad Reza Parizade, Habib-Allah Esmaeili, Gordon Ferns, Majid Ghayour-Mobarhan
BACKGROUND: Metabolic syndrome (MetS) is defined by a clustering of cardiovascular (CV) risk factors and is associated with a heightened inflammatory state. A raised serum high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation, is also known to associate with CV risk. We have investigated the relationship between the presence of MetS and serum hs-CRP concentration in a large representative Persian population cohort without a history of cardiovascular disease (CVD). METHODS: The MASHAD study population cohort comprised 9 778 subjects, who were recruited from the city of Mashhad, Iran, between 2007 and 2008...
October 13, 2016: Annals of Clinical Biochemistry
Richard X Davey
BACKGROUND: The misnamed 'vitamin' D is actually the hormone calcitriol (1,25 dihydroxyhydroxyvitamin D). It has a central regulatory role in calcium metabolism, and more widely in the immune system. The prohormone calcifediol (25 hydroxyvitamin D) is more easily measured in the laboratory and is the analyte used in reference interval formulation. Being highly lipid soluble, both calcifediol and calcitriol travel in the bloodstream on carriage proteins, principally on vitamin D binding protein, DBP...
October 13, 2016: Annals of Clinical Biochemistry
Romain Rivoirard, Vianney Duplay, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Nicolas Magne, Aurelie Bourmaud
BACKGROUND: Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. METHODS: From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC)...
2016: PloS One
Elif Azarsız, Neslihan Karaca, Erturk Levent, Necil Kutukculer, Eser Sozmen
BACKGROUND: Common variable immunodeficiency (CVID) is a rare clinically symptomatic primary immunodeficiency disorder which manifests a wide variability of symptoms, complications. Atherosclerosis in CVID patients have not been investigated yet contrary to other severe clinical complications. We aimed to investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker in pediatric CVID patients. METHODS: CVID patients (n =24) and healthy controls (n = 23) evaluated for chitotriosidase activity with other inflammation markers (hsCRP, myeloperoxidase, serum amyloid A, ferritin), lipid profile and echocardiographic findings (carotid artery intima media thickness - cIMT, brachial artery flow-mediated vazodilatation - FMD%)...
October 4, 2016: Annals of Clinical Biochemistry
Masafumi Koga, Rie Matsumoto
BACKGROUNDS: The effect of alcohol consumption on glycemic control indicators is not well known. In this study, we studied the effect of alcohol consumption on the plasma glucose and glycemic control indicators in non-diabetic men. METHODS: The study enrolled 300 non-diabetic men who received a complete medical checkup [age: 52.8 ± 6.5 years, body mass index (BMI): 24.4 ± 2.8 kg/m(2)]. The subjects were divided into four groups by the amount of alcohol consumed, and the plasma glucose, HbA1c, glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG) levels of the groups were compared...
October 4, 2016: Annals of Clinical Biochemistry
Jaimini Cegla, Ben Jones, James Howard, Richard Kay, Colin S Creaser, Stephen R Bloom, Tricia Tan
BACKGROUND: One of the main challenges in the measurement of glucagon is the premise that it is unstable in human plasma. Traditionally, protease inhibitors have been used to prevent its degradation, however, their use is controversial. Here we investigated the optimal method of sample collection for glucagon, with measurement by liquid chromatography tandem mass spectrometry (LC-MS/MS) and two commercially available immunoassays. METHODS: Blood from healthy fasting volunteers (n=10) was processed under a variety of pre-analytical condition including collection in EDTA vs lithium heparin tubes and the addition of aprotinin and/or a DPPIV inhibitor...
October 4, 2016: Annals of Clinical Biochemistry
Giuseppina T Russo, Salvatore De Cosmo, Francesca Viazzi, Antonio Pacilli, Antonio Ceriello, Stefano Genovese, Pietro Guida, Carlo Giorda, Domenico Cucinotta, Roberto Pontremoli, Paola Fioretto
OBJECTIVE: Despite the achievement of blood glucose, blood pressure, and LDL-cholesterol (LDL-C) targets, the risk for diabetic kidney disease (DKD) remains high among patients with type 2 diabetes. This observational retrospective study investigated whether diabetic dyslipidemia-that is, high triglyceride (TG) and/or low HDL-cholesterol (HDL-C) levels-contributes to this high residual risk for DKD. RESEARCH DESIGN AND METHODS: Among a total of 47,177 patients attending Italian diabetes centers, 15,362 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1...
October 4, 2016: Diabetes Care
Yingying Peng, James Uprichard Uprichard
Anaemia is a condition in which the number of red cells necessary to meet the body's physiological requirements is insufficient. Iron deficiency anaemia (IDA) and the anaemia of chronic disease (ACD) are the two most common causes of anaemia worldwide; iron homeostasis plays a pivotal role in the pathogenesis of both diseases. An understanding of how iron studies can be used to distinguish between these diseases is therefore essential, not only for diagnosis but also in guiding management. This review will primarily focus on IDA and ACD; however iron overload in anaemia will also be briefly discussed...
October 3, 2016: Annals of Clinical Biochemistry
Darren B Taichman
No abstract text is available yet for this article.
October 4, 2016: Annals of Internal Medicine
Kartik A Valluri
No abstract text is available yet for this article.
October 4, 2016: Annals of Internal Medicine
Robert M McCarron, Erik R Vanderlip, Jeffrey Rado
This issue provides a clinical overview of depression, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
October 4, 2016: Annals of Internal Medicine
Valeria Manicardi, Giuseppina Russo, Angela Napoli, Elisabetta Torlone, Patrizia Li Volsi, Carlo Bruno Giorda, Nicoletta Musacchio, Antonio Nicolucci, Concetta Suraci, Giuseppe Lucisano, Maria Chiara Rossi
We evaluated gender-differences in quality of type 1 diabetes (T1DM) care. Starting from electronic medical records of 300 centers, 5 process indicators, 3 favorable and 6 unfavorable intermediate outcomes, 6 treatment intensity/appropriateness measures and an overall quality score were measured. The likelihood of women vs. men (reference class) to be monitored, to reach outcomes, or to be treated has been investigated through multilevel logistic regression analyses; results are expressed as Odd Ratios (ORs) and 95% confidence intervals (95%CIs)...
2016: PloS One
Arun Sankaralingam, Annette Thomas, David James, Anthony S Wierzbicki
BACKGROUND: Ethylene glycol (EG) poisoning remains a rare but important presentation to acute toxicology units. Guidelines recommended that Ethylene Glycol should be available as an 'urgent' test within 4 hours but these are difficult to deliver in practice. This study assessed a semi-quantitative enzymatic spectrophotometric assay for EG compatible with automated platforms. METHODS: The EG method was assessed in 21 samples from patients with an increased anion gap and metabolic acidosis not due to EG ingestion, and 7 samples known to contain EG...
September 28, 2016: Annals of Clinical Biochemistry
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